About-cancer/treatment/clinical-trials/thymoma-thymic-carcinoma
Uvavanyo lwezonyango ukunyanga i-Thymoma kunye ne-Thymic Carcinoma
Iimvavanyo 1-12 ze-12
I-Carboplatin kunye nePaclitaxel kunye okanye ngaphandle kweRamucirumab ekunyangeni abaguli abane-Cancer Advanced, Recurrent, okanye Metastatic Thymic Cancer engenakususwa ngotyando
Olu phononongo lwesigaba sesi-2 solingo esingahleliwe sisebenza njani ukuba i-carboplatin kunye ne-paclitaxel kunye okanye ngaphandle kwe-ramucirumab isebenza njani ekunyangeni abaguli abanomhlaza we-thymic osasazeke kwizicubu ezikufutshane okanye kwii-lymph node (ekuphambili apha), ibuyile (iphindaphindekile), isasazekile kwezinye iindawo kwindawo body (metastatic) okanye ayinakususwa ngotyando. Iziyobisi ezisetyenziswa kwi-chemotherapy, ezinje nge-carboplatin kunye ne-paclitaxel, zisebenza ngeendlela ezahlukeneyo ukunqanda ukukhula kweeseli zethumba, nokuba kungokubulala iiseli, ngokuzinqanda ekwahluleni, okanye ngokuzinqanda zisasazeke. Ama-antibodies e-Monoclonal, anjenge ramucirumab, anokuphazamisa amandla eeseli zethumba ukukhula kunye nokusasazeka. Akukaziwa ukuba ukunika i-carboplatin kunye ne-paclitaxel kunye okanye ngaphandle kwe-ramucirumab kuya kusebenza ngcono ekunyangeni abaguli abanomhlaza we-thymic.
Indawo: Iindawo ezingama-254
Isifundo seXmAb®20717 kwiziFundo ngeeThumba eziQinisekileyo eziQhelekileyo
Esi sisiGaba 1, idosi ezininzi, ukunyuka kwesifundo sokunyuka kwedosi ukuchaza i-MTD / RD kunye nerejimeni yeXmAb20717, ukuchaza ukhuseleko kunye nokunyamezelana, ukuvavanya i-PK kunye ne-immunogenicity, kunye nokuvavanya kwangaphambili umsebenzi wokuchasana nethumba weXmAb20717 kwizifundo ezikhethiweyo amathumba aqinileyo aqhubele phambili.
Indawo: Iindawo ezili-15
I-Nivolumab kunye neVorolanib ekunyangeni abaguli abaneCancer Cancer engeyiyo encinci kunye ne-Refractory Thoracic Tumors.
Esi sigaba sokulinga se-I / II sophando lweziphumo ebezingalindelekanga kunye nethamo elifanelekileyo le-vorolanib xa linikezelwa ngokudibeneyo ne-nivolumab ekunyangeni abaguli abanomhlaza wamaphaphu ongaqhelekanga kunye ne-thoracic tumors ezingaphenduliyo kunyango (elichasayo). I-Immunotherapy ene-monoclonal antibodies, efana ne-nivolumab, inokunceda amajoni omzimba ahlasele umhlaza, kwaye inokuphazamisa amandla eeseli zethumba ukukhula kunye nokusasazeka. IVorolanib inokumisa ukukhula kweeseli zesisu ngokuthintela ezinye ii-enzymes ezifunekayo ekukhuleni kweseli. Ukunika i-nivolumab kunye ne-vorolanib kunokusebenza ngcono ekunyangeni abaguli abanesifo somhlaza wamaphaphu esincinci kunye nesifo se-thoracic tumors.
