Types/lymphoma/patient/adult-nhl-treatment-pdq

Vakuru Vasiri-Hodgkin Lymphoma Kurapa (®) -Patient Shanduro

Ruzivo Ruzhinji Nezve Mukuru Asiri-Hodgkin Lymphoma

PFUNGWA DZINOKOSHA

• Isiri-Hodgkin lymphoma chirwere umo mune yakaipa (gomarara) maseru anoumba mune lymph system.

• Kwete-Hodgkin lymphoma inogona kunge isinganetsi kana ine hukasha.

• Kuchembera, kuve murume, uye kuve nehutachiona hwemuviri kunogona kuwedzera njodzi yevakuru vasiri-Hodgkin lymphoma.

• Zviratidzo nezviratidzo zvevakuru vasiri-Hodgkin lymphoma zvinosanganisira kuzvimba lymph node, fivha, kunwisa kudikitira usiku, kupera muviri, uye kuneta.

• Kuyedza kunoongorora iyo lymph system uye zvimwe zvikamu zvemuviri zvinoshandiswa kubatsira kuongorora uye kuyera vakuru vasina-Hodgkin lymphoma.

• Zvimwe zvinhu zvinokanganisa kufungidzira (mukana wekupora) uye sarudzo dzekurapa.

Isiri-Hodgkin lymphoma chirwere umo mune yakaipa (gomarara) maseru anoumba mune lymph system.

Kwete-Hodgkin lymphoma rudzi rwekenza inogadzirwa mune iyo lymph system. Iyo lymph system chikamu chema immune system. Inobatsira kuchengetedza muviri kubva kuhutachiona nezvirwere.

Iyo lymph system inoumbwa neinotevera:

• Lymph: Isina ruvara, mvura inoyerera iyo inofamba kuburikidza nemidziyo ye lymph uye inotakura maLymphocyte (machena masero eropa). Kune matatu marudzi e lymphocyte:

• B ma lymphocyte anogadzira masoja ekudzivirira chirwere. Inonziwo masero B. Mhando zhinji dzisiri-Hodgkin lymphoma dzinotanga muB lymphocyte.

• T lymphocyte dzinobatsira B lymphocyte kugadzira masoja ekudzivirira anobatsira kurwisa hutachiona. Iyo inonziwo T seli.

• Maseru anouraya chaiwo anorwisa cancer maseru uye hutachiona. Iyo inonziwo NK masero.

• Lymph midziyo: Netiweki yematepu matete anounganidza lymph kubva kumativi akasiyana emuviri oidzosera muropa.

• MaLymph node: Zvidiki, zvakaumbwa sebhinzi zvinochenesa lymph uye zvinochengeta masero eropa machena ayo anobatsira kurwisa hutachiona nezvirwere MaLymph node anowanikwa pamwe chete netiweki yemidziyo yema lymph mumuviri wese. Mapoka ema lymph node anowanikwa mumutsipa, underarm, mediastinum, dumbu, pelvis, uye kugomera.

• Spleen: Nhengo inogadzira maLymphocyte, inochengeta masero matsvuku eropa uye maLymphocyte, inozadza ropa, nekuparadza masero eropa ekare. Iyo spleen iri kuruboshwe kuruboshwe kwedumbu padyo nedumbu.

• Thymus: Nhengo umo T lymphocyte inokura uye ichiwanda. Iyo thymus iri muchipfuva kuseri kwebhonzo rechipfuva.

• Tonsils: maviri madiki mashoma emakemikari matema kumashure kwehuro. Pane imwe toni kune rumwe rutivi rwehuro.

• Bone marora: Iyo yakapfava, inopora matishu ari pakati pemamwe mapfupa, senge hudyu pfupa uye chipfuva chepamu. Masero machena eropa, masero matsvuku eropa, uye maplatelet anogadzirwa mumongo wemapfupa.

Anatomy yeiyo lymph system, inoratidza iyo lymph midziyo uye lymph nhengo dzinosanganisira lymph node, tonsils, thymus, spleen, uye mwongo wemapfupa. Lymph (clear fluid) uye maLymphocyte anofamba kuburikidza nemidziyo yema lymph uye mune ma lymph node uko ma lymphocyte anoparadza zvinokuvadza Iyo lymph inopinda muropa kuburikidza nemutsipa muhombe padyo nemoyo.

Lymph tishu inowanikwawo mune dzimwe nzvimbo dzomuviri dzakadai sechigadziko chedumbu, bronchus, uye ganda. Gomarara rinogona kutapukira kuchiropa nemapapu.

Kune maviri maviri akajairwa marudzi e lymphomas: Hodgkin lymphoma uye isiri Hodgkin lymphoma. Iyi pfupiso ndeyekurapa kwevanhu vakuru vasiri-Hodgkin lymphoma, kusanganisira panguva yekuzvitakura.

Kuti uwane rumwe ruzivo nezve mamwe marudzi e lymphoma, ona inotevera pfupiso:

• Vakuru Acute Lymphoblastic Leukemia Treatment (lymphoblastic lymphoma)

• Mukuru Hodgkin Lymphoma Kurapa

• AIDS-Inoenderana neLymphoma Kurapa

• Udiki Isiri-Hodgkin Lymphoma Kurapa

• Chirwere cheLymphocytic Leukemia Kurapa (diki lymphocytic lymphoma)

• Mycosis Fungoides (Kusanganisira Sézary Syndrome) Kurapa (yakatemwa T-cell lymphoma)

• Yekutanga CNS Lymphoma Kurapa

Kwete-Hodgkin lymphoma inogona kunge isinganetsi kana ine hukasha.

Kwete-Hodgkin lymphoma inokura uye inopararira pamitengo yakasiyana uye inogona kuve isinganetsi kana ine hukasha. Indolent lymphoma inowedzera kukura uye inopararira zvishoma nezvishoma, uye ine mashoma zviratidzo nezviratidzo. Aggressive lymphoma inokura uye inopararira nekukurumidza, uye ine zviratidzo nezviratidzo zvinogona kuve zvakanyanya. Mishonga yekurapa uye ine hukasha lymphoma zvakasiyana.

Ichi chidimbu chiri pamusoro pemhando dzinotevera dzisiri-Hodgkin lymphoma:

Indolent isiri-Hodgkin lymphomas

Follicular lymphoma. Follicular lymphoma ndiyo inonyanya kufararira indolent isiri-Hodgkin lymphoma. Iyo inononoka-kukura mhando yeiyo isiri-Hodgkin lymphoma iyo inotanga muB B lymphocyte. Iyo inokanganisa ma lymph node uye inogona kupararira kune iyo yemongo kana spleen. Vazhinji varwere vane follicular lymphoma vane makore makumi mashanu ekuberekwa kana vakuru pavanoonekwa. Follicular lymphoma inogona kuenda isina kurapwa. Murwere anonyatsotariswa zviratidzo kana zviratidzo zvekuti chirwere chadzoka. Kurapa kunodiwa kana zviratidzo kana zviratidzo zvikaitika mushure mekunge kenza yanyangarika kana mushure mekutanga kurapwa kenza. Dzimwe nguva follicular lymphoma inogona kuve inotyisa mhando ye lymphoma, yakadai sekuparadzira yakakura B-cell lymphoma.

Lymphoplasmacytic lymphoma. Muzviitiko zvakawanda zve lymphoplasmacytic lymphoma, B lymphocyte ayo ari kushanduka kuita masero eplasma anoita huwandu hwakawanda hweprotein inonzi monoclonal immunoglobulin M (IgM) antibody. Yakakwira mazinga eIgM antibody muropa inokonzera kuti iro plasma reropa riwedzere. Izvi zvinogona kukonzera zviratidzo kana zviratidzo sekutambudzika kuona kana kunzwa, matambudziko emoyo, kufema kwekufema, kutemwa nemusoro, dzungu, uye kuveveve kana kurira kwemaoko netsoka. Dzimwe nguva hapana zviratidzo kana zviratidzo zve lymphoplasmacytic lymphoma. Inogona kuwanikwa kana kuongororwa kweropa kwaitwa chimwe chikonzero. Lymphoplasmacytic lymphoma inowanzopararira kumongo wemapfupa, lymph nodes, uye spleen. Varwere vane lymphoplasmacytic lymphoma vanofanirwa kuongororwa hutachiona hwehepatitis C. Iyo inonzi zvakare Waldenström macroglobulinemia.

Marginal zone lymphoma. Rudzi urwu rweusiri-Hodgkin lymphoma runotanga muB lymphocyte mune chimwe chikamu chemuviri wechiremerwa unonzi marginal zone. Kufungidzira kwacho kunogona kuve kwakanyanya kune varwere vane makore makumi manomwe ekuberekwa kana kupfuura, avo vane chikamu chechitatu kana chegwara IV, uye avo vane yakakwira lactate dehydrogenase (LDH) mazinga. Kune mashanu mashanu akasiyana marginal zone lymphoma. Iwo akabatanidzwa nerudzi rwehuturu uko iyo lymphoma yakaumbwa:

• Nodal marginal zone lymphoma. Nodal marginal zone lymphoma mafomu mune lymph node. Iyi mhando yeiyo isiri Hodgkin lymphoma isingawanzo. Iyo inonziwo monocytoid B-cell lymphoma.

• Gastric mucosa-inosanganisirwa lymphoid tishu (MALT) lymphoma. Gastric MALT lymphoma kazhinji inotanga mudumbu. Iyi mhando yemarginal zone lymphoma mafomu mumasero ari mucosa ayo anobatsira kugadzira masoja ekudzivirira chirwere. Varwere vane gastric MALT lymphoma vanogona zvakare kuva neHelicobacter gastritis kana chirwere chemuviri, senge Hashimoto thyroiditis kana Sjögren syndrome.

• Yakawandisa MALT lymphoma. Extragastric MALT lymphoma inotanga kunze kwedumbu munenge mese mitezo yemuviri kusanganisira zvimwe zvikamu zvegumbo remudumbu, maronda ematehwe, utachiona, mapapu, ganda, uye kutenderedza ziso. Iyi mhando yemarginal zone lymphoma mafomu mumasero ari mucosa ayo anobatsira kugadzira masoja ekudzivirira chirwere. Extragastric MALT lymphoma inogona kudzoka makore mazhinji mushure mekurapwa.

