Mhando / lymphoma / murwere / anobatsira-ane hukama- kurapa-pdq

AIDS-Inoenderana neLymphoma Treatment (®) -Patient Shanduro

Ruzivo Ruzhinji Nezve AIDS-Inoenderana Lymphoma

PFUNGWA DZINOKOSHA

• Lymphoma ine chekuita neAIDS chirwere umo mune maseru (gomarara) maseru anoumba mune iyo lymph system yevarwere vakawana immunodeficiency syndrome (AIDS).

• Kune akawanda marudzi akasiyana e lymphoma.

• Zviratidzo zveAIDS zvine chekuita ne-lymphoma zvinosanganisira kuonda, kupisa muviri, uye kutuka kwehusiku.

• Miedzo inoongorora iyo lymph system uye zvimwe zvikamu zvemuviri zvinoshandiswa kubatsira kuona (kuwana) uye kuongorora chirwere chine hukama neAIDS-lymphoma.

• Zvimwe zvinhu zvinokanganisa kufungidzira (mukana wekupora) uye sarudzo dzekurapa.

Lymphoma ine chekuita neAIDS chirwere umo mune maseru (gomarara) maseru anoumba mune iyo lymph system yevarwere vakawana immunodeficiency syndrome (AIDS).

AIDS inokonzerwa nehutachiona hwehutachiona hwehutachiwana hwevanhu (HIV), hunorwisa nekuita kuti masoja emumuviri ashaiswe simba. Immune system isina kusimba haigone kurwisa hutachiona nezvirwere. Vanhu vane chirwere cheHIV vane njodzi yekuwedzera hutachiona uye lymphoma kana mamwe marudzi ekenza. Munhu ane HIV uye mamwe marudzi ehutachiona kana gomarara, senge lymphoma, anoonekwa seane AIDS. Dzimwe nguva, vanhu vanoonekwa kuti vane chirwere cheAIDS neAIDS-chine chekuita nemukondombera panguva imwe chete. Kuti uwane ruzivo nezveAIDS nemabatirwo ayo, tapota onai webhusaiti yeAIDSinfo.

AIDS-inosanganisirwa lymphoma rudzi rwecancer inobata iyo lymph system. Iyo lymph system chikamu chema immune system. Inobatsira kuchengetedza muviri kubva kuhutachiona nezvirwere.

Iyo lymph system inoumbwa neinotevera:

• Lymph: Isina ruvara, mvura yemvura inofamba kuburikidza nemidziyo ye lymph uye inotakura lymphocyte yaT uye B. MaLymphocyte imhando yeropa chena.

• Lymph midziyo: Netiweki yematepu matete anounganidza lymph kubva kumativi akasiyana emuviri oidzosera muropa.

• MaLymph node: Zvidiki, zvakaumbwa sebhinzi zvinochenesa lymph uye zvinochengeta masero eropa machena ayo anobatsira kurwisa hutachiona nezvirwere MaLymph node anowanikwa pamwe chete netiweki yemidziyo yema lymph mumuviri wese. Mapoka ema lymph node anowanikwa mumutsipa, underarm, mediastinum, dumbu, pelvis, uye kugomera.

• Spleen: Nhengo inogadzira maLymphocyte, inochengeta masero matsvuku eropa uye maLymphocyte, inozadza ropa, nekuparadza masero eropa ekare. Iyo spleen iri kuruboshwe kuruboshwe kwedumbu padyo nedumbu.

• Thymus: Nhengo umo T lymphocyte inokura uye ichiwanda. Iyo thymus iri muchipfuva kuseri kwebhonzo rechipfuva.

• Tonsils: maviri madiki mashoma emakemikari matema kumashure kwehuro. Pane imwe toni kune rumwe rutivi rwehuro.

• Bone marora: Iyo yakapfava, inopora matishu ari pakati pemamwe mapfupa, senge hudyu pfupa uye chipfuva chepamu. Masero machena eropa, masero matsvuku eropa, uye maplatelet anogadzirwa mumongo wemapfupa.

Lymph tishu inowanikwawo mune zvimwe zvikamu zvemuviri senge huropi, mudumbu, gland yegland, uye ganda.

Dzimwe nguva lymphoma-inoenderana neAIDS inoitika kunze kwema lymph node mumapfupa emapfupa, chiropa, meninges (membrane yakatetepa inovhara uropi) uye nemudumbu. Zvishoma kazhinji, zvinogona kuitika mune anus, moyo, bile duct, gingiva, uye mhasuru.

Anatomy yeiyo lymph system, inoratidza iyo lymph midziyo uye lymph nhengo dzinosanganisira lymph node, tonsils, thymus, spleen, uye mwongo wemapfupa. Lymph (clear fluid) uye maLymphocyte anofamba kuburikidza nemidziyo yema lymph uye mune ma lymph node uko ma lymphocyte anoparadza zvinokuvadza Iyo lymph inopinda muropa kuburikidza nemutsipa muhombe padyo nemoyo.

Kune akawanda marudzi akasiyana e lymphoma.

Lymphomas yakakamurwa kuita maviri akajairwa marudzi:

• Hodgkin lymphoma.

