Uphando / iindawo / izilingo zeklinikhi / i-nctn

I-NCTN: INethiwekhi yeNational Clinical Trials Network

Khangela le bheji kwimibutho yenethiwekhi kunye namaziko. Kuthetha ukuba banikwe isibonelelo yiNational Cancer Institute (NCI) njengelungu leNCI National Clinical Trials Network (NCTN).

Inethiwekhi yeNational Clinical Trials Network (NCTN) yingqokelela yemibutho kunye neeklinikhi eziququzelela kwaye zixhase izilingo zomhlaza kumaziko angaphezulu kwama-2 200 e-United States, Canada, nakwamanye amazwe. I-NCTN ibonelela ngesixhobo sonyango oluxhaswe ngemali yi-NCI kunye nezilingo eziphambili ze-imaging ukuphucula impilo yabantu abanomhlaza.

Uvavanyo lweklinikhi lwe-NCTN lunceda ukuseka imigangatho emitsha yokhathalelo, ukuseta inqanaba lokuvunywa kwonyango olutsha nguLawulo lokutya kunye noLawulo lweziyobisi, kuvavanye iindlela zonyango ezintsha, kunye nokuqinisekisa ii-biomarkers ezintsha.

I-NCI isungule inani lezilingo nge-NCTN, kubandakanya:

• I-ALCHEMIST: Ukuchongwa kweMakethi yokuCebisa uMhlaza wemiphunga yokuLungisa kunye nokuLandelwa kovavanyo

• I-DART: I-Anti-CTLA-4 kunye ne-Anti-PD-1 Blockade kuvavanyo lweThumba eliNqabileyo

• I-Lung-MAP: IsiGaba II / III se-Biomarker-Driven Master Protocol yoNyango lweSibini loNyango lwawo onke amaQonga aPhucukileyo angamaCancer

• I-NCI-MATCH: Uhlalutyo lweMolekyuli yoNyango lweNyango kubantu abadala abanomhlaza ophezulu

• I-NCI-COG yabantwana MATCH: Uhlalutyo lweMolekyuli yoNyango lweNyango yabantwana kunye nabantu abadala abancinci abanomhlaza ophezulu

• I-NCI-NRG ALK Protocol Master: Uvavanyo oluqhutywa yi-biomarker kwizigulana ze-NSCLC ezinganyangekiyo ngaphambili ze-ALK

Amaqela eNethiwekhi kunye neziXhobo zawo zeNkxaso

Ubume bombutho womnatha bulungele ukukhangela inani elikhulu lezigulana ukufumana abo banamathumba abonisa iimpawu zeemolekyuli ezibanika elona thuba liphezulu lokuphendula kunyango olujolise kuko. Oogqirha kunye nezigulana zabo, imenyu yezilingo ezibalulekileyo ziyafumaneka kwilizwe liphela, kwizixeko ezikhulu kunye noluntu oluncinci ngokufanayo. I-NCTN ibonelela ngokufikelela kweyona ndlela ibalaseleyo yokufumana uninzi oluqhelekileyo kwaye, ngokuthe gabalala, nkqu nomhlaza onqabileyo.

Ukonganyelwa kwe-NCTN-ulwakhiwo lombutho, inkxaso-mali, kunye nomkhombandlela wexesha elide-uphantsi kolawulo lweeKlinikhi zovavanyo kunye neKomiti yokuCebisa ngoPhando ngoguqulo (CTAC). Le komiti yengcebiso yomanyano iqulunqwe ziingcali zovavanyo lweklinikhi, abameli beshishini, kunye nabameli babaguli kulo lonke ilizwe kwaye babonelela ngezindululo kumlawuli we-NCI.

