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Mycosis Fungoides (Kusanganisira Sézary Syndrome) Kurapa (®) -Patient Shanduro

General Ruzivo nezve Mycosis Fungoides (Kusanganisira Sézary Syndrome)

PFUNGWA DZINOKOSHA

• Mycosis fungoides uye Sézary syndrome hosha umo maLymphocyte (rudzi rwechena sero reropa) inova yakaipa (cancer) uye inokanganisa ganda.

• Mycosis fungoides uye Sézary syndrome marudzi eachekwa T-cell lymphoma.

• Chiratidzo che mycosis fungoides ipundu tsvuku paganda.

• MuSézary syndrome, kenza T-maseru anowanikwa muropa.

• Kuyedza kunoongorora ganda neropa kunoshandiswa kuongorora mycosis fungoides uye Sézary syndrome.

• Zvimwe zvinhu zvinokanganisa kufungidzira (mukana wekupora) uye sarudzo dzekurapa.

Mycosis fungoides uye Sézary syndrome hosha umo maLymphocyte (rudzi rwechena sero reropa) inova yakaipa (cancer) uye inokanganisa ganda.

Kazhinji, mwongo wemapfupa unogadzira maseru masero eropa (maseru asina kukura) anova masero erudzi akakura nekufamba kwenguva. Sero reropa rinogona kuva myeloid stem cell kana lymphoid stem cell. Iyo myeloid stem sero inova tsvuku sero reropa, chena ropa sero, kana platelet. A lymphoid stem cell inova lymphoblast uyezve imwe yemhando nhatu dze lymphocyte (chena masero eropa):

• B-cell lymphocyte inogadzira antibodies kubatsira kurwisa hutachiona.

• T-cell lymphocyte inobatsira B-lymphocyte kugadzira masoja anobatsira kurwisa hutachiona.

• Maseru anouraya chaiwo anorwisa cancer maseru uye hutachiona.

Ropa masero kukura. Sero reropa rinopinda nematanho akati wandei kuti riite tsvuku reropa, platelet, kana chena reropa.

Mune mycosis fungoides, T-cell lymphocyte inova cancer uye inokanganisa ganda. Kana ma lymphocyte aya achiitika muropa, anonzi maSézary masero. MuSézary syndrome, kenza T-cell lymphocyte inokanganisa ganda uye huwandu hwakawanda hweSézary masero anowanikwa muropa.

Mycosis fungoides uye Sézary syndrome marudzi eachekwa T-cell lymphoma.

Mycosis fungoides uye Sézary syndrome ndiyo miviri miviri yakajairika yekucheka T-cell lymphoma (rudzi rweiyo isiri Hodgkin lymphoma). Kuti uwane rumwe ruzivo nezve mamwe marudzi ekenza yeganda kana isiri-Hodgkin lymphoma, ona inotevera pfupiso:

• Vakuru Vasiri-Hodgkin Lymphoma Kurapa

• Ganda Ganda Kurapa

• Kurapa kweMelanoma

• Kaposi Sarcoma Kurapa

Chiratidzo che mycosis fungoides ipundu tsvuku paganda.

Mycosis fungoides inogona kupfuura nhanho dzinotevera:

• Premycotic phase: Iyo scaly, tsvuku tsvuku munzvimbo dzemuviri idzo kazhinji hadzi pachena kune zuva. Uku kupenga hakukonzere zviratidzo uye kunogona kugara kwemwedzi kana makore. Izvo zvakaoma kuongorora kuputika se mycosis fungoides panguva ino.

• Chikamu chechikamu: Mutete, mutsvuku, eczema-kunge kuputika.

• Chikamu chedombo: Mapundu madiki akasimudzwa (mapapu) kana maronda akaomarara paganda, anogona kutsvuka.

• Tumor chikamu: Tumota fomu paganda. Aya mamota anogona kukura maronda uye ganda rinogona kutapukirwa.

Tarisa nachiremba wako kana uine chimwe chezviratidzo izvi.

MuSézary syndrome, kenza T-maseru anowanikwa muropa.

Zvakare, ganda muviri wese rakatsvuka, rinotsemuka, rinosvuuka uye rinorwadza. Panogona zvakare kunge paine zvigamba, mabara, kana mamota paganda. Hazvizivikanwe kana Sézary syndrome iri fomu yepamusoro ye mycosis fungoides kana chirwere chakasiyana.

Kuyedza kunoongorora ganda neropa kunoshandiswa kuongorora mycosis fungoides uye Sézary syndrome.

