Malunga-nomhlaza / unyango / ulingo lweklinikhi / isifo / i-kaposi-sarcoma / unyango

Unyango lwezilingo zovavanyo lweKaposi Sarcoma

Uvavanyo lwezonyango zizifundo zophando ezibandakanya abantu. Uvavanyo lweklinikhi kolu luhlu lonyango lwe-Kaposi sarcoma. Zonke izilingo ezikuluhlu ziyaxhaswa yi-NCI.

Ulwazi olusisiseko lwe-NCI malunga nolingo lweklinikhi luchaza iintlobo kunye nezigaba zovavanyo kunye nendlela ezenziwa ngayo. Uvavanyo lwezonyango lujonga iindlela ezintsha zokuthintela, ukufumanisa, okanye ukunyanga izifo. Unokufuna ukucinga ngokuthatha inxaxheba kuvavanyo lweklinikhi. Thetha nogqirha wakho ngoncedo ekunqumeni ukuba ikulungele na.

Iimvavanyo 1-7 ze-7

I-Nivolumab kunye ne-Ipilimumab ekunyangeni abaguli abane-HIV Amanyaniswa abuye abuye okanye abonakalise i-Classical Hodgkin Lymphoma okanye ii-Tumors eziQinisekileyo eziMetastatic okanye azinakususwa ngotyando

Eli nqanaba ndilingwa kuvavanyo lweziphumo ebezingalindelekanga kunye nethamo elifanelekileyo le-nivolumab xa inikwa i-ipilimumab ekunyangeni abaguli abane-virus ye-immunodeficiency virus (HIV) ehambelana ne-Hodgkin lymphoma ehambelana nokubuyela emva kwexesha lokuphucula okanye elingaphenduliyo kunyango, okanye amathumba aqinileyo sele zisasazekile kwezinye iindawo emzimbeni okanye azinakususwa ngotyando. I-Immunotherapy ene-monoclonal antibodies, njenge-ipilimumab kunye ne-nivolumab, inokunceda amajoni omzimba ahlasele umhlaza, kwaye inokuphazamisa ukubanakho kweeseli zethumba ukukhula kunye nokusasazeka. I-Ipilimumab yintsholongwane esebenza ngokuchasene nemolekyuli ebizwa ngokuba yi-cytotoxic T-lymphocyte antigen 4 (CTLA-4). I-CTLA-4 ilawula icandelo lamajoni akho omzimba ngokuwavala. I-Nivolumab luhlobo lwe-antibody ekhethekileyo yokufa kweseli okucwangcisiweyo kwabantu 1 (PD-1), iprotheni ejongene nokutshatyalaliswa kweeseli zomzimba. Ukunika i-ipilimumab nge-nivolumab kunokusebenza ngcono ekunyangeni abaguli abane-HIV enxulumene ne-Hodgkin lymphoma okanye i-tumors eqinileyo xa kuthelekiswa ne-ipilimumab ene-nivolumab yodwa.

Indawo: Iindawo ezingama-28

UNelfinavir Mesylate ekuNyangeni abaguli abaneKaposi Sarcoma

Isigaba sesibini sokulinga silinganisa ukuba i-nelfinavir mesylate isebenza njani ekunyangeni abaguli abane-Kaposi sarcoma. I-Nelfinavir mesylate inokumisa ukukhula kweeseli zesisu ngokuthintela ezinye ii-enzymes ezifunekayo ekukhuleni kweseli.

Indawo: Iindawo ezili-11

I-EpB4-HSA ekunyangeni abaguli abaneKaposi Sarcoma

Esi sigaba sesibini sophando lwe-EphB4-HSA protein fusion (sEphB4-HSA) ekunyangeni abaguli abane-Kaposi sarcoma. Iprothini ye-fB4-HSA ye-Recombinant EphB4-HSA inokuthintela ukukhula kwemithambo yegazi ebonelela ngegazi kumhlaza, kwaye inokuthintela iiseli zomhlaza ekukhuleni.

