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- Title: Member, Basic Sciences Division
- Institution: Fred Hutchinson Cancer Research Center
- Research: Research in the Eisenman lab is focused on the MYC transcription factor network, whose interacting components comprise a broadly acting gene regulatory system. The MYC network is essential for normal cellular functions but, when dysregulated, drives formation of multiple tumor types. Work in the lab is directed towards three areas: role of the MLXIP protein in alleviating cellular stress upon MYC-induced metabolic reprograming in cancer; mechanism of tumor suppression by Mga, another member of the MYC network; and point mutations within MYC that activate its oncogenic functions.
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