• Kwete-Hodgkin lymphoma.

Ose asiri Hodgkin lymphoma uye Hodgkin lymphoma anogona kuitika kune varwere vane AIDS, asi isiri Hodgkin lymphoma yakajairika. Kana munhu ane AIDS aine non-Hodgkin lymphoma, inonzi lymphoma ine chekuita neAIDS. Kana lymphoma ine chekuita neAIDS ichiitika mukati mehurongwa hwemitsipa (CNS), inonzi inonzi CNS lymphoma.

Asiri-Hodgkin lymphomas akabatanidzwa nenzira iyo masero avo anotaridzika pasi pe microscope. Vanogona kunge vasina usimbe (vanononoka kukura) kana vane hukasha (vanokurumidza kukura). MaLymphomas ane hukama neAIDS ane hukasha. Kune maviri makuru mhando dzeAIDS-inoenderana-kwete Hodgkin lymphoma:

• Kuparadzanisa yakakura B-cell lymphoma (inosanganisira B-cell immunoblastic lymphoma).

• Burkitt kana Burkitt-yakaita lymphoma.

Kuti uwane rumwe ruzivo nezve lymphoma kana cancer inosangana neAIDS, ona inotevera pfupiso:

• Vakuru Vasiri-Hodgkin Lymphoma Kurapa

• Udiki Isiri-Hodgkin Lymphoma Kurapa

• Yekutanga CNS Lymphoma Kurapa

• Kaposi Sarcoma Kurapa

Zviratidzo zveAIDS zvine chekuita ne-lymphoma zvinosanganisira kuonda, kupisa muviri, uye kutuka kwehusiku.

Izvi nezvimwe zviratidzo uye zviratidzo zvinogona kukonzerwa neAIDS-inoenderana lymphoma kana nemamwe mamiriro. Tarisa nachiremba wako kana iwe uine chero chinotevera:

• Kurera huremu kana kupisa muviri pasina chikonzero chinozivikanwa.

• Night sweats.

• Isina hurombo, yakazvimba lymph node mumutsipa, chifuva, underarm, kana kugomera.

• Kunzwa kuzara pazasi pembabvu.

Miedzo inoongorora iyo lymph system uye zvimwe zvikamu zvemuviri zvinoshandiswa kubatsira kuona (kuwana) uye kuongorora chirwere chine hukama neAIDS-lymphoma.

Iyi inotevera bvunzo uye maitiro anogona kushandiswa:

• Kuongorora kwepanyama uye nhoroondo: Kuongororwa kwemuviri kutarisa zviratidzo zvehutano, kusanganisira kuongorora zviratidzo zvehosha, zvakadai semapundu kana chero chinhu chinoratidzika sechisina kujairika. Nhoroondo yehutano hwemurwere, kusanganisira kupisa muviri, kudikitira usiku, uye kuonda, tsika dzehutano, nezvirwere zvekare uye kurapwa kuchatorwawo.

• Yakazara kuverenga kweropa (CBC): Maitiro umo muyenzaniso weropa unodhonzwa nekuongororwa zvinotevera:

• Huwandu hwemasero matsvuku eropa, machena masero eropa, uye maplatelet.

• Huwandu hwehemoglobin (protein inotakura oxygen) mumasero matsvuku eropa.

• Chikamu chemuenzaniso chakaumbwa nemasero matsvuku eropa.

Yakazara kuverenga ropa (CBC). Ropa rinounganidzwa nekupinza tsono mutsinga uye richiita kuti ropa riyerere muhubhu. Muenzaniso weropa unotumirwa murabhoritari uye masero matsvuku eropa, masero machena eropa, uye maplatelet anoverengwa. Iyo CBC inoshandiswa kuyedza, kuongorora, uye kuongorora akawanda mamiriro akasiyana.

• Ropa kemesitiri zvidzidzo: Maitiro umo muyedzo weropa unoongororwa kuyera huwandu hwezvimwe zvinhu zvakaburitswa muropa nenhengo uye nyama munyama. Chinhu chisina kujairika (chakakwirira kana chakaderera pane zvakajairwa) chiyero chechinhu chinogona kunge chiri chiratidzo chechirwere.

• LDH bvunzo: Maitiro umo muyedzo weropa unotariswa kuyera huwandu hweiyo lactic dehydrogenase. Yakawedzera huwandu hweLDH muropa inogona kunge iri chiratidzo chekukuvara kwetishu, lymphoma, kana zvimwe zvirwere.

• Hepatitis B uye hepatitis C bvunzo: Maitiro umo muyenzaniso weropa unoongororwa kuyera huwandu hwehutachiona hweH hepatitis B hutachiona-uye maanti antibodies uye huwandu hwehutachiona hweH hepatitis C hutachiona. Aya maantigen kana ma antibodies anonzi mamaki. Zviratidzo zvakasiyana kana mubatanidzwa wezviratidzo zvinoshandiswa kuona kuti murwere ane hutachiona hwehepatitis B kana C, akambotapukirwa kana kubayiwa nhomba, kana kuti anogona kubatwa nehutachiona.

