Mhando / nyoro-tishu-sarcoma / murwere / mwana-munyoro-munyama-kurapa-pdq

Yevacheche Nyama Tissue Sarcoma Kurapa (®) -Patient Shanduro

Zveruzhinji Ruzivo Nezve Mwana Nyoro Tissue Sarcoma

PFUNGWA DZINOKOSHA

• Zvepwere zvinyoro zvinyama sarcoma chirwere umo maronda (gomarara) maseru anoumba mumatete akapfava emuviri.

• Soft tissue sarcoma inowanikwa muvana nevakuru.

• Kuva nezvimwe zvirwere uye kusagadzikana kwakagara nhaka kunogona kuwedzera njodzi yehudiki nyoro nyowani sarcoma.

• Chiratidzo chakajairika chehucheche zvinyama zvinyoro sarcoma ibundu risingarwadzi kana kuzvimba mumateru akapfava emuviri.

• Bvunzo dzekuongorora dzinoshandiswa kuona (tsvaga) uye kuongorora hudiki hunyoro hutachiona sarcoma.

• Kana bvunzo dzichiratidza panogona kunge paine nyoro tishu sarcoma, biopsy inoitwa.

• Kune akawanda marudzi akasiyana ezvinyoro zvinyama sarcomas.

• Mafuta emota mamota

• Bone uye cartilage tumarara

• Fibrous (inobatanidza) mamota matumbu

• Skeletal mhasuru mamota

• Smooth mhasuru mamota

• Zvinonzi fibrohistiocytic tumors

• Tsinga sheath mamota

• Pericytic (Perivascular) Mamota

• Tumota dzisingazivikanwe sero kwayakatangira

• Ropa remidziyo mamota

• Zvimwe zvinhu zvinokanganisa kufungidzira (mukana wekupora) uye sarudzo dzekurapa.

Zvepwere zvinyoro zvinyama sarcoma chirwere umo maronda (gomarara) maseru anoumba mumatete akapfava emuviri.

Nyoro nyoro dzomuviri dzinobatanidza, kutsigira, uye kutenderedza dzimwe nhengo dzemuviri uye nhengo. Izvo zvinyoro zvinyoro zvinosanganisira zvinotevera:

• Mafuta.

• Iko kusanganiswa kwemapfupa nekatekete.

• Tubhu twemafuta.

• Tsandanyama.

• Tsinga.

• Tendons (zvisungo zvemucheka zvinobatanidza mhasuru nemapfupa).

• Synovial tishu (tishu dzakakomberedza majoini).

• Tsinga.

• Lymph midziyo.

Soft tishu sarcoma inogona kuwanikwa chero mumuviri. Muvana, mamota anowanzoitika kazhinji mumawoko, makumbo, chifuva, kana dumbu.

Nyoro nyowani sarcoma mafomu mune akapfava materu emuviri, kusanganisira mhasuru, tendon, mafuta, mitsipa yeropa, lymph midziyo, tsinga, uye zvinyama zvakakomberedza majoini.

Soft tissue sarcoma inowanikwa muvana nevakuru.

Soft tissue sarcoma muvana inogona kupindura zvakasiyana pakurapwa, uye inogona kuve nekufungidzira kuri nani pane zvinyoro nyoro sarcoma muvakuru. (Ona pfupiso ye pane Adult Soft Tissue Sarcoma Kurapa kweruzivo nezvekurapa muvakuru.)

Kuva nezvimwe zvirwere uye kusagadzikana kwakagara nhaka kunogona kuwedzera njodzi yehudiki nyoro nyowani sarcoma.

Chero chipi zvacho chinowedzera njodzi yako yekuwana chirwere chinonzi njodzi chinhu. Kuva nenjodzi hazvireve kuti uchawana gomarara; kusava nenjodzi hazvireve kuti hauzobatwe negomarara. Taura nachiremba wemwana wako kana iwe uchifunga kuti mwana wako angave ari panjodzi.

Njodzi zvinhu zvehucheche zvinyama nyoro sarcoma zvinosanganisira kuve nezvinetso zvinotevera zvinotevera.

• Li-Fraumeni chirwere.

• Inowanzozivikanwa adenomatous polyposis (FAP).

• RB1 geni inochinja.

• SMARCB1 (INI1) kuchinja kwemajini.

• Neurofibromatosis mhando 1 (NF1).

• Werner chirwere.

• Tuberous sclerosis.

• Adenosine deaminase-inoshomeka yakaoma inosanganiswa immunodeficiency.

Zvimwe zvinhu zvine njodzi zvinosanganisira zvinotevera:

• Kurapa kwekare ne radiation radiation.

• Kuva neAIDS (inowana immune deficiency syndrome) uye Epstein-Barr hutachiona hutachiona panguva imwe chete.

Chiratidzo chakajairika chehucheche zvinyama zvinyoro sarcoma ibundu risingarwadzi kana kuzvimba mumateru akapfava emuviri.

Sarcoma inogona kuoneka sebundu risingarwadzi pasi peganda, kazhinji paruoko, gumbo, chifuva, kana dumbu. Panogona kunge pasina zvimwe zviratidzo kana zviratidzo pakutanga. Sezvo sarcoma ichikura uye ichimanikidza nhengo dziri pedyo, tsinga, mhasuru, kana tsinga dzeropa, zvinogona kukonzera zviratidzo kana zviratidzo, sekurwadziwa kana kushaya simba.

Dzimwe mamiriro anogona kukonzera iwo iwo iwo zviratidzo nezviratidzo. Tarisa nechiremba wemwana wako kana mwana wako ane chero eaya matambudziko.

Bvunzo dzekuongorora dzinoshandiswa kuona (tsvaga) uye kuongorora hudiki hunyoro hutachiona sarcoma.

Iyi inotevera bvunzo uye maitiro anogona kushandiswa:

• Kuongorora kwepanyama uye nhoroondo: Kuongororwa kwemuviri kutarisa zviratidzo zvehutano, kusanganisira kuongorora zviratidzo zvehosha, zvakadai semapundu kana chero chinhu chinoratidzika sechisina kujairika. Nhoroondo yemaitiro ehutano hwemurwere uye kurwara kwakapfuura uye kurapwa kuchatorwawo.

• X-rays: X-ray imhando yesimba remagetsi rinogona kupfuura nemuviri kupinda mufirimu, richiita mifananidzo yenzvimbo dziri mukati memuviri.

• MRI (magnetic resonance imaging): Maitiro anoshandisa magineti, masaisai eredhiyo, uye komputa kugadzira yakateedzana mifananidzo yakajeka yenzvimbo dzemuviri, senge chipfuva, dumbu, maoko, kana makumbo. Iyi nzira inonziwo nyukireya magnetic resonance imaging (NMRI).

Magnetic resonance imaging (MRI) yedumbu. Mwana akarara patafura inotsvedza ichipinda muMRI scanner, inotora mifananidzo yemukati memuviri. Iyo padhi padumbu remwana inobatsira kujekesa mifananidzo.

• CT scan (CAT scan): Maitiro anoita akateedzana emifananidzo yakajeka yenzvimbo dziri mukati memuviri, senge chipfuva kana dumbu, zvakatorwa kubva kumakona akasiyana. Mifananidzo yacho inogadzirwa nekombuta yakabatana neiyo x-ray muchina. Dhayi inogona kuiswa jekiseni kana kumedzwa kubatsira nhengo kana zvinyama kuratidza zvakajeka. Iyi nzira inonziwo computed tomography, computerized tomography, kana komputa axial tomography.

Computed tomography (CT) scan yemudumbu. Mwana akarara patafura inotsvedza kuburikidza neCT scanner, iyo inotora mifananidzo ye x-ray yemukati medumbu.

• Ultrasound bvunzo: Maitiro umo ma-high-energy ruzha mafungu (ultrasound) anodonhedzwa kubva mukati memukati nyama kana nhengo uye anoita maungira. Maungira anoumba mufananidzo wemuviri munyama unonzi sonogram. Mufananidzo wacho unogona kudhindwa kuti utariswe gare gare.

Kana bvunzo dzichiratidza panogona kunge paine nyoro tishu sarcoma, biopsy inoitwa.

Rudzi rwebiopsy runotsamira, muchidimbu, pahukuru hwehukuru uye kana iri padyo nechepamusoro peganda kana yakadzika munyama. Imwe yemhando dzinotevera dze biopsies inowanzo shandiswa:

• Core tsono biopsy: Kubviswa kwetishu uchishandisa yakakura tsono. Akawanda matissue sampuli anotorwa. Maitiro aya anogona kutungamirwa uchishandisa ultrasound, CT scan, kana MRI.

• Incisional biopsy: Kubviswa kwechikamu chebundu kana sampuro yetishu.

• Excisional biopsy: Kubviswa kwebundu rese kana nzvimbo yetishu isingatarise seyakajairika. Nyanzvi yezvirwere anoona tishu pasi pe microscope kutsvaga maseru ekenza. Biopsy inoshamisa inogona kushandiswa kubvisa zvachose mamota mashoma ari padyo nechepamusoro peganda. Rudzi rwebiopsy haruwanzoshandiswa nekuti cancer maseru anogona kusara mushure meiyo biopsy. Kana masero ekenza akasara, gomarara rinogona kudzoka kana kupararira kune dzimwe nhengo dzemuviri.

Iyo MRI yebundu inoitwa pamberi pekunakidzwa biopsy. Izvi zvinoitirwa kuratidza kuti bundu rekutanga rakaumbwa kupi uye rinogona kushandiswa kutungamira kuvhiyiwa mune ramangwana kana kurapwa nemwaranzi.

Kana zvichibvira, chiremba anovhiya uyo achabvisa chero bundu rinowanikwa anofanirwa kuve nechekuita pakuronga biopsy. Kuiswa kwetsono kana kukamurwa kweiyo biopsy kunogona kukanganisa kana bundu rose rinogona kubviswa panguva yekuvhiyiwa kwakazotevera.

