About-cancer/treatment/clinical-trials/thymoma-thymic-carcinoma
Clinical Miedzo yekurapa Thymoma uye Thymic Carcinoma
Miedzo 1-12 ye12
Carboplatin uye Paclitaxel ine kana isina Ramucirumab Mukurapa Varwere vane Nharaunda Yepamberi, Yazvino, kana Metastatic Thymic Cancer Iyo Isingakwanise Kubviswa nekuvhiya.
Ichi chisinganzwisisike chikamu chechipiri cheyedzo yekuongorora kuti zvakanaka sei carboplatin uye paclitaxel ine kana isina ramucirumab inoshanda pakurapa varwere vane kenza ye thymic yakapararira kumatishu ari pedyo kana ma lymph node (emunharaunda epamberi), yadzoka (yazvino), yapararira kune dzimwe nzvimbo mu muviri (metastatic) kana haigone kubviswa nekuvhiyiwa. Zvinodhaka zvinoshandiswa mukemotherapy, senge carboplatin uye paclitaxel, zvinoshanda nenzira dzakasiyana kumisa kukura kwemarara maseru, kungave nekuuraya maseru, nekuamisa iwo kubva pakupatsanuka, kana nekuamisa iwo pakupararira. Monoclonal antibodies, senge ramucirumab, inogona kukanganisa kugona kwesimba remarara kukura nekupararira. Hazvisati zvazivikanwa kana kupa carboplatin uye paclitaxel ine kana isina ramucirumab kuchashanda zvirinani pakurapa varwere vane cancer yekenza.
Nzvimbo: 254 nzvimbo
Chidzidzo cheXmAb®20717 mune Zvidzidzo zvine Sarudzo Dzakasimba Dzakasimba Tumarara
Ichi chidimbu 1, yakawanda dosi, ichikwira dhosi yekuwedzera kudzidza kutsanangura MTD / RD uye regimen yeXmAb20717, kurondedzera kuchengetedzeka uye kushivirira, kuongorora PK uye immunogenicity, uye kutanga kuongorora anti-bundu chiitiko cheXmAb20717 mune zvidzidzo zvakasarudzwa Mberi yakasimba mamota.
Nzvimbo: 15 nzvimbo
Nivolumab naVorolanib Mukurapa Varwere Neiyo Isiri-Diki Cell Lung Cancer uye Refractory Thoracic Tumors.
Ichi chikamu I / II kuyedza kunoongorora iyo mhedzisiro uye yakanyanya dhosi ye vorolanib painopihwa pamwe chete nivolumab pakurapa varwere vane isiri-diki kenza yemapapu kenza uye thoracic tumors dzisiri kupindura kurapwa (dzinopesana). Immunotherapy ine monoclonal antibodies, senge nivolumab, inogona kubatsira immune system kurwisa gomarara, uye inogona kukanganisa kugona kwesimba remarara kukura nekupararira. Vorolanib inogona kumisa kukura kwemarara maseru nekuvhara mamwe maenzymes anodiwa kuti sero kukura. Kupa nivolumab uye vorolanib kunogona kushanda zvirinani pakurapa varwere vane isina-diki maseru kenza yemapapu uye tumarara tunduru.
Nzvimbo: 7 nzvimbo
Kudzidza kweSO-C101 uye SO-C101 mukubatanidzwa nePembro muVakuru Varwere vane Advanced / Metastatic Solid Tumors.
A multicenter open-label chikamu 1 / 1b kudzidza kuongorora kuchengetedzeka uye kwekutanga kushanda kweSO-C101 se monotherapy uye pamwe chete ne pembrolizumab mune varwere vane yakasarudzwa yepamusoro / metastatic solid tumors.