• HIV bvunzo: Chiyero chekuyera huwandu hweanodzivirira hutachiona hweHIV mune muyenzaniso weropa. Maantibodies anogadzirwa nemuviri kana uchinge wapindwa nechinhu chekunze. Chikamu chepamusoro chemasoja ekudzivirira Mukondombera zvinogona kureva kuti muviri watapukirwa neHIV.

• CT scan (CAT scan): Maitiro anoita akateedzana emifananidzo yakajeka yenzvimbo dziri mukati memuviri, senge mutsipa, chifuva, dumbu, pelvis, uye lymph node, inotorwa kubva kumakona akasiyana. Mifananidzo yacho inogadzirwa nekombuta yakabatana neiyo x-ray muchina. Dhayi inogona kuiswa jekiseni kana kumedzwa kubatsira nhengo kana zvinyama kuratidza zvakajeka. Iyi nzira inonziwo computed tomography, computerized tomography, kana komputa axial tomography.

• PET scan (positron emission tomography scan): Iyo nzira yekuwana yakaipa malonda maseru mumuviri. Chishoma che radioactive glucose (shuga) inoiswa mutsinga. Iyo PET scanner inotenderera yakatenderedza muviri uye inogadzira mufananidzo wepo glucose iri kushandiswa mumuviri. Malignant tumarara maseru anoratidza kupenya mumufananidzo nekuti anoshanda uye anotora glucose yakawanda kupfuura zvinoita maseru akajairwa.

• Bone marrow aspiration uye biopsy: Kubviswa kwemongo wepfupa uye chidimbu chefupa nekuisa tsono isina mhango muhudyu kana pfupa rechipfuva. Nyanzvi yezvirwere anoona pfupa nemabhonzo pasi pe microscope kutsvaga zviratidzo zvecancer.

Bone marora chishuwo uye biopsy. Mushure mekunge nzvimbo diki yeganda yave nechiveve, tsono yemongo wemapfupa inoiswa mupfupa rehudyu remurwere. Samples reropa, bhonzo, uye mwongo wemapfupa zvinobviswa kuti zviongororwe pasi pe microscope.

• Lymph node biopsy: Kubviswa kwezvose kana chikamu chema lymph node. Nyanzvi yezvirwere anoona tishu pasi pe microscope kutsvaga maseru ekenza. Imwe yedzinotevera mhando dze biopsies dzinogona kuitwa:

• Excisional biopsy: Kubviswa kweiyo lymph node.

• Incisional biopsy: Kubviswa kwechikamu chema lymph node.

• Core biopsy: Kubviswa kwetishu kubva kune lymph node uchishandisa yakafara tsono.

Dzimwe nzvimbo dzemuviri, senge chiropa, mapapu, bone, mwongo wemapfupa, uye huropi, dzinogona zvakare kuve nemuenzaniso wetissue wakabviswa uye kuongororwa neanorwara zviratidzo zvecancer.

Kana gomarara rikawanikwa, bvunzo dzinotevera dzinogona kuitwa kuongorora maseru ekenza:

• Immunohistochemistry: Kuongororwa kwerabhoritari inoshandisa masoja ekudzivirira mamwe maantigen (mamaki) mune imwe sampuro yetishu yemurwere. Masoja ekudzivirira chirwere anowanzo sunganidzwa ne enzyme kana dhayi ye fluorescent. Mushure mekunge maantibodies akasunga kune yakasarudzika antigen mune yeiyo sampuli, iyo enzyme kana dhayi inogoneswa, uye iyo antigen inogona kuzoonekwa pasi pe microscope. Rudzi urwu rweyedzo runoshandiswa kubatsira kuongorora gomarara uye kubatsira kutaurira imwe mhando yekenza kubva kune imwe mhando yegomarara.

• Kuongorora kweCytogenetic: Kuongororwa kwerabhoritari umo ma chromosomes emaseru mune muyenzaniso weropa kana mongo wemapfupa anoverengwa uye kuongororwa chero shanduko, sekutyorwa, kushaikwa, kurongedzwa patsva, kana mamwe ma chromosomes. Shanduko mune mamwe ma chromosomes inogona kunge iri chiratidzo checancer. Kuongorora kweCytogenetic kunoshandiswa kubatsira kuongorora cancer, kuronga kurapwa, kana kuona kuti kurapa kuri kushanda sei.

• FISH (fluorescence in situ hybridization): Kuedzwa kwerabhoritari kunoshandiswa kutarisa uye kuverenga majeni kana ma chromosomes mumasero nematukisi. Zvidimbu zveDNA zvine dhayi ye fluorescent zvinogadzirwa murabhoritari uye zvinowedzerwa kune imwe sampuli yemasero emurwere kana zvinyama. Kana zvidimbu izvi zvakavezwa zveDNA zvonamatira kune mamwe mageneti kana nzvimbo dzekromosomes mumuenzaniso, dzinovhenekera kana dzatariswa pasi pefluorescent microscope. Chiyero cheFISH chinoshandiswa kubatsira kuongorora kenza uye kubatsira kuronga kurapwa.