Kugadzirira kurapa kwakanyanya, muyenzaniso wetissue wakabviswa panguva yebiopsy unofanirwa kunge wakakura zvakakwana kuti uwane mhando yesoftoma yetissue sarcoma uye nekuita kumwe kuyedzwa kwerabhoritari. Masampuli etishu anotorwa kubva kune yekutanga bundu, lymph node, uye dzimwe nzvimbo dzinogona kuve nekenza maseru. Nyanzvi yezvirwere anoona munyama pasi pe microscope kutsvaga maseru egomarara uye kuti aone mhando nebanga rebundu racho. Chikamu chebundu chinoenderana nekuti masero ekenza anotarisa zvakadii pasi pe microscope uye nekukurumidza maseru ari kuganhura. Mamota epamusoro-giredhi uye epakati-giredhi anowanzo kukura nekupararira nekukurumidza kupfuura akadzika-giredhi mamota.

Nekuti zvinyoro nyoro sarcoma inogona kunetsa kuti iongororwe, iyo sampuli sampu inofanira kuongororwa nachiremba wezvirwere ane ruzivo rwekuongorora yakapfava tishu sarcoma.

Imwe kana kupfuura eanotevera eongororo yeirabhorari angaitwe kuti aongorore iwo matissue sampuli:

• Molecular test: Kuedzwa kwerabhoritari kutarisa mamwe majeni, mapuroteni, kana mamwe mamorekuru mune sampu yetishu, ropa, kana imwe mvura yemuviri. Chiyero chemamorekuru chingaitwe nedzimwe nzira, senge biopsies, kubatsira kuongorora dzimwe mhando dzekenza. Mamorekuru bvunzo anotarisa kune mamwe magene kana echromosome shanduko inoitika mune mamwe manyoro matema sarcomas.

• Reverse transcript- polymerase chain reaction (RT – PCR) bvunzo: Kuongororwa kwerabhoritari umo huwandu hwechibereko chinonzi mRNA chakagadzirwa neimwe geni chinoyerwa. Enzyme inonzi reverse transcriptase inoshandiswa kushandura chidimbu cheRNA kuita chidimbu cheDNA, icho chinogona kukwidziridzwa (chakaitwa muzvizhinji) neimwe enzyme inonzi DNA polymerase. Akawedzeredzwa maDNA makopi anobatsira kutaurira kana chaiyo mRNA iri kugadzirwa negene. RT-PCR inogona kushandiswa kuongorora kumisikidza kwemamwe majeni anogona kuratidza kuvepo kwemasero ekenza. Iyi bvunzo inogona kushandiswa kutsvaga kumwe kuchinjika mugene kana chromosome, iyo inogona kubatsira kuongorora kenza.

• Kuongorora kweCytogenetic: Kuedzwa kwerabhoritari umo ma chromosomes emaseru mune imwe sampu yematumbo inoverengwa uye kuongororwa chero shanduko, dzakadai sekutyoka, kushaikwa, kugadziriswazve, kana mamwe ma chromosomes. Shanduko mune mamwe ma chromosomes inogona kunge iri chiratidzo checancer. Kuongorora kweCytogenetic kunoshandiswa kubatsira kuongorora cancer, kuronga kurapwa, kana kuona kuti kurapa kuri kushanda sei. Fluorescence in situ kusanganiswa (FISH) rudzi rwe cytogenetic ongororo.

• Immunocytochemistry: Kuongororwa kwerabhoritari inoshandisa masoja ekudzivirira mamwe maantigen (mamaki) mune imwe sampuli yemasero emurwere. Masoja ekudzivirira chirwere anowanzo sunganidzwa ne enzyme kana dhayi ye fluorescent. Mushure mekunge maantibodies akasunga kune antigen mune muyero wemasero emurwere, iyo enzyme kana dhayi inoitwa, uye antigen inogona kuzoonekwa pasi pe microscope. Rudzi urwu rweyedzo runogona kushandiswa kutaurira mutsauko pakati pemhando dzakasiyana dzesoftoma sarcoma.

• Chiedza uye elektroni microscopy: Kuongororwa kwerabhoritari umo masero ari mune imwe sampu yetishu anoonekwa pasi pemaikorosikopu akajairwa uye akakwirira-simba kuti atsvage kumwe kushanduka mumasero.

Kune akawanda marudzi akasiyana ezvinyoro zvinyama sarcomas.

Masero erudzi rumwe nerumwe rwe sarcoma anotaridzika akasiyana pasi pe microscope. Iwo mamota ane zvinyoro-nyoro akarongwa zvichienderana nerudzi rweyakatsetseka tishu maseru kwavakatanga kuumba.

Ichi chidimbu chiri pamusoro pemhando dzinotevera dzeasoftoma sarcoma:

Mafuta emota mamota

Liposarcoma. Ichi kenza yemafuta maseru. Liposarcoma kazhinji inoumba mumafuta ezasi pasi peganda. Muvana nevechiri kuyaruka, liposarcoma inowanzo iri yakadzika giredhi (inogona kukura nekupararira zvishoma nezvishoma). Kune mhando dzakasiyana dze liposarcoma, kusanganisira:

• Myxoid liposarcoma. Iyi kazhinji kenza yepasi-yegiredhi inopindura mushe pakurapwa.

• Pleomorphic liposarcoma. Iyi kazhinji kenza yegiredhi repamusoro isinganyanyo kupindura mushe pakurapwa.

Bone uye cartilage tumarara

Bone uye cartilage tumors musanganiswa wemapfupa maseru uye maseru eronda. Bone uye cartilage tumors zvinosanganisira anotevera marudzi:

• Yakawedzera mesenchymal chondrosarcoma. Rudzi urwu rwefupa uye cartilage bundu rinowanzo bata vechidiki vakuru uye rinoitika mumusoro nemutsipa.

• Yakawedzera osteosarcoma. Rudzi urwu rwefupa uye cartilage bundu rakajairika muvana nevechiri kuyaruka. Iyo inogona kudzoka mushure mekurapa uye inogona kupararira kumapapu.

Fibrous (inobatanidza) mamota matumbu

Fibrous (inobatanidza) mamota ematumbo anosanganisira aya anotevera marudzi:

• Desmoid-type fibromatosis (inonziwo desmoid tumor kana hasha fibromatosis). Iyi fibrous tishu bundu iri rakadzika giredhi (inogona kukura zvishoma nezvishoma). Inogona kudzoka munyama dziri padyo asi kazhinji haina kupararira kunzvimbo dziri kure dzomuviri. Dzimwe nguva desmoid-mhando fibromatosis inogona kumira kukura kwenguva yakareba. Kazhinji, bundu rinogona kunyangarika pasina kurapwa.

Desmoid tumors dzimwe nguva inoitika muvana vane shanduko muAPC geni. Shanduko mune iri geni dzinogona zvakare kukonzera yemhuri adenomatous polyposis (FAP). FAP inzvimbo inogarwa nhaka (inopfuudzwa kubva kuvabereki kuenda kuvana) mune akawanda polyps (anokura pane mucous membranes) anoumba mukati memadziro emukati yekoloni uye rectum. Genetic counselling (hurukuro neanodzidziswa nyanzvi nezvezvirwere zvakagarwa nhaka uye sarudzo dzekuongorora majini) zvinogona kudiwa.

• Dermatofibrosarcoma protuberans. Iri ibundu renzvimbo dzakadzika dzeganda dzinowanzo gadzirwa mutangi, maoko, kana makumbo. Maseru ebundu iri ane imwe shanduko yemagene inonzi translocation (chikamu cheCOL1A1 gene inoshandura nzvimbo ine chikamu cheiyo PDGFRB gene). Kuti uongorore dermatofibrosarcoma protuberans, maseru emota anotariswa shanduko iyi. Dermatofibrosarcoma protuberans kazhinji haina kupararira kune lymph node kana zvimwe zvikamu zvemuviri.

• Inopisa myofibroblastic bundu. Gomarara iri rinoumbwa nemaseru emasuru, maseru ehukama, uye mamwe maseru ekudzivirira. Izvo zvinoitika muvana nevechiri kuyaruka. Iyo inowanzo kuve inoumba mune yakapfava tishu, mapapu, spleen, uye chipfuva. Inowanzo dzoka mushure mekurapwa asi isingawanzo kupararira kumativi ari kure emuviri. Imwe shanduko yemajini yakawanikwa mune inenge hafu yemamota aya.

Fibrosarcoma.

Kune maviri marudzi e fibrosarcoma muvana nevechiri kuyaruka:

• Infantile fibrosarcoma (inonziwo congenital fibrosarcoma). Rudzi urwu rwe fibrosarcoma runowanzoitika muvana vane makore 1 gore uye mudiki uye vanogona kuonekwa mune yepacheche ultrasound bvunzo. Bundu iri riri kukura nekukurumidza uye rinowanzo kuve rakakura pakuongororwa. Izvo hazviwanzo kupararira kumativi ari kure emuviri. Iwo maseru ebundu iri anowanzo kuve nehumwe shanduko yemagene inonzi translocation (chikamu cheimwe chromosome inoshandura nzvimbo ine chikamu cheimwe chromosome). Kuti uongorore infile fibrosarcoma, maseru emota anotariswa shanduko iyi. Bundu rakafanana rakaonekwa muvana vakura, asi harina translocation iyo inowanzoonekwa muvana vadiki.

• Munhu mukuru fibrosarcoma. Iyi ndiyo imwechete iyo fibrosarcoma inowanikwa muvakuru. Maseru eiyi bundu haana shanduko yemavara inowanikwa mune yecheche fibrosarcoma. (Ona pfupiso ye pane Adult Soft Tissue Sarcoma Kurapa kuti uwane rumwe ruzivo.)

• Myxofibrosarcoma. Ichi chinhu chisingawanzo shamhu bundu bundu rinoitika kushoma kazhinji muvana kupfuura muvakuru.

• Yakadzika-giredhi fibromyxoid sarcoma. Iri ibundu rinokura zvishoma-zvishoma iro rinoumba rakadzika mumaoko kana makumbo uye rinonyanya kubata vechidiki uye vezera repakati. Bundu rinogona kudzoka makore mazhinji mushure mekurapwa uye ndokupararira kumapapu uye kumadziro echipfuva. Kutevera kweupenyu hwese kunodiwa.

• Sclerosing epithelioid fibrosarcoma. Ichi hachina kujairika chine fibrous tishu bundu rinokura nekukurumidza. Inogona kudzoka ndokupararira kune mamwe mativi emuviri makore mushure mekurapwa. Yenguva refu yekutevera inodiwa.