Nzvimbo: 2 nzvimbo
Kukurumidza Kuongorora uye Kupindura Kuongorora kweMubatanidzwa Anti-Neoplastic Agents muRare Tumors (RARE CANCER) Trial: RARE 1 Nilotinib naPaclitaxel
Mhemberero: Vanhu vane kenza isingawanzo kuwanikwa kazhinji vane nzira shoma dzekurapa. Iyo biology yeasingawanzo kenza haina kunyatsonzwisiswa. Vanotsvaga vanoda kutsvaga zvirinani kurapwa kweizvi cancer. Ivo vanoda kuyedza 2 mishonga iyo, yakatorwa zvakasiyana, yakabatsira vanhu vane isina kujairika cancer. Vanoda kuona kana mishonga iyi pamwe chete ichigona kuita kuti kanzuru dzisingawanzo dzike kana kumira kukura. Chinangwa: Kudzidza kana nilotinib uye paclitaxel zvichabatsira vanhu vane kenza isingawanzo. Kukodzera: Vanhu vane makore gumi nemasere zvichikwira vane kenza isingawanzo, yepamusoro iyo yakafambira mberi mushure mekugamuchira kurapwa kwakaringana, kana iko kusina kurapwa kunoshanda. Dhizaini: Vatori vechikamu vanozoongororwa neyakaitika nhoroondo yezvokurapa uye bvunzo dzepanyama. Vanozoongororwa ropa uye weti. Vachave nemuedzo wepamuviri kana zvichidikanwa. Vachave neiyo electrocardiogram yekutarisa moyo yavo. Vachave nemifananidzo yekufungidzira kuyera mamota avo. Vatori vechikamu vanodzokorora bvunzo dzekuongorora panguva yechidzidzo. Vatori vechikamu vanogamuchira nilotinib uye paclitaxel. Iyo mishonga inopihwa mumazuva makumi maviri nemasere. Nilotinib kapisi inotorwa nemuromo kaviri pazuva. Paclitaxel ichapihwa mukati mehutachiona netambo yekumusoro kana wepakati mutsetse kamwe pavhiki kwemavhiki matatu ekutanga eimwe kutenderera. Vatori vechikamu vanochengeta diary yemishonga. Vanozoteedzera pavanotora mishonga yekudzidza uye chero mhedzisiro yavanogona kuve nayo. Vatori vechikamu vanogona kunge vaine sarudzo bundu biopsies. Vatori vechikamu vanogona kuramba vari pachidzidzo kudzamara chirwere chavo chanyanyisa kukura kana kuti vaine zvinokanganisika zvisingabvumike. Vatori vechikamu vanozoita yekutevera-kufona ingangoita mazuva makumi matatu mushure mekutora muyero wekupedzisira wemishonga yekudzidza. Vatori vechikamu vanogamuchira nilotinib uye paclitaxel. Iyo mishonga inopihwa mumazuva makumi maviri nemasere. Nilotinib kapisi inotorwa nemuromo kaviri pazuva. Paclitaxel ichapihwa mukati mehutachiona netambo yekumusoro kana wepakati mutsetse kamwe pavhiki kwemavhiki matatu ekutanga eimwe kutenderera. Vatori vechikamu vanochengeta diary yemishonga. Vanozoteedzera pavanotora mishonga yekudzidza uye chero mhedzisiro yavanogona kuve nayo. Vatori vechikamu vanogona kunge vaine sarudzo bundu biopsies. Vatori vechikamu vanogona kuramba vari pachidzidzo kudzamara chirwere chavo chanyanyisa kukura kana kuti vaine zvinokanganisika zvisingabvumike. Vatori vechikamu vanozoita yekutevera-kufona ingangoita mazuva makumi matatu mushure mekutora muyero wekupedzisira wemishonga yekudzidza. Vatori vechikamu vanogamuchira nilotinib uye paclitaxel. Iyo mishonga inopihwa mumazuva makumi maviri nemasere. Nilotinib kapisi inotorwa nemuromo kaviri pazuva. Paclitaxel ichapihwa mukati mehutachiona netambo yekumusoro kana wepakati mutsetse kamwe pavhiki kwemavhiki matatu ekutanga eimwe kutenderera. Vatori vechikamu vanochengeta diary yemishonga. Vanozoteedzera pavanotora mishonga yekudzidza uye chero mhedzisiro yavanogona kuve nayo. Vatori