• Immunophenotyping: Kuongororwa kwerabhoritari inoshandisa masoja ekudzivirira kenza maseru zvichibva pamhando dzemaantigen kana mamaki ari pamusoro pemasero. Uyu muedzo unoshandiswa kubatsira kuongorora chaiwo marudzi e lymphoma.

Zvimwe zvinhu zvinokanganisa kufungidzira (mukana wekupora) uye sarudzo dzekurapa.

Kufungidzira (mukana wekupora) uye sarudzo dzekurapa dzinoenderana nezvinotevera:

• Chikamu checancer.

• Zera remurwere.

• Huwandu hwemaCD4 lymphocyte (rudzi rwechena reropa) muropa.

• Kuwanda kwenzvimbo mumuviri lymphoma kunowanikwa kunze kweiyo lymph system.

• Kunyangwe murwere ane nhoroondo ye intravenous (IV) kushandisa zvinodhaka.

• Kugona kwemurwere kuita zviitiko zvezuva nezuva.

Matanho eAIDS-Akabatana Lymphoma

PFUNGWA DZINOKOSHA

• Mushure mokunge chirwere cheAIDS chine chekuita neAIDS chaonekwa, kuongororwa kunoitwa kuti uone kana masero ekenza apararira mukati meiyo lymph system kana kune zvimwe zvikamu zvemuviri.

• Pane nzira nhatu dzinopararira negomarara mumuviri.

• Matanho anotevera anoshandiswa kune anosangana neAIDS lymphoma:

• Chikamu I

• Chikamu II

• Chikamu chechitatu

• Chikamu IV

• Nekurapwa, maLymphomas ane hukama neAIDS akarongedzwa zvichienderana nekwavakatangira mumuviri, zvinotevera:

• Peripheral / systemic lymphoma

• Yekutanga CNS lymphoma

Mushure mokunge chirwere cheAIDS chine chekuita neAIDS chaonekwa, kuongororwa kunoitwa kuti uone kana masero ekenza apararira mukati meiyo lymph system kana kune zvimwe zvikamu zvemuviri.

Maitiro anoshandiswa kutsvaga kana gomarara maseru apararira mukati meiyo lymph system kana kune zvimwe zvikamu zvemuviri zvinonzi staging. Ruzivo rwakaunganidzwa kubva munzira yekugadzwa rinotara danho rechirwere. Zvakakosha kuziva danho kuitira kuronga kurapwa, asi chirwere cheAIDS chine chekuita neAIDS chinowanzo fambira mberi kana chikaonekwa.

Iyi inotevera bvunzo uye maitiro anogona kushandiswa mune yekuratidzira maitiro:

• MRI (magnetic resonance imaging) ine gadolinium: Maitiro anoshandisa magineti, masaisai eredhiyo, uye komputa kugadzira yakateedzana mifananidzo yakajeka yenzvimbo dziri mukati memuviri, senge huropi uye musana. Chinhu chinonzi gadolinium chinojowa mumurwere kuburikidza netsinga. Iyo gadolinium inounganidza yakatenderedza maseru ekenza kuitira kuti varatidze kupenya mumufananidzo. Iyi nzira inonziwo nyukireya magnetic resonance imaging (NMRI).

• Lumbar puncture: Maitiro anoshandiswa kutora cerebrospinal fluid (CSF) kubva pamutsipa wepelinha. Izvi zvinoitwa nekuisa tsono pakati pemabhonzo maviri mumuzongoza nekupinda muCSF yakakomberedza musana uye kubvisa sampu yemvura. Muenzaniso weCSF unotariswa pasi pe microscope yezviratidzo zvekuti gomarara rapararira kuuropi uye musana. Muenzaniso unogona zvakare kuongororwa hutachiona hweEpstein-Barr. Maitiro aya anonzi zvakare LP kana musana tap.

Lumbar kubaya. Murwere akarara panzvimbo yakamonana patafura. Mushure mekunge diki nzvimbo kumucheto kumashure yave chiveve, tsono yemusana (tsono refu, nhete) inoiswa muchikamu chezasi chepamuviri mbichana kubvisa cerebrospinal fluid (CSF, inoratidzwa mublue). Mvura yacho inogona kutumirwa kurabhoritari kunoongororwa.

Pane nzira nhatu dzinopararira negomarara mumuviri.

Kenza inogona kupararira kuburikidza nematinji, iyo lymph system, uye neropa:

• Tishu. Kenza inopararira kubva kwayakatanga nekukura ichipinda munzvimbo dziri pedyo.

• Lymph maitiro. Kenza inopararira kubva kwayakatanga nekupinda muiyo lymph system. Kenza inofamba nemumidziyo yema lymph ichienda kune dzimwe nhengo dzemuviri.

• Ropa. Kenza inopararira kubva payakatanga nekupinda muropa. Kenza inofamba nemidzi yeropa ichienda kune dzimwe nhengo dzemuviri.

Matanho anotevera anoshandiswa kune anosangana neAIDS lymphoma:

Chikamu I

Chikamu ini munhu mukuru lymphoma. Gomarara rinowanikwa mune imwe kana anopfuura mamwe ma "lymph node" muboka rema "lymph node" kana, mune zvisingawanzoitika, kenza inowanikwa mhete yeWaldeyer, thymus, kana spleen. Muchikamu IE (isina kuratidzwa), gomarara rapararira kune imwe nzvimbo kunze kweiyo lymph system.

