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Osteosarcoma uye Malignant Fibrous Histiocytoma yeBone Kurapa (®) -Patient Shanduro

General Ruzivo nezve Osteosarcoma uye Malignant Fibrous Histiocytoma yeBone

PFUNGWA DZINOKOSHA

• Osteosarcoma uye yakaipa malibrous histiocytoma (MFH) yebhonzo ndizvo zvirwere izvo zvinotyisa (cancer) maseru anoumba mupfupa.

• Kuve nekurapwa kwakapfuura nemwaranzi kunogona kuwedzera njodzi yeosteosarcoma.

• Zviratidzo nezviratidzo zve osteosarcoma uye MFH zvinosanganisira kuzvimba pamusoro pefupa kana bhoni chikamu chemuviri uye kurwadza kwemajoini.

• Kufungidzira bvunzo kunoshandiswa kuona (tsvaga) osteosarcoma uye MFH.

• Bhiopsy inoitwa kuti iongorore osteosarcoma.

• Zvimwe zvinhu zvinokanganisa kufungidzira (mukana wekupora) uye sarudzo dzekurapa.

Osteosarcoma uye yakaipa malibrous histiocytoma (MFH) yebhonzo ndizvo zvirwere izvo zvinotyisa (cancer) maseru anoumba mupfupa.

Osteosarcoma kazhinji inotanga muosteoblasts, inova mhando yemapfupa maseru anova matsva emapfupa. Osteosarcoma inowanzoitika mukuyaruka. Inowanzo kuumba kumagumo emapfupa marefu emuviri, ayo anosanganisira mabhonzo emaoko nemakumbo. Muvana nevechiri kuyaruka, inowanzo kuumba mumapfupa marefu, padyo nemabvi. Kazhinji, osteosarcoma inogona kuwanikwa mune zvinyoro nyoro kana nhengo mubhokisi kana mudumbu.

Osteosarcoma ndiyo yakajairika mhando yekenza yemapfupa. Yakashata fibrous histiocytoma (MFH) yebhonzo ibundu risinganzwisisike repfupa. Inobatwa se osteosarcoma.

Ewing sarcoma ndeimwe mhando yekenza yemapfupa, asi haina kuvharwa muchidimbu ichi. Ona pfupiso ye nezve Ewing Sarcoma Kurapa kuti uwane rumwe ruzivo.

Kuve nekurapwa kwakapfuura nemwaranzi kunogona kuwedzera njodzi yeosteosarcoma.

Chero chipi zvacho chinowedzera njodzi yako yekuwana chirwere chinonzi njodzi chinhu. Kuva nenjodzi hazvireve kuti uchawana gomarara; kusava nenjodzi hazvireve kuti hauzobatwe negomarara. Taura nachiremba wemwana wako kana iwe uchifunga kuti mwana wako angave ari panjodzi. Njodzi zvinhu zve osteosarcoma zvinosanganisira zvinotevera:

• Kurapa kwekare ne radiation radiation.

• Kurapa kwekare nemishonga yeanticancer inonzi alkylating agents.

• Kuve neimwe shanduko muRB1 geni.

• Kuva nemimwe mamiriro, akadai seanotevera:

• Bloom chirwere.

• Diamond-Blackfan kupererwa neropa.

• Li-Fraumeni chirwere.

• Chirwere chepaget.

• Nhaka retinoblastoma.

• Rothmund-Thomson chirwere.

• Werner chirwere.

Zviratidzo nezviratidzo zve osteosarcoma uye MFH zvinosanganisira kuzvimba pamusoro pefupa kana bhoni chikamu chemuviri uye kurwadza kwemajoini.

Izvi nezvimwe zviratidzo uye zviratidzo zvinogona kukonzerwa neosteosarcoma kana MFH kana nemamwe mamiriro. Tarisa nachiremba kana mwana wako aine chero chinotevera:

• Kuzvimba pamusoro pabhonzo kana bhonzo chikamu chemuviri.

• Marwadzo mupfupa kana mubatanidzwa.

• Bhonzo rinotyoka pasina chikonzero chinozivikanwa.

Kufungidzira bvunzo kunoshandiswa kuona (tsvaga) osteosarcoma uye MFH.

Kufungidzira bvunzo kunoitwa pasati paita biopsy. Iyi inotevera bvunzo uye maitiro anogona kushandiswa:

• Kuongorora kwepanyama uye nhoroondo: Kuongororwa kwemuviri kutarisa zviratidzo zvehutano, kusanganisira kuongorora zviratidzo zvehosha, zvakadai semapundu kana chero chinhu chinoratidzika sechisina kujairika. Nhoroondo yemaitiro ehutano hwemurwere uye kurwara kwakapfuura uye kurapwa kuchatorwawo.

