Mhando / lymphoma / murwere / mwana-nhl-kurapwa-pdq

Yevacheche Isiri-Hodgkin Lymphoma Kurapa (®) -Patient Shanduro

Ruzivo Ruzhinji Nezvehucheche Isiri-Hodgkin Lymphoma

PFUNGWA DZINOKOSHA

• Udiki husiri-Hodgkin lymphoma chirwere umo mune yakaipa (gomarara) maseru anoumba mune lymph system.

• Mhando huru dze lymphoma iHodgkin lymphoma uye isiri Hodgkin lymphoma.

• Kune matatu makuru marudzi ehucheche asiri Hodgkin lymphoma.

• Vakakura B-cell isiri-Hodgkin lymphoma

• Lymphoblastic lymphoma

• Anaplastic yakakura sero lymphoma

• Dzimwe mhando dzisiri-Hodgkin lymphoma hazviwanzo muvana.

• Kurapa kwakapfuura kwekenza uye kuva nehutachiona hwemuviri kunokanganisa njodzi yekuve nehucheche husiri-Hodgkin lymphoma.

• Zviratidzo zvehucheche husiri-Hodgkin lymphoma zvinosanganisira matambudziko ekufema uye kuzvimba lymph node.

• Kuyedza kunoongorora muviri uye lymph system inoshandiswa kuona (tsvaga) uye kuongorora hudiki husiri-Hodgkin lymphoma.

• Bhiopsy inoitwa kuti uongorore hudiki husiri-Hodgkin lymphoma.

• Zvimwe zvinhu zvinokanganisa kufungidzira (mukana wekupora) uye sarudzo dzekurapa.

Udiki husiri-Hodgkin lymphoma chirwere umo mune yakaipa (gomarara) maseru anoumba mune lymph system.

Udiki husiri-Hodgkin lymphoma rudzi rwekenza inogadzirwa mune iyo lymph system, inova chikamu chemuviri wemuviri. Inobatsira kuchengetedza muviri kubva kuhutachiona nezvirwere.

Iyo lymph system inoumbwa neinotevera:

• Lymph: Isina ruvara, mvura yemvura inofamba kuburikidza nemidziyo ye lymph uye inotakura lymphocyte yaT uye B. MaLymphocyte imhando yeropa chena.

• Lymph midziyo: Netiweki yematepu matete anounganidza lymph kubva kumativi akasiyana emuviri oidzosera muropa.

• MaLymph node: Zvidiki, zvakaumbwa sebhinzi zvinochenesa lymph uye zvinochengeta masero eropa machena ayo anobatsira kurwisa hutachiona nezvirwere MaLymph node anowanikwa pamwe chete netiweki yemidziyo yema lymph mumuviri wese. Mapoka ema lymph node anowanikwa mumutsipa, underarm, mediastinum, dumbu, pelvis, uye kugomera.

• Spleen: Nhengo inogadzira maLymphocyte, inochengeta masero matsvuku eropa uye maLymphocyte, inozadza ropa, nekuparadza masero eropa ekare. Iyo spleen iri kuruboshwe kuruboshwe kwedumbu padyo nedumbu.

• Thymus: Nhengo umo T lymphocyte inokura uye ichiwanda. Iyo thymus iri muchipfuva kuseri kwebhonzo rechipfuva.

• Tonsils: maviri madiki mashoma emakemikari matema kumashure kwehuro. Pane imwe toni kune rumwe rutivi rwehuro.

• Bone marora: Iyo yakapfava, inopora matishu ari pakati pemamwe mapfupa, senge hudyu pfupa uye chipfuva chepamu. Masero machena eropa, masero matsvuku eropa, uye maplatelet anogadzirwa mumongo wemapfupa.

Anatomy yeiyo lymph system, inoratidza iyo lymph midziyo uye lymph nhengo dzinosanganisira lymph node, tonsils, thymus, spleen, uye mwongo wemapfupa. Lymph (clear fluid) uye maLymphocyte anofamba kuburikidza nemidziyo yema lymph uye mune ma lymph node uko ma lymphocyte anoparadza zvinokuvadza Iyo lymph inopinda muropa kuburikidza nemutsipa muhombe padyo nemoyo.

Kwete-Hodgkin lymphoma inogona kutanga muB B lymphocytes, T lymphocytes, kana masero anouraya chaiwo. MaLymphocyte anogona zvakare kuwanikwa muropa uye anotora mune ma lymph node, spleen, uye thymus.

Lymph tishu inowanikwawo mune zvimwe zvikamu zvemuviri senge mudumbu, gland yegland, huropi uye ganda.

Kwete-Hodgkin lymphoma inogona kuitika kune vese vakuru nevana. Kurapa kwevana kwakasiyana pane kurapwa kwevakuru. Ona anotevera pfupiso yeruzivo nezve kurapwa kweiyo isiri-Hodgkin lymphoma muvakuru:

• Vakuru Vasiri-Hodgkin Lymphoma

• Yekutanga CNS Lymphoma Kurapa

• Mycosis Fungoides (Kusanganisira Sezary Syndrome) Kurapa

Mhando huru dze lymphoma iHodgkin lymphoma uye isiri Hodgkin lymphoma.

Lymphomas yakakamurwa kuita maviri akajairwa marudzi: Hodgkin lymphoma uye isiri Hodgkin lymphoma. Iyi pfupiso ndeyekurapa kwehucheche husiri-Hodgkin lymphoma. Ona pfupiso ye paUdiki Hodgkin Lymphoma Kurapa kweruzivo nezve hudiki Hodgkin lymphoma.

Kune matatu makuru marudzi ehucheche asiri Hodgkin lymphoma.

Rudzi rwe lymphoma runotariswa nekutaridzika kwemasero pasi pe microscope. Iyo mitatu mikuru mikuru yehudiki isiri-Hodgkin lymphoma ndeiyi:

Vakakura B-cell isiri-Hodgkin lymphoma

Vakakura B-cell isiri-Hodgkin lymphomas inosanganisira:

• Burkitt neBurkitt-senge lymphoma / leukemia: Burkitt lymphoma uye Burkitt leukemia marudzi akasiyana echirwere chimwe chete. Burkitt lymphoma / leukemia ihasha (inokurumidza kukura) kusagadzikana kweB lymphocyte iyo inonyanya kuwanikwa muvana nevakuru vechidiki. Inogona kuumba mudumbu, mhete yaWaldeyer, machende, pfupa, mwongo wemapfupa, ganda, kana central nervous system (CNS). Burkitt leukemia inogona kutanga mune ma lymph node seBurkitt lymphoma uye ndokuzopararira kuropa nemwongo wemapfupa, kana inogona kutanga muropa nemongo wemapfupa isina kuumba mune ma lymph node kutanga.

Ose ari maviri Burkitt leukemia neBurkitt lymphoma zvakabatanidzwa nehutachiona nehutachiona hweEpstein-Barr (EBV), kunyangwe hutachiona hweEBV hunowanzoitika kune varwere muAfrica kupfuura muUnited States. Burkitt naBurkitt-vakaita lymphoma / leukemia vanoonekwa kana sampuro yetishu ichiongororwa uye imwe shanduko kune MYC gene inowanikwa.

• Inoparadzira yakakura B-cell lymphoma: Inoparadzira yakakura B-cell lymphoma ndiyo yakajairika mhando yeiyo isiri Hodgkin lymphoma. Iyo mhando yeB-cell isiri-Hodgkin lymphoma inokura nekukurumidza mune ma lymph node. Iyo spleen, chiropa, mwongo wemapfupa, kana zvimwe nhengo zvinowanzo kanganiswa. Kupararira kwakakura B-cell lymphoma kunoitika kazhinji muvachiri kuyaruka kupfuura kuvana.

• Primary mediastinal B-cell lymphoma: Rudzi rwe lymphoma inokura kubva mumasero eB mune mediastinum (iyo nzvimbo iri kuseri kwebhonzo rechipfuva). Inogona kupararira kune nhengo dziri pedyo kusanganisira mapapu uye saga rakakomberedza moyo. Inogona zvakare kupararira kune lymph node uye nhengo dziri kure kusanganisira itsvo. Muvana nevechiri kuyaruka, epakati mediastinal B-cell lymphoma inoitika kazhinji muvakuru vechidiki.