Chikamu I-chine chekuita neAIDS chakakamurwa muzvikamu ini neIE.

• Muchikamu ini, kenza inowanikwa mune imwe yenzvimbo dzinotevera mune lymph system:

• Imwe kana anopfuura mamwe ma lymph node muboka rema lymph node.

• Mhete yaWaldeyer.

• Thymus.

• Spleen.

• Muchikamu IE, kenza inowanikwa mune imwe nharaunda kunze kweiyo lymph system.

• Chikamu II

• Chikamu chechipiri II chine chekuita neAIDS-chinokamhina chakakamurwa muzvikamu II uye IIE.

• Muchikamu chechipiri, kenza inowanikwa mumapoka maviri kana anopfuura emakemikari mairi ari pamusoro pechidziro kana pazasi pechidzitiro.

Chikamu II munhu mukuru lymphoma. Gomarara rinowanikwa mune maviri kana anopfuura mapoka ema lymph node ayo ari pamusoro pechirafu kana pazasi pechirafu.

• Muchikamu IIE, kenza yakapararira kubva kuboka rema lymph node kuenda kunzvimbo iri padyo iri kunze kwenzira yema lymph. Kanzera inogona kunge yakapararira kune mamwe ma lymph node mapoka kudivi rimwe reiyo diaphragm.

Chikamu IIE munhu mukuru lymphoma. Kenza yapararira kubva kuboka rema lymph node kuenda kunzvimbo iri padyo iri kunze kwenzira yema lymph. Kanzera inogona kunge yakapararira kune mamwe ma lymph node mapoka kudivi rimwe reiyo diaphragm.

Muchikamu chechipiri, izwi rekuti bulky chirwere rinoreva hombe kukura. Hukuru hwehuturu hunorehwa hunonzi chirwere chakakura hunosiyana zvichienderana nerudzi rwe lymphoma.

Chikamu chechitatu

Chikamu chechitatu munhu mukuru lymphoma. Gomarara rinowanikwa mumapoka ema lymph node ese ari pamusoro nepazasi peya diaphragm; kana muboka rema lymph node pamusoro pechirafu uye mupleen.

Muchikamu chechitatu-chine chekuita neAIDS-lymphoma, kenza inowanikwa:

• mumapoka ema lymph node kumusoro nekuzasi kwedhayaphirafu; kana

• mune lymph nodes pamusoro pechipfuva uye mupleen.

Chikamu IV

Chikamu IV munhu mukuru lymphoma. Gomarara (a) rakapararira mukati memumwe kana anopfuura nhengo kunze kwenzira yemajuku; kana (b) inowanikwa mumapoka maviri kana anopfuura emakiropu ari pamusoro pechirafu kana pazasi pechidhiraivho uye mune imwe nhengo iri kunze kwenzira uye isiri pedyo nenhengo dzakakanganiswa; kana (c) inowanikwa mumapoka enhengo dzenzamu pamusoro peya diaphragm uye pazasi pechidhiramu nechero nhengo iri kunze kwetsinga; kana (d) inowanikwa muchiropa, mwongo wemabhonzo, nzvimbo dzinopfuura imwechete mumapapu, kana cerebrospinal fluid (CSF). Kenza haina kupararira yakananga muchiropa, mwongo wemapfupa, mapapu, kana CSF kubva kuma lymph node ari padyo.

Muchikamu IV chine hukama neAIDS-lymphoma, cancer.

• yakapararira mukati memumwe kana akawanda nhengo kunze kwenzvimbo yemajukunzi; kana

• inowanikwa mumapoka maviri kana anopfuura emakirini mairi anenge ari pamusoro pechipfuva kana pasi pechidimbu uye mune imwe nhengo iri kunze kwenzvimbo yema lymph uye kwete padhuze nema lymph node akakanganiswa; kana

• inowanikwa mumapoka ema lymph node ese ari pamusoro uye pazasi peya diaphragm uye mune chero nhengo iri kunze kweiyo lymph system; kana

• inowanikwa muchiropa, pfupa remongo, nzvimbo dzinopfuura imwechete mumapapu, kana cerebrospinal fluid (CSF). Kenza haina kupararira yakananga muchiropa, mwongo wemapfupa, mapapu, kana CSF kubva kuma lymph node ari padyo.

Varwere vane hutachiona hweEpstein-Barr hutachiona kana avo vane chirwere chine chekuita neAIDS chinonzi lymphoma chinokanganisa mwongo wemapfupa vane njodzi yakawanda yekenza inopararira kune yepakati tsinga system (CNS).

Nekurapwa, maLymphomas ane hukama neAIDS akarongedzwa zvichienderana nekwavakatangira mumuviri, zvinotevera:

Peripheral / systemic lymphoma

Lymphoma iyo inotanga mune lymph system kana kumwe kunhu mumuviri, kunze kwehuropi, inonzi peripheral / systemic lymphoma. Inogona kupararira mumuviri wese, kusanganisira kuuropi kana pfupa remongo. Iyo inowanzo kuongororwa muchikamu chemberi.