• X-ray: X-ray yenhengo nemapfupa mukati memuviri. X-ray imhando yesimba remagetsi rinogona kupfuura nemuviri uye kupinda mufirimu, richiita mufananidzo wenzvimbo dziri mukati memuviri.

• CT scan (CAT scan): Maitiro anoita akateedzana emifananidzo yakajeka yenzvimbo dziri mukati memuviri, inotorwa kubva kumakona akasiyana. Mifananidzo yacho inogadzirwa nekombuta yakabatana neiyo x-ray muchina. Dhayi inogona kuiswa jekiseni kana kumedzwa kubatsira nhengo kana zvinyama kuratidza zvakajeka. Iyi nzira inonziwo computed tomography, computerized tomography, kana komputa axial tomography.

• MRI (magnetic resonance imaging): Maitiro anoshandisa magineti, masaisai eredhiyo, uye komputa kugadzira yakateedzana mifananidzo yakajeka yenzvimbo dziri mukati memuviri. Iyi nzira inonziwo nyukireya magnetic resonance imaging (NMRI).

Bhiopsy inoitwa kuti iongorore osteosarcoma.

Masero uye zvinyama zvinobviswa panguva yebiopsy kuitira kuti zvionekwe pasi pe microscope nachiremba wekutarisa zviratidzo zvecancer. Izvo zvakakosha kuti biopsy iitwe nachiremba anovhiya uyo ari nyanzvi pakurapa gomarara repfupa. Zvakanakisa kana chiremba anovhiya ariyewo anobvisa bundu. Iyo biopsy uye kuvhiya kubvisa bundu zvakarongwa pamwechete. Nzira iyo biopsy inoitwa inobata kuti ndeupi rudzi rwekuvhiya kunogona kuitwa gare gare.

Mhando yebhiopsy inoitwa ichave yakavakirwa pahukuru hwebundu uye kwariri mumuviri. Kune mhando mbiri dzebiopsy dzinogona kushandiswa:

• Core biopsy: Kubviswa kwetishu uchishandisa tsono yakafara.

• Incisional biopsy: Kubviswa kwechikamu chebundu kana sampuro yetishu isingaite kunge yakajairika.

Muedzo unotevera unogona kuitwa munyama inobviswa:

• Electron microscopy: Kuongororwa kwerabhoritari umo masero ari mune imwe sampuro yetishu anotariswa pasi pemaitiro akareba uye ane simba-rakakura kuti atarise kumwe kushanduka mumasero.

Zvimwe zvinhu zvinokanganisa kufungidzira (mukana wekupora) uye sarudzo dzekurapa.

Kufungidzira (mukana wekupora) kunokanganiswa nezvimwe zvinhu usati uye mushure mekurapwa.

Iko kufungidzira kweasina kurapwa osteosarcoma uye MFH zvinoenderana nezvinotevera:

• Iko iko bundu riri mumuviri uye kana mamota akaumbwa mune anopfuura rimwe pfupa.

• Kukura kwebundu.

• Kunyangwe gomarara rapararira kune dzimwe nhengo dzemuviri uye kwarakapararira.

• Rudzi rwebundu (zvinoenderana nekuti maseru ekenza anotaridzika sei pasi pe microscope).

• Zera remurwere uye huremu panguva yekuongororwa.

• Kunyangwe murwere akarapwa gomarara rakasiyana.

• Kunyangwe bundu racho rakonzera kutyora pfupa.

• Kunyangwe murwere ane zvimwe zvirwere zvemagene.

Mushure mokunge osteosarcoma kana MFH inorapwa, kufungidzira kunobvawo pane zvinotevera:

• Yakawanda sei kenza yakaurayiwa nekemotherapy.

• Yakawanda sei iyo bundu yakabviswa nekuvhiyiwa.

• Kunyangwe kenza yakadzokazve (kudzoka) mukati memakore maviri ekuongororwa.

Kurapa sarudzo yeosteosarcoma uye MFH zvinoenderana nezvinotevera:

• Iko iko bundu riri mumuviri.

• Kukura kwebundu.

• Chikamu uye giredhi rekenza.

• Kunyangwe mapfupa achiri kukura.

• Zera remurwere uye hutano hwese.

• Chido chemurwere uye chemhuri kuti murwere agone kutora chikamu muzviitiko zvakaita semitambo kana kutarisa neimwe nzira.

• Kunyangwe kenza ichangobva kuongororwa kana kuti yakadzokazve mushure mekurapwa.

Matanho eOsteosarcoma uye Malignant Fibrous Histiocytoma yeBone

PFUNGWA DZINOKOSHA

• Mushure mokunge osteosarcoma kana yakaipa fibrous histiocytoma (MFH) yaonekwa, miedzo inoitwa kuti uone kana gomarara maseru rapararira kune dzimwe nhengo dzemuviri.

