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- Channing J. Der, Ph.D.Exit Disclaimer
- Title: Sarah Graham Kenan Distinguished Professor of Pharmacology
- Institution: University of North Carolina at Chapel Hill
- Research: Der focuses on pancreatic ductal adenocarcinoma (PDAC), a cancer where effective therapies remain to be found. His research will focus on exploiting novel protein kinases that regulate MYC protein stability to cause MYC loss, determining key ERK substrates that are critical for ERK-dependent KRAS-mutant PDAC growth, applying experimental approaches to define YAP1–independent mechanisms, and pursuing outlier mutations in PDAC to identify mutation-specific vulnerabilities as the basis for the development of mutation-selective therapies. These findings will help develop anti-KRAS therapies and achieve breakthroughs needed for development of anti-RAS oncogene therapies that can impair growth of PDAC.
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