Indawo: Iindawo ezi-7
Ukufundwa kwe-SO-C101 kunye ne-SO-C101 ngokudityaniswa nePembro kwizigulana zabantu abadala ezinamaThumba aQinisekileyo / iMetastatic Solid
Isigaba se-1 / 1b esivulekileyo esivulekileyo sokuvavanya ukhuseleko kunye nokusebenza kwangaphambili kwe-SO-C101 njenge-monotherapy kunye nokudibanisa ne-pembrolizumab kwizigulana ezinamathumba akhethiweyo aphezulu / e-metastatic solid
Indawo: Indawo ezi- 2
Uhlalutyo olukhawulezileyo kunye noVavanyo lweempendulo zokudityaniswa kweearhente ezichasene neplastic kwiRare Tumors (RARE CANCER) Trial: RARE 1 Nilotinib kunye nePaclitaxel
Imvelaphi: Abantu abanomhlaza onqabileyo bahlala bekhetha unyango olunomda. Ibhayoloji yomhlaza onqabileyo ayiqondwa kakuhle. Abaphandi bafuna ukufumana unyango olungcono kule mihlaza. Bafuna ukuvavanya amachiza ama-2 athi, athathwe ngokwahlukeneyo, ancede abantu abanomhlaza ongaqhelekanga. Bafuna ukubona ukuba la machiza xa edibene angenza umhlaza onqabileyo unciphe okanye uyeke ukukhula. Injongo: Ukufunda ukuba i-nilotinib kunye ne-paclitaxel ziya kunceda abantu abanomhlaza onqabileyo. Ukufaneleka: Abantu abaneminyaka eli-18 nangaphezulu abanesifo somhlaza esinqabileyo, esiqhubele phambili emva kokufumana unyango oluqhelekileyo, okanye ekungekho lonyango lusebenzayo. Uyilo: Abathathi-nxaxheba baya kuvavanywa ngembali yezonyango kunye novavanyo lomzimba. Baza kuvavanywa igazi nomchamo. Baya kuba novavanyo lokukhulelwa xa kufuneka njalo. Baya kuba ne-electrocardiogram ukujonga iintliziyo zabo. Baza kuba nemifanekiso yokulinganisa ukulinganisa amathumba abo. Abathathi-nxaxheba baya kuphinda uvavanyo lokuvavanywa ngexesha lofundo. Abathathi-nxaxheba baya kufumana i-nilotinib kunye ne-paclitaxel. Amachiza anikezelwa kwimijikelo yeentsuku ezingama-28. I-Nilotinib yi-capsule ethathwe ngomlomo kabini ngemini. I-Paclitaxel iya kunikwa ngaphakathi ngaphakathi ngomgca wendlela okanye kumda osembindini kube kanye ngeveki kwiiveki zokuqala ezi-3 kumjikelo ngamnye. Abathathi-nxaxheba baya kugcina idayari yamayeza. Baya kulandelela xa bethatha amayeza ophando kunye naziphi na iziphumo ebezingalindelekanga abanokuba nazo. Abathathi-nxaxheba banakho ukuba ne-tumor biopsies. Abathathi-nxaxheba banokuhlala kuphononongo de isifo sibe sibi kakhulu okanye babe neziphumo ebezingalindelekanga ezinganyamezelekiyo. Abathathi-nxaxheba baya kuba nefowuni yokulandelela malunga neentsuku ezingama-30 emva kokuthatha idosi yokugqibela yamachiza okufunda. Abathathi-nxaxheba baya kufumana i-nilotinib kunye ne-paclitaxel. Amachiza anikezelwa kwimijikelo yeentsuku ezingama-28. I-Nilotinib yi-capsule ethathwe ngomlomo kabini ngemini. I-Paclitaxel iya kunikwa ngaphakathi ngaphakathi ngomgca wendlela okanye kumda osembindini kube kanye ngeveki kwiiveki zokuqala ezi-3 kumjikelo ngamnye. Abathathi-nxaxheba baya kugcina idayari yamayeza. Baya kulandelela xa bethatha amayeza ophando kunye naziphi na iziphumo ebezingalindelekanga abanokuba nazo. Abathathi-nxaxheba banakho ukuba ne-tumor biopsies. Abathathi-nxaxheba banokuhlala kuphononongo de isifo sibe sibi kakhulu okanye babe neziphumo ebezingalindelekanga ezinganyamezelekiyo. Abathathi-nxaxheba baya kuba nefowuni yokulandelela malunga neentsuku ezingama-30 emva kokuthatha idosi yokugqibela yamachiza okufunda. Abathathi-nxaxheba baya kufumana i-nilotinib kunye ne-paclitaxel. Amachiza anikezelwa kwimijikelo yeentsuku ezingama-28. I-Nilotinib yi-capsule ethathwe ngomlomo kabini ngemini. I-Paclitaxel iya kunikwa ngaphakathi ngaphakathi ngomgca wendlela okanye kumda osembindini kube kanye ngeveki kwiiveki