Ulwakhiwo lwe-NCTN lubandakanya amaqela amahlanu e-US Network kunye ne-Canada yokuSebenzisana kweNatical Clinical Trials Network. Ubulungu kwiqela ngalinye le-NCTN lisekwe kwiikhrayitheriya ezithile kwiqela ngalinye. Iindawo zinokuba zeqela elingaphezulu kwelinye, kwaye nokuba lilungu kwiqela elinye kuvumela indawo ukuba ithathe inxaxheba kwizilingo ezikhokelwa lilo naliphi na iqela le-NCTN abafanele ukuba baphande ngalo. Ngenxa yoko, abaphandi abavela kwi-LAPS, i-NCORP, amanye amaziko emfundo, iinkqubo zoluntu, kunye namalungu aphesheya ahambelana namaqela eNethiwekhi banokubhalisa bonke abaguli kuvavanyo lwe-NCTN. Uvavanyo lwezonyango olukhokelwa ngamaqela e-NCTN anokufumana inkxaso kwiqela le-IROC, i-ITSAs, kunye neebhanki zethishu, ngokweemfuno zesayensi zezilingo.

Amaqela eNethiwekhi

I-NCTN inamaqela abantu abadala abane kunye neqela elinye elikhulu elijolise ikakhulu kumhlaza womntwana. Ulwakhiwo lukwabandakanya iNethiwekhi yokuNxibelelana kweKlinikhi yokuNxibelelana kweKlinikhi. Amaqela amahlanu e-US Network ngala:

• Umdibaniso wovavanyo lweklinikhi kwi-OncologyExit Disclaimer

• Iqela le-ECOG-ACRIN leCandelo loPhando ngeCancerPhuma kwi-Disclaimer

• I-NRG OncologyExit Isikhanyeli

• SWOGExit Ukuzikhupha

• Iqela le-Oncology yaBantwana (COG) Phuma kwi-Disclaimer

Amaqela ase-US ngalinye axhaswa ngemali ngamabhaso amabini ahlukeneyo-elinye lokuxhasa ukusebenza kweNethiwekhi kunye nelinye lokuxhasa iZiko leeNkcukacha-manani noLawulo lweDatha. Amaziko okuSebenza anoxanduva lokuphucula iinkqubo ezintsha kunye nokulawula ezomthetho, ezezimali, ubulungu kunye neekomiti zenzululwazi zeqela ngalinye. Amaziko eSitatistiki anoxanduva lokulawulwa kwedatha nohlalutyo, ukulungiswa kwemibhalo ebhaliweyo, kunye nokubeka iliso kukhuseleko, ukongeza ekuncedeni kuyilo lwetyala kunye nophuhliso.

Amahlakani eQela leNethiwekhi laseCanada namaQela eNethiwekhi aseMelika ekuqhubeni ukhetho, isigaba sokugqibela, izilingo zeklinikhi ezininzi. Iqela leNethiwekhi laseCanada yile:

• Iqela laseCanada lovavanyo lweCancer (CCTG) Phuma kwisichaso

UkuSebenza kweNethiwekhi kunye namaZiko eSitatisti kwiqela ngalinye le-NCTN ahlukile ngokwendawo kodwa asebenza ngokusondeleleneyo. Bahlala bekho kwiziko lezemfundo elibonelele "ngendlu" iqela; Nangona kunjalo, kumatyeli aliqela, iziko likwindawo yokuzimela exhaswa ngemali ngesiseko esingenzi nzuzo. Ukwahluka okuphela koku kungasentla yiCanada yaseKhanada yokuSebenza yokuNxibelelana kweeKlinikhi zoLingo, eyafumana elinye ibhaso ngokuSebenza kunye neZiko leNkcazo.

Iindawo eziThabatha inxaxheba kwiZifundo eziKhokelayo (i-LAPS)

Amashumi amathathu anesibini amaziko emfundo aseMelika anikwe isibonelelo seNdawo yokuThatha iNxaxheba yeZifundo (i-LAPS), ongumthombo wenkxaso mali eyenzelwe ngokukodwa i-NCTN. Iindawo ngamaziko ophando kwezemfundo kunye neenkqubo zoqeqesho lobudlelane, kwaye uninzi lwababoneleli ngamaziko eCancer-Cancer Cancer. Ukufumana la mabhaso, iisayithi kuye kwafuneka zibonise ukukwazi kwabo ukubhalisa amanani aphezulu ezigulana kuvavanyo lwe-NCTN, kunye nobunkokeli benzululwazi kuyilo kunye nokuziphatha kwezilingo zeklinikhi.

Izibonelelo ezingama-32 zeLAPS zezi:

Kwimeko yeDyunivesithi yaseVestern Reserve-Kwimeko yeZiko loMhlaza eliBanzi iDana Farber / iZiko loMhlaza laseHarvard

IZiko loMhlaza leDuke kwiziko lezonyango laseDuke

IYunivesithi yaseEmory-iZiko loMhlaza eWinship

Iziko loPhando ngomhlaza kaFred Hutchinson

IYunivesithi yaseJohn Hopkins-iSidney Kimmel iZiko loMhlaza eliBanzi

IZiko leMhlaza lekliniki yaseMayo

KwiKholeji yezonyango yaseWisconsin

IZiko leCancer Sloan Kettering Centre

IZiko loMhlaza weNorris Cotton kwiZiko lonyango laseDartmouth Hitchcock

IYunivesithi yaseNyakatho-ntshona-iRobert H. Lurie iZiko loMhlaza eliBanzi

Iziko leYunivesithi yaseOhio State

IZiko loMhlaza laseRoswell Park

ISidney Kimmel Centre yeCancer kwiJefferson Health

IYunivesithi yaseAlabama eBirmingham

IYunivesithi yaseCalifornia Davis iZiko loMhlaza eliBanzi

IYunivesithi yaseChicago iZiko loMhlaza eliBanzi

IYunivesithi yaseColorado Cancer Centre

IYunivesithi yaseMichigan Centre yeCancer Comprehensive

IYunivesithi yaseNorth Carolina Lineberger iZiko loMhlaza eliBanzi

IYunivesithi yase-Oklahoma-iStephenson Cancer Centre

IYunivesithi yasePittsburgh Cancer Institute

IYunivesithi yaseRochester Wilmot Cancer Institute

IYunivesithi yaseSouth California -Norris iZiko loMhlaza eliBanzi

IYunivesithi yaseTexas MD Iziko loMhlaza laseAnderson

IYunivesithi yaseTexas yeZiko lezoNyango laseNtshona-uHarold C. Simmons iZiko loMhlaza

IYunivesithi yase-Utah-Huntsman Cancer Institute

IYunivesithi yaseWisconsin iZiko loMhlaza leCarbone

IZiko lezoNyango laseVanderbilt leYunivesithi yaseVanderbilt

IYunivesithi yaseWashington eSt.Louis-Siteman Cancer Centre

IYunivesithi yaseWayne State Barbara Ann Karmanos Cancer Institute

IYunivesithi yaseYale-iZiko loMhlaza laseYale

Amanqanaba aphezulu obhaliso lwezigulana afuna inqanaba elizinzileyo lomsebenzi wolawulo lwedatha kwiminyaka eliqela, kwaye izibonelelo zeLAPS zixhasa abasebenzi bophando abafunekayo ukulawula lo mzamo. Imali ebonelelwe kwizibonelelo ze-LAPS ukugubungela lo msebenzi ukhulayo ngokufanelekileyo inyusa inqanaba lokubuyiselwa kwesigulana ngasinye kwiziza ezikhethiweyo.

Amabhaso e-LAPS abonelela ngenkxaso-mali kubunkokheli besayensi kunye nolawulo kwindawo leyo, njengoko abaphandi abaziintloko kwindawo leyo bebeka phambili izilingo zeklinikhi abathatha inxaxheba kuzo, kunye nokufundisa nokuqeqesha abasebenzi kwiindawo zophando lweklinikhi kunye nokuphuhlisa. Iindlela zokukhuthaza ukubhaliswa kwezigulana.

