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Ewing Sarcoma Kurapa

Ruzivo Ruzhinji Nezve Ewing Sarcoma

PFUNGWA DZINOKOSHA

• Kuchera sarcoma rudzi rwebundu rinoumba mumapfupa kana munyoro.

• Undifferentiated denderedzwa sero sarcoma inogona zvakare kuitika mune bone kana yakapfava nyama.

• Zviratidzo nezviratidzo zveEwing sarcoma zvinosanganisira kuzvimba uye kurwadziwa padhuze nebundu.

• Kuyedza kunoongorora bone uye zvinyoro nyoro zvinoshandiswa kuongorora uye danho Ewing sarcoma.

• Biopsy inoitwa kuongorora Ewing sarcoma.

• Zvimwe zvinhu zvinokanganisa kufungidzira (mukana wekupora).

Kuchera sarcoma rudzi rwebundu rinoumba mumapfupa kana munyoro.

Kuchera sarcoma rudzi rwebundu rinoumba kubva kune imwe mhando yesero mupfupa kana zvinyoro zvinyoro. Kuchera sarcoma kunogona kuwanikwa mumapfupa emakumbo, maoko, tsoka, maoko, chifuva, chiuno, musana kana dehenya. Ewing sarcoma zvakare inogona kuwanikwa mune yakapfava tishu ye trunk, maoko, makumbo, musoro, mutsipa, retroperitoneum (nzvimbo iri kuseri kwedumbu kuseri kwetissue inokwenya madziro emudumbu uye inovhara mitezo mizhinji mudumbu), kana dzimwe nzvimbo.

Kutora sarcoma kunowanzoitika muvachiri kuyaruka uye vechidiki vechidiki (vechidiki kusvika pakati pe20s).

Ewing sarcoma yave ichinziwo periipheral chinyakare neuroectodermal bundu, Askin bundu (Ewing sarcoma yechipfuva madziro), extraosseous Ewing sarcoma (Ewing sarcoma mune zvinyama zvisiri bone), uye Ewing sarcoma mhuri yemamota.

Undifferentiated denderedzwa sero sarcoma inogona zvakare kuitika mune bone kana yakapfava nyama.

Undifferentiated round sero sarcoma inowanzoitika mumapfupa kana mhasuru dzakabatanidzwa nemapfupa uye izvo zvinobatsira muviri kufamba. Kune maviri marudzi easina kusarudzika kutenderera sero sarcoma iyo inorapwa seEwing sarcoma:

• Undifferentiated denderedzwa sero sarcoma neBcOR-CCNB3 kugadzirisazve. Rudzi urwu rwebundu remapfupa kazhinji runoumbika muchiuno, maoko, kana makumbo. Inogona kupararira kune dzimwe nhengo dzomuviri. Mune irwo rudzi rwekutenderera sero sarcoma, iyo BCOR geni rakabatanidzwa kune CCNB3 geni. Kuti uongorore denderedzwa sero sarcoma, mamota maseru anoongororwa kune iyi geni shanduko.

• Undifferentiated denderedzwa sero sarcoma neCIC-DUX4 rearrangements. Rudzi urwu rwezvinyoro zvinyama bundu rinowanzo kuumba mutangi, maoko, kana makumbo. Inowanzoitika muvanhurume uye mune vechidiki vechidiki vari pakati pemakore makumi maviri nemana kusvika makumi mana ekuberekwa. Mune iyi mhando yekutenderera sero sarcoma, iyo CIC geni inosanganiswa kune iyo DUX4 geni. Kuti uongorore denderedzwa sero sarcoma, mamota maseru anoongororwa kune iyi geni shanduko.

Zviratidzo nezviratidzo zveEwing sarcoma zvinosanganisira kuzvimba uye kurwadziwa padhuze nebundu.

Izvi nezvimwe zviratidzo uye zviratidzo zvinogona kukonzerwa neEwing sarcoma kana nemamwe mamiriro. Tarisa nechiremba wemwana wako kana mwana wako ane chero chinotevera:

• Marwadzo uye / kana kuzvimba, kazhinji mumawoko, makumbo, chifuva, musana, kana pelvis.

• Bundu (iro rinogona kunzwa rakapfava uye richidziya) mumaoko, makumbo, chifuva, kana chiuno.

• Fivha pasina chikonzero chinozivikanwa.

• Bhonzo rinotyoka pasina chikonzero chinozivikanwa.

Kuyedza kunoongorora bone uye zvinyoro nyoro zvinoshandiswa kuongorora uye danho Ewing sarcoma.

Maitiro anoita mifananidzo yemabhonzo uye zvinyoro nyoro nenzvimbo dziri padhuze anobatsira kuongorora Ewing sarcoma uye kuratidza kuti gomarara rapararira zvakadii. Maitiro anoshandiswa kutsvaga kana kenza maseru akapararira mukati nekukomberedza mapfupa uye zvinyoro nyoro kana kune zvimwe zvikamu zvemuviri zvinonzi staging.

Kuronga kurapwa, zvakakosha kuti uzive kana gomarara rapararira kune dzimwe nhengo dzemuviri. Kuyedza uye maitiro ekuona, kuongorora, uye danho Ewing sarcoma inowanzoitwa panguva imwe chete.

