Mayelana-umdlavuza / ukwelashwa / ukuhlolwa-kwemitholampilo / izifo / i-kaposi-sarcoma / ukwelashwa

Ukwelashwa Kwezilingo Zomtholampilo weKaposi Sarcoma

Ukuhlolwa kwemitholampilo kuyizifundo zocwaningo ezibandakanya abantu. Ukuhlolwa kwemitholampilo kulolu hlu kungokwelashwa kweKaposi sarcoma. Zonke izilingo ohlwini zisekelwa yi-NCI.

Imininingwane eyisisekelo ye-NCI mayelana nokuhlolwa komtholampilo ichaza izinhlobo nezigaba zezilingo nokuthi zenziwa kanjani. Ukuhlolwa komtholampilo kubheka izindlela ezintsha zokuvimbela, ukuthola, noma ukwelapha izifo. Ungahle uthande ukucabanga ngokubamba iqhaza esivivinyweni somtholampilo. Khuluma nodokotela wakho ngosizo lokunquma ukuthi ngabe kukulungele yini.

Izilingo 1-7 kwezingu-7

I-Nivolumab ne-Ipilimumab ekwelapheni iziguli ezine-HIV ezihlobene nokubuyela emuva noma ukubuyisela emuva i-Classical Hodgkin Lymphoma noma ama-Tumors aqinile aMetastatic noma awanakususwa ngokuhlinzwa

Lesi sigaba sokuhlolwa kwesigaba sokuqala sihlola imiphumela emibi kanye nomthamo omuhle kakhulu we-nivolumab lapho unikezwa nge-ipilimumab ekwelapheni iziguli ezine-human immunodeficiency virus (HIV) ezihambisana ne-classical Hodgkin lymphoma ebuyile ngemuva kwesikhathi sokwenza ngcono noma engaphenduli ekwelashweni, noma izicubu eziqinile zisakazekele kwezinye izindawo emzimbeni noma azikwazi ukususwa ngokuhlinzwa. I-Immunotherapy enama-antibody monoclonal, njenge-ipilimumab ne-nivolumab, ingasiza amasosha omzimba ukuthi ahlasele umdlavuza, futhi ingaphazamisa ikhono lamangqamuzana e-tumor ukukhula nokukhula. I-Ipilimumab i-antibody esebenza ngokumelene ne-molecule ebizwa nge-cytotoxic T-lymphocyte antigen 4 (CTLA-4). I-CTLA-4 ilawula ingxenye yamasosha akho omzimba ngokuyivala. I-Nivolumab uhlobo lwe-antibody ecaciselwe ukufa komuntu okuhleliwe 1 (PD-1), iphrotheni elibhekene nokucekelwa phansi kwamaseli omzimba. Ukunikeza i-ipilimumab nge-nivolumab kungasebenza kangcono ekwelapheni iziguli ezine-HIV ezihambisana ne-classical Hodgkin lymphoma noma izicubu eziqinile uma kuqhathaniswa ne-ipilimumab ene-nivolumab iyodwa.

Indawo: izindawo ezingama-28

UNelfinavir Mesylate ekwelapheni iziguli ezineKaposi Sarcoma

Lesi sivivinyo sesigaba sesibili sokuhlola ukuthi i-nelfinavir mesylate isebenza kanjani ekwelapheni iziguli ezineKaposi sarcoma. I-Nelfinavir mesylate ingamisa ukukhula kwamangqamuzana e-tumor ngokuvimba amanye ama-enzyme adingekayo ekukhuleni kwamaseli.

Indawo: izindawo eziyi-11

I-sEphB4-HSA ekwelapheni iziguli ezineKaposi Sarcoma

Lesi sigaba sesibili sokuhlolwa kwesivivinyo se-EphB4-HSA fusion protein (sEphB4-HSA) ekwelapheni iziguli ezineKaposi sarcoma. I-Recombinant EphB4-HSA fusion protein ingavimba ukukhula kwemithambo yegazi enikeza igazi umdlavuza, futhi ingavimbela namaseli womdlavuza ukuthi angakhuli.

