Types/myeloproliferative/patient/chronic-treatment-pdq

Chisingaperi Myeloproliferative Neoplasms Kurapa (®) -Patient Shanduro

General Ruzivo nezve Chisingaperi Myeloproliferative Neoplasms

PFUNGWA DZINOKOSHA

• Myeloproliferative neoplasms iboka rezvirwere umo mwongo wemapfupa unoita akawandisa masero matsvuku eropa, masero machena eropa, kana maplatelet.

• Iko kune matanhatu marudzi easingaperi myeloproliferative neoplasms.

• Kuyedza kunoongorora ropa nemwongo wemapfupa kunoshandiswa kuongorora isingagumi myeloproliferative neoplasms.

Myeloproliferative neoplasms iboka rezvirwere umo mwongo wemapfupa unoita akawandisa masero matsvuku eropa, masero machena eropa, kana maplatelet.

Kazhinji, mwongo wemapfupa unoita maseru eropa (maseru asina kukura) anova masero eropa akakura nekufamba kwenguva.

Anatomy yebhonzo. Bhonzo rinoumbwa necompact bone, spongy bone, uye mwongo wefupa. Compact bone rinoumba chikamu chekunze chepfupa. Spongy bone rinowanikwa zvakanyanya kumagumo emabhonzo uye rine mutsvuku. Bhonzo remapfupa rinowanikwa pakati pemapfupa mazhinji uye rine tsinga zhinji dzeropa. Kune mhando mbiri dzemongo wemapfupa: tsvuku uye yero. Mutsvuku mutsvuku une masero eropa anogona kuve masero matsvuku eropa, machena masero eropa, kana maplatelet. Yero mwongo inogadzirwa kazhinji yemafuta.

Sero reropa rinogona kuva myeloid stem cell kana lymphoid stem cell. Lymhoid stem cell rinova jena reropa jena. Iyo myeloid stem sero inova imwe yemhando nhatu dzemasero eropa akura:

• Masero matsvuku eropa anotakura okisijeni nezvimwe zvinhu kumatishu ese emuviri.

• Masero machena eropa anorwisa hutachiona nezvirwere.

• Maplatelet ayo anogadzira ropa kuwacha kubuda ropa.

Ropa masero kukura. Sero reropa rinopinda nematanho akati wandei kuti riite tsvuku reropa, platelet, kana chena reropa.

Mune myeloproliferative neoplasms, akawandisa maseru eropa anova rimwe kana mamwe marudzi emasero eropa. Iwo maronda anowanzo kukura zvishoma zvishoma sezvo huwandu hwerimwe masero eropa hunowedzera.

Iko kune matanhatu marudzi easingaperi myeloproliferative neoplasms.

Rudzi rwemyeloproliferative neoplasm rwakavakirwa pane kana akawandisa masero matsvuku eropa, machena masero eropa, kana maplatelet ari kugadzirwa. Dzimwe nguva muviri unoita wakawandisa kupfuura rumwe rudzi rweasero reropa, asi kazhinji mhando imwe yesero reropa inobatwa zvakanyanya kupfuura mamwe acho. Chisingaperi myeloproliferative neoplasms inosanganisira anotevera marudzi matanhatu:

• Chisingaperi myelogenous leukemia.

• Polycythemia vera.

• Primary myelofibrosis (inonziwo chisingaperi idiopathic myelofibrosis).

• Yakakosha thrombocythemia.

• Chisingaperi neutrophilic leukemia.

• Chirwere eosinophilic leukemia.

Aya marudzi anotsanangurwa pazasi. Chisingaperi myeloproliferative neoplasms dzimwe nguva inova yakaoma leukemia, umo mune akawandisa asina kujairika machena masero eropa akagadzirwa.

Kuyedza kunoongorora ropa nemwongo wemapfupa kunoshandiswa kuongorora isingagumi myeloproliferative neoplasms.

Iyi inotevera bvunzo uye maitiro anogona kushandiswa:

• Kuongorora kwemuviri uye nhoroondo yehutano: Kuongororwa kwemuviri kutarisa zviratidzo zvehutano, kusanganisira kuongorora zviratidzo zvehosha, zvakadai semapundu kana chero chinhu chinoratidzika sechisina kujairika. Nhoroondo yemaitiro ehutano hwemurwere uye kurwara kwakapfuura uye kurapwa kuchatorwawo.

• Yakazara huwandu hweropa (CBC) nemusiyano: Maitiro umo muyenzaniso weropa unodhonzwa nekuongororwa zvinotevera:

• Huwandu hwemasero matsvuku eropa nemaplatelet.

• Nhamba uye mhando yemasero machena eropa.

• Huwandu hwehemoglobin (protein inotakura oxygen) mumasero matsvuku eropa.

• Chikamu chemuenzaniso weropa chakaumbwa nemasero matsvuku eropa.

