About-cancer / kurapwa / kiriniki-miedzo / chirwere / kaposi-sarcoma / kurapwa
Kurapa Kliniki Miedzo yeKaposi Sarcoma
Kliniki miedzo ndeyekutsvagisa zvidzidzo zvinosanganisira vanhu. Iwo makiriniki ekuedzwa pane ino rondedzero ndeyeKaposi sarcoma kurapwa. Yese miedzo pane irondedzero inotsigirwa neNCI.
Ruzivo rweNCI rwekutanga nezve zviedzo zvemakiriniki zvinotsanangura mhando nezvikamu zvemiyedzo uye maitirwo azvo. Kliniki miedzo inotarisa nzira nyowani dzekudzivirira, kuona, kana kubata chirwere. Iwe ungangoda kufunga nezve kutora chikamu mukutora kiriniki. Taura nachiremba wako kuti akubatsire kusarudza kana imwe yakakunakira iwe.
Miedzo 1-7 ye7
Nivolumab neIpilimumab Mukurapa Varwere vaneHIV Yakabatana Yakadzokororwa kana Refractory Classical Hodgkin Lymphoma kana Solid Tumors Iyo Ine Metastatic kana Haigone Kubviswa neKuvhiya
Ichi chikamu I muyedzo unoongorora mhedzisiro uye yakanakisa dosi yeiyo nivolumab painopihwa neipilimumab mukurapa varwere vane hutachiona hwehutachiona hwehutachiona (HIV) inosanganisirwa yechinyakare Hodgkin lymphoma yakadzoka mushure menguva yekuvandudza kana kusapindura kurapwa, kana mamota akasimba ayo yakapararira kune dzimwe nzvimbo mumuviri kana kuti haigone kubviswa nekuvhiyiwa. Immunotherapy ine monoclonal antibodies, senge ipilimumab uye nivolumab, inogona kubatsira immune system kurwisa gomarara, uye inogona kukanganisa kugona kwesimba remarara kukura nekupararira. Ipilimumab chirwere chinorwisa mamorekuru anonzi cytotoxic T-lymphocyte antigen 4 (CTLA-4). CTLA-4 inodzora chikamu chemuviri wako nekudzivirira iyo pasi. Nivolumab rudzi rweantibody iyo yakanangana neyakagadzirirwa munhu kufa kwesero 1 (PD-1), puroteni ine chekuita nekuparadzwa kwema immune immune. Kupa ipilimumab ne nivolumab kunogona kushanda zvirinani pakurapa varwere vane hutachiwana hweHIV hwakabatana hwechinyakare Hodgkin lymphoma kana mamota akasimba achienzaniswa neipilimumab ine nivolumab chete.
Nzvimbo: 28 nzvimbo
Nelfinavir Mesylate Mukurapa Varwere neKaposi Sarcoma
Ichi chirongwa chekuchaira chikamu chechipiri chekuyedza mashandiro anoita nelfinavir mesylate mukurapa varwere veKaposi sarcoma. Nelfinavir mesylate inogona kumisa kukura kwemarara maseru nekuvharira mamwe ma enzyme anodiwa kukura kwesero.
Nzvimbo: 11 nzvimbo
sEphB4-HSA Mukurapa Varwere neKaposi Sarcoma
Ichi chikamu II chekuyedza chinodzokorora recombinant EphB4-HSA fusion protein (sEphB4-HSA) pakurapa varwere vane Kaposi sarcoma. Recombinant EphB4-HSA fusion protein inogona kutadzisa kukura kwemidziyo yeropa inopa ropa kukenza, uye inogona zvakare kudzivirira cancer maseru kubva mukukura.
Nzvimbo: 10 nzvimbo
Pembrolizumab Mukurapa Varwere vane HIV uye Vakadzokazve, Refractory, kana Kuparadzirwa Malignant Neoplasms
Ichi chikamu I chekuyedza chinoongorora mhedzisiro ye pembrolizumab mukurapa varwere vane hutachiona hwehutachiona hwehutachiona (HIV) uye maronda akaipa anodzoka (adzokazve), haapindure pakurapwa (kukanganisa), kana kugovera pamusoro penzvimbo huru mumuviri (yakaparadzirwa). Monoclonal antibodies, senge pembrolizumab, inogona kuvhara bundu kana kenza kukura munzira dzakasiyana nekutarisa mamwe maseru. Inogona zvakare kubatsira immune system kuuraya cancer maseru.
Nzvimbo: 10 nzvimbo
Intra-lesional Nivolumab Mukurapa Varwere neCutaneous Kaposi Sarcoma
Ichi chikamu ini muyedzo unoongorora mhedzisiro ye nivolumab jekiseni rakananga muchironda uye kuona kuti rinoshanda zvakadii pakurapa varwere vane cutaneous Kaposi sarcoma. Immunotherapy ine monoclonal antibodies, senge nivolumab, inogona kubatsira immune system kurwisa gomarara, uye inogona kukanganisa kugona kwesimba remarara kukura nekupararira.