zokuqala ezi-3 kumjikelo ngamnye. Abathathi-nxaxheba baya kugcina idayari yamayeza. Baya kulandelela xa bethatha amayeza ophando kunye naziphi na iziphumo ebezingalindelekanga abanokuba nazo. Abathathi-nxaxheba banakho ukuba ne-tumor biopsies. Abathathi-nxaxheba banokuhlala kuphononongo de isifo sibe sibi kakhulu okanye babe neziphumo ebezingalindelekanga ezinganyamezelekiyo. Abathathi-nxaxheba baya kuba nefowuni yokulandelela malunga neentsuku ezingama-30 emva kokuthatha idosi yokugqibela yamachiza okufunda. I-Paclitaxel iya kunikwa ngaphakathi ngaphakathi ngomgca wendlela okanye kumda osembindini kube kanye ngeveki kwiiveki zokuqala ezi-3 kumjikelo ngamnye. Abathathi-nxaxheba baya kugcina idayari yamayeza. Baya kulandelela xa bethatha amayeza ophando kunye naziphi na iziphumo ebezingalindelekanga abanokuba nazo. Abathathi-nxaxheba banakho ukuba ne-tumor biopsies. Abathathi-nxaxheba banokuhlala kuphononongo de isifo sibe sibi kakhulu okanye babe neziphumo ebezingalindelekanga ezinganyamezelekiyo. Abathathi-nxaxheba baya kuba nefowuni yokulandelela malunga neentsuku ezingama-30 emva kokuthatha idosi yokugqibela yamachiza okufunda. I-Paclitaxel iya kunikwa ngaphakathi ngaphakathi ngomgca wendlela okanye kumda osembindini kube kanye ngeveki kwiiveki zokuqala ezi-3 kumjikelo ngamnye. Abathathi-nxaxheba baya kugcina idayari yamayeza. Baya kulandelela xa bethatha amayeza ophando kunye naziphi na iziphumo ebezingalindelekanga abanokuba nazo. Abathathi-nxaxheba banakho ukuba ne-tumor biopsies. Abathathi-nxaxheba banokuhlala kuphononongo de isifo sibe sibi kakhulu okanye babe neziphumo ebezingalindelekanga ezinganyamezelekiyo. Abathathi-nxaxheba baya kuba nefowuni yokulandelela malunga neentsuku ezingama-30 emva kokuthatha idosi yokugqibela yamachiza okufunda.
Indawo: Amaziko kaZwelonke eKliniki, eBethesda, eMaldin
I-Pembrolizumab kunye ne-Sunitinib Malate ekunyangeni abaThathi-nxaxheba ngeMetastatic Refractory okanye i-Thymic Cancer engafumanekiyo.
Isigaba sesibini solingo sifundo ukuba isebenza njani kakuhle i-pembrolizumab kunye ne-sunitinib malate ekunyangeni abathathi-nxaxheba abanomhlaza we-thymic osasazeke kwezinye iindawo emzimbeni okanye ongenakususwa ngotyando kwaye awuphenduli kunyango. Ama-antibodies e-Monoclonal, njenge-pembrolizumab, anokuphazamisa amandla eeseli zethumba ukukhula kunye nokusasazeka. I-Sunitinib malate inokumisa ukukhula kweeseli zesisu ngokuthintela ezinye ii-enzymes ezifunekayo ekukhuleni kweseli. Ukunika i-pembrolizumab kunye ne-sunitinib malate kunokusebenza ngcono ekunyangeni umhlaza we-thymic.
Indawo: IYunivesithi yaseOhio State University iComprehensive Cancer Centre, eColumbus, eOhio
IPembrolizumab ekuNyangeni abaThathi-nxaxheba nge-Thymoma engafumanekiyo okanye umhlaza weThymic
Eli nqanaba ndilingwa kuvavanyo lweziphumo kunye nedosi efanelekileyo ye-pembrolizumab ekunyangeni abathathi-nxaxheba nge-thymoma okanye umhlaza we-thymic ongenakususwa ngotyando. I-Immunotherapy ene-monoclonal antibodies, enjenge-pembrolizumab, inokunceda amajoni omzimba ahlasele umhlaza, kwaye inokuphazamisa ukubanakho kweeseli zethumba ukukhula kunye nokusasazeka.
Indawo: Iziko loMhlaza le-And Anderson, eHouston, eTexas
I-Selinexor ekunyangeni abathathi-nxaxheba nge-Advanced Thymic Epithelial Tumor
Isigaba sesibini sokuvavanywa kwesilingo sokuba isebenza njani i-selinexor ekunyangeni abathathi-nxaxheba nge-thymic epithelial tumor ethe yasasazeka kwezinye iindawo emzimbeni. I-Selinexor inokumisa ukukhula kweeseli zesisu ngokuthintela ezinye zeeproteni ezifunekayo ekukhuleni kweseli.