Lymphoblastic lymphoma

Lymphoblastic lymphoma rudzi rwe lymphoma iyo inonyanya kubata T-cell lymphocytes. Inowanzo fomu mu mediastinum (iyo nzvimbo iri kuseri kwebhokisi rechipfuva). Izvi zvinokonzeresa kunetseka kufema, kufema, kunetseka kumedza, kana kuzvimba kwemusoro nemutsipa. Inogona kupararira kune lymph node, bone, mwongo wemabhonzo, ganda, iyo CNS, nhengo dzemudumbu, uye dzimwe nzvimbo. Lymphoblastic lymphoma yakafanana neacute lymphoblastic leukemia (YOSE).

Anaplastic yakakura sero lymphoma

Anaplastic hombe cell lymphoma rudzi rwe lymphoma iyo inonyanya kubata T-cell lymphocyte. Iyo inowanzo kuumba mune ma lymph node, ganda, kana pfupa, uye dzimwe nguva inoumba mune yemudumbu turakiti, mapapu, nyama inovhara mapapu, uye mhasuru. Varwere vane anaplastic hombe cell lymphoma vane receptor, inonzi CD30, pamusoro pemasero eT. Muvana vazhinji, anaplastic hombe cell lymphoma inoratidzirwa neshanduko muALK geni inogadzira protein inonzi anaplastic lymphoma kinase. Nyanzvi yezvirwere inotsvaga maseru aya nemajini kuti abatsire kuongorora anaplastic hombe cell lymphoma.

Dzimwe mhando dzisiri-Hodgkin lymphoma hazviwanzo muvana.

Mamwe marudzi ehucheche asiri Hodgkin lymphoma haawanzo kuitika. Izvi zvinosanganisira:

• Chiremba-rudzi follicular lymphoma: Muvana, follicular lymphoma inowanikwa kunyanya muvanhurume. Inonyanya kuwanikwa mune imwe nzvimbo uye haina kupararira kune dzimwe nzvimbo mumuviri. Iyo inowanzo kuumba mumatoni uye lymph node mumutsipa, asi inogona zvakare kuumbika mumachende, itsvo, gastrointestinal turakiti, uye salivary gland.

• Marginal zone lymphoma: Marginal zone lymphoma rudzi rwe lymphoma iyo inowanzo kukura nekupararira zvishoma uye inowanzo kuwanikwa padanho rekutanga. Inogona kuwanikwa mune ma lymph node kana munzvimbo dziri kunze kwema lymph node. Marginal zone lymphoma inowanikwa kunze kwema lymph nodes muvana inonzi mucosa-inosanganisirwa lymphoid tishu (MALT) lymphoma. MALT inogona kuve yakabatana neHelicobacter pylori hutachiona hwematumbo uye Chlamydophila psittaci hutachiona hweiyo conjunctival membrane inoisa ziso.

• Primary central nervous system (CNS) lymphoma: Chekutanga CNS lymphoma inonyanya kushomeka muvana.

• Peripheral T-cell lymphoma: Peripheral T-cell lymphoma ine hasha (inokurumidza kukura) isiri Hodgkin lymphoma iyo inotanga mune yakakura T lymphocyte. Iyo T lymphocyte inokura mu thymus gland uye inoenda kune dzimwe nzvimbo dzeiyo lymph system, senge ma lymph node, mwongo wemabhonzo, uye spleen.

• Yakatemwa T-cell lymphoma: Yakatemwa T-cell lymphoma inotanga muganda uye inogona kukonzeresa ganda kuti riwedzere kana kugadzira bundu. Izvo zvisingawanzoitika muvana, asi zvinowanzoitika kune vechidiki uye vechidiki vakuru. Kune mhando dzakasiyana dzezvakatsemuka T-cell lymphoma, senge yakatemwa inoplastic hombe cell lymphoma, subcutaneous panniculitis-senge T-cell lymphoma, gamma-delta T-cell lymphoma, uye mycosis fungoides. Mycosis fungoides kashoma kuitika muvana nevechiri kuyaruka.

Kurapa kwakapfuura kwekenza uye kuva nehutachiona hwemuviri kunokanganisa njodzi yekuve nehucheche husiri-Hodgkin lymphoma.

Chero chipi zvacho chinowedzera njodzi yako yekuwana chirwere chinonzi njodzi chinhu. Kuva nenjodzi hazvireve kuti uchawana gomarara; kusava nenjodzi hazvireve kuti hauzobatwe negomarara. Taura nachiremba wemwana wako kana iwe uchifunga kuti mwana wako angave ari panjodzi.

Zvimwe zvinogona kuisa njodzi pahucheche husiri-Hodgkin lymphoma zvinosanganisira zvinotevera:

• Kurapa kwekare kwekenza.

• Kutapukirwa nehutachiona hweEpstein-Barr kana hutachiona hwehutachiona hwehutachiona hweHIV.

• Kuva nehutachiona husina simba mushure mekuiswa kana kubva kumishonga yakapihwa mushure mekuisazve.

• Kuve nezvirwere zvakagarwa nhaka (senge DNA yekugadzirisa kukanganisa syndromes iyo inosanganisira ataxia-telangiectasia, Nijmegen breakage syndrome, uye bumbiro remitemo mismatch yekushomeka kwekushomeka).

Kana lymphoma kana lymphoproliferative chirwere ichibatanidzwa neisina kusimba immune system kubva kune zvimwe zvakagara nhaka zvirwere, hutachiona hweHIV, kuisirwa kana mishonga yakapihwa mushure mekuisirwa, mamiriro acho anonzi lymphoproliferative chirwere chinosangana nekuzvidzivirira muviri. Mhando dzakasiyana dzechirwere che lymphoproliferative chakabatana ne immunodeficiency dzinosanganisira:

• Lymphoproliferative chirwere chinosanganisirwa neyekutanga immunodeficiency.

• HIV-inosanganisirwa isiri-Hodgkin lymphoma.

• Post-kuisirwa chirwere chinonzi lymphoproliferative chirwere.

Zviratidzo zvehucheche husiri-Hodgkin lymphoma zvinosanganisira matambudziko ekufema uye kuzvimba lymph node.

Izvi nezvimwe zviratidzo zvinogona kukonzerwa nehucheche husiri-Hodgkin lymphoma kana nemamwe mamiriro. Tarisa nachiremba kana mwana wako aine chero chinotevera:

• Kunetseka kufema.

• Kushungurudza.

• Kukosora.

• Kufema kwepamusoro-soro.

• Kuzvimba kwemusoro, mutsipa, kumusoro muviri, kana maoko.

• Dambudziko kumedza.

• Kuzvimba kusingarwadzi kwema lymph node mumutsipa, underarm, mudumbu kana kugomera.

• Bundu risingaperi kana kuzvimba mune testicle.

• Fivha pasina chikonzero chinozivikanwa.

• Kurera huremu pasina chikonzero chinozivikanwa.

• Night sweats.

Kuyedza kunoongorora muviri uye lymph system inoshandiswa kuona (tsvaga) uye kuongorora hudiki husiri-Hodgkin lymphoma.

Iyi inotevera bvunzo uye maitiro anogona kushandiswa:

• Kuongorora kwepanyama uye nhoroondo: Kuongororwa kwemuviri kutarisa zviratidzo zvehutano, kusanganisira kuongorora zviratidzo zvehosha, zvakadai semapundu kana chero chinhu chinoratidzika sechisina kujairika. Nhoroondo yemaitiro ehutano hwemurwere uye kurwara kwakapfuura uye kurapwa kuchatorwawo.

• Ropa kemisitiri zvidzidzo: Maitiro umo muyero weropa unoongororwa kuyera huwandu hwezvimwe zvinhu zvakaburitswa muropa nenhengo uye nyama munyama, zvinosanganisira maelectrolyte, lactate dehydrogenase (LDH), uric acid, ropa urea nitrogen (BUN) , creatinine, uye chiropa chinoshanda kukosha. Chinhu chisina kujairika (chakakwirira kana chakaderera pane zvakajairwa) chiyero chechinhu chinogona kunge chiri chiratidzo chechirwere.

• Chiropa basa bvunzo: Maitiro umo muyedzo weropa unoongororwa kuyera huwandu hwezvimwe zvinhu zvaburitswa muropa nechiropa. Iyo yakakwira kupfuura yakajairwa huwandu hwechinhu inogona kuve chiratidzo checancer.

• CT scan (CAT scan): Maitiro anoita akateedzana emifananidzo yakajeka yenzvimbo dziri mukati memuviri, inotorwa kubva kumakona akasiyana. Mifananidzo yacho inogadzirwa nekombuta yakabatana neiyo x-ray muchina. Dhayi inogona kuiswa jekiseni kana kumedzwa kubatsira nhengo kana zvinyama kuratidza zvakajeka. Iyi nzira inonziwo computed tomography, computerized tomography, kana komputa axial tomography.