Nzvimbo: 2 nzvimbo
Nhoroondo yeKSHV Inopisa Cytokine Syndrome (KICS)
Nechekumashure: - KSHV yekuzvimba cytokine syndrome (KICS) hosha ichangobva kuzivikanwa inokonzerwa neKaposi sarcoma-inosanganiswa herpesvirus (KSHV). Utachiona uhu hunogona kukonzera cancer. Vanhu vane KICS vanogona kuva nezviratidzo zvakakomba. Zvinosanganisira kupisa muviri, kuonda, uye kuyerera kwemvura mumakumbo kana mudumbu. Vanhu vane KICS vanogona zvakare kuve panjodzi yekuwana mamwe kanzira inosangana neKSHV. Aya makenza anosanganisira Kaposi sarcoma uye lymphoma. Nekuti KICS hosha ichangobva kuzivikanwa, ruzivo rwakawanda runodiwa kuti chirwere ichi chinoshanda sei uye chii chingaitwe kuchirapa. Zvinangwa: - Kuunganidza ruzivo nezvekurapa kubva kuvanhu vane KSHV yekuzvimba cytokine syndrome. Kukodzera: - Vanhu vane makore angangoita gumi nemasere ekuberekwa vane Kaposi sarcoma herpes hutachiona uye zviratidzo zvakafanana neizvo zvinokonzerwa neKICS. Dhizaini: - Vatori vechikamu vanozogara vachishanyirwa pakudzidza. Iyo purogiramu ichave yakatarwa nevanoongorora vanotsvagurudza. - Vatori vechikamu vanozopa yakazara nhoroondo yezvokurapa uye vanozara zvizere bvunzo yemuviri. Ropa uye weti sampuli zvichaunganidzwa futi. - Vanhu vane KICS inoda kurapwa vanogona kuwana mishonga mitsva yekuyedza. Aya marapirwo anogona kusanganisira antiviral zvinodhaka uye chemotherapy madhiragi, zvichienderana nemhando yechirwere. - Vatori vechikamu vanozove nezvidzidzo zvekufungidzira, senge chest x-rays uye computed tomography scans, yekudzidza mamota. - Bone mwongo uye lymph node biopsies zvinogona kuitwa kutora matomu sampuli ekudzidza. - Vatori vechikamu vane Kaposi sarcoma vanozotorwa mifananidzo yezvironda zvavo. - Vanhu vane KICS inoda kurapwa vanogona kuwana mishonga mitsva yekuyedza. Aya marapirwo anogona kusanganisira antiviral zvinodhaka uye chemotherapy madhiragi, zvichienderana nemhando yechirwere. - Vatori vechikamu vanozove nezvidzidzo zvekufungidzira, senge chest x-rays uye computed tomography scans, yekudzidza mamota. - Bone mwongo uye lymph node biopsies zvinogona kuitwa kutora matomu sampuli ekudzidza. - Vatori vechikamu vane Kaposi sarcoma vanozotorwa mifananidzo yezvironda zvavo. - Vanhu vane KICS inoda kurapwa vanogona kuwana mishonga mitsva yekuyedza. Aya marapirwo anogona kusanganisira antiviral zvinodhaka uye chemotherapy madhiragi, zvichienderana nemhando yechirwere. - Vatori vechikamu vanozove nezvidzidzo zvekufungidzira, senge chest x-rays uye computed tomography scans, yekudzidza mamota. - Bone mwongo uye lymph node biopsies zvinogona kuitwa kutora matomu sampuli ekudzidza. - Vatori vechikamu vane Kaposi sarcoma vanozotorwa mifananidzo yezvironda zvavo. - Bone mwongo uye lymph node biopsies zvinogona kuitwa kutora matomu sampuli ekudzidza. - Vatori vechikamu vane Kaposi sarcoma vanozotorwa mifananidzo yezvironda zvavo. - Bone mwongo uye lymph node biopsies zvinogona kuitwa kutora matomu sampuli ekudzidza. - Vatori vechikamu vane Kaposi sarcoma vanozotorwa mifananidzo yezvironda zvavo.