Skeletal mhasuru mamota

Tsandanyama yemhasuru yakasungirirwa pamapfupa uye inobatsira muviri kufamba.

• Rhabdomyosarcoma. Rhabdomyosarcoma ndiyo yakajairika kuvana vadiki nyoro sarcoma yevana mu14 makore uye mudiki. (Ona pfupiso yePDPQ paChidiki Rhabdomyosarcoma Kurapa kuti uwane rumwe ruzivo.)

Smooth mhasuru mamota

Smooth mhasuru mitsara mukati memidzi yeropa uye isina mhango nhengo dzemukati senge dumbu, ura, dundira, uye chibereko.

• Leiomyosarcoma. Iri bundu remhasuru rakatsetseka rakabatana nehutachiona hweEpstein-Barr muvana vane zvakare HIV kana AIDS. Leiomyosarcoma inogona zvakare kuita sekenza yechipiri muvapenyu veinotora retinoblastoma, dzimwe nguva makore mazhinji mushure mekutanga kurapwa kwe retinoblastoma.

Zvinonzi fibrohistiocytic tumors

• Plexiform fibrohistiocytic bundu. Ichi chibundu chisingawanzoitika chinowanzo bata vana nevakuru vechidiki. Bundu rinowanzo kutanga sekukura kusingarwadzi kana kana pasi peganda paruoko, ruoko, kana ruoko. Iyo inogona kashoma kupararira kune lymph node iri padyo kana kumapapu.

Tsinga sheath mamota

Iyo sheath sheath inoumbwa nemidziyo yekudzivirira yemyelin inovhara maseru etsinga asiri chikamu chehuropi kana musana. Nerve sheath tumors inosanganisira aya anotevera marudzi:

• Inotyisa peripheral nerve sheath bundu. Vamwe vana vane hutachiona hwehutachiona hwehutachiona hwehutachiona vane hutachiona husingawanzozivikanwa hunonzi neurofibromatosis type 1 (NF1). Bundu iri rinogona kunge riri rakaderera giredhi kana rakakwira giredhi.

• Yakashata Triton bundu . Aya ndiwo mamota ari kukura nekukurumidza anoitika kazhinji muvana vane NF1.

• Ectomesenchymoma. Iri ibundu rinokurumidza kukura rinoitika kunyanya muvana. Ectomesenchymomas inogona kuumba musoketi yeziso, dumbu, maoko, kana makumbo.

Pericytic (Perivascular) Mamota

Pericytic tumors inoumba mumasero anomonera kumativi eropa. Pericytic mamota anosanganisira anotevera marudzi:

• Myopericytoma. Infantile hemangiopericytoma rudzi rwe myopericytoma. Vana vari pasi pegore rimwe panguva yekuongororwa vanogona kuve nekufungidzira kuri nani. Mune varwere vakura kupfuura gore rimwe chete, infantile hemangiopericytoma iri mukana wekupararira kune dzimwe nhengo dzemuviri, kusanganisira ma "lymph node" nemapapu.

• Mucheche myofibromatosis. Infantile myofibromatosis ndeimwe mhando ye myopericytoma. Iyo fibrous bundu rinowanzoitika mumakore ekutanga maviri emakore ehupenyu. Panogona kunge paine nodule rimwe pasi peganda, kazhinji mumusoro nemutsipa nzvimbo (myofibroma), kana manhamba mazhinji paganda, mhasuru, kana pfupa (myofibromatosis). Mune varwere vane vacheche myofibromatosis, kenza inogonawo kupararira kune nhengo. Aya mamota anogona kuenda pasina kurapwa.

Tumota dzisingazivikanwe sero kwayakatangira

Tumota dzisingazivikanwe maseru mavambo (mhando yesero bundu rakatanga kuumbwa mukati harizivikanwe) inosanganisira anotevera marudzi:

• Synovial sarcoma. Synovial sarcoma rudzi rwakajairika rwezvinyoro zvinyama sarcoma muvana nevechiri kuyaruka. Iyo inowanzo kuumba munyama dzakakomberedza majoini mumaoko kana makumbo, asi inogona zvakare kuumbika mudhiramu, musoro, kana mutsipa. Iwo maseru ebundu iri anowanzo kuve nehumwe shanduko yemagene inonzi translocation (chikamu cheimwe chromosome inoshandura nzvimbo ine chikamu cheimwe chromosome). Mamota mahombe ane njodzi huru yekupararira kune dzimwe nhengo dzemuviri, kusanganisira mapapu. Vana vari pasi pemakore gumi vane bundu riri masendimita mashanu kana diki uye rakagadzirwa mumaoko kana makumbo vane fungidziro iri nani.

• Epithelioid sarcoma. Iyi sarcoma isingawanzoitika iyo inowanzo tanga yakadzika munyama dzakapfava sekukura zvishoma, bundu rakasimba uye rinogona kupararira kune ma lymph node. Kana kenza yakaumbwa mumaoko, makumbo, kana magaro, sentinel lymph node biopsy inogona kuitwa kutarisa kenza mune iyo lymph node.

• Alveolar yakapfava chikamu sarcoma. Iri ibundu risingawanzo rezvinyoro zvinotsigira zvinyoro zvinobatanidza nekukomberedza mitezo nedzimwe nyama. Iyo inowanzo fomu mumawoko nemakumbo asi inogona kuitika munyama dzemuromo, shaya, uye kumeso. Inogona kukura zvishoma nezvishoma uye kazhinji inopararira kune dzimwe nhengo dzomuviri. Alveolar nyoro chikamu sarcoma inogona kuve nekufungidzira kuri nani kana bundu racho riine masendimita mashanu kana diki kana kana bundu rabviswa zvachose nekuvhiyiwa. Iwo maseru eiri bundu anowanzo kuve nehumwe shanduko yemageneti inonzi translocation (chikamu cheASSPL gene inoshandura nzvimbo ine chikamu cheTFE3 gene). Kuti uongorore alveolar nyoro chikamu sarcoma, mamota maseru anotariswa nekuda kweiyi geni shanduko.

• Bvisa cell sarcoma yezvinyoro zvinyama. Ichi chi bundu chinyoro chinokura zvishoma chinotanga mune tendon (yakaoma, ine tambo, tambo-senge turu inobatanidza mhasuru kusvika pfupa kana kune chimwe chikamu chemuviri). Bvisa cell sarcoma inowanzoitika mumatumbu akadzika etsoka, chitsitsinho, uye ankle. Inogona kupararira kune lymph nodes iri pedyo. Maseru eichi bundu anowanzove neshanduko yemagineti inonzi translocation (chikamu cheESW1 gene inoshandura nzvimbo ine chikamu cheATF1 kana CREB1 gene). Kuti uongorore yakajeka cell sarcoma yezvinyoro zvinyama, mamota maseru anotariswa nekuda kweiyi geni shanduko.

• Yakawedzera myxoid chondrosarcoma. Rudzi urwu rwezvinyoro zvinyama sarcoma zvinogona kuitika muvana nevechiri kuyaruka. Nekufamba kwenguva, inowanzopararira kune dzimwe nhengo dzomuviri, kusanganisira ma "lymph node" nemapapu. Bundu rinogona kudzoka makore mazhinji mushure mekurapwa.

• Yakawedzera Ewing sarcoma. Ona pfupiso ye paEwing Sarcoma Kurapa kweruzivo.

• Desmoplastic diki kutenderera sero bundu. Iri bundu rinowanzo kuumbwa mu peritoneum mudumbu, chiuno, uye / kana peritoneum muchikanda, asi inogona kuumbika muitsvo kana dzimwe nhengo dzakasimba. Mazana emamota mashoma anogona kuitika mu peritoneum. Desmoplastic diki rakatenderera sero bundu rinogonawo kupararira kumapapu uye zvimwe zvikamu zvemuviri. Iwo maseru ebundu iri anowanzo kuve nehumwe shanduko yemagene inonzi translocation (chikamu cheimwe chromosome inoshandura nzvimbo ine chikamu cheimwe chromosome). Kuti uongorore desmoplastic diki rakatenderera sero bundu, mamota maseru anoongororwa kune ino shanduko.

• Kuwedzera-renal (extracranial) rhabdoid bundu. Iri bundu rinokura nekukurumidza rinoumba mune dzakapfava nyama dzakadai sechiropa uye dundira. Inowanzoitika muvana vadiki, kusanganisira vacheche, asi zvinogona kuitika kuvana vakura nevakuru. Rhabdoid tumors inogona kusanganiswa neshanduko mune bundu rinodzvinyirira geni inonzi SMARCB1. Mhando iyi yegene inogadzira protein inobatsira kudzora kukura kwesero. Shanduko mune iyo SMARCB1 geni inogona kugarwa nhaka. Genetic counselling (hurukuro nehunyanzvi hwakadzidziswa nezvezvirwere zvakagarwa nhaka uye zvingangodiwa pakuongororwa kwemajini) zvinogona kudikanwa.

• Perivascular epithelioid maseru mamota (PEComas). Benign PEComas inogona kuitika kuvana vane hunhu hwakagara nhaka hunonzi tuberous sclerosis. Izvo zvinoitika mudumbu, ura, mapapu, uye nhengo dzejenitourinary. PEComas inokura zvishoma uye mazhinji haigone kupararira.

• Isina kukosheswa / isina unassassified sarcoma. Aya mamota anowanzoitika mumapfupa kana mhasuru dzakanamatira kumabhonzo uye izvo zvinobatsira muviri kufamba.

• Undifferentiated pleomorphic sarcoma / yakaipa malibrous histiocytoma (yakakwira-giredhi). Rudzi urwu rwezvinyoro zvinyama bundu rinogona kuumba muzvikamu zvemuviri uko varwere vakagamuchira kurapwa nemwaranzi munguva yakapfuura, kana sekenza yechipiri muvana vane retinoblastoma. Bundu rinowanzo kuumbwa mumaoko kana makumbo uye rinogona kupararira kune dzimwe nhengo dzemuviri. (Ona pfupiso ye paOsteosarcoma uye Malignant Fibrous Histiocytoma yeBone Kurapa kweruzivo nezve yakaipa malibrous histiocytoma yebhonzo.

