Types/leukemia/patient/adult-all-treatment-pdq

Vakuru Acute Lymphoblastic Leukemia Kurapa (?) - Patient Shanduro

General Ruzivo nezveVakuru Acute Lymphoblastic Leukemia

PFUNGWA DZINOKOSHA

• Adult acute lymphoblastic leukemia (ZVA) rudzi rwegomarara umo mwongo wemapfupa unoita ma lymphocyte akawandisa (rudzi rwechena rweropa).

• Leukemia inogona kukanganisa masero matsvuku eropa, machena masero eropa, uye maplatelet.

• Yapfuura chemotherapy uye kuratidzwa kune radiation kunogona kuwedzera njodzi yekuvandudza ZVESE.

• Zviratidzo nezviratidzo zvevakuru ZVESE zvinosanganisira kupisa muviri, kunzwa kuneta, uye kupwanya kuri nyore kana kubuda ropa.

• Kuyedza kunoongorora ropa nemwongo wemapfupa kunoshandiswa kuona (kutsvaga) uye kuongorora vakuru VESE.

• Zvimwe zvinhu zvinokanganisa kufungidzira (mukana wekupora) uye sarudzo dzekurapa.

Adult acute lymphoblastic leukemia (ZVA) rudzi rwegomarara umo mwongo wemapfupa unoita ma lymphocyte akawandisa (rudzi rwechena rweropa).

Mukuru acute lymphoblastic leukemia (ALL; inonziwo acute lymphocytic leukemia) igomarara reropa nemapfupa. Rudzi urwu rwegomarara kazhinji runokurumidza kukura kana rukasarapwa.

Anatomy yebhonzo. Bhonzo rinoumbwa necompact bone, spongy bone, uye mwongo wefupa. Compact bone rinoumba chikamu chekunze chepfupa. Spongy bone rinowanikwa zvakanyanya kumagumo emabhonzo uye rine mutsvuku. Bhonzo remapfupa rinowanikwa pakati pemapfupa mazhinji uye rine tsinga zhinji dzeropa. Kune mhando mbiri dzemongo wemapfupa: tsvuku uye yero. Mutsvuku mutsvuku une masero eropa anogona kuve masero matsvuku eropa, machena masero eropa, kana maplatelet. Yero mwongo inogadzirwa kazhinji yemafuta.

Leukemia inogona kukanganisa masero matsvuku eropa, machena masero eropa, uye maplatelet.

Kazhinji, mwongo wemapfupa unoita maseru eropa (maseru asina kukura) anova masero eropa akakura nekufamba kwenguva. Sero reropa rinogona kuva myeloid stem cell kana lymphoid stem cell.

Iyo myeloid stem sero inova imwe yemhando nhatu dzemasero eropa akura:

• Masero matsvuku eropa anotakura okisijeni nezvimwe zvinhu kumatishu ese emuviri.

• Maplatelet ayo anogadzira ropa kuwacha kubuda ropa.

• Granulocytes (machena masero eropa) ayo anorwisa hutachiona nezvirwere.

A lymphoid stem cell inova lymphoblast cell uyezve imwe yemhando nhatu dze lymphocyte (machena masero eropa):

• B ma lymphocyte anogadzira masoja ekudzivirira chirwere.

• T lymphocyte dzinobatsira B lymphocyte kugadzira masoja ekudzivirira anobatsira kurwisa hutachiona.

• Maseru anouraya chaiwo anorwisa cancer maseru uye hutachiona.

Ropa masero kukura. Sero reropa rinopinda nematanho akati wandei kuti riite tsvuku reropa, platelet, kana chena reropa.

Mune ZVESE, akawanda maseru maseru anova ma lymphoblasts, B lymphocyte, kana T lymphocyte. Aya maseru anonziwo maseru eukemia. Aya maseru eleukemia haakwanise kurwisa hutachiona zvakanyanya. Zvakare, sezvo huwandu hwemaseru eukemia hunowedzera muropa nemongo wemapfupa, pane nzvimbo shoma yemasero eropa ane hutano, masero matsvuku eropa, uye maplatelet. Izvi zvinogona kukonzera hutachiona, kupererwa neropa, uye nyore kubuda ropa. Gomarara iri rinogonawo kupararira kusvika panhanho yepakati (huropi uye musana).

Iyi pfupiso ndeye munhu mukuru acute lymphoblastic leukemia. Ona inotevera pfupiso yePDPQ yeruzivo nezve mamwe marudzi eleukemia:

• Zvepwere Acute Lymphoblastic Leukemia Kurapa.

• Vakuru Acute Myeloid Leukemia Kurapa.

• Zvepwere Acute Myeloid Leukemia / Imwe Myeloid Malignancies Kurapa.

• Chisingaperi Lymphocytic Leukemia Kurapa.

• Chisingaperi Myelogenous Leukemia Kurapa.