Computed tomography (CT) scan yemudumbu. Mwana akarara patafura inotsvedza kuburikidza neCT scanner, iyo inotora mifananidzo ye x-ray yemukati medumbu.

• PET scan (positron emission tomography scan): Iyo nzira yekuwana yakaipa malonda maseru mumuviri. Chishoma che radioactive glucose (shuga) inoiswa mutsinga. Iyo PET scanner inotenderera yakatenderedza muviri uye inogadzira mufananidzo wepo glucose iri kushandiswa mumuviri. Malignant tumarara maseru anoratidza kupenya mumufananidzo nekuti anoshanda uye anotora glucose yakawanda kupfuura zvinoita maseru akajairwa. Dzimwe nguva PET scan uye CT scan zvinoitwa panguva imwe chete. Kana paine kenza, izvi zvinowedzera mukana wekuti iwanikwe.

Positron emission tomography (PET) scan. Mwana akarara patafura inotsvedza nepena scanner yePET. Musoro zororo uye tambo chena zvinobatsira mwana kunyepa zvakanyarara. Chishoma che radioactive glucose (shuga) inoiswa mutsinga yemwana, uye scanner inogadzira mufananidzo wekuti glucose irikushandiswa sei mumuviri. Cancer maseru anoratidza kupenya mumufananidzo nekuti anotora yakawanda glucose kupfuura zvakajairwa maseru.

• MRI (magnetic resonance imaging): Maitiro anoshandisa magineti, masaisai eredhiyo, uye komputa kugadzira yakateedzana mifananidzo yakajeka yenzvimbo dziri mukati memuviri. Iyi nzira inonziwo nyukireya magnetic resonance imaging (NMRI).

Magnetic resonance imaging (MRI) yedumbu. Mwana akarara patafura inotsvedza ichipinda muMRI scanner, inotora mifananidzo yemukati memuviri. Iyo padhi padumbu remwana inobatsira kujekesa mifananidzo.

• Lumbar puncture: Maitiro anoshandiswa kutora cerebrospinal fluid (CSF) kubva pamutsipa wepelinha. Izvi zvinoitwa nekuisa tsono pakati pemabhonzo maviri mumuzongoza nekupinda muCSF yakakomberedza musana uye kubvisa sampu yemvura. Muenzaniso weCSF unotariswa pasi pe microscope yezviratidzo zvekuti gomarara rapararira kuuropi uye musana. Maitiro aya anonzi zvakare LP kana musana tap.

Lumbar kubaya. Murwere akarara panzvimbo yakamonana patafura. Mushure mekunge diki nzvimbo kumucheto kumashure yave chiveve, tsono yemusana (tsono refu, nhete) inoiswa muchikamu chezasi chepamuviri mbichana kubvisa cerebrospinal fluid (CSF, inoratidzwa mublue). Mvura yacho inogona kutumirwa kurabhoritari kunoongororwa.

• Chest x-ray: X-ray yenhengo nemapfupa mukati mechipfuva. X-ray imhando yesimba remagetsi rinogona kupfuura nemuviri uye kupinda mufirimu, richiita mufananidzo wenzvimbo dziri mukati memuviri.

• Ultrasound bvunzo: Maitiro umo ma-high-energy ruzha mafungu (ultrasound) anodonhedzwa kubva mukati memukati nyama kana nhengo uye anoita maungira. Maungira anoumba mufananidzo wemuviri munyama unonzi sonogram. Mufananidzo wacho unogona kudhindwa kuti utariswe gare gare.

Abdominal ultrasound. Ultrasound transducer yakabatana nekombuta inosvinwa yakanangana neganda remudumbu. Iyo transducer inovhuvhuta masaisai ezwi kubva mukati memukati uye matishu kuti aite maungira anoita iyo sonogram (komputa mufananidzo).

Bhiopsy inoitwa kuti uongorore hudiki husiri-Hodgkin lymphoma.

Masero uye zvinyama zvinobviswa panguva yebiopsy kuitira kuti zvionekwe pasi pe microscope nachiremba wekutarisa zviratidzo zvecancer. Nekuti kurapwa kunoenderana nerudzi rweusiri-Hodgkin lymphoma, biopsy sampuli inofanira kuongororwa nachiremba wezvirwere ane ruzivo rwekuongorora hudiki husiri Hodgkin lymphoma.

Imwe yedzinotevera mhando dze biopsies dzinogona kuitwa:

• Excisional biopsy: Kubviswa kweiyo lymph node kana bundu rezvinyama.

• Incisional biopsy: Kubviswa kwechikamu chebundu, lymph node, kana sampu yeturu.

• Core biopsy: Kubviswa kwetishu kana chikamu cheiyo lymph node uchishandisa yakafara tsono.

• Fine-sindano aspiration (FNA) biopsy: Kubviswa kwetishu kana chikamu cheiyo lymph node uchishandisa nhete tsono.

Maitiro anoshandiswa kubvisa muyenzaniso wetissue anoenderana nekuti bundu riripo mumuviri:

• Bone marrow aspiration uye biopsy: Kubviswa kwemongo wepfupa uye chidimbu chefupa nekuisa tsono isina mhango muhudyu kana pfupa rechipfuva.

Bone marora chishuwo uye biopsy. Mushure mekunge nzvimbo diki yeganda yave nechiveve, tsono yemongo wemapfupa inoiswa mupfupa rehudyu remwana. Samples reropa, bhonzo, uye mwongo wemapfupa zvinobviswa kuti zviongororwe pasi pe microscope.

• Mediastinoscopy: Nzira yekuvhiya yekutarisa nhengo, zvinyama, uye lymph node pakati pemapapu enzvimbo dzisina kujairika. Kuchekwa (kucheka) kunoitwa nechepamusoro pechipfuva uye mediastinoscope inoiswa mubhokisi. Mediastinoscope chishoma, chubhu-senge chiridzwa chine mwenje uye lens yekuona. Iyo zvakare ine chishandiso chekubvisa tishu kana lymph node sampuli, inoongororwa pasi pe microscope yezviratidzo zvegomarara.

• Anterior mediastinotomy: Nzira yekuvhiya yekutarisa nhengo nemaviri mukati memapapu uye pakati pechipfuva uye nemoyo wenzvimbo dzisina kujairika. Kuchekwa (kucheka) kunoitwa padivi pechipfuva uye mediastinoscope inoiswa muchipfuva. Mediastinoscope chishoma, chubhu-senge chiridzwa chine mwenje uye lens yekuona. Iyo zvakare ine chishandiso chekubvisa tishu kana lymph node sampuli, inoongororwa pasi pe microscope yezviratidzo zvegomarara. Izvi zvinodaidzwa zvakare kuti Chamberlain maitiro.

• Thoracentesis: Kubviswa kwemvura kubva panzvimbo iri pakati pechidzitiro chechipfuva nemapapu, uchishandisa tsono. Nyanzvi yezvirwere anoona fluid ari pasi pe microscope kutsvaga maseru ekenza.

Kana gomarara rikawanikwa, bvunzo dzinotevera dzinogona kuitwa kuongorora maseru ekenza:

• Immunohistochemistry: Kuongororwa kwerabhoritari inoshandisa masoja ekudzivirira mamwe maantigen (mamaki) mune imwe sampuro yetishu yemurwere. Masoja ekudzivirira chirwere anowanzo sunganidzwa ne enzyme kana dhayi ye fluorescent. Mushure mekunge maantibodies akasunga kune yakasarudzika antigen mune yeiyo sampuli, iyo enzyme kana dhayi inoitwa, uye iyo antigen inogona kuzoonekwa pasi pe microscope. Rudzi urwu rweyedzo runoshandiswa kubatsira kuongorora gomarara uye kubatsira kutaurira imwe mhando yekenza kubva kune imwe mhando yegomarara.

• Kuyerera cytometry: Kuongororwa kwerabhoritari kunoyera huwandu hwamasero mune imwe sampuro, muzana yemasero ehupenyu mune imwe sampuro, uye mamwe maitiro emaseru, senge saizi, chimiro, uye kuvepo kwethumba (kana zvimwe) mamaki pane sero pamusoro. Masero kubva pamuenzaniso weropa remurwere, mwongo wemapfupa, kana zvimwe zvinyama zvakasvibiswa nedhayi re fluorescent, rakaiswa mune mvura, uye ndokuzopfuura rimwe panguva kuburikidza nemwenje wechiedza. Mhedzisiro yekubvunzurudza inoenderana nekuti maseru aive akasvibiswa neiyo fluorescent dhayi anoita sei padanda rechiedza. Uyu muedzo unoshandiswa kubatsira kuongorora uye kubata mamwe marudzi ekenza, senge leukemia uye lymphoma.