Yakazara kuverenga ropa (CBC). Ropa rinounganidzwa nekupinza tsono mutsinga uye richiita kuti ropa riyerere muhubhu. Muenzaniso weropa unotumirwa murabhoritari uye masero matsvuku eropa, masero machena eropa, uye maplatelet anoverengwa. Iyo CBC inoshandiswa kuyedza, kuongorora, uye kuongorora akawanda mamiriro akasiyana.

• Peripheral ropa smear: Maitiro umo muyenzaniso weropa unoongororwa zvinotevera:

• Kunyangwe paine masero matsvuku eropa akaumbwa semisodzi.

• Huwandu nemhando dzemasero machena eropa.

• Huwandu hwemaplatelet.

• Kunyangwe paine blast cell.

• Ropa kemesitiri zvidzidzo: Maitiro umo muyedzo weropa unoongororwa kuyera huwandu hwezvimwe zvinhu zvakaburitswa muropa nenhengo uye nyama munyama. Chinhu chisina kujairika (chakakwirira kana chakaderera pane zvakajairwa) chiyero chechinhu chinogona kunge chiri chiratidzo chechirwere.

• Bone marrow aspiration uye biopsy: Kubviswa kwemongo wefupa, ropa, uye chidimbu chefupa nekuisa tsono isina mhango muhudyu kana pfupa rechipfuva. Nyanzvi yezvirwere anoona pfupa, ropa, uye pfupa pasi pe microscope kutsvaga masero asina kujairika.

Bone marora chishuwo uye biopsy. Mushure mekunge nzvimbo diki yeganda yave nechiveve, tsono yemongo wemapfupa inoiswa mupfupa rehudyu remurwere. Samples reropa, bhonzo, uye mwongo wemapfupa zvinobviswa kuti zviongororwe pasi pe microscope.

• Kuongorora kweCytogenetic: Kuongororwa kwerabhoritari umo ma chromosomes emasero mune imwe sampu yemongo kana ropa anoverengwa uye kuongororwa chero shanduko, sekutyorwa, kushaikwa, kurongedzwa patsva, kana mamwe ma chromosomes. Shanduko mune mamwe ma chromosomes inogona kunge iri chiratidzo checancer. Kuongorora kweCytogenetic kunoshandiswa kubatsira kuongorora cancer, kuronga kurapwa, kana kuona kuti kurapa kuri kushanda sei.

• Gene shanduko bvunzo: Kuongororwa kwerabhoritari kunoitwa pamafupa kana sosi yeropa kutarisa shanduko muJAK2, MPL, kana maCALR magene. Iyo JAK2 gene mutation inowanzo kuwanikwa kune varwere vane polycythemia vera, yakakosha thrombocythemia, kana yekutanga myelofibrosis. MPL kana CALR gene shanduko inowanikwa mune varwere vane yakakosha thrombocythemia kana yekutanga myelofibrosis.

Chisingaperi Myelogenous Leukemia

Chisingaperi myelogenous leukemia chirwere umo mune akawanda machena maseru eropa akagadzirwa mupfupa remongo. Maona pfupiso ye pamusoro peMyerogenous Leukemia Kurapa kweruzivo rwekuongororwa, kuiswa, uye kurapwa.

Polycythemia Vera

PFUNGWA DZINOKOSHA

• Polycythemia vera chirwere umo masero matsvuku eropa akawandisa anogadzirwa mumongo wemapfupa.

• Zviratidzo zve polycythemia vera zvinosanganisira kutemwa nemusoro uye kunzwa kwekuzara pazasi pembabvu kuruboshwe.

• Yakakosha miedzo yeropa inoshandiswa kuongorora polycythemia vera.

Polycythemia vera chirwere umo masero matsvuku eropa akawandisa anogadzirwa mumongo wemapfupa.

Mune polycythemia vera, iro ropa rinove rakakora nemasero matsvuku eropa akawandisa. Kuwanda kwemasero machena eropa uye maplatelet anogona zvakare kuwedzera. Aya mamwe masero eropa anogona kuunganidzwa mupepa uye achikonzera kuzvimba. Iyo yakawedzera nhamba yemasero matsvuku eropa, machena masero eropa, kana maplatelet muropa anogona kukonzera matambudziko ekubuda ropa uye kuita mafweji fomu mumidziyo yeropa. Izvi zvinogona kuwedzera njodzi yesitiroko kana chirwere chemwoyo. Mune varwere vakura kupfuura makore makumi matanhatu nemashanu kana vane nhoroondo yekugwamba kweropa, njodzi yekurohwa neshuga kana chirwere chemwoyo chakakwirira. Varwere vane njodzi yakawedzera yeacute myeloid leukemia kana primary myelofibrosis.

Zviratidzo zve polycythemia vera zvinosanganisira kutemwa nemusoro uye kunzwa kwekuzara pazasi pembabvu kuruboshwe.