Iyi inotevera bvunzo uye maitiro anogona kushandiswa kuongorora kana danho Ewing sarcoma:

• Kuongorora kwepanyama uye nhoroondo: Kuongororwa kwemuviri kutarisa zviratidzo zvehutano, kusanganisira kuongorora zviratidzo zvehosha, zvakadai semapundu kana chero chinhu chinoratidzika sechisina kujairika. Nhoroondo yemaitiro ehutano hwemurwere uye kurwara kwakapfuura uye kurapwa kuchatorwawo.

• MRI (magnetic resonance imaging): Maitiro anoshandisa magineti, masaisai eredhiyo, uye komputa kugadzira yakateedzana mifananidzo yakajeka yenzvimbo dziri mukati memuviri, senzvimbo pakaumbwa bundu. Iyi nzira inonziwo nyukireya magnetic resonance imaging (NMRI).

Magnetic resonance imaging (MRI) yedumbu. Mwana akarara patafura inotsvedza ichipinda muMRI scanner, inotora mifananidzo yemukati memuviri. Iyo padhi padumbu remwana inobatsira kujekesa mifananidzo.

• CT scan (CAT scan): Maitiro anoita akateedzana emifananidzo yakajeka yenzvimbo dziri mukati memuviri, senzvimbo pakaumbwa bundu kana chipfuva, chakatorwa munzira dzakasiyana. Mifananidzo yacho inogadzirwa nekombuta yakabatana neiyo x-ray muchina. Dhayi inogona kuiswa jekiseni kana kumedzwa kubatsira nhengo kana zvinyama kuratidza zvakajeka. Iyi nzira inonziwo computed tomography, computerized tomography, kana komputa axial tomography.

Computed tomography (CT) scan yemudumbu. Mwana akarara patafura inotsvedza kuburikidza neCT scanner, iyo inotora mifananidzo ye x-ray yemukati medumbu.

• PET scan (positron emission tomography scan): Iyo nzira yekuwana yakaipa malonda maseru mumuviri. Chishoma che radioactive glucose (shuga) inoiswa mutsinga. Iyo PET scanner inotenderera yakatenderedza muviri uye inogadzira mufananidzo wepo glucose iri kushandiswa mumuviri. Malignant tumarara maseru anoratidza kupenya mumufananidzo nekuti anoshanda uye anotora glucose yakawanda kupfuura zvinoita maseru akajairwa. PET scan uye CT scan zvinowanzoitwa panguva imwe chete. Kana paine kenza, izvi zvinowedzera mukana wekuti iwanikwe.

Positron emission tomography (PET) scan. Mwana akarara patafura inotsvedza nepena scanner yePET. Musoro zororo uye tambo chena zvinobatsira mwana kunyepa zvakanyarara. Chishoma che radioactive glucose (shuga) inoiswa mutsinga yemwana, uye scanner inogadzira mufananidzo wekuti glucose irikushandiswa sei mumuviri. Cancer maseru anoratidza kupenya mumufananidzo nekuti anotora yakawanda glucose kupfuura zvakajairwa maseru.

• Bone scan: Maitiro ekutarisa kana paine nekukurumidza kupatsanura masero, senge kenza maseru, mupfupa. Chinhu chidiki kwazvo che radioactive chakabayiwa mutsinga uye chinofamba neropa. Iyo radioactive zvinhu inounganidza mumapfupa nekenza uye inoonekwa ne scanner.

Bone scan. Chinhu chidiki che radioactive chakabayiwa mutsinga yemwana uye chinofamba kuburikidza neropa. Iyo radioactive zvinhu inounganidza mumapfupa. Sezvo mwana akarara patafura inotsvedza pasi pe scanner, izvo zvine radioactive zvinoonekwa uye mifananidzo inogadzirwa pakombuta.

• Bone marrow aspiration uye biopsy: Kubviswa kwemongo wefupa uye chidimbu chefupa nekuisa tsono isina mhango muhudyu. Samples inobviswa kubva muchiuno chiuno. Nyanzvi yezvirwere anoona pfupa nemabhonzo pasi pe microscope kuti aone kana gomarara rapararira.

Bone marora chishuwo uye biopsy. Mushure mekunge nzvimbo diki yeganda yave nechiveve, tsono yemongo wemapfupa inoiswa mupfupa rehudyu remwana. Samples reropa, bhonzo, uye mwongo wemapfupa zvinobviswa kuti zviongororwe pasi pe microscope.

• X-ray: X-ray rudzi rwechigadziko chesimba chinogona kupfuura nemuviri uye kupinda mufirimu, ichigadzira mufananidzo wenzvimbo dziri mukati memuviri, senge chifuva kana nzvimbo pakaumbwa bundu.

• Yakazara kuverenga kweropa (CBC): Maitiro umo muyenzaniso weropa unodhonzwa nekuongororwa zvinotevera:

• Huwandu hwemasero matsvuku eropa, machena masero eropa, uye maplatelet.

• Huwandu hwehemoglobin (protein inotakura oxygen) mumasero matsvuku eropa.

• Chikamu chemuenzaniso weropa chakaumbwa nemasero matsvuku eropa.

