Iindidi / ingqondo / isigulana / umntwana-i-cns-atrt-unyango-pdq

Inkqubo yoBuntwana eNdawo yeNervous Atypical Teratoid / Rhabdoid Tumor Treatment (®) -Patient Version

Ulwazi ngokubanzi malunga neNkqubo yaBantwana ePhakamileyo yeNervous System (CNS) yeAtical Teratoid / Rhabdoid Tumor

IINGONGOMA EZIPHAMBILI

• Inkqubo ye-nervous system e-atypical teratoid / rhabdoid tumor sisifo apho iiseli ezinobungozi (zomhlaza) zenza izicwili zobuchopho.

• Olunye utshintsho kwimfuza lunokunyusa umngcipheko we-atypical teratoid / rhabdoid tumor.

• Iimpawu kunye neempawu ze-atypical teratoid / rhabdoid tumor azifani kwizigulana zonke.

• Uvavanyo oluvavanya ubuchopho kunye nentambo yomqolo zisetyenziselwa ukukhangela (fumana) i-CNS atypical teratoid / rhabdoid tumor.

• Ubuntwana be-atypical teratoid / rhabdoid tumor buxilongwa kwaye bunokususwa kuqhaqho.

• Izinto ezithile zichaphazela ukuxela kwangaphambili (ithuba lokufumana kwakhona) kunye nokhetho lonyango.

Inkqubo ye-nervous system e-atypical teratoid / rhabdoid tumor sisifo apho iiseli ezinobungozi (zomhlaza) zenza izicwili zobuchopho.

Inkqubo ye-nervous central (CNS) atypical teratoid / rhabdoid tumor (AT / RT) sisisu esinqabileyo, esikhula ngokukhawuleza kwengqondo kunye nentambo yomqolo. Ihlala ivela kubantwana abaneminyaka emithathu nangaphantsi, nangona inokwenzeka kubantwana abadala nakubantu abadala.

Malunga nesiqingatha sala mathumba enza kwi-cerebellum okanye kwingqondo yengqondo. I-cerebellum yinxalenye yengqondo elawula intshukumo, ibhalansi kunye nokuma komzimba. Ingqondo ilawula ukuphefumla, ukubetha kwentliziyo, kunye neethambo kunye nezihlunu ezisetyenziselwa ukubona, ukuva, ukuhamba, ukuthetha, kunye nokutya. I-AT / RT inokufumaneka nakwezinye iindawo zenkqubo ye-nervous system (ubuchopho kunye nentambo yomgogodla).

I-anatomy yengqondo. Indawo ye-supratentorial (inxalenye ephezulu yengqondo) iqulethe i-cerebrum, i-lateral ventricle kunye ne-ventricle yesithathu (ene-cerebrospinal fluid eboniswe ngombala oluhlaza okwesibhakabhaka), i-choroid plexus, ipineal gland, i-hypothalamus, i-pituitary gland, kunye ne-optic nerve. Indawo yangasemva ye-fossa / indawo engafakwanga amandla (icandelo elisezantsi lengqondo) liqukethe i-cerebellum, i-tectum, i-ventricle yesine, kunye nengqondo yengqondo (i-midbrain, iipon, kunye ne-medulla). I-tentorium yahlulahlula i-supratentorium kwi-infratentorium (ipaneli esekunene). Ukhakhayi kunye ne-meninges zikhusela ubuchopho kunye nentambo yomqolo (ipaneli yasekhohlo).

Esi sishwankathelo sichaza unyango lwezidumbu zokuqala zobuchopho (amathumba aqala kwingqondo). Unyango lwamathumba obuchopho be-metastatic, amathumba abunjwe ziiseli zomhlaza eziqala kwezinye iinxalenye zomzimba kwaye zisasazeke kwingqondo, aligutyungelwanga kwesi sishwankathelo. Ngolwazi oluthe kratya, jonga isishwankathelo se- kuBongo boBuntwana kunye ne-Spinal Cord Tumors Treatment Overview malunga neentlobo ezahlukeneyo zobuchopho bobuntwana kunye ne-spinal cord tumors.