vechikamu vanogona kunge vaine sarudzo bundu biopsies. Vatori vechikamu vanogona kuramba vari pachidzidzo kudzamara chirwere chavo chanyanyisa kukura kana kuti vaine zvinokanganisika zvisingabvumike. Vatori vechikamu vanozoita yekutevera-kufona ingangoita mazuva makumi matatu mushure mekutora muyero wekupedzisira wemishonga yekudzidza. Paclitaxel ichapihwa mukati mehutachiona netambo yekumusoro kana wepakati mutsetse kamwe pavhiki kwemavhiki matatu ekutanga eimwe kutenderera. Vatori vechikamu vanochengeta diary yemishonga. Vanozoteedzera pavanotora mishonga yekudzidza uye chero mhedzisiro yavanogona kuve nayo. Vatori vechikamu vanogona kunge vaine sarudzo bundu biopsies. Vatori vechikamu vanogona kuramba vari pachidzidzo kudzamara chirwere chavo chanyanyisa kukura kana kuti vaine zvinokanganisika zvisingabvumike. Vatori vechikamu vanozoita yekutevera-kufona ingangoita mazuva makumi matatu mushure mekutora muyero wekupedzisira wemishonga yekudzidza. Paclitaxel ichapihwa mukati mehutachiona netambo yekumusoro kana wepakati mutsetse kamwe pavhiki kwemavhiki matatu ekutanga eimwe kutenderera. Vatori vechikamu vanochengeta diary yemishonga. Vanozoteedzera pavanotora mishonga yekudzidza uye chero mhedzisiro yavanogona kuve nayo. Vatori vechikamu vanogona kunge vaine sarudzo bundu biopsies. Vatori vechikamu vanogona kuramba vari pachidzidzo kudzamara chirwere chavo chanyanyisa kukura kana kuti vaine zvinokanganisika zvisingabvumike. Vatori vechikamu vanozoita yekutevera-kufona ingangoita mazuva makumi matatu mushure mekutora muyero wekupedzisira wemishonga yekudzidza.
Nzvimbo: National Institutes of Health Clinical Center, Bethesda, Maryland
Pembrolizumab uye Sunitinib Malate Mukurapa Vatori vechikamu neRefractory Metastatic kana Isingaonekwe Thymic Cancer
Iyi chikamu II kuyedzwa kunoongorora mashandiro anoita pembrolizumab uye sunitinib malate pakurapa vatori vechikamu nekenza ye thymic yakapararira kune dzimwe nzvimbo mumuviri kana isingakwanise kubviswa nekuvhiyiwa uye isingapindure kurapwa. Monoclonal antibodies, senge pembrolizumab, inogona kukanganisa kugona kwesimba remarara kukura nekupararira. Sunitinib malate inogona kumisa kukura kwemarara maseru nekuvharira mamwe ma enzyme anodiwa kuti sero rikure. Kupa pembrolizumab uye sunitinib malate kunogona kushanda zvirinani pakurapa kenza ye thymic.
Nzvimbo: Ohio State University Yakakwana Cancer Center, Columbus, Ohio
Pembrolizumab Mukurapa Vatori vechikamu vane Unresectable Thymoma kana Thymic Cancer
Ichi chikamu ini muyedzo unoongorora mativi mhedzisiro uye yakanakisa dosi yepembrolizumab mukurapa vatori vechikamu vane thymoma kana kenza ye thymic isingakwanise kubviswa nekuvhiya. Immunotherapy ine monoclonal antibodies, senge pembrolizumab, inogona kubatsira immune immune kurwisa gomarara, uye inogona kukanganisa kugona kwesimba remarara kukura nekupararira.
Nzvimbo: MD Anderson Cancer Center, Houston, Texas
Selinexor Mukurapa Vatori vechikamu neAdvanced Thymic Epithelial Tumor
Ichi chikamu chechipiri cheyedzo yekuongorora mashandiro anoita selinexor mukurapa vatori vechikamu vane thymic epithelial bundu rakapararira kune dzimwe nzvimbo mumuviri. Selinexor inogona kumisa kukura kwemarara maseru nekuvhara mamwe mapuroteni anodiwa kuti sero rikure.