• Kuongorora kweCytogenetic: Kuongororwa kwerabhoritari umo ma chromosomes emaseru mune muyenzaniso weropa kana mongo wemapfupa anoverengwa uye kuongororwa chero shanduko, sekutyorwa, kushaikwa, kurongedzwa patsva, kana mamwe ma chromosomes. Shanduko mune mamwe ma chromosomes inogona kunge iri chiratidzo checancer. Kuongorora kweCytogenetic kunoshandiswa kubatsira kuongorora cancer, kuronga kurapwa, kana kuona kuti kurapa kuri kushanda sei.

• FISH (fluorescence in situ hybridization): Kuedzwa kwerabhoritari kunoshandiswa kutarisa uye kuverenga majeni kana ma chromosomes mumasero nematukisi. Zvidimbu zveDNA zvine dhayi ye fluorescent zvinogadzirwa murabhoritari uye zvinowedzerwa kune imwe sampuli yemasero emurwere kana zvinyama. Kana zvidimbu izvi zvakavezwa zveDNA zvonamatira kune mamwe mageneti kana nzvimbo dzekromosomes mumuenzaniso, dzinovhenekera kana dzatariswa pasi pefluorescent microscope. Chiyero cheFISH chinoshandiswa kubatsira kuongorora kenza uye kubatsira kuronga kurapwa.

• Immunophenotyping: Kuongororwa kwerabhoritari inoshandisa masoja ekudzivirira kenza maseru zvichibva pamhando dzemaantigen kana mamaki ari pamusoro pemasero. Uyu muedzo unoshandiswa kubatsira kuongorora chaiwo marudzi e lymphoma.

• Zvimwe zvinhu zvinokanganisa kufungidzira (mukana wekupora) uye sarudzo dzekurapa.

Kufungidzira (mukana wekupora) uye sarudzo dzekurapa dzinoenderana ne:

• Rudzi rwe lymphoma.

• Iko iko bundu riri mumuviri kana bundu rikaonekwa.

• Chikamu checancer.

• Kunyangwe paine dzimwe shanduko muma chromosomes.

• Mhando yekurapa kwekutanga.

• Kunyangwe iyo lymphoma yakapindura pakurapwa kwekutanga.

• Zera remurwere uye hutano hwese.

Matanho eUdiki Asiri-Hodgkin Lymphoma

PFUNGWA DZINOKOSHA

• Mushure mehucheche non-Hodgkin lymphoma yaonekwa, kuyedzwa kunoitwa kuti uone kana kenza maseru akapararira mukati meiyo lymph system kana kune zvimwe zvikamu zvemuviri.

• Pane nzira nhatu dzinopararira negomarara mumuviri.

• Aya matanho anotevera anoshandiswa kwehucheche husiri-Hodgkin lymphoma:

• Chikamu I

• Chikamu II

• Chikamu chechitatu

• Chikamu IV

Mushure mehucheche non-Hodgkin lymphoma yaonekwa, kuyedzwa kunoitwa kuti uone kana kenza maseru akapararira mukati meiyo lymph system kana kune zvimwe zvikamu zvemuviri.

Maitiro anoshandiswa kutsvaga kana kenza yapararira mukati meiyo lymph system kana kune zvimwe zvikamu zvemuviri inonzi staging. Mhedzisiro yemiedzo uye maitiro anoshandiswa kuongorora isiri-Hodgkin lymphoma inogona zvakare kushandiswa pakuratidzira. Ona iyo General Ruzivo chikamu kune tsananguro yeaya mabvunzo uye maitiro. Ruzivo rwakaunganidzwa kubva munzira yekugadzwa rinotara danho rechirwere. Izvo zvakakosha kuti uzive nhanho kuitira kuronga kurapwa.

Iyi inotevera maitiro inogona kushandiswa kuona danho.

• Bone scan: Maitiro ekutarisa kana paine nekukurumidza kupatsanura masero, senge kenza maseru, mupfupa. Chinhu chidiki kwazvo che radioactive chakabayiwa mutsinga uye chinofamba neropa. Iyo radioactive zvinhu inounganidza mumapfupa nekenza uye inoonekwa ne scanner.

Pane nzira nhatu dzinopararira negomarara mumuviri.

Kenza inogona kupararira kuburikidza nematinji, iyo lymph system, uye neropa:

• Tishu. Kenza inopararira kubva kwayakatanga nekukura ichipinda munzvimbo dziri pedyo.

• Lymph maitiro. Kenza inopararira kubva kwayakatanga nekupinda muiyo lymph system. Kenza inofamba nemumidziyo yema lymph ichienda kune dzimwe nhengo dzemuviri.

• Ropa. Kenza inopararira kubva payakatanga nekupinda muropa. Kenza inofamba nemidzi yeropa ichienda kune dzimwe nhengo dzemuviri.

Aya matanho anotevera anoshandiswa kwehucheche husiri-Hodgkin lymphoma:

Chikamu I

Chikamu I hudiki husiri-Hodgkin lymphoma. Gomarara rinowanikwa mune rimwe boka rema lymph node kana imwe nzvimbo iri kunze kwema lymph node, asi hapana kenza inowanikwa mudumbu kana mediastinum (nzvimbo iri pakati pemapapu).

Muchikamu ini hudiki husiri-Hodgkin lymphoma, kenza inowanikwa:

• mune rimwe boka rema lymph nodes; kana

• mune imwe nzvimbo iri kunze kwema lymph nodes.

Hapana kenza inowanikwa mudumbu kana mediastinum (nzvimbo iri pakati pemapapu).

Chikamu II

Stage II yehucheche isiri-Hodgkin lymphoma. Gomarara rinowanikwa mune imwe nharaunda kunze kwenzwi uye mune mamwe ma "lymph node" ari pedyo; kana munzvimbo mbiri kana kupfuura pamusoro (b) kana pazasi (c) diaphragm; kana gomarara rakatanga mudumbu, appendikisi, kana ura (d) uye rinogona kubviswa nekuvhiyiwa.

Muchikamu chechipiri chehucheche husiri Hodgkin lymphoma, kenza inowanikwa:

• mune imwe nzvimbo iri kunze kwenzvimbo dzinonzi dzi "lymph nodes" uye "lymph" node dziri pedyo. kana

• munzvimbo mbiri kana dzakapfuura pamusoro kana pazasi peya diaphragm, uye inogona kunge yakapararira kune ma lymph node ari pedyo; kana

• kutanga mudumbu kana mumatumbu uye inogona kubviswa zvachose nekuvhiyiwa. Kenza inogona kunge yakapararira kune mamwe ma lymph node ari padyo.

Chikamu chechitatu

Stage III yehucheche isiri-Hodgkin lymphoma. Gomarara rinowanikwa mune imwechete nzvimbo pamusoro uye pazasi pechirebvu (a); kana gomarara rakatanga muchipfuva (b); kana gomarara rakatanga mudumbu rikapararira mudumbu (c); kana munzvimbo yakatenderedza musana (isina kuratidzwa).

Muchikamu chechitatu chehucheche husiri Hodgkin lymphoma, kenza inowanikwa:

• mune imwechete nharaunda pamusoro peya diaphragm uye mune imwe nharaunda iri pasi pe diaphragm; kana

• kuti atange mubhokisi; kana

• kutanga mudumbu nekupararira mudumbu rese; kana

• munzvimbo yakatenderedza musana.

Chikamu IV

Stage IV yehucheche isiri-Hodgkin lymphoma. Gomarara rinowanikwa mumwongo wemapfupa, huropi, kana cerebrospinal fluid (CSF). Gomarara rinogona kuwanikwawo mune dzimwe nhengo dzemuviri.

Muchikamu IV wehucheche husiri-Hodgkin lymphoma, gomarara rinowanikwa mumwongo wemapfupa, huropi, kana cerebrospinal fluid. Gomarara rinogona kuwanikwawo mune dzimwe nhengo dzemuviri.

Dzokororo Yehucheche Isiri-Hodgkin Lymphoma

Kudzokorora kwehucheche husiri-Hodgkin lymphoma kenza yakadzokazve (kudzoka) mushure mekurapwa. Udiki husiri-Hodgkin lymphoma hunogona kudzoka muiyo lymph system kana mune zvimwe zvikamu zvemuviri.

Kurapa Sarudzo Kuongorora

PFUNGWA DZINOKOSHA

• Kune mhando dzakasiyana dzekurapa kwevana vasina-Hodgkin lymphoma.