Izidumbu zobuchopho zinokubakho kokubini ebantwaneni nakubantu abadala; nangona kunjalo, unyango lwabantwana lunokwahluka kunonyango lwabantu abadala. Jonga isishwankathelo sonyango lwe- kunyango lwaBantu abaDala oluNyango lweeThumba ukuze ufumane ulwazi oluthe kratya.

Olunye utshintsho kwimfuza lunokunyusa umngcipheko we-atypical teratoid / rhabdoid tumor.

Nantoni na eyandisa umngcipheko wokufumana isifo ibizwa ngokuba yingozi. Ukuba nomngcipheko akuthethi ukuba uza kuba nomhlaza; ukungabinamngcipheko oko akuthethi ukuba awuzukufumana umhlaza. Thetha nogqirha wakho ukuba ucinga ukuba umntwana wakho usengozini.

I-atypical teratoid / rhabdoid tumor inokunxulunyaniswa notshintsho kwi-tumor suppressor genes i-SMARCB1 okanye i-SMARCA4. Imfuza yolu hlobo yenza iproteni enceda ukulawula ukukhula kweseli. Utshintsho kwi-DNA yohlobo lwe-tumor suppressor genes njenge-SMARCB1 okanye i-SMARCA4 inokukhokelela kumhlaza.

Utshintsho kwi-SMARCB1 okanye kwi-SMARCA4 yemfuza inokufunyanwa njengelifa (idluliselwe ukusuka kubazali kuye kwinzala). Xa olu tshintsho lwemfuza luzuzwe njengelifa, amathumba anokuvela kwiindawo ezimbini zomzimba ngaxeshanye (umzekelo, kwingqondo nakwintso). Kwizigulana ezine-AT / RT, ingcebiso ngemfuzo (ingxoxo nengcali eqeqeshiweyo malunga nezifo ezizuzwe njengelifa kunye nemfuneko yokuvavanywa kwemfuza) kunokucetyiswa.

Iimpawu kunye neempawu ze-atypical teratoid / rhabdoid tumor azifani kwizigulana zonke.

Iimpawu kunye neempawu zixhomekeke koku kulandelayo:

• Iminyaka yomntwana.

• Apho lakha khona eli thumba.

Ngenxa yokuba itopical teratoid / rhabdoid tumor ikhula ngokukhawuleza, iimpawu kunye neempawu zinokukhula ngokukhawuleza kwaye zibi ngakumbi kwixesha leentsuku okanye iiveki. Iimpawu kunye neempawu zinokubangelwa yi-AT / RT okanye ngezinye iimeko. Jonga kugqirha womntwana wakho ukuba umntwana wakho unayo nayiphi na kwezi zinto zilandelayo:

• Intloko yentsasa okanye intloko ehambayo emva kokugabha.

• Isicaphucaphu nokugabha.

• Ukulala ngokungaqhelekanga okanye utshintsho kwinqanaba lomsebenzi.

• Ukuphulukana nokulingana, ukunqongophala kokulungelelanisa, okanye ingxaki yokuhamba.

• Ukwandisa ubungakanani beentloko (kwiintsana).

Uvavanyo oluvavanya ubuchopho kunye nentambo yomqolo zisetyenziselwa ukukhangela (fumana) i-CNS atypical teratoid / rhabdoid tumor.

Ezi mvavanyo zilandelayo kunye neenkqubo zinokusetyenziswa:

• Uvavanyo lomzimba kunye nembali: Uvavanyo lomzimba ukukhangela iimpawu zempilo ngokubanzi, kubandakanya nokujonga iimpawu zesifo, ezinje ngamaqhuma okanye nayiphi na into ebonakala ingaqhelekanga. Imbali yemikhwa yempilo yesigulana kunye nezifo zangaphambili kunye nonyango ziya kuthathwa.

• Uvavanyo lwe-Neurological: Uthotho lwemibuzo kunye novavanyo lokujonga ubuchopho, intambo yomqolo kunye nokusebenza kwentliziyo. Uvavanyo lujonga imeko yomntu ngokwengqondo, ulungelelwaniso, kunye namandla okuhamba ngesiqhelo, kunye nendlela esebenza ngayo izihlunu, imizwa kunye nengqondo. Oku kunokubizwa ngokuba luvavanyo lwe-neuro okanye uvavanyo lwe-neurologic.