• Ropa kemisitiri zvidzidzo: Maitiro umo muyedzo weropa unotariswa kuyera huwandu hwezvimwe zvinhu, senge lactate dehydrogenase (LDH), yakaburitswa muropa nenhengo uye nyama munyama. Chinhu chisina kujairika (chakakwirira kana chakaderera pane zvakajairwa) chiyero chechinhu chinogona kunge chiri chiratidzo chechirwere.

Biopsy inoitwa kuongorora Ewing sarcoma.

Masampuli enyama anobviswa panguva yebiopsy kuitira kuti agone kutariswa pasi pe microscope nachiremba kuti aone zviratidzo zvegomarara. Zvinobatsira kana bhaopsy ikaitwa panzvimbo imwe chete kunorapwa.

• Tsono biopsy: Kune tsono biopsy, tishu dzinobviswa uchishandisa tsono. Rudzi rwebiopsy runogona kuitwa kana zvichikwanisika kubvisa matomu sampu yakakura zvakakwana kuti ishandiswe kuyedzwa.

• Incisional biopsy: Kune incisional biopsy, sampuro yetissue inobviswa kuburikidza necision mukati meganda.

• Excisional biopsy: Kubviswa kwebundu rese kana nzvimbo yetishu isingatarise seyakajairika.

Nyanzvi (pathologist, radiation oncologist, uye chiremba) uyo acharapa murwere anowanzo shanda pamwechete kusarudza nzvimbo yakanaka yekuisa tsono kana biopsy incision. Kusarudzwa kwenzvimbo yebiopsy kwakakosha. Iyo biopsy saiti isina kusarudzwa mushe inogona kukonzeresa kuvhiya kwakakura kubvisa bundu kana nzvimbo hombe inorapwa ne radiation radiation.

Kana paine mukana wekuti gomarara rapararira kune ma lymph node ari padyo, rimwe kana anopfuura mamwe mahunze anogona kubviswa uye kuongororwa zviratidzo zvekenza.

Iyi bvunzo inotevera inogona kuitwa pane iyo turu iyo inobviswa:

• Kuongorora kweCytogenetic: Kuedzwa kwerabhoritari umo ma chromosomes emaseru mune svumbunuro yezvinyama zvinoverengerwa uye kuongororwa chero shanduko, dzakadai sekutyoka, kushaikwa, kugadziriswazve, kana mamwe ma chromosomes. Shanduko mune mamwe ma chromosomes inogona kunge iri chiratidzo checancer. Kuongorora kweCytogenetic kunoshandiswa kubatsira kuongorora cancer, kuronga kurapwa, kana kuona kuti kurapa kuri kushanda sei.

• Immunohistochemistry: Kuongororwa kwerabhoritari inoshandisa masoja ekudzivirira mamwe maantigen (mamaki) mune imwe sampuro yetishu yemurwere. Masoja ekudzivirira chirwere anowanzo sunganidzwa ne enzyme kana dhayi ye fluorescent. Mushure mekunge maantibodies akasunga kune yakasarudzika antigen mune yeiyo sampuli, iyo enzyme kana dhayi inoitwa, uye iyo antigen inogona kuzoonekwa pasi pe microscope. Rudzi urwu rweyedzo runoshandiswa kubatsira kuongorora gomarara uye kubatsira kutaurira imwe mhando yekenza kubva kune imwe mhando yegomarara.

• Kuyerera cytometry: Kuedzwa kwerabhoritari kunoyera huwandu hwamasero mune imwe sampuro, muzana yemasero mhenyu mune imwe sampuro, uye mamwe maitiro emaseru, senge saizi, chimiro, uye kuvepo kwethumba (kana zvimwe) mamaki pane sero pamusoro. Masero kubva pamuenzaniso weropa remurwere, mwongo wemapfupa, kana zvimwe zvinyama zvakasvibiswa nedhayi re fluorescent, rakaiswa mune mvura, uye ndokuzopfuura rimwe panguva kuburikidza nemwenje wechiedza. Mhedzisiro yekubvunzurudza inoenderana nekuti maseru aive akasvibiswa neiyo fluorescent dhayi anoita sei padanda rechiedza.

Zvimwe zvinhu zvinokanganisa kufungidzira (mukana wekupora).

Izvo zvinhu zvinokanganisa kufungidzira (mukana wekupora) zvakasiyana musati uye mushure mekurapwa.

Pamberi pekurapwa kupihwa, kufungidzira kunoenderana ne:

• Kunyangwe iro bundu rapararira kune lymph node kana zvikamu zviri kure zvemuviri.

• Iko mumuviri bundu rakatanga.

• Kunyangwe bundu rakaumbika mupfupa kana munyama nyoro.

• Iyo yakakura sei bundu kana bundu rikaonekwa.

• Kunyangwe bundu racho rakonzera chero mapfupa akatyoka.

• Kunyangwe iyo LDH mwero muropa iri yakakwira kupfuura zvakajairwa.

• Kunyangwe bundu racho riine rimwe jeni rinoshanduka.

• Kunyangwe murwere ari mudiki pane makore gumi nemashanu.

• Bonde remurwere.

• Kunyangwe murwere akarapwa gomarara rakasiyana.