• Bvudzi Cell Leukemia Kurapa.

Yapfuura chemotherapy uye kuratidzwa kune radiation kunogona kuwedzera njodzi yekuvandudza ZVESE.

Chero chipi zvacho chinowedzera njodzi yako yekuwana chirwere chinonzi njodzi chinhu. Kuva nenjodzi hazvireve kuti uchawana gomarara; kusava nenjodzi hazvireve kuti hauzobatwe negomarara. Taura nachiremba wako kana iwe uchifunga kuti ungave uri panjodzi. Zvimwe zvinogona kuisa njodzi kune VESE zvinosanganisira zvinotevera:

• Kuva murume.

• Kuva chena.

• Kuva mukuru kudarika makumi manomwe.

• Kurapa kwekare nekemotherapy kana radiation radiation.

• Kuoneswa pachena kumazinga akanyanya emwaranzi mune zvakatipoteredza (senge radiation yenyukireya).

• Kuve nehumwe hutachiona kusagadzikana, senge Down syndrome.

Zviratidzo nezviratidzo zvevakuru ZVESE zvinosanganisira kupisa muviri, kunzwa kuneta, uye kupwanya kuri nyore kana kubuda ropa.

Zviratidzo zvekutanga nezviratidzo zveZESE zvinogona kunge zvakaita furuwenza kana zvimwe zvirwere zvakajairika. Tarisa nachiremba wako kana iwe uine chero chinotevera:

• Kuneta kana kunzwa kuneta.

• Fivha kana husiku hweziya.

• Kupwanya kuri nyore kana kubuda ropa.

• Petechiae (yakati sandara, inonongedza nzvimbo pasi peganda, inokonzerwa nekubuda ropa).

• Kufema kwekufema.

• Kurera huremu kana kurasikirwa nechido.

• Marwadzo mumapfupa kana mudumbu.

• Marwadzo kana kunzwa kwekuzara pazasi pembabvu.

• Mapundu asingarwadzire mumutsipa, pasi pechipfuva, mudumbu, kana kugomera.

• Kuva nezvirwere zvakawanda.

Izvi nezvimwe zviratidzo uye zviratidzo zvinogona kukonzerwa nevakuru acute lymphoblastic leukemia kana nemamwe mamiriro.

Kuyedza kunoongorora ropa nemwongo wemapfupa kunoshandiswa kuona (kutsvaga) uye kuongorora vakuru VESE.

Iyi inotevera bvunzo uye maitiro anogona kushandiswa:

• Kuongorora kwepanyama uye nhoroondo: Kuongororwa kwemuviri kutarisa zviratidzo zvehutano, kusanganisira kuongorora zviratidzo zvehosha, senge hutachiona kana chero chinhu chinoratidzika sechisina kujairika. Nhoroondo yemaitiro ehutano hwemurwere uye kurwara kwakapfuura uye kurapwa kuchatorwawo.

• Yakazara huwandu hweropa (CBC) nemusiyano: Maitiro umo muyenzaniso weropa unodhonzwa nekuongororwa zvinotevera:

• Huwandu hwemasero matsvuku eropa nemaplatelet.

• Nhamba uye mhando yemasero machena eropa.

• Huwandu hwehemoglobin (protein inotakura oxygen) mumasero matsvuku eropa.

• Chikamu chemuenzaniso weropa chakaumbwa nemasero matsvuku eropa.

Yakazara kuverenga ropa (CBC). Ropa rinounganidzwa nekupinza tsono mutsinga uye richiita kuti ropa riyerere muhubhu. Muenzaniso weropa unotumirwa murabhoritari uye masero matsvuku eropa, masero machena eropa, uye maplatelet anoverengwa. Iyo CBC inoshandiswa kuyedza, kuongorora, uye kuongorora akawanda mamiriro akasiyana.

• Ropa kemesitiri zvidzidzo: Maitiro umo muyedzo weropa unoongororwa kuyera huwandu hwezvimwe zvinhu zvakaburitswa muropa nenhengo uye nyama munyama. Chinhu chisina kujairika (chakakwirira kana chakaderera pane zvakajairwa) chiyero chechinhu chinogona kunge chiri chiratidzo chechirwere.

• Peripheral ropa smear: Maitiro umo muyenzaniso weropa unotariswa nekufema masero, nhamba uye mhando dzemasero machena eropa, huwandu hwemaplatelet, uye shanduko muchimiro chemasero eropa.

• Bone marrow aspiration uye biopsy: Kubviswa kwemongo wefupa, ropa, uye chidimbu chefupa nekuisa tsono isina mhango muhudyu kana pfupa rechipfuva. Nyanzvi yezvirwere anoona pfupa, ropa, uye pfupa pasi pe microscope kutsvaga masero asina kujairika.

