About-cancer/treatment/clinical-trials/thymoma-thymic-carcinoma
Izilingo Zemitholampilo Zokwelapha I-Thymoma ne-Thymic Carcinoma
Izilingo 1-12 kwezingu-12
I-Carboplatin ne-Paclitaxel ene-Ramucirumab noma engenayo ekwelapheni iziguli ezinomdlavuza wasendaweni othuthukile, ophindaphindwayo noma we-metastatic thymic cancer ongasuswa ngokuhlinzwa
Lesi silingo sesigaba II esingahleliwe sihlola ukuthi i-carboplatin ne-paclitaxel isebenza kanjani noma ingenayo i-ramucirumab ekwelapheni iziguli ezinomdlavuza we-thymic osakazekele ezicutshini eziseduze noma kuma-lymph node (athuthukile endaweni), ibuyile (iphindelela), isabalalele kwezinye izindawo body (metastatic) noma ayinakususwa ngokuhlinzwa. Izidakamizwa ezisetshenziselwa ukwelashwa ngamakhemikhali, njenge-carboplatin ne-paclitaxel, zisebenza ngezindlela ezehlukene ukunqanda ukukhula kwamangqamuzana ezinzwa, kungaba ngokubulala amaseli, ngokuwavimba ekuhlukaniseni, noma ngokuwavimba ekusakazeni. Ama-antibody e-monoclonal, afana ne-ramucirumab, angaphazamisa ikhono lamangqamuzana wesimila ukukhula nokukhula. Akukaziwa ukuthi ukunikeza i-carboplatin ne-paclitaxel nge-ramucirumab noma ngaphandle kwayo kuzosebenza kangcono ekwelapheni iziguli ezinomdlavuza we-thymic.
Indawo: izindawo ezingama-254
Isifundo se-XmAb®20717 kuzihloko ezinamaThumba aQinisekile aQinisiwe aKhethiwe
Lesi yisigaba 1, umthamo omningi, ocwaningweni lokukhuphuka kwedosi ukuchaza i-MTD / RD nohlobo lwe-XmAb20717, ukuchaza ukuphepha nokubekezelelana, ukuhlola i-PK kanye ne-immunogenicity, nokuhlola kuqala umsebenzi wokulwa nesimila weXmAb20717 ezifundweni ezikhethiwe izimila eziqinile ezithuthukile.
Indawo: izindawo eziyi-15
I-Nivolumab neVorolanib ekwelapheni iziguli ezinomdlavuza we-Lung non-Small Cell Lung Cancer kanye ne-Refractory Thoracic Tumors.
Lesi sigaba sesivivinyo se-I / II sihlola imiphumela emibi kanye nomthamo omuhle kakhulu we-vorolanib lapho unikezwa ngokuhlangana ne-nivolumab ekwelapheni iziguli ezinomdlavuza ongewona omncane wamangqamuzana wamaphaphu kanye nezicubu ze-thoracic ezingaphenduli ekwelashweni (okukhanyelayo). I-Immunotherapy enama-antibody monoclonal, njenge-nivolumab, ingasiza amasosha omzimba ukuthi ahlasele umdlavuza, futhi ingaphazamisa amandla amangqamuzana e-tumor ukuthi akhule futhi asabalale. IVorolanib ingamisa ukukhula kwamangqamuzana wesimila ngokuvimba amanye ama-enzyme adingekayo ekukhuleni kwamaseli. Ukunikeza i-nivolumab ne-vorolanib kungasebenza kangcono ekwelapheni iziguli ezinomdlavuza ongewona omncane wamangqamuzana wamaphaphu kanye nezicubu ze-thoracic.
Indawo: izindawo ezingu-7
Ukufundwa kwe-SO-C101 ne-SO-C101 ngokuhlanganiswa ne-Pembro ezigulini zabantu abadala ezinezicubu eziqinile / eziqinile zeMetastatic.
I-multicenter open-label phase 1 / 1b Study yokuhlola ukuphepha nokusebenza kokuqala kwe-SO-C101 njenge-monotherapy futhi ihlangene ne-pembrolizumab ezigulini ezinamathumba aqinile akhethiwe / we-metastatic solid
Indawo: izindawo ezi-2
Ukuhlaziywa Okusheshayo Nokuhlolwa Kokuphendula Kwama-Agents Ahlanganisayo Alwa Ne-Plastikhi Kuzilonda Ezingavamile (I-RARE CANCER) Isilingo: RARE 1 Nilotinib nePaclitaxel
Ingemuva: Abantu abanomdlavuza ongajwayelekile bavame ukuba nezindlela zokwelashwa ezinqunyelwe. I-biology yomdlavuza ongavamile ayiqondakali kahle. Abaphenyi bafuna ukuthola ukwelashwa okungcono kwale mdlavuza. Bafuna ukuhlola imishanguzo emi-2, ethathwe ngokwehlukana, esize abantu abanomdlavuza ongajwayelekile. Bafuna ukubona ukuthi ngabe le mithi ihlangene ingenza yini umdlavuza ongavamile ukuncipha noma uyeke ukukhula. Inhloso: Ukufunda ukuthi i-nilotinib ne-paclitaxel kuzozuzisa yini abantu abanomdlavuza ongajwayelekile. Ukufaneleka: Abantu abaneminyaka engu-18 nangaphezulu abanomdlavuza ongajwayelekile, othuthukile othuthukile ngemuva kokuthola ukwelashwa okujwayelekile, noma okungekho ukwelashwa okusebenzayo. Idizayini: Ababambiqhaza bazohlolwa ngomlando wezokwelapha kanye nokuhlolwa komzimba. Bazohlolwa igazi nomchamo. Bazohlolwa ukuhlolwa kokukhulelwa uma kudingeka. Bazoba ne-electrocardiogram ukuhlola izinhliziyo zabo. Bazoba nezikena ze-imaging ukukala izicubu zabo. Ababambiqhaza bazophinda izivivinyo zokuhlola ngesikhathi socwaningo. Abahlanganyeli bazothola i-nilotinib ne-paclitaxel. Izidakamizwa zinikezwa ngemijikelezo yezinsuku ezingama-28. INilotinib iyi-capsule ethathwa ngomlomo kabili ngosuku. I-Paclitaxel izonikezwa ngemithambo yegazi ngomugqa wentambo noma ulayini ophakathi kanye ngesonto emavikini amathathu okuqala omjikelezo ngamunye. Abahlanganyeli bazogcina idayari yemithi. Bazolandela lapho bethatha izidakamizwa zocwaningo kanye nanoma imiphi imiphumela emibi abangaba nayo. Abahlanganyeli bangaba ne-tumor biopsies yokuzikhethela. Ababambiqhaza bangahlala ocwaningweni kuze kube yilapho isifo sabo siba sibi kakhulu noma benemiphumela engemihle engabekezeleleki. Ababambiqhaza bazoba nocingo olulandelwayo cishe ezinsukwini ezingama-30 ngemuva kokuthatha umthamo wokugcina wemithi yokufunda. Abahlanganyeli bazothola i-nilotinib ne-paclitaxel. Izidakamizwa zinikezwa ngemijikelezo yezinsuku ezingama-28. INilotinib iyi-capsule ethathwa ngomlomo kabili ngosuku. I-Paclitaxel izonikezwa ngemithambo yegazi ngomugqa wentambo noma ulayini ophakathi kanye ngesonto emavikini amathathu okuqala omjikelezo ngamunye. Abahlanganyeli bazogcina idayari yemithi. Bazolandela lapho bethatha izidakamizwa zocwaningo kanye nanoma imiphi imiphumela emibi abangaba nayo. Abahlanganyeli bangaba ne-tumor biopsies yokuzikhethela. Ababambiqhaza bangahlala ocwaningweni kuze kube yilapho isifo sabo siba sibi kakhulu noma benemiphumela engemihle engabekezeleleki. Ababambiqhaza bazoba nocingo olulandelwayo cishe ezinsukwini ezingama-30 ngemuva kokuthatha umthamo wokugcina wemithi yokufunda. Abahlanganyeli bazothola i-nilotinib ne-paclitaxel. Izidakamizwa zinikezwa ngemijikelezo yezinsuku ezingama-28. INilotinib iyi-capsule ethathwa ngomlomo kabili ngosuku. I-Paclitaxel izonikezwa ngemithambo yegazi ngomugqa wentambo noma ulayini ophakathi kanye ngesonto emavikini amathathu okuqala omjikelezo ngamunye. Abahlanganyeli bazogcina idayari yemithi. Bazolandela lapho bethatha