Indawo: izindawo eziyi-10

I-Pembrolizumab ekwelapheni iziguli ezine-HIV kanye nokubuyela emuva, ukuphikisa, noma ukusabalalisa ama-Neoplasms amabi

Lesi sigaba sokuhlolwa kwesigaba sokuqala sihlola imiphumela emibi ye-pembrolizumab ekwelapheni iziguli ezine-human immunodeficiency virus (HIV) kanye nama-neoplasms amabi abuyile (abuyele emuva), awaphenduli ekwelashweni (ayaphikisa), noma asabalalise indawo enkulu emzimbeni (kusakazwe). Ama-antibody e-monoclonal, njenge-pembrolizumab, angavimba ukukhula kwesimila noma komdlavuza ngezindlela ezahlukahlukene ngokukhomba amaseli athile. Kungasiza futhi amasosha omzimba ukuthi abulale amangqamuzana omdlavuza.

Indawo: izindawo eziyi-10

I-Intra-lesional Nivolumab ekwelapheni iziguli ezine-Cutaneous Kaposi Sarcoma

Lesi sigaba sokuhlolwa kwesilingo sihlola imiphumela emibi ye-nivolumab ejojowe ngqo ku-lesion nokubona ukuthi isebenza kanjani ekwelapheni iziguli ezine-cutaneous Kaposi sarcoma. I-Immunotherapy enama-antibody monoclonal, njenge-nivolumab, ingasiza amasosha omzimba ukuthi ahlasele umdlavuza, futhi ingaphazamisa amandla amangqamuzana e-tumor ukuthi akhule futhi asabalale.

Indawo: izindawo ezi-2

Umlando we-KSHV Inflammatory Cytokine Syndrome (KICS)