Indawo: Indawo ezi- 2
IBintrafusp Alfa (M7824) kwizifundo ezineThymoma kunye neThymic Carcinoma
Imvelaphi: I-Thymoma kunye ne-thymic carcinoma zizifo ze-thymus. I-Platinum-based based chemotherapy yonyango oluqhelekileyo lwezi zifo. Kodwa kwiimeko ezininzi, esi sifo siyabuya emva konyango. Abaphandi bafuna ukubona ukuba ichiza elitsha linganceda. Injongo: Ukujonga ukuba i-bintrafusp alfa (M7824) lunyango olusebenzayo lwe-thymoma kunye ne-thymic carcinoma. Ukufaneleka: Abantu abaneminyaka eyi-18 nangaphezulu abanesifo se-thymoma okanye somhlaza we-thymic kwaye isifo sabo sibuyele okanye saqhubela phambili emva konyango ubuncinci ngesicwangciso sonyango esine-platinamu, okanye balile uyilo oluqhelekileyo loyilo: Abathathi-nxaxheba baya kuvavanywa phantsi komgaqo ohlukileyo. Imbali yabo yezonyango, amayeza kunye nonyango iya kuphononongwa. Baya kuba ne-tumor biopsy ukuba abanayo isampuli. Abathathi-nxaxheba baya kufumana iyeza lokufunda kube kanye kwiiveki ezi-2 njengokufakwa ngaphakathi. Ukulungiselela le nto, ityhubhu encinci yeplastiki ifakwa kumthambo wengalo. Ngexesha lokufunda, abathathi-nxaxheba baya kwenziwa oku kulandelayo: Uphononongo lwamayeza Uvavanyo lomzimba Ukuphononongwa kweempawu zabo kunye nokukwazi kwabo ukwenza imisebenzi yabo yesiqhelo Uvavanyo lwegazi kunye nomchamo Uthambo lokuskena kwemisipha (kusetyenziswa iMRI) Uvavanyo lwethumba (kusetyenziswa iMRI okanye i-CT) Uvavanyo lwentliziyo kunye nemiphunga Uvavanyo lwe-thyroid gland uvavanyo lolusu. Abathathi-nxaxheba banokuba ne-tumor biopsies. Ezinye zegazi kunye neesampulu ze-biopsy ziya kusetyenziselwa ukuvavanywa kofuzo. Abathathi-nxaxheba banokuthatha eli chiza lokufunda de isifo sibe sibi okanye bangakwazi ukunyamezela unyango. Abathathi-nxaxheba baya kuba notyelelo olulandelelanayo kwiiveki ezi-2 ne-6 emva kokuyeka unyango. Emva koko baya kuba notyelelo lwexesha elide rhoqo emva kweenyanga ezi-3. Oku kunokubandakanya iskena sokucinga. Ukutyelelwa kunokwenziwa ngefowuni, ngezikena (ukuba ziyafuneka) ezenziwa kwiofisi kagqirha wabo. Indawo:
Abexinostat kunye nePembrolizumab ekuNyangeni abaguli abane-MSI-High ekuhlaleni ePhakamileyo okanye kwiMetastatic Solors Tumors
Eli nqanaba ndilingwa kuvavanyo lwethamo kunye neziphumo ebezingalindelekanga ze-abexinostat kunye nokuba isebenza njani ngokunikezelwa kunye ne-pembrolizumab ekunyangeni abaguli abane-microsatellite instability (MSI) amathumba aqinileyo athe asasazeka kwizicwili ezikufutshane okanye kwiindawo ezinendawo ekuhlalwa kuyo (kwiindawo eziphambili). emzimbeni (metastatic). I-Abexinostat inokumisa ukukhula kweeseli zesisu ngokuthintela ezinye ii-enzymes ezifunekayo ekukhuleni kweseli. I-Immunotherapy ene-monoclonal antibodies, enjenge-pembrolizumab, inokunceda amajoni omzimba ahlasele umhlaza, kwaye inokuphazamisa ukubanakho kweeseli zethumba ukukhula kunye nokusasazeka. Ukunika i-abexinostat kunye ne-pembrolizumab kunokusebenza ngcono ekunyangeni abaguli abanamathumba aqinileyo.