Ropa remidziyo mamota

Ropa remidzi mamota rinosanganisira anotevera marudzi:

• Epithelioid hemangioendotheliomaoma. Epithelioid hemangioendotheliomas inogona kuitika muvana asi yakajairika muvakuru pakati pemakore makumi matatu kusvika makumi mashanu ekuberekwa. Zvinowanzoitika muchiropa, mapapu, kana pfupa. Dzinogona kunge dzichikurumidza kukura kana kunonoka kukura. Munenge chetatu chezviitiko, bundu rinopararira kune dzimwe nhengo dzomuviri nekukurumidza. (Ona pfupiso ye paChidiki Vascular Tumors Kurapa kuti uwane rumwe ruzivo.)

• Angiosarcoma yezvinyoro zvinyama. Angiosarcoma yezvinyoro zvinyoro ibundu rinokurumidza kukura iro rinoumba mumidziyo yeropa kana lymph lymph mune chero chikamu chemuviri. Mazhinji angiosarcomas ari mukati kana kungori pasi peganda. Avo vari munyama dzakadzika dzakadzika vanogona kuumba muchiropa, spleen, kana mapapu. Ivo vashoma kwazvo muvana, avo dzimwe nguva vane bundu rinopfuura rimwe paganda kana chiropa. Kazhinji, infantile hemangioma inogona kuve angiosarcoma yezvinyoro zvinyama. (Ona pfupiso ye paChidiki Vascular Tumors Kurapa kuti uwane rumwe ruzivo.)

Ona inotevera pfupiso yePDPQ yeruzivo nezve mhando dzesoftoma sarcoma isina kuisirwa muchidimbu ichi:

• Zvechidiki Rhabdomyosarcoma Kurapa

• Ewing Sarcoma Kurapa

• Osteosarcoma uye Malignant Fibrous Histiocytoma yeBone Kurapa

• Zvisingazivikanwe Cancers zveVana Kurapa (gastrointestinal stromal tumors)

Zvimwe zvinhu zvinokanganisa kufungidzira (mukana wekupora) uye sarudzo dzekurapa.

Kufungidzira (mukana wekupora) uye sarudzo dzekurapa dzinoenderana nezvinotevera:

• Chikamu chemuviri kwakatanga kuumbika bundu.

• Kukura uye chiyero chebundu.

• Mhando yezvinyoro zvinyama sarcoma.

• Iyo yakadzika sei bundu iri pasi peganda.

• Kunyangwe bundu rakapararira kune dzimwe nzvimbo mumuviri uye kwarakapararira.

• Huwandu hwebundu rasara mushure mekuvhiyiwa kuti ribvise.

• Kunyangwe radiation radiation yakashandiswa kurapa bundu.

• Kunyangwe kenza ichangobva kuongororwa kana kuti yadzokazve (dzoka).

Matanho eUdiki Nyama Tissue Sarcoma

PFUNGWA DZINOKOSHA

• Mushure mehucheche nyoro nyowani sarcoma yaonekwa, kuyedzwa kunoitwa kuti uone kana gomarara maseru rapararira kune dzimwe nhengo dzemuviri.

• Pane nzira nhatu dzinopararira negomarara mumuviri.

• Gomarara rinogona kutapukira kubva kwarakatanga kuenda kune dzimwe nhengo dzemuviri.

Mushure mehucheche nyoro nyowani sarcoma yaonekwa, kuyedzwa kunoitwa kuti uone kana gomarara maseru rapararira kune dzimwe nhengo dzemuviri.

Maitiro anoshandiswa kutsvaga kana gomarara rapararira mukati menyama yakapfava kana kune dzimwe nhengo dzemuviri inonzi staging. Iko hakuna yakajairwa sisitimu sisitimu yehudiki yakapfava tishu sarcoma

Kuronga kurapwa, zvakakosha kuziva mhando yesoftoma sarcoma, kuti bundu rinogona kubviswa nekuvhiyiwa, uye kana gomarara rapararira kune dzimwe nhengo dzomuviri.

Maitiro anotevera anogona kushandiswa kutsvaga kana kenza yapararira:

• Sentinel lymph node biopsy: Kubviswa kweiyo sentinel lymph node panguva yekuvhiyiwa. Iyo sentinel lymph node ndiyo yekutanga lymph node muboka rema lymph node ekugamuchira lymphatic drainage kubva kune yekutanga bundu. Iyo yekutanga lymph node kenza ingangopararira ichienda kubva kune yekutanga bundu. Chinhu chine radioactive uye / kana dhayi yebhuruu inorohwa padyo nebundu. Icho chinhu kana dhayi inoyerera kuburikidza nemakiromita ducts kuenda kune ma lymph node. Iyo yekutanga lymph node yekugamuchira chinhu kana dhayi inobviswa. Nyanzvi yezvirwere anoona tishu pasi pe microscope kutsvaga maseru ekenza. Kana masero emukenza asingawanikwe, zvinogona kunge zvisiri kudikanwa kubvisa mamwe ma "lymph node". Dzimwe nguva, sentinel lymph node inowanikwa mune anopfuura rimwe boka renzvimbo. Iyi nzira inoshandiswa kune epithelioid uye yakajeka cell sarcoma.

• CT scan (CAT scan): Maitiro anoita akateedzana emifananidzo yakajeka yenzvimbo dziri mukati memuviri, senge chipfuva, chakatorwa kubva kumakona akasiyana. Mifananidzo yacho inogadzirwa nekombuta yakabatana neiyo x-ray muchina. Dhayi inogona kuiswa jekiseni kana kumedzwa kubatsira nhengo kana zvinyama kuratidza zvakajeka. Iyi nzira inonziwo computed tomography, computerized tomography, kana komputa axial tomography.

• PET scan: PET scan inzira yekuwana yakashata tumarara masero mumuviri. Chishoma che radioactive glucose (shuga) inoiswa mutsinga. Iyo PET scanner inotenderera yakatenderedza muviri uye inogadzira mufananidzo wepo glucose iri kushandiswa mumuviri. Malignant tumarara maseru anoratidza kupenya mumufananidzo nekuti anoshanda uye anotora glucose yakawanda kupfuura zvinoita maseru akajairwa. Maitiro aya anonziwo positron emission tomography (PET) scan.

• PET-CT scan: Maitiro anosanganisa iyo mifananidzo kubva kuPET scan uye nekomputa tomography (CT) scan. Iyo PET neCT scan inoitwa panguva imwe chete pamushini mumwe chete. Mifananidzo kubva kumatanho maviri akabatanidzwa kuti iite yakadzama pikicha kupfuura chero bvunzo yaingaite yega.

Pane nzira nhatu dzinopararira negomarara mumuviri.

Kenza inogona kupararira kuburikidza nematinji, iyo lymph system, uye neropa:

• Tishu. Kenza inopararira kubva kwayakatanga nekukura ichipinda munzvimbo dziri pedyo.

• Lymph maitiro. Kenza inopararira kubva kwayakatanga nekupinda muiyo lymph system. Kenza inofamba nemumidziyo yema lymph ichienda kune dzimwe nhengo dzemuviri.

• Ropa. Kenza inopararira kubva payakatanga nekupinda muropa. Kenza inofamba nemidzi yeropa ichienda kune dzimwe nhengo dzemuviri.

Gomarara rinogona kutapukira kubva kwarakatanga kuenda kune dzimwe nhengo dzemuviri.

Kana kenza ikapararira kune chimwe chikamu chemuviri, inonzi metastasis. Cancer maseru anotsemuka kubva kwaakatanga (iro bundu rekutanga) uye achifamba kuburikidza neye lymph system kana ropa.

• Lymph maitiro. Gomarara rinopinda mu "lymph system", rinofamba nemumidziyo ye "lymph", uye rinogadzira bundu (metastatic tumor) mune chimwe chikamu chemuviri.

• Ropa. Kenza inopinda muropa, inofamba nemutsinga dzeropa, yoita bundu (metastatic tumor) mune chimwe chikamu chemuviri.

Iyo metastatic bundu irwo rudzi rwecancer seyakanyanya bundu. Semuenzaniso, kana yakapfava tishu sarcoma ichipararira kuenda kumapapu, maseru ekenza mumapapu ari akapfava maseru sarcoma maseru. Hosha iyi metastatic nyoro tishu sarcoma, kwete kenza yemapapu.

Kudzokororazve uye Kufambira Mberi Kwemwana Nyoro Tisue Sarcoma

Kudzokorora kwehudiki hunyoro sarcoma ikenza iyo yakadzokazve (yakadzoka) mushure mekurapwa. Gomarara rinogona kunge rakadzoka panzvimbo imwechete kana mune mamwe mativi emuviri.

Kufambira mberi kwehucheche hunyoro sarcoma kenza kenza iyo isina kupindura kurapwa.

Kurapa Sarudzo Kuongorora

PFUNGWA DZINOKOSHA

• Kune akasiyana marudzi ekurapa kwevarwere vane hudiki hwakapfava munyama sarcoma.

• Vana vane hudiki hunyoro sarcoma vanofanirwa kurapwa kwavo kwakarongwa nechikwata chevanoona nezvehutano vari nyanzvi pakurapa kenza muvana.

• Kurapa kwehucheche hunyoro sarcoma kunogona kukonzera mhedzisiro.

• Mhando nomwe dzekurapwa kwakajairika dzinoshandiswa:

• Kuvhiya

• Radiation kurapa

• Chemotherapy

• Kucherechedza

• Targeted kurapwa

• Immunotherapy

• Kumwe Kurapa Kwezvinodhaka

• Mhando nyowani dzekurapa dziri kuyedzwa mumakiriniki ekuedzwa.

• Gene kurapa

• Varwere vangangoda kufunga nezve kutora chikamu mukutora kiriniki.

• Varwere vanogona kupinda mumakiriniki miedzo vasati, panguva, kana mushure mekutanga kwavo kenza kurapwa.

• Yekutevera-bvunzo inogona kudikanwa.

Kune akasiyana marudzi ekurapa kwevarwere vane hudiki hwakapfava munyama sarcoma.

Mhando dzakasiyana dzekurapa dzinowanikwa kune varwere vane hudiki hunyoro tishu sarcoma. Mamwe marapirwo akajairwa (iko kurapwa kwazvino kwashandiswa), uye kumwe kuedzwa mumakiriniki ekuedzwa A kurapwa kiriniki kuyedzwa chidzidzo chekutsvaga chakaitirwa kubatsira kuvandudza marapirwo azvino kana kuwana ruzivo marapirwo matsva evarwere vane gomarara. Kana kiriniki miedzo ikaratidza kuti kurapwa kutsva kuri nani pane kwese kurapwa, kurapwa kutsva kunogona kuve kwakajairwa kurapwa.

