Malunga-nomhlaza / unyango / ulingo lweklinikhi / isifo / isisu-neuroendocrine-ithumba-g1 / unyango

Unyango lwezilingo zoNyango lweeNziki ze-Neuroendocrine Tumor G1

Uvavanyo lwezonyango zizifundo zophando ezibandakanya abantu. Uvavanyo lweklinikhi kolu luhlu lolonyango lwe-gastrointestinal neuroendocrine tumor g1. Zonke izilingo ezikuluhlu ziyaxhaswa yi-NCI.

Ulwazi olusisiseko lwe-NCI malunga nolingo lweklinikhi luchaza iintlobo kunye nezigaba zovavanyo kunye nendlela ezenziwa ngayo. Uvavanyo lwezonyango lujonga iindlela ezintsha zokuthintela, ukufumanisa, okanye ukunyanga izifo. Unokufuna ukucinga ngokuthatha inxaxheba kuvavanyo lweklinikhi. Thetha nogqirha wakho ngoncedo ekunqumeni ukuba ikulungele na.

Iimvavanyo 1-4 ze-4

I-Cabozantinib S-malate ekunyangeni abaguli abane-Neuroendocrine Tumors Ngaphambili iphathwe nge-Everolimus ekuhlaleni e-Advanced, Metastatic, okanye ayinakususwa ngoPhando

Olu phononongo lwesigaba sesithathu sokuvavanywa kwesifundo se-cabozantinib S-malate ukubona ukuba isebenza njani ngokuthelekiswa ne-placebo ekunyangeni abaguli abane-neuroendocrine tumors ngaphambili eyayinyangwa nge-everolimus ethe yasasazeka kwizicubu ezikufuphi okanye i-lymph node, yasasazeka kwezinye iindawo emzimbeni, okanye ayinakho isuswe ngotyando. I-Cabozantinib S-malate sisiyobisi se-chemotherapy esaziwa njenge-tyrosine kinase inhibitor, kwaye sijolise kwi-tyrosine kinase receptors, ethi xa ivaliwe, icothise ukukhula kwethumba.

Indawo: iindawo ezingama-329

I-PEN-221 eSomatostatin Receptor 2 Ukuchaza iiCancer eziPhambili kubandakanya iNeuroendocrine kunye noMhlaza weSifo seMiphunga

Iprotocol ye-PEN-221-001 yileyibhile evulekileyo, inqanaba le-1 / 2a lokuhlola kuvavanywa i-PEN-221 kwizigulana ezine-SSTR2 evakalisa i-gastroenteropancreatic (GEP) okanye imiphunga okanye i-thymus okanye ezinye i-neuroendocrine tumors okanye umhlaza omncinci wesifo somhlaza okanye iseli enkulu ye-neuroendocrine carcinoma yemiphunga.

Indawo: Iindawo ezi-7

I-Ribociclib kunye ne-Everolimus ekunyangeni abaguli abane-Neuroendocrine Tumors yoPhuculo lweMvelaphi ye-Foregut.

Isigaba sesibini sokuvavanywa kwesilingo sokuba i-ribociclib kunye ne-everolimus zisebenza njani ekunyangeni abaguli abane-neuroendocrine tumors yemvelaphi ye-foregut esasazeke kwamanye amalungu omzimba kwaye ihlala ingenakunyangeka okanye ilawulwe ngonyango. I-Ribociclib kunye ne-everolimus inokumisa ukukhula kweeseli zesisu ngokuthintela ezinye ii-enzymes ezifunekayo ekukhuleni kweseli.

Indawo: Iindawo ezi-5

I-Sapanisertib ekunyangeni abaguli abane-Metastatic okanye i-Refractory Pancreatic Neuroendocrine Tumor engenakususwa ngoPhando

Isigaba sesibini sokuvavanywa kwesilingo sendlela esebenza ngayo i-sapanisertib ekunyangeni abaguli abane-pancreatic neuroendocrine tumor ethe yasasazeka kwezinye iindawo emzimbeni (metastatic), ayiphenduli kunyango (i-refractory), okanye ayinakususwa ngotyando. Iziyobisi ezinje nge-sapanisertib zinokumisa ukukhula okanye zinciphise iiseli zesisu ngokuthintela ezinye ii-enzymes ezifunekayo ekukhuleni kweseli.

Indawo: Iindawo ezingama-379