Iyi inotevera bvunzo uye maitiro anogona kushandiswa:

• Kuongorora kwepanyama uye nhoroondo yehutano: Kuongorora kwemuviri kutarisa zviratidzo zvehutano, kusanganisira kuongorora zviratidzo zvehosha, zvakadai semapundu, huwandu uye mhando yemaronda eganda, kana chero chinhu chinoratidzika sechisina kujairika. Mifananidzo yeganda uye nhoroondo yehutano hwemurwere * maitiro uye zvirwere zvekare uye kurapwa kuchatorwawo.

• Pedzisa kuwanda kweropa nemusiyano: Maitiro umo muyenzaniso weropa unodhonzwa nekuongororwa zvinotevera:

• Huwandu hwemasero matsvuku eropa nemaplatelet.

• Nhamba uye mhando yemasero machena eropa.

• Huwandu hwehemoglobin (protein inotakura oxygen) mumasero matsvuku eropa.

• Chikamu chemuenzaniso weropa chakaumbwa nemasero matsvuku eropa.

Yakazara kuverenga ropa (CBC). Ropa rinounganidzwa nekupinza tsono mutsinga uye richiita kuti ropa riyerere muhubhu. Muenzaniso weropa unotumirwa murabhoritari uye masero matsvuku eropa, masero machena eropa, uye maplatelet anoverengwa. Iyo CBC inoshandiswa kuyedza, kuongorora, uye kuongorora akawanda mamiriro akasiyana.

• Sézary ropa masero kuverenga: Maitiro umo muyenzaniso weropa unoonekwa pasi pe microscope kuverenga huwandu hweSezary masero.

• HIV bvunzo: Chiyero chekuyera huwandu hweanodzivirira hutachiona hweHIV mune muyenzaniso weropa. Maantibodies anogadzirwa nemuviri kana uchinge wapindwa nechinhu chekunze. Chikamu chepamusoro chemasoja ekudzivirira Mukondombera zvinogona kureva kuti muviri watapukirwa neHIV.

• Ganda biopsy: Kubviswa kwemasero kana matukisi kuti vagone kutariswa pasi pe microscope kutarisa zviratidzo zvegomarara. Chiremba anogona kubvisa kukura kubva paganda, rinozoongororwa nachiremba. Kupfuura rimwe chete bhiopsy reganda rinogona kudikanwa kuti uongorore mycosis fungoides. Mimwe miedzo inogona kuitwa pane masero kana sampuli yemashufu inosanganisira zvinotevera:

• Immunophenotyping: Kuongororwa kwerabhoritari inoshandisa masoja ekudzivirira kenza maseru zvichibva pamhando dzemaantigen kana mamaki ari pamusoro pemasero. Uyu muedzo unoshandiswa kubatsira kuongorora chaiwo marudzi e lymphoma.

• Kuyerera cytometry: Kuongororwa kwerabhoritari kunoyera huwandu hwamasero mune imwe sampuro, muzana yemasero ehupenyu mune imwe sampuro, uye mamwe maitiro emaseru, senge saizi, chimiro, uye kuvepo kwethumba (kana zvimwe) mamaki pane sero pamusoro. Masero kubva pamuenzaniso weropa remurwere, mwongo wemapfupa, kana zvimwe zvinyama zvakasvibiswa nedhayi re fluorescent, rakaiswa mune mvura, uye ndokuzopfuura rimwe panguva kuburikidza nemwenje wechiedza. Mhedzisiro yekubvunzurudza inoenderana nekuti maseru aive akasvibiswa neiyo fluorescent dhayi anoita sei padanda rechiedza. Uyu muedzo unoshandiswa kubatsira kuongorora uye kubata mamwe marudzi ekenza, senge leukemia uye lymphoma.

• T-cell receptor (TCR) jeni rearrangement bvunzo: Kuongororwa kwerabhoritari umo masero ari mune yemuenzaniso yeropa kana yemongo wemapfupa anoongororwa kuti aone kana paine kumwe kuchinjika mumageneti anogadzira masero eT T (masero machena eropa). Kuedzwa kweizvi geni shanduko kunogona kuona kana huwandu hwakawanda hweT masero aine imwe T-cell receptor iri kugadzirwa.

Zvimwe zvinhu zvinokanganisa kufungidzira (mukana wekupora) uye sarudzo dzekurapa.

Kufungidzira uye sarudzo dzekurapa dzinoenderana nezvinotevera:

• Chikamu checancer.

• Rudzi rwechironda (zvigamba, mabara, kana mamota).

• Zera remurwere uye murume.

Mycosis fungoides uye Sézary syndrome yakaoma kurapa. Kurapa kunowanzo kurapa, kubvisa zviratidzo uye nekuvandudza hupenyu hwehupenyu. Varwere vane chirwere chepakutanga vanogona kurarama makore mazhinji.