Nekuti kenza muvana isingawanzo, kutora chikamu mukutongwa kwekiriniki kunofanirwa kutariswa. Mimwe miedzo yekiriniki yakavhurwa chete kune varwere vasina kutanga kurapwa.

Vana vane hudiki hunyoro sarcoma vanofanirwa kurapwa kwavo kwakarongwa nechikwata chevanoona nezvehutano vari nyanzvi pakurapa kenza muvana.

Kurapa kunozoonekwa nachiremba wevana oncologist, chiremba ane hunyanzvi hwekurapa vana vane gomarara. Vanachiremba oncologist vanoshanda nevamwe vatapi vezvehutano vari nyanzvi pakurapa vana vane zvinyoro zvinyama sarcoma uye vanoziva mune dzimwe nzvimbo dzemishonga. Izvi zvinogona kusanganisira chiremba wechiremba ane hunyanzvi hwekudzidziswa mukubviswa kwemaseru macarcomas. Nyanzvi dzinotevera dzinogona kuverengerwa:

• Chiremba wevana.

• Radiation oncologist.

• Chiremba wehematologist.

• Mukoti wechiremba nyanzvi.

• Rehabilitation nyanzvi.

• Nyanzvi yezvepfungwa.

• Wezvemagariro.

• Mwana-hupenyu nyanzvi.

Kurapa kwehucheche hunyoro sarcoma kunogona kukonzera mhedzisiro.

Kuti uwane ruzivo nezve mhedzisiro inotanga panguva yekurapa kenza, ona yedu Side Mhedzisiro peji.

Zvimwe zvinokonzeresa kubva pakurapwa nekenza zvinotanga mushure mekurapwa uye kuenderera kwemwedzi kana makore zvinonzi kunonoka kuitika Kwapera nguva mhedzisiro yekurapwa nekenza inogona kusanganisira:

• Zvinetso zvepanyama.

• Shanduko mumanzwiro, manzwiro, kufunga, kudzidza, kana ndangariro.

• Gomarara repiri (mhando nyowani dzekenza).

Mimwe mhedzisiro mhedzisiro inogona kurapwa kana kudzorwa. Izvo zvakakosha kuti utaure navanachiremba vemwana wako nezve mhedzisiro yekurapwa nekenza kunogona kuve pamwana wako. (Ona pfupiso ye paMagumo Ekurapa kweKenza Yevacheche kuti uwane rumwe ruzivo.)

Mhando nomwe dzekurapwa kwakajairika dzinoshandiswa:

Kuvhiya

Kuvhiya kubvisa zvinyoro nyoro sarcoma kunoitwa pazvinogoneka. Kana bundu iri rakakura kwazvo, kurapwa nemwaranzi kana chemotherapy kunogona kupihwa pekutanga, kuita kuti bundu rive diki uye kudzikisa huwandu hweturu hunoda kubviswa panguva yekuvhiyiwa. Izvi zvinonzi neoadjuvant (preoperative) kurapa.

Aya anotevera marudzi ekuvhiya anogona kushandiswa:

• Kunakidzwa kwese kwenzvimbo: Kubvisa bundu pamwe chete nemamwe maturusi akaipoteredza.

• Kudimburwa: Kuvhiya kubvisa zvese kana chikamu cheruoko kana gumbo nekenza.

• Lymphadenectomy: Kubviswa kwema lymph node nekenza.

• Mohs Kuvhiya: Maitiro ekuvhiya anoshandiswa kurapa kenza paganda. Matanho ega ega echirwere chegomarara anobviswa uye otariswa pasi pemaikorosikopu imwe panguva kusvikira zvese zvegomarara zvabviswa. Iyi mhando yekuvhiya inoshandiswa kurapa dermatofibrosarcoma protuberans.

Iyo inonziwo Mohs micrographic kuvhiyiwa.

• Hepatectomy: Kuvhiya kubvisa zvese kana chikamu chechiropa.

Kuvhiya kwechipiri kunogona kudikanwa ku:

• Bvisa chero masero egomarara asara.

• Tarisa nzvimbo yakatenderedza pakabviswa bundu kuti riongororwe maseru egomarara wozobvisa mamwe matissue kana zvichidikanwa

Kana gomarara riri muchiropa, hepatectomy uye kuisirwa chiropa zvinogona kuitwa (chiropa chinobviswa chotsiviwa neine hutano kubva kune anenge apa).

Mushure mekunge chiremba abvisa kenza yese inoonekwa panguva yekuvhiyiwa, vamwe varwere vanogona kupihwa chemotherapy kana radiation radiation mushure mekuvhiyiwa kuuraya chero gomarara maseru akasara. Mushonga wakapihwa mushure mekuvhiyiwa, kudzikisa njodzi yekuti gomarara richadzoka, inonzi adjuvant therapy.

Radiation kurapa

Radiation kurapa kurapwa kenza iyo inoshandisa yakakwira-simba x-rays kana mamwe marudzi e radiation kuuraya cancer maseru kana kuachengeta iwo kuti asakure. Kune mhando mbiri dze radiation radiation:

• External radiation therapy inoshandisa muchina uri kunze kwemuviri kutumira radiation kune kenza. Dzimwe nzira dzekupa mishonga ye radiation dzinogona kubatsira kuchengetedza mwaranzi kubva mukukuvadza nyama iri pedyo ine hutano. Iyi mhando ye radiation radiation inogona kusanganisira zvinotevera:

• Stereotactic muviri radiation radiation: Stereotactic muviri radiation radiation rudzi rwekunze radiation radiation. Zvishandiso zvakakosha zvinoshandiswa kuisa murwere munzvimbo imwechete kune imwe neimwe radiation kurapwa. Kamwe pazuva kwemazuva akati wandei, muchina we radiation unovavarira mwero wakakura kupfuura wenguva dzose wemwaranzi yakananga pabundu. Nekuva nemurwere munzvimbo imwechete yekurapwa kwega kwega, pane kukuvara kudiki kune zvinyama zviri pedyo zvine hutano. Maitiro aya anonziwo stereotactic ekunze-beam radiation kurapwa uye stereotaxic radiation kurapwa.

• Yemukati radiation kurapwa kunoshandisa radioactive chinhu chakavharirwa mune tsono, mhodzi, waya, kana makateti anoiswa akananga mukati kana padyo nekenza.

Kunyangwe iyo radiation radiation inopihwa pamberi kana mushure mekuvhiyiwa kubvisa kenza zvinoenderana nemhando uye nhanho yekenza iri kurapwa, kana paine maseru ekenza akasara mushure mekuvhiyiwa, uye nezvinotarisirwa mhedzisiro yekurapa Kunze uye kwemukati kurapwa kwemwaranzi kunoshandiswa kurapa hudiki hunyoro tishu sarcoma.

Chemotherapy

Chemotherapy mushonga wekenza unoshandisa mishonga kumisa kukura kwemasero ekenza, kungave nekuuraya maseru kana nekuamisa iwo kubva pakupatsanuka. Kana chemotherapy ikatorwa nemuromo kana kujowa mutsinga kana mhasuru, mishonga inopinda muropa uye inogona kusvika masero emukenza mumuviri wese (systemic chemotherapy). Kana chemotherapy ikaiswa yakanangana necerebrospinal fluid, nhengo, kana dumbu remuviri senge dumbu, iwo madhiragi anonyanya kukanganisa cancer maseru munzvimbo idzodzo (remunharaunda chemotherapy). Kusanganisa chemotherapy ndiko kushandiswa kweanopfuura imwe anticancer mushonga.

Nzira iyo chemotherapy inopihwa inoenderana nerudzi rweye soft tishu sarcoma iri kurapwa. Mazhinji mhando dzesoftoma sarcoma haapindure pakurapwa nekemotherapy.

Ona Zvinodhaka Zvinotenderwa zveSoft Tissue Sarcoma kuti uwane rumwe ruzivo.

Kucherechedza

Kucherechedza kuri kunyatsoongorora mamiriro emurwere pasina kupa chero kurapwa kusvikira zviratidzo kana zviratidzo zvaonekwa kana kuchinja. Kucherekedza kunogona kuitwa kana:

• Kubvisa kwakazara bundu racho hazvigoneke.

• Hakuna kumwe kurapwa kuripo.

• Bundu harigone kukuvadza chero nhengo dzakakosha.

Kucherechedza kunogona kushandiswa kurapa desmoid-type fibromatosis, infantile fibrosarcoma, PEComa, kana epithelioid hemangioendothelioma.

Targeted kurapwa

Targeted therapy mhando yekurapa inoshandisa zvinodhaka kana zvimwe zvinhu kurwisa cancer maseru. Kurapa kwakanangidzirwa kunowanzo kukonzera kukuvara kudiki kune maseru akajairwa pane kuita chemotherapy kana radiation.

• Kinase inhibitors inovhara enzyme inonzi kinase (rudzi rweprotein). Kune akasiyana marudzi eanase mumuviri ane zviito zvakasiyana.

• ALK inhibitors inogona kumisa kenza kubva pakukura nekupararira. Crizotinib inogona kushandiswa kurapa inoputika myofibroblastic bundu uye infantile fibrosarcoma.

• Tyrosine kinase inhibitors (TKIs) anovharira mamaki anodiwa kuti mamota akure. Imatinib inoshandiswa kurapa dermatofibrosarcoma protuberans. Pazopanib inogona kushandiswa kurapa desmoid-type fibromatosis, epithelioid hemangioendothelioma, uye mamwe marudzi eanodzokororwa uye anopfuurira nyoro nyoro sarcoma. Sorafenib inogona kushandiswa kurapa desmoid-mhando fibromatosis uye epithelioid hemangioendothelioma. Sunitinib inogona kushandiswa kurapa alveolar nyoro chikamu sarcoma. Larotrectinib inoshandiswa kurapa infantile fibrosarcoma. Ceritinib inoshandiswa kurapa hutachiona hwemofibroblastic bundu.