Nzvimbo: 2 nzvimbo
Pomalidomide muKusanganiswa neLiposomal Doxorubicin muVanhu Vane Zvigadziriso kana Refractory Kaposi Sarcoma
Background: Kaposi sarcoma (KS) kenza inowanzoonekwa kune vanhu vane HIV. Inokonzera maronda. Izvi zvinowanzova paganda asi dzimwe nguva mune ma lymph node, mapapu, uye nemudumbu. Vatsvagiri vanofunga kuti kusanganiswa kwemishonga kunogona kubatsira kubata KS. Chinangwa: Kuyedza mubatanidzwa wemishonga inorwisa kenza pomalidomide (CC-4047) uye liposomal doxorubicin (Doxil) mune vanhu vane KS. Eligibility: Vanhu vane makore gumi nemasere zvichikwira neKS Dhizaini: Vatori vechikamu vanovhenekwa ne: Chiitiko chekurapa Mibvunzo yekuongorora Panyama Ropa, weti, uye kuyedza kwemoyo Chest X-ray Biopsy: Muenzaniso mudiki wetissue unotorwa kubva kuKS lesion. Possible CT scan Possible bvunzo yemapapu kana yemudumbu turakiti ine endoscope: Chishandiso chinoshanduka chinoongorora mukati memuviri. Vatori vechikamu vanotora iwo madhiragi mu4-vhiki kutenderera. Ivo vachatora Doxil kuburikidza ne IV paZuva 1 remutambo wega wega. Vachatora mapiritsi eCC-4047 nemuromo zuva rega rega kwemavhiki matatu ekutanga emutambo wega wega. Vatori vechikamu vanozove nekushanyirwa kwakawanda: Usati watanga kurapwa Kutanga rimwe nerimwe kutenderera Zuva regumi neshanu eekutanga maviri macircuit Kushanya kunosanganisira kudzokororwa kwekuyedzwa kuongorora uye: Ropa rakawanda rinodhonza Mifananidzo yezvironda Vatori vechikamu vanochengeta diary yezvinodhaka. Vatori vechikamu vanotora aspirin kana mimwe mishonga yekudzivirira kuwanda kweropa. Vatori vechikamu vane hutachiwana hweHIV vachange vaine mishonga yekubatanidza antiretroviral. Vamwe vatori vechikamu vanozove nePET scan. Vatori vechikamu vanoenderera mberi nekurapwa sekureba sekuzvitsungirira kwavo uye yavo KS inovandudzika. Mushure mekurapwa, vanozove neanoverengeka ekutevera-ekushanya kweanosvika makore mashanu ... Usati watanga kurapwa Kuti utange kutenderera kwega kwega Zuva 15 rekutanga maviri macircuit Kushanya kunosanganisira kudzokororwa kwekuyedzwa uye: Ropa rakawanda rinodhonza Mifananidzo yezvironda Vatori vechikamu vanochengeta diary remishonga. Vatori vechikamu vanotora aspirin kana mimwe mishonga yekudzivirira kuwanda kweropa. Vatori vechikamu vane hutachiwana hweHIV vachange vaine mishonga yekubatanidza antiretroviral. Vamwe vatori vechikamu vanozove nePET scan. Vatori vechikamu vanoenderera mberi nekurapwa sekureba sekuzvitsungirira kwavo uye yavo KS inovandudzika. Mushure mekurapwa, vanozove neanoverengeka ekutevera-ekushanya kweanosvika makore mashanu ... Usati watanga kurapwa Kuti utange kutenderera kwega kwega Zuva 15 rekutanga maviri macircuit Kushanya kunosanganisira kudzokororwa kwekuyedzwa uye: Ropa rakawanda rinodhonza Mifananidzo yezvironda Vatori vechikamu vanochengeta diary remishonga. Vatori vechikamu vanotora aspirin kana mimwe mishonga yekudzivirira kuwanda kweropa. Vatori vechikamu vane hutachiwana hweHIV vachange vaine mishonga yekubatanidza antiretroviral. Vamwe vatori vechikamu vanozove nePET scan. Vatori vechikamu vanoenderera mberi nekurapwa sekureba sekuzvitsungirira kwavo uye yavo KS inovandudzika. Mushure mekurapwa, vanozove neanoverengeka ekutevera-ekushanya kweanosvika makore mashanu ... Vatori vechikamu vane hutachiwana hweHIV vachange vaine mishonga yekubatanidza antiretroviral. Vamwe vatori vechikamu vanozove nePET scan. Vatori vechikamu vanoenderera mberi nekurapwa sekureba sekuzvitsungirira kwavo uye yavo KS inovandudzika. Mushure mekurapwa, vanozove neanoverengeka ekutevera-ekushanya kweanosvika makore mashanu ... Vatori vechikamu vane hutachiwana hweHIV vachange vaine mishonga yekubatanidza antiretroviral. Vamwe vatori vechikamu vanozove nePET scan. Vatori vechikamu vanoenderera mberi nekurapwa sekureba sekuzvitsungirira kwavo uye yavo KS inovandudzika. Mushure mekurapwa, vanozove neanoverengeka ekutevera-ekushanya kweanosvika makore mashanu ...
Nzvimbo: National Institutes of Health Clinical Center, Bethesda, Maryland