izidakamizwa zocwaningo kanye nanoma imiphi imiphumela emibi abangaba nayo. Abahlanganyeli bangaba ne-tumor biopsies yokuzikhethela. Ababambiqhaza bangahlala ocwaningweni kuze kube yilapho isifo sabo siba sibi kakhulu noma benemiphumela engemihle engabekezeleleki. Ababambiqhaza bazoba nocingo olulandelwayo cishe ezinsukwini ezingama-30 ngemuva kokuthatha umthamo wokugcina wemithi yokufunda. I-Paclitaxel izonikezwa ngemithambo yegazi ngomugqa wentambo noma ulayini ophakathi kanye ngesonto emavikini amathathu okuqala omjikelezo ngamunye. Abahlanganyeli bazogcina idayari yemithi. Bazolandela lapho bethatha izidakamizwa zocwaningo kanye nanoma imiphi imiphumela emibi abangaba nayo. Abahlanganyeli bangaba ne-tumor biopsies yokuzikhethela. Ababambiqhaza bangahlala ocwaningweni kuze kube yilapho isifo sabo siba sibi kakhulu noma benemiphumela engemihle engabekezeleleki. Ababambiqhaza bazoba nocingo olulandelwayo cishe ezinsukwini ezingama-30 ngemuva kokuthatha umthamo wokugcina wemithi yokufunda. I-Paclitaxel izonikezwa ngemithambo yegazi ngomugqa wentambo noma ulayini ophakathi kanye ngesonto emavikini amathathu okuqala omjikelezo ngamunye. Abahlanganyeli bazogcina idayari yemithi. Bazolandela lapho bethatha izidakamizwa zocwaningo kanye nanoma imiphi imiphumela emibi abangaba nayo. Abahlanganyeli bangaba ne-tumor biopsies yokuzikhethela. Ababambiqhaza bangahlala ocwaningweni kuze kube yilapho isifo sabo siba sibi kakhulu noma benemiphumela engemihle engabekezeleleki. Ababambiqhaza bazoba nocingo olulandelwayo cishe ezinsukwini ezingama-30 ngemuva kokuthatha umthamo wokugcina wemithi yokufunda.
Indawo: Izikhungo Zikazwelonke Zempilo Clinical Centre, eBethesda, eMaryland
I-Pembrolizumab ne-Sunitinib Malate ekwelapheni abahlanganyeli nge-Refractory Metastatic noma i-Unresectable Thymic Cancer
Lesi sigaba sesivivinyo sesi-II sihlola ukuthi i-pembrolizumab ne-sunitinib malate zisebenza kanjani ekwelapheni ababambiqhaza ngomdlavuza we-thymic osabalele kwezinye izindawo emzimbeni noma ongeke ususwe ngokuhlinzwa futhi ungaphenduli ekwelashweni. Ama-antibody e-monoclonal, afana ne-pembrolizumab, angaphazamisa ikhono lamangqamuzana e-tumor ukukhula nokukhula. I-Sunitinib malate ingamisa ukukhula kwamangqamuzana ama-tumor ngokuvimba amanye ama-enzyme adingekayo ekukhuleni kwamaseli. Ukunikeza i-pembrolizumab ne-sunitinib malate kungasebenza kangcono ekwelapheni umdlavuza we-thymic.
Indawo: I- Ohio State University Comprehensive Cancer Center, eColumbus, e-Ohio
I-Pembrolizumab ekwelapheni abahlanganyeli nge-Thymoma engenakulinganiswa noma i-Thymic Cancer
Lesi sigaba sokuhlolwa kwesigaba ngihlola imiphumela yezinhlangothi kanye nomthamo omuhle kakhulu we-pembrolizumab ekwelapheni ababambiqhaza ngomdlavuza we-thymoma noma we-thymic ongasuswa ngokuhlinzwa. I-Immunotherapy enama-antibody monoclonal, njenge-pembrolizumab, ingasiza amasosha omzimba ukuthi ahlasele umdlavuza, futhi ingaphazamisa amandla amangqamuzana e-tumor ukuthi akhule futhi asabalale.
Indawo: MD Anderson Cancer Center, eHouston, Texas
Selinexor ekwelapheni abahlanganyeli nge-Advanced Thymic Epithelial Tumor
Lesi sigaba sesivivinyo sesi-II sihlola ukuthi isebenza kanjani kahle i-selinexor ekwelapheni ababambiqhaza ngesimila se-thymic epithelial esisabalalele kwezinye izindawo emzimbeni. I-Selinexor ingamisa ukukhula kwamangqamuzana wesimila ngokuvimba amanye amaprotheni adingekayo ekukhuleni kwamaseli.
Indawo: izindawo ezi-2
IBintrafusp Alfa (M7824) ezifundweni ezine-Thymoma ne-Thymic Carcinoma
Ingemuva: I-Thymoma ne-thymic carcinoma yizifo ze-thymus. I-Plasma-based chemotherapy iyindlela yokwelapha ejwayelekile yalezi zifo. Kodwa ezimweni eziningi, lesi sifo siyabuya emuva kokwelashwa. Abaphenyi bafuna ukubona ukuthi umuthi omusha ungasiza yini. Inhloso: Ukubona ukuthi i-bintrafusp alfa (M7824) iyindlela yokwelapha ephumelelayo ye-thymoma ne-thymic carcinoma. Ukufaneleka: Abantu abaneminyaka engu-18 nangaphezulu abanomdlavuza we-thymoma noma we-thymic kanye nesifo sabo babuyile noma bathuthuka ngemuva kokwelashwa okungenani ngohlelo olulodwa lokwelashwa ngamakhemikhali oluqukethe iplatinamu, noma benqabile ukwelashwa okujwayelekile Ukwakhiwa: Ababambiqhaza bazohlolwa ngaphansi komthetho ohlukile. Kuzobuyekezwa umlando wabo wezokwelapha, wezokwelapha nowokwelapha. Bazoba ne-tumor biopsy uma bengenaso isampula. Ababambiqhaza bazothola umuthi ocwaningwayo kanye njalo emavikini ama-2 njengokufakwa okufakwa emithanjeni. Ngenxa yalokhu, kufakwa ipayipi elincane lepulasitiki emthanjeni wengalo. Ngesikhathi kwenziwa ucwaningo, ababambiqhaza bazobhekana nalokhu okulandelayo: Ukubuyekezwa kwezokwelapha Ukuhlolwa komzimba ukuhlolwa kwezimpawu zabo kanye nokukwazi kwabo ukwenza imisebenzi yabo ejwayelekile Ukuhlolwa kwegazi nomchamo Iskena sokuhlola imisipha (kusetshenziswa iMRI) Ukuhlolwa kwesimila (kusetshenziswa ukuhlolwa kwe-MRI noma i-CT) kwenhliziyo namaphaphu Ukuhlolwa kwendlala yegilo lendlala Ukuhlolwa kwesikhumba. Abahlanganyeli bangaba ne-tumor biopsies. Amanye amasampula egazi kanye ne-biopsy azosetshenziselwa ukuhlolwa kofuzo. Ababambiqhaza bangathatha umuthi ocwaningwayo kuze kube yilapho isifo sabo siba sibi noma bengakwazi ukubekezelela ukwelashwa. Ababambiqhaza bazoba nokuvakashelwa okulandelayo amasonto ama-2 kanye nama-6 ngemuva kokuyeka ukwelashwa. Ngemuva kwalokho bazoba nokuvakashelwa kwesikhathi eside njalo ezinyangeni ezintathu. Lokhu kungafaka ukuskena kwe-imaging. Ukuvakashelwa kungenziwa ngocingo, kuskenwa (uma kudingeka) kwenziwa ehhovisi lodokotela wabo. Indawo:
Abexinostat kanye nePembrolizumab ekwelapheni iziguli ezine-MSI-High Local Advanced or Metastatic Solid Tumors
Lesi sigaba sokuhlolwa kwesigaba sokuqala sihlola umthamo ongcono kakhulu nemiphumela emibi ye-abexinostat nokuthi isebenza kahle kanjani ngokunikezwa kanye ne-pembrolizumab ekwelapheni iziguli ezinezicubu eziqinile ze-microsatellite (MSI) ezisabalalele ezicutshini eziseduze noma kuma-lymph node (athuthukile endaweni) noma ezinye izindawo emzimbeni (metastatic). I-Abexinostat ingahle imise ukukhula kwamangqamuzana wesimila ngokuvimba amanye ama-enzyme adingekayo ekukhuleni kwamaseli. I-Immunotherapy enama-antibody monoclonal, njenge-pembrolizumab, ingasiza amasosha omzimba ukuthi ahlasele umdlavuza, futhi ingaphazamisa amandla amangqamuzana e-tumor ukuthi akhule futhi asabalale. Ukunikeza i-abexinostat ne-pembrolizumab kungasebenza kangcono ekwelapheni iziguli ezinamathumba aqinile.