• Pane nzira nhatu dzinopararira negomarara mumuviri.

• Gomarara rinogona kutapukira kubva kwarakatanga kuenda kune dzimwe nhengo dzemuviri.

• Osteosarcoma uye MFH zvinotsanangurwa seinowanikwa munharaunda kana metastatic.

Mushure mokunge osteosarcoma kana yakaipa fibrous histiocytoma (MFH) yaonekwa, miedzo inoitwa kuti uone kana gomarara maseru rapararira kune dzimwe nhengo dzemuviri.

Maitiro anoshandiswa kutsvaga kana gomarara rapararira kune dzimwe nhengo dzemuviri anonzi staging. Kune osteosarcoma uye yakaipa malibrous histiocytoma (MFH), varwere vazhinji vakaiswa mumapoka zvinoenderana nekuti kenza inowanika muchikamu chimwe chete chemuviri (munzvimbo) kana yakapararira (metastatic).

Iyi inotevera bvunzo uye maitiro anogona kushandiswa:

• X-ray: X-ray yenhengo, senge chipfuva, nemapfupa mukati memuviri. X-ray imhando yesimba remagetsi rinogona kupfuura nemuviri uye kupinda mufirimu, richiita mufananidzo wenzvimbo dziri mukati memuviri. X-ray ichatorwa yechipfuva nenzvimbo pakaumbwa bundu.

• CT scan (CAT scan): Maitiro anoita akateedzana emifananidzo yakajeka yenzvimbo dziri mukati memuviri, senge chipfuva, chakatorwa kubva kumakona akasiyana. Mifananidzo yacho inogadzirwa nekombuta yakabatana neiyo x-ray muchina. Dhayi inogona kuiswa jekiseni kana kumedzwa kubatsira nhengo kana zvinyama kuratidza zvakajeka. Iyi nzira inonziwo computed tomography, computerized tomography, kana komputa axial tomography. Mifananidzo ichatorwa yechipfuva uye nenzvimbo pakaumbwa bundu.

• PET-CT scan: Maitiro anosanganisa iyo mifananidzo kubva kune positron emission tomography (PET) scan uye computed tomography (CT) scan. Iyo PET neCT scan inoitwa panguva imwe chete pamushini mumwe chete. Mifananidzo kubva kumatanho maviri akabatanidzwa kuti iite yakadzama pikicha kupfuura chero bvunzo yaingaite yega. PET scan ndiyo nzira yekuwana yakaipa malone maseru mumuviri. Chishoma che radioactive glucose (shuga) inoiswa mutsinga. Iyo PET scanner inotenderera yakatenderedza muviri uye inogadzira mufananidzo wepo glucose iri kushandiswa mumuviri. Malignant tumarara maseru anoratidza kupenya mumufananidzo nekuti anoshanda uye anotora glucose yakawanda kupfuura zvinoita maseru akajairwa.

• MRI (magnetic resonance imaging): Maitiro anoshandisa magineti, masaisai eredhiyo, uye komputa kugadzira yakateedzana mifananidzo yakajeka yenzvimbo dziri mukati memuviri. Iyi nzira inonziwo nyukireya magnetic resonance imaging (NMRI).

• Bone scan: Maitiro ekutarisa kana paine nekukurumidza kupatsanura masero, senge kenza maseru, mupfupa. Chinhu chidiki kwazvo che radioactive chakabayiwa mutsinga uye chinofamba neropa. Iyo radioactive zvinhu inounganidza mumapfupa nekenza uye inoonekwa ne scanner.

Pane nzira nhatu dzinopararira negomarara mumuviri.

Kenza inogona kupararira kuburikidza nematinji, iyo lymph system, uye neropa:

• Tishu. Kenza inopararira kubva kwayakatanga nekukura ichipinda munzvimbo dziri pedyo.

• Lymph maitiro. Kenza inopararira kubva kwayakatanga nekupinda muiyo lymph system. Kenza inofamba nemumidziyo yema lymph ichienda kune dzimwe nhengo dzemuviri.

• Ropa. Kenza inopararira kubva payakatanga nekupinda muropa. Kenza inofamba nemidzi yeropa ichienda kune dzimwe nhengo dzemuviri.

Gomarara rinogona kutapukira kubva kwarakatanga kuenda kune dzimwe nhengo dzemuviri.

Kana kenza ikapararira kune chimwe chikamu chemuviri, inonzi metastasis. Cancer maseru anotsemuka kubva kwaakatanga (iro bundu rekutanga) uye achifamba kuburikidza neye lymph system kana ropa.

• Lymph maitiro. Gomarara rinopinda mu "lymph system", rinofamba nemumidziyo ye "lymph", uye rinogadzira bundu (metastatic tumor) mune chimwe chikamu chemuviri.

• Ropa. Kenza inopinda muropa, inofamba nemutsinga dzeropa, yoita bundu (metastatic tumor) mune chimwe chikamu chemuviri.

Iyo metastatic bundu irwo rudzi rwecancer seyakanyanya bundu. Semuenzaniso, kana osteosarcoma ichipararira kumapapu, masero ekenza mumapapu ari masero eosteosarcoma. Hosha iyi metastatic osteosarcoma, kwete kenza yemapapu.

Osteosarcoma uye MFH zvinotsanangurwa seinowanikwa munharaunda kana metastatic.

• Yakasarudzika osteosarcoma kana MFH haina kupararira kunze kwepfupa kwakatangira kenza. Panogona kuve nenzvimbo imwe kana dzinopfuura dzegomarara mufupa dzinogona kubviswa panguva yekuvhiyiwa.

• Metastatic osteosarcoma kana MFH yakapararira kubva pfupa umo kenza yakatanga kune dzimwe nhengo dzemuviri. Gomarara rinowanzopararira kumapapu. Inogonawo kupararira kune mamwe mapfupa.

Dzokororo Osteosarcoma uye Malignant Fibrous Histiocytoma yeBone

Kazhinji osteosarcoma uye yakaipa malibrous histiocytoma (MFH) yemapfupa kenza dzakadzokazve (dzoka) mushure mekurapwa. Gomarara rinogona kudzoka mupfupa kana mune mamwe mativi emuviri. Osteosarcoma uye MFH kazhinji zvinodzoka mumapapu, pfupa, kana zvese zviri zviviri. Apo osteosarcoma inodzokazve, inowanzove mukati memwedzi gumi nemana mushure mekurapwa kwapera.

Kurapa Sarudzo Kuongorora

PFUNGWA DZINOKOSHA

• Kune akasiyana marudzi ekurapa kwevarwere vane osteosarcoma kana yakaipa malibrous histiocytoma (MFH) yebhonzo.

• Vana vane osteosarcoma kana MFH vanofanirwa kurapwa kwavo kuchirongwa nechikwata chevanoona nezvehutano vari nyanzvi pakurapa kenza muvana.

• Kurapa kweosteosarcoma kana yakaipa fibrous histiocytoma inogona kukonzera mhedzisiro.

• Mhando shanu dzekurapwa kwakajairika dzinoshandiswa:

• Kuvhiya

• Chemotherapy

• Radiation kurapa

• Samarium

• Targeted kurapwa

• Mhando nyowani dzekurapa dziri kuyedzwa mumakiriniki ekuedzwa.

• Varwere vangangoda kufunga nezve kutora chikamu mukutora kiriniki.

• Varwere vanogona kupinda mumakiriniki miedzo vasati, panguva, kana mushure mekutanga kwavo kenza kurapwa.

• Yekutevera-bvunzo inogona kudikanwa.

Kune akasiyana marudzi ekurapa kwevarwere vane osteosarcoma kana yakaipa malibrous histiocytoma (MFH) yebhonzo.

Mhando dzakasiyana dzekurapa dzinowanikwa kune vana vane osteosarcoma kana yakaipa malibrous histiocytoma (MFH) yebhonzo. Mamwe marapirwo akajairwa (iko kurapwa kwazvino kwashandiswa), uye kumwe kuedzwa mumakiriniki ekuedzwa A kurapwa kiriniki kuyedzwa chidzidzo chekutsvaga chakaitirwa kubatsira kuvandudza marapirwo azvino kana kuwana ruzivo marapirwo matsva evarwere vane gomarara. Kana kiriniki miedzo ikaratidza kuti kurapwa kutsva kuri nani pane kwese kurapwa, kurapwa kutsva kunogona kuve kwakajairwa kurapwa.

Nekuti kenza muvana isingawanzo, kutora chikamu mukutongwa kwekiriniki kunofanirwa kutariswa. Mimwe miedzo yekiriniki yakavhurwa chete kune varwere vasina kutanga kurapwa.

Vana vane osteosarcoma kana MFH vanofanirwa kurapwa kwavo kuchirongwa nechikwata chevanoona nezvehutano vari nyanzvi pakurapa kenza muvana.

Kurapa kunozoonekwa nachiremba wevana oncologist, chiremba ane hunyanzvi hwekurapa vana vane gomarara. Oncologist wevana anoshanda pamwe nevamwe vanopa rubatsiro rwehutano hwevana avo vari nyanzvi pakurapa osteosarcoma uye MFH uye vanoziva mune dzimwe nzvimbo dzemishonga. Izvi zvinogona kusanganisira vanachiremba vanotevera:

• Chiremba wevana.