Bone marora chishuwo uye biopsy. Mushure mekunge nzvimbo diki yeganda yave nechiveve, tsono yemongo wemapfupa inoiswa mupfupa rehudyu remurwere. Samples reropa, bhonzo, uye mwongo wemapfupa zvinobviswa kuti zviongororwe pasi pe microscope.

Iyi miedzo inotevera inogona kuitwa pane masampula eropa kana mapfupa emwongo anobviswa.

• Kuongorora kweCytogenetic: Kuongororwa kwerabhoritari umo ma chromosomes emaseru mune muyenzaniso weropa kana mongo wemapfupa anoverengwa uye kuongororwa chero shanduko, sekutyorwa, kushaikwa, kurongedzwa patsva, kana mamwe ma chromosomes. Shanduko mune mamwe ma chromosomes inogona kunge iri chiratidzo checancer. Semuenzaniso, muPhiladelphia chromosome-yakanaka ZVESE, chikamu cheimwe chromosome inoshandura nzvimbo ine chikamu cheimwe chromosome. Iyi inonzi "chromosome yePhiladelphia." Kuongorora kweCytogenetic kunoshandiswa kubatsira kuongorora cancer, kuronga kurapwa, kana kuona kuti kurapa kuri kushanda sei.

Philadelphia chromosome. Chidimbu chechromosome 9 uye chidimbu chekromosome 22 chinoputsa uye nzvimbo dzekutengesa. Iyo BCR-ABL gene inoumbwa pane chromosome 22 apo chidimbu che chromosome 9 chinonamira. Iyo yakachinja chromosome 22 inonzi iyo Philadelphia chromosome.

• Immunophenotyping: Kuongororwa kwerabhoritari inoshandisa masoja ekudzivirira kenza maseru zvichibva pamhando dzemaantigen kana mamaki ari pamusoro pemasero. Iyi bvunzo inoshandiswa kubatsira kuongorora chaiwo marudzi eleukemia. Semuenzaniso, cytochemistry yekudzidza inogona kuyedza masero mune imwe sosi yetishu uchishandisa makemikari (madhayi) kutsvaga dzimwe shanduko mune iyi sampuro. Kemikari inogona kukonzera shanduko yemuvara mune imwe mhando yeeleukemia cell asi kwete mune imwe mhando yeleukemia cell.

Zvimwe zvinhu zvinokanganisa kufungidzira (mukana wekupora) uye sarudzo dzekurapa.

Kufungidzira (mukana wekupora) uye sarudzo dzekurapa dzinoenderana nezvinotevera:

• Zera remurwere.

• Kunyangwe kenza yapararira kuuropi kana musana.

• Kunyangwe paine zvimwe shanduko mumajene, kusanganisira iyo Philadelphia chromosome.

• Kunyangwe gomarara rakamborapwa kare kana kuti radzokazve (dzoka).

Matanho eVakuru Acute Lymphoblastic Leukemia

PFUNGWA DZINOKOSHA

• Kana munhu ZVIZVO akange aonekwa, kuongororwa kunoitwa kuti uone kana gomarara rapararira kunzvimbo yepakati yetsinga (huropi uye musana) kana kune dzimwe nhengo dzemuviri.

• Iko hakuna standard standard staging system yevakuru VESE.

Kana munhu ZVIZVO akange aonekwa, kuongororwa kunoitwa kuti uone kana gomarara rapararira kunzvimbo yepakati yetsinga (huropi uye musana) kana kune dzimwe nhengo dzemuviri.

Iko kukura kana kupararira kwegomarara kunowanzo rondedzerwa sematanho. Izvo zvakakosha kuti uzive kana leukemia yapararira kunze kweropa nemongo wemapfupa kuitira kuronga kurapwa. Iyi inotevera bvunzo uye maitiro anogona kushandiswa kuona kana leukemia yapararira:

• Chest x-ray: X-ray yenhengo nemapfupa mukati mechipfuva. X-ray imhando yesimba remagetsi rinogona kupfuura nemuviri uye kupinda mufirimu, richiita mufananidzo wenzvimbo dziri mukati memuviri.

• Lumbar puncture: Maitiro anoshandiswa kuunganidza sampu yecebrospinal fluid (CSF) kubva pamutsipa wepelinha. Izvi zvinoitwa nekuisa tsono pakati pemabhonzo maviri mumuzongoza nekupinda muCSF yakakomberedza musana uye kubvisa sampu yemvura. Muenzaniso weCSF unotariswa pasi pe microscope yezviratidzo zvekuti masero erukemia apararira kuuropi uye musana. Maitiro aya anonzi zvakare LP kana musana tap.

Lumbar kubaya. Murwere akarara panzvimbo yakamonana patafura. Mushure mekunge diki nzvimbo kumucheto kumashure yave chiveve, tsono yemusana (tsono refu, nhete) inoiswa muchikamu chezasi chepamuviri mbichana kubvisa cerebrospinal fluid (CSF, inoratidzwa mublue). Mvura yacho inogona kutumirwa kurabhoritari kunoongororwa.