Izibhedlele zoLuntu kunye namaZiko oNyango

Uninzi lwabanye abaphandi kwizibhedlele zabahlali nakumaziko onyango banokuthatha inxaxheba kuvavanyo lwe-NCTN, nokuba bakwiindawo ezingakhange zifumane ibhaso le-LAPS. Ezi ndawo, kunye nenani leendawo zamazwe aphesheya, zifumana imbuyiselo yophando ngokuthe ngqo kwelinye lamaqela othungelwano ahambelana nawo okanye afumana amabhaso kwiNkqubo yoPhando lwe-Oncology yoLuntu ye-NCI (NCORP).

Ubulungu besiza kwiqela ngalinye le-NCTN lusekwe kwiikhrayitheriya ezithile kwiqela ngalinye. Iindawo eziqhuba iimvavanyo zeklinikhi zingangaphezulu kweqela elinye, kwaye nokuba lilungu kwiqela elinye kuvumela indawo ukuba ithathe inxaxheba kwizilingo ezikhokelwa lilo naliphi na iqela le-NCTN abafanele ukuba baphande ngalo. Ngenxa yoko, abaphandi abavela kwi-LAPS, i-NCORP, amanye amaziko emfundo, iinkqubo zoluntu, kunye namazwe aphesheya ahambelana namaqela eNethiwekhi banokubhalisa bonke abaguli kuvavanyo lwe-NCTN.

UkuJonga kunye neRadiation Oncology Core Group (IROC)

Ukunceda ukubeka esweni kunye nokuqinisekisa umgangatho kwizilingo ezibandakanya iindlela zokucinga ezintsha kunye / okanye unyango lwe-radiation, i-NCTN iseke iMifanekiso kunye neMitha yeRadiation Oncology Core (IROC) GroupExit Disclaimer encedisa onke amaqela e-NCTN asebenzisa ezi ndlela kwiimvavanyo zabo.

Amabhaso aDibeneyo okuGuqulela iSayensi (ITSA)

Icandelo lokugqibela le-NCTN ngaMabhaso aDibeneyo okuGuqulela iNzululwazi (ITSAs). Amaziko amahlanu emfundo afumene i-ITSA abandakanya amaqela ososayensi abaguqulelayo abasebenzisa ubuchwephesha bemfuza, iproteomic, kunye netekhnoloji yokucinga ukunceda ekuchongeni nasekufumaneni izinto ezinokubakho zokuphendula kunyango olunokuthi lubandakanywe ngamaqela othungelwano kuvavanyo lweklinikhi.

La mabhaso asetyenziselwa ukuphakamisa umsebenzi osele uqhubeka kwezi iilebhu zabaphandi, zihlala zixhaswa yinxalenye yezinye izibonelelo zeNCI, kulindeleke ukuba aba baphandi bancede amaqela enethiwekhi azise ukufunyanwa okutsha kwelabhoratri kuvavanyo lweklinikhi. Ezi lebhu zonke zisebenzisa itekhnoloji yokusika eyenza ukuba ukubonwa ngcono kwezidumbu kwaye kuncede ekuchongeni utshintsho kwibhayoloji yethumba ekuphenduleni kunyango olunokunceda ukucacisa ukuba uxhathiso lonyango lunokuphuhla njani.

Izibonelelo ze-ITSA zezi:

Isibhedlele saBantwana saseFiladelfiya Phuma kwi-Disclaimer

IYunivesithi yase-Emory-IZiko leCancer leWinship Exit Disclaimer

IZiko leCancer Sloan Kettering CentrePhuma kwi-Disclaimer

Iziko leYunivesithi yaseOhio State

IYunivesithi yaseNorth Carolina Lineberger iZiko loMhlaza eliPheleleyoPhuma kwi-Disclaimer

Iibhanki zeTissue Banks

Iqela ngalinye le-NCTN liqokelela kwaye ligcine izicwili kwizigulana kwizilingo ze-NCTN kuthungelwano oluhambelanayo lweebhanki zethishu. Iiprotokholi ezisemgangathweni ziphuhlisiwe ukuqinisekisa ukuba izicwili eziqokelelweyo zikumgangatho ophezulu kakhulu. Iirekhodi zekhompyuter zeesampulu ezigciniweyo zineenkcukacha ezibalulekileyo zeklinikhi, ezinje ngonyango olufunyenwe zizigulana ekuthathwe kuzo izicwili, impendulo yonyango, kunye nesiphumo sesigulana. Abathathi-nxaxheba kuvavanyo lwe-NCTN banokuvuma ekusebenziseni iisampulu zabo zethishu kwizifundo ezingaphaya kwetyala le-NCTN ababhalise kulo. Inkqubo yebhanki ye-NCTN yebhanki ibandakanya inkqubo esekwe kwiwebhu enokuthi isebenzise nawuphi na umphandi. Abaphandi, kubandakanya abo bangadibaniyo ne-NCTN,

IiKomiti zoLawulo lwezeNzululwazi

Amaqela e-NCTN acebisa iikhonsepthi zezilingo zeklinikhi ezintsha kwiiKomiti zeSifo se-NCI / kwiiKomiti zokuLawula. Ezi komiti ziququzelelwe yi-NCI ukuvavanya nokubeka phambili izilingo zeklinikhi kunye nokucebisa kwi-NCI abo banokuthi babe nefuthe eliphezulu kwizenzululwazi nakwiklinikhi. Ikomiti nganye ikhokelwa ngoosihlalo abangasebenziyo abangavumelekanga ukuba babambe izikhundla zobunkokeli kumaqela e-NCTN, nangona benokuba ngamalungu eqela. Intsalela yobulungu bekomiti inamalungu eqela le-NCTN akhethwe liqela ngalinye, ezinye iingcali zezifo ezingabandakanyekanga kwizikhundla zobunkokeli kumaqela, abameli be-SPORE exhaswa ngemali yi-NCI kunye ne-Consortia, i-biostatisticians, abagqwetha abaguli kunye neengcali zezifo ze-NCI.

Uhlahlo-lwabiwo mali lwe-NCTN

Uhlahlo-lwabiwo mali lwe-NCTN yi- $ 171 yezigidi, ihanjiswe kumacandelo ohlukeneyo enethiwekhi. Le nkqubo ibonelela ngobhaliso lonyaka malunga ne-17,000-20,000 yabathathi-nxaxheba kunyango lomhlaza kunye novavanyo lokucinga.

Ukusebenza ngokuNxibelelana

Amaqela e-NCTN ayakwazi ukunciphisa iindleko zokuqhuba izilingo ngokwabelana ngezixhobo. Le ndlela yokusebenzisana ivumela amalungu eqela elinye le-NCTN ukuba axhase izilingo ezikhokelwa ngamanye amaqela kwaye anike amalungu e-NCTN amandla okuqhuba ipotifoliyo yovavanyo olupheleleyo kumhlaza oqhelekileyo.

Kungenxa yokuba i-NCTN inamaqela abantu abadala kuphela e-US, ngokusebenza okumbalwa kunye namaZiko eSitatistiki afuna inkxaso yemali, kuye kwakho ukonga kwexabiso elipheleleyo. Onke amaqela asebenzisa inkqubo yolawulo lwedatha eqhelekileyo (iMedidata Rave) kunye nenkqubo ye-IT emanyanisiweyo yeebhanki zethishyu, eziguqula iindleko zokonga.