• Chiremba wemapfupa ane ruzivo rwekurapa mapundu emapfupa.

• Radiation oncologist.

• Rehabilitation nyanzvi.

• Mukoti wechiremba nyanzvi.

• Wezvemagariro.

• Mwana-hupenyu nyanzvi.

• Nyanzvi yezvepfungwa.

Kurapa kweosteosarcoma kana yakaipa fibrous histiocytoma inogona kukonzera mhedzisiro.

Kuti uwane ruzivo nezve mhedzisiro inotanga panguva yekurapa kenza, ona yedu Side Mhedzisiro peji.

Zvimwe zvinokonzeresa kubva pakurapwa nekenza zvinotanga mushure mekurapwa uye kuenderera kwemwedzi kana makore zvinonzi kunonoka kuitika Mhedzisiro mhedzisiro yekurapwa nekenza inogona kusanganisira zvinotevera:

• Zvinetso zvepanyama.

• Shanduko mumanzwiro, manzwiro, kufunga, kudzidza, kana ndangariro.

• Gomarara repiri (mhando nyowani dzekenza).

Mimwe mhedzisiro mhedzisiro inogona kurapwa kana kudzorwa. Izvo zvakakosha kuti utaure navanachiremba vemwana wako nezve mhedzisiro yekurapwa nekenza kunogona kuve pamwana wako. (Ona pfupiso ye pamusoro peMagumo Ekurapa kweKenza Yevacheche kuti uwane rumwe ruzivo).

Mhando shanu dzekurapwa kwakajairika dzinoshandiswa:

Kuvhiya

Kuvhiya kubvisa bundu rose kuchaitwa kana zvichibvira. Chemotherapy inogona kupihwa usati wavhiyiwa kuita kuti bundu riite diki. Izvi zvinonzi neoadjuvant chemotherapy. Chemotherapy inopihwa mashoma mapfupa tishu anoda kubviswa uye kune mashoma matambudziko mushure mekuvhiyiwa.

Aya anotevera marudzi ekuvhiya anogona kuitwa:

• Kunakidzwa kwese kwenzvimbo: Kuvhiya kubvisa kenza uye mamwe materu ane hutano pairi.

• Kuvhiya kwemaoko nemakumbo: Kubvisa bundu mune imwe nhengo (ruoko kana gumbo) pasina kudimburwa, saka kushandiswa uye kutaridzika kwegumbo kunoponeswa. Vazhinji varwere vane osteosarcoma mune imwe nhengo vanogona kurapwa ne-limb-rega kuvhiya. Bundu racho rinobviswa nehupamhi hwekunze kwemuno. Nyama uye pfupa izvo zvinobviswa zvinogona kutsiviwa nechomira uchishandisa tinyama uye pfupa rinotorwa kubva kune chimwe chikamu chemuviri wemurwere, kana neyakaiswa senge rakagadzirwa bone. Kana kuputsika kukawanikwa panguva yekuongororwa kana panguva yekemotherapy pamberi pekuvhiyiwa, kuvhiyiwa kwemakumbo kana maoko kunogona kuitika mune dzimwe nguva. Kana iye anovhiya asingakwanise kubvisa bundu rose uye nyama yakakwana ine hutano yakatenderedza, kudimburwa kunogona kuitwa.

• Kudimburwa: Kuvhiya kubvisa chikamu kana ruoko rwese kana gumbo. Izvi zvinogona kuitwa kana zvisingaite kubvisa bundu rese mukuvhiya kwemaoko nemakumbo. Murwere anogona kuve akagadzirwa neprosthesis (yekuisira nhengo) mushure mekudimburwa.

• Rotationplasty: Kuvhiya kubvisa bundu uye bondo rakabatana. Chikamu chegumbo chinosara pazasi pebvi chinobva chasungirirwa pachikamu chegumbo rinosara pamusoro pebvi, netsoka yakatarisa kumashure uye gumbo richiita sebvi. Prosthesis inogona kuzonamatira kutsoka.

Zvidzidzo zvakaratidza kuti kupona kwakafanana kunyangwe kuvhiya kwekutanga kwakaitwa kuvhiya kwemaoko kana kudimburwa.

Mushure mekunge chiremba abvisa kenza yese inoonekwa panguva yekuvhiyiwa, varwere vanopihwa chemotherapy yekuuraya chero masero egomarara akasara munzvimbo yakabviswa bundu kana kuti akapararira kune dzimwe nhengo dzemuviri. Mushonga wakapihwa mushure mekuvhiyiwa, kudzikisa njodzi yekuti gomarara richadzoka, inonzi adjuvant therapy.