• Kunyangwe bundu racho richangobva kuongororwa kana kuti radzokazve (dzoka).

Mushure mekupihwa kurapwa, kufungidzira kunokanganiswa ne:

• Kunyangwe bundu racho rakabviswa zvachose nekuvhiyiwa.

• Kunyangwe bundu rakapindura chemotherapy kana radiation radiation.

Kana kenza ikadzokazve mushure mekutanga kurapwa, kufungidzira kunoenderana ne:

• Kunyangwe kenza yakadzoka makore anopfuura maviri mushure mekutanga kurapwa.

• Kunyangwe kenza yakadzoka payakatanga kuumba kana mune dzimwe nhengo dzemuviri.

Matanho eEwing Sarcoma

PFUNGWA DZINOKOSHA

• Mhedzisiro yekuongorora uye staging bvunzo inoshandiswa kutsvaga kana kenza maseru yapararira.

• Ewing sarcoma inotsanangurwa seinowanikwa munharaunda, metastatic, kana kudzokorora.

• Yemunharaunda Ewing sarcoma

• Metastatic Ewing sarcoma

• Kudzokorora Ewing sarcoma

• Pane nzira nhatu dzinopararira negomarara mumuviri.

• Gomarara rinogona kutapukira kubva kwarakatanga kuenda kune dzimwe nhengo dzemuviri.

Mhedzisiro yekuongorora uye staging bvunzo inoshandiswa kutsvaga kana kenza maseru yapararira.

Maitiro akashandiswa kutsvaga kana gomarara rapararira kubva kwarakatangira kune dzimwe nhengo dzemuviri inonzi staging Iko hakuna standard standard staging system yeEwing sarcoma. Mhedzisiro yemiyedzo uye maitiro anoitwa kuongorora uye danho Ewing sarcoma anoshandiswa kutsanangura mamota seakawanikwa enzvimbo kana metastatic.

Ewing sarcoma inotsanangurwa seinowanikwa munharaunda, metastatic, kana kudzokorora.

Ewing sarcoma inotsanangurwa seinowanikwa munharaunda, metastatic, kana kudzokorora.

Yemunharaunda Ewing sarcoma

Gomarara rinowanikwa mupfupa kana zvinyoro nyoro kwarakatangira uye rinogona kunge rakapararira kumatishu ari pedyo, kusanganisira ma lymph node ari pedyo.

Metastatic Ewing sarcoma

Gomarara rakapararira kubva mubhonzo kana munyama munyoro kwaakatanga kuenda kune dzimwe nhengo dzemuviri. MuEwing bundu repfupa, gomarara rinowanzo pararira kumapapu, mamwe mapfupa, uye mwongo wefupa.

Kudzokorora Ewing sarcoma

Gomarara rakadzoka (radzoka) mushure mekurapwa. Gomarara rinogona kudzoka mubhonzo kana munyama munyoro kwaakatangira kana mune imwe nhengo yemuviri.

Pane nzira nhatu dzinopararira negomarara mumuviri.

Kenza inogona kupararira kuburikidza nematinji, iyo lymph system, uye neropa:

• Tishu. Kenza inopararira kubva kwayakatanga nekukura ichipinda munzvimbo dziri pedyo.

• Lymph maitiro. Kenza inopararira kubva kwayakatanga nekupinda muiyo lymph system. Kenza inofamba nemumidziyo yema lymph ichienda kune dzimwe nhengo dzemuviri.

• Ropa. Kenza inopararira kubva payakatanga nekupinda muropa. Kenza inofamba nemidzi yeropa ichienda kune dzimwe nhengo dzemuviri.

Gomarara rinogona kutapukira kubva kwarakatanga kuenda kune dzimwe nhengo dzemuviri.

Kana kenza ikapararira kune chimwe chikamu chemuviri, inonzi metastasis. Cancer maseru anotsemuka kubva kwaakatanga (iro bundu rekutanga) uye achifamba kuburikidza neye lymph system kana ropa.

• Lymph maitiro. Gomarara rinopinda mu "lymph system", rinofamba nemumidziyo ye "lymph", uye rinogadzira bundu (metastatic tumor) mune chimwe chikamu chemuviri.

• Ropa. Kenza inopinda muropa, inofamba nemutsinga dzeropa, yoita bundu (metastatic tumor) mune chimwe chikamu chemuviri.

Iyo metastatic bundu irwo rudzi rwecancer seyakanyanya bundu. Semuenzaniso, kana Ewing sarcoma ichipararira kuenda kumapapu, masero ekenza mumapapu ari Ewing sarcoma maseru. Hosha iyi ndeye metastatic Ewing sarcoma, kwete kenza yemapapu.

Kurapa Sarudzo Kuongorora

PFUNGWA DZINOKOSHA

• Kune mhando dzakasiyana dzekurapa kwevana vane Ewing sarcoma.

• Vana vane Ewing sarcoma vanofanirwa kurapwa kwavo kuchirongwa nechikwata chevanoona nezvehutano vari nyanzvi pakurapa kenza muvana.

• Kurapa kweEwing sarcoma kunogona kukonzera mhedzisiro.