Ingemuva: - I-KSHV inflammatory cytokine syndrome (KICS) yisifo esisanda kuqashelwa esibangelwa yi-Kaposi sarcoma ehambisana ne-herpesvirus (KSHV). Leli gciwane lingadala umdlavuza. Abantu abane-KICS bangaba nezimpawu ezinzima. Kubandakanya umkhuhlane, ukwehla kwesisindo, noketshezi emilenzeni noma esiswini. Abantu abane-KICS bangaba sengozini yokuthola eminye imidlavuza ehambisana ne-KSHV. Le mikhamo ihlanganisa iKaposi sarcoma ne-lymphoma. Ngenxa yokuthi i-KICS yisifo esisanda kukhonjwa, kudingeka ulwazi oluthe xaxa lokuthi lesi sifo sisebenza kanjani nokuthi yini engenziwa ukuselapha. Izinhloso: - Ukuqoqa imininingwane yezofuzo nezokwelapha kubantu abane-KSHV inflammatory cytokine syndrome. Ukufaneleka: - Abantu okungenani abaneminyaka engu-18 abanesifo se-Kaposi sarcoma herpes kanye nezimpawu ezifana nalezo ezibangelwa yi-KICS. Idizayini: - Ababambiqhaza bazoba nokuvakashelwa okufundwayo njalo. Uhlelo luzonqunywa ngabaphenyi bezocwaningo. - Ababambiqhaza bazohlinzeka ngomlando ophelele wezokwelapha futhi bahlolwe ngokuphelele ngokomzimba. Amasampula egazi nomchamo nawo azolandwa. - Abantu abane-KICS abadinga ukwelashwa bangathola ukwelashwa okusha kokuhlola. Lezi zindlela zokwelapha zingafaka phakathi imishanguzo yokulwa namagciwane nemithi yokwelashwa ngamakhemikhali, ngokuya ngesimo sesifo. - Ababambiqhaza bazoba nezifundo zokuthwebula izithombe, ezifana nesifuba x-ray kanye nezikena ze-computed tomography, ukutadisha izicubu. - Umnkantsha we-Bone kanye ne-lymph node biopsies kungenziwa ukuqoqa amasampula wezicubu ukuze afundwe. - Ababambiqhaza abaneKaposi sarcoma bazothathwa izithombe zezilonda zabo. - Abantu abane-KICS abadinga ukwelashwa bangathola ukwelashwa okusha kokuhlola. Lezi zindlela zokwelapha zingafaka phakathi imishanguzo yokulwa namagciwane nemithi yokwelashwa ngamakhemikhali, ngokuya ngesimo sesifo. - Ababambiqhaza bazoba nezifundo zokuthwebula izithombe, ezifana nesifuba x-ray kanye nezikena ze-computed tomography, ukutadisha izicubu. - Umnkantsha we-Bone kanye ne-lymph node biopsies kungenziwa ukuqoqa amasampula wezicubu ukuze afundwe. - Ababambiqhaza abaneKaposi sarcoma bazothathwa izithombe zezilonda zabo. - Abantu abane-KICS abadinga ukwelashwa bangathola ukwelashwa okusha kokuhlola. Lezi zindlela zokwelapha zingafaka phakathi imishanguzo yokulwa namagciwane nemithi yokwelashwa ngamakhemikhali, ngokuya ngesimo sesifo. - Ababambiqhaza bazoba nezifundo zokuthwebula izithombe, ezifana nesifuba x-ray kanye nezikena ze-computed tomography, ukutadisha izicubu. - Umnkantsha we-Bone kanye ne-lymph node biopsies kungenziwa ukuqoqa amasampula wezicubu ukuze afundwe. - Ababambiqhaza abaneKaposi sarcoma bazothathwa izithombe zezilonda zabo. - Umnkantsha we-Bone kanye ne-lymph node biopsies kungenziwa ukuqoqa amasampula wezicubu ukuze afundwe. - Ababambiqhaza abaneKaposi sarcoma bazothathwa izithombe zezilonda zabo. - Umnkantsha we-Bone kanye ne-lymph node biopsies kungenziwa ukuqoqa amasampula wezicubu ukuze afundwe. - Ababambiqhaza abaneKaposi sarcoma bazothathwa izithombe zezilonda zabo.

Indawo: izindawo ezi-2

I-Pomalidomide ngokuhlanganiswa ne-Liposomal Doxorubicin Kubantu Abane-Kaposi Sarcoma Ethuthukile

