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- Xandra O. Breakefield, Ph.D.Exit Disclaimer
- Title: Professor, Neurology, Harvard Medical School; Geneticist in Radiology at Massachusetts General Hospital
- Institution: Massachusetts General HospitalExit Disclaimer
- Research: Glioblastoma releases extracellular vesicles containing nucleic acids and proteins that convert normal brain cells to tumor supportive cells. Breakefield will explore how tumor extracellular vesicles participate in changing the phenotype of microglia, macrophages and astrocytes in the tumor microenvirons and analyze the microenvironment which sustains the tumor. This research is designed to increase sensitivity and reveal clinical correlates of RNA and protein in extracellular vesicle biomarkers from serum/plasma with the goals of early detection, informing therapeutic decisions and longitudinal evaluation.
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