• mTOR inhibitors rudzi rwekurapa kwakanangwa inomisa protein inobatsira maseru kupatsanuka nekurarama. mTOR inhibitors arikushandisa kurapa zvinodzokororwa desmoplastic diki kutenderera maseru mamota, PEComas, uye epithelioid hemangioendothelioma uye irikudzidziswa kuti irape yakaipa malipheral nerve sheath bundu. Sirolimus uye temsirolimus marudzi e mTOR inhibitor therapy.

Mhando nyowani dze tyrosine kinase inhibitors dziri kuongororwa senge:

• Entrectinib yemucheche fibrosarcoma.

• Trametinib ye epithelioid hemangioendotheliomaoma.

Mamwe marudzi eanotarisirwa kurapwa ari kuongororwa mumakiriniki ekuedzwa, kusanganisira zvinotevera:

• Angiogenesis inhibitors rudzi rwekurapa kwakanangwa kunodzivirira kukura kwemidzi mitsva yeropa inodikanwa kuti mamota akure. Angiogenesis inhibitors, senge cediranib, sunitinib, uye thalidomide zviri kuongororwa kurapa alveolar nyoro chikamu sarcoma uye epithelioid hemangioendothelioma. Bevacizumab iri kushandiswa kurapa angiosarcoma.

• Histone methyltransferase (HMT) inhibitors yakanangwa mishonga yekurapa inoshanda mukati memukenza maseru uye inovharira zviratidzo zvinodiwa kuti mamota akure. HMT inhibitors, senge tazemetostat, iri kuongororwa kurapwa kweanokuvadza peripheral nerve sheath tumor, epithelioid sarcoma, extraskeletal myxoid chondrosarcoma, uye extrarenal (extracranial) rhabdoid bundu.

• Heat-shock protein inhibitors inovhara mamwe mapuroteni anodzivirira maseru emota uye anovabatsira kukura. Ganetespib inopisa kupisa protein inhibitor ichidzidzwa pamwe chete ne mTOR inhibitor sirolimus yezvipembenene zvinokuvadza zvetsinga sheath mamota asingakwanise kubviswa nekuvhiya.

• ONA nzira inhibitors rudzi rwekurapa kwakanangwa kunoshanda mukati memukenza maseru uye kunovharira zviratidzo zvinodiwa kuti mamota akure.

ONA nzira inhibitors irikudzidziswa yekurapa desmoid-mhando fibromatosis.

Ona Zvinodhaka Zvinotenderwa zveSoft Tissue Sarcoma kuti uwane rumwe ruzivo.

Immunotherapy

Immunotherapy kurapwa kunoshandisa immune system yemurwere kurwisa gomarara. Zvinhu zvinogadzirwa nemuviri kana kugadzirwa murabhoritari zvinoshandiswa kusimudzira, kunongedza, kana kudzorera kudzivirira kwemuviri kurwisa kenza. Mhando iyi yekurapa inonziwo biotherapy kana biologic therapy.

Interferon uye immune checkpoint inhibitor kurapa ndiwo marudzi eununotherapy.

• Interferon inopesana nekuparadzaniswa kwemaseru maseru uye inogona kudzora bundu kukura. Inoshandiswa kurapa epithelioid hemangioendotheliomaoma.

• Immune checkpoint inhibitor therapy: Dzimwe mhando dzemasero ekudzivirira muviri, senge T maseru, uye mamwe maseru emukenza ane mamwe mapuroteni, anonzi ekuongorora mapuroteni, pamusoro pavo anochengetedza mhinduro dzemumuviri. Kana masero ekenza aine huwandu hwakawanda hweaya mapuroteni, haazorwiswa nekuuraiwa nemaT seli. Immune checkpoint inhibitors inovhara mapuroteni aya uye kugona kwemasero eT kuuraya maseru ekenza kunowedzerwa.

Kune maviri marudzi e immune checkpoint inhibitor therapy:

• CTLA-4 inhibitor: CTLA-4 ipuroteni iri pamusoro peT maseru ayo anobatsira kuchengetedza mhinduro dzemumuviri. CTLA-4 painobatirira kune imwe protein inonzi B7 pane kenza kenza, inomisa iyo T cell kuuraya kenza kenza. CTLA-4 inhibitors inonamira kuCTLA-4 uye inobvumira iwo maseru eT kuuraya maseru ekenza Ipilimumab rudzi rweCTLA-4 inhibitor iyo iri kudzidziswa kurapa angiosarcoma.

Immune checkpoint inhibitor. Checkpoint mapuroteni, akadai seB7-1 / B7-2 pane antigen-anouya maseru (APC) uye CTLA-4 pane T maseru, anobatsira kuchengetedza mhinduro dzemumuviri. Kana iyo T-cell receptor (TCR) inosunga kune antigen uye makuru histocompatibility complex (MHC) mapuroteni paAPC uye CD28 inosunga kuna B7-1 / B7-2 paAPC, iyo T cell inogona kumisikidzwa. Nekudaro, kusunga kweB7-1 / B7-2 kusvika CTLA-4 kunoita kuti maT cell ari munzvimbo isingashande saka havakwanise kuuraya maseru emota mumuviri (kuruboshwe pani). Kuvhara kusunga kweB7-1 / B7-2 kusvika CTLA-4 ine immune checkpoint inhibitor (anti-CTLA-4 antibody) inobvumira iwo maseru eT kuti ave anoshanda uye kuuraya tumarara maseru (kurudyi pani).

• PD-1 inhibitor: PD-1 ipuroteni iri pamusoro peT maseru ayo anobatsira kuchengetedza mhinduro dzemumuviri. Kana PD-1 yakanamatira kune imwe protein inonzi PDL-1 pane kenza kenza, inomisa iyo T cell kuuraya kenza kenza. PD-1 inhibitors inonamira kuPDL-1 uye inobvumira iwo maseru eT kuuraya maseru ekenza. Pembrolizumab rudzi rwePD-1 inhibitor iyo inoshandiswa kurapa inofambira mberi uye inodzokororwa nyoro sarcoma. Nivolumab rudzi rwePD-1 inhibitor iyo iri kudzidziswa kurapa angiosarcoma.

Immune checkpoint inhibitor. Checkpoint mapuroteni, akadai sePD-L1 pane maseru emota uye PD-1 pane T maseru, anobatsira kuchengetedza mhinduro dzemumuviri. Iko kusungwa kwePD-L1 kusvika PD-1 kunoita kuti masero eT arege kuuraya tumarara maseru mumuviri (kuruboshwe pani). Kuvhara kusunga kwePD-L1 kusvika PD-1 ine immune checkpoint inhibitor (anti-PD-L1 kana anti-PD-1) inobvumira iwo maseru eT kuuraya matumbo maseru (kurudyi pani).

Kumwe Kurapa Kwezvinodhaka

Steroid kurapa ine antitumor mhedzisiro mune inoputira myofibroblastic tumors.

Hormone kurapwa kurapa kenza inobvisa mahormone kana ichivhara maitiro avo uye inomisa maseru ekenza kubva mukukura. Mahormone zvinhu zvinogadzirwa nemaronda mumuviri uye zvinotenderera muropa. Mamwe mahormone anogona kukonzera mamwe cancer kuti ikure. Kana bvunzo dzichiratidza kuti maseru egomarara ane nzvimbo dzinogona kubatirira mahormone (receptors), zvinodhaka, kuvhiyiwa, kana kurapwa nemwaranzi kunoshandiswa kudzikisa kugadzirwa kwehormone kana kuvharidzira kushanda. Antiestrogens (zvinodhaka zvinodzivirira estrogen), senge tamoxifen, inogona kushandiswa kurapa desmoid-type fibromatosis. Prasterone iri kudzidziswa kurapwa kwe synovial sarcoma.

Nonsteroidal anti-inflammatory drugs (NSAIDs) mishonga (yakadai seaspirin, ibuprofen, uye naproxen) iyo inowanzo shandiswa kudzora fivha, kuzvimba, kurwadziwa, uye kutsvuka. Mukurapa kwe-desmoid-type fibromatosis, iyo NSAID inonzi sulindac inogona kushandiswa kubatsira kudzivirira kukura kwemasero ekenza.

Mhando nyowani dzekurapa dziri kuyedzwa mumakiriniki ekuedzwa.

Ichi chidimbu chikamu chinotsanangura kurapwa kuri kuongororwa mumakiriniki ekuedzwa. Zvinogona kusataura nezveese marapirwo matsva ari kuongororwa. Ruzivo nezve kiriniki miedzo inowanikwa kubva kuNCI webhusaiti.

Gene kurapa

Gene kurapa kuri kuongororwa kwehucheche synovial sarcoma iyo yakadzokazve, yakapararira, kana isingakwanise kubviswa nekuvhiyiwa. Mamwe masero eT emurwere (rudzi rweropa jena reropa) anobviswa uye magene ari mumasero anoshandurwa murabhoritari (inogadzirwa nemajini) kuitira kuti arwise maseru ekenza. Vanobva vadzoserwa kumurwere nekumukiswa.

Varwere vangangoda kufunga nezve kutora chikamu mukutora kiriniki.

Kune vamwe varwere, kutora chikamu mumuedzo wekiriniki inogona kunge iri sarudzo yekurapa yakanyanya kunaka. Kliniki miedzo chikamu chekenza tsvagiridzo. Zvemakiriniki miedzo inoitwa kuti uone kana marapirwo matsva egomarara akachengeteka uye achishanda kana zvirinani pane akajairwa kurapwa.

Mazhinji emazuva ano marapirwo akajairwa ekenza akavakirwa pamavambo emakiriniki ekuedzwa. Varwere vanotora chikamu mukuyedzwa kwekiriniki vanogona kuwana kurapwa kwakaringana kana kuve pakati pevekutanga kurapwa kutsva.

Varwere vanotora chikamu mumiedzo yekiriniki zvakare vanobatsira kugadzirisa marapirwo achaitwa kenza mune ramangwana. Kunyangwe kana miedzo yemakiriniki isinga tangire kumarapirwo matsva anoshanda, anowanzo pindura mibvunzo yakakosha uye anobatsira kufambisira mberi kutsvagurudza.

Varwere vanogona kupinda mumakiriniki miedzo vasati, panguva, kana mushure mekutanga kwavo kenza kurapwa.