Matanho eMycosis Fungoides (Kusanganisira Sézary Syndrome)

PFUNGWA DZINOKOSHA

• Mushure mokunge mycosis fungoides uye Sézary syndrome yaonekwa, kuongororwa kunoitwa kuti uone kana maseru ekenza apararira kubva paganda kuenda kune dzimwe nhengo dzemuviri.

• Pane nzira nhatu dzinopararira negomarara mumuviri.

• Gomarara rinogona kutapukira kubva kwarakatanga kuenda kune dzimwe nhengo dzemuviri.

• Matanho anotevera anoshandiswa kune mycosis fungoides uye Sézary syndrome:

• Chikamu I Mycosis Fungoides

• Chikamu II Mycosis Fungoides

• Chikamu chechitatu Mycosis Fungoides

• Chikamu IV Mycosis Fungoides / Sézary Syndrome

Mushure mokunge mycosis fungoides uye Sézary syndrome yaonekwa, kuongororwa kunoitwa kuti uone kana maseru ekenza apararira kubva paganda kuenda kune dzimwe nhengo dzemuviri.

Maitiro anoshandiswa kutsvaga kana gomarara rapararira kubva paganda kuenda kune dzimwe nhengo dzemuviri inonzi staging. Ruzivo rwakaunganidzwa kubva munzira yekugadzwa rinotara danho rechirwere. Izvo zvakakosha kuti uzive nhanho kuitira kuronga kurapwa.

Maitiro anotevera anogona kushandiswa mukugadzirisa matanho:

• Chest x-ray: X-ray yenhengo nemapfupa mukati mechipfuva. X-ray imhando yesimba remagetsi rinogona kupfuura nemuviri uye kupinda mufirimu, richiita mufananidzo wenzvimbo dziri mukati memuviri.

• CT scan (CAT scan): Maitiro anoita akateedzana emifananidzo yakajeka yenzvimbo dziri mukati memuviri, senge lymph node, chipfuva, dumbu, uye pelvis, zvakatorwa kubva kumakona akasiyana. Mifananidzo yacho inogadzirwa nekombuta yakabatana neiyo x-ray muchina. Dhayi inogona kuiswa jekiseni kana kumedzwa kubatsira nhengo kana zvinyama kuratidza zvakajeka. Iyi nzira inonziwo computed tomography, computerized tomography, kana komputa axial tomography.

• PET scan (positron emission tomography scan): Iyo nzira yekuwana yakaipa malonda maseru mumuviri. Chishoma che radioactive glucose (shuga) inoiswa mutsinga. Iyo PET scanner inotenderera yakatenderedza muviri uye inogadzira mufananidzo wepo glucose iri kushandiswa mumuviri. Malignant tumarara maseru anoratidza kupenya mumufananidzo nekuti anoshanda uye anotora glucose yakawanda kupfuura zvinoita maseru akajairwa.

• Lymph node biopsy: Kubviswa kwezvose kana chikamu chema lymph node. Nyanzvi yezvirwere anoona iyo lymph node tishu pasi pe microscope kutarisa masero ekenza

• Bone marrow aspiration uye biopsy: Kubviswa kwemongo wepfupa uye chidimbu chefupa nekuisa tsono isina mhango muhudyu kana pfupa rechipfuva. Nyanzvi yezvirwere anoona pfupa nemabhonzo pasi pe microscope kutsvaga zviratidzo zvecancer.

Pane nzira nhatu dzinopararira negomarara mumuviri.

Kenza inogona kupararira kuburikidza nematinji, iyo lymph system, uye neropa:

• Tishu. Kenza inopararira kubva kwayakatanga nekukura ichipinda munzvimbo dziri pedyo.

• Lymph maitiro. Kenza inopararira kubva kwayakatanga nekupinda muiyo lymph system. Kenza inofamba nemumidziyo yema lymph ichienda kune dzimwe nhengo dzemuviri.

• Ropa. Kenza inopararira kubva payakatanga nekupinda muropa. Kenza inofamba nemidzi yeropa ichienda kune dzimwe nhengo dzemuviri.

Gomarara rinogona kutapukira kubva kwarakatanga kuenda kune dzimwe nhengo dzemuviri.

Kana kenza ikapararira kune chimwe chikamu chemuviri, inonzi metastasis. Cancer maseru anotsemuka kubva kwaakatanga (iro bundu rekutanga) uye achifamba kuburikidza neye lymph system kana ropa.

Lymph maitiro. Gomarara rinopinda mu "lymph system", rinofamba nemumidziyo ye "lymph", uye rinogadzira bundu (metastatic tumor) mune chimwe chikamu chemuviri.