Nzvimbo: 2 nzvimbo
Bintrafusp Alfa (M7824) mune Zvidzidzo zvine Thymoma uye Thymic Carcinoma
Mhemberero: Thymoma uye thymic carcinoma zvirwere zve thymus. Platinum-based chemotherapy ndiyo yakajairwa kurapwa kwezvirwere izvi. Asi mune dzakawanda zviitiko, chirwere chinodzoka mushure mekurapwa. Vatsvagiri vanoda kuona kana mushonga mutsva ungabatsira. Chinangwa: Kuona kana bintrafusp alfa (M7824) iri mushonga unoshanda we thymoma uye thymic carcinoma. Kukodzera: Vanhu vane makore gumi nemasere zvichikwira vane thymoma kana kenza ye thymic uye chirwere chavo chakadzoka kana kufambira mberi mushure mekurapwa nechero platinamu ine chemotherapy chirongwa chekurapa, kana vakaramba kurapwa kwakajairika Dhizaini: Vatori vechikamu vanovhenekwa pasi peyakasiyana protocol. Yadzo yekurapa, mushonga, uye nhoroondo yekurapa ichaongororwa. Vachave nebundu biopsy kana vasina sampuro. Vatori vechikamu vanozowana mushonga wekudzidza kamwe chete pavhiki mbiri sekupinza mukati. Kune izvi, diki repurasitiki chubhu inoiswa mune ruoko tsinga. Munguva yechidzidzo, vatori vechikamu vanozoita zvinotevera: Kuongorora kweMushonga Kuongorora kwemuviri Ongororo yezviratidzo zvavo uye kugona kwavo kuita zviitwa zvavo zvakajairwa Ropa uye weti miedzo Gumbo musuru scan (uchishandisa MRI) Tumor kuongorora (uchishandisa MRI kana CT) Mwoyo nemapapu bvunzo Utachiona gland test Ganda kuongorora. Vatori vechikamu vanogona kunge vane bundu biopsies. Mamwe eropa ravo uye bhaopsy sampuli anozo shandiswa pakuongorora majini. Vatori vechikamu vanogona kutora mushonga wekudzidza kudzamara chirwere chavo chanyanya kana vasingakwanise kutsungirira kurapwa. Vatori vechikamu vanozove neanotevera-ekushanya mavhiki maviri ne6 mushure mekumisa kurapwa. Ipapo ivo vanozove neyakareba-yekutevera-ekushanya kwega kwega kwemwedzi mitatu. Izvi zvinogona kusanganisira mifananidzo yekufungidzira. Kushanya kunogona kuitwa nefoni, nematanho (kana zvichidikanwa) achiitwa kuhofisi yavo yechiremba. Nzvimbo:
Abexinostat uye Pembrolizumab Mukurapa Varwere vane MSI-Yakakwira Yemunharaunda Yakawedzera kana Metastatic Solid Tumors.
Ichi chikamu I muyedzo unoongorora yakanakisa dhosi uye mhedzisiro mhedzisiro yeabexinostat uye kuti inoshanda zvakadii kupihwa pamwe chete ne pembrolizumab mukurapa varwere vane microsatellite kusagadzikana (MSI) mamota akasimba akapararira kumaturu ari pedyo kana ma lymph node (enzvimbo yepamusoro) kana dzimwe nzvimbo mumuviri (metastatic). Abexinostat inogona kumisa kukura kwemarara maseru nekuvharira mamwe ma enzymes anodiwa kuti sero kukura. Immunotherapy ine monoclonal antibodies, senge pembrolizumab, inogona kubatsira immune immune kurwisa gomarara, uye inogona kukanganisa kugona kwesimba remarara kukura nekupararira. Kupa abexinostat uye pembrolizumab kunogona kushanda zvirinani pakurapa varwere vane mamota akasimba.