Chemotherapy

Chemotherapy mushonga wekenza unoshandisa mishonga kumisa kukura kwemasero ekenza, kungave nekuuraya maseru kana nekuamisa iwo kubva pakupatsanuka. Kana chemotherapy ikatorwa nemuromo kana kujowa mutsinga kana mhasuru, mishonga inopinda muropa uye inogona kusvika masero emukenza mumuviri wese (systemic chemotherapy). Kana chemotherapy ikaiswa yakanangana necerebrospinal fluid, nhengo, kana dumbu remuviri senge dumbu, iwo madhiragi anonyanya kukanganisa cancer maseru munzvimbo idzodzo (remunharaunda chemotherapy).

Kusanganisa chemotherapy ndiko kushandiswa kweanopfuura imwe anticancer mushonga.

Systemic chemotherapy inoshandiswa kurapa osteosarcoma uye MFH yebhonzo. Chemotherapy inowanzo kupihwa usati uye mushure mekuvhiyiwa kubvisa bundu rekutanga.

Ona Mishonga Inotenderwa Bone Cancer kuti uwane rumwe ruzivo.

Radiation kurapa

Radiation kurapa kurapwa kenza iyo inoshandisa yakakwira-simba x-rays kana mamwe marudzi e radiation kuuraya cancer maseru kana kuachengeta iwo kuti asakure. Kune mhando mbiri dze radiation radiation:

• External radiation therapy inoshandisa muchina uri kunze kwemuviri kutumira radiation kune kenza.

• Yemukati radiation kurapwa kunoshandisa radioactive chinhu chakavharirwa mune tsono, mhodzi, waya, kana makateti anoiswa akananga mukati kana padyo nekenza.

External radiation therapy inoshandiswa kurapa osteosarcoma uye MFH yebhonzo.

Osteosarcoma uye MFH maseru haaurayiwe nyore nevekunze radiation kurapwa. Inogona kushandiswa kana kenza shoma yasara mushure mekuvhiyiwa kana kushandiswa pamwechete nemamwe marapirwo.

Samarium

Samarium mushonga unouraya mwenje unonongedza nzvimbo dziri kukura maseru emapfupa, senge mamota maseru mupfupa. Inobatsira kubvisa marwadzo anokonzerwa nekenza mupfupa uyezve inouraya masero eropa mumongo wemapfupa. Iyo zvakare inoshandiswa kurapa osteosarcoma iyo yakadzoka mushure mekurapa mune rakasiyana pfupa.

Kurapa ne samarium kunogona kuteverwa ne stem cell kuisirwa. Usati warapwa nesamarium, masero emadzinde (masero eropa asina kusimba) anobviswa muropa kana mwongo wemapfupa emurwere uye akaomeswa nechando uye akachengetwa. Mushure mekurapwa ne samarium kwapera, maseru akachengetwa anonyungudutswa uye ndokudzoserwa kumurwere kuburikidza nekumukiswa. Aya akadzikiswa maseru emadzinde anokura kuita (uye kudzoreredza) masero eropa emuviri.

Targeted kurapwa

Targeted kurapwa kurapwa kunoshandisa zvinodhaka kana zvimwe zvinhu kuti uwane nekurwisa chaiwo maseru ekenza pasina kukuvadza zvakajairika maseru. Kune akasiyana marudzi eakanangwa kurapa ari kushandiswa kurapa osteosarcoma kana kudzidza mumakiriniki ekuedzwa:

• Kinase inhibitor therapy inovhara puroteni inodiwa kuti maseru ekenza apatsanuke. Sorafenib imhando yekinase inhibitor kurapa inoshandiswa kurapa zvinowanzoitika osteosarcoma.

• Mamia mamalia's rapamycin (mTOR) inhibitors anovharira protein inonzi mTOR, inogona kuchengetedza maseru emukenza kukura uye kudzivirira kukura kwemidziyo yeropa mitsva inoda kukura. Everolimus ndeye mTOR inhibitor inoshandiswa kurapa zvakare osteosarcoma.

• Monoclonal antibody therapy ndeye kenza kurapa iyo inoshandisa masoja akagadzirwa murabhoritari, kubva kune imwechete mhando yemasoja ekudzivirira maseru. Aya ma antibodies anokwanisa kuona zvinhu pane cancer cancer kana zvakajairika zvinhu zvinogona kubatsira gomarara maseru kukura. Masoja ekudzivirira chirwere anonamira pazvinhu uye anouraya maseru egomarara, anovharira kukura kwawo, kana kuti aachengetedze kubva pakupararira. Monoclonal antibodies inopihwa nekumisirwa. Inogona kushandiswa yoga kana kutakura zvinodhaka, chepfu, kana zvinhu zvine radioactive zvakanangana nemasero ekenza. Denosumab uye dinutuximab ndiwo monoclonal antibodies ari kuongororwa kuitira kurapwa kweakajairwa osteosarcoma.