Ropa. Kenza inopinda muropa, inofamba nemutsinga dzeropa, yoita bundu (metastatic tumor) mune chimwe chikamu chemuviri. Iyo metastatic bundu irwo rudzi rwecancer seyakanyanya bundu. Semuenzaniso, kana mycosis fungoides ikapararira ichienda kuchiropa, masero emukenza ari muchiropa ari chaizvo mycosis fungoides masero. Hosha iyi ndeye metastatic mycosis fungoides, kwete kenza yechiropa.

Matanho anotevera anoshandiswa kune mycosis fungoides uye Sézary syndrome:

Chikamu I Mycosis Fungoides

Chikamu I chakakamurwa muzvikamu IA uye IB seinotevera:

• Chikamu IA: Zvimedu, mapepa, uye / kana mahwendefa anovhara asingasviki gumi muzana yeganda pamusoro.

• Chikamu cheB IB: Zvimedu, mapepa, uye / kana mabheji anovhara gumi muzana kana kupfuura yeganda pamusoro.

• Panogona kunge paine yakaderera nhamba yeSézary masero muropa.

Chikamu II Mycosis Fungoides

Chikamu chechipiri chakakamurwa muzvikamu IIA uye IIB seinotevera:

• Chikamu chechipiri IIA: Zvimedu, mapepa, uye / kana mabheji anovhara chero huwandu hweganda pamusoro. Lymph node haina kujairika, asi haina kenza.

• Stage IIB: Rimwe kana mamwe mamota ane 1 masentimita kana makuru anowanikwa paganda. Lymph node inogona kunge isina kujairika, asi haina kenza.

Panogona kunge paine yakaderera nhamba yeSézary masero muropa.

Chikamu chechitatu Mycosis Fungoides

Muchikamu chechitatu, makumi masere kubva muzana kana kupfuura pamusoro peganda rakatsvuka uye rinogona kunge riine zvigamba, mapepa, mabhureki kana mamota Lymph node inogona kunge isina kujairika, asi haina kenza.

Panogona kunge paine yakaderera nhamba yeSézary masero muropa.

Chikamu IV Mycosis Fungoides / Sézary Syndrome

Kana paine huwandu hwakawanda hweSézary masero muropa, chirwere chinonzi Sézary syndrome.

Chikamu IV chakakamurwa muzvikamu IVA1, IVA2, uye IVB zvinotevera:

• Stage IVA1: Zvimedu, mapapuru, mabara, kana mamota anogona kuvhara chero huwandu hweganda, uye 80% kana kupfuura yeganda pamusoro inogona kutsvuka. Iyo lymph node inogona kunge isina kujairika, asi haina kenza. Kune huwandu hwakakwira hweSézary masero muropa.

• Stage IVA2: Zvimedu, mapapuru, mabara, kana mamota anogona kuvhara chero huwandu hweganda, uye 80% kana kupfuura yeganda pamusoro inogona kutsvuka. Iyo lymph node haina kujairika, kana kenza yakaumbwa mune ma lymph node. Panogona kuve nenhamba yepamusoro yeSézary masero muropa.

• Chikamu IVB: Kenza yakapararira kune dzimwe nhengo mumuviri, senge spleen kana chiropa. Patches, papules, plaque, kana mamota anogona kuvhara chero huwandu hweganda pamusoro, uye 80% kana kupfuura yeganda pamusoro inogona kutsvuka. Iyo lymph node inogona kunge isina kujairika kana cancer. Panogona kuve nenhamba yepamusoro yeSézary masero muropa.

Kurapa Sarudzo Kuongorora

PFUNGWA DZINOKOSHA

• Kune akasiyana marudzi ekurapa kwevarwere vane mycosis fungoides uye Sézary syndrome cancer.

• Mhando nomwe dzekurapwa kwakajairika dzinoshandiswa:

• Photodynamic kurapa

• Radiation kurapa

• Chemotherapy

• Imwe mishonga yekurapa

• Immunotherapy

• Targeted kurapwa

• Yepamusoro-dhiza chemotherapy uye radiation radiation ne stem cell yekuisa

• Mhando nyowani dzekurapa dziri kuyedzwa mumakiriniki ekuedzwa.

• Kurapa kwe mycosis fungoides uye Sézary syndrome kunogona kukonzera mhedzisiro.

• Varwere vangangoda kufunga nezve kutora chikamu mukutora kiriniki.

• Varwere vanogona kupinda mumakiriniki miedzo vasati, panguva, kana mushure mekutanga kwavo kenza kurapwa.

• Yekutevera-bvunzo inogona kudikanwa.

Kune akasiyana marudzi ekurapa kwevarwere vane mycosis fungoides uye Sézary syndrome cancer.