Yekutanga CNS lymphoma

Chekutanga CNS lymphoma inotanga pakati nepakati tsinga (huropi uye musana). Iyo yakabatana nehutachiona hweEpstein-Barr. Lymphoma iyo inotanga kumwe kunhu mumuviri uye inopararira kune yepakati tsinga system haisi yekutanga CNS lymphoma.

Kurapa Sarudzo Kuongorora

PFUNGWA DZINOKOSHA

• Kune marudzi akasiyana ekurapa kwevarwere vane chirwere chine chekuita neAIDS chinonzi lymphoma.

• Kurapa kweAIDS-inoenderana lymphoma inosanganisa kurapwa kweiyo lymphoma nekurapa kweAIDS.

• Mhando ina dzekurapa kwakajairika dzinoshandiswa:

• Chemotherapy

• Radiation kurapa

• Yakakwira-dose chemotherapy ine stem cell yekuisa

• Targeted kurapwa

• Mhando nyowani dzekurapa dziri kuyedzwa mumakiriniki ekuedzwa.

• Kurapa kweAIDS-inoenderana lymphoma kunogona kukonzera mhedzisiro.

• Varwere vangangoda kufunga nezve kutora chikamu mukutora kiriniki.

• Varwere vanogona kupinda mumakiriniki miedzo vasati, panguva, kana mushure mekutanga kwavo kenza kurapwa.

• Yekutevera-bvunzo inogona kudikanwa.

Kune marudzi akasiyana ekurapa kwevarwere vane chirwere chine chekuita neAIDS chinonzi lymphoma.

Mhando dzakasiyana dzekurapa dzinowanikwa kune varwere vane chirwere cheAIDS-chine chekuita nemukondombera. Mamwe marapirwo akajairwa (iko kurapwa kwazvino kwashandiswa), uye kumwe kuedzwa mumakiriniki ekuedzwa A kurapwa kiriniki kuyedzwa chidzidzo chekutsvaga chakaitirwa kubatsira kuvandudza marapirwo azvino kana kuwana ruzivo marapirwo matsva evarwere vane gomarara. Kana kiriniki miedzo ikaratidza kuti kurapwa kutsva kuri nani pane kwese kurapwa, kurapwa kutsva kunogona kuve kwakajairwa kurapwa. Varwere vangangoda kufunga nezve kutora chikamu mukutora kiriniki. Mimwe miedzo yekiriniki yakavhurwa chete kune varwere vasina kutanga kurapwa.

Kurapa kweAIDS-inoenderana lymphoma inosanganisa kurapwa kweiyo lymphoma nekurapa kweAIDS.

Varwere vane AIDS vakashayisa simba immune system uye kurapwa kunogona kukonzera kuti immune system itowedzera kushomeka. Nechikonzero ichi, kurapa varwere vane chirwere chine chekuita neAIDS chinonetsa uye vamwe varwere vanogona kurapwa nemadosi emushonga pane evarume vane lymphoma vasina AIDS.

Yakawanda inoshanda antiretroviral therapy (HAART) inoshandiswa kudzikisa kukanganisa kwe immune immune kunokonzerwa neHIV. Kurapa ne HAART kunogona kubvumidza vamwe varwere vane chirwere chine chekuita neAIDS-lymphoma kuti vagamuchire zvakachengeteka anticancer mishonga mune yakajairwa kana yakakwira doses Mune ava varwere, kurapwa kunogona kushanda sezvazvinoita muvarwere vema lymphoma vasina AIDS. Mushonga wekudzivirira nekurapa hutachiona, izvo zvinogona kuve zvakakomba, unoshandiswa zvakare.

Kuti uwane rumwe ruzivo nezve AIDS uye kurapwa kwayo, ndapota tarisa AIDSinfo webhusaiti.

Mhando ina dzekurapa kwakajairika dzinoshandiswa:

Chemotherapy

Chemotherapy mushonga wekenza unoshandisa mishonga kumisa kukura kwemasero ekenza, kungave nekuuraya maseru kana nekuamisa iwo kubva pakupatsanuka. Kana chemotherapy ikatorwa nemuromo kana kujowa mutsinga kana mhasuru, mishonga inopinda muropa uye inogona kusvika masero emukenza mumuviri wese (systemic chemotherapy). Kana chemotherapy ikaiswa yakanangana necerebrospinal fluid (intrathecal chemotherapy), nhengo, kana dumbu remuviri senge dumbu, mishonga inonyanya kukanganisa maseru ekenza munzvimbo idzodzo (chemotherapy yedunhu). Kusanganiswa chemotherapy kurapwa kunoshandisa anopfuura imwe anticancer mushonga.

Nzira iyo chemotherapy inopihwa zvinoenderana nekenza kenza. Intrathecal chemotherapy inogona kushandiswa mune varwere vane mukana wekuti vave ne lymphoma mukatikati medhu system (CNS).

Intrathecal chemotherapy. Anticancer zvinodhaka zvinopinda mukati meiyo intrathecal nzvimbo, inova iyo nzvimbo inobata iyo cerebrospinal fluid (CSF, inoratidzwa mublue). Pane nzira mbiri dzakasiyana dzekuita izvi. Imwe nzira, inoratidzwa muchikamu chepamusoro chemufananidzo, kuisa majekiseni mumugodhi weOmaya (mudziyo wakaita sedome wakaiswa pasi peganda panguva yekuvhiyiwa; inobata mishonga painenge ichiyerera nepombi diki ichienda muuropi ). Imwe nzira, inoratidzwa muchikamu chepazasi chemufananidzo, kupinza mishonga yakananga muCSF muchikamu chepazasi chechipenga chemusana, mushure mekunge nzvimbo diki kumusana wezasi yave nechiveve.

Chemotherapy inoshandiswa pakurapa kweAIDS-inoenderana neparipheral / systemic lymphoma. Hazvisati zvazivikanwa kana zviri nani kupa HAART panguva imwe chete sechemotherapy kana mushure mekunge chemotherapy yapera.

Colony-inokurudzira zvinhu dzimwe nguva inopihwa pamwechete nekemotherapy. Izvi zvinobatsira kudzikisira mhedzisiro mhedzisiro chemotherapy inogona kuve pane iyo pfupa remongo

Radiation kurapa

Radiation kurapa kurapwa kenza iyo inoshandisa yakakwira-simba x-rays kana mamwe marudzi e radiation kuuraya cancer maseru kana kuachengeta iwo kuti asakure. Kune mhando mbiri dze radiation radiation:

• External radiation therapy inoshandisa muchina uri kunze kwemuviri kutumira radiation kune kenza.

• Yemukati radiation kurapwa kunoshandisa radioactive chinhu chakavharirwa mune tsono, mhodzi, waya, kana makateti anoiswa akananga mukati kana padyo nekenza.

Maitiro ekurapwa nemwaranzi anopiwa zvinoenderana nekenza kenza. External radiation therapy inoshandiswa kurapa zvine chekuita neAIDS CNS lymphoma.

Yakakwira-dose chemotherapy ine stem cell yekuisa

Yakakwira madosi ekemotherapy anopiwa kuuraya cancer maseru. Masero ane hutano, kusanganisira masero anogadzira ropa, anoparadzwa nekenza kurapwa. Stem cell transplant kurapwa kwekutsiva maseru anogadzira ropa. Masero emashizha (masero eropa asina kusimba) anobviswa muropa kana mwongo wemapfupa emurwere uye akaomeswa nechando uye akachengetwa. Mushure mekunge murwere apedza chemotherapy, maseru akachengetwa anonyungudutswa uye ndokudzoserwa kumurwere kuburikidza nekumukiswa. Aya akadzikiswa maseru emadzinde anokura kuita (uye kudzoreredza) masero eropa emuviri.

Targeted kurapwa

Targeted therapy mhando yekurapa inoshandisa zvinodhaka kana zvimwe zvinhu kuti zvione uye kurwisa chaiwo maseru ekenza pasina kukuvadza zvakajairika maseru. Monoclonal antibody therapy imhando yekurapa kwakanangwa.

Monoclonal antibody therapy ndeye kenza kurapa iyo inoshandisa antibodies inogadzirwa murabhoritari kubva kune imwechete mhando ye immune immune cell. Aya ma antibodies anokwanisa kuona zvinhu pane cancer cancer kana zvakajairika zvinhu zvinogona kubatsira gomarara maseru kukura. Masoja ekudzivirira chirwere anonamira pazvinhu uye anouraya maseru egomarara, anovharira kukura kwawo, kana kuti aachengetedze kubva pakupararira. Monoclonal antibodies inopihwa nekumisirwa. Izvi zvinogona kushandiswa ndoga kana kutakura zvinodhaka, chepfu, kana zvinhu zvine radioactive zvakananga kumasero ekenza. Rituximab inoshandiswa pakurapa kweAIDS-inoenderana neparipheral / systemic lymphoma.

Mhando nyowani dzekurapa dziri kuyedzwa mumakiriniki ekuedzwa.

Ruzivo nezve kiriniki miedzo inowanikwa kubva kuNCI webhusaiti.

Kurapa kweAIDS-inoenderana lymphoma kunogona kukonzera mhedzisiro.

Kuti uwane ruzivo nezve mhedzisiro inokonzerwa nekurapwa kwegomarara, ona yedu Side Mhedzisiro peji.

Varwere vangangoda kufunga nezve kutora chikamu mukutora kiriniki.

Kune vamwe varwere, kutora chikamu mumuedzo wekiriniki inogona kunge iri sarudzo yekurapa yakanyanya kunaka. Kliniki miedzo chikamu chekenza tsvagiridzo. Zvemakiriniki miedzo inoitwa kuti uone kana marapirwo matsva egomarara akachengeteka uye achishanda kana zvirinani pane akajairwa kurapwa.

Mazhinji emazuva ano marapirwo akajairwa ekenza akavakirwa pamavambo emakiriniki ekuedzwa. Varwere vanotora chikamu mukuyedzwa kwekiriniki vanogona kuwana kurapwa kwakaringana kana kuve pakati pevekutanga kurapwa kutsva.

Varwere vanotora chikamu mumiedzo yekiriniki zvakare vanobatsira kugadzirisa marapirwo achaitwa kenza mune ramangwana. Kunyangwe kana miedzo yemakiriniki isinga tangire kumarapirwo matsva anoshanda, anowanzo pindura mibvunzo yakakosha uye anobatsira kufambisira mberi kutsvagurudza.

Varwere vanogona kupinda mumakiriniki miedzo vasati, panguva, kana mushure mekutanga kwavo kenza kurapwa.

Mimwe miedzo yekiriniki inosanganisira chete varwere vasati vagamuchira kurapwa. Mimwe miedzo yekuedza kurapwa kwevarwere vane kenza haina kuve nani. Kune mamwezve emakiriniki miedzo inoedza nzira nyowani dzekumisa cancer kubva kudzokororazve (kudzoka) kana kudzikisira mhedzisiro yemakenza kurapwa.

Kuedzwa kwemakiriniki kuri kuitika munzvimbo zhinji dzenyika. Ruzivo nezve kiriniki miedzo inotsigirwa neNCI inogona kuwanikwa paNCI yekiriniki miedzo yekutsvaga peji rewebhu. Kliniki miedzo inotsigirwa nemamwe masangano inogona kuwanikwa pane yeClinicalTrials.gov webhusaiti.

Yekutevera-bvunzo inogona kudikanwa.

Mimwe miedzo yakaitwa kuongorora gomarara kana kutsvaga danho rekenza inogona kudzokororwa. Dzimwe bvunzo dzinodzokororwa kuitira kuti vaone kuti kurapa kuri kushanda sei. Sarudzo nezvekuti uenderere mberi, shandura, kana kumisa kurapwa kunogona kunge kuchibva pamhedzisiro yeiyi bvunzo.

Mimwe bvunzo ichaenderera ichiitwa nguva nenguva mushure mekunge kurapwa kwapera. Mhedzisiro yeiyi bvunzo inogona kuratidza kana mamiriro ako achinja kana kana gomarara radzoka (dzoka). Iyi bvunzo dzimwe nguva inonzi yekuteedzera-bvunzo kana kuongorora-kumusoro.

Kurapa Sarudzo dzeAIDS-Inoenderana neLymphoma

Muchikamu chino

• AIDS-Inoenderana nePeripheral / Systemic Lymphoma

• AIDS-Inoenderana Nechepakati Nervous System Lymphoma

Kuti uwane ruzivo nezve marapirwo akanyorwa pazasi, ona iyo Chikamu Sarudzo Yekutarisa Chikamu.

AIDS-Inoenderana nePeripheral / Systemic Lymphoma

Kurapa kwehutachiona hwehutachiona hweAIDS / systemic lymphoma inogona kusanganisira zvinotevera:

• Kubatanidzwa chemotherapy pamwe kana isina yakanangwa kurapwa.

• High-dose chemotherapy uye stem cell transplant, ye lymphoma iyo isina kupindura kurapwa kana kudzoka.

• Intrathecal chemotherapy ye lymphoma iyo inogona kupararira kune central nervous system (CNS).

Shandisa yedu kiriniki yekuyedza kutsvaga kutsvaga NCI-yakatsigirwa kenza kiriniki miedzo iri kugamuchira varwere. Unogona kutsvaga miedzo zvichibva parudzi rwecancer, zera remurwere, uye iko kunoitwa miyedzo. Ruzhinji ruzivo nezve zvekuedzwa zvekiriniki zvakare zviripo.

AIDS-Inoenderana Nechepakati Nervous System Lymphoma

Kurapa kweAIDS-inoenderana nepakati central nervous system lymphoma inogona kusanganisira zvinotevera:

• External radiation kurapwa.

Shandisa yedu kiriniki yekuyedza kutsvaga kutsvaga NCI-yakatsigirwa kenza kiriniki miedzo iri kugamuchira varwere. Unogona kutsvaga miedzo zvichibva parudzi rwecancer, zera remurwere, uye iko kunoitwa miyedzo. Ruzhinji ruzivo nezve zvekuedzwa zvekiriniki zvakare zviripo.

Kudzidza Zvakawanda Nezve Aids-Inoenderana neLymphoma

Kuti uwane rumwe ruzivo kubva kuNational Cancer Institute nezveAIDS-inoenderana lymphoma, ona zvinotevera:

• Ropa-Richigadzira Stem Cell Inoshandura

• Targeted Cancer Therapies

Kuti uwane ruzivo rwekenza uye zvimwe zviwanikwa kubva kuNational Cancer Institute, ona zvinotevera:

• Nezve Kenza

• Stage

• Chemotherapy uye Iwe: Tsigiro Yevanhu Vane Kenza

• Radiation Therapy uye Iwe: Rutsigiro rweVanhu Vane Kenza

• Kurarama neCancer

• Mibvunzo Yekubvunza Wako Chiremba nezveCancer

• Kune Vakapona uye Vanotarisira