• CT scan (CAT scan): Maitiro anoita akateedzana emifananidzo yakajeka yedumbu, inotorwa kubva kumakona akasiyana. Mifananidzo yacho inogadzirwa nekombuta yakabatana neiyo x-ray muchina. Dhayi inogona kuiswa jekiseni kana kumedzwa kubatsira nhengo kana zvinyama kuratidza zvakajeka. Iyi nzira inonziwo computed tomography, computerized tomography, kana komputa axial tomography.

• MRI (magnetic resonance imaging): Maitiro anoshandisa magineti, masaisai eredhiyo, uye komputa kugadzira yakateedzana mifananidzo yakajeka yenzvimbo dziri mukati memuviri. Iyi nzira inonziwo nyukireya magnetic resonance imaging (NMRI).

Iko hakuna standard standard staging system yevakuru VESE.

Chirwere chinotsanangurwa sechisina kurapwa, mukuregererwa, kana kudzoka.

Asina kurapwa vakuru

ZVESE zvichangobva kuongororwa uye hazvina kurapwa kunze kwekubvisa zviratidzo nezviratidzo zvakaita sefivha, kubuda ropa, kana kurwadziwa.

• Iyo yakazara yakazara kuverenga haina kujairika.

• Zvinopfuura zvikamu zvishanu kubva muzana zvemasero ari mumongo wemapfupa zvinoputika (masero eleukemia).

• Pane zviratidzo nezviratidzo zveleukemia.

Vakuru Vese mukuregerera

Izvo zvese zvakarapwa.

• Kuwanda kweropa kwakazara kunoitika.

• 5% kana mashoma emasero ari mumongo wemapfupa anoputika (leukemia maseru).

• Iko hakuna zviratidzo kana zviratidzo zveleukemia kunze kwepfupa remongo.

Kudzokorora Kwevanhu Vakuru Acute Lymphoblastic Leukemia

Anowanzoitika munhu mukuru acute lymphoblastic leukemia (ZVA) kenza yakadzokazve (kudzoka) mushure mekuenda mukuregererwa. ZVESE zvinogona kudzoka muropa, mwongo wemabhonzo, kana zvimwe zvikamu zvemuviri.

Kurapa Sarudzo Kuongorora

PFUNGWA DZINOKOSHA

• Kune akasiyana marudzi ekurapa kwevarwere vane vakuru VESE.
• Kurapa kwevakuru munhu wese kazhinji kune zvikamu zviviri.
• Mhando ina dzekurapa kwakajairika dzinoshandiswa:

• Chemotherapy

• Radiation kurapa

• Chemotherapy ne stem cell yekuisa

• Targeted kurapwa

• Mhando nyowani dzekurapa dziri kuyedzwa mumakiriniki ekuedzwa.

• Immunotherapy

• Varwere vangangoda kufunga nezve kutora chikamu mukutora kiriniki.

• Varwere vanogona kupinda mumakiriniki miedzo vasati, panguva, kana mushure mekutanga kwavo kenza kurapwa.

• Kurapa kwevakuru acute lymphoblastic leukemia kunogona kukonzera mhedzisiro.

• Yekutevera-bvunzo inogona kudikanwa.

Kune akasiyana marudzi ekurapa kwevarwere vane vakuru VESE.

Mhando dzakasiyana dzekurapa dzinowanikwa kune varwere vane vakuru acute lymphoblastic leukemia (ALL). Mamwe marapirwo akajairwa (iko kurapwa kwazvino kwashandiswa), uye kumwe kuedzwa mumakiriniki ekuedzwa A kurapwa kiriniki kuyedzwa chidzidzo chekutsvaga chakaitirwa kubatsira kuvandudza marapirwo azvino kana kuwana ruzivo marapirwo matsva evarwere vane gomarara. Kana kiriniki miedzo ikaratidza kuti kurapwa kutsva kuri nani pane kwese kurapwa, kurapwa kutsva kunogona kuve kwakajairwa kurapwa. Varwere vangangoda kufunga nezve kutora chikamu mukutora kiriniki. Mimwe miedzo yekiriniki yakavhurwa chete kune varwere vasina kutanga kurapwa.

Kurapa kwevakuru munhu wese kazhinji kune zvikamu zviviri.

Kurapa kwevakuru ZVESE kunoitwa muzvikamu:

• Kuregererwa induction Therapy: Ichi chikamu chekutanga chekurapa. Chinangwa ndechekuuraya masero eleukemia muropa nemongo wemapfupa. Izvi zvinoisa leukemia mukuregererwa.

• Post-remission therapy: Ichi chikamu chechipiri chekurapa. Inotanga kana leukemia yava mukuregererwa. Chinangwa chekurapa-kuregererwa kurapa kuuraya chero maseru eleukemia akasara anogona kunge asiri kushanda asi anogona kutanga kudzoka uye kukonzera kudzokazve. Ichi chikamu chinonzi zvakare kuregererwa kuenderera mberi kurapwa.

Kurapa kunonzi central nervous system (CNS) prophylaxis therapy inowanzo kupihwa panguva yega yega chikamu chekurapa. Nekuti zviyero zvakajairika zvemakemikari ekurapa anogona kutadza kusvika kumasero eleukemia muCNS (huropi uye musana), maseru eleukemia anokwanisa kuhwanda muCNS. Systemic chemotherapy yakapihwa muyero yakakwira, intrathecal chemotherapy, uye radiation radiation kuuropi inokwanisa kusvika masero eleukemia muCNS. Aya marapirwo anopiwa kuuraya masero eleukemia uye kudzikisira mukana wekuti leukemia idzokere (kudzoka).

Mhando ina dzekurapa kwakajairika dzinoshandiswa:

Chemotherapy

Chemotherapy mushonga wekenza unoshandisa mishonga kumisa kukura kwemasero ekenza, kungave nekuuraya maseru kana nekuamisa iwo kubva pakupatsanuka. Kana chemotherapy ikatorwa nemuromo kana kujowa mutsinga kana mhasuru, mishonga inopinda muropa uye inogona kusvika masero emukenza mumuviri wese (systemic chemotherapy). Kana chemotherapy ikaiswa yakanangana necerebrospinal fluid (intrathecal chemotherapy), nhengo, kana dumbu remuviri senge dumbu, mishonga inonyanya kukanganisa maseru ekenza munzvimbo idzodzo (chemotherapy yedunhu). Kusanganiswa chemotherapy kurapwa kunoshandisa anopfuura imwe anticancer mushonga. Nzira iyo chemotherapy inopihwa inoenderana nerudzi uye nhanho yekenza iri kurapwa.

Intrathecal chemotherapy inogona kushandiswa kurapa munhu mukuru ZVESE izvo zvakapararira, kana zvinogona kupararira, kuuropi uye musana. Kana ikashandiswa kudzikisa mukana weleukemia maseru anopararira kusvika kuuropi uye musana, inonzi CNS prophylaxis.

Intrathecal chemotherapy. Anticancer zvinodhaka zvinopinda mukati meiyo intrathecal nzvimbo, inova iyo nzvimbo inobata iyo cerebrospinal fluid (CSF, inoratidzwa mublue). Pane nzira mbiri dzakasiyana dzekuita izvi. Imwe nzira, inoratidzwa muchikamu chepamusoro chemufananidzo, kuisa majekiseni mumugodhi weOmaya (mudziyo wakaita sedome wakaiswa pasi peganda panguva yekuvhiyiwa; inobata mishonga painenge ichiyerera nepombi diki ichienda muuropi ). Imwe nzira, inoratidzwa muchikamu chepazasi chemufananidzo, kupinza mishonga yakananga muCSF muchikamu chepazasi chechipenga chemusana, mushure mekunge nzvimbo diki kumusana wezasi yave nechiveve.

Ona Zvinodhaka Zvinotenderwa kune Acute Lymphoblastic Leukemia kuti uwane rumwe ruzivo.

Radiation kurapa

Radiation kurapa kurapwa kenza iyo inoshandisa yakakwira-simba x-rays kana mamwe marudzi e radiation kuuraya cancer maseru kana kuachengeta iwo kuti asakure. Kune mhando mbiri dze radiation radiation:

• External radiation therapy inoshandisa muchina uri kunze kwemuviri kutumira radiation kune kenza.

• Yemukati radiation kurapwa kunoshandisa radioactive chinhu chakavharirwa mune tsono, mhodzi, waya, kana makateti anoiswa akananga mukati kana padyo nekenza.

Nzira iyo marapi ekurapa anopiwa anoenderana nerudzi rwegomarara. External radiation therapy inogona kushandiswa kurapa munhu mukuru ZVESE zvakapararira, kana zvinogona kupararira, kuuropi uye musana. Kana ichishandiswa nenzira iyi, inonzi central nervous system (CNS) nzvimbo tsvene yekurapa kana CNS prophylaxis. Kunze kweradiotherapy kurapwa kunogona zvakare kushandiswa senge palliative kurapa kubvisa zviratidzo uye nekuvandudza hupenyu hwehupenyu.