Mhando dzakasiyana dzekurapa dzinowanikwa kune varwere vane mycosis fungoides uye Sézary syndrome. Mamwe marapirwo akajairwa (iko kurapwa kwazvino kwashandiswa), uye kumwe kuedzwa mumakiriniki ekuedzwa A kurapwa kiriniki kuyedzwa chidzidzo chekutsvaga chakaitirwa kubatsira kuvandudza marapirwo azvino kana kuwana ruzivo marapirwo matsva evarwere vane gomarara. Kana kiriniki miedzo ikaratidza kuti kurapwa kutsva kuri nani pane kwese kurapwa, kurapwa kutsva kunogona kuve kwakajairwa kurapwa. Varwere vangangoda kufunga nezve kutora chikamu mukutora kiriniki. Mimwe miedzo yekiriniki yakavhurwa chete kune varwere vasina kutanga kurapwa.

Mhando nomwe dzekurapwa kwakajairika dzinoshandiswa:

Photodynamic kurapa

Photodynamic kurapa chirwere chekenza chinoshandisa mushonga uye imwe mhando yeraser light kuuraya cancer maseru. Mushonga usingashande kusvikira waburitswa muchiedza unopinzwa mutsinga. Iyo mishonga inounganidza yakawanda mumasero ekenza kupfuura mumasero akajairwa. Kune kenza yeganda, laser mwenje inopenyerwa paganda uye mushonga unoshanda uye unouraya cancer maseru. Photodynamic kurapwa kunokonzera kukuvara kudiki kune hutano hutano. Varwere vari kurapwa Photodynamic kurapwa vanozoda kudzikamisa iyo nguva yenguva inoshandiswa muzuva. Kune marudzi akasiyana eephotodynamic kurapa:

• Mu psoralen uye ultraviolet A (PUVA) kurapwa, murwere anogamuchira mushonga unonzi psoralen uyezve ultraviolet A radiation inonangidzirwa kuganda.

• Mune extracorporeal photochemotherapy, murwere anopihwa zvinodhaka uyezve mamwe masero eropa anotorwa kubva mumuviri, oiswa pasi peiyo chaiyo ultraviolet A mwenje, ndokudzoserwa mumuviri. Extracorporeal photochemotherapy inogona kushandiswa yoga kana kusanganiswa neyeganda electron beam (TSEB) radiation radiation.

Radiation kurapa

Radiation kurapa kurapwa kenza iyo inoshandisa yakakwira-simba x-rays kana mamwe marudzi e radiation kuuraya cancer maseru kana kuachengeta iwo kuti asakure. External radiation therapy inoshandisa muchina uri kunze kwemuviri kutumira radiation kune iyo nzvimbo yemuviri nekenza. Dzimwe nguva, yakazara ganda electron danda (TSEB) radiation kurapwa inoshandiswa kurapa mycosis fungoides uye Sézary syndrome. Urwu ndirwo rudzi rwekunze kwemwaranzi kurapwa uko radiation radiation muchina inovavarira maerekitironi (zvidiki, zvisingaonekwe zvidimbu) paganda rakafukidza muviri wese. Kunze kweradiotherapy kurapwa kunogona zvakare kushandiswa senge palliative kurapa kubvisa zviratidzo uye nekuvandudza hupenyu hwehupenyu.

Ultraviolet A (UVA) radiation therapy kana ultraviolet B (UVB) radiation kurapwa kunogona kupihwa uchishandisa mwenje wakasarudzika kana laser inotungamira radiation paganda.

Chemotherapy

Chemotherapy mushonga wekenza unoshandisa mishonga kumisa kukura kwemasero ekenza, kungave nekuuraya maseru kana nekuamisa iwo kubva pakupatsanuka. Kana chemotherapy ikatorwa nemuromo kana kujowa mutsinga kana mhasuru, mishonga inopinda muropa uye inogona kusvika masero emukenza mumuviri wese (systemic chemotherapy). Dzimwe nguva iyo chemotherapy ndeyemusoro (isa paganda mukirimu, mafuta, kana mafuta).

Ona Zvinodhaka Zvinotenderwa kune Asiri-Hodgkin Lymphoma kuti uwane rumwe ruzivo. (Mycosis fungoides uye Sézary syndrome mhando dzisiri-Hodgkin lymphoma.)

Imwe mishonga yekurapa

Musoro wekorticosteroids anoshandiswa kugadzirisa ganda dzvuku, kuzvimba uye kupisa ganda. Ivo rudzi rwe steroid. Musoro wecorticosteroids anogona kunge ari mukirimu, mafuta, kana mafuta.

Retinoids, senge bexarotene, mishonga ine chekuita ne vitamini A iyo inogona kudzikisira kukura kwemamwe marudzi ekenza maseru. Iwo maitinoid anogona kutorwa nemuromo kana kuiswa paganda.

Lenalidomide mushonga unobatsira immune system kuuraya zvisina kujairika masero eropa kana maseru ekenza uye inogona kudzivirira kukura kwemitsipa yeropa mitsva inoda kukura.