Polycythemia vera kazhinji haina kukonzera zviratidzo zvekutanga kana zviratidzo. Inogona kuwanikwa panguva yekuongororwa kweropa. Zviratidzo nezviratidzo zvinogona kuitika sezvo kuwanda kwemasero eropa kuchiwedzera. Dzimwe mamiriro anogona kukonzera iwo iwo iwo zviratidzo nezviratidzo. Tarisa nachiremba wako kana iwe uine chero chinotevera:

• Kunzwa kwekumanikidza kana kuzara pazasi pembabvu kuruboshwe.

• Kutemwa nemusoro.

• Kuona kaviri kana kuona rima kana bofu mavara anouya nekuenda.

• Kuvava muviri wese, kunyanya mushure mekuve mune inodziya kana inopisa mvura.

• Chiso chakatsvuka chinoratidzika kunge kutsvuka kana kupisa kwezuva.

• Kushaya simba.

• Dzungu.

• Kurera huremu pasina chikonzero chinozivikanwa.

Yakakosha miedzo yeropa inoshandiswa kuongorora polycythemia vera.

Pamusoro pekuverengera kwakazara kweropa, mapfupa ekutsvaira uye biopsy, uye cytogenetic kuongorora, serum erythropoietin test inoshandiswa kuongorora polycythemia vera. Muchiyero ichi, muyenzaniso weropa unoongororwa muyero weerythropoietin (kemikari inokurudzira masero matsvuku eropa kugadzirwa). Mu polycythemia vera, iyo erythropoietin chikamu chingave chakaderera pane zvakajairwa nekuti muviri haudi kuita mamwe masero matsvuku eropa.

Primary Myelofibrosis

PFUNGWA DZINOKOSHA

• Primary myelofibrosis chirwere icho chisina kujairika masero eropa uye tambo inovaka mukati mefupa.

• Zviratidzo zvekutanga myelofibrosis zvinosanganisira kurwadziwa pazasi pembabvu kuruboshwe uye kunzwa kuneta zvakanyanya.

• Zvimwe zvinhu zvinokanganisa kufungidzira (mukana wekupora) uye sarudzo dzekurapa kwepakutanga myelofibrosis.

Primary myelofibrosis chirwere icho chisina kujairika masero eropa uye tambo inovaka mukati mefupa.

Mongo wemapfupa unogadzirwa nematishu anogadzira masero eropa (masero matsvuku eropa, masero machena eropa, uye maplatelet) uye webhu yefibisi inotsigira izvo zvinogadzira ropa. Mukutanga myelofibrosis (inonziwo isingagumi idiopathic myelofibrosis), huwandu hwakawanda hweropa maseru masero anova masero eropa asingakure zvakanaka (kuputika). Iyo dandemutande yefibisi mukati memongo wemapfupa inova zvakare gobvu (kunge zvinyama zvitsvuku) uye inononoka kugona kweropa-kugadzira nyama kuita masero eropa. Izvi zvinokonzeresa matishu eropa-kuita masero eropa mashoma uye mashoma. Kuti uwane nhamba yakaderera yemasero eropa akagadzirwa mumwongo wemapfupa, chiropa nechiropa zvinotanga kugadzira masero eropa.

Zviratidzo zvekutanga myelofibrosis zvinosanganisira kurwadziwa pazasi pembabvu kuruboshwe uye kunzwa kuneta zvakanyanya.

Primary myelofibrosis kazhinji haina kukonzera zviratidzo zvekutanga kana zviratidzo. Inogona kuwanikwa panguva yekuongororwa kweropa. Zviratidzo nezviratidzo zvinogona kukonzerwa neyekutanga myelofibrosis kana nemamwe mamiriro. Tarisa nachiremba wako kana iwe uine chero chinotevera:

• Kunzwa kurwadziwa kana kuzara pazasi pembabvu kuruboshwe.

• Kunzwa kuzara nekukurumidza kupfuura zvakajairwa kana uchidya.

• Kunzwa kuneta chaizvo.

• Kufema kwekufema.

• Kupwanya kuri nyore kana kubuda ropa.

• Petechiae (yakati sandara, yakatsvuka, inonongedza nzvimbo pasi peganda zvinokonzerwa nekubuda ropa).

• Kupindwa nechando.

• Kunwisa usiku ziya.

• Kuonda.

Zvimwe zvinhu zvinokanganisa kufungidzira (mukana wekupora) uye sarudzo dzekurapa kwepakutanga myelofibrosis.

Kufungidzira kunoenderana nezvinotevera:

• Zera remurwere.

• Nhamba yemasero matsvuku eropa uye masero machena eropa.

• Huwandu hwekuputika muropa.

• Kunyangwe paine dzimwe shanduko muma chromosomes.

• Kunyangwe murwere aine zviratidzo zvakaita sefivha, kudiridza husiku kudikitira, kana kuonda.

Yakakosha Thrombocythemia

PFUNGWA DZINOKOSHA

• Yakakosha thrombocythemia chirwere umo maplatelet akawandisa anogadzirwa mumongo wemapfupa.