• Vana vasina-Hodgkin lymphoma vanofanirwa kurapwa kurapwa nechikwata chevanachiremba vanova nyanzvi pakurapa gomarara rehucheche.

• Kurapa kwehucheche husiri-Hodgkin lymphoma kunogona kukonzera mhedzisiro.

• Mhando nhanhatu dzekurapwa kwakajairika dzinoshandiswa:

• Chemotherapy

• Radiation kurapa

• Yakakwira-dose chemotherapy ine stem cell yekuisa

• Targeted kurapwa

• Imwe mishonga yekurapa

• Phototherapy

• Mhando nyowani dzekurapa dziri kuyedzwa mumakiriniki ekuedzwa.

• Immunotherapy

• Varwere vangangoda kufunga nezve kutora chikamu mukutora kiriniki.

• Varwere vanogona kupinda mumakiriniki miedzo vasati, panguva, kana mushure mekutanga kwavo kenza kurapwa.

• Yekutevera-bvunzo inogona kudikanwa.

Kune mhando dzakasiyana dzekurapa kwevana vasina-Hodgkin lymphoma.

Mhando dzakasiyana dzekurapa dzinowanikwa kune vana vasina-Hodgkin lymphoma. Mamwe marapirwo akajairwa (iko kurapwa kwazvino kwashandiswa), uye kumwe kuedzwa mumakiriniki ekuedzwa A kurapwa kiriniki kuyedzwa chidzidzo chekutsvaga chakaitirwa kubatsira kuvandudza marapirwo azvino kana kuwana ruzivo marapirwo matsva evarwere vane gomarara. Kana kiriniki miedzo ikaratidza kuti kurapwa kutsva kuri nani pane kwese kurapwa, kurapwa kutsva kunogona kuve kwakajairwa kurapwa.

Kutora chikamu mukuedzwa kwekiriniki kunofanirwa kutariswa kune vese vana vasina-Hodgkin lymphoma. Mimwe miedzo yekiriniki yakavhurwa chete kune varwere vasina kutanga kurapwa.

Vana vasina-Hodgkin lymphoma vanofanirwa kurapwa kurapwa nechikwata chevanachiremba vanova nyanzvi pakurapa gomarara rehucheche.

Kurapa kunozoonekwa nachiremba wevana oncologist, chiremba ane hunyanzvi hwekurapa vana vane gomarara. Vanachiremba oncologist vanoshanda nevamwe vatapi vezvehutano vari nyanzvi mukurapa vana vasina-Hodgkin lymphoma uye vanoziva mune dzimwe nzvimbo dzemishonga. Izvi zvinogona kusanganisira vanachiremba vanotevera:

• Chiremba wevana.

• Radiation oncologist.

• Chiremba wehematologist.

• Chiremba wechiremba wechiremba.

• Mukoti wechiremba nyanzvi.

• Rehabilitation nyanzvi.

• Nyanzvi yezvepfungwa.

• Wezvemagariro.

Kurapa kwehucheche husiri-Hodgkin lymphoma kunogona kukonzera mhedzisiro.

kuti uwane ruzivo nezve mhedzisiro inotanga panguva yekurapa kenza, ona yedu Side Mhedzisiro peji.

Zvimwe zvinokonzeresa kubva pakurapwa nekenza zvinotanga mushure mekurapwa uye kuenderera kwemwedzi kana makore zvinonzi kunonoka kuitika Mhedzisiro mhedzisiro yekurapwa nekenza inogona kusanganisira zvinotevera:

• Zvinetso zvepanyama.

• Shanduko mumanzwiro, manzwiro, kufunga, kudzidza, kana ndangariro.

• Gomarara repiri (mhando nyowani dzekenza).

Mimwe mhedzisiro mhedzisiro inogona kurapwa kana kudzorwa. Izvo zvakakosha kuti utaure navanachiremba vemwana wako nezve mhedzisiro yekurapwa nekenza kunogona kuve pamwana wako. (Ona pfupiso ye paMagumo Ekurapa kweKenza Yevacheche kuti uwane rumwe ruzivo.)

Mhando nhanhatu dzekurapwa kwakajairika dzinoshandiswa:

Chemotherapy

Chemotherapy mushonga wekenza unoshandisa mishonga kumisa kukura kwemasero ekenza, kungave nekuuraya maseru kana nekuamisa iwo kubva pakupatsanuka. Kana chemotherapy ikatorwa nemuromo kana kujowa mutsinga kana mhasuru, mishonga inopinda muropa uye inogona kusvika masero emukenza mumuviri wese (systemic chemotherapy). Kana chemotherapy ikaiswa yakananga mucerebrospinal fluid (intrathecal chemotherapy), nhengo, kana muviri mhasuru senge dumbu, mishonga inonyanya kukanganisa maseru ekenza munzvimbo idzodzo. Kubatanidzwa chemotherapy kurapwa kunoshandisa maviri kana anopfuura anticancer zvinodhaka.

Nzira iyo chemotherapy inopihwa inoenderana nerudzi uye nhanho yekenza iri kurapwa.

Intrathecal chemotherapy inogona kushandiswa kurapa hudiki husiri-Hodgkin lymphoma iyo yakapararira, kana inogona kupararira, kuuropi. Kana ikashandiswa kudzikisa mukana mukana kenza inopararira kuuropi, inonzi CNS prophylaxis. Intrathecal chemotherapy inopihwa mukuwedzera kune chemotherapy nemuromo kana mutsinga. Yakakwirira kupfuura yakajairwa doses yekemotherapy inogona zvakare kushandiswa seCNS prophylaxis.

Intrathecal chemotherapy. Anticancer zvinodhaka zvinopinda mukati meiyo intrathecal nzvimbo, inova iyo nzvimbo inobata iyo cerebrospinal fluid (CSF, inoratidzwa mublue). Pane nzira mbiri dzakasiyana dzekuita izvi. Imwe nzira, inoratidzwa muchikamu chepamusoro chemufananidzo, kuisa majekiseni mumugodhi weOmaya (mudziyo wakaita sedome wakaiswa pasi peganda panguva yekuvhiyiwa; inobata mishonga painenge ichiyerera nepombi diki ichienda muuropi ). Imwe nzira, inoratidzwa muchikamu chepazasi chemufananidzo, kupinza mishonga yakananga muCSF muchikamu chepazasi chechipenga chemusana, mushure mekunge nzvimbo diki kumusana wezasi yave nechiveve.

Ona Zvinodhaka Zvinotenderwa kune Asiri-Hodgkin Lymphoma kuti uwane rumwe ruzivo.

Radiation kurapa

Radiation kurapa chirwere chekenza chinoshandisa simba rakawanda x-rays kana mamwe marudzi emwaranzi kuuraya cancer maseru kana kuachengetedza kuti asakura. Kune mhando mbiri dze radiation radiation:

• External radiation therapy inoshandisa muchina uri kunze kwemuviri kutumira radiation kune kenza.

• Yemukati radiation kurapwa kunoshandisa radioactive chinhu chakavharirwa mune tsono, mhodzi, waya, kana makateti anoiswa akananga mukati kana padyo nekenza.

Maitiro ekurapwa nemwaranzi anoenderana nerudzi rweiyo isiri Hodgkin lymphoma iri kurapwa External radiation therapy inogona kushandiswa kurapa hudiki husiri-Hodgkin lymphoma iyo yakapararira, kana inogona kupararira, kuuropi nemuzongoza. Yemukati radiation kurapwa haina kushandiswa kurapa isiri-Hodgkin lymphoma.

Yakakwira-dose chemotherapy ine stem cell yekuisa

Yakakwira madosi ekemotherapy anopiwa kuuraya cancer maseru. Masero ane hutano, kusanganisira masero anogadzira ropa, anoparadzwa nekenza kurapwa. Stem cell transplant kurapwa kwekutsiva maseru anogadzira ropa. Masero emashizha (masero eropa asina kusimba) anobviswa muropa kana mwongo wemapfupa emurwere kana mupi uye anoomeswa nechando. Mushure mekunge murwere apedza chemotherapy, maseru akachengetwa anonyungudutswa uye ndokudzoserwa kumurwere kuburikidza nekumukiswa. Aya akadzikiswa maseru emadzinde anokura kuita (uye kudzoreredza) masero eropa emuviri.

Ona Zvinodhaka Zvinotenderwa kune Asiri-Hodgkin Lymphoma kuti uwane rumwe ruzivo.