Vorinostat uye romidepsin maviri eayo histone deacetylase (HDAC) inhibitors anoshandiswa kurapa mycosis fungoides uye Sézary syndrome. HDAC inhibitors inokonzeresa shanduko yemakemikari inomisa mamota maseru kubva pakupatsanuka.

Ona Zvinodhaka Zvinotenderwa kune Asiri-Hodgkin Lymphoma kuti uwane rumwe ruzivo. (Mycosis fungoides uye Sézary syndrome mhando dzisiri-Hodgkin lymphoma.)

Immunotherapy

Immunotherapy kurapwa kunoshandisa immune system yemurwere kurwisa gomarara. Zvinhu zvinogadzirwa nemuviri kana kugadzirwa murabhoritari zvinoshandiswa kusimudzira, kunongedza, kana kudzorera kudzivirira kwemuviri kurwisa kenza. Rudzi rwekurapa kenza urwu rwunonziwo biotherapy kana biologic therapy.

• Interferon: Iyi kurapwa inokanganisa kupatsanurwa kwe mycosis fungoides uye Sézary maseru uye inogona kudzora bundu kukura.

Ona Zvinodhaka Zvinotenderwa kune Asiri-Hodgkin Lymphoma kuti uwane rumwe ruzivo. (Mycosis fungoides uye Sézary syndrome mhando dzisiri-Hodgkin lymphoma.)

Targeted kurapwa

Targeted therapy mhando yekurapa inoshandisa zvinodhaka kana zvimwe zvinhu kurwisa cancer maseru. Marapirwo akanangwa anowanzo kukonzera kukuvara kushoma kune masero akajairwa kupfuura chemotherapy kana radiation radiation inoita.

• Monoclonal antibody therapy: Uku kurapa kunoshandisa antibodies akagadzirwa murabhoritari kubva kune imwechete mhando ye immune immune cell. Aya ma antibodies anokwanisa kuona zvinhu pane cancer cancer kana zvakajairika zvinhu zvinogona kubatsira gomarara maseru kukura. Masoja ekudzivirira chirwere anonamira pazvinhu uye anouraya maseru egomarara, anovharira kukura kwawo, kana kuti aachengetedze kubva pakupararira. Inogona kushandiswa yoga kana kutakura zvinodhaka, chepfu, kana zvinhu zvine radioactive zvakanangana nemasero ekenza. Monoclonal antibodies inopihwa nekumisirwa.

Mhando dze monoclonal antibodies dzinosanganisira:

• Brentuximab vedotin, iyo ine monoclonal antibody inosunga kune protein, inonzi CD30, inowanikwa kune mamwe marudzi ema lymphoma maseru. Iyo zvakare ine anticancer mushonga uyo unogona kubatsira kuuraya cancer maseru.

• Mogamulizumab, iyo ine monoclonal antibody inosunga kune protein, inonzi CCR4, inowanikwa pane mamwe marudzi ema lymphoma maseru. Inogona kuvhara protein iyi uye kubatsira immune system kuuraya cancer maseru. Iyo inoshandiswa kurapa mycosis fungoides uye Sézary syndrome iyo yakadzoka kana haina kuzova nani mushure mekurapwa neinenge imwechete systemic kurapwa.

Yepamusoro-dhiza chemotherapy uye radiation radiation ne stem cell yekuisa

Yakakwira madosi ekemotherapy uye dzimwe nguva radiation radiation inopihwa kuuraya cancer maseru. Masero ane hutano, kusanganisira masero anogadzira ropa, anoparadzwa nekenza kurapwa. Stem cell transplant kurapwa kwekutsiva maseru anogadzira ropa. Masero emashizha (masero eropa asina kusimba) anobviswa muropa kana mwongo wemapfupa emurwere kana mupi uye anoomeswa nechando. Mushure mekunge murwere apedza chemotherapy uye radiation radiation, iyo yakachengetwa masero maseru anonyungudutswa uye ndokudzoserwa kumurwere kuburikidza nekumukiswa. Aya akadzikiswa maseru emadzinde anokura kuita (uye kudzoreredza) masero eropa emuviri.

Mhando nyowani dzekurapa dziri kuyedzwa mumakiriniki ekuedzwa.

Ruzivo nezve kiriniki miedzo inowanikwa kubva kuNCI webhusaiti.

Kurapa kwe mycosis fungoides uye Sézary syndrome kunogona kukonzera mhedzisiro.

Kuti uwane ruzivo nezve mhedzisiro inokonzerwa nekurapwa kwegomarara, ona yedu Side Mhedzisiro peji.

Varwere vangangoda kufunga nezve kutora chikamu mukutora kiriniki.