• Varwere vane yakakosha thrombocythemia vanogona kunge vasina zviratidzo kana zviratidzo.

• Zvimwe zvinhu zvinokanganisa kufungidzira (mukana wekupora) uye nzira dzekurapa dzakakosha thrombocythemia.

Yakakosha thrombocythemia chirwere umo maplatelet akawandisa anogadzirwa mumongo wemapfupa.

Yakakosha thrombocythemia inokonzeresa kusanzwisisika kuwanda kwenhamba yemaplatelet akaitwa muropa uye pfupa remongo.

Varwere vane yakakosha thrombocythemia vanogona kunge vasina zviratidzo kana zviratidzo.

Inokosha thrombocythemia kazhinji haina kukonzera zviratidzo zvekutanga kana zviratidzo. Inogona kuwanikwa panguva yekuongororwa kweropa. Zviratidzo nezviratidzo zvinogona kukonzerwa neakakosha thrombocytopenia kana nemamwe mamiriro. Tarisa nachiremba wako kana iwe uine chero chinotevera:

• Kutemwa nemusoro.

• Kutsva kana kurira mumaoko kana mutsoka.

• Kutsvuka uye kudziya kwemaoko kana tsoka.

• Kuona kana matambudziko ekunzwa.

Maplatelet anonamira. Kana paine maplatelet akawandisa, anogona kuumbana pamwe nekuomesa ropa kuyerera. Mavhinga anogona kuumba mumidziyo yeropa uye panogona zvakare kuve nekuwedzera kubuda ropa. Izvi zvinogona kukonzera matambudziko akakomba ehutano senge sitiroko kana chirwere chemwoyo.

Zvimwe zvinhu zvinokanganisa kufungidzira (mukana wekupora) uye nzira dzekurapa dzakakosha thrombocythemia.

Kufungidzira uye sarudzo dzekurapa dzinoenderana nezvinotevera:

• Zera remurwere.

• Kunyangwe murwere aine zviratidzo kana zviratidzo kana mamwe matambudziko ane chekuita neakakosha thrombocythemia.

Chisingaperi Neutrophilic Leukemia

Chisingaperi neutrophilic leukemia chirwere umo masero eropa akawandisa anova mhando yesero reropa jena rinonzi neutrophils. Neutrophils hutachiona-kurwisa masero eropa anotenderedza nekuparadza masero akafa uye zvekunze zvinhu (senge mabhakitiriya). Iyo spleen uye chiropa zvinogona kuzvimba nekuda kweyekuwedzera neutrophils. Chirwere neutrophilic leukemia inogona kuramba yakafanana kana inogona kufambira mberi nekukasira kusvika kune acute leukemia

Chisingaperi Eosinophilic Leukemia

PFUNGWA DZINOKOSHA

• Chisingaperi eosinophilic leukemia chirwere umo mune akawandisa machena masero eropa (eosinophils) anogadzirwa mumongo wemapfupa.

• Zviratidzo nezviratidzo zvechisingaperi eosinophilic leukemia zvinosanganisira kupisa muviri uye kunzwa kuneta zvakanyanya.

Chisingaperi eosinophilic leukemia chirwere umo mune akawandisa machena masero eropa (eosinophils) anogadzirwa mumongo wemapfupa.

Eosinophils machena masero eropa ayo anoita kune maorerergen (zvinhu zvinokonzeresa kugadziriswa) uye anobatsira kurwisa hutachiona hunokonzerwa nezvimwe zvipembenene. Mune chisingaperi eosinophilic leukemia, kune akawandisa eosinophil muropa, mwongo wemapfupa, uye mamwe matishu. Chirwere eosinophilic leukemia inogona kuramba yakangofanana kwemakore mazhinji kana inogona kufambira mberi nekukasira kuita acute leukemia.

Zviratidzo nezviratidzo zvechisingaperi eosinophilic leukemia zvinosanganisira kupisa muviri uye kunzwa kuneta zvakanyanya.

Chirwere eosinophilic leukemia inogona kusakonzera ekutanga zviratidzo kana zviratidzo. Inogona kuwanikwa panguva yekuongororwa kweropa. Zviratidzo nezviratidzo zvinogona kukonzerwa nechisingaperi eosinophilic leukemia kana nemamwe mamiriro. Tarisa nachiremba wako kana iwe uine chero chinotevera:

• Kupindwa nechando.

• Kunzwa kuneta chaizvo.

• Kukosora.

• Kuzvimba pasi peganda rakakomberedza maziso nemiromo, muhuro, kana pamaoko nemakumbo.

• Kutambudzika kwemhasuru.

• Itching.

• Manyoka.

Matanho eChisingaperi Myeloproliferative Neoplasms

PFUNGWA DZINOKOSHA

• Iko hakuna yakajairwa staging system yezvisingaperi myeloproliferative neoplasms.

Iko hakuna yakajairwa staging system yezvisingaperi myeloproliferative neoplasms.