Stem cell kuisirwa. (Nhanho 1): Ropa rinotorwa kubva mutsinga iri muruoko rweanopa. Murwere kana mumwe munhu angave ari mupi. Ropa rinoyerera nemuchina unobvisa masero emadzinde. Ipapo iro ropa rinodzoserwa kune anenge apa kuburikidza netsinga iri mune rumwe ruoko. (Nhanho 2): Murwere anogamuchira chemotherapy kuuraya masero anogadzira ropa. Murwere anogona kupihwa radiation radiation (isina kuratidzwa). (Nhanho 3): Murwere anogamuchira masero emadzinde kuburikidza nekateti yakaiswa mumudziyo weropa muchipfuva.

Targeted kurapwa

Targeted therapy mhando yekurapa inoshandisa zvinodhaka kana zvimwe zvinhu kuti zvione uye kurwisa chaiwo maseru ekenza pasina kukuvadza zvakajairika maseru. Monoclonal antibodies, tyrosine kinase inhibitors, uye immunotoxins marudzi matatu eanotarisirwa kurapwa ari kushandiswa kana kudzidza mukurapa kwehucheche husiri-Hodgkin lymphoma.

Monoclonal antibody therapy ndeye kenza kurapa iyo inoshandisa antibodies inogadzirwa murabhoritari kubva kune imwechete mhando ye immune immune cell. Aya ma antibodies anokwanisa kuona zvinhu pane cancer cancer kana zvakajairika zvinhu zvinogona kubatsira gomarara maseru kukura. Masoja ekudzivirira chirwere anonamira pazvinhu uye anouraya maseru egomarara, anovharira kukura kwawo, kana kuti aachengetedze kubva pakupararira. Monoclonal antibodies inopihwa nekumisirwa. Inogona kushandiswa yoga kana kutakura zvinodhaka, chepfu, kana zvinhu zvine radioactive zvakanangana nemasero ekenza.

• Rituximab inoshandiswa kurapa akati wandei marudzi ehucheche husiri-Hodgkin lymphoma.

• Pembrolizumab inoshandiswa kurapa yekutanga mediastinal yakakura B-cell lymphoma iyo isina kupindura kurapwa kana kudzokazve (kudzoka) mushure mekurapwa neimwe kurapwa. Kurapa ne pembrolizumab kwave kunyanya kuongororwa muvakuru.

• Brentuximab vedotin inorwisa monoclonal antibody inosanganiswa neanticancer mushonga unoshandiswa kurapa anaplastic hombe cell lymphoma.

Bispecific monoclonal antibody inoumbwa nemaviri akasiyana monoclonal antibodies anosunga kune maviri akasiyana zvinhu uye anouraya cancer maseru. Bispecific monoclonal antibody therapy inoshandiswa pakurapa Burkitt neBurkitt-senge lymphoma / leukemia uye inopararira yakakura B-cell lymphoma.

Tyrosine kinase inhibitors (TKIs) anovharira masigns kuti mamota anoda kukura. Mamwe maTKI zvakare anochengetedza mamota kubva mukukura nekudzivirira kukura kwemitsipa yeropa itsva kumamota. Dzimwe mhando dze kinase inhibitors, senge crizotinib, dziri kudzidziswa kwehucheche husiri-Hodgkin lymphoma.

Immunotoxins inogona kusunga kune cancer maseru uye kuuraya iwo. Denileukin diftitox inonzi immunotoxin inoshandiswa kurapa cutaneous T-cell lymphoma.

Targeted Therapis iri kudzidziswa yekurapa kwehucheche husiri-Hodgkin lymphoma iyo yadzokazve (kudzoka).

Ona Zvinodhaka Zvinotenderwa kune Asiri-Hodgkin Lymphoma kuti uwane rumwe ruzivo.

Imwe mishonga yekurapa

Retinoids mishonga ine chekuita nevhitamini A. Retinoid kurapa nebexarotene inoshandiswa kurapa akati wandei emhando dzeT-cell lymphoma.

Steroid mahormone akagadzirwa zvakasikwa mumuviri. Izvo zvinogona zvakare kugadzirwa murabhoritari uye kushandiswa semishonga. Steroid therapy inoshandiswa kurapa akacheka T-cell lymphoma.

Phototherapy

Phototherapy kurapwa kwekenza iyo inoshandisa mushonga uye imwe mhando yeraser light kuuraya cancer maseru. Mushonga usingashande kusvikira waburitswa muchiedza unopinzwa mutsinga. Iyo mishonga inounganidza yakawanda mumasero ekenza kupfuura mumasero akajairwa. Kune kenza yeganda paganda, laser mwenje unopenyerwa paganda uye mushonga unoshanda uye unouraya cancer maseru. Phototherapy inoshandiswa pakurapa kwakatemwa T-cell lymphoma.

Mhando nyowani dzekurapa dziri kuyedzwa mumakiriniki ekuedzwa.

Ichi chidimbu chikamu chinotsanangura kurapwa kuri kuongororwa mumakiriniki ekuedzwa. Zvinogona kusataura nezveese marapirwo matsva ari kuongororwa. Ruzivo nezve kiriniki miedzo inowanikwa kubva kuNCI webhusaiti.

Immunotherapy

Immunotherapy kurapwa kunoshandisa immune system yemurwere kurwisa gomarara. Zvinhu zvinogadzirwa nemuviri kana kugadzirwa murabhoritari zvinoshandiswa kusimudzira, kunongedza, kana kudzorera kudzivirira kwemuviri kurwisa kenza. Rudzi rwekurapa kenza urwu rwunonziwo biotherapy kana biologic therapy.

Epstein-Barr hutachiona (EBV) - yakatarwa cytotoxic T-lymphocyte rudzi rwema immune maseru anogona kuuraya mamwe maseru, anosanganisira ekunze maseru, cancer maseru, uye maseru ane hutachiona hweEBV. MaCytotoxic T-lymphocyte anogona kupatsanurwa kubva kune mamwe masero eropa, akakura murabhoritari, ndokuzopihwa kumurwere kuti auraye masero egomarara. EBV-yakatarwa cytotoxic T-lymphocyte iri kuongororwa kuti irape post-transplant lymphoproliferative chirwere.

Varwere vangangoda kufunga nezve kutora chikamu mukutora kiriniki.

Kune vamwe varwere, kutora chikamu mumuedzo wekiriniki inogona kunge iri sarudzo yekurapa yakanyanya kunaka. Kliniki miedzo chikamu chekenza tsvagiridzo. Zvemakiriniki miedzo inoitwa kuti uone kana marapirwo matsva egomarara akachengeteka uye achishanda kana zvirinani pane akajairwa kurapwa.

Mazhinji emazuva ano marapirwo akajairwa ekenza akavakirwa pamavambo emakiriniki ekuedzwa. Varwere vanotora chikamu mukuyedzwa kwekiriniki vanogona kuwana kurapwa kwakaringana kana kuve pakati pevekutanga kurapwa kutsva.

Varwere vanotora chikamu mumiedzo yekiriniki zvakare vanobatsira kugadzirisa marapirwo achaitwa kenza mune ramangwana. Kunyangwe kana miedzo yemakiriniki isinga tangire kumarapirwo matsva anoshanda, anowanzo pindura mibvunzo yakakosha uye anobatsira kufambisira mberi kutsvagurudza.

Varwere vanogona kupinda mumakiriniki miedzo vasati, panguva, kana mushure mekutanga kwavo kenza kurapwa.

Mimwe miedzo yekiriniki inosanganisira chete varwere vasati vagamuchira kurapwa. Mimwe miedzo yekuedza kurapwa kwevarwere vane kenza haina kuve nani. Kune mamwezve emakiriniki miedzo inoedza nzira nyowani dzekumisa cancer kubva kudzokororazve (kudzoka) kana kudzikisira mhedzisiro yemakenza kurapwa.

Kuedzwa kwemakiriniki kuri kuitika munzvimbo zhinji dzenyika. Ruzivo nezve kiriniki miedzo inotsigirwa neNCI inogona kuwanikwa paNCI yekiriniki miedzo yekutsvaga peji rewebhu. Kliniki miedzo inotsigirwa nemamwe masangano inogona kuwanikwa pane yeClinicalTrials.gov webhusaiti.

Yekutevera-bvunzo inogona kudikanwa.

Mimwe miedzo yakaitwa kuongorora gomarara kana kutsvaga danho rekenza inogona kudzokororwa. Dzimwe bvunzo dzinodzokororwa kuitira kuti vaone kuti kurapa kuri kushanda sei. Sarudzo nezvekuti uenderere mberi, shandura, kana kumisa kurapwa kunogona kunge kuchibva pamhedzisiro yeiyi bvunzo.