Kune vamwe varwere, kutora chikamu mumuedzo wekiriniki inogona kunge iri sarudzo yekurapa yakanyanya kunaka. Kliniki miedzo chikamu chekenza tsvagiridzo. Zvemakiriniki miedzo inoitwa kuti uone kana marapirwo matsva egomarara akachengeteka uye achishanda kana zvirinani pane akajairwa kurapwa.

Mazhinji emazuva ano marapirwo akajairwa ekenza akavakirwa pamavambo emakiriniki ekuedzwa. Varwere vanotora chikamu mukuyedzwa kwekiriniki vanogona kuwana kurapwa kwakaringana kana kuve pakati pevekutanga kurapwa kutsva.

Varwere vanotora chikamu mumiedzo yekiriniki zvakare vanobatsira kugadzirisa marapirwo achaitwa kenza mune ramangwana. Kunyangwe kana miedzo yemakiriniki isinga tangire kumarapirwo matsva anoshanda, anowanzo pindura mibvunzo yakakosha uye anobatsira kufambisira mberi kutsvagurudza.

Varwere vanogona kupinda mumakiriniki miedzo vasati, panguva, kana mushure mekutanga kwavo kenza kurapwa.

Mimwe miedzo yekiriniki inosanganisira chete varwere vasati vagamuchira kurapwa. Mimwe miedzo yekuedza kurapwa kwevarwere vane kenza haina kuve nani. Kune mamwezve emakiriniki miedzo inoedza nzira nyowani dzekumisa cancer kubva kudzokororazve (kudzoka) kana kudzikisira mhedzisiro yemakenza kurapwa.

Kuedzwa kwemakiriniki kuri kuitika munzvimbo zhinji dzenyika. Ruzivo nezve kiriniki miedzo inotsigirwa neNCI inogona kuwanikwa paNCI yekiriniki miedzo yekutsvaga peji rewebhu. Kliniki miedzo inotsigirwa nemamwe masangano inogona kuwanikwa pane yeClinicalTrials.gov webhusaiti.

Yekutevera-bvunzo inogona kudikanwa.

Mimwe miedzo yakaitwa kuongorora gomarara kana kutsvaga danho rekenza inogona kudzokororwa. Dzimwe bvunzo dzinodzokororwa kuitira kuti vaone kuti kurapa kuri kushanda sei. Sarudzo nezvekuti uenderere mberi, shandura, kana kumisa kurapwa kunogona kunge kuchibva pamhedzisiro yeiyi bvunzo.

Mimwe bvunzo ichaenderera ichiitwa nguva nenguva mushure mekunge kurapwa kwapera. Mhedzisiro yeiyi bvunzo inogona kuratidza kana mamiriro ako achinja kana kana gomarara radzoka (dzoka). Iyi bvunzo dzimwe nguva inonzi yekuteedzera-bvunzo kana kuongorora-kumusoro.

Kurapa kweStage I uye Chikamu II Mycosis Fungoides

Kuti uwane ruzivo nezve marapirwo akanyorwa pazasi, ona iyo Chikamu Sarudzo Yekutarisa Chikamu.

Kurapa kwenzvimbo ichangobva kuongororwa I uye nhanho II mycosis fungoides inogona kusanganisira zvinotevera:

• Psoralen uye ultraviolet A (PUVA) radiation radiation.

• Ultraviolet B radiation kurapwa.

• Radiation kurapa ine yakazara ganda elektroni danda radiation radiation. Mune zvimwe zviitiko, kurapwa nemwaranzi kunopihwa maronda eganda, senge palliative kurapa yekudzora saizi size kubvisa zviratidzo nekuvandudza hupenyu.

• Immunotherapy yakapihwa yega kana inosanganiswa neyekurapa yakanangidzirwa paganda.

• Musoro chemotherapy.

• Systemic chemotherapy nechero kana kupfuura zvinodhaka, izvo zvinogona kusanganiswa netherapi yakanangiswa paganda.

• Imwe mishonga yekurapa (topical corticosteroids, retinoid therapy, lenalidomide, histone deacetylase inhibitors).

• Targeted therapy (brentuximab vedotin).

Shandisa yedu kiriniki yekuyedza kutsvaga kutsvaga NCI-yakatsigirwa kenza kiriniki miedzo iri kugamuchira varwere. Unogona kutsvaga miedzo zvichibva parudzi rwecancer, zera remurwere, uye iko kunoitwa miyedzo. Ruzhinji ruzivo nezve zvekuedzwa zvekiriniki zvakare zviripo.

Kurapa kweStage III uye Chikamu IV Mycosis Fungoides (Kusanganisira Sézary Syndrome)

Kuti uwane ruzivo nezve marapirwo akanyorwa pazasi, ona iyo Chikamu Sarudzo Yekutarisa Chikamu.