• Mediterranean mudumbu lymphoma. Iyi ndiyo mhando yeMALT lymphoma inowanikwa muvakuru vechidiki kumabvazuva kweMediterranean nyika. Iyo inowanzo kuumba mudumbu uye varwere vanogona zvakare kutapukirwa nehutachiona hunonzi Campylobacter jejuni. Iyi mhando ye lymphoma inonzi zvakare immunoproliferative diki yemukati chirwere.

• Splenic marginal zone lymphoma. Iyi mhando yemahombekombe zone lymphoma inotanga mu spleen uye inogona kupararira kune yeropa reropa uye pfupa remongo. Chiratidzo chakajairika cherudzi urwu rwe splenic marginal zone lymphoma ipleen yakakura kupfuura zvakajairwa.

Yekutanga cutaneous anaplastic hombe cell lymphoma. Mhando iyi isiri-Hodgkin lymphoma iri muganda chete. Inogona kunge iri benign (kwete cancer) nodule iyo inogona kubva yega kana inogona kupararira kunzvimbo zhinji paganda uye inoda kurapwa.

Hutsinye husiri-Hodgkin lymphomas

Kuparadzira yakakura B-cell lymphoma. Kuparadzanisa yakakura B-cell lymphoma ndiyo yakajairika mhando yeiyo isiri Hodgkin lymphoma. Inokura nekukurumidza mune ma lymph node uye kazhinji iyo spleen, chiropa, mwongo wemabhonzo, kana zvimwe nhengo zvinokanganiswawo. Zviratidzo uye zviratidzo zvekupararira kukuru B-cell lymphoma inogona kusanganisira kupisa, kudiridza husiku hwehusiku, uye kuonda. Izvi zvinonziwo zviratidzo zveB.

• Yekutanga mediastinal yakakura B-cell lymphoma. Iyi mhando yeisiri-Hodgkin lymphoma rudzi rwekuparadzira yakakura B-cell lymphoma. Iyo inoratidzirwa nekuwedzera kweye fibrous (scar-like) lymph tishu. Bundu rinowanzo kuumbwa kuseri kwebhonzo rechipfuva. Inogona kumanikidza pamhepo uye inokonzeresa kukosora uye kunetseka kufema. Vazhinji varwere vane main mediastinal makuru B-cell lymphoma vakadzi vane makore makumi matatu kusvika makumi mana.

Follicular yakakura cell lymphoma, danho rechitatu. Follicular yakakura cell lymphoma, nhanho yechitatu, iri mhando isingawanzoitika yeiyo isiri Hodgkin lymphoma. Kurapa kwerudzi urwu rwe follicular lymphoma kwakafanana nekurapwa kweNHL ine hukasha pane yeNole indolent.

Anaplastic yakakura sero lymphoma. Anaplastic hombe cell lymphoma rudzi rweiyo isiri Hodgkin lymphoma iyo inowanzo kutanga muT lymphocytes. Maseru egomarara ane zvakare mucherechedzo unonzi CD30 pamusoro pechitokisi.

Kune maviri marudzi eaplastic hombe cell lymphoma:

• Yakatemwa anaplastic hombe cell lymphoma. Mhando iyi yeaplastic hombe cell lymphoma inonyanya kubata ganda, asi zvimwe zvikamu zvemuviri zvinogona kukanganisika. Zviratidzo zvekucheka kweplastic yakakura cell lymphoma inosanganisira rimwe kana mamwe mapundu kana maronda paganda. Iyi mhando ye lymphoma isingawanzo uye isinganetsi.

• Systemic anaplastic hombe cell lymphoma. Iyi mhando yeaplastic hombe cell lymphoma inotanga mune ma lymph node uye inogona kukanganisa zvimwe zvikamu zvemuviri. Rudzi urwu rwe lymphoma runowedzera hasha. Varwere vanogona kuve nemaprotheni akawanda eplastic lymphoma kinase (ALK) mukati memasero e lymphoma. Ava varwere vane fungidziro iri nani pane varwere vasina mamwe mapuroteni eALK. Systemic anaplastic hombe cell lymphoma yakajairika muvana kupfuura vanhu vakuru. (Ona pfupiso ye paUdiki Isina-Hodgkin Lymphoma Kurapa kuti uwane rumwe ruzivo.)

• Extranodal NK- / T-cell lymphoma. Extranodal NK- / T-cell lymphoma kazhinji inotanga munzvimbo yakatenderedza mhino. Iyo inogona zvakare kukanganisa iyo paranasal sinus (isina mhango nzvimbo mumapfupa akatenderedza mhino), denga remuromo, trachea, ganda, dumbu, uye ura. Mazhinji kesi e extranodal NK- / T-cell lymphoma ane Epstein-Barr hutachiona mumaseru emarara. Dzimwe nguva hemophagocytic syndrome inoitika (yakakomba mamiriro umo mune akawanda kwazvo anoshanda histiocytes uye T maseru anokonzera kuzvimba kwakanyanya mumuviri). Mushonga wekudzvinyirira immune system unodiwa. Iyi mhando yeiyo isiri Hodgkin lymphoma haina kujairika muUnited States.

• Lymphomatoid granulomatosis. Lymphomatoid granulomatosis inonyanya kukanganisa mapapu. Iyo inogona zvakare kukanganisa iyo paranasal sinuses (isina mhango nzvimbo mumapfupa akatenderedza mhino), ganda, itsvo, uye yepakati tsinga system. Mune lymphomatoid granulomatosis, kenza inopinda tsinga dzeropa uye inouraya nyama. Nekuti kenza inogona kupararira ichienda kuuropi, intrathecal chemotherapy kana radiation radiation kuuropi inopihwa.

• Angioimmunoblastic T-cell lymphoma. Iyi mhando yeisiri-Hodgkin lymphoma inotanga mumaT seli. Kuzvimba lymph node chiratidzo chakajairika. Zvimwe zviratidzo zvinogona kusanganisira kuputika kweganda, kupisa muviri, kuonda, kana kudonhedza husiku hwehusiku. Panogona zvakare kuve nemazinga akakwirira egamma globulin (antibodies) muropa. Varwere vanogona zvakare kuve nehutachiona hunotora mukana nekuti ma immune immune avo anoshaiswa simba.

• Peripheral T-cell lymphoma. Peripheral T-cell lymphoma inotanga mukukura T lymphocyte. Rudzi urwu rweT lymphocyte runokura mu thymus gland uye runoenda kune mamwe maLymphatic saiti mumuviri senge ma lymph node, mwongo wemabhonzo, uye spleen. Kune matatu madiki epasi penzvimbo T-cell lymphoma:

• Hepatosplenic T-cell lymphoma. Iyi ndiyo mhando isingawanzoitika yeparutivi T-cell lymphoma inowanikwa kunyanya mumajaya. Inotanga muchiropa uye mudumbu uye maseru egomarara zvakare ane T-cell receptor inonzi gamma / delta pamusoro pechitokisi.

• Subcutaneous panniculitis-senge T-cell lymphoma. Subcutaneous panniculitis-senge T-cell lymphoma inotanga muganda kana mucosa. Izvo zvinogona kuitika nehemophagocytic syndrome (yakakomba mamiriro mune akawanda akawandisa histiocytes uye T maseru anokonzera kuzvimba kwakanyanya mumuviri). Mushonga wekudzvinyirira immune system unodiwa.

• Enteropathy-mhando mudumbu T-cell lymphoma. Mhando iyi yeparutivi T-cell lymphoma inowanikwa mune diki ura hwevarwere vane chisina kurapwa chirwere chechiliac (immune immune mhinduro kune gluten inokonzeresa kushomeka). Varwere vanoonekwa kuti vane chirwere checliac muhucheche uye vanogara pakudya-kusununguka-kashoma havawanzo kuita enteropathy-mhando mudumbu T-cell lymphoma.

• Intravascular hombe B-cell lymphoma. Iyi mhando yeiyo isiri Hodgkin lymphoma inokanganisa mitsipa yeropa, kunyanya iyo midiki midzi yeropa muuropi, itsvo, mapapu uye ganda Zviratidzo uye zviratidzo zveiyo intravascular hombe B-cell lymphoma inokonzerwa nemidziyo yeropa yakavharika. Iyo inonziwo intravascular lymphomatosis.

• Burkitt lymphoma.Burkitt lymphoma rudzi rweB-cell isiri Hodgkin lymphoma inokura nekupararira nekukurumidza. Inogona kukanganisa shaya, mapfupa echiso, ura, itsvo, ovari, kana dzimwe nhengo. Kune matatu makuru marudzi eBurkitt lymphoma (endemic, sporadic, uye immunodeficiency inoenderana). Endemic Burkitt lymphoma inowanzoitika muAfrica uye yakabatana nehutachiona hweEpstein-Barr, uye zvisingaite Burkitt lymphoma inoitika pasirese. Immunodeficiency-related Burkitt lymphoma inowanzoonekwa kune varwere vane AIDS. Burkitt lymphoma inogona kupararira kuuropi uye musana uye kurapwa kudzivirira kupararira kwayo kunogona kupihwa. Burkitt lymphoma inoitika kazhinji muvana nevakuru vechidiki (Ona pfupiso ye paChidiki Isiri-Hodgkin Lymphoma Kurapa kuti uwane rumwe ruzivo.) Burkitt lymphoma inonzi zvakare inoparadzira diki isina kujekesa-cell lymphoma.

• Lymphoblastic lymphoma. Lymphoblastic lymphoma inogona kutanga mumasero eT kana B masero, asi kazhinji inotanga mumaT seli. Mune irwo rudzi rweusiri-Hodgkin lymphoma, kune ma lymphoblast akawandisa (asina kuchena maseru eropa) mune ma lymph node uye thymus gland. Aya ma lymphoblast anogona kupararira kune dzimwe nzvimbo mumuviri, senge mongo wepfupa, huropi, uye musana. Lymphoblastic lymphoma inowanzoitika kune vechidiki nevakuru vechidiki. Izvo zvakafanana neacute lymphoblastic leukemia (maLymphoblast anowanikwa zvakanyanya mumapfupa uye muropa). (Ona pfupiso ye pamusoro peVakuru Acute Lymphoblastic Leukemia Kurapa kuti uwane rumwe ruzivo.)

• Mukuru T-cell leukemia / lymphoma. Mukuru T-cell leukemia / lymphoma inokonzerwa nehunhu T-cell leukemia hutachiona hwerudzi 1 (HTLV-1). Zviratidzo zvinosanganisira mapfupa neganda maronda, akakwira ropa calcium calcium, uye lymph node, spleen, uye chiropa izvo zvakakura kupfuura zvakajairwa.

• Mantle sero lymphoma. Mantle cell lymphoma rudzi rweB-cell isiri Hodgkin lymphoma iyo inowanzoitika kune vane makore ari pakati nepakati kana vakuru. Inotanga mune node uye inopararira kune spleen, mwongo wemapfupa, ropa, uye dzimwe nguva hosha, mudumbu uye ura. Varwere vane mantle cell lymphoma vane yakawandisa mapuroteni anonzi cyclin-D1 kana imwe geni shanduko mumasero e-lymphoma. Mune vamwe varwere vasina zviratidzo kana zviratidzo zve lymphoma kunonoka kutanga kwekurapa hakukanganisa kufungidzira.

• Posttransplantation lymphoproliferative kusagadzikana. Ichi chirwere chinoitika kune varwere vane moyo, mapapu, chiropa, itsvo, kana pancreas kuisirwa uye vanoda kwehupenyu hwese immune immunosuppressive therapy. Mazhinji posttransplant lymphoproliferative kusagadzikana anokanganisa masero eB uye ane Epstein-Barr hutachiona mumasero. Zvirwere zveLymphoproliferative zvinowanzo kurapwa sekenza.

• Chokwadi histiocytic lymphoma. Ichi hachiwanzo, chine hukasha rudzi rwe lymphoma. Hazvizivikanwe kuti inotanga mumasero eB kana masero eT. Izvo hazvipindure mushe pakurapwa neyakajairwa chemotherapy.

• Primary effusion lymphoma. Primary effusion lymphoma inotangira mumasero B anowanikwa munzvimbo ine hombe yekuvaka mvura, senzvimbo dziri pakati pechigadziko chemapapu uye chipfuva (pleural effusion), saga rakakomberedza moyo nemoyo (pericardial effusion), kana mudumbu. Kazhinji hapana bundu rinoonekwa. Rudzi urwu rwe lymphoma runowanzoitika kune varwere vane hutachiona hweHIV.

• Plasmablastic lymphoma. Plasmablastic lymphoma rudzi rweB-cell hombe isiri Hodgkin lymphoma ine hukasha. Inowanzoonekwa kune varwere vane hutachiona hweHIV.

Kuchembera, kuve murume, uye kuve nehutachiona hwemuviri kunogona kuwedzera njodzi yevakuru vasiri-Hodgkin lymphoma.

Chero chipi zvacho chinowedzera njodzi yako yekuwana chirwere chinonzi njodzi chinhu. Kuva nenjodzi hazvireve kuti uchawana gomarara; kusava nenjodzi hazvireve kuti hauzobatwe negomarara. Taura nachiremba wako kana iwe uchifunga kuti ungave uri panjodzi.

Izvi uye zvimwe zvinenjodzi zvinogona kuwedzera njodzi yemamwe marudzi evakuru vasiri-Hodgkin lymphoma:

• Kuva mukuru, murume, kana chena.

• Kuva nechimwe cheanotevera mamiriro ekurapa anoderedza immune system:

• Chirwere chekuzvidzivirira kubva kuzvirwere (zvakadai se hypogammaglobulinemia kana Wiskott-Aldrich syndrome).

• Chirwere chekuzvimiririra (senge rheumatoid arthritis, psoriasis, kana Sjögren syndrome).

• HIV / AIDS.

• Yevanhu T-lymphotrophic hutachiona mhando I kana Epstein-Barr hutachiona hutachiona.

• Helicobacter pylori hutachiona.

• Kutora immunosuppressant zvinodhaka mushure mekuiswa kwechimwe nhengo.

Zviratidzo nezviratidzo zvevakuru vasiri-Hodgkin lymphoma zvinosanganisira kuzvimba lymph node, fivha, kunwisa kudikitira usiku, kupera muviri, uye kuneta.

Izvi zviratidzo nezviratidzo zvinogona kukonzerwa nevakuru vasiri-Hodgkin lymphoma kana nemamwe mamiriro. Tarisa nachiremba wako kana iwe uine chero chinotevera:

• Kuzvimba mune ma lymph node mumutsipa, underarm, kugomera, kana mudumbu.

• Fivha pasina chikonzero chinozivikanwa.

• Kunwisa usiku ziya.

• Kunzwa kuneta chaizvo.

• Kurera huremu pasina chikonzero chinozivikanwa.

• Kuputika kweganda kana ganda rinonamira.

• Marwadzo mubhokisi, mudumbu, kana mapfupa pasina chikonzero chinozivikanwa.

• Kana fivha, kunwisa kudikitira husiku, uye kuonda zvichiitika pamwechete, iri boka rezviratidzo rinonzi B zviratidzo.

Zvimwe zviratidzo nezviratidzo zvevakuru vasiri-Hodgkin lymphoma zvinogona kuitika uye zvinoenderana nezvinotevera:

• Ikoko uko kenza inoumba mumuviri.

• Kukura kwebundu.

• Kurumidza sei bundu kukura.

Kuyedza kunoongorora iyo lymph system uye zvimwe zvikamu zvemuviri zvinoshandiswa kubatsira kuongorora uye kuyera vakuru vasina-Hodgkin lymphoma.

Iyi inotevera bvunzo uye maitiro anogona kushandiswa:

• Kuongorora kwemuviri uye nhoroondo yehutano: Kuongororwa kwemuviri kutarisa zviratidzo zvehutano, kusanganisira kuongorora zviratidzo zvehosha, zvakadai semapundu kana chero chinhu chinoratidzika sechisina kujairika. Nhoroondo yehutano hwemurwere, kusanganisira kupisa muviri, kudikitira usiku, uye kuonda, tsika dzehutano, nezvirwere zvekare uye kurapwa kuchatorwawo.

• Yakazara kuverenga kweropa (CBC): Maitiro umo muyenzaniso weropa unodhonzwa nekuongororwa zvinotevera:

• Huwandu hwemasero matsvuku eropa, machena masero eropa, uye maplatelet.

• Huwandu hwehemoglobin (protein inotakura oxygen) mumasero matsvuku eropa.

• Chikamu chemuenzaniso chakaumbwa nemasero matsvuku eropa.

Yakazara kuverenga ropa (CBC). Ropa rinounganidzwa nekupinza tsono mutsinga uye richiita kuti ropa riyerere muhubhu. Muenzaniso weropa unotumirwa murabhoritari uye masero matsvuku eropa, masero machena eropa, uye maplatelet anoverengwa. Iyo CBC inoshandiswa kuyedza, kuongorora, uye kuongorora akawanda mamiriro akasiyana.

• Ropa kemesitiri zvidzidzo: Maitiro umo muyedzo weropa unoongororwa kuyera huwandu hwezvimwe zvinhu zvakaburitswa muropa nenhengo uye nyama munyama. Chinhu chisina kujairika (chakakwirira kana chakaderera pane zvakajairwa) chiyero chechinhu chinogona kunge chiri chiratidzo chechirwere.

• LDH bvunzo: Maitiro umo muyedzo weropa unotariswa kuyera huwandu hweiyo lactic dehydrogenase. Yakawedzera huwandu hweLDH muropa inogona kunge iri chiratidzo chekukuvara kwetishu, lymphoma, kana zvimwe zvirwere.

• Hepatitis B uye hepatitis C bvunzo: Maitiro umo muyenzaniso weropa unoongororwa kuyera huwandu hwehutachiona hweH hepatitis B hutachiona-uye maanti antibodies uye huwandu hwehutachiona hweH hepatitis C hutachiona. Aya maantigen kana ma antibodies anonzi mamaki. Zviratidzo zvakasiyana kana mubatanidzwa wezviratidzo zvinoshandiswa kuona kuti murwere ane hutachiona hwehepatitis B kana C, akambotapukirwa kana kubayiwa nhomba, kana kuti anogona kubatwa nehutachiona. Varwere vakamborapwa hutachiona hwehepatitis B munguva yakapfuura vanoda kuenderera mberi vachiongorora kuti vaone kana yamukazve. Kuziva kuti munhu ane hepatitis B kana C kunogona kubatsira kuronga kurapwa.

• HIV bvunzo: Chiyero chekuyera huwandu hweanodzivirira hutachiona hweHIV mune muyenzaniso weropa. Maantibodies anogadzirwa nemuviri kana uchinge wapindwa nechinhu chekunze. Chikamu chepamusoro chemasoja ekudzivirira Mukondombera zvinogona kureva kuti muviri watapukirwa neHIV.

• CT scan (CAT scan): Maitiro anoita akateedzana emifananidzo yakajeka yenzvimbo dziri mukati memuviri, senge mutsipa, chifuva, dumbu, pelvis, uye lymph node, inotorwa kubva kumakona akasiyana. Mifananidzo yacho inogadzirwa nekombuta yakabatana neiyo x-ray muchina. Dhayi inogona kuiswa jekiseni kana kumedzwa kubatsira nhengo kana zvinyama kuratidza zvakajeka. Iyi nzira inonziwo computed tomography, computerized tomography, kana komputa axial tomography.

• PET scan (positron emission tomography scan): Iyo nzira yekuwana yakaipa malonda maseru mumuviri. Chishoma che radioactive glucose (shuga) inoiswa mutsinga. Iyo PET scanner inotenderera yakatenderedza muviri uye inogadzira mufananidzo wepo glucose iri kushandiswa mumuviri. Malignant tumarara maseru anoratidza kupenya mumufananidzo nekuti anoshanda uye anotora glucose yakawanda kupfuura zvinoita maseru akajairwa.

• Bone marrow aspiration uye biopsy: Kubviswa kwemongo wefupa uye chidimbu chefupa nekuisa tsono muchiuno kana pfupa rechipfuva. Nyanzvi yezvirwere anoona pfupa nemabhonzo pasi pe microscope kutsvaga zviratidzo zvecancer.

Bone marora chishuwo uye biopsy. Mushure mekunge nzvimbo diki yeganda yave nechiveve, tsono yemongo wemapfupa inoiswa mupfupa rehudyu remurwere. Samples reropa, bhonzo, uye mwongo wemapfupa zvinobviswa kuti zviongororwe pasi pe microscope.

• Lymph node biopsy: Kubviswa kwezvose kana chikamu chema lymph node. Nyanzvi yezvirwere anoona tishu pasi pe microscope kuti aongorore masero ekenza. Imwe yedzinotevera mhando dze biopsies dzinogona kuitwa:

• Excisional biopsy: Kubviswa kweiyo lymph node.

• Incisional biopsy: Kubviswa kwechikamu chema lymph node.

• Core biopsy: Kubviswa kwechikamu chema lymph node uchishandisa yakafara tsono.

Kana gomarara rikawanikwa, bvunzo dzinotevera dzinogona kuitwa kuongorora maseru ekenza:

• Immunohistochemistry: Kuongororwa kwerabhoritari inoshandisa masoja ekudzivirira mamwe maantigen (mamaki) mune imwe sampuro yetishu yemurwere. Masoja ekudzivirira chirwere anowanzo sunganidzwa ne enzyme kana dhayi ye fluorescent. Mushure mekunge maantibodies akasunga kune yakasarudzika antigen mune yeiyo sampuli, iyo enzyme kana dhayi inoitwa, uye iyo antigen inogona kuzoonekwa pasi pe microscope. Rudzi urwu rweyedzo runoshandiswa kubatsira kuongorora gomarara uye kubatsira kutaurira imwe mhando yekenza kubva kune imwe mhando yegomarara.

• Kuongorora kweCytogenetic: Kuongororwa kwerabhoritari umo ma chromosomes emaseru mune muyenzaniso weropa kana mongo wemapfupa anoverengwa uye kuongororwa chero shanduko, sekutyorwa, kushaikwa, kurongedzwa patsva, kana mamwe ma chromosomes. Shanduko mune mamwe ma chromosomes inogona kunge iri chiratidzo checancer. Kuongorora kweCytogenetic kunoshandiswa kubatsira kuongorora cancer, kuronga kurapwa, kana kuona kuti kurapa kuri kushanda sei.

• Immunophenotyping: Kuongororwa kwerabhoritari inoshandisa masoja ekudzivirira kenza maseru zvichibva pamhando dzemaantigen kana mamaki ari pamusoro pemasero. Uyu muedzo unoshandiswa kubatsira kuongorora chaiwo marudzi e lymphoma.

• FISH (fluorescence in situ hybridization): Kuedzwa kwerabhoritari kunoshandiswa kutarisa uye kuverenga majeni kana ma chromosomes mumasero nematukisi. Zvidimbu zveDNA zvine dhayi ye fluorescent zvinogadzirwa murabhoritari uye zvinowedzerwa kune imwe sampuli yemasero emurwere kana zvinyama. Kana zvidimbu izvi zvakavezwa zveDNA zvonamatira kune mamwe mageneti kana nzvimbo dzekromosomes mumuenzaniso, dzinovhenekera kana dzatariswa pasi pefluorescent microscope. Chiyero cheFISH chinoshandiswa kubatsira kuongorora kenza uye kubatsira kuronga kurapwa.

Mimwe bvunzo nemaitiro zvinogona kuitwa zvichienderana nezviratidzo nezviratidzo zvinoonekwa uye panowanikwa kenza mumuviri.

Zvimwe zvinhu zvinokanganisa kufungidzira (mukana wekupora) uye sarudzo dzekurapa.

Kufungidzira uye sarudzo dzekurapa dzinoenderana nezvinotevera:

• Zviratidzo uye zviratidzo zvevarwere, zvinosanganisira kana vasina B zviratidzo (fivha pasina chikonzero chinozivikanwa, kurasikirwa uremu pasina chikonzero chinozivikanwa, kana kunwisa ziya rehusiku).

• Chikamu checancer (saizi yemamota ekenza uye kana gomarara rapararira kune dzimwe nhengo dzomuviri kana node dzenhengo).

• Mhando yeiyo isiri-Hodgkin lymphoma.

• Huwandu hwe lactate dehydrogenase (LDH) muropa.

• Kunyangwe paine zvimwe zvinoshanduka mumajini.

• Zera remurwere, bonde, uye hutano huzhinji.

• Kunyangwe iyo lymphoma ichangobva kuongororwa, inoramba ichikura panguva yekurapa, kana yakadzoka (dzoka).

Kune isiri-Hodgkin lymphoma panguva yekuzvitakura, sarudzo dzekurapa dzinoenderanawo ne:

• Izvo zvishuwo zvemurwere.

• Ndeipi trimester yepamuviri iyo murwere ari.

• Kunyangwe mwana anogona kusununguka nekukurumidza.

Dzimwe mhando dzisiri-Hodgkin lymphoma inopararira nekukurumidza kupfuura zvinoita vamwe. Mazhinji asiri eHodgkin lymphomas anoitika panguva yekuzvitakura ane hasha. Kunonoka kurapwa kwehasha lymphoma kusvikira mushure mekuzvarwa kwemwana kunogona kudzikisira mukana waamai kupona. Kurapa kwekukurumidza kunowanzo kurudzirwa, kunyangwe panguva yekuzvitakura.

Matanho eVakuru Asiri-Hodgkin Lymphoma

PFUNGWA DZINOKOSHA

• Mushure mokunge munhu mukuru asiri Hodgkin lymphoma aonekwa, miedzo inoitwa kuti uone kana kenza maseru akapararira mukati meiyo lymph system kana kune zvimwe zvikamu zvemuviri.

• Pane nzira nhatu dzinopararira negomarara mumuviri.

• Aya matanho anotevera anoshandiswa kune vakuru vasiri-Hodgkin lymphoma:

• Chikamu I

• Chikamu II

• Chikamu chechitatu

• Chikamu IV

• Kudzokorora Kwevakuru Asiri-Hodgkin Lymphoma

• Vakuru vasiri-Hodgkin lymphomas vanogona kuunganidzwa kuti varapwe zvinoenderana nekuti kenza haina kusimba here kana kuti ine hukasha, ingave inokanganisa lymph node iri padhuze nepadhuze nemuviri, uye kana gomarara richangobva kuongororwa kana kudzokororwa.

Mushure mokunge munhu mukuru asiri Hodgkin lymphoma aonekwa, miedzo inoitwa kuti uone kana kenza maseru akapararira mukati meiyo lymph system kana kune zvimwe zvikamu zvemuviri.

Maitiro anoshandiswa kutsvaga mhando yegomarara uye kana gomarara maseru apararira mukati meiyo lymph system kana kune mamwe mativi emuviri anonzi staging. Ruzivo rwakaunganidzwa kubva munzira yekugadzwa rinotara danho rechirwere. Izvo zvakakosha kuti uzive nhanho yechirwere kuitira kuronga kurapwa. Mhedzisiro yemiyedzo uye maitiro akaitwa kuti aongorore asiri Hodgkin lymphoma anoshandiswa kubatsira kuita sarudzo nezvekurapa.

Aya anotevera bvunzo nemaitiro anogona zvakare kushandiswa mune yekuratidzira maitiro:

• MRI (magnetic resonance imaging) ine gadolinium: Maitiro anoshandisa magineti, masaisai eredhiyo, uye komputa kugadzira yakateedzana mifananidzo yakajeka yenzvimbo dziri mukati memuviri, senge huropi uye musana. Chinhu chinonzi gadolinium chinojowa mumurwere kuburikidza netsinga. Iyo gadolinium inounganidza yakatenderedza maseru ekenza kuitira kuti varatidze kupenya mumufananidzo. Iyi nzira inonziwo nyukireya magnetic resonance imaging (NMRI).

• Lumbar puncture: Maitiro anoshandiswa kutora cerebrospinal fluid (CSF) kubva pamutsipa wepelinha. Izvi zvinoitwa nekuisa tsono pakati pemabhonzo maviri mumuzongoza nekupinda muCSF yakakomberedza musana uye kubvisa sampu yemvura. Muenzaniso weCSF unotariswa pasi pe microscope yezviratidzo zvekuti gomarara rapararira kuuropi uye musana. Maitiro aya anonzi zvakare LP kana musana tap.

Lumbar kubaya. Murwere akarara panzvimbo yakamonana patafura. Mushure mekunge diki nzvimbo kumucheto kumashure yave chiveve, tsono yemusana (tsono refu, nhete) inoiswa muchikamu chezasi chepamuviri mbichana kubvisa cerebrospinal fluid (CSF, inoratidzwa mublue). Mvura yacho inogona kutumirwa kurabhoritari kunoongororwa.

Kune vakadzi vane nhumbu vasina-Hodgkin lymphoma, bvunzo dzekuyera uye maitiro anodzivirira mwana asati aberekwa kubva kukuvadzwa nemwaranzi zvinoshandiswa Iyi bvunzo uye maitiro anosanganisira MRI (pasina musiyano), lumbar puncture, uye ultrasound.

Pane nzira nhatu dzinopararira negomarara mumuviri. Kenza inogona kupararira kuburikidza nematinji, iyo lymph system, uye neropa:

• Tishu. Kenza inopararira kubva kwayakatanga nekukura ichipinda munzvimbo dziri pedyo.

• Lymph maitiro. Kenza inopararira kubva kwayakatanga nekupinda muiyo lymph system. Kenza inofamba nemumidziyo yema lymph ichienda kune dzimwe nhengo dzemuviri.

• Ropa. Kenza inopararira kubva payakatanga nekupinda muropa. Kenza inofamba nemidzi yeropa ichienda kune dzimwe nhengo dzemuviri.

Aya matanho anotevera anoshandiswa kune vakuru vasiri-Hodgkin lymphoma:

Chikamu I

Chikamu ini munhu mukuru lymphoma. Gomarara rinowanikwa mune imwe kana anopfuura mamwe ma "lymph node" muboka rema "lymph node" kana, mune zvisingawanzoitika, kenza inowanikwa mhete yeWaldeyer, thymus, kana spleen. Muchikamu IE (isina kuratidzwa), gomarara rapararira kune imwe nzvimbo kunze kweiyo lymph system.

Chikamu I mukuru asiri Hodgkin lymphoma yakakamurwa muzvikamu ini neIE.

Muchikamu ini, kenza inowanikwa mune imwe yenzvimbo dzinotevera mune lymph system:

• Imwe kana anopfuura mamwe ma lymph node muboka rema lymph node.

• Mhete yaWaldeyer.

• Thymus.

• Spleen.

Muchikamu IE, kenza inowanikwa mune imwe nharaunda kunze kweiyo lymph system.

Chikamu II

Chikamu chechipiri II chisina-Hodgkin lymphoma chakakamurwa muzvikamu II uye IIE.

• Muchikamu chechipiri, kenza inowanikwa mumapoka maviri kana anopfuura emakemikari mairi ari pamusoro pechidziro kana pazasi pechidzitiro.

Chikamu II munhu mukuru lymphoma. Gomarara rinowanikwa mune maviri kana anopfuura mapoka ema lymph node ayo ari pamusoro pechirafu kana pazasi pechirafu.

• Muchikamu IIE, kenza yakapararira kubva kuboka rema lymph node kuenda kunzvimbo iri padyo iri kunze kwenzira yema lymph. Kanzera inogona kunge yakapararira kune mamwe ma lymph node mapoka kudivi rimwe reiyo diaphragm.

Chikamu IIE munhu mukuru lymphoma. Kenza yapararira kubva kuboka rema lymph node kuenda kunzvimbo iri padyo iri kunze kwenzira yema lymph. Kanzera inogona kunge yakapararira kune mamwe ma lymph node mapoka kudivi rimwe reiyo diaphragm.

Muchikamu chechipiri, izwi rekuti bulky chirwere rinoreva hombe kukura. Hukuru hwehuturu hunorehwa hunonzi chirwere chakakura hunosiyana zvichienderana nerudzi rwe lymphoma.

Chikamu chechitatu

Chikamu chechitatu munhu mukuru lymphoma. Gomarara rinowanikwa mumapoka ema lymph node ese ari pamusoro nepazasi peya diaphragm; kana muboka rema lymph node pamusoro pechirafu uye mupleen.

Muchikamu chechitatu munhu mukuru asiri Hodgkin lymphoma, kenza inowanikwa:

• mumapoka ema lymph node kumusoro nekuzasi kwedhayaphirafu; kana

• mune lymph nodes pamusoro pechipfuva uye mupleen.

Chikamu IV

Chikamu IV munhu mukuru lymphoma. Gomarara (a) rakapararira mukati memumwe kana anopfuura nhengo kunze kwenzira yemajuku; kana (b) inowanikwa mumapoka maviri kana anopfuura emakiropu ari pamusoro pechirafu kana pazasi pechidhiraivho uye mune imwe nhengo iri kunze kwenzira uye isiri pedyo nenhengo dzakakanganiswa; kana (c) inowanikwa mumapoka enhengo dzenzamu pamusoro peya diaphragm uye pazasi pechidhiramu nechero nhengo iri kunze kwetsinga; kana (d) inowanikwa muchiropa, mwongo wemabhonzo, nzvimbo dzinopfuura imwechete mumapapu, kana cerebrospinal fluid (CSF). Kenza haina kupararira yakananga muchiropa, mwongo wemapfupa, mapapu, kana CSF kubva kuma lymph node ari padyo.

Muchikamu IV munhu mukuru asiri Hodgkin lymphoma, cancer.

• yakapararira mukati memumwe kana akawanda nhengo kunze kwenzvimbo yemajukunzi; kana

• inowanikwa mumapoka maviri kana anopfuura emakirini mairi anenge ari pamusoro pechipfuva kana pasi pechidimbu uye mune imwe nhengo iri kunze kwenzvimbo yema lymph uye kwete padhuze nema lymph node akakanganiswa; kana

• inowanikwa mumapoka ema lymph node ese ari pamusoro uye pazasi peya diaphragm uye mune chero nhengo iri kunze kweiyo lymph system; kana

• inowanikwa muchiropa, pfupa remongo, nzvimbo dzinopfuura imwechete mumapapu, kana cerebrospinal fluid (CSF). Kenza haina kupararira yakananga muchiropa, mwongo wemapfupa, mapapu, kana CSF kubva kuma lymph node ari padyo.

Kudzokorora Kwevakuru Asiri-Hodgkin Lymphoma

Kazhinji munhu mukuru asiri Hodgkin lymphoma kenza yakadzokazve (yadzoka) mushure mekurapwa. Iyo lymphoma inogona kudzoka muiyo lymph system kana mune zvimwe zvikamu zvemuviri. Indolent lymphoma inogona kudzoka ine hukasha lymphoma. Aggressive lymphoma inogona kudzoka seindolent lymphoma.

Vakuru vasiri-Hodgkin lymphomas vanogona kuunganidzwa kuti varapwe zvinoenderana nekuti kenza haina kusimba here kana kuti ine hukasha, ingave inokanganisa lymph node iri padhuze nepadhuze nemuviri, uye kana gomarara richangobva kuongororwa kana kudzokororwa.

Ona iyo General Ruzivo chikamu cherumwe ruzivo nezve mhando dze indolent (inononoka-kukura) uye ine hukasha (inokurumidza kukura) isiri-Hodgkin lymphoma.

Asiri-Hodgkin lymphoma inogona zvakare kutsanangurwa seyakaganhurana kana isinganetsi:

• Inoenderana lymphomas: Lymphomas mune iyo lymph node nekenza iri padhuze nepadhuze.

• Noncontiguous lymphomas: MaLymphomas umo maLymph node ane gomarara haasi padhuze nepadhuze, asi ari kudivi rimwe rechidimbu.

Kurapa Sarudzo Kuongorora

PFUNGWA DZINOKOSHA

• Kune akasiyana marudzi ekurapa kwevarwere vasina-Hodgkin lymphoma.

• Varwere vasina-Hodgkin lymphoma vanofanirwa kurapwa kwavo kuchirongwa nechikwata chevanoona nezvehutano vari nyanzvi mukurapa

• lymphomas.

• Kurapa kwevanhu vakuru vasiri-Hodgkin lymphoma kunogona kukonzera mhedzisiro.

• Radiation kurapa

• Chemotherapy

• Immunotherapy

• Targeted kurapwa

• Plasmapheresis

• Kurinda kumirira

• Mishonga inorwisa mabhakitiriya

• Kuvhiya

• Stem cell kuisirwa

• Mhando nyowani dzekurapa dziri kuyedzwa mumakiriniki ekuedzwa.

• Mushonga wekudzivirira

• Varwere vangangoda kufunga nezve kutora chikamu mukutora kiriniki.

• Varwere vanogona kupinda mumakiriniki miedzo vasati, panguva, kana mushure mekutanga kwavo kenza kurapwa.

• Yekutevera-bvunzo inogona kudikanwa.

Kune akasiyana marudzi ekurapa kwevarwere vasina-Hodgkin lymphoma.

Mhando dzakasiyana dzekurapa dziripo kune varwere vasina-Hodgkin lymphoma. Mamwe marapirwo akajairwa (iko kurapwa kwazvino kwashandiswa), uye kumwe kuedzwa mumakiriniki ekuedzwa A kurapwa kiriniki kuyedzwa chidzidzo chekutsvaga chakaitirwa kubatsira kuvandudza marapirwo azvino kana kuwana ruzivo marapirwo matsva evarwere vane gomarara. Kana kiriniki miedzo ikaratidza kuti kurapwa kutsva kuri nani pane kwese kurapwa, kurapwa kutsva kunogona kuve kwakajairwa kurapwa. Varwere vangangoda kufunga nezve kutora chikamu mukutora kiriniki. Mimwe miedzo yekiriniki yakavhurwa chete kune varwere vasina kutanga kurapwa.

Kune vakadzi vane nhumbu vasina-Hodgkin lymphoma, kurapwa kwakanyatsosarudzwa kuchengetedza mwana asati aberekwa. Kurapa sarudzo kunoenderana nezvido zvaamai, danho reiyo isiri-Hodgkin lymphoma, uye zera remwana asati azvarwa. Chirongwa chekurapa chinogona kuchinja sezvo zviratidzo nezviratidzo, gomarara, uye nhumbu kuchinja. Kusarudza kurapwa kwakakodzera kwekenza chisarudzo icho chinosanganisira timu yevarwere, yemhuri, uye yehutano.

Varwere vasina-Hodgkin lymphoma vanofanirwa kurapwa kurapwa nechikwata chevanoona nezvehutano vari nyanzvi mukurapa lymphomas.

Kurapa kunozo chengetedzwa nachiremba oncologist, chiremba ane hunyanzvi hwekurapa kenza, kana hematologist, chiremba ane hunyanzvi hwekurapa kenza yeropa. Wekurapa oncologist anogona kukuendesa kune vamwe vatapi vezvehutano vane ruzivo uye vari nyanzvi mukurapa vakuru vasiri-Hodgkin lymphoma uye vanoziva mune dzimwe nzvimbo dzemishonga. Izvi zvinogona kusanganisira vanachiremba vanotevera:

• Neurosurgeon.

• Neurologist.

• Radiation oncologist.

• Endocrinologist.

• Rehabilitation nyanzvi.

• Vamwe vezve oncology nyanzvi.

Kurapa kwevanhu vakuru vasiri-Hodgkin lymphoma kunogona kukonzera mhedzisiro.

Kuti uwane ruzivo nezve mhedzisiro inotanga panguva yekurapa kenza, ona yedu Side Mhedzisiro peji.

Zvimwe zvinokonzeresa kubva pakurapwa nekenza zvinotanga mushure mekurapwa uye kuenderera kwemwedzi kana makore zvinonzi kunonoka kuitika Kurapa nekemotherapy, radiation radiation, kana stem cell yekuisira kune isiri-Hodgkin lymphoma inogona kuwedzera njodzi yekupedzisira mhedzisiro.

Mhedzisiro mhedzisiro yekurapwa nekenza inogona kusanganisira zvinotevera:

• Zvinetso zvemwoyo.

• Kushaya mbereko (kutadza kuita vana).

• Kurasikirwa kwepfupa.

• Neuropathy (kukuvara kwetsinga kunokonzera kupera simba kana kunetseka kufamba).

• Kenza yechipiri, yakadai se:

• Kenza yemapapu.

• Gomarara repfungwa.

• Kenza yeitsvo.

• Gomarara redundira.

• Melanoma.

• Hodgkin lymphoma.

• Myelodysplastic chirwere.

• Acute myeloid leukemia.

Mimwe mhedzisiro mhedzisiro inogona kurapwa kana kudzorwa. Izvo zvakakosha kuti utaure nachiremba wako nezve mhedzisiro yekurapwa nekenza kunogona kuve pauri. Kugara uchitevera-kutarisa kuti unonoke mhedzisiro kwakakosha.

Mhando mipfumbamwe yekurapa kwakajairika inoshandiswa:

Radiation kurapa

Radiation kurapa kurapwa kenza iyo inoshandisa yakakwira-simba x-rays kana mamwe marudzi e radiation kuuraya cancer maseru kana kuachengeta iwo kuti asakure.

External radiation therapy inoshandisa muchina uri kunze kwemuviri kutumira radiation kune iyo nzvimbo yemuviri nekenza. Dzimwe nguva yakazara-muviri irradiation inopihwa pasati padzika masero ekuisira.

Proton beam radiation radiation inoshandisa hova dzemapurotoni (zvidimbu zvidiki zvinechaji yakanaka) kuuraya tumarara maseru. Rudzi urwu rwekurapa runogona kudzikisa huwandu hwekukuvara kwemwaranzi kumatishu ane hutano padhuze nebundu, senge moyo kana zamu.

External radiation therapy inoshandiswa kurapa vanhu vakuru vasiri-Hodgkin lymphoma, uye inogona zvakare kushandiswa senge palliative kurapwa kubvisa zviratidzo uye nekuvandudza hupenyu hwehupenyu.

Kune mukadzi ane nhumbu asina-Hodgkin lymphoma, kurapwa kwemwaranzi kunofanirwa kupihwa mushure mekusununguka, kana zvichibvira, kudzivirira chero njodzi kumwana asati aberekwa. Kana kurapwa kuchidikanwa ipapo, mukadzi anogona kusarudza kuenderera nepamuviri uye nekugamuchira kurapwa nemwaranzi. Nhoo inotungamira inoshandiswa kuvhara dumbu remukadzi ane nhumbu kubatsira kudzivirira mwana asati azvarwa kubva kumwaranzi zvakanyanya sezvinobvira.

Chemotherapy

Chemotherapy mushonga wekenza unoshandisa mishonga kumisa kukura kwemasero ekenza, kungave nekuuraya maseru kana nekuamisa iwo kubva pakupatsanuka. Kana chemotherapy ikatorwa nemuromo kana kujowa mutsinga kana mhasuru, mishonga inopinda muropa uye inogona kusvika masero emukenza mumuviri wese (systemic chemotherapy). Kana chemotherapy ikaiswa yakanangana necerebrospinal fluid (intrathecal chemotherapy), nhengo, kana dumbu remuviri senge dumbu, mishonga inonyanya kukanganisa maseru ekenza munzvimbo idzodzo (chemotherapy yedunhu). Kubatanidzwa chemotherapy kurapwa kunoshandisa maviri kana anopfuura anticancer zvinodhaka. Steroid zvinodhaka zvinogona kuwedzerwa, kudzikisira kuzvimba uye kudzikisa immune mhinduro yemuviri.

Systemic mubatanidzwa chemotherapy inoshandiswa pakurapa kwevanhu vakuru vasiri-Hodgkin lymphoma.

Intrathecal chemotherapy inogona zvakare kushandiswa pakurapa lymphoma inotanga kuumbika mumachende kana muzvitadzo (nzvimbo dzine mhango) dzakakomberedza mhino, inoparadzira yakakura B-cell lymphoma, Burkitt lymphoma, lymphoblastic lymphoma, uye imwe ine hasha T-cell lymphomas. Iyo inopihwa kudzikisira mukana wekuti lymphoma maseru apararire kuuropi uye musana. Izvi zvinonzi CNS prophylaxis.

Intrathecal chemotherapy. Anticancer zvinodhaka zvinopinda mukati meiyo intrathecal nzvimbo, inova iyo nzvimbo inobata iyo cerebrospinal fluid (CSF, inoratidzwa mublue). Pane nzira mbiri dzakasiyana dzekuita izvi. Imwe nzira, inoratidzwa muchikamu chepamusoro chemufananidzo, kuisa majekiseni mumugodhi weOmaya (mudziyo wakaita sedome wakaiswa pasi peganda panguva yekuvhiyiwa; inobata mishonga painenge ichiyerera nepombi diki ichienda muuropi ). Imwe nzira, inoratidzwa muchikamu chepazasi chemufananidzo, kupinza mishonga yakananga muCSF muchikamu chepazasi chechipenga chemusana, mushure mekunge nzvimbo diki kumusana wezasi yave nechiveve.

Kana mukadzi ane nhumbu achirapwa nekemotherapy kune asiri Hodgkin lymphoma, mwana asati azvarwa haagoni kudzivirirwa kubva pakuratidzirwa kune chemotherapy. Dzimwe chemotherapy regimens dzinogona kukonzera kuremara kwekuzvarwa kana ikapihwa mune yekutanga trimester.

Ona Zvinodhaka Zvinotenderwa kune Asiri-Hodgkin Lymphoma kuti uwane rumwe ruzivo.

Immunotherapy

Immunotherapy kurapwa kunoshandisa immune system yemurwere kurwisa gomarara. Zvinhu zvinogadzirwa nemuviri kana kugadzirwa murabhoritari zvinoshandiswa kusimudzira, kunongedza, kana kudzorera kudzivirira kwemuviri kurwisa kenza. Immunomodulators uye CAR T-cell kurapa ndiwo marudzi eununotherapy.

• Immunomodulators: Lenalidomide inonzi immunomodulator inoshandiswa kurapa munhu mukuru asiri Hodgkin lymphoma.

• CAR T-cell kurapa: T yemurwere T masero (rudzi rwe immune system maseru) anochinjwa saka ivo vanozorwisa mamwe mapuroteni pamusoro pekenza maseru. T maseru anotorwa kubva kumurwere uye akakosha maakagamuchirwa anowedzerwa kumusoro kwawo murabhoritari. Masero akachinjwa anonzi chimeric antigen receptor (CAR) T masero. Masero eCAR T anokurirwa murabhoritari uye anopiwa murwere nekumukisa. Masero eCAR T anowanda muropa remurwere uye anorwisa maseru egomarara. CAR T-cell Therapy (senge axicabtagene ciloleucel kana tisagenlecleucel) inoshandiswa kurapa hombe B-cell lymphoma iyo isina kupindura kurapwa.

MOTO T-cell kurapa. Rudzi rwekurapa umo masero eT emurwere (rudzi rwemuviri wemasero emuviri) anochinjwa murabhoritari kuitira kuti vasunge masero egomarara vovauraya. Ropa kubva mutsinga iri muruoko rwemurwere inoyerera nepombi kusvika kumuchina weapheresis (usina kuratidzwa), unobvisa masero eropa machena, kusanganisira maT seli, uye wotumira iro rasara rose ropa kumurwere. Zvino, iyo geni yeakagamuchirwa yakakosha inonzi chimeric antigen receptor (CAR) inoiswa mukati meT maseru murabhoritari. Mamirioni emaCAR T maseru anokurirwa murabhoritari uye ndokuzopihwa kumurwere nekumukisa. Masero eCAR T anokwanisa kusunga kune antigen pane masero ekenza uye nekuvauraya.

Ona Zvinodhaka Zvinotenderwa kune Asiri-Hodgkin Lymphoma kuti uwane rumwe ruzivo.

Targeted kurapwa

Targeted therapy mhando yekurapa inoshandisa zvinodhaka kana zvimwe zvinhu kuti zvione uye kurwisa chaiwo maseru ekenza pasina kukuvadza zvakajairika maseru. Monoclonal antibody therapy, proteasome inhibitor therapy, uye kinase inhibitor therapy ndiwo marapirwo akanangwa anoshandiswa kurapa munhu mukuru asiri Hodgkin lymphoma.

Monoclonal antibody therapy ndeye kenza kurapa iyo inoshandisa antibodies inogadzirwa murabhoritari kubva kune imwechete mhando ye immune immune cell. Aya ma antibodies anokwanisa kuona zvinhu pane cancer cancer kana zvakajairika zvinhu zvinogona kubatsira gomarara maseru kukura. Masoja ekudzivirira chirwere anonamira pazvinhu uye anouraya maseru egomarara, anovharira kukura kwawo, kana kuti aachengetedze kubva pakupararira. Inogona kushandiswa yoga kana kutakura zvinodhaka, chepfu, kana zvinhu zvine radioactive zvakanangana nemasero ekenza. Monoclonal antibodies inopihwa nekumisirwa.

Mhando dze monoclonal antibodies dzinosanganisira:

• Rituximab, yaishandiswa kurapa akawanda marudzi asiri eHodgkin lymphoma.

• Obinutuzumab, inoshandiswa kurapa follicular lymphoma.

• Brentuximab vedotin, iyo ine monoclonal antibody inosunga kune protein inonzi CD30 inowanikwa pane mamwe maseru e-lymphoma. Iyo zvakare ine anticancer mushonga uyo unogona kubatsira kuuraya cancer maseru.

• Yttrium Y 90-ibritumomab tiuxetan, muenzaniso weradhiolabeled monoclonal antibody.

Proteasome inhibitor Therapy inodzivirira kuita kweproteasomes mumasero ekenza. MaProteasomes anobvisa mapuroteni asingachadiwe nesero. Kana maproteasomes akavharwa, mapuroteni anovakwa muchitokisi uye anogona kukonzera kuti kenza sero ife. Bortezomib inoshandiswa kudzikisa kuti yakawanda sei immunoglobulin M iri muropa mushure mekurapwa kwekenza kune lymphoplasmacytic lymphoma. Iri zvakare kuongororwa kuti irape yakadzokazve mantle cell lymphoma.

Kinase inhibitor therapy inovhara mamwe mapuroteni, ayo anogona kubatsira kuchengetedza maseru e-lymphoma kubva mukukura uye anogona kuvauraya. Kinase inhibitor Therapies inosanganisira:

• Copanlisib, idelalisib, uye duvelisib, inovhara mapuroteni eP13K uye inogona kubatsira kuchengetedza maseru e-lymphoma kuti asakure. Iyo inoshandiswa kurapa follicular isiri-Hodgkin lymphomas yakadzokazve (kudzoka) kana isina kuzowana zvirinani mushure mekurapwa neanenge mamwe maviri ekurapa.

• Ibrutinib uye acalabrutinib, mhando dzeBruton tyrosine kinase inhibitor therapy. Ivo anoshandiswa kurapa lymphoplasmacytic lymphoma uye mantle cell lymphoma.

Venetoclax inogona zvakare kushandiswa kurapa mantle cell lymphoma. Iyo inovhara kuita kweprotein inonzi B-cell lymphoma-2 (BCL-2) uye inogona kubatsira kuuraya cancer maseru.

Ona Zvinodhaka Zvinotenderwa kune Asiri-Hodgkin Lymphoma kuti uwane rumwe ruzivo.

Plasmapheresis

Kana iro ropa rikava gobvu nemamwe maprotein ekurwisa uye rinokanganisa kutenderera, plasmapheresis inoitwa kubvisa yakawedzera plasma uye antibody protein kubva muropa. Mune maitiro aya, ropa rinobviswa kubva kumurwere uye rinotumirwa kuburikidza nemuchina unoparadzanisa plasma (chikamu chemvura cheropa) kubva kumasero eropa. Plasma yemurwere ine ma antibodies asina kufanira uye haidzorerwe kumurwere. Masero eropa akajairwa anodzoreredzwa muropa pamwe neplasma yakapihwa kana kutsiva plasma. Plasmapheresis haichengetedze masoja matsva kubva pakuumbwa.

Kurinda kumirira

Kurindira kumirira kuri kunyatsoongorora mamiriro emurwere pasina kupa chero kurapwa kusvikira zviratidzo kana zviratidzo zvaonekwa kana kuchinja.

Mishonga inorwisa mabhakitiriya

Mishonga inorwisa mabhakitiriya kurapwa kunoshandisa mishonga kurapa hutachiona uye gomarara rinokonzerwa nehutachiona nezvimwewo zvidiki.

Ona Zvinodhaka Zvinotenderwa kune Asiri-Hodgkin Lymphoma kuti uwane rumwe ruzivo.

Kuvhiya

Kuvhiya kunogona kushandiswa kubvisa iyo lymphoma mune vamwe varwere vane husimbe kana hwehasha husiri-Hodgkin lymphoma.

Mhando yekuvhiya inoshandiswa inoenderana nekuti lymphoma yakaumbwa sei mumuviri:

• Kununurwa kwenzvimbo kwevamwe varwere vane mucosa-inosanganisirwa lymphoid tishu (MALT) lymphoma, PTLD, uye diki ura T-cell lymphoma.

• Splenectomy yevarwere vane marginal zone lymphoma yeiyo spleen.

Varwere vane moyo, mapapu, chiropa, itsvo, kana pancreas kuisirwa kazhinji vanofanirwa kutora mishonga yekudzvinyirira immune system kweupenyu hwavo hwese. Yakareba-refu immunosuppression mushure mekuiswa kwechimwe nhengo inogona kukonzera imwe mhando yeasina-Hodgkin lymphoma inonzi post-transplant lymphoproliferative disorder (PLTD).

Kuvhiya mudiki mudumbu kunowanzo kudikanwa kuti uongorore chirwere checeliac muvanhu vakuru vanokudziridza mhando yeT-cell lymphoma.

Stem cell kuisirwa

Stem cell transplant inzira yekupa yakakwira doses yekemotherapy uye / kana yakazara-muviri irradiation uyezve kutsiva ropa-rinogadzira maseru akaparadzwa nekenza kurapwa. Masero emashizha (masero eropa asina kusimba) anobviswa muropa kana mwongo wemapfupa emurwere (autologous transplant) kana mupi (allogeneic transplant) uye akaomeswa nechando uye akachengetwa. Mushure mekunge chemotherapy uye / kana radiation radiation yapera, maseru akachengetwa anonyungudutswa uye ndokudzoserwa kumurwere kuburikidza nekumukiswa. Aya akadzikiswa maseru emadzinde anokura kuita (uye kudzorera) masero eropa emuviri.

Stem cell kuisirwa. (Nhanho 1): Ropa rinotorwa kubva mutsinga iri muruoko rweanopa. Murwere kana mumwe munhu angave ari mupi. Ropa rinoyerera nemuchina unobvisa masero emadzinde. Ipapo iro ropa rinodzoserwa kune anenge apa kuburikidza netsinga iri mune rumwe ruoko. (Nhanho 2): Murwere anogamuchira chemotherapy kuuraya masero anogadzira ropa. Murwere anogona kupihwa radiation radiation (isina kuratidzwa). (Nhanho 3): Murwere anogamuchira masero emadzinde kuburikidza nekateti yakaiswa mumudziyo weropa muchipfuva.

Mhando nyowani dzekurapa dziri kuyedzwa mumakiriniki ekuedzwa.

Ichi chidimbu chikamu chinotsanangura kurapwa kuri kuongororwa mumakiriniki ekuedzwa. Zvinogona kusataura nezveese marapirwo matsva ari kuongororwa. Ruzivo nezve kiriniki miedzo inowanikwa kubva kuNCI webhusaiti.

Mushonga wekudzivirira

Mushonga wekurapa mushonga wekenza unoshandisa chinhu kana boka rezvinhu kukurudzira immune system kuti iwane iro bundu uye riuraye.

Varwere vangangoda kufunga nezve kutora chikamu mukutora kiriniki.

Kune vamwe varwere, kutora chikamu mumuedzo wekiriniki inogona kunge iri sarudzo yekurapa yakanyanya kunaka. Kliniki miedzo chikamu chekenza tsvagiridzo. Zvemakiriniki miedzo inoitwa kuti uone kana marapirwo matsva egomarara akachengeteka uye achishanda kana zvirinani pane akajairwa kurapwa.

Mazhinji emazuva ano marapirwo akajairwa ekenza akavakirwa pamavambo emakiriniki ekuedzwa. Varwere vanotora chikamu mukuyedzwa kwekiriniki vanogona kuwana kurapwa kwakaringana kana kuve pakati pevekutanga kurapwa kutsva.

Varwere vanotora chikamu mumiedzo yekiriniki zvakare vanobatsira kugadzirisa marapirwo achaitwa kenza mune ramangwana. Kunyangwe kana miedzo yemakiriniki isinga tangire kumarapirwo matsva anoshanda, anowanzo pindura mibvunzo yakakosha uye anobatsira kufambisira mberi kutsvagurudza.

Varwere vanogona kupinda mumakiriniki miedzo vasati, panguva, kana mushure mekutanga kwavo kenza kurapwa.

Mimwe miedzo yekiriniki inosanganisira chete varwere vasati vagamuchira kurapwa. Mimwe miedzo yekuedza kurapwa kwevarwere vane kenza haina kuve nani. Kune mamwezve emakiriniki miedzo inoedza nzira nyowani dzekumisa cancer kubva kudzokororazve (kudzoka) kana kudzikisira mhedzisiro yemakenza kurapwa.

Kuedzwa kwemakiriniki kuri kuitika munzvimbo zhinji dzenyika. Ruzivo nezve kiriniki miedzo inotsigirwa neNCI inogona kuwanikwa paNCI yekiriniki miedzo yekutsvaga peji rewebhu. Kliniki miedzo inotsigirwa nemamwe masangano inogona kuwanikwa pane yeClinicalTrials.gov webhusaiti.

Yekutevera-bvunzo inogona kudikanwa.

Mimwe miedzo yakaitwa kuongorora gomarara kana kutsvaga danho rekenza inogona kudzokororwa. Dzimwe bvunzo dzinodzokororwa kuitira kuti vaone kuti kurapa kuri kushanda sei. Sarudzo nezvekuti uenderere mberi, shandura, kana kumisa kurapwa kunogona kunge kuchibva pamhedzisiro yeiyi bvunzo.

Mimwe bvunzo ichaenderera ichiitwa nguva nenguva mushure mekunge kurapwa kwapera. Mhedzisiro yeiyi bvunzo inogona kuratidza kana mamiriro ako achinja kana kana gomarara radzoka (dzoka). Iyi bvunzo dzimwe nguva inonzi yekuteedzera-bvunzo kana kuongorora-kumusoro.

Kurapa kweIndolent Isiri-Hodgkin Lymphoma

Kuti uwane ruzivo nezve marapirwo akanyorwa pazasi, ona iyo Chikamu Sarudzo Yekutarisa Chikamu.

Kurapa kweiyo indolent nhanho I uye isina kusimba, inokanganisa nhanho yechipiri munhu mukuru asiri Hodgkin lymphoma inogona kusanganisira zvinotevera:

• Radiation kurapa.
• Monoclonal antibody therapy (rituximab) uye / kana chemotherapy.
• Kurinda kumirira.

Kana bundu racho rakanyanya kukura kuti risarapwe nemushonga wemwaranzi, nzira dzekurapa dzevasina kusimba, nhanho yepiri II, III, kana IV mukuru asiri Hodgkin lymphoma ichashandiswa.

Kurapa kweanononoka, asina kujairika nhanho II, III, kana IV mukuru asiri Hodgkin lymphoma inogona kusanganisira zvinotevera:

• Kuchenjerera kumirira varwere vasina zviratidzo kana zviratidzo.

• Monoclonal antibody therapy (rituximab) ine kana isina chemotherapy.

• Kuchengetedza kurapwa ne rituximab.

• Monoclonal antibody kurapa (obinutuzumab).

• PI3K inhibitor therapy (copanlisib, idelalisib, kana duvelisib).

• Lenalidomide uye rituximab.

• Radiolabeled monoclonal antibody kurapa.

• Kuongororwa kwekiriniki yeakakwira-dose chemotherapy ine kana isina yakazara-muviri irradiation kana radiolabeled monoclonal antibody therapy, inoteverwa

• autologous kana allogeneic stem sero rekuisa.

• Kuongororwa kwekiriniki kwechemotherapy kana kuti pasina mushonga wekudzivirira.

• Kuongororwa kwekiriniki yemhando nyowani yemonoclonal antibodies.

• Kuongororwa kwekiriniki kweye radiation kurapwa iyo inosanganisira yepedyo lymph node, yevarwere vane danho III chirwere.

• Kuongororwa kwekiriniki kweyepasi-dose radiation kurapwa, kubvisa zviratidzo uye nekuvandudza hupenyu hwehupenyu.

Mimwe mishonga yekurapa isina-Hodgkin lymphoma inoenderana nerudzi rweiyo isiri Hodgkin lymphoma. Kurapa kunogona kusanganisira zvinotevera:

• Kune follicular lymphoma, kurapwa kunogona kunge kuri mukati mekiriniki kuyedzwa kweye monoclonal antibody therapy, nyowani chemotherapy regimen, kana stem

sero kupinza.

• Ye follicular lymphoma yakadzokazve (kudzoka) kana isina kuita zvirinani mushure mekurapwa, kurapwa kunogona kusanganisira PI3K inhibitor

(copanlisib, idelalisib, kana duvelisib).

• Kune lymphoplasmacytic lymphoma, Bruton tyrosine kinase inhibitor therapy uye / kana plasmapheresis kana proteasome inhibitor therapy (kana zvichidikanwa

kugadzira ropa mutete) inoshandiswa. Mimwe mishonga iyo yakafanana neiya inoshandiswa kune follicular lymphoma inogona kupihwa.

• Kune gastric mucosa-inosanganisirwa lymphoid tishu (MALT) lymphoma, mishonga inorwisa mabhakitiriya yekurapa hutachiona hweHelicobacter pylori inopihwa kutanga.

Kune mamota asingapindure kune inorwisa mabhakitiriya kurapwa, kurapwa kuri radiation radiation, kuvhiya, kana rituximab ine kana isina chemotherapy.

• Nezve extragastric MALT lymphoma yeziso uye yeMediterranean mudumbu lymphoma, mushonga unorwisa mabhakitiriya unoshandiswa kurapa hutachiona.

• Kune splenic marginal zone lymphoma, rituximab ine kana isina chemotherapy uye B-cell receptor therapy inoshandiswa sekutanga kurapwa. Kana bundu risingapindure pakurapwa, splenectomy inogona kuitwa.

Kurapa kweAggressive Non-Hodgkin Lymphoma

Kuti uwane ruzivo nezve marapirwo akanyorwa pazasi, ona iyo Chikamu Sarudzo Yekutarisa Chikamu.

Kurapa kwehasha nhanho ini uye nehasha, inokamurika nhanho II munhu mukuru asiri Hodgkin lymphoma inogona kusanganisira zvinotevera:

• Monoclonal antibody therapy (rituximab) uye mubatanidzwa chemotherapy. Dzimwe nguva kurapwa nemwaranzi kunopihwa gare gare.

• Kuongororwa kwekiriniki yeregimen nyowani yemonoclonal antibody therapy uye musanganiswa chemotherapy.

Kurapa kwechisimba, chisina kujairika nhanho II, III, kana IV mukuru asiri Hodgkin lymphoma inogona kusanganisira zvinotevera:

• Monoclonal antibody therapy (rituximab) pamwe nekubatana chemotherapy.

• Kusanganiswa chemotherapy.

• Kuongororwa kwekiriniki yemonoclonal antibody therapy pamwe neakasanganiswa chemotherapy inoteverwa ne radiation radiation.

Mamwe marapirwo anoenderana nerudzi rwehasha isiri-Hodgkin lymphoma. Kurapa kunogona kusanganisira zvinotevera:

• Kune extranodal NK- / T-cell lymphoma, radiation radiation iyo inogona kupihwa pamberi, panguva, kana mushure memakemikari uye CNS prophylaxis.

• Kune mantle cell lymphoma, monoclonal antibody therapy pamwe nekubatana chemotherapy, inoteverwa ne stem cell transplant. Monoclonal antibody therapy inogona kupihwa mushure meizvozvo senzira yekurapa (kurapwa kunopihwa mushure mekutanga kurapwa kubatsira kuti gomarara rirege kudzoka).

• Kune posttransplantation lymphoproliferative kusagadzikana, kurapwa nemushonga unodzivirira mishonga kunogona kumiswa. Kana izvi zvikasashanda kana zvisingakwanise kuitwa, monoclonal antibody therapy yega kana nekemotherapy inogona kupihwa. Kune kenza isina kupararira, kuvhiya kubvisa cancer kana radiation radiation inogona kushandiswa.

• Kune plasmablastic lymphoma, marapirwo akafanana neaya anoshandiswa kune lymphoblastic lymphoma kana Burkitt lymphoma.

Kuti uwane ruzivo nezve kurapwa kwe lymphoblastic lymphoma, tarisa Kurapa Sarudzo yeLymphoblastic Lymphoma uye neruzivo nezve kurapwa kweBurkitt lymphoma, ona Kurapa Sarudzo dzeBurkitt Lymphoma.

Kurapa kweLymphoblastic Lymphoma

Kuti uwane ruzivo nezve marapirwo akanyorwa pazasi, ona iyo Chikamu Sarudzo Yekutarisa Chikamu.

Kurapa kwevanhu vakuru lymphoblastic lymphoma kunogona kusanganisira zvinotevera:

• Kusanganiswa chemotherapy uye CNS prophylaxis. Dzimwe nguva kurapwa nemwaranzi kunopihwa kudzikisa bundu rakakura.

• Targeted Therapy ine monoclonal antibody yega (rituximab) kana inosanganiswa ne kinase inhibitor therapy (ibrutinib).

• Kuongororwa kwekiriniki ye stem cell transplant mushure mekutanga kurapwa.

Kurapa kweBurkitt Lymphoma

Kuti uwane ruzivo nezve marapirwo akanyorwa pazasi, ona iyo Chikamu Sarudzo Yekutarisa Chikamu.

Kurapa kwevakuru Burkitt lymphoma kunogona kusanganisira zvinotevera:

• Kusanganiswa chemotherapy pamwe kana pasina monoclonal antibody therapy.

• CNS kudzivirira.

Kurapa kweRecrerent Non-Hodgkin Lymphoma

Kuti uwane ruzivo nezve marapirwo akanyorwa pazasi, ona iyo Chikamu Sarudzo Yekutarisa Chikamu.

Kurapa kweanorega, anowanzoitika munhu mukuru asiri Hodgkin lymphoma anogona kusanganisira zvinotevera:

• Chemotherapy neimwe kana zvimwe zvinodhaka.

• Monoclonal antibody therapy (rituximab kana obinutuzumab).

• Lenalidomide.

• Radiolabeled monoclonal antibody kurapa.

• Radiation kurapa senge palliative kurapa kubvisa zviratidzo uye nekuvandudza hupenyu hwehupenyu.

• Kuongororwa kwekiriniki kweiyo autologous kana allogeneic stem sero kuisirwa.

Kurapa kwehasha, munhu mukuru anowanzoitika asiri Hodgkin lymphoma inogona kusanganisira zvinotevera:

• Chemotherapy ine kana isina stem cell yekuisa.

• Monoclonal antibody therapy ine kana isina kusangana chemotherapy inoteverwa ne autologous stem cell yekuisa.

• Radiation kurapa senge palliative kurapa kubvisa zviratidzo uye nekuvandudza hupenyu hwehupenyu.

• Radiolabeled monoclonal antibody kurapa.

• MOTO T-cell kurapa.

• Kune mantle cell lymphoma, kurapwa kunogona kusanganisira zvinotevera:

• Bruton tyrosine kinase inhibitor kurapa.

• Lenalidomide.

• Kuongororwa kwekiriniki yelenalidomide ne monoclonal antibody therapy.

• Kuongororwa kwekiriniki kuenzanisa lenalidomide neimwe kurapwa.

• Kuongororwa kwekiriniki yeproteasome inhibitor therapy (bortezomib).

• Kuongororwa kwekiriniki kweiyo autologous kana allogeneic stem sero kuisirwa.

Kurapa kweiyo indolent lymphoma inodzoka seine hukasha lymphoma kunoenderana nerudzi rweiyo isiri-Hodgkin lymphoma uye inogona kusanganisira radiation radiation senge yekurapa kurapa kubvisa zviratidzo uye nekuvandudza hupenyu hwehupenyu. Kurapa kwehasha lymphoma iyo inodzoka seyakaremara lymphoma inogona kusanganisira chemotherapy.

Kurapa kweiyo isiri-Hodgkin Lymphoma Panguva Yepamuviri

Muchikamu chino

• Indolent Isiri-Hodgkin Lymphoma Panguva Yepamuviri

• Hasha Isina-Hodgkin Lymphoma Panguva Yepamuviri

Kuti uwane ruzivo nezve marapirwo akanyorwa pazasi, ona iyo Chikamu Sarudzo Yekutarisa Chikamu.

Indolent Isiri-Hodgkin Lymphoma Panguva Yepamuviri

Vakadzi vane husimbe (husina kukura-husina kukura) husiri Hodgkin lymphoma panguva yekuzvitakura vanogona kurapwa nekurindira vakamirira kusvikira vasununguka. (Ona iyo Kurapa Sarudzo dzeIndolent Isiri-Hodgkin Lymphoma chikamu kuti uwane rumwe ruzivo.)

Hasha Isina-Hodgkin Lymphoma Panguva Yepamuviri

Kurapa kwehasha isiri-Hodgkin lymphoma panguva yekuzvitakura kunogona kusanganisira zvinotevera:

• Kurapa kunopihwa ipapo ipapo zvichibva parudzi rweiyo isiri Hodgkin lymphoma kuwedzera mukana waamai wekupona. Kurapa kunogona kusanganisira kusanganisa chemotherapy uye rituximab.

• Kuzvarwa kwekutanga kwemwana kunoteverwa nekurapwa kunoenderana nerudzi rweiyo isiri Hodgkin lymphoma.

• Kana mune yekutanga trimester yepamuviri, vezvekurapa oncologists vanogona kuraira kupedza nhumbu kuitira kuti kurapwa kutange. Kurapa kunoenderana nerudzi rweusiri-Hodgkin lymphoma.

Kuti udzidze Zvakawanda Nezvevakuru Vasina-Hodgkin Lymphoma

Kuti uwane rumwe ruzivo kubva kuNational Cancer Institute nezve munhu mukuru asiri Hodgkin lymphoma, ona zvinotevera:

• Asiri-Hodgkin Lymphoma Peji Rekutanga

• Zvinodhaka Zvinotenderwa kune Asiri-Hodgkin Lymphoma

• Targeted Cancer Therapies

• Immunotherapy Kurapa Cancer

Kuti uwane ruzivo rwekenza uye zvimwe zviwanikwa kubva kuNational Cancer Institute, ona zvinotevera:

• Nezve Kenza

• Stage

• Chemotherapy uye Iwe: Tsigiro Yevanhu Vane Kenza

• Radiation Therapy uye Iwe: Rutsigiro rweVanhu Vane Kenza

• Kurarama neCancer

• Mibvunzo Yekubvunza Wako Chiremba nezveCancer

• Kune Vakapona uye Vanotarisira