• Mhando ina dzekurapa kwakajairika dzinoshandiswa:

• Chemotherapy

• Radiation kurapa

• Kuvhiya

• Yakakwira-dose chemotherapy ine stem cell kununura

• Mhando nyowani dzekurapa dziri kuyedzwa mumakiriniki ekuedzwa.

• Targeted kurapwa

• Immunotherapy

• Varwere vangangoda kufunga nezve kutora chikamu mukutora kiriniki.

• Varwere vanogona kupinda mumakiriniki miedzo vasati, panguva, kana mushure mekutanga kwavo kenza kurapwa.

• Yekutevera-bvunzo inogona kudikanwa.

Kune mhando dzakasiyana dzekurapa kwevana vane Ewing sarcoma.

Mhando dzakasiyana dzekurapa dzinowanikwa kune vana vane Ewing sarcoma. Mamwe marapirwo akajairwa (iko kurapwa kwazvino kwashandiswa), uye kumwe kuedzwa mumakiriniki ekuedzwa A kurapwa kiriniki kuyedzwa chidzidzo chekutsvaga chakaitirwa kubatsira kuvandudza marapirwo azvino kana kuwana ruzivo marapirwo matsva evarwere vane gomarara. Kana kiriniki miedzo ikaratidza kuti kurapwa kutsva kuri nani pane kwese kurapwa, kurapwa kutsva kunogona kuve kwakajairwa kurapwa.

Nekuti kenza muvana nevechiri kuyaruka isingawanzoitika, kutora chikamu mukutongwa kwekiriniki kunofanirwa kutariswa. Mimwe miedzo yekiriniki yakavhurwa chete kune varwere vasina kutanga kurapwa.

Vana vane Ewing sarcoma vanofanirwa kurapwa kwavo kuchirongwa nechikwata chevanoona nezvehutano vari nyanzvi pakurapa kenza muvana.

Kurapa kunozoonekwa nachiremba wevana oncologist, chiremba ane hunyanzvi hwekurapa vana vane gomarara. Vanachiremba oncologist vanoshanda nevamwe vatapi vezvehutano vari nyanzvi pakurapa vana vane Ewing sarcoma uye vanoziva mune dzimwe nzvimbo dzemishonga. Izvi zvinogona kusanganisira vanachiremba vanotevera:

• Chiremba wevana.

• Kuvhiya oncologist kana orthopedic oncologist.

• Radiation oncologist.

• Mukoti wechiremba nyanzvi.

• Wezvemagariro.

• Rehabilitation nyanzvi.

• Nyanzvi yezvepfungwa.

Kurapa kweEwing sarcoma kunogona kukonzera mhedzisiro.

Kuti uwane ruzivo nezve mhedzisiro inotanga panguva yekurapa kenza, ona yedu Side Mhedzisiro peji.

Zvimwe zvinokonzeresa kubva pakurapwa nekenza zvinotanga mushure mekurapwa uye kuenderera kwemwedzi kana makore zvinonzi kunonoka kuitika Mhedzisiro mhedzisiro yekurapwa nekenza inogona kusanganisira zvinotevera:

• Zvinetso zvepanyama.

• Shanduko mumanzwiro, manzwiro, kufunga, kudzidza, kana ndangariro.

• Gomarara repiri (mhando nyowani dzekenza). Varwere vanorapwa kuEwing sarcoma vane njodzi yakawedzera yeacute myeloid leukemia uye myelodysplastic syndrome. Kune zvakare njodzi yakawedzera yesarcoma munzvimbo inorapwa ne radiation radiation.

Mimwe mhedzisiro mhedzisiro inogona kurapwa kana kudzorwa. Izvo zvakakosha kuti utaure navanachiremba vemwana wako nezve mhedzisiro yekurapwa nekenza kunogona kuve pamwana wako. (Ona pfupiso ye paMagumo Ekurapa kweKenza Yevacheche kuti uwane rumwe ruzivo.)

Mhando ina dzekurapa kwakajairika dzinoshandiswa:

Chemotherapy

Chemotherapy mushonga wekenza unoshandisa mishonga kumisa kukura kwemasero ekenza, kungave nekuuraya maseru kana nekuamisa iwo kubva pakupatsanuka. Kana chemotherapy ikatorwa nemuromo kana kujowa mutsinga kana mhasuru, mishonga inopinda muropa uye inogona kusvika masero emukenza mumuviri wese (systemic chemotherapy). Kana chemotherapy ikaiswa yakanangana necerebrospinal fluid, nhengo, kana dumbu remuviri senge dumbu, mishonga inonyanya kukanganisa maseru ekenza munzvimbo idzodzo (chemotherapy yedunhu). Kusanganiswa chemotherapy kurapwa kunoshandisa anopfuura imwe anticancer mushonga.

Systemic mubatanidzwa chemotherapy chikamu chekurapa kune vese varwere vane Ewing tumors. Kazhinji kurapwa kwekutanga kunopihwa uye kunotora kwemwedzi mitanhatu kusvika gumi nemiviri. Chemotherapy inowanzo kupihwa kudzikisa bundu usati wavhiyiwa kana kurapwa nemwaranzi uye kuuraya chero tumarara maseru anogona kunge akapararira kune dzimwe nhengo dzemuviri.

Ona Zvinodhaka Zvinotenderwa zveSoft Tissue Sarcoma kuti uwane rumwe ruzivo.

Radiation kurapa

Radiation kurapa kurapwa kenza iyo inoshandisa yakakwira-simba x-rays kana mamwe marudzi e radiation kuuraya cancer maseru kana kuachengeta iwo kuti asakure. Kune mhando mbiri dze radiation radiation:

• External radiation therapy inoshandisa muchina uri kunze kwemuviri kutumira radiation kune kenza.

• Yemukati radiation kurapwa kunoshandisa radioactive chinhu chakavharirwa mune tsono, mhodzi, waya, kana makateti anoiswa akananga mukati kana padyo nekenza.

External radiation therapy inoshandiswa kurapa Ewing sarcoma.

Radiation kurapwa kunoshandiswa apo bundu risingakwanise kubviswa nekuvhiyiwa kana kana kuvhiyiwa kubvisa bundu kuchizokanganisa zvakakosha mabasa emuviri kana nzira inotaridzika mwana. Inogona kushandiswa kuita kuti bundu rive diki uye kudzikisa huwandu hweturu iyo inoda kubviswa panguva yekuvhiyiwa. Inogona zvakare kushandiswa kurapa chero bundu rinosara mushure mekuvhiyiwa uye mamota akapararira kune dzimwe nhengo dzemuviri.

Kuvhiya

Kuvhiya kunowanzoitwa kubvisa kenza inosara mushure memakemikari kana radiation radiation. Kana zvichibvira, bundu rose rinobviswa nekuvhiya. Nyama uye pfupa zvinobviswa zvinogona kutsiviwa nechomumvura, icho chinoshandisa zvinyama uye pfupa zvinotorwa kubva kune chimwe chikamu chemuviri wemurwere kana mupi. Dzimwe nguva kuiswa, kwakadai sebhonzo rekugadzira, kunoshandiswa.

Mushure mekunge chiremba abvisa kenza yese inoonekwa panguva yekuvhiyiwa, vamwe varwere vanogona kupihwa chemotherapy kana radiation radiation mushure mekuvhiyiwa kuuraya chero gomarara maseru akasara. Mushonga wakapihwa mushure mekuvhiyiwa, kudzikisa njodzi yekuti gomarara richadzoka, inonzi adjuvant therapy.

Yakakwira-dose chemotherapy ine stem cell kununura

Yakakwira madosi ekemotherapy anopiwa kuuraya cancer maseru. Masero ane hutano, kusanganisira masero anogadzira ropa, anoparadzwa nekenza kurapwa. Stem cell transplant kurapwa kwekutsiva maseru anogadzira ropa. Masero emashizha (masero eropa asina kusimba) anobviswa muropa kana mwongo wemapfupa emurwere kana mupi uye anoomeswa nechando. Mushure mekunge murwere apedza chemotherapy, maseru akachengetwa anonyungudutswa uye ndokudzoserwa kumurwere kuburikidza nekumukiswa. Aya akadzikiswa maseru emadzinde anokura kuita (uye kudzoreredza) masero eropa emuviri. Chemotherapy ine stem cell kununura inoshandiswa kurapa munzvimbo nenzvimbo Ewing sarcoma.

Mhando nyowani dzekurapa dziri kuyedzwa mumakiriniki ekuedzwa.

Ichi chidimbu chikamu chinotsanangura kurapwa kuri kuongororwa mumakiriniki ekuedzwa. Zvinogona kusataura nezveese marapirwo matsva ari kuongororwa. Ruzivo nezve kiriniki miedzo inowanikwa kubva kuNCI webhusaiti.

Targeted kurapwa

Targeted kurapwa ndiko kurapwa kunoshandisa zvinodhaka kana zvimwe zvinhu kupindira nemaitiro ayo maseru ekenza anoda kukura uye kukura. Mhando dzezvinorapwa zvakanangwa zvinoshandiswa kurapa kenza dzisiri dzehudiki dzevacheche dzinosanganisira zvinotevera:

• Monoclonal antibody therapy: Monoclonal antibodies anogadzirwa murabhoritari kubva kune imwechete mhando yemasoja ekudzivirira maseru. Aya ma antibodies anokwanisa kuona zvinhu pane cancer cancer kana zvakajairika zvinhu zvinogona kubatsira gomarara maseru kukura. Masoja ekudzivirira chirwere anonamira pazvinhu uye anouraya maseru egomarara, anovharira kukura kwawo, kana kuti aachengetedze kubva pakupararira. Monoclonal antibodies inopihwa nekumisirwa. Inogona kushandiswa yoga kana kutakura zvinodhaka, chepfu, kana zvinhu zvine radioactive zvakanangana nemasero ekenza. Ganitumab irikudzidziswa yekurapa metastatic Ewing sarcoma.

• Kinase inhibitor therapy: Kinase inhibitors mishonga inovhara puroteni inodiwa kuti maseru ekenza apatsanuke. Ivo vari kuongororwa kuti vabate zvinowanzoitika Ewing sarcoma.

• NEDD8-inoshanda enzyme (NAE) inhibitor kurapa: NAE inhibitors mishonga inonamira kuAE uye inomisa maseru ekenza kubva pakupatsanuka. Pevonedistat iri kuongororwa mukurapa kweanowanzoitwa Ewing sarcoma.