Staging ndiyo nzira inoshandiswa kuziva kuti kenza yapararira zvakadii. Iko hakuna yakajairwa staging system yezvisingaperi myeloproliferative neoplasms. Kurapa kunoenderana nerudzi rweyeloproliferative neoplasm iyo murwere anayo. Izvo zvakakosha kuti uzive mhando kuitira kuronga kurapwa.

Kurapa Sarudzo Kuongorora

PFUNGWA DZINOKOSHA

• Kune akasiyana marudzi ekurapa kwevarwere vane chisingaperi myeloproliferative neoplasms.

• Mimwe gumi neimwe yemhando yekurapa inoshandiswa:

• Kurinda kumirira

• Phlebotomy

• Platelet apheresis

• Kurapa kwekuwedzera

• Chemotherapy

• Radiation kurapa

• Imwe mishonga yekurapa

• Kuvhiya

• Biologic kurapa

• Targeted kurapwa

• Yakakwira-dose chemotherapy ine stem cell yekuisa

• Mhando nyowani dzekurapa dziri kuyedzwa mumakiriniki ekuedzwa.

• Kurapa kwezvisingaperi myeloproliferative neoplasms kunogona kukonzera mhedzisiro.

• Varwere vangangoda kufunga nezve kutora chikamu mukutora kiriniki.

• Varwere vanogona kupinda mumakiriniki miedzo vasati, panguva, kana mushure mekutanga kwavo kenza kurapwa.

• Yekutevera-bvunzo inogona kudikanwa.

Kune akasiyana marudzi ekurapa kwevarwere vane chisingaperi myeloproliferative neoplasms.

Mhando dzakasiyana dzekurapa dzinowanikwa kune varwere vane chisingaperi myeloproliferative neoplasms. Mamwe marapirwo akajairwa (iko kurapwa kwazvino kwashandiswa), uye kumwe kuedzwa mumakiriniki ekuedzwa A kurapwa kiriniki kutongwa chidzidzo chekutsvaga chakaitirwa kubatsira kuvandudza marapirwo azvino kana kuwana ruzivo nezvekurapa kutsva. Kana kiriniki miedzo ikaratidza kuti kurapwa kutsva kuri nani pane kwese kurapwa, kurapwa kutsva kunogona kuve kwakajairwa kurapwa. Varwere vangangoda kufunga nezve kutora chikamu mukutora kiriniki. Mimwe miedzo yekiriniki yakavhurwa chete kune varwere vasina kutanga kurapwa.

Mimwe gumi neimwe yemhando yekurapa inoshandiswa:

Kurinda kumirira

Kurindira kumirira kuri kunyatsoongorora mamiriro emurwere pasina kupa chero kurapwa kusvikira zviratidzo kana zviratidzo zvaonekwa kana kuchinja.

Phlebotomy

Phlebotomy inzira inotorwa ropa kubva mutsinga. Muenzaniso weropa unogona kutorwa kuitira kuongororwa senge CBC kana kemisitiri yeropa. Dzimwe nguva phlebotomy inoshandiswa sekurapa uye ropa rinotorwa kubva mumuviri kubvisa mamwe masero matsvuku eropa. Phlebotomy inoshandiswa nenzira iyi kurapa mamwe asingagumi myeloproliferative neoplasms.

Platelet apheresis

Platelet apheresis kurapwa kunoshandisa muchina wakasarudzika kubvisa maplatelet muropa. Ropa rinotorwa kubva kumurwere uye rinoiswa kuburikidza neparadzanisa masero eropa panobviswa maplatelet. Ropa rasara rinobva radzoserwa muropa remurwere.

Kurapa kwekuwedzera

Transfusion therapy (kuwedzerwa ropa) inzira yekupa masero matsvuku eropa, masero machena eropa, kana maplatelet kutsiva masero eropa akaparadzwa nechirwere kana kurapwa kwegomarara.

Chemotherapy

Chemotherapy mushonga wekenza unoshandisa mishonga kumisa kukura kwemasero ekenza, kungave nekuuraya maseru kana nekuamisa iwo kubva pakupatsanuka. Kana chemotherapy ikatorwa nemuromo kana kujowa mutsinga kana mhasuru, mishonga inopinda muropa uye inogona kusvika masero emukenza mumuviri wese (systemic chemotherapy). Kana chemotherapy ikaiswa yakanangana necerebrospinal fluid, nhengo, kana dumbu remuviri senge dumbu, iwo madhiragi anonyanya kukanganisa cancer maseru munzvimbo idzodzo (remunharaunda chemotherapy). Nzira iyo chemotherapy inopihwa inoenderana nerudzi uye nhanho yekenza iri kurapwa.

Ona Zvinodhaka Zvinotenderwa zveMyeloproliferative Neoplasms kuti uwane rumwe ruzivo.