Indawo: UCSF Medical Center-Mount Zion, San Francisco, California
I-Oral TrkA Inhibitor VMD-928 Yokwelapha Izilonda Eziqinile Zabadala Abadala noma iLymphoma
Le yi-multicenter, ilebula evulekile, isifundo seSigaba 1 se-VMD-928 esetshenziswa ngomlomo ezifundweni zabantu abadala ezinezicubu eziqinile ezithuthukile noma i-lymphoma ethuthukile noma engaphenduli ekwelashweni okutholakalayo futhi okungekho ukwelashwa okujwayelekile noma okutholakalayo okwelapha
Indawo: City of Hope Isikhungo Somdlavuza Esiphelele, eDuarte, eCalifornia
Isifundo Somshayeli Sokuphenya Umsebenzi Wezokuphepha Nokusebenza Komtholampilo wase-Avelumab (MSB0010718C) eThymoma naseThymic Carcinoma Ngemuva Kokuqhubekela Phambili Kwe-Platinum-based Chemotherapy
Ingemuva: I-Thymoma ne-thymic carcinoma yimidlavuza evela ku-thymus gland. Ukwelashwa ngamakhemikhali okusekwe ePlatinamu ukwelashwa okujwayelekile kubo. Kepha akuvamile, isifo siyabuya futhi abantu badinga ukwelashwa okwengeziwe ukugcina umdlavuza ungakhuli. Isidakamizwa i-Avelumab singasiza amasosha omzimba ukulwa nomdlavuza. Inhloso: Ukuhlola ukuthi i-avelumab iphephile futhi ibekezeleleke kahle yini, futhi iyasebenza ekwelapheni i-thymoma ebuyile noma ephikisayo kanye ne-thymic carcinoma. Ukufaneleka: Abantu abaneminyaka engu-18 nangaphezulu abane-thymoma noma i-thymic carcinoma ebuyile noma ethuthukile ngemuva kwe-plotherapy equkethe i-chemotherapy Design: Ababambiqhaza bazohlolwa nge: - Igazi, umchamo, nokuhlolwa kwenhliziyo - Skena: Balala emshinini othatha izithombe umzimba. - Ukuhlolwa ngokomzimba - Umlando wezokwelapha - I-Biopsy: inaliti isusa ucezu lwesimila. Amasampula angavela kunqubo yangaphambilini, yize kuyinto efiselekayo ukwenza i-biopsy entsha. Abahlanganyeli bazoba nokwelashwa kumijikelezo yamaviki amabili. Zizoqhubeka kuze kube yilapho imiphumela emibi ingabekezeleleki noma isifo sazo siba sibi kakhulu. Ukuvakasha ngezikhathi zesikhathi ezilandelayo kuyadingeka ngephrothokholi ngayinye. Iziguli eziphendula ekwelashweni noma ezinokuqina okuqinile ngemuva kwezinyanga okungenani eziyi-12 zokwelashwa zingahle zithole umuthi wokunciphisa umthamo ukuze ziqhubeke nokwelashwa. - Njalo emavikini amabili: Ababambiqhaza bazothola i-avelumab ngokumnika emthanjeni (IV). Bazothola i-diphenhydramine (benadryl) ne-acetaminophen (tylenol) ngomlomo noma nge-IV ngaphambi kokuthola i-avelumab yokwehlisa amathuba okuthola ukusabela ku-avelumab. Bazohlolwa igazi, umchamo, nokuhlolwa kwenhliziyo ngezikhathi ezithile. - Imijikelezo 4 no-7, bese kuba njalo emavikini ayisithupha: Kuzokwenziwa amaskeni ukubheka ukuncipha noma ukukhula kwesimila. - Umjikelezo 4: Abahlanganyeli bazonikezwa ithuba lokuhlolwa. - amasonto ama-2-4 ngemuva kokuyeka ukwelashwa: Kuzokwenziwa ukuhlolwa kwegazi, umchamo, nenhliziyo. Abahlanganyeli bangahlolwa. - Emasontweni ayishumi ngemuva kokuyeka ukwelashwa: Ukuhlolwa kwegazi, umchamo nokuhlolwa kwenhliziyo. - Cishe izinyanga eziyisithupha ngemuva kokuyeka ukwelashwa, bese kuthi njalo ezinyangeni ezi-3: Ababambiqhaza bazoba nokuskena futhi bangavumela ukuhlolwa kofuzo kumasampula abo egazi nezicubu.
Indawo: Izikhungo Zikazwelonke Zempilo Clinical Centre, eBethesda, eMaryland
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