Mimwe bvunzo ichaenderera ichiitwa nguva nenguva mushure mekunge kurapwa kwapera. Mhedzisiro yeiyi bvunzo inogona kuratidza kana mamiriro emwana wako achinja kana kana gomarara radzoka (dzoka). Iyi bvunzo dzimwe nguva inonzi yekuteedzera-bvunzo kana kuongorora-kumusoro.

Kurapa Sarudzo dzeMwana Asiri-Hodgkin Lymphoma

Muchikamu chino

• Burkitt uye Burkitt-kufanana lymphoma / leukemia

• Kurapa sarudzo dzeanenge achangobva kuongororwa Burkitt neBurkitt-senge lymphoma / leukemia

• Kurapa sarudzo dzekudzokorora Burkitt uye Burkitt-senge lymphoma / leukemia

• Kuparadzira yakakura B-cell lymphoma

• Kurapa sarudzo kune ichangobva kuongororwa inoparadzira yakakura B-cell lymphoma

• Kurapa sarudzo dzekudzokorora dzinoparadzira yakakura B-cell lymphoma

• Yekutanga Mediastinal B-cell Lymphoma

• Kurapa sarudzo kune ichangobva kuongororwa yepakati mediastinal B-cell lymphoma

• Kurapa sarudzo dzekudzokorora kwepakati pemasikati B-cell lymphoma

• Lymphoblastic Lymphoma

• Kurapa sarudzo kune ichangobva kuongororwa lymphoblastic lymphoma

• Kurapa sarudzo dzekudzokorora lymphoblastic lymphoma

• Anaplastic Makuru Cell Lymphoma

• Kurapa sarudzo dzeachangobva kuongororwa anaplastic hombe cell lymphoma

• Kurapa sarudzo dzekudzokororwa anaplastic hombe cell lymphoma

• Lymphoproliferative Hosha Yakabatana Nekuzvidzivirira Kwemuviri muVana

• Kurapa sarudzo ye lymphoproliferative chirwere chinosanganisirwa neyekutanga immunodeficiency

• Kurapa sarudzo kune asiri-Hodgkin lymphoma inosanganisirwa neDNA kugadzirisa kukanganisa syndromes

• Kurapa sarudzo yeHIV-inosanganisirwa isiri-Hodgkin lymphoma

• Kurapa sarudzo dzepashure-yekuisa lymphoproliferative chirwere

• Kazhinji NHL Inoitika muVana

• Kurapa sarudzo dzevana-rudzi follicular lymphoma

• Kurapa sarudzo dze marginal zone lymphoma

• Kurapa sarudzo kwekutanga CNS lymphoma

• Kurapa nzira dzeparutivi T-cell lymphoma

• Kurapa sarudzo dzechetechete T-cell lymphoma

Kuti uwane ruzivo nezve marapirwo akanyorwa pazasi, ona iyo Chikamu Sarudzo Yekutarisa Chikamu.

Burkitt uye Burkitt-kufanana lymphoma / leukemia

Kurapa sarudzo dzeanenge achangobva kuongororwa Burkitt neBurkitt-senge lymphoma / leukemia

Kurapa sarudzo dzeanenge achangobva kuongororwa Burkitt neBurkitt-senge lymphoma / leukemia inogona kusanganisira:

• Kuvhiya kubvisa zvakanyanya bundu sezvinobvira, kuchiteverwa nekubatanidzwa chemotherapy.

• Kusanganiswa chemotherapy pamwe kana isina yakanangwa kurapwa (rituximab).

Kurapa sarudzo dzekudzokorora Burkitt uye Burkitt-senge lymphoma / leukemia

Kurapa sarudzo dzeBurkitt inodzokororwa neBurkitt-senge isiri Hodgkin lymphoma / leukemia inogona kusanganisira:

• Kusanganiswa chemotherapy pamwe kana isina yakanangwa kurapwa (rituximab).

• Yakakwira-dose chemotherapy ine stem cell yekuisa pamwe nemurwere maseru kana maseru kubva kune anopa.

• Targeted Therapy ine bispecific antibody.

• Kuongororwa kwekiriniki kunoongorora muyenzaniso wemota yemurwere kune mamwe magene ekuchinja. Rudzi rwekurapa kwakanangwa kuchapihwa kumurwere kunoenderana nerudzi rwechinjo yemajini.

Shandisa yedu kiriniki yekuyedza kutsvaga kutsvaga NCI-yakatsigirwa kenza kiriniki miedzo iri kugamuchira varwere. Unogona kutsvaga miedzo zvichibva parudzi rwecancer, zera remurwere, uye iko kunoitwa miyedzo. Ruzhinji ruzivo nezve zvekuedzwa zvekiriniki zvakare zviripo.

Kuparadzira yakakura B-cell lymphoma

Kurapa sarudzo kune ichangobva kuongororwa inoparadzira yakakura B-cell lymphoma

Kurapa sarudzo kune ichangobva kuongororwa inopararira yakakura B-cell lymphoma inogona kusanganisira:

• Kuvhiya kubvisa zvakanyanya bundu sezvinobvira, kuchiteverwa nekubatanidzwa chemotherapy.

• Kusanganiswa chemotherapy pamwe kana isina yakanangwa kurapwa (rituximab).

Kurapa sarudzo dzekudzokorora dzinoparadzira yakakura B-cell lymphoma

Kurapa sarudzo dzekudzokororazve dzakakura B-cell lymphoma inogona kusanganisira:

• Kusanganiswa chemotherapy pamwe kana isina yakanangwa kurapwa (rituximab).

• Yakakwira-dose chemotherapy ine stem cell yekuisa pamwe nemurwere maseru kana maseru kubva kune anopa.

• Targeted Therapy ine bispecific antibody.

• Kuongororwa kwekiriniki kunoongorora muyenzaniso wemota yemurwere kune mamwe magene ekuchinja. Rudzi rwekurapa kwakanangwa kuchapihwa kumurwere kunoenderana nerudzi rwechinjo yemajini.

Shandisa yedu kiriniki yekuyedza kutsvaga kutsvaga NCI-yakatsigirwa kenza kiriniki miedzo iri kugamuchira varwere. Unogona kutsvaga miedzo zvichibva parudzi rwecancer, zera remurwere, uye iko kunoitwa miyedzo. Ruzhinji ruzivo nezve zvekuedzwa zvekiriniki zvakare zviripo.

Yekutanga Mediastinal B-cell Lymphoma

Kurapa sarudzo kune ichangobva kuongororwa yepakati mediastinal B-cell lymphoma

Kurapa sarudzo kune ichangobva kuongororwa yepakati mediastinal B-cell lymphoma inogona kusanganisira:

• Kusanganiswa chemotherapy uye yakanangwa kurapwa (rituximab).

Kurapa sarudzo dzekudzokorora kwepakati pemasikati B-cell lymphoma

Kurapa sarudzo dzekudzokororwa kwepakati mediastinal B-cell lymphoma inogona kusanganisira:

• Targeted Therapy (pembrolizumab).

• Kuongororwa kwekiriniki kunoongorora muyenzaniso wemota yemurwere kune mamwe magene ekuchinja. Rudzi rwekurapa kwakanangwa kuchapihwa kumurwere kunoenderana nerudzi rwechinjo yemajini.

Shandisa yedu kiriniki yekuyedza kutsvaga kutsvaga NCI-yakatsigirwa kenza kiriniki miedzo iri kugamuchira varwere. Unogona kutsvaga miedzo zvichibva parudzi rwecancer, zera remurwere, uye iko kunoitwa miyedzo. Ruzhinji ruzivo nezve zvekuedzwa zvekiriniki zvakare zviripo.

Lymphoblastic Lymphoma

Kurapa sarudzo kune ichangobva kuongororwa lymphoblastic lymphoma

Lymphoblastic lymphoma inogona kuve yakatarwa sehosha imwechete seacute lymphoblastic leukemia (YOSE). Kurapa sarudzo ye lymphoblastic lymphoma inogona kusanganisira:

• Kusanganiswa chemotherapy. CNS prophylaxis ine radiation radiation inogona kupihwa kana gomarara rapararira kuuropi kana musana.

• Kuongororwa kwekiriniki kwemakemikripsi nema regimens akasiyana eCS prophylaxis

• Kuongororwa kwekiriniki yemubatanidzwa chemotherapy pamwe kana isina yakanangwa kurapwa (bortezomib).

Kurapa sarudzo dzekudzokorora lymphoblastic lymphoma

Kurapa sarudzo dzekudzokorora lymphoblastic lymphoma inogona kusanganisira:

• Chemotherapy.