Radiation kurapa

Radiation kurapa kurapwa kenza iyo inoshandisa yakakwira-simba x-rays kana mamwe marudzi e radiation kuuraya cancer maseru kana kuachengeta iwo kuti asakure. External radiation therapy inoshandisa muchina uri kunze kwemuviri kutumira radiation kune iyo nzvimbo yemuviri nekenza.

Kunze kweradiotherapy kurapwa kunorapa chisingaperi myeloproliferative neoplasms, uye inowanzo kunangiswa kune spleen.

Imwe mishonga yekurapa

Prednisone uye danazol mishonga inogona kushandiswa kurapa kupererwa neropa muvarwere vane primary myelofibrosis.

Anagrelide therapy inoshandiswa kudzikisa njodzi yekugwamba kweropa kune varwere vane maplatelet akawanda muropa ravo. Yakaderera-dose aspirin inogona zvakare kushandiswa kudzikisa njodzi yekugwamba kweropa.

Thalidomide, lenalidomide, uye pomalidomide mishonga inodzivirira tsinga dzeropa kubva mukukura dzichienda munzvimbo dzemarara maseru.

Ona Zvinodhaka Zvinotenderwa zveMyeloproliferative Neoplasms kuti uwane rumwe ruzivo.

Kuvhiya

Splenectomy (kuvhiya kubvisa iyo spleen) inogona kuitwa kana iyo spleen yakawedzerwa.

Biologic kurapa

Biologic kurapa kurapwa kunoshandisa immune system yemurwere kurwisa gomarara kana zvimwe zvirwere. Zvinhu zvakagadzirwa nemuviri kana zvinogadzirwa murabhoritari zvinoshandiswa kusimudzira, kunongedza, kana kudzorera kudzivirira kwemuviri kuchirwere. Rudzi urwu rwekurapa runonziwo biotherapy kana immunotherapy. Interferon alfa uye pegylated interferon alpha ndeye biologic vamiririri anowanzo shandiswa kurapa mamwe asingaperi myeloproliferative neoplasms.

Erythropoietic kukura zvinhu zvakare ari biologic vamiririri. Izvo zvinoshandiswa kukurudzira mwongo wepfupa kugadzira masero matsvuku eropa.

Targeted kurapwa

Targeted therapy mhando yekurapa inoshandisa zvinodhaka kana zvimwe zvinhu kuti zvione uye kurwisa chaiwo maseru ekenza pasina kukuvadza zvakajairika maseru. Tyrosine kinase inhibitors inotarisirwa kurapa mishonga inovhara zviratidzo zvinodiwa kuti mamota akure.

Ruxolitinib ndeye tyrosine kinase inhibitor inoshandiswa kurapa polycythemia vera uye mamwe marudzi e myelofibrosis.

Ona Zvinodhaka Zvinotenderwa zveMyeloproliferative Neoplasms kuti uwane rumwe ruzivo.

Dzimwe mhando dzeanotarisirwa marapirwo ari kuongororwa mumakiriniki ekuedzwa.

Yakakwira-dose chemotherapy ine stem cell yekuisa

Yakakwira madosi ekemotherapy anopiwa kuuraya cancer maseru. Masero ane hutano, kusanganisira masero anogadzira ropa, anoparadzwa nekenza kurapwa. Stem cell transplant kurapwa kwekutsiva maseru anogadzira ropa. Masero emashizha (masero eropa asina kusimba) anobviswa muropa kana mwongo wemapfupa emurwere kana mupi uye anoomeswa nechando. Mushure mekunge murwere apedza chemotherapy, maseru akachengetwa anonyungudutswa uye ndokudzoserwa kumurwere kuburikidza nekumukiswa. Aya akadzikiswa maseru emadzinde anokura kuita (uye kudzorera) masero eropa emuviri.

Stem cell kuisirwa. (Nhanho 1): Ropa rinotorwa kubva mutsinga iri muruoko rweanopa. Murwere kana mumwe munhu angave ari mupi. Ropa rinoyerera nemuchina unobvisa masero emadzinde. Ipapo iro ropa rinodzoserwa kune anenge apa kuburikidza netsinga iri mune rumwe ruoko. (Nhanho 2): Murwere anogamuchira chemotherapy kuuraya masero anogadzira ropa. Murwere anogona kupihwa radiation radiation (isina kuratidzwa). (Nhanho 3): Murwere anogamuchira masero emadzinde kuburikidza nekateti yakaiswa mumudziyo weropa muchipfuva.

Mhando nyowani dzekurapa dziri kuyedzwa mumakiriniki ekuedzwa.

Ruzivo nezve kiriniki miedzo inowanikwa kubva kuNCI webhusaiti.

Kurapa kwezvisingaperi myeloproliferative neoplasms kunogona kukonzera mhedzisiro.

Kuti uwane ruzivo nezve mhedzisiro inokonzerwa nekurapwa kwegomarara, ona yedu Side Mhedzisiro peji.

Varwere vangangoda kufunga nezve kutora chikamu mukutora kiriniki.