Ingemuva: I-Kaposi sarcoma (KS) umdlavuza ovame ukubonakala kubantu abane-HIV. Kubangela izilonda. Lokhu kuvame ukuba esikhumbeni kepha kwesinye isikhathi kuma-lymph node, amaphaphu, kanye nomgudu wamathumbu. Abaphenyi bacabanga ukuthi inhlanganisela yezidakamizwa ingasiza ekwelapheni i-KS. Inhloso: Ukuhlola inhlanganisela yemithi elwa nomdlavuza pomalidomide (CC-4047) ne-liposomal doxorubicin (Doxil) kubantu abane-KS. Ukufaneleka: Abantu abaneminyaka engu-18 nangaphezulu nge-KS Design: Ababambiqhaza bazohlolwa nge: Umlando wezokwelapha Imibuzo Yemibuzo Ukuhlolwa komzimba I-X-ray Biopsy Chest: Isampula elincane lezicubu lithathwa ku-KS lesion. Ukuhlolwa kwe-CT okungenzeka Ukuhlolwa okungenzeka kwamaphaphu noma umgudu wamathumbu nge-endoscope: Ithuluzi eliguquguqukayo lihlola ngaphakathi kwesitho. Ababambiqhaza bazothatha izidakamizwa emijikelezweni yamaviki ama-4. Bazothatha i-Doxil nge-IV ngoSuku 1 lomjikelezo ngamunye. Bazothatha amaphilisi e-CC-4047 ngomlomo usuku ngalunye emavikini amathathu okuqala omjikelezo ngamunye. Abahlanganyeli bazoba nokuvakashelwa okuningi: Ngaphambi kokuqala imishanguzo Ukuqala umjikelezo ngamunye Usuku lwe-15 lwemijikelezo emibili yokuqala Ukuvakasha kufaka phakathi ukuphindwa kokuhlolwa kokuhlolwa futhi: Igazi eliningi lidonsa Izithombe zezilonda Ababambiqhaza bazogcina idayari yezidakamizwa. Abahlanganyeli bazothatha i-aspirin noma ezinye izidakamizwa ukuvimbela amahlule egazi. Ababambiqhaza abane-HIV bazoba nemishanguzo ehlangene yokuthithibalisa igciwane lengculazi. Abanye ababambiqhaza bazoba neskena se-PET. Abahlanganyeli bazoqhubeka nokwelashwa inqobo nje uma bekubekezelela futhi i-KS yabo ithuthuka. Ngemuva kokwelashwa, bazoba nokuvakashelwa okuningana okulandelwayo kuze kube yiminyaka emihlanu ... Ngaphambi kokuqala imishanguzo Ukuqala umjikelezo ngamunye Usuku lwe-15 lwemijikelezo emibili yokuqala Ukuvakasha kufaka ukuphinda kokuhlolwa kokuhlolwa futhi: Igazi eliningi lidonsa Izithombe zezilonda Ababambiqhaza bazogcina idayari yezidakamizwa. Abahlanganyeli bazothatha i-aspirin noma ezinye izidakamizwa ukuvimbela amahlule egazi. Ababambiqhaza abane-HIV bazoba nemishanguzo ehlangene yokuthithibalisa igciwane lengculazi. Abanye ababambiqhaza bazoba neskena se-PET. Abahlanganyeli bazoqhubeka nokwelashwa inqobo nje uma bekubekezelela futhi i-KS yabo ithuthuka. Ngemuva kokwelashwa, bazoba nokuvakashelwa okuningana okulandelwayo kuze kube yiminyaka emihlanu ... Ngaphambi kokuqala imishanguzo Ukuqala umjikelezo ngamunye Usuku lwe-15 lwemijikelezo emibili yokuqala Ukuvakasha kufaka ukuphinda kokuhlolwa kokuhlolwa futhi: Igazi eliningi lidonsa Izithombe zezilonda Ababambiqhaza bazogcina idayari yezidakamizwa. Abahlanganyeli bazothatha i-aspirin noma ezinye izidakamizwa ukuvimbela amahlule egazi. Ababambiqhaza abane-HIV bazoba nemishanguzo ehlangene yokuthithibalisa igciwane lengculazi. Abanye ababambiqhaza bazoba neskena se-PET. Abahlanganyeli bazoqhubeka nokwelashwa inqobo nje uma bekubekezelela futhi i-KS yabo ithuthuka. Ngemuva kokwelashwa, bazoba nokuvakashelwa okuningana okulandelwayo kuze kube yiminyaka emihlanu ... Ababambiqhaza abane-HIV bazoba nemishanguzo ehlangene yokuthithibalisa igciwane lengculazi. Abanye ababambiqhaza bazoba neskena se-PET. Abahlanganyeli bazoqhubeka nokwelashwa inqobo nje uma bekubekezelela futhi i-KS yabo ithuthuka. Ngemuva kokwelashwa, bazoba nokuvakashelwa okuningana okulandelwayo kuze kube yiminyaka emihlanu ... Ababambiqhaza abane-HIV bazoba nemishanguzo ehlangene yokuthithibalisa igciwane lengculazi. Abanye ababambiqhaza bazoba neskena se-PET. Abahlanganyeli bazoqhubeka nokwelashwa inqobo nje uma bekubekezelela futhi i-KS yabo ithuthuka. Ngemuva kokwelashwa, bazoba nokuvakashelwa okuningana okulandelwayo kuze kube yiminyaka emihlanu ...

Indawo: Izikhungo Zikazwelonke Zempilo Clinical Centre, eBethesda, eMaryland