• Yakakwira-dose chemotherapy ine stem cell yekuisa nemasero kubva kune anopa.

• Kuongororwa kwekiriniki kunoongorora muyenzaniso wemota yemurwere kune mamwe magene ekuchinja. Rudzi rwekurapa kwakanangwa kuchapihwa kumurwere kunoenderana nerudzi rwechinjo yemajini.

Shandisa yedu kiriniki yekuyedza kutsvaga kutsvaga NCI-yakatsigirwa kenza kiriniki miedzo iri kugamuchira varwere. Unogona kutsvaga miedzo zvichibva parudzi rwecancer, zera remurwere, uye iko kunoitwa miyedzo. Ruzhinji ruzivo nezve zvekuedzwa zvekiriniki zvakare zviripo.

Anaplastic Makuru Cell Lymphoma

Kurapa sarudzo dzeachangobva kuongororwa anaplastic hombe cell lymphoma

Kurapa sarudzo yeaplastic hombe cell lymphoma inogona kusanganisira:

• Kuvhiya kunoteverwa nekubatanidzwa chemotherapy.

• Kusanganiswa chemotherapy.

• Intrathecal uye systemic chemotherapy, yevarwere vane gomarara muuropi kana musana.

• Kuongororwa kwekiriniki kweakanangwa kurapwa (crizotinib kana brentuximab) uye mubatanidzwa chemotherapy.

Kurapa sarudzo dzekudzokororwa anaplastic hombe cell lymphoma

Kurapa sarudzo dzekudzokororwa anaplastic hombe cell lymphoma inogona kusanganisira:

• Chemotherapy, brentuximab, uye / kana crizotinib.

• Stem cell transplant nema murwere maseru kana maseru kubva kune anopa.

• Radiation Therapy kana yakakwira-dose chemotherapy yevarwere vane chirwere chinopfuurira kune yepakati tsinga system.

• Kuongororwa kwekiriniki kweakanangwa kurapwa (crizotinib kana brentuximab) uye mubatanidzwa chemotherapy.

• Kuongororwa kwekiriniki kunoongorora muyenzaniso wemota yemurwere kune mamwe magene ekuchinja. Rudzi rwekurapa kwakanangwa kuchapihwa kumurwere kunoenderana nerudzi rwechinjo yemajini.

Shandisa yedu kiriniki yekuyedza kutsvaga kutsvaga NCI-yakatsigirwa kenza kiriniki miedzo iri kugamuchira varwere. Unogona kutsvaga miedzo zvichibva parudzi rwecancer, zera remurwere, uye iko kunoitwa miyedzo. Ruzhinji ruzivo nezve zvekuedzwa zvekiriniki zvakare zviripo.

Lymphoproliferative Hosha Yakabatana Nekuzvidzivirira Kwemuviri muVana

Kurapa sarudzo ye lymphoproliferative chirwere chinosanganisirwa neyekutanga immunodeficiency

Kurapa sarudzo ye lymphoproliferative chirwere muvana nevechiri kuyaruka vane simba rekudzivirira immune inogona kusanganisira:

• Chemotherapy ine kana isina rituximab.

• Stem cell transplant nemaseru kubva kune anopa.

Kurapa sarudzo kune asiri-Hodgkin lymphoma inosanganisirwa neDNA kugadzirisa kukanganisa syndromes

Kurapa sarudzo kune asiri-Hodgkin lymphoma inosanganisirwa neDNA kugadzirisa kukanganisa syndromes muvana kunogona kusanganisira:

• Chemotherapy.

Kurapa sarudzo yeHIV-inosanganisirwa isiri-Hodgkin lymphoma

Kurapa neakanyanya antiretroviral therapy kana HAART (mubatanidzwa wemishonga inorwisa mabhakitiriya) inoderedza njodzi yekusave Hodgkin lymphoma mune varwere vane hutachiona hwehutachiona hwehutachiona hweHIV.

Kurapa sarudzo yehutachiona hweHIV-isina Hodgkin lymphoma (NHL) muvana inogona kusanganisira:

• Chemotherapy ine kana isina rituximab.

Nekurapa kwechirwere chinodzokororwa, sarudzo dzekurapa dzinoenderana nerudzi rweiyo isiri Hodgkin lymphoma.

Kurapa sarudzo dzepashure-yekuisa lymphoproliferative chirwere

Kurapa sarudzo dze post-transplant lymphoproliferative chirwere inogona kusanganisira:

• Kuvhiya kubvisa bundu. Kana zvichikwanisika, yakaderera madosi emununosuppressive madhiragi mushure memuti wesero kana kuisirwa nhengo inogona kupihwa.

• Targeted therapy (rituximab).

• Chemotherapy pamwe kana isina yakanangwa kurapa (rituximab).

• Kurapa kwe immunotherapy uchishandisa vanopa ma lymphocyte kana ayo masero eT emurwere kunongedza Epstein-Barr hutachiona kuri kuongororwa. Mushonga uyu unongowanikwa kune mashoma nzvimbo muUnited States.

Kazhinji NHL Inoitika muVana

Kurapa sarudzo dzevana-rudzi follicular lymphoma

Kurapa sarudzo ye follicular lymphoma muvana inogona kusanganisira:

• Kuvhiya.

• Kusanganiswa chemotherapy pamwe kana pasina rituximab.

Kune vana vane kenza ine zvimwe zvinoshanduka mumajene, kurapwa kwakafanana neicho chinopihwa kune vanhu vakuru vane follicular lymphoma. Ona iyo Follicular Lymphoma chikamu muchidimbu che pane Adult Non-Hodgkin Lymphoma kuti uwane ruzivo.

Kurapa sarudzo dze marginal zone lymphoma

Kurapa sarudzo dze marginal zone lymphoma (inosanganisira mucosa-inosanganisirwa lymphoid tishu (MALT) lymphoma) muvana inogona kusanganisira:

• Kuvhiya.

• Radiation kurapa.

• Rituximab ine kana isina chemotherapy.

• Mishonga inorwisa mabhakitiriya, yeMALT lymphoma.

Kurapa sarudzo kwekutanga CNS lymphoma

Kurapa sarudzo yekutanga CNS lymphoma muvana inogona kusanganisira:

• Chemotherapy.

Kurapa nzira dzeparutivi T-cell lymphoma

Kurapa sarudzo yemupendero T-cell lymphoma muvana inogona kusanganisira:

• Chemotherapy.

• Radiation kurapa.

• Stem cell transplant nema murwere maseru kana maseru kubva kune anopa.

Kurapa sarudzo dzechetechete T-cell lymphoma

Kurapa sarudzo dze subcutaneous panniculitis-senge inocheka T-cell lymphoma muvana inogona kusanganisira:

• Kurinda kumirira.

• Yakakwira-dose steroid.

• Targeted Therap (denileukin diftitox).

• Kusanganiswa chemotherapy.

• Retinoid kurapa.

• Stem cell kuisirwa.

Sarudzo dzekurapa dzeapacastic anaplastic yakakura cell lymphoma inogona kusanganisira

• Kuvhiya, radiation radiation, kana ese ari maviri.

Muvana, sarudzo dzekurapa dze mycosis fungoides dzinogona kusanganisira:

• Steroid inoshandiswa kuganda.

• Retinoid kurapa.

• Radiation kurapa.

• Phototherapy (light therapy inoshandisa ultraviolet B radiation).

Kuti udzidze Zvakawanda Nezvehucheche Isiri-Hodgkin Lymphoma

Kuti uwane rumwe ruzivo kubva kuNational Cancer Institute nezvehudiki husiri-Hodgkin lymphoma, ona zvinotevera:

• Computed Tomography (CT) Scans uye Cancer

• Zvinodhaka Zvinotenderwa kune Asiri-Hodgkin Lymphoma

• Ropa-Richigadzira Stem Cell Inoshandura

• Targeted Cancer Therapies

Kuti uwane rumwe ruzivo rwegomarara rehucheche uye zvimwe zvecancer zviwanikwa, ona zvinotevera:

• Nezve Kenza

• Cancers Yevacheche

• Kurapa Kutsvaga Kwevana Cancer Buda Disclaimer

• Mahedhi Ekupedzisira Ekurapwa kweKenza Yevacheche

• Vechidiki uye Vechidiki Vakuru vane Cancer

• Vana vane Cancer: Nhungamiro Yevabereki

• Kenza muVana neVachiri kuyaruka

• Stage

• Kurarama neCancer

• Mibvunzo Yekubvunza Wako Chiremba nezveCancer

• Kune Vakapona uye Vanotarisira