Indawo: Iindawo ezili-10

I-Pembrolizumab ekunyangeni abaguli abane-HIV kunye nokubuyela umva, ukuphikisa, okanye ukuhambisa ii-Neoplasms ezimbi

Eli nqanaba lokuvavanywa kuvavanyo lweziphumo ebezingalindelekanga zepembrolizumab ekunyangeni abaguli abanentsholongwane ye-immunodeficiency virus (HIV) kunye neoplasms ezinobungozi eziye zabuya (zabuyela umva), aziphenduli kunyango (ezinganyangekiyo), okanye zisasaze kwindawo enkulu emzimbeni (isasaziwe). Ama-antibodies e-Monoclonal, njenge-pembrolizumab, anokuthintela ukukhula kwethumba okanye ukukhula komhlaza ngeendlela ezahlukeneyo ngokujolisa kwiiseli ezithile. Inokunceda amajoni omzimba abulale iiseli zomhlaza.

Indawo: Iindawo ezili-10

I-Nivolumab ye-Intra-lesional ekunyangeni abaguli abane-cutaneous Kaposi Sarcoma

Eli nqanaba ndilingwa kuvavanyo lweziphumo ebezingalindelekanga ze-nivolumab ejojowe ngqo kwisilonda kunye nokubona ukuba isebenza njani ekunyangeni abaguli abane-Kaposi sarcoma. I-Immunotherapy ene-monoclonal antibodies, efana ne-nivolumab, inokunceda amajoni omzimba ahlasele umhlaza, kwaye inokuphazamisa amandla eeseli zethumba ukukhula kunye nokusasazeka.

Indawo: Indawo ezi- 2

Imbali ye-KSHV Inflammatory Cytokine Syndrome (KICS)

Imvelaphi: -I-KSHV ye-cytokine syndrome evuthayo (i-KICS) sisifo esandula ukubonwa esibangelwa yi-Kaposi sarcoma enxulumene ne-herpesvirus (KSHV). Le ntsholongwane inokubangela umhlaza. Abantu abane-KICS banokuba neempawu ezinzima. Babandakanya umkhuhlane, ukunciphisa umzimba, kunye nolwelo emilenzeni okanye esiswini. Abantu abane-KICS banokuba semngciphekweni wokufumana ezinye iicancer ezinxulumene ne-KSHV. Ezi zomhlaza zibandakanya iKaposi sarcoma kunye ne-lymphoma. Ngenxa yokuba i-KICS sisifo esisandula ukufunyanwa, ulwazi oluthe kratya luyafuneka malunga nokuba sisebenza njani na kwaye yintoni esinokuyenza ukusinyanga. Iinjongo: -Ukuqokelela ulwazi ngemfuza nangonyango kubantu abane-cytokine syndrome ye-KSHV. Ukufaneleka: - Abantu ubuncinci ubuneminyaka eli-18 ubudala abane-Kaposi sarcoma herpes virus kunye neempawu ezifana nezo zibangelwa yi-KICS. Uyilo: -Abathathi-nxaxheba baya