Immunotherapy

Immunotherapy kurapwa kunoshandisa immune system yemurwere kurwisa gomarara. Zvinhu zvinogadzirwa nemuviri kana kugadzirwa murabhoritari zvinoshandiswa kusimudzira, kunongedza, kana kudzorera kudzivirira kwemuviri kurwisa kenza. Rudzi rwekurapa kenza urwu rwunonziwo biotherapy kana biologic therapy.

• Immune checkpoint inhibitor therapy: Immune checkpoint inhibitors inovhara mamwe mapuroteni anogadzirwa nemaseru ezvirwere zvemuviri, akadai seT maseru, uye mamwe maseru ekenza. Aya mapuroteni anobatsira kuchengetedza mhinduro dzemumuviri uye anogona kuchengetedza masero eT kubva pakuuraya cancer maseru. Kana mapuroteni aya akavharika, "mabhureki" pane immune system anosunungurwa uye T maseru anokwanisa kuuraya cancer maseru zvirinani. Nivolumab uye ipilimumab ndiwo marudzi e immune checkpoint inhibitors ari kudzidziswa kuti arape zvekare Ewing sarcoma.

• Chimeric antigen receptor (CAR) T-cell kurapa: CAR T-cell kurapa imhando yemununotherapy iyo inoshandura yemurwere T masero (rudzi rwema immune system sero) saka ivo vanozorwisa mamwe mapuroteni ari pamusoro pekenza maseru. T maseru anotorwa kubva kumurwere uye akakosha maakagamuchirwa anowedzerwa kumusoro kwawo murabhoritari. Masero akachinjwa anonzi chimeric antigen receptor (CAR) T masero. Masero eCAR T anokurirwa murabhoritari uye anopiwa murwere nekumukisa. Masero eCAR T anowanda muropa remurwere uye anorwisa maseru egomarara. CAR T-cell kurapa kuri kuongororwa mukurapa kwekudzokorora Ewing sarcoma.

MOTO T-cell kurapa. Rudzi rwekurapa umo masero eT emurwere (rudzi rwemuviri wemasero emuviri) anochinjwa murabhoritari kuitira kuti vasunge masero egomarara vovauraya. Ropa kubva mutsinga iri muruoko rwemurwere inoyerera nepombi kusvika kumuchina weapheresis (usina kuratidzwa), unobvisa masero eropa machena, kusanganisira maT seli, uye wotumira iro rasara rose ropa kumurwere. Zvino, iyo geni yeakagamuchirwa yakakosha inonzi chimeric antigen receptor (CAR) inoiswa mukati meT maseru murabhoritari. Mamirioni emaCAR T maseru anokurirwa murabhoritari uye ndokuzopihwa kumurwere nekumukisa. Masero eCAR T anokwanisa kusunga kune antigen pane masero ekenza uye nekuvauraya.

Varwere vangangoda kufunga nezve kutora chikamu mukutora kiriniki.

Kune vamwe varwere, kutora chikamu mumuedzo wekiriniki inogona kunge iri sarudzo yekurapa yakanyanya kunaka. Kliniki miedzo chikamu chekenza tsvagiridzo. Zvemakiriniki miedzo inoitwa kuti uone kana marapirwo matsva egomarara akachengeteka uye achishanda kana zvirinani pane akajairwa kurapwa.

Mazhinji emazuva ano marapirwo akajairwa ekenza akavakirwa pamavambo emakiriniki ekuedzwa. Varwere vanotora chikamu mukuyedzwa kwekiriniki vanogona kuwana kurapwa kwakaringana kana kuve pakati pevekutanga kurapwa kutsva.

Varwere vanotora chikamu mumiedzo yekiriniki zvakare vanobatsira kugadzirisa marapirwo achaitwa kenza mune ramangwana. Kunyangwe kana miedzo yemakiriniki isinga tangire kumarapirwo matsva anoshanda, anowanzo pindura mibvunzo yakakosha uye anobatsira kufambisira mberi kutsvagurudza.

Varwere vanogona kupinda mumakiriniki miedzo vasati, panguva, kana mushure mekutanga kwavo kenza kurapwa.

Mimwe miedzo yekiriniki inosanganisira chete varwere vasati vagamuchira kurapwa. Mimwe miedzo yekuedza kurapwa kwevarwere vane kenza haina kuve nani. Kune mamwezve emakiriniki miedzo inoedza nzira nyowani dzekumisa cancer kubva kudzokororazve (kudzoka) kana kudzikisira mhedzisiro yemakenza kurapwa.

Kuedzwa kwemakiriniki kuri kuitika munzvimbo zhinji dzenyika. Ruzivo nezve kiriniki miedzo inotsigirwa neNCI inogona kuwanikwa paNCI yekiriniki miedzo yekutsvaga peji rewebhu. Kliniki miedzo inotsigirwa nemamwe masangano inogona kuwanikwa pane yeClinicalTrials.gov webhusaiti.

Yekutevera-bvunzo inogona kudikanwa.