Indawo: IZiko lezoNyango le-UCSF-iNtaba yeZiyon, iSan Francisco, California
I-Oral TrkA Inhibitor VMD-928 yokuNyanga amaThumba aQhelekileyo aBadala aQinisekileyo okanye iLymphoma
Eli liziko elinolwazi oluninzi, iilebhile ezivulekileyo, isifundo seSigaba 1 se-VMD-928 elawulwa ngomlomo kwizifundo zabantu abadala ezinezilonda eziqinileyo okanye i-lymphoma eqhubele phambili okanye engaphenduliyo kunyango olukhoyo kwaye kungekho nyango lunyango lukhoyo.
Indawo: IsiXeko seThemba iZiko loMhlaza eliBanzi, eDuarte, eCalifornia
Isifundo soPhando lokuKhangela uPhando loKhuseleko kunye noMsebenzi weKlinikhi weAvelumab (MSB0010718C) e-Thymoma kunye ne-Thymic Carcinoma Emva kokuqhubela phambili kwi-Platinum-based Chemotherapy
Imvelaphi: I-Thymoma kunye ne-thymic carcinoma zii-cancer ezivela kwi-thymus gland. Unyango olusekwe kwiPlatinamu lunyango oluqhelekileyo kubo. Kodwa ngokungaqhelekanga, isifo siyabuya kwaye abantu bafuna unyango olungaphezulu ukugcina umhlaza ungakhuli. Iyeza i-Avelumab inokunceda amajoni omzimba alwe nomhlaza. Injongo: Ukuvavanya ukuba i-avelumab ikhuselekile kwaye iyanyamezeleka, kwaye iyasebenza ekunyangeni i-thymoma ebuyela umva okanye ephikisayo kunye ne-thymic carcinoma. Ukufaneleka: Abantu abaneminyaka eli-18 nangaphezulu abane-thymoma okanye i-thymic carcinoma ebuyileyo okanye eqhubekileyo emva kokuba i-platinum iqulethe i-chemotherapy Uyilo: Abathathi-nxaxheba baya kuvavanywa nge: -Igazi, umchamo, kunye novavanyo lwentliziyo -Skena: Balala kumatshini othatha imifanekiso umzimba. - Uvavanyo lomzimba - Imbali yezonyango - iBiopsy: inaliti isusa iqhekeza lethumba. Iisampulu zinokuvela kwinkqubo yangaphambili, nangona kunqweneleka ukwenza i-biopsy entsha. Abathathi-nxaxheba baya kuba nonyango kwimijikelezo yeeveki ezi-2. Ziya kuqhubeka kude kube ziziphumo ebezingalindelekanga ezinganyamezelekiyo okanye isifo siya sisiba mandundu. Ukutyelelwa ngala maxesha alandelayo kuyafuneka ngokweprotocol. Izigulana eziphendula kunyango okanye ezinokuzinza emva kweenyanga ezili-12 zonyango zinokufumana idosi yokunyuka kwethamo ukuze iqhubeke kunyango. -Zonke iiveki ezi-2: Abathathi-nxaxheba baya kufumana i-avelumab ngokufakwa ngaphakathi emthanjeni (IV). Baza kufumana i-diphenhydramine (benadryl) kunye ne-acetaminophen (tylenol) ngomlomo okanye nge-IV ngaphambi kokufumana i-avelumab ukunciphisa amathuba okuphucula impendulo kwi-avelumab. Baza kuba negazi, umchamo, kunye novavanyo lwentliziyo rhoqo. -Imijikelezo yesi-4 neye-7, emva koko rhoqo kwiiveki ezi-6: Kuya kwenziwa iscans ukukhangela ukuncipha okanye ukukhula kwethumba. Umjikelo 4: Abathathi-nxaxheba baya kunikwa ithuba lokuya kuvavanyo. -Iiveki ezi-2 ukuya kwezi-4 emva kokuyeka unyango: Kuya kwenziwa igazi, umchamo, kunye novavanyo lwentliziyo. Abathathi-nxaxheba banokuvavanywa. - iiveki ezili-10 emva kokuyeka unyango: Igazi, umchamo kunye nokuvavanywa kwentliziyo. - Malunga neenyanga ezi-6 emva kokuyeka unyango, emva koko kwiinyanga ezi-3: Abathathi-nxaxheba baya kuba nezikena kwaye bangavumela uvavanyo lwemfuzo kwiisampulu zegazi kunye nezicubu.
Indawo: Amaziko kaZwelonke eKliniki, eBethesda, eMaldin
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