Mhando nyowani dzekurapa dziri kuyedzwa mumakiriniki ekuedzwa.

Ruzivo nezve inoenderera kiriniki miedzo inowanikwa kubva kuCI webhusaiti

Varwere vangangoda kufunga nezve kutora chikamu mukutora kiriniki.

Kune vamwe varwere, kutora chikamu mumuedzo wekiriniki inogona kunge iri sarudzo yekurapa yakanyanya kunaka. Kliniki miedzo chikamu chekenza tsvagiridzo. Zvemakiriniki miedzo inoitwa kuti uone kana marapirwo matsva egomarara akachengeteka uye achishanda kana zvirinani pane akajairwa kurapwa.

Mazhinji emazuva ano marapirwo akajairwa ekenza akavakirwa pamavambo emakiriniki ekuedzwa. Varwere vanotora chikamu mukuyedzwa kwekiriniki vanogona kuwana kurapwa kwakaringana kana kuve pakati pevekutanga kurapwa kutsva.

Varwere vanotora chikamu mumiedzo yekiriniki zvakare vanobatsira kugadzirisa marapirwo achaitwa kenza mune ramangwana. Kunyangwe kana miedzo yemakiriniki isinga tangire kumarapirwo matsva anoshanda, anowanzo pindura mibvunzo yakakosha uye anobatsira kufambisira mberi kutsvagurudza.

Varwere vanogona kupinda mumakiriniki miedzo vasati, panguva, kana mushure mekutanga kwavo kenza kurapwa.

Mimwe miedzo yekiriniki inosanganisira chete varwere vasati vagamuchira kurapwa. Mimwe miedzo yekuedza kurapwa kwevarwere vane kenza haina kuve nani. Kune mamwezve emakiriniki miedzo inoedza nzira nyowani dzekumisa cancer kubva kudzokororazve (kudzoka) kana kudzikisira mhedzisiro yemakenza kurapwa.

Kuedzwa kwemakiriniki kuri kuitika munzvimbo zhinji dzenyika. Ruzivo nezve kiriniki miedzo inotsigirwa neNCI inogona kuwanikwa paNCI yekiriniki miedzo yekutsvaga peji rewebhu. Kliniki miedzo inotsigirwa nemamwe masangano inogona kuwanikwa pane yeClinicalTrials.gov webhusaiti.

Yekutevera-bvunzo inogona kudikanwa.

Mimwe miedzo yakaitwa kuongorora gomarara kana kutsvaga danho rekenza inogona kudzokororwa. Dzimwe bvunzo dzinodzokororwa kuitira kuti vaone kuti kurapa kuri kushanda sei. Sarudzo nezvekuti uenderere mberi, shandura, kana kumisa kurapwa kunogona kunge kuchibva pamhedzisiro yeiyi bvunzo.

Mimwe bvunzo ichaenderera ichiitwa nguva nenguva mushure mekunge kurapwa kwapera. Mhedzisiro yeiyi bvunzo inogona kuratidza kana mamiriro emwana wako achinja kana kana gomarara radzoka (dzoka). Iyi bvunzo dzimwe nguva inonzi yekuteedzera-bvunzo kana kuongorora-kumusoro.

Kurapa Sarudzo dzeOsteosarcoma uye Malignant Fibrous Histiocytoma yeBone

Muchikamu chino

• Yakawanikwa Osteosarcoma uye Malignant Fibrous Histiocytoma yeBone

• Metastatic Osteosarcoma uye Malignant Fibrous Histiocytoma yeBone

• Dzokororo Osteosarcoma uye Malignant Fibrous Histiocytoma yeBone

Kuti uwane ruzivo nezve marapirwo akanyorwa pazasi, ona iyo Chikamu Sarudzo Yekutarisa Chikamu.

Yakawanikwa Osteosarcoma uye Malignant Fibrous Histiocytoma yeBone

Kurapa kunogona kusanganisira zvinotevera:

• Kuvhiya kubvisa bundu rekutanga.

• Chemotherapy inogona kupihwa usati kana mushure mekuvhiyiwa kubvisa bundu rekutanga.

• Radiation kurapwa kana kuvhiya kusingagone kuitwa kana kana bundu racho risina kubviswa zvachose nekuvhiyiwa.

Shandisa yedu kiriniki yekuyedza kutsvaga kutsvaga NCI-yakatsigirwa kenza kiriniki miedzo iri kugamuchira varwere. Unogona kutsvaga miedzo zvichibva parudzi rwecancer, zera remurwere, uye iko kunoitwa miyedzo. Ruzhinji ruzivo nezve zvekuedzwa zvekiriniki zvakare zviripo.