Mimwe miedzo yekiriniki inosanganisira chete varwere vasati vagamuchira kurapwa. Mimwe miedzo yekuedza kurapwa kwevarwere vane kenza haina kuve nani. Kune mamwezve emakiriniki miedzo inoedza nzira nyowani dzekumisa cancer kubva kudzokororazve (kudzoka) kana kudzikisira mhedzisiro yemakenza kurapwa.

Kuedzwa kwemakiriniki kuri kuitika munzvimbo zhinji dzenyika. Ruzivo nezve kiriniki miedzo inotsigirwa neNCI inogona kuwanikwa paNCI yekiriniki miedzo yekutsvaga peji rewebhu. Kliniki miedzo inotsigirwa nemamwe masangano inogona kuwanikwa pane yeClinicalTrials.gov webhusaiti.

Yekutevera-bvunzo inogona kudikanwa.

Mimwe miedzo yakaitwa kuongorora gomarara kana kutsvaga danho rekenza inogona kudzokororwa. Dzimwe bvunzo dzinodzokororwa kuitira kuti vaone kuti kurapa kuri kushanda sei. Sarudzo nezvekuti uenderere mberi, shandura, kana kumisa kurapwa kunogona kunge kuchibva pamhedzisiro yeiyi bvunzo.

Mimwe bvunzo ichaenderera ichiitwa nguva nenguva mushure mekunge kurapwa kwapera. Mhedzisiro yeiyi bvunzo inogona kuratidza kana mamiriro emwana wako achinja kana kana gomarara radzoka (dzoka). Iyi bvunzo dzimwe nguva inonzi yekuteedzera-bvunzo kana kuongorora-kumusoro.

Kurapa Sarudzo dzeNewly Diagnosed Yehucheche Nyama Tissue Sarcoma

Muchikamu chino

• Mafuta Tissue Tumors

• Liposarcoma

• Bone uye Cartilage Tumors

• Yakawedzera mesenchymal chondrosarcoma

• Yakawedzera osteosarcoma

• Fibrous (Inobatanidza) Tissue Tumors

• Desmoid-mhando fibromatosis

• Dermatofibrosarcoma protuberans

• Inopisa myofibroblastic bundu

• Fibrosarcoma

• Myxofibrosarcoma

• Yakadzika-giredhi fibromyxoid sarcoma

• Sclerosing epithelioid fibrosarcoma

• Skeletal Muscle Tumors

• Rhabdomyosarcoma

• Smooth Muscle Tumors

• Leiomyosarcoma

• Izvo zvinonzi Fibrohistiocytic Tumors

• Plexiform fibrohistiocytic bundu

• Nerve Sheath Mamota

• Inotyisa peripheral nerve sheath bundu

• Yakashata Triton bundu

• Ectomesenchymoma

• Pericytic (Perivascular) Mamota

• Mucheche hemangiopericytoma

• Mucheche myofibromatosis

• Tumota dzeKusingazivikanwe Sero Chibviro (iyo nzvimbo yakatanga kuumbwa bundu harizivikanwe

• Synovial sarcoma

• Epithelioid sarcoma

• Alveolar yakapfava chikamu sarcoma

• Bvisa cell sarcoma yezvinyoro zvinyama

• Yakawedzera myxoid chondrosarcoma

• Yakawedzera Ewing sarcoma

• Desmoplastic diki kutenderera sero bundu

• Kuwedzera-renal (extracranial) rhabdoid bundu

• Perivascular epithelioid maseru mamota (PEComas)

• Asina kukodzera / Unclassified Sarcoma

• Undifferentiated pleomorphic sarcoma / yakaipa malibrous histiocytoma (yakakwira-giredhi)

• Ropa Mudziyo Mamota

• Epithelioid hemangioendotheliomaoma

• Angiosarcoma yezvinyoro zvinyama

• Metastatic Yehucheche Nyama Tissue Sarcoma

Kuti uwane ruzivo nezve marapirwo akanyorwa pazasi, ona iyo Chikamu Sarudzo Yekutarisa Chikamu

Mafuta Tissue Tumors

Liposarcoma

Kurapa kwe liposarcoma kunogona kusanganisira zvinotevera:

• Kuvhiya kubvisa zvachose bundu. Kana gomarara risina kubviswa zvachose, kuvhiya kwechipiri kunogona kuitwa.

• Chemotherapy kudzikisa bundu, zvichiteverwa nekuvhiyiwa.

• Radiation kurapwa usati kana mushure mekuvhiyiwa.

Bone uye Cartilage Tumors

Yakawedzera mesenchymal chondrosarcoma

Kurapa kwe extraskeletal mesenchymal chondrosarcoma kunogona kusanganisira zvinotevera:

• Kuvhiya kubvisa zvachose bundu. Radiation kurapa kunogona kupihwa pamberi uye / kana mushure mekuvhiyiwa.

• Chemotherapy inoteverwa nekuvhiyiwa. Chemotherapy ine kana isina radiation radiation inopihwa mushure mekuvhiyiwa.

Yakawedzera osteosarcoma

Kurapa kwe extraskeletal osteosarcoma kunogona kusanganisira zvinotevera:

• Kuvhiya kubvisa zvachose bundu, kuchiteverwa nekemotherapy.

Ona pfupiso yePDPQ paOsteosarcoma uye Malignant Fibrous Histiocytoma yeBone Kurapa kuti uwane rumwe ruzivo nezve kurapwa kweosteosarcoma.

Fibrous (Inobatanidza) Tissue Tumors

Desmoid-mhando fibromatosis

Kurapa kwe-desmoid-type fibromatosis kunogona kusanganisira zvinotevera:

• Kuvhiya kubvisa zvachose bundu.

• Kucherechedza, kwemamota asina kubviswa zvachose nekuvhiyiwa kana akadzokazve (kudzoka) uye asingakwanise kukuvadza chero nhengo dzakakosha.

• Chemotherapy yemamota asina kubviswa zvachose nekuvhiyiwa kana ayo adzokazve.

• Targeted Therapy (sorafenib kana pazopanib).

• Nonsteroidal anti-inflammatory drug (NSAID) kurapa.

• Antiestrogen mishonga yekurapa.

• Radiation kurapa.

• Kuongororwa kwekiriniki kwekurapwa kwakanangwa neNOTCH nzira nzira inhibitor.

Dermatofibrosarcoma protuberans

Kurapa kwe dermatofibrosarcoma protuberans kunogona kusanganisira zvinotevera:

• Kuvhiya kubvisa zvachose bundu kana zvichibvira. Izvi zvinogona kusanganisira kuvhiyiwa kwaMohs.

• Radiation kurapwa usati kana mushure mekuvhiyiwa.

• Radiation therapy uye yakanangwa kurapa (imatinib) kana bundu risingakwanise kubviswa kana kudzoka.

Inopisa myofibroblastic bundu

Kurapa kwechirwere chinoputika myofibroblastic kunogona kusanganisira zvinotevera:

• Kuvhiya kubvisa zvachose bundu kana zvichibvira.

• Chemotherapy.

• Steroid kurapa.

• Nonsteroidal anti-inflammatory drug (NSAID) kurapa.

• Targeted Therapy (crizotinib uye ceritinib).

Fibrosarcoma

Mucheche fibrosarcoma

Kurapa kwecheche fibrosarcoma kunogona kusanganisira zvinotevera:

• Kuvhiya kubvisa bundu pazvinobvira, kuchiteverwa nekucherechedza.

• Kuvhiya kunoteverwa nekemotherapy.

• Chemotherapy kudzikisa bundu, zvichiteverwa nekuvhiyiwa.

• Targeted therapy (crizotinib uye larotrectinib).

• Kuongororwa kwekiriniki kunoongorora muyenzaniso wemota yemurwere kune mamwe magene ekuchinja. Rudzi rwekurapa kwakanangwa kuchapihwa kumurwere kunoenderana nerudzi rwechinjo yemajini.

• Kuongororwa kwekiriniki kweakanangwa kurapwa (larotrectinib kana entrectinib).

Munhu mukuru fibrosarcoma

Kurapa kwevakuru fibrosarcoma kunogona kusanganisira zvinotevera:

• Kuvhiya kubvisa zvachose bundu kana zvichibvira.

Myxofibrosarcoma

Kurapa kwemyxofibrosarcoma kunogona kusanganisira zvinotevera:

• Kuvhiya kubvisa zvachose bundu.

Yakadzika-giredhi fibromyxoid sarcoma

Kurapa kwepasi-giredhi fibromyxoid sarcoma inogona kusanganisira zvinotevera:

• Kuvhiya kubvisa zvachose bundu.

Sclerosing epithelioid fibrosarcoma

Kurapa kwe sclerosing epithelioid fibrosarcoma kunogona kusanganisira zvinotevera:

• Kuvhiya kubvisa zvachose bundu.

Skeletal Muscle Tumors

Rhabdomyosarcoma

Ona pfupiso yePDPQ paChidiki Rhabdomyosarcoma Kurapa.

Smooth Muscle Tumors

Leiomyosarcoma

Kurapa kweiomyosarcoma kunogona kusanganisira zvinotevera:

• Chemotherapy.

Izvo zvinonzi Fibrohistiocytic Tumors

Plexiform fibrohistiocytic bundu

Kurapa kweplexiform fibrohistiocytic bundu kunogona kusanganisira zvinotevera:

• Kuvhiya kubvisa zvachose bundu.

Nerve Sheath Mamota

Inotyisa peripheral nerve sheath bundu

Kurapa kwehutachiona hwehutachiona hwemutsipa hunogona kusanganisira zvinotevera:

• Kuvhiya kubvisa zvachose bundu kana zvichibvira.

• Radiation kurapwa usati kana mushure mekuvhiyiwa.

• Chemotherapy, yemamota asingakwanise kubviswa nekuvhiya.

• Kuongororwa kwekiriniki kunoongorora muyenzaniso wemota yemurwere kune mamwe magene ekuchinja. Rudzi rwekurapa kwakanangwa kuchapihwa kumurwere kunoenderana nerudzi rwechinjo yemajini.

• Kuongororwa kwekiriniki kweakanangwa kurapwa (ganetespib kana sirolimus), yemamota asingakwanise kubviswa nekuvhiya.

• Kuongororwa kwekiriniki yekurapa kwakanangwa (tazemetostat).