Nzvimbo: UCSF Medical Center-Gomo reZion, San Francisco, California
Oral TrkA Inhibitor VMD-928 yekurapa kweVakuru Vakuru Solid Tumors kana Lymphoma
Iyi multicenter, yakavhurika-chitaridzi, Phase 1 kudzidza yemumuromo inotungamirwa VMD-928 mune vakuru zvidzidzo zvine advanced solid mamota kana lymphoma akafambira mberi kana asingateereri kune aripo marapirwo uye ayo asina akajairwa kana aripo ekurapa kurapa aripo
Nzvimbo: Guta reTariro Yakakwana Cancer Center, Duarte, California
Chidzidzo chePilot Yekuongorora Kudzivirirwa uye Kiriniki Chiitiko cheAvelumab (MSB0010718C) muThymoma uye Thymic Carcinoma Mushure mekufambira mberi kwePlatinum-Yakavakirwa Chemotherapy.
Mhemberero: Thymoma uye thymic carcinoma ndiwo kanzira dzinobva mu thymus gland. Platinum-based chemotherapy kurapwa kwakaringana kwavari. Asi zvisingawanzoitika, chirwere chinodzoka uye vanhu vanoda kurapwa kwakawanda kuti gomarara rirege kukura. Mushonga Avelumab unogona kubatsira immune system kurwisa cancer. Chinangwa: Kuedza kana avelumab yakachengeteka uye ichinyatsoshivirirwa, uye inoshanda pakurapa yakadzokororwa kana yekudzora thymoma uye thymic carcinoma. Kukodzera: Vanhu vane makore gumi nemasere zvichikwira vane thymoma kana thymic carcinoma iyo yadzoka kana kufambira mberi mushure meplatinum ine chemotherapy Dhizaini: Vatori vechikamu vanovhenekwa ne: - Ropa, weti, uye bvunzo dzemwoyo - Scan: Vanorara mumushini unotora mifananidzo ye muviri. - Kuongorora kwepanyama - Chiitiko chekurapa - Biopsy: tsono inobvisa chidimbu chebundu. Samples inogona kubva kunzira yapfuura, kunyangwe zvichidikanwa kuti uite bhaopsy nyowani. Vatori vechikamu vanozove nekurapwa mu2-vhiki kutenderera. Vachaenderera mberi kusvikira miganho yacho isingashivirike kana chirwere chavo chichiwedzera. Kushanya panguva dzinotevera nguva kunodiwa pane imwe protocol. Varwere vanopindura kurapwa kana vane kugadzikana kwakasimba mushure memwedzi gumi nembiri yekurapwa vanogona kuita dosi de-escalation regimen kuti varambe vachirapa. - Ose mavhiki maviri: Vatori vechikamu vanowana avelumab nekupfekedzwa mutsinga (IV). Vachawana diphenhydramine (benadryl) uye acetaminophen (tylenol) nemuromo kana IV vasati vagamuchira avelumab kudzikisira mikana yekuvandudza mhinduro kune avelumab. Vachave neropa, weti, uye nemoyo bvunzo nguva nenguva. - MaCircule 4 ne7, uyezve mavhiki matanhatu ega ega: Scans ichaitwa kutsvaga kutsvaira kana kukura kwethumba. - Kutenderera 4: Vatori vechikamu vachapihwa mukana wekupinda bhiopsy. - 2-4 mavhiki mushure mekumisa kurapwa: Ropa, weti, uye nemoyo bvunzo zvichaitwa. Vatori vechikamu vanogona kuongororwa. - masvondo gumi mushure mekumira kurapwa: Ropa, weti, uye nemoyo bvunzo. - Inenge mwedzi mitanhatu mushure mekumira kurapwa, uyezve pamwedzi mitatu yega yega: Vatori vechikamu vanozove nematanho uye vanogona kubvumira kuyedzwa kwemajini paropa ravo uye masuru sampuli.
Nzvimbo: National Institutes of Health Clinical Center, Bethesda, Maryland
Bvumira mhinduro auto-Refresher