Metastatic Osteosarcoma uye Malignant Fibrous Histiocytoma yeBone

Lung Metastasis

Kana osteosarcoma kana yakaipa fibrous histiocytoma (MFH) ichipararira, inowanzo pararira kumapapu. Kurapa kweosteosarcoma uye MFH nemapapu metastasis kunogona kusanganisira zvinotevera:

• Chemotherapy inoteverwa nekuvhiya kubvisa gomarara rekutanga uye gomarara rapararira kumapapu.

Bone Metastasis kana Bone neLung Metastasis

Osteosarcoma uye yakaipa fibrous histiocytoma inogona kupararira kune pfupa riri kure uye / kana mapapu. Kurapa kunogona kusanganisira zvinotevera:

• Chemotherapy inoteverwa nekuvhiya kubvisa bundu rekutanga uye gomarara rapararira kune dzimwe nhengo dzemuviri. More chemotherapy inopihwa mushure mekuvhiyiwa.

• Kuvhiya kubvisa bundu rekutanga, kuchiteverwa nekemotherapy uye kuvhiyiwa kubvisa kenza yakapararira kune dzimwe nhengo dzomuviri.

Shandisa yedu kiriniki yekuyedza kutsvaga kutsvaga NCI-yakatsigirwa kenza kiriniki miedzo iri kugamuchira varwere. Unogona kutsvaga miedzo zvichibva parudzi rwecancer, zera remurwere, uye iko kunoitwa miyedzo. Ruzhinji ruzivo nezve zvekuedzwa zvekiriniki zvakare zviripo.

Dzokororo Osteosarcoma uye Malignant Fibrous Histiocytoma yeBone

Kurapa kweakajairwa osteosarcoma uye yakaipa malibrous histiocytoma yemapfupa inogona kusanganisira zvinotevera:

• Kuvhiya kubvisa gomarara rapararira kune dzimwe nhengo dzemuviri.

• Chemotherapy.

• Kune mamota ayo adzokazve mupfupa chete, samarium ine kana isina stem cell yekuisa uchishandisa murwere masisitimu maseru, senzira yekurapa yekudzora marwadzo uye nekuvandudza hupenyu hwehupenyu.

• Targeted Therapy (sorafenib kana everolimus).

• Radiation kurapa senge palliative kurapwa kubvisa zviratidzo uye nekuvandudza hupenyu hwehupenyu.

• Kuongororwa kwekiriniki kunoongorora muyenzaniso wemota yemurwere kune mamwe magene ekuchinja. Rudzi rwekurapa kwakanangwa kuchapihwa kumurwere kunoenderana nerudzi rwechinjo yemajini.

• Kuongororwa kwekiriniki yemhando nyowani yekurapa kwevarwere vane gomarara risingakwanise kubviswa nekuvhiyiwa. Izvi zvinogona kusanganisira kurapwa kwakanangwa senge monoclonal antibody therapy.

Shandisa yedu kiriniki yekuyedza kutsvaga kutsvaga NCI-yakatsigirwa kenza kiriniki miedzo iri kugamuchira varwere. Unogona kutsvaga miedzo zvichibva parudzi rwecancer, zera remurwere, uye iko kunoitwa miyedzo. Ruzhinji ruzivo nezve zvekuedzwa zvekiriniki zvakare zviripo.

Kuti Udzidze Zvakawanda Nezve Osteosarcoma uye Malignant Fibrous Histiocytoma yeBone

Kuti uwane rumwe ruzivo kubva kuNational Cancer Institute nezve osteosarcoma uye yakaipa malibrous histiocytoma yebhonzo, ona zvinotevera:

• Bone Cancer Kumba Peji

• Computed Tomography (CT) Scans uye Cancer

• Mishonga Inotenderwa Bone Cancer

• Targeted Cancer Therapies

• Kenza Bone

Kuti uwane rumwe ruzivo rwegomarara rehucheche uye zvimwe zvecancer zviwanikwa, ona zvinotevera:

• Nezve Kenza

• Cancers Yevacheche

• Kurapa Kutsvaga Kwevana Cancer Buda Disclaimer

• Mahedhi Ekupedzisira Ekurapwa kweKenza Yevacheche

• Vechidiki uye Vechidiki Vakuru vane Cancer

• Vana vane Cancer: Nhungamiro Yevabereki

• Kenza muVana neVachiri kuyaruka

• Stage

• Kurarama neCancer

• Mibvunzo Yekubvunza Wako Chiremba nezveCancer

• Kune Vakapona uye Vanotarisira