Hazvizivikanwe kana kupa radiation radiation kana chemotherapy mushure mekuvhiyiwa kunovandudza mhinduro yemarara pakurapwa.

Yakashata Triton bundu

Malignant Triton mamota anogona kurapwa zvakafanana neRhabdomyosarcomas uye anosanganisira kuvhiyiwa, chemotherapy, kana radiation radiation. Hazvisi pachena kana kupa radiation kurapwa kana chemotherapy kunatsiridza mamota kupindura kurapwa.

Ectomesenchymoma

Kurapa kwe ectomesenchymoma kunogona kusanganisira zvinotevera:

• Kuvhiya.

• Chemotherapy.

• Radiation kurapa.

Pericytic (Perivascular) Mamota

Mucheche hemangiopericytoma

Kurapa kwecheche hemangiopericytoma kunogona kusanganisira zvinotevera:

• Chemotherapy.

Mucheche myofibromatosis

Kurapa kwecheche myofibromatosis kunogona kusanganisira zvinotevera:

Kusanganiswa chemotherapy.

Tumota dzeKusingazivikanwe Sero Chibviro (iyo nzvimbo yakatanga kuumbwa bundu harizivikanwe

Synovial sarcoma

Kurapa kwe synovial sarcoma kunogona kusanganisira zvinotevera:

• Kuvhiya. Radiation therapy uye / kana chemotherapy inogona kupihwa usati kana mushure mekuvhiyiwa.

• Chemotherapy.

• Stereotactic radiation kurapwa kwemamota akapararira kumapapu.

• Kuongororwa kwekiriniki kwemajini kurapwa.

• Kuongororwa kwekiriniki yekurapa kwehomoni.

Epithelioid sarcoma

Kurapa kwe epithelioid sarcoma kunogona kusanganisira zvinotevera:

• Kuvhiya kubvisa bundu pazvinogoneka.

• Chemotherapy.

• Radiation kurapwa usati kana mushure mekuvhiyiwa.

• Kuongororwa kwekiriniki yekurapa kwakanangwa (tazemetostat).

Alveolar yakapfava chikamu sarcoma

Kurapa kwealveolar nyoro chikamu sarcoma kunogona kusanganisira zvinotevera:

• Kuvhiya kubvisa zvachose bundu kana zvichibvira.

• Radiation kurapwa usati kana mushure mekuvhiyiwa, kana bundu risingakwanise kubviswa zvachose nekuvhiyiwa.

• Targeted Therapy (sunitinib).

• Kuongororwa kwekiriniki yekurapa kwakanangwa (cediranib kana sunitinib) yevana.

Bvisa cell sarcoma yezvinyoro zvinyama

Kurapa kweiyo yakajeka cell sarcoma yezvinyoro zvinyoro kunogona kusanganisira zvinotevera:

• Kuvhiya kubvisa bundu pazvinogoneka.

• Radiation kurapwa usati kana mushure mekuvhiyiwa.

Yakawedzera myxoid chondrosarcoma

Kurapa kwe extraskeletal myxoid chondrosarcoma kunogona kusanganisira zvinotevera:

• Kuvhiya kubvisa bundu pazvinogoneka.

• Radiation kurapa.

• Kuongororwa kwekiriniki yekurapa kwakanangwa (tazemetostat).

Yakawedzera Ewing sarcoma

Ona pfupiso ye paEwing Sarcoma Mushonga.

Desmoplastic diki kutenderera sero bundu

Iko hakuna kwakajairika kurapwa kwe desmoplastic diki kutenderera sero bundu. Kurapa kunogona kusanganisira zvinotevera:

• Kuvhiya kubvisa zvachose bundu kana zvichibvira.

• Chemotherapy inoteverwa nekuvhiyiwa.

• Radiation kurapa.

• Chemotherapy uye yakanangwa kurapa (temsirolimus), yemamota anodzokororwa.

Kuwedzera-renal (extracranial) rhabdoid bundu

Kurapa kwekuwedzera-renal (extracranial) rhabdoid bundu kunogona kusanganisira zvinotevera:

• Kuvhiya kubvisa bundu pazvinogoneka.

• Chemotherapy.

• Radiation kurapa.

• Kuongororwa kwekiriniki kunoongorora muyenzaniso wemota yemurwere kune mamwe magene ekuchinja. Rudzi rwekurapa kwakanangwa kuchapihwa kumurwere kunoenderana nerudzi rwechinjo yemajini.

• Kuongororwa kwekiriniki yekurapa kwakanangwa (tazemetostat).

Perivascular epithelioid maseru mamota (PEComas)

Kurapa kweperivascular epithelioid cell tumors kunogona kusanganisira zvinotevera:

• Kuvhiya kubvisa bundu.

• Kucherechedza kunoteverwa nekuvhiyiwa.

• Targeted therapy (sirolimus), yemamota ane mamwe majini anochinja uye haakwanise kubviswa nekuvhiyiwa.

Asina kukodzera / Unclassified Sarcoma

Undifferentiated pleomorphic sarcoma / yakaipa malibrous histiocytoma (yakakwira-giredhi)

Iko hakuna kwakajairika kurapwa kweaya mamota.

Ona pfupiso yePDPQ paOsteosarcoma uye Malignant Fibrous Histiocytoma yeBone Kurapa kweruzivo nezve kurapwa kweanokuvadza fibrous histiocytoma yebhonzo

Ropa Mudziyo Mamota

Epithelioid hemangioendotheliomaoma

Kurapa kweepithelioid hemangioendotheliomaoma kunogona kusanganisira zvinotevera:

• Kucherechedza.

• Kuvhiya kubvisa bundu pazvinogoneka.

• Immunotherapy (interferon) uye yakanangwa kurapa (thalidomide, sorafenib, pazopanib, sirolimus) yemamota angangopararira.

• Chemotherapy.

• Yese hepatectomy uye chiropa chinotamisa kana bundu riri muchiropa.

• Kuongororwa kwekiriniki kweakanangwa kurapwa (trametinib).

Angiosarcoma yezvinyoro zvinyama

Kurapa kweAngiosarcoma kunogona kusanganisira zvinotevera:

• Kuvhiya kubvisa zvachose bundu.

• Mubatanidzwa wekuvhiya, chemotherapy, uye radiation radiation yeangososcomcom yakapararira.

• Targeted therapy (bevacizumab) uye chemotherapy yeangiosarcomas iyo yakatanga senge infantile hemangiomas.

• Kuongororwa kwekiriniki kwemakemotherapy pamwe kana isina yakanangwa kurapwa (pazopanib).

• Kuongororwa kwekiriniki ye immunotherapy (nivolumab uye ipilimumab).

Metastatic Yehucheche Nyama Tissue Sarcoma

Kurapa kwehucheche hunyoro sarcoma iyo yakapararira kune zvimwe zvikamu zvemuviri pakuongororwa inogona kusanganisira zvinotevera:

• Chemotherapy uye radiation radiation. Kuvhiya kunogona kuitwa kubvisa mamota akapararira kumapapu.

• Stereotactic body radiation kurapwa kwemamota akapararira kumapapu.

Nekurapwa kweakasiyana mamota mhando, ona iyo Kurapa Sarudzo dzeMwana Nyoro Nyama Tisue Sarcoma chikamu.

Kurapa Sarudzo dzeKudzokororazve uye Kufambira Mberi Kwemwana Nyoro Tisue Sarcoma

Kurapa kweanodzokororwa kana kufambira mberi kwehudiki nyoro sarcoma inogona kusanganisira zvinotevera:

• Kuvhiya kubvisa gomarara rakadzoka kwarakatanga kuumba kana iro rapararira kumapapu.

• Kuvhiya kunoteverwa nekunze kana kwemukati radiation kurapwa, kana radiation radiation isati yatopihwa.

• Kuvhiya kubvisa ruoko kana gumbo nekenza, kana radiation radiation yakange yatopihwa kare.

• Kuvhiya pamwe kana pasina chemotherapy yeinowanzoitika synovial sarcoma.

• Chemotherapy.

• Targeted Therapy (pazopanib).

• Immunotherapy (pembrolizumab).

• Stereotactic radiation radiation kurapwa kwecancer iyo yakapararira kune mamwe mativi emuviri, kunyanya mapapu.

• Kuongororwa kwekiriniki kweiyo nyowani chemotherapy regimen ine kana isina yakanangwa kurapwa (pazopanib).

• Kuongororwa kwekiriniki kunoongorora muyenzaniso wemota yemurwere kune mamwe magene ekuchinja. Rudzi rwekurapa kwakanangwa kuchapihwa kumurwere kunoenderana nerudzi rwechinjo yemajini.

Shandisa yedu kiriniki yekuyedza kutsvaga kutsvaga NCI-yakatsigirwa kenza kiriniki miedzo iri kugamuchira varwere. Unogona kutsvaga miedzo zvichibva parudzi rwecancer, zera remurwere, uye iko kunoitwa miyedzo. Ruzhinji ruzivo nezve zvekuedzwa zvekiriniki zvakare zviripo.

Kuti Udzidze Zvakawanda Pamusoro Pehucheche Nyama Tissue Sarcoma

Kuti uwane rumwe ruzivo kubva kuNational Cancer Institute nezve hudiki hunyoro tishu sarcoma, ona zvinotevera:

• Tissue Nyoro Sarcoma Peji Peji

• Computed Tomography (CT) Scans uye Cancer

• Mishonga Inotenderwa yeSoft Tissue Sarcoma

• Targeted Cancer Therapies

• MyPART - Yangu Yevacheche uye Yevakuru Rare Tumor Network

Kuti uwane rumwe ruzivo rwegomarara rehucheche uye zvimwe zvecancer zviwanikwa, ona zvinotevera:

• Nezve Kenza

• Cancers Yevacheche

• Kurapa Kutsvaga Kwevana Cancer Buda Disclaimer

• Mahedhi Ekupedzisira Ekurapwa kweKenza Yevacheche

• Vechidiki uye Vechidiki Vakuru vane Cancer

• Vana vane Cancer: Nhungamiro Yevabereki

• Kenza muVana neVachiri kuyaruka

• Stage

• Kurarama neCancer

• Mibvunzo Yekubvunza Wako Chiremba nezveCancer

• Kune Vakapona uye Vanotarisira