kuba notyelelo rhoqo lokufunda. Ishedyuli iya kugqitywa ngabaphandi bophando. - Abathathi-nxaxheba baya kubonelela ngembali yezonyango epheleleyo kwaye baya kuba novavanyo olupheleleyo lomzimba. Iisampulu zegazi kunye nomchamo ziya kuqokelelwa nazo. -Abantu abane-KICS efuna unyango banokufumana unyango olutsha. Olu nyango lunokubandakanya amachiza antiviral kunye namachiza e-chemotherapy, kuxhomekeka kubume besifo. - Abathathi-nxaxheba baya kuba nezifundo zokucinga, ezinje ngesifuba i-x-reyi kunye nekhompyuter ye-tomography scans, yokufunda amathumba. Umongo wethambo kunye ne-lymph node biopsies zinokwenziwa ukuqokelela iisampulu zethishu zokufunda. - Abathathi-nxaxheba abaneKaposi sarcoma baya kuba nefoto ezithathiweyo zezilonda zabo. -Abantu abane-KICS efuna unyango banokufumana unyango olutsha. Olu nyango lunokubandakanya amachiza antiviral kunye namayeza e-chemotherapy, kuxhomekeka kubume besifo. - Abathathi-nxaxheba baya kuba nezifundo zokucinga, ezinje ngesifuba i-x-reyi kunye nekhompyuter ye-tomography scans, yokufunda amathumba. Umongo wethambo kunye ne-lymph node biopsies zinokwenziwa ukuqokelela iisampulu zethishu zokufunda. - Abathathi-nxaxheba abaneKaposi sarcoma baya kuba nefoto ezithathiweyo zezilonda zabo. -Abantu abane-KICS efuna unyango banokufumana unyango olutsha. Olu nyango lunokubandakanya amachiza antiviral kunye namayeza e-chemotherapy, kuxhomekeka kubume besifo. - Abathathi-nxaxheba baya kuba nezifundo zokucinga, ezinje ngesifuba i-x-reyi kunye nekhompyuter ye-tomography scans, yokufunda amathumba. Umongo wethambo kunye ne-lymph node biopsies zinokwenziwa ukuqokelela iisampulu zethishu zokufunda. - Abathathi-nxaxheba abaneKaposi sarcoma baya kuba nefoto ezithathiweyo zezilonda zabo. Umongo wethambo kunye ne-lymph node biopsies zinokwenziwa ukuqokelela iisampulu zethishu zokufunda. - Abathathi-nxaxheba abaneKaposi sarcoma baya kuba nefoto ezithathiweyo zezilonda zabo. Umongo wethambo kunye ne-lymph node biopsies zinokwenziwa ukuqokelela iisampulu zethishu zokufunda. - Abathathi-nxaxheba abaneKaposi sarcoma baya kuba nefoto ezithathiweyo zezilonda zabo.