• I-MRI (imaging resonance imaging): Inkqubo esebenzisa umazibuthe, amaza erediyo kunye nekhompyuter ukwenza uthotho lwemifanekiso eneenkcukacha zeendawo ezingaphakathi kwengqondo kunye nomqolo. Le nkqubo ikwabizwa ngokuba yimifanekiso yenyukliya yokujonga umfanekiso (i-NMRI).

• Ukugqobhoza iLumbar: Inkqubo esetyenziselwa ukuqokelela i-cerebrospinal fluid (CSF) ukusuka kumqolo womqolo. Oku kwenziwa ngokubeka inaliti phakathi kwamathambo amabini emqolo kunye nakwi-CSF ejikeleze intambo yomqolo kunye nokususa isampulu yolwelo. Isampulu ye-CSF ihlolwe phantsi kwemicroscope ngeempawu zeeseli zethumba. Isampulu inokujongwa kwakhona kwixabiso leprotein kunye neswekile. Inani elingaphezulu kweprotheyini eliqhelekileyo okanye elisezantsi kunesiqhelo iswekile inokuba luphawu lwethumba. Le nkqubo ikwabizwa ngokuba yi-LP okanye impompo yomqolo.

• Ukuvavanywa kohlobo lwe-SMARCB1 kunye ne-SMARCA4: Uvavanyo lwelabhoratri apho kuvavanywa khona isampulu yegazi okanye izicwili zotshintsho oluthile kuhlobo lweSMARCB1 kunye neSMARCA4.

Ubuntwana be-atypical teratoid / rhabdoid tumor buxilongwa kwaye bunokususwa kuqhaqho.

Ukuba oogqirha bacinga ukuba kunokubakho ithumba ebuchotsheni, kungenziwa i-biopsy ukususa isampulu yethishu. Kwiithumba ebuchotsheni, i-biopsy yenziwa ngokususa inxenye yokakayi kunye nokusebenzisa inaliti ukususa isampulu yethishu. Ugqirha wezifo ujonga izicwili phantsi kwemicroscope ukukhangela iiseli zomhlaza. Ukuba iiseli zomhlaza zifunyenwe, ugqirha unokususa i-tumor eninzi ngokukhuselekileyo ngexesha lotyando olufanayo. Ugqirha wezifo ujonga iiseli zomhlaza ukufumanisa uhlobo lwethumba lobuchopho. Kuhlala kunzima ukususa ngokupheleleyo i-AT / RT ngenxa yendawo esikuyo ithumba ebuchotsheni kwaye ngenxa yokuba inokuba sele isasazekile ngexesha lokuchongwa.

I-Craniotomy: Kuvulwa ukakayi kwaye kususwe iqhekeza lekhakhayi ukubonisa indawo yengqondo.

Olu vavanyo lulandelayo lunokwenziwa kwisampulu yethishu esusiweyo:

• I-Immunohistochemistry: Uvavanyo lwaselebhu olusebenzisa ii-antibodies ukukhangela ii-antigen ezithile (iimpawu) kwisampulu yesicwili somguli. Amachiza omzimba ahlala enxulunyaniswa ne-enzyme okanye idayi ye-fluorescent. Emva kokuba ii-antibodies zibophelela kwi-antigen ethile kwisampulu yethishu, i-enzyme okanye idayi iyasebenza, kwaye i-antigen iya kuthi emva koko ibonwe phantsi kwemicroscope. Olu hlobo lovavanyo lusetyenziselwa ukufumanisa isifo somhlaza kunye nokunceda uxelele olunye uhlobo lomhlaza kolunye uhlobo lomhlaza.

Izinto ezithile zichaphazela ukuxela kwangaphambili (ithuba lokufumana kwakhona) kunye nokhetho lonyango.

Ukuxela kwangaphambili (ithuba lokufumana kwakhona) kunye nokhetho lonyango luxhomekeke koku kulandelayo:

• Nokuba kukho utshintsho oluthile lofuzo.

