Translations:Research/key-initiatives/ras/spokes-funding/11/en

Peter Jackson, Michael C. Bassik, and Alejandro Sweet-Cordero, Stanford University School of Medicine

Peter Jackson, Michael C. Bassik, and Alejandro Sweet-Cordero, Stanford University School of Medicine, for "Using Protein Interaction Networks and Combinatorial Screens to Target KRAS-driven Cancer." Drs. Jackson, Bassik, and Sweet-Cordero and their team will look for synthetic lethalities in non-small cell lung cancers expressing mutant KRAS. Proteomics and CRISPR-CAS9 screens will discover vulnerabilities that will be tested in mouse models and patient-derived xenografts.