Kune vamwe varwere, kutora chikamu mumuedzo wekiriniki inogona kunge iri sarudzo yekurapa yakanyanya kunaka. Kliniki miedzo chikamu chekenza tsvagiridzo. Zvemakiriniki miedzo inoitwa kuti uone kana marapirwo matsva egomarara akachengeteka uye achishanda kana zvirinani pane akajairwa kurapwa.

Mazhinji emazuva ano marapirwo akajairwa ekenza akavakirwa pamavambo emakiriniki ekuedzwa. Varwere vanotora chikamu mukuyedzwa kwekiriniki vanogona kuwana kurapwa kwakaringana kana kuve pakati pevekutanga kurapwa kutsva.

Varwere vanotora chikamu mumiedzo yekiriniki zvakare vanobatsira kugadzirisa marapirwo achaitwa kenza mune ramangwana. Kunyangwe kana miedzo yemakiriniki isinga tangire kumarapirwo matsva anoshanda, anowanzo pindura mibvunzo yakakosha uye anobatsira kufambisira mberi kutsvagurudza.

Varwere vanogona kupinda mumakiriniki miedzo vasati, panguva, kana mushure mekutanga kwavo kenza kurapwa.

Mimwe miedzo yekiriniki inosanganisira chete varwere vasati vagamuchira kurapwa. Mimwe miedzo yekuedza kurapwa kwevarwere vane kenza haina kuve nani. Kune mamwezve emakiriniki miedzo inoedza nzira nyowani dzekumisa cancer kubva kudzokororazve (kudzoka) kana kudzikisira mhedzisiro yemakenza kurapwa.

Kuedzwa kwemakiriniki kuri kuitika munzvimbo zhinji dzenyika. Ruzivo nezve kiriniki miedzo inotsigirwa neNCI inogona kuwanikwa paNCI yekiriniki miedzo yekutsvaga peji rewebhu. Kliniki miedzo inotsigirwa nemamwe masangano inogona kuwanikwa pane yeClinicalTrials.gov webhusaiti.

Yekutevera-bvunzo inogona kudikanwa.

Mimwe miedzo yakaitwa kuongorora gomarara kana kutsvaga danho rekenza inogona kudzokororwa. Dzimwe bvunzo dzinodzokororwa kuitira kuti vaone kuti kurapa kuri kushanda sei. Sarudzo nezvekuti uenderere mberi, shandura, kana kumisa kurapwa kunogona kunge kuchibva pamhedzisiro yeiyi bvunzo.

Mimwe bvunzo ichaenderera ichiitwa nguva nenguva mushure mekunge kurapwa kwapera. Mhedzisiro yeiyi bvunzo inogona kuratidza kana mamiriro ako achinja kana kana gomarara radzoka (dzoka). Iyi bvunzo dzimwe nguva inonzi yekuteedzera-bvunzo kana kuongorora-kumusoro.

Kurapa kweChirwere Myeloproliferative Neoplasms

Muchikamu chino

• Chisingaperi Myelogenous Leukemia

• Polycythemia Vera

• Primary Myelofibrosis

• Yakakosha Thrombocythemia

• Chisingaperi Neutrophilic Leukemia

• Chisingaperi Eosinophilic Leukemia

Kuti uwane ruzivo nezve marapirwo akanyorwa pazasi, ona iyo Chikamu Sarudzo Yekutarisa Chikamu.

Chisingaperi Myelogenous Leukemia

Ona pfupiso ye nezve Chisingaperi Myelogenous Leukemia Kurapa kweruzivo.

Polycythemia Vera

Chinangwa chekurapa polycythemia vera kudzora huwandu hwerimwe masero eropa. Kurapa kwepolycythemia vera kunogona kusanganisira zvinotevera:

• Phlebotomy.

• Chemotherapy ine kana isina phlebotomy. Kana iyo chemotherapy isingashande, yakanangwa kurapa (ruxolitinib) inogona kupihwa.

• Biologic kurapa uchishandisa interferon alfa kana pegylated interferon alpha.

• Asipasi-dhizaini aspirin.

Shandisa yedu kiriniki yekuyedza kutsvaga kutsvaga NCI-yakatsigirwa kenza kiriniki miedzo iri kugamuchira varwere. Unogona kutsvaga miedzo zvichibva parudzi rwecancer, zera remurwere, uye iko kunoitwa miyedzo. Ruzhinji ruzivo nezve zvekuedzwa zvekiriniki zvakare zviripo.

Primary Myelofibrosis

Kurapa kwepakutanga myelofibrosis mune varwere vasina zviratidzo kana zviratidzo zvinowanzo tarisa kumirira.

Varwere vane yekutanga myelofibrosis vanogona kuve nezviratidzo kana zviratidzo zvekushaya ropa. Anemia inowanzo kurapwa pamwe nekuisirwa maseru matsvuku eropa kubvisa zviratidzo uye nekuvandudza hupenyu hwehupenyu. Mukuwedzera, kupererwa neropa kunogona kurapwa ne:

• Erythropoietic kukura zvinhu.