• Ubudala bomntwana.

• Isixa sethumba esisele emva kotyando.

• Nokuba umhlaza usasazekile kwezinye iinxalenye zenkqubo ye-nervous system (ubuchopho kunye nentambo yomqolo) okanye kwizintso ngexesha lokuchongwa.

Amanqanaba obuntwana be-CNS Atypical Teratoid / Rhabdoid Tumor

IINGONGOMA EZIPHAMBILI

• Akukho nkqubo yenkqubo yokulinganisa esemgangathweni yenkqubo ye-nervous system ye-atypical teratoid / rhabdoid tumor.

Akukho nkqubo yenkqubo yokulinganisa esemgangathweni yenkqubo ye-nervous system ye-atypical teratoid / rhabdoid tumor.

Ubungakanani okanye ukusasazeka komhlaza kuhlala kuchazwa njengezigaba. Akukho nkqubo yenkqubo yokulinganisa esemgangathweni yenkqubo ye-nervous system ye-atypical teratoid / rhabdoid tumor.

Kunyango, eli thumba liqokelelwe njengophononongo olusandul 'ukuvela okanye okuphindaphindayo. Unyango luxhomekeke koku kulandelayo:

• Ubudala bomntwana.

• Uhlala kangakanani umhlaza emva kotyando lokususa ithumba.

Iziphumo ezivela kule nkqubo ilandelayo zikwasetyenziselwa ukucwangcisa unyango:

• Uvavanyo lwe-Ultrasound: Inkqubo apho amaza esandi aphakamileyo amandla (i-ultrasound) ehlaselwa kwizicubu zangaphakathi okanye kwizitho, ezinjengezintso, kwaye zenza i-echoes. Iingqungquthela zenza umfanekiso wezicubu zomzimba ezibizwa ngokuba yi-sonogram. Umfanekiso unokuprintwa ukuze ujongwe kamva. Le nkqubo yenziwa ukujonga amathumba anokuthi abekho kwizintso.

Unyango ngoKhetho lonyango

IINGONGOMA EZIPHAMBILI

• Kukho iintlobo ezahlukeneyo zonyango kwizigulana ezinesistim ye-nervous system ye-atypical teratoid / rhabdoid tumor.

• Abantwana abanesifo somzimba esine-atypical teratoid / rhabdoid kufuneka unyango lwabo lucwangciswe liqela lababoneleli ngezempilo abaziingcali

ukunyanga umhlaza ebantwaneni.

• Amathumba obuchopho ebuntwaneni anokubangela iimpawu okanye iimpawu eziqala ngaphambi kokuba umhlaza ubhaqwe kwaye uqhubeke kangangeenyanga okanye iminyaka.

• Unyango lwenkqubo ye-nervous system esembindini kwi-teratoid / rhabdoid tumors inokubangela iziphumo ebezingalunganga.

• Iindlela ezine zonyango zisetyenzisiwe:

• Ugqirha

• Unyango ngamayeza

• Unyango ngemitha

• I-dose ephezulu ye-chemotherapy kunye nokufakelwa kweseli

• Iindidi ezintsha zonyango ziyavavanywa kuvavanyo lweklinikhi.

• Unyango ekujoliswe kulo

• Izigulana zinokufuna ukucinga ngokuthatha inxaxheba kuvavanyo lweklinikhi.

• Izigulana zinokungena kuvavanyo lweklinikhi ngaphambi, ngexesha, okanye emva kokuqala unyango lomhlaza.

• Iimvavanyo zokulandelela zisenokufuneka.

Kukho iintlobo ezahlukeneyo zonyango kwizigulana ezinesistim ye-nervous system ye-atypical teratoid / rhabdoid tumor.

Iindlela ezahlukeneyo zonyango ziyafumaneka kwizigulana ezinesistim ye-nervous system atypical teratoid / rhabdoid tumor (AT / RT). Unyango lwe-AT / RT luhlala luvavanyo lweklinikhi. Uvavanyo lweklinikhi yonyango luphononongo olwenzelwe ukunceda ukuphucula unyango lwangoku okanye ukufumana ulwazi kunyango olutsha kwizigulana ezinomhlaza.