Inkxaso eyongezelelweyo

Ulingo lwezonyango zizinto ezintsonkothileyo ezifuna uninzi lwemibutho yenkxaso kunye nemithombo yenkxaso-mali. Inethiwekhi ibandakanya inani lezinye izinto ezingafakwanga kumabhaso e-NCTN kodwa ayimfuneko ekuphumezeni injongo ye-NCTN.

Inkxaso eyongezelelweyo ibandakanya:

• IiBhodi eziHlola iZiko eliPhakathi, icandelo elibalulekileyo lenkqubo yovavanyo lweklinikhi ye-NCI eyongeza isantya, ukusebenza ngokukuko kunye nokufana kuvavanyo lweenqobo ezisesikweni.

• ICandelo leNkxaso yovavanyo lweCancer (CTSU), ikhontrakthi exhaswa ngemali yi-NCI enika abaphandi bezonyango kunye nabasebenzi babo ukufikelela kwi-Intanethi kwi-NCTN kwaye ivumela abaphandi ukuba babhalise abaguli abatsha.

• Ibhanki yeethishu ezinikeleyo kwiqela ngalinye lenethiwekhi exhaswa ngemali ngendlela eyahlukileyo yokunikezelwa kweNCI.

• I-Biomarker, Imaging, kunye noMgangatho weNkqubo yeNkxaso-mali yeziFundo zoBomi (i-BIQSFP), umsinga wenkxaso mali owahlukileyo wezilingo ze-NCTN ezixhasa izifundo zesayensi ezihambelana nolingo lweqela. Amaqela e-NCTN akhuphisana ngemali ebekelwe ngokukodwa le njongo minyaka le. Ukufumaneka kwemali ezinikeleyo kuququzelela ulungelelwaniso, njengoko iimvavanyo zeklinikhi kufuneka zihlangabezane nemihla ebekiweyo.

• Ukongeza, malunga nekota enye yesongezelelo sesigulana kuvavanyo lonyango lwe-NCTN ihlawulwa yinkqubo ye-NCORP. Izibhedlele zoluntu kunye namaziko onyango athabatha inxaxheba kwinkqubo ye-NCORP abuyiselwa ekufumaneni abaguli kwizilingo zonyango lwe-NCTN ngamabhaso abo e-NCORP, hayi ngebhaso le-NCTN Group Operations.

Okokugqibela, ukongeza kwezi nkcitho zininzi zonyaka, i-NCI ikwaxhasa i-NCTN ngokuhlawulela eminye imisebenzi emininzi yolingo lweklinikhi, ngaloo ndlela kuncitshiswa iindleko ezihanjiswa ngamaqela eNethiwekhi:

• I-NCI ihlawulela iilayisensi kunye neefizi zokubamba zekhompyuter, inkqubo yolawulo lwedatha eqhelekileyo, ebizwa ngokuba yiMedidata Rave, esetyenziswa ngawo onke amaqela eNCTN.

• I-NCI yongamela inkqubo yophicotho-zincwadi lukazwelonke kwizilingo ze-NCTN.

• I-NCI ilawula ukuphandwa kwezicelo zeMithi eNtsha kuLawulo lokuTya kunye neDrug kunye nokusasazwa kwala machiza kwizilingo ezininzi ze-NCTN.

Ukusebenzisana phakathi kwamaqela kujongwa njengokubalulekileyo kwimpumelelo kuwo onke amanqanaba ombutho kwaye ngoku kuvuzwa ngokukodwa ngexesha lokuphononongwa kwesibonelelo. Ukusebenza kakuhle kukwagxininisiwe, kwaye amaxesha anyanzelekileyo ngoku akhoyo kuphuhliso lomgaqo. Nangona olu tshintsho lujongwa njengolubalulekileyo kwimpilo yenkqubo kawonkewonke, zikwaye zafika ngexesha elifanelekileyo, kuba utshintsho olunomdla kwisayensi ye-oncologic lubonelela ngeendlela ezintsha zokuqhubela phambili ngokukhawuleza, ngakumbi kuphuhliso lonyango olutsha.