Kurapa kweachangobva kuongororwa danho III uye nhanho IV mycosis fungoides inosanganisira Sézary syndrome inoratidzira (kubvisa zviratidzo nekuvandudza hupenyu) uye inogona kusanganisira zvinotevera:

• Psoralen uye ultraviolet A (PUVA) radiation radiation.

• Ultraviolet B radiation kurapwa.

• Extracorporeal photochemotherapy yakapihwa yega kana inosanganiswa neyakaenzana ganda electron beam radiation kurapwa.

• Radiation kurapa ine yakazara ganda elektroni danda radiation radiation. Mune zvimwe zviitiko, kurapwa nemwaranzi kunopihwa maronda eganda, senge palliative kurapa yekudzora saizi size kubvisa zviratidzo nekuvandudza hupenyu.

• Immunotherapy yakapihwa yega kana inosanganiswa neyekurapa yakanangidzirwa paganda.

• Systemic chemotherapy nechero kana kupfuura zvinodhaka, izvo zvinogona kusanganiswa netherapi yakanangiswa paganda.

• Musoro chemotherapy.

• Imwe mishonga yekurapa (topical corticosteroids, lenalidomide, bexarotene, histone deacetylase inhibitors).

• Targeted therapy ne brentuximab vedotin.

Shandisa yedu kiriniki yekuyedza kutsvaga kutsvaga NCI-yakatsigirwa kenza kiriniki miedzo iri kugamuchira varwere. Unogona kutsvaga miedzo zvichibva parudzi rwecancer, zera remurwere, uye iko kunoitwa miyedzo. Ruzhinji ruzivo nezve zvekuedzwa zvekiriniki zvakare zviripo.

Kurapa kweRecurrent Mycosis Fungoides (Inosanganisira Sézary Syndrome)

Kuti uwane ruzivo nezve marapirwo akanyorwa pazasi, ona iyo Chikamu Sarudzo Yekutarisa Chikamu.

Kazhinji mycosis fungoides uye Sézary syndrome yakadzoka muganda kana mune zvimwe zvikamu zvemuviri mushure mekurapwa.

Kurapa kweanowanzoitika mycosis fungoides kusanganisira Sézary syndrome inogona kunge iri mukati mekuedzwa kwekiriniki uye inogona kusanganisira zvinotevera:

• Radiation kurapa ine yakazara ganda elektroni danda radiation radiation. Mune zvimwe zviitiko, kurapwa nemwaranzi kunopihwa maronda eganda senge palliative kurapa yekudzora saizi size kubvisa zviratidzo nekuvandudza hupenyu.

• Psoralen uye ultraviolet A (PUVA) kurapwa kwemwaranzi, iyo inogona kupihwa ne immunotherapy.

• Ultraviolet B mwaranzi.

• Extracorporeal photochemotherapy.

• Systemic chemotherapy neimwe kana zvimwe zvinodhaka.

• Imwe mishonga yekurapa (topical corticosteroids, retinoid therapy, lenalidomide, histone deacetylase inhibitors).

• Immunotherapy yakapihwa yega kana inosanganiswa neyekurapa yakanangidzirwa paganda.

• Yakakwira-dose chemotherapy, uye dzimwe nguva radiation radiation, ine stem cell yekuisa.

• Targeted therapy (brentuximab vedotin kana mogamulizumab).

Shandisa yedu kiriniki yekuyedza kutsvaga kutsvaga NCI-yakatsigirwa kenza kiriniki miedzo iri kugamuchira varwere. Unogona kutsvaga miedzo zvichibva parudzi rwecancer, zera remurwere, uye iko kunoitwa miyedzo. Ruzhinji ruzivo nezve zvekuedzwa zvekiriniki zvakare zviripo.

Kuti Udzidze Zvakawanda Nezve Mycosis Fungoides uye Sézary Syndrome

Kuti uwane rumwe ruzivo kubva kuNational Cancer Institute nezve mycosis fungoides uye Sézary syndrome, ona zvinotevera:

• Lymphoma Kumba Peji

• Photodynamic Therapy yeCancer

• Zvinodhaka Zvinotenderwa kune Asiri-Hodgkin Lymphoma

• Immunotherapy Kurapa Cancer

• Targeted Cancer Therapies

Kuti uwane ruzivo rwekenza uye zvimwe zviwanikwa kubva kuNational Cancer Institute, ona zvinotevera:

• Nezve Kenza

• Stage

• Chemotherapy uye Iwe: Tsigiro Yevanhu Vane Kenza

• Radiation Therapy uye Iwe: Rutsigiro rweVanhu Vane Kenza

• Kurarama neCancer

• Mibvunzo Yekubvunza Wako Chiremba nezveCancer

• Kune Vakapona uye Vanotarisira