About-nci/organization/ccg/funding

CCG Funding Opportunities

Novel Technology Tools to Facilitate Research Using Next Generation Patient-derived Cancer Models

NCI is accepting applications to support the development of "technology tools" that will facilitate the utilization of next-generation cancer models developed by the Human Cancer Models Initiative. Examples of proposed technology tools may include new and/or optimized laboratory methods, reagents, screening read-outs, and/or tools for data processing. RFA-CA-19-055 details.

NCI Genomic Characterization Centers

NCI has published a request for proposals to acquire contractor(s) who will function as Genomic Characterization Centers (GCCs), providing high-resolution, systematic, comprehensive (genome-wide) characterization services of cancer-related genomic alterations. GCCs play a fundamental role in NCI research programs, providing DNA, RNA, and protein characterization services and depositing resulting data in the Genomic Data Commons for public use. Key goals include ensuring that standards are developed, implemented, continually improved, and maintained for genomic characterization services.

Cutting Edge Informatics Tools for Illuminating the Druggable Genome

The overarching goal of this FOA is to add informatics capabilities to the Common Fund program, Illuminating the Druggable Genome (IDG). The IDG consortium's purpose is to facilitate the unveiling of the functions of selected understudied proteins in the Druggable Genome using experimental and informatics approaches. Currently, this research consortium is composed of multiple Data and Resource Generation Centers (DRGCs), a Knowledge Management Center (KMC), and a Resource Dissemination and Outreach Center (RDOC). For more information, see the RFA announcement.

Biospecimen Processing and Storage

The NCI published a funding opportunity announcementExit Disclaimer for two functions of the Biospecimen Core Resource (BCR). The BCR will perform biospecimen collection, processing, and storage for the expanding list of NCI-supported cancer genomic programs and collaborations. The functions of the BCR will be fulfilled by three specialized centers: The Biospecimen Processing Center (BPC), the CCG Biorepository and Archive (CBA) and the Clinical Data Center (CDC). The Clinical Data Center (CDC) will be built through an already existing NCI contract.

The BPC will receive biospecimens from Tissue Source Sites (TSSs), ensure the quality of the tissue and associated data, process the tissue to produce molecular analytes, and collaborate with the CBA and CCG’s Genomic Characterization Centers (GCCs) to support CCG’s genomic research. The CBA will provide long-term storage and archiving of biospecimens received from the BPC.

CTD2 Centers

NCI's Office of Cancer Genomics, a part of the Center for Cancer Genomics, has released a new Funding Opportunity Announcement (FOA). This FOA will continue to support the program Cancer Target Discovery and Development (CTD2, pronounced cee-tee-dee-squared). CTD2 is focused on efforts that advance cancer research by bridging the knowledge gap between the volumes of data generated by comprehensive molecular characterizations and studies of the underlying etiology of cancer development, progression, and/or metastasis. Access the RFA

Generating Tumor-derived Culture Models

A funding opportunity aims to generate novel human tumor-derived culture models that will be made accessible to scientists around the world.

Many cancer cell lines available today have limited utility as cancer models because they lack the complex architecture of human tissue and the genomic and associated clinical information from the original tissue. In an effort to generate improved tumor models, successful vendors will create models that more closely resemble human tissue using novel techniques such as organoids, conditionally reprogrammed cells, or others. The resulting cancer cell lines will be made available to researchers through a distributor. The original tumor and the derived models will be sequenced (under a separate contract) and this information, as well as patient-pertinent clinical data, will be available to researchers through the Genomic Data Commons to serve as valuable tools for the cancer research field.

Genomic Data Analysis Network (GDAN) Centers

The National Cancer Institute (NCI) has awarded funds for three different types (Processing, Visualization, and Specialized) of Genomic Data Analysis Network (GDAN) Centers to support programs of the Center for Cancer Genomics (CCG). The awardees will support the CCG pipeline by providing the bulk of the analysis of the data generated by the Genomic Characterization Centers (GCCs) and the GDAN centers will also work closely with the Analysis Working Groups (AWGs) on each CCG project.