Uvavanyo lwezonyango lwenzeka kwiindawo ezininzi zelizwe. Ulwazi malunga novavanyo oluqhubekayo lwezonyango luyafumaneka kwiwebhusayithi ye-NCI. Ukukhetha olona nyango lufanelekileyo lomhlaza sisigqibo esibandakanya isigulana, usapho kunye neqela lokhathalelo lwempilo.

Abantwana abanesifo somzimba esine-atypical teratoid / rhabdoid kufuneka unyango lwabo lucwangciswe liqela lababoneleli ngezempilo abaziingcali kunyango lomhlaza ebantwaneni.

Unyango luya kujongwa yi-oncologist yabantwana, ugqirha ogxile ekunyangeni abantwana abanomhlaza. I-oncologist yabantwana isebenza nabanye ababoneleli ngononophelo lwempilo yabantwana abaziingcali ekunyangeni abantwana abanesifo somhlaza senkqubo ye-nervous kwaye begxile kwiindawo ezithile zamayeza. Oku kunokubandakanya ezi ngcali zilandelayo:

• Ugqirha wabantwana.

• I-neurosurgeon yabantwana.

• Imitha ye-oncologist.

• Ingcali yonyango.

• Ingcali yomongikazi wabantwana.

• Ingcali yokuvuselela.

• Ingcali yeengqondo.

• Unontlalontle.

• I-Geneticist okanye umcebisi wezofuzo.

Amathumba obuchopho ebuntwaneni anokubangela iimpawu okanye iimpawu eziqala ngaphambi kokuba umhlaza ubhaqwe kwaye uqhubeke kangangeenyanga okanye iminyaka.

Iimpawu okanye iimpawu ezibangelwa lithumba zingaqala ngaphambi kokuxilongwa. Ezi mpawu okanye iimpawu zingaqhubeka iinyanga okanye iminyaka. Kubalulekile ukuba uthethe noogqirha bomntwana wakho malunga neempawu okanye iimpawu ezibangelwa lithumba eliya kuqhubeka emva konyango.

Unyango lwenkqubo ye-nervous system esembindini kwi-teratoid / rhabdoid tumors inokubangela iziphumo ebezingalunganga.

Ngolwazi malunga neziphumo ebezingalindelekanga eziqala ngexesha lonyango lomhlaza, jonga iphepha lethu Iziphumo ezingalunganga.

Iziphumo ebezingalindelekanga ezivela kunyango lomhlaza eziqala emva konyango kwaye ziqhubeke iinyanga okanye iminyaka zibizwa ngokuba ziziphumo ezifike kade. Iziphumo zokunyanga komhlaza zingabandakanya oku kulandelayo:

• Iingxaki zomzimba.

• Utshintsho kwiimvakalelo, iimvakalelo, ukucinga, ukufunda, okanye inkumbulo.

• Umhlaza wesibini (iintlobo ezintsha zomhlaza).

Ezinye iziphumo ezinokufika emva kwexesha zinokunyangwa okanye zilawulwe. Kubalulekile ukuba uthethe noogqirha bomntwana wakho malunga nefuthe unyango lomhlaza olunokuba nalo emntwaneni wakho. (Jonga isishwankathelo se- malunga neZiphumo eziMva zaNyango zoMhlaza woMntwana ngolwazi oluthe kratya).

Iindlela ezine zonyango zisetyenzisiwe:

Ugqirha

Utyando lusetyenziselwa ukufumanisa nokunyanga i-CNS itopical teratoid / rhabdoid tumor. Jonga icandelo loLwazi ngokubanzi kwesi sishwankathelo.

Emva kokuba ugqirha ewususile wonke umhlaza onokubonakala ngexesha lotyando, uninzi lwezigulana ziya kunikwa ichemotherapy kwaye mhlawumbi nonyango lwemitha emva kotyando lokubulala naziphi na iiseli zomhlaza ezisele. Unyango olunikezwe emva kotyando, ukunciphisa umngcipheko wokuba umhlaza ubuye kwakhona, lubizwa ngokuba lunyango oluncedisayo.

Unyango ngamayeza

I-Chemotherapy yonyango lomhlaza olusebenzisa iziyobisi ukunqanda ukukhula kweeseli zomhlaza, nokuba zibulale iiseli okanye uziyekise ekwahlukaneni.

• Xa i-chemotherapy ibekwa ngqo kwi-cerebrospinal fluid, ilungu, okanye indawo yomzimba efana nesisu, amachiza ikakhulu achaphazela iiseli zethumba kwezo ndawo (chemotherapy yengingqi). Amayeza aqhelekileyo amachiza e-anticancer anikezwe ngomlomo okanye emthanjeni ukunyanga iingqondo kunye nomqolo wentambo yomqolo ayinakuwela isithintelo segazi-nengqondo kwaye ifike kwithumba. Amachiza e-anticancer afakwe kulwelo lwe-cerebrospinal fluid ayakwazi ukufikelela kwi-tumor. Oku kubizwa ngokuba yi-intrathecal chemotherapy.

• Xa i-chemotherapy ithathwa ngomlomo okanye ifakwe kwi-vein okanye kwimisipha, amachiza angena kwigazi kwaye anokufikelela kwiiseli zomzimba kuwo wonke umzimba (systemic chemotherapy). Amayeza aphakamileyo amayeza athile anika umdla emthanjeni anokuwela isithintelo segazi-lobuchopho aze afike kwithumba.

Unyango ngemitha

Unyango ngemitha lunyango olusebenzisa amandla e-x-reyi okanye ezinye iintlobo zemitha yokubulala iiseli zomhlaza okanye ukuzigcina zikhula. Zimbini iintlobo zonyango lwe-radiation:

• Unyango lwangaphandle lwemitha lusebenzisa umatshini ngaphandle komzimba ukuthumela imitha kumhlaza.

• Unyango lwangaphakathi lwemitha lusebenzisa into enemitha ye-radio etywinwe kwiinaliti, iimbewu, iingcingo, okanye iicatheters ezibekwe ngqo okanye kufutshane nomhlaza.

Indlela unyango lwe-radiation olunikezelwa ngayo ixhomekeke kuhlobo lwethumba eliphathwayo kunye nokuba sele lisasazekile na. Unyango lwangaphandle lwemitha lunokunikwa kwingqondo nakwimithambo yomqolo.

Ngenxa yokuba unyango lwe-radiation lunokuchaphazela ukukhula kunye nokukhula kwengqondo kubantwana abancinci, ngakumbi abantwana abaneminyaka emithathu okanye engaphantsi, idosi yonyango lwemitha inokuba sezantsi kunabantwana abadala.

I-dose ephezulu ye-chemotherapy kunye nokufakelwa kweseli

Amanqanaba aphezulu e-chemotherapy anikezelwa ukubulala iiseli zomhlaza. Iiseli ezisempilweni, kubandakanya iiseli ezenza igazi, nazo ziyatshatyalaliswa lunyango lomhlaza. Ukufakelwa kweseli kwistem kunyango endaweni yeeseli ezenza igazi. Iiseli zeziqu (iiseli zegazi ezingafakwanga) ziyasuswa egazini okanye kumongo wethambo wesigulana okanye somnikeli kwaye zibandisiwe kwaye zigcinwe. Emva kokuba isiguli sigqibe i-chemotherapy, iiseli ezigciniweyo ezigciniweyo ziyanyibilika kwaye zibuyiselwe kwisigulana ngokufakwa. Ezi seli ze-stem ziphinde zafakwa zikhula ziye (kwaye zibuyisele) iiseli zegazi lomzimba.

Iindidi ezintsha zonyango ziyavavanywa kuvavanyo lweklinikhi.

Eli candelo lesishwankathelo lichaza unyango olufundwayo kuvavanyo lweklinikhi. Isenokungakhankanyi lonke unyango olutsha olufundwayo. Ulwazi malunga novavanyo lweklinikhi luyafumaneka kwiwebhusayithi yeNCI.

Unyango ekujoliswe kulo

Unyango ekujoliswe kulo luhlobo lonyango olusebenzisa iziyobisi okanye ezinye izinto ukuhlasela iiseli ezithile zomhlaza. Unyango ekujoliswe kulo lubangela ukwenzakala okuncinci kwiiseli eziqhelekileyo kunonyango lwechemotherapy okanye unyango ngemitha. Unyango ekujoliswe kulo luyafundwa kunyango lwenkqubo ephindaphindayo yobuntwana kwi-teratoid / rhabdoid tumor.

Izigulana zinokufuna ukucinga ngokuthatha inxaxheba kuvavanyo lweklinikhi.

Kwezinye izigulana, ukuthatha inxaxheba kuvavanyo lweklinikhi kunokuba lolona khetho lonyango lufanelekileyo. Uvavanyo lwezonyango luyinxalenye yenkqubo yophando ngomhlaza. Uvavanyo lwezonyango luyenziwa ukufumanisa ukuba unyango lomhlaza olutsha lukhuselekile kwaye luyasebenza okanye lungcono kunonyango oluqhelekileyo.

Uninzi lonyango oluqhelekileyo lwanamhlanje lomhlaza lusekwe kuvavanyo lweklinikhi lwangaphambili. Izigulana ezithatha inxaxheba kuvavanyo lweklinikhi zingafumana unyango olusemgangathweni okanye zibe phakathi kwabokuqala ukufumana unyango olutsha.

Izigulana ezithatha inxaxheba kuvavanyo lweklinikhi zikwanceda ukuphucula indlela umhlaza oza kunyangwa ngayo kwixa elizayo. Nokuba uvavanyo lwezonyango alukhokeleli kunyango olusebenzayo, bahlala bephendula imibuzo ebalulekileyo kwaye bancedisa ukuqhubela phambili uphando.

Izigulana zinokungena kuvavanyo lweklinikhi ngaphambi, ngexesha, okanye emva kokuqala unyango lomhlaza.

Olunye uvavanyo lwezonyango lubandakanya kuphela izigulana ezingekafumani unyango. Olunye uvavanyo lokuvavanywa kunyango kwizigulana ezinomhlaza ongakhange ubengcono. Kukwakho nezilingo zeklinikhi ezivavanya iindlela ezintsha zokumisa umhlaza ekubuyeleni (ekubuyeni) okanye ukunciphisa iziphumo ebezingalindelekanga zonyango lomhlaza.

Uvavanyo lwezonyango lwenzeka kwiindawo ezininzi zelizwe. Ulwazi malunga novavanyo lweklinikhi oluxhaswe yi-NCI lunokufumaneka kwiphepha lewebhu le-NCI. Uvavanyo lwezonyango oluxhaswa yiminye imibutho lunokufumaneka kwiwebhusayithi yeClinicalTrials.gov.

Iimvavanyo zokulandelela zisenokufuneka.

Olunye uvavanyo olwenziweyo lokufumanisa umhlaza lunokuphindwa. Olunye uvavanyo luya kuphindwa ukuze kubonwe ukuba lusebenza njani unyango. Izigqibo malunga nokuqhubeka, ukutshintsha, okanye ukuyeka unyango zinokusekwa kwiziphumo zolu vavanyo.

Ezinye zeemvavanyo ziya kuqhubeka ukwenziwa amaxesha ngamaxesha emva kokuba unyango luphelile. Iziphumo zolu vavanyo zingabonisa ukuba imeko yomntwana wakho itshintshile okanye ukuba umhlaza ubuye wabuya (buyela). Olu vavanyo ngamanye amaxesha lubizwa ngokuba luvavanyo olulandelayo okanye ukuhlolwa.

Iinketho zonyango kunyango olusandula ukufumanisa isifo sobuntwana kwi-CNS Atypical Teratoid / Rhabdoid Tumor

IINGONGOMA EZIPHAMBILI

• Akukho lonyango luqhelekileyo kwizigulana ezinesistim ye-nervous system ye-atypical teratoid / rhabdoid tumor.