Chemotherapy ne stem cell yekuisa

Chemotherapy inopihwa kuuraya cancer maseru. Masero ane hutano, kusanganisira masero anogadzira ropa, anoparadzwa nekenza kurapwa. Stem cell transplant kurapwa kwekutsiva maseru anogadzira ropa. Masero emashizha (masero eropa asina kusimba) anobviswa muropa kana mwongo wemapfupa emurwere kana mupi uye anoomeswa nechando. Mushure mekunge murwere apedza chemotherapy, maseru akachengetwa anonyungudutswa uye ndokudzoserwa kumurwere kuburikidza nekumukiswa. Aya akadzikiswa maseru emadzinde anokura kuita (uye kudzoreredza) masero eropa emuviri.

Ona Zvinodhaka Zvinotenderwa kune Acute Lymphoblastic Leukemia kuti uwane rumwe ruzivo.

Stem cell kuisirwa. (Nhanho 1): Ropa rinotorwa kubva mutsinga iri muruoko rweanopa. Murwere kana mumwe munhu angave ari mupi. Ropa rinoyerera nemuchina unobvisa masero emadzinde. Ipapo iro ropa rinodzoserwa kune anenge apa kuburikidza netsinga iri mune rumwe ruoko. (Nhanho 2): Murwere anogamuchira chemotherapy kuuraya masero anogadzira ropa. Murwere anogona kupihwa radiation radiation (isina kuratidzwa). (Nhanho 3): Murwere anogamuchira masero emadzinde kuburikidza nekateti yakaiswa mumudziyo weropa muchipfuva.

Targeted kurapwa

Targeted therapy mhando yekurapa inoshandisa zvinodhaka kana zvimwe zvinhu kuti zvione uye kurwisa chaiwo maseru ekenza pasina kukuvadza zvakajairika maseru. Monoclonal antibody therapy uye tyrosine kinase inhibitor kurapa ndiwo marudzi eanotarisirwa kurapwa anoshandiswa kurapa vakuru VESE.

Monoclonal antibody therapy ndeye kenza kurapa iyo inoshandisa masoja akagadzirwa murabhoritari, kubva kune imwechete mhando yemasoja ekudzivirira maseru. Aya ma antibodies anokwanisa kuona zvinhu pane cancer cancer kana zvakajairika zvinhu zvinogona kubatsira gomarara maseru kukura. Masoja ekudzivirira chirwere anonamira pazvinhu uye anouraya maseru egomarara, anovharira kukura kwawo, kana kuachengeta kuti asapararire. Monoclonal antibodies inopihwa nekumisirwa. Inogona kushandiswa yoga kana kutakura zvinodhaka, chepfu, kana zvinhu zvine radioactive zvakanangana nemasero ekenza. Blinatumomab uye inotuzumab ozogamicin ndiwo monoclonal antibodies anoshandiswa ne stem cell yekuisa kurapa munhu mukuru ZVESE.

Tyrosine kinase inhibitor therapy inovhara iyo enzyme, tyrosine kinase, iyo inokonzeresa masero emadzinde kukura kuva mamwe machena masero eropa (kuputika) kupfuura izvo zvinodiwa nemuviri. Imatinib mesylate (Gleevec), dasatinib, uye nilotinib ndeye tyrosine kinase inhibitors anoshandiswa kurapa munhu mukuru ZVESE.

Ona Zvinodhaka Zvinotenderwa kune Acute Lymphoblastic Leukemia kuti uwane rumwe ruzivo.

Mhando nyowani dzekurapa dziri kuyedzwa mumakiriniki ekuedzwa.

Ichi chidimbu chikamu chinotsanangura kurapwa kuri kuongororwa mumakiriniki ekuedzwa. Zvinogona kusataura nezveese marapirwo matsva ari kuongororwa. Ruzivo nezve kiriniki miedzo inowanikwa kubva kuNCI webhusaiti.

Immunotherapy

Immunotherapy kurapwa kunoshandisa immune system yemurwere kurwisa gomarara. Zvinhu zvinogadzirwa nemuviri kana kugadzirwa murabhoritari zvinoshandiswa kusimudzira, kunongedza, kana kudzorera kudzivirira kwemuviri kurwisa kenza. Rudzi rwekurapa kenza urwu rwunonziwo biotherapy kana biologic therapy.

CAR T-cell kurapa rudzi rwe immunotherapy iyo inoshandura yemurwere T masero (rudzi rwe immune immune cell) saka ivo vanozorwisa mamwe mapuroteni ari pamusoro pecancer maseru. T maseru anotorwa kubva kumurwere uye akakosha maakagamuchirwa anowedzerwa kumusoro kwawo murabhoritari. Masero akachinjwa anonzi chimeric antigen receptor (CAR) T masero. Masero eCAR T anokurirwa murabhoritari uye anopiwa murwere nekumukisa. Masero eCAR T anowanda muropa remurwere uye anorwisa maseru egomarara. CAR T-cell kurapa kuri kuongororwa mukurapa kwevakuru ZVESE izvo zvadzokazve (dzoka).

MOTO T-cell kurapa. Rudzi rwekurapa umo masero eT emurwere (rudzi rwemuviri wemasero emuviri) anochinjwa murabhoritari kuitira kuti vasunge masero egomarara vovauraya. Ropa kubva mutsinga iri muruoko rwemurwere inoyerera nepombi kusvika kumuchina weapheresis (usina kuratidzwa), unobvisa masero eropa machena, kusanganisira maT seli, uye wotumira iro rasara rose ropa kumurwere. Zvino, iyo geni yeakagamuchirwa yakakosha inonzi chimeric antigen receptor (CAR) inoiswa mukati meT maseru murabhoritari. Mamirioni emaCAR T maseru anokurirwa murabhoritari uye ndokuzopihwa kumurwere nekumukisa. Masero eCAR T anokwanisa kusunga kune antigen pane masero ekenza uye nekuvauraya.

Varwere vangangoda kufunga nezve kutora chikamu mukutora kiriniki.

Kune vamwe varwere, kutora chikamu mumuedzo wekiriniki inogona kunge iri sarudzo yekurapa yakanyanya kunaka. Kliniki miedzo chikamu chekenza tsvagiridzo. Zvemakiriniki miedzo inoitwa kuti uone kana marapirwo matsva egomarara akachengeteka uye achishanda kana zvirinani pane akajairwa kurapwa.

Mazhinji emazuva ano marapirwo akajairwa ekenza akavakirwa pamavambo emakiriniki ekuedzwa. Varwere vanotora chikamu mukuyedzwa kwekiriniki vanogona kuwana kurapwa kwakaringana kana kuve pakati pevekutanga kurapwa kutsva.

Varwere vanotora chikamu mumiedzo yekiriniki zvakare vanobatsira kugadzirisa marapirwo achaitwa kenza mune ramangwana. Kunyangwe kana miedzo yemakiriniki isinga tangire kumarapirwo matsva anoshanda, anowanzo pindura mibvunzo yakakosha uye anobatsira kufambisira mberi kutsvagurudza.

Varwere vanogona kupinda mumakiriniki miedzo vasati, panguva, kana mushure mekutanga kwavo kenza kurapwa.

Mimwe miedzo yekiriniki inosanganisira chete varwere vasati vagamuchira kurapwa. Mimwe miedzo yekuedza kurapwa kwevarwere vane kenza haina kuve nani. Kune mamwezve emakiriniki miedzo inoedza nzira nyowani dzekumisa cancer kubva kudzokororazve (kudzoka) kana kudzikisira mhedzisiro yemakenza kurapwa.

Kuedzwa kwemakiriniki kuri kuitika munzvimbo zhinji dzenyika. Ruzivo nezve kiriniki miedzo inotsigirwa neNCI inogona kuwanikwa paNCI yekiriniki miedzo yekutsvaga peji rewebhu. Kliniki miedzo inotsigirwa nemamwe masangano inogona kuwanikwa pane yeClinicalTrials.gov webhusaiti.

Kurapa kwevakuru acute lymphoblastic leukemia kunogona kukonzera mhedzisiro.

Kuti uwane ruzivo nezve mhedzisiro inotanga panguva yekurapa kenza, ona yedu Side Mhedzisiro peji.

Zvimwe zvinokonzeresa kubva pakurapwa nekenza zvinotanga mushure mekurapwa uye kuenderera kwemwedzi kana makore zvinonzi kunonoka kuitika Kwapera nguva mhedzisiro yekurapwa kweVOSE kunogona kusanganisira njodzi yekenza dzechipiri (mhando nyowani dzekenza). Kugara uchitevera-bvunzo kwakakosha kwazvo kune avo vanopona kwenguva refu.

Yekutevera-bvunzo inogona kudikanwa.

Mimwe miedzo yakaitwa kuongorora gomarara kana kutsvaga danho rekenza inogona kudzokororwa. Dzimwe bvunzo dzinodzokororwa kuitira kuti vaone kuti kurapa kuri kushanda sei. Sarudzo nezvekuti uenderere mberi, shandura, kana kumisa kurapwa kunogona kunge kuchibva pamhedzisiro yeiyi bvunzo.

Mimwe bvunzo ichaenderera ichiitwa nguva nenguva mushure mekunge kurapwa kwapera. Mhedzisiro yeiyi bvunzo inogona kuratidza kana mamiriro ako achinja kana kana gomarara radzoka (dzoka). Iyi bvunzo dzimwe nguva inonzi yekuteedzera-bvunzo kana kuongorora-kumusoro.

Kurapa Sarudzo dzeVakuru Acute Lymphoblastic Leukemia

Muchikamu chino

• Asina kurapwa Munhu Mukuru Acute Lymphoblastic Leukemia

• Vakuru Acute Lymphoblastic Leukemia muRuregerero

• Kudzokorora Kwevanhu Vakuru Acute Lymphoblastic Leukemia

Kuti uwane ruzivo nezve marapirwo akanyorwa pazasi, ona iyo Chikamu Sarudzo Yekutarisa Chikamu.