• Prednisone.

• Danazol.

• Thalidomide, lenalidomide, kana pomalidomide, iine kana isina prednisone.

Kurapa kwepakutanga myelofibrosis mune varwere vane zvimwe zviratidzo kana zviratidzo zvinogona kusanganisira zvinotevera:

• Targeted therapy ne ruxolitinib.

• Chemotherapy.

• Donor stem cell yekuisa.

• Thalidomide, lenalidomide, kana pomalidomide.

• Splenectomy.

• Radiation Therapy kune iyo spleen, lymph node, kana dzimwe nzvimbo kunze kwemongo wemapfupa uko masero eropa ari kuumba.

• Biologic kurapa uchishandisa interferon alfa kana erythropoietic kukura zvinhu.

• Kuongororwa kwekiriniki kweimwe yakanangwa kurapwa mishonga.

Shandisa yedu kiriniki yekuyedza kutsvaga kutsvaga NCI-yakatsigirwa kenza kiriniki miedzo iri kugamuchira varwere. Unogona kutsvaga miedzo zvichibva parudzi rwecancer, zera remurwere, uye iko kunoitwa miyedzo. Ruzhinji ruzivo nezve zvekuedzwa zvekiriniki zvakare zviripo.

Yakakosha Thrombocythemia

Kurapa kweakakosha thrombocythemia mune varwere vari pasi pemakore makumi matanhatu vasina zviratidzo kana zviratidzo uye nhamba inogamuchirwa yeplatelet inowanzo tarisa yakamirira. Kurapa kwevamwe varwere kunogona kusanganisira zvinotevera:

• Chemotherapy.

• Anagrelide kurapwa.

• Biologic kurapa uchishandisa interferon alfa kana pegylated interferon alpha.

• Platelet apheresis.

• Kuongororwa kwekiriniki kwekurapwa kutsva.

Shandisa yedu kiriniki yekuyedza kutsvaga kutsvaga NCI-yakatsigirwa kenza kiriniki miedzo iri kugamuchira varwere. Unogona kutsvaga miedzo zvichibva parudzi rwecancer, zera remurwere, uye iko kunoitwa miyedzo. Ruzhinji ruzivo nezve zvekuedzwa zvekiriniki zvakare zviripo.

Chisingaperi Neutrophilic Leukemia

Kurapa kwechirwere chisingaperi neutrophilic leukemia kunogona kusanganisira zvinotevera:

• Anopa mapfupa ekutsvaira.

• Chemotherapy.

• Biologic kurapa uchishandisa interferon alfa.

• Kuongororwa kwekiriniki kwekurapwa kutsva.

Shandisa yedu kiriniki yekuyedza kutsvaga kutsvaga NCI-yakatsigirwa kenza kiriniki miedzo iri kugamuchira varwere. Unogona kutsvaga miedzo zvichibva parudzi rwecancer, zera remurwere, uye iko kunoitwa miyedzo. Ruzhinji ruzivo nezve zvekuedzwa zvekiriniki zvakare zviripo.

Chisingaperi Eosinophilic Leukemia

Kurapa kwechirwere chisingaperi cheeosinophilic leukemia kunogona kusanganisira zvinotevera:

• Bone marrow kuisazve.

• Biologic kurapa uchishandisa interferon alfa.

• Kuongororwa kwekiriniki kwekurapwa kutsva.

Shandisa yedu kiriniki yekuyedza kutsvaga kutsvaga NCI-yakatsigirwa kenza kiriniki miedzo iri kugamuchira varwere. Unogona kutsvaga miedzo zvichibva parudzi rwecancer, zera remurwere, uye iko kunoitwa miyedzo. Ruzhinji ruzivo nezve zvekuedzwa zvekiriniki zvakare zviripo.

Kuti Udzidze Zvakawanda Nezve Chisingaperi Myeloproliferative Neoplasms

Kuti uwane rumwe ruzivo kubva kuNational Cancer Institute nezve chisingaperi myeloproliferative neoplasms, ona zvinotevera:

• Myeloproliferative Neoplasms Peji Peji

• Zvinodhaka Zvinotenderwa zveMyeloproliferative Neoplasms

• Immunotherapy Kurapa Cancer

• Ropa-Richigadzira Stem Cell Inoshandura

• Targeted Cancer Therapies

Kuti uwane ruzivo rwekenza uye zvimwe zviwanikwa kubva kuNational Cancer Institute, ona zvinotevera:

• Nezve Kenza

• Stage

• Chemotherapy uye Iwe: Tsigiro Yevanhu Vane Kenza

• Radiation Therapy uye Iwe: Rutsigiro rweVanhu Vane Kenza

• Kurarama neCancer

• Mibvunzo Yekubvunza Wako Chiremba nezveCancer

• Kune Vakapona uye Vanotarisira