• Indibaniselwano yonyango isetyenziselwa abaguli abane-atypical teratoid / rhabdoid tumor.

Ngolwazi malunga nonyango oludweliswe ngezantsi, jonga kwiCandelo loKhetho ngokujonga uKhetho.

Akukho lonyango luqhelekileyo kwizigulana ezinesistim ye-nervous system ye-atypical teratoid / rhabdoid tumor.

Indibaniselwano yonyango isetyenziselwa abaguli abane-atypical teratoid / rhabdoid tumor.

Ngenxa yokuba i-atypical teratoid / rhabdoid tumor (AT / RT) ikhula ngokukhawuleza, indibaniselwano yonyango ihlala inikwa. Emva kotyando lokususa ithumba, unyango lwe-AT / RT lunokubandakanya ukudityaniswa koku kulandelayo:

• Unyango ngamayeza.

• Unyango ngemitha.

• I-dose ephezulu ye-chemotherapy kunye nokufakelwa kweseli.

Uvavanyo lweklinikhi yonyango olutsha kufuneka luqwalaselwe kwizigulana ezinesifo esitsha sokufumanisa isifo se-teratoid / rhabdoid

Sebenzisa uvavanyo lwethu lweklinikhi ukufumana ulingo lweklinikhi oluxhaswayo lwekliniki olwamkela izigulana. Unokukhangela izilingo ngokusekwe kuhlobo lomhlaza, ubudala besigulana, kwaye nokuba zenziwa phi izilingo. Ulwazi ngokubanzi malunga novavanyo lweklinikhi luyafumaneka.

Iinketho zonyango kunyango lwe-CNS oluHlaziyiweyo lweAtypical Teratoid / Rhabdoid Tumor

Ngolwazi malunga nonyango oludweliswe ngezantsi, jonga kwiCandelo loKhetho ngokujonga uKhetho.

Akukho lunyango lusemgangathweni kwizigulana ezinenkqubo ephindaphindayo yobuntwana kwi-teratoid / rhabdoid tumor. Unyango lunokubandakanya oku kulandelayo:

• Uvavanyo lweklinikhi yonyango ekujoliswe kulo.

• Uvavanyo lweklinikhi olujonga isampulu yethumba lesigulana kutshintsho oluthile kwimfuza. Uhlobo lonyango ekujoliswe kulo oluya kunikwa isigulana luxhomekeke kuhlobo lotshintsho lwemfuza.

Sebenzisa uvavanyo lwethu lweklinikhi ukufumana ulingo lweklinikhi oluxhaswayo lwekliniki olwamkela izigulana. Unokukhangela izilingo ngokusekwe kuhlobo lomhlaza, ubudala besigulana, kwaye nokuba zenziwa phi izilingo. Ulwazi ngokubanzi malunga novavanyo lweklinikhi luyafumaneka.

Ukufunda okungakumbi malunga ne-CNS yoBuntwana kwi-Atypical Teratoid / Rhabdoid Tumor kunye nezinye iZimvo zeBongo zaBantwana

Ngolwazi oluthe kratya malunga nenkqubo ye-nervous central system atypical teratoid / rhabdoid tumor kunye nezinye izicubu zobuchopho babantwana, bona oku kulandelayo:

• Iintsholongwane zeBongo leTumor Consortium (PBTC) Phuma kwisichaso

Ngolwazi oluthe kratya lomhlaza wabantwana kunye nezinye izixhobo zomhlaza ngokubanzi, jonga oku kulandelayo:

• Malunga noMhlaza

• Umhlaza wabantwana

• Unyango lokuKhangela uMhlaza waBantwanaPhuma kwiNgcazelo yokuzihlangula

• Iziphumo zokugqibela zonyango lweCancer yoMntwana

• Abafikisayo kunye naBantu abaDala abaDala abanomhlaza

• Abantwana abanomhlaza: Isikhokelo sabazali

• Umhlaza kuBantwana nakwishumi elivisayo

• Ukuqokelela

• Ukujamelana noMhlaza

• Imibuzo yokubuza ugqirha wakho malunga neCancer

• Abasindileyo kunye nabaNonopheli