Mimwe miedzo yakaitwa kuongorora gomarara kana kutsvaga danho rekenza inogona kudzokororwa. Dzimwe bvunzo dzinodzokororwa kuitira kuti vaone kuti kurapa kuri kushanda sei. Sarudzo nezvekuti uenderere mberi, shandura, kana kumisa kurapwa kunogona kunge kuchibva pamhedzisiro yeiyi bvunzo.

Mimwe bvunzo ichaenderera ichiitwa nguva nenguva mushure mekunge kurapwa kwapera. Mhedzisiro yeiyi bvunzo inogona kuratidza kana mamiriro emwana wako achinja kana kana gomarara radzoka (dzoka). Iyi bvunzo dzimwe nguva inonzi yekuteedzera-bvunzo kana kuongorora-kumusoro.

Kurapa Sarudzo dzeEwing Sarcoma

Muchikamu chino

• Yemunharaunda Ewing Sarcoma

• Metastatic Ewing Sarcoma

• Kudzokorora Ewing Sarcoma

Kuti uwane ruzivo nezve marapirwo akanyorwa pazasi, ona iyo Chikamu Sarudzo Yekutarisa Chikamu.

Yemunharaunda Ewing Sarcoma

Kurapa kwakajairwa kwenzvimbo yeEwing sarcoma inosanganisira

• Chemotherapy.

• Kuvhiya uye / kana radiation radiation.

• Yakakwira-dose chemotherapy ine stem cell kununura.

Shandisa yedu kiriniki yekuyedza kutsvaga kutsvaga NCI-yakatsigirwa kenza kiriniki miedzo iri kugamuchira varwere. Unogona kutsvaga miedzo zvichibva parudzi rwecancer, zera remurwere, uye iko kunoitwa miyedzo. Ruzhinji ruzivo nezve zvekuedzwa zvekiriniki zvakare zviripo.

Metastatic Ewing Sarcoma

Maitiro akarapa ekurapa metastatic Ewing sarcoma anosanganisira:

• Chemotherapy.

• Kuvhiya.

• Radiation kurapa.

Shandisa yedu kiriniki yekuyedza kutsvaga kutsvaga NCI-yakatsigirwa kenza kiriniki miedzo iri kugamuchira varwere. Unogona kutsvaga miedzo zvichibva parudzi rwecancer, zera remurwere, uye iko kunoitwa miyedzo. Ruzhinji ruzivo nezve zvekuedzwa zvekiriniki zvakare zviripo.

Kudzokorora Ewing Sarcoma

Iko hakuna kwakajairika kurapwa kweinowanzoitika Ewing sarcoma asi nzira dzekurapa dzinogona kusanganisira zvinotevera:

• Kusanganiswa chemotherapy.

• Radiation kurapa kumabhonzo mapundu, senge palliative kurapa kubvisa zviratidzo uye kuvandudza hupenyu hwehupenyu.

• Radiation Therap iyo inogona kuteverwa nekuvhiya kubvisa mamota ayo akapararira kumapapu.

• Yakakwira-dose chemotherapy ine stem cell kununura.

Sarudzo dzekurapa dziri kudzidziswa kweanowanzoitika Ewing sarcoma anosanganisira anotevera:

• Kutarisa sampuro yebundu remurwere kune mamwe magene anochinja. Rudzi rwekurapa kwakanangwa kuchapihwa kumurwere kunoenderana nerudzi rwechinjo yemajini.

• Targeted Therapy ine tyrosine kinase inhibitor (cabozantinib).

• Immunotherapy ine immune checkpoint inhibitor (nivolumab kana ipilimumab).

• Chimeric antigen receptor (CAR) T-cell kurapa.

• Targeted Therapy ine NEDD8-inoshanda enzyme inhibitor (pevonedistat) uye chemotherapy.

• Kuongororwa kwekiriniki yemhando nyowani yekurapa kwakanangwa.

Shandisa yedu kiriniki yekuyedza kutsvaga kutsvaga NCI-yakatsigirwa kenza kiriniki miedzo iri kugamuchira varwere. Unogona kutsvaga miedzo zvichibva parudzi rwecancer, zera remurwere, uye iko kunoitwa miyedzo. Ruzhinji ruzivo nezve zvekuedzwa zvekiriniki zvakare zviripo.

Kuti Udzidze Zvakawanda Nezve Ewing Sarcoma

Kuti uwane rumwe ruzivo kubva kuNational Cancer Institute nezve Ewing sarcoma, ona zvinotevera:

• Bone Cancer Kumba Peji

• Computed Tomography (CT) Scans uye Cancer

• Targeted Cancer Therapies

• Kenza Bone

Kuti uwane rumwe ruzivo rwegomarara rehucheche uye zvimwe zvecancer zviwanikwa, ona zvinotevera:

• Nezve Kenza

• Cancers Yevacheche

• Kurapa Kutsvaga Kwevana Cancer Buda Disclaimer

• Mahedhi Ekupedzisira Ekurapwa kweKenza Yevacheche

• Vechidiki uye Vechidiki Vakuru vane Cancer

• Vana vane Cancer: Nhungamiro Yevabereki

• Kenza muVana neVachiri kuyaruka

• Stage

• Kurarama neCancer

• Mibvunzo Yekubvunza Wako Chiremba nezveCancer

• Kune Vakapona uye Vanotarisira