Asina kurapwa Munhu Mukuru Acute Lymphoblastic Leukemia

Kurapa kwakasarudzika kwevakuru acute lymphoblastic leukemia (ZVA) panguva yekuregererwa induction chikamu inosanganisira zvinotevera:

• Kusanganiswa chemotherapy.

• Tyrosine kinase inhibitor therapy ine imatinib mesylate, mune vamwe varwere. Vamwe vevarwere ava vanozove nemubatanidzwa chemotherapy.

• Kuchengeta kwakasimudzira kusanganisira maantibayoti uye tsvuku yeropa uye kuwedzerwa kweplatelet.

• CNS prophylaxis therapy inosanganisira chemotherapy (intrathecal uye / kana systemic) ine kana isina radiation radiation kuropi.

Shandisa yedu kiriniki yekuyedza kutsvaga kutsvaga NCI-yakatsigirwa kenza kiriniki miedzo iri kugamuchira varwere. Unogona kutsvaga miedzo zvichibva parudzi rwecancer, zera remurwere, uye iko kunoitwa miyedzo. Ruzhinji ruzivo nezve zvekuedzwa zvekiriniki zvakare zviripo.

Vakuru Acute Lymphoblastic Leukemia muRuregerero

Kurapa kwakasarudzika kwevanhu vakuru ZVESE muchikamu chekuregererwa chinosanganisira zvinotevera:

• Chemotherapy.

• Tyrosine kinase inhibitor kurapa ne imatinib, nilotinib, kana dasatinib.

• Chemotherapy ne stem cell yekuisa.

• CNS prophylaxis therapy inosanganisira chemotherapy (intrathecal uye / kana systemic) ine kana isina radiation radiation kuropi.

Shandisa yedu kiriniki yekuyedza kutsvaga kutsvaga NCI-yakatsigirwa kenza kiriniki miedzo iri kugamuchira varwere. Unogona kutsvaga miedzo zvichibva parudzi rwecancer, zera remurwere, uye iko kunoitwa miyedzo. Ruzhinji ruzivo nezve zvekuedzwa zvekiriniki zvakare zviripo.

Kudzokorora Kwevanhu Vakuru Acute Lymphoblastic Leukemia

Kurapa kwakasarudzika kwevakuru vanodzoka ZVESE zvinogona kusanganisira zvinotevera:

• Kusanganiswa chemotherapy kunoteverwa ne stem cell transplant.

• Monoclonal antibody therapy (blinatumomab kana inotuzumab ozogamicin) inoteverwa ne stem cell yekuisa.

• Low-dose radiation radiation senzira yekuchengetedza maratidziro ekugadzirisa zviratidzo nekuvandudza hupenyu.

• Tyrosine kinase inhibitor kurapa nedasatinib yevamwe varwere.

Mimwe yemishonga irikudzidzwa mumakiriniki ekuedzwa kwevakuru vanodzoka ZVESE zvinosanganisira zvinotevera:

• Kuongororwa kwekiriniki kweiyo stem cell transplant uchishandisa masero emurwere.

• Kuongororwa kwekiriniki yekurapa kwakanangwa.

• Kuongororwa kwekiriniki kweiyo chimeric antigen receptor (CAR) T-cell kurapa.

• Kuongororwa kwekiriniki kwemishonga mitsva inorwisa cancer.

Shandisa yedu kiriniki yekuyedza kutsvaga kutsvaga NCI-yakatsigirwa kenza kiriniki miedzo iri kugamuchira varwere. Unogona kutsvaga miedzo zvichibva parudzi rwecancer, zera remurwere, uye iko kunoitwa miyedzo. Ruzhinji ruzivo nezve zvekuedzwa zvekiriniki zvakare zviripo.

Kuti Udzidze Zvakawanda Pamusoro peVakuru Acute Lymphoblastic Leukemia

Kuti uwane rumwe ruzivo kubva kuNational Cancer Institute nezve munhu mukuru acute lymphoblastic leukemia, ona zvinotevera:

• Leukemia Peji Peji

• Zvinodhaka Zvinotenderwa kune Acute Lymphoblastic Leukemia

• Ropa-Richigadzira Stem Cell Inoshandura

• Targeted Cancer Therapies

Kuti uwane ruzivo rwekenza uye zvimwe zviwanikwa kubva kuNational Cancer Institute, ona zvinotevera:

• Nezve Kenza

• Stage

• Chemotherapy uye Iwe: Tsigiro Yevanhu Vane Kenza

• Radiation Therapy uye Iwe: Rutsigiro rweVanhu Vane Kenza

• Kurarama neCancer

• Mibvunzo Yekubvunza Wako Chiremba nezveCancer

• Kune Vakapona uye Vanotarisira