Indawo: Indawo ezi- 2

I-Pomalidomide ngokudibanisa neLiposomal Doxorubicin kuBantu abaPhucukileyo okanye abaPhikisayo eKaposi Sarcoma

Imvelaphi: I-Kaposi sarcoma (KS) ngumhlaza oqhele ukubonwa kubantu abane-HIV. Yenza izilonda. Oku kuhlala kwesikhumba kodwa ngamanye amaxesha kwii-lymph node, imiphunga kunye neendlela zesisu. Abaphandi bacinga ukuba indibaniselwano yamachiza inokunceda ukunyanga i-KS. Injongo: Ukuvavanya indibaniselwano yamachiza alwa nomhlaza pomalidomide (CC-4047) kunye ne-liposomal doxorubicin (Doxil) kubantu abane-KS. Ukufaneleka: Abantu abaneminyaka eli-18 nangaphezulu nge-KS Design: Abathathi-nxaxheba baya kujongwa kunye: Imbali yezonyango Amaphepha emibuzo Uvavanyo lomzimba Igazi, umchamo, kunye nokuvavanywa kwentliziyo I-X-ray Biopsy: Isampulu encinci yethishu ithathwa kwilonda le-KS. Uvavanyo lwe-CT olunokwenzeka. Uvavanyo olunokwenzeka lwemiphunga okanye ithumbu lesisu nge-endoscope: Isixhobo esiguqukayo esivavanya ngaphakathi kwilungu. Abathathi-nxaxheba baya kuthatha amachiza kwimijikelo yeeveki ezi-4. Baza kuthatha i-Doxil nge-IV ngo-Day 1 kumjikelo ngamnye. Baya kuthatha iipilisi zeCC-4047 ngomlomo usuku ngalunye kwiiveki zokuqala ezi-3 kumjikelo ngamnye. Abathathi-nxaxheba baya kuba notyelelo oluninzi: Phambi kokuqala unyango Ukuqala kumjikelo ngamnye Usuku lwe-15 kwimijikelo yokuqala emi-2 Utyelelo lubandakanya ukuphinda kuvavanyo lokuvavanywa kwaye: Igazi elininzi litsala iifoto zezilonda. Abathathi-nxaxheba baya kuthatha i-aspirin okanye ezinye iziyobisi ukukhusela amahlwili egazi. Abathathi-nxaxheba abane-HIV baya kuba nonyango oludibeneyo lwe-antiretroviral. Abanye abathathi-nxaxheba baya kuba ne-PET scan. Abathathi-nxaxheba baya kuqhubeka nonyango ukuba nje bayalunyamezela kwaye i-KS yabo iyaphucuka. Emva konyango, baya kuba notyelelo olulandelayo olulandelayo ukuya kuthi ga kwiminyaka emi-5 ... Phambi kokuqala unyango Ukuqala kumjikelo ngamnye uSuku lwe-15 kwimijikelo yokuqala emi-2 Utyelelo lubandakanya ukuphinda kuvavanyo lokuvavanywa kwaye: Igazi elininzi litsala iifoto zezilonda Abathathi-nxaxheba baya kugcina idayari yeziyobisi. Abathathi-nxaxheba baya kuthatha i-aspirin okanye ezinye iziyobisi ukukhusela amahlwili egazi. Abathathi-nxaxheba abane-HIV baya kuba nonyango oludibeneyo lwe-antiretroviral. Abanye abathathi-nxaxheba baya kuba ne-PET scan. Abathathi-nxaxheba baya kuqhubeka nonyango ukuba nje bayalunyamezela kwaye i-KS yabo iyaphucuka. Emva konyango, baya kuba notyelelo olulandelayo olulandelayo ukuya kuthi ga kwiminyaka emi-5 ... Phambi kokuqala unyango Ukuqala kumjikelo ngamnye uSuku lwe-15 kwimijikelo yokuqala emi-2 Utyelelo lubandakanya ukuphinda kuvavanyo lokuvavanywa kwaye: Igazi elininzi litsala iifoto zezilonda Abathathi-nxaxheba baya kugcina idayari yeziyobisi. Abathathi-nxaxheba baya kuthatha i-aspirin okanye ezinye iziyobisi ukukhusela amahlwili egazi. Abathathi-nxaxheba abane-HIV baya kuba nonyango oludibeneyo lwe-antiretroviral. Abanye abathathi-nxaxheba baya kuba ne-PET scan. Abathathi-nxaxheba baya kuqhubeka nonyango ukuba nje bayalunyamezela kwaye i-KS yabo iyaphucuka. Emva konyango, baya kuba notyelelo olulandelayo olulandelayo ukuya kuthi ga kwiminyaka emi-5 ... Abathathi-nxaxheba abane-HIV baya kuba nonyango oludibeneyo lwe-antiretroviral. Abanye abathathi-nxaxheba baya kuba ne-PET scan. Abathathi-nxaxheba baya kuqhubeka nonyango ukuba nje bayalunyamezela kwaye i-KS yabo iyaphucuka. Emva konyango, baya kuba notyelelo olulandelayo olulandelayo ukuya kuthi ga kwiminyaka emi-5 ... Abathathi-nxaxheba abane-HIV baya kuba nonyango oludibeneyo lwe-antiretroviral. Abanye abathathi-nxaxheba baya kuba ne-PET scan. Abathathi-nxaxheba baya kuqhubeka nonyango ukuba nje bayalunyamezela kwaye i-KS yabo iyaphucuka. Emva konyango, baya kuba notyelelo olulandelayo olulandelayo ukuya kuthi ga kwiminyaka emihlanu ...

Indawo: Amaziko kaZwelonke eKliniki, eBethesda, eMaldin