About-cancer / kurapwa / kiriniki-miedzo / chirwere / extragonadal-germ-cell-tumarara / kurapwa
Kurapa Kliniki Miedzo yeExtragonadal Germ Cell Tumor
Kliniki miedzo ndeyekutsvagisa zvidzidzo zvinosanganisira vanhu. Iwo makiriniki ekuedzwa pane ino runyorwa ndeye extragonadal germ cell tumarara kurapwa. Yese miedzo pane irondedzero inotsigirwa neNCI.
Ruzivo rweNCI rwekutanga nezve zviedzo zvemakiriniki zvinotsanangura mhando nezvikamu zvemiyedzo uye maitirwo azvo. Kliniki miedzo inotarisa nzira nyowani dzekudzivirira, kuona, kana kubata chirwere. Iwe ungangoda kufunga nezve kutora chikamu mukutora kiriniki. Taura nachiremba wako kuti akubatsire kusarudza kana imwe yakakunakira iwe.
Miedzo 1-7 ye7
Kushanda Kwekutarisa, Bleomycin, Carboplatin, Etoposide, kana Cisplatin Mukurapa Kwevana uye Vakuru Varwere neGerm Cell Tumors.
Ichi chikamu chechitatu cheyedzo inoongorora mashandiro anoita kuongororwa, bleomycin, carboplatin, etoposide, kana cisplatin inoshanda pakurapa kwevana uye kwevakuru varwere vane hutachiona hwemaseru. Kushanda kwekutarisa kunogona kubatsira vanachiremba kuongorora zvidzidzo zvine njodzi yakadzika yemajemusi maseru mamota mushure mekunge bundu ravo rabviswa. Zvinodhaka zvinoshandiswa mukemotherapy, senge bleomycin, carboplatin, etoposide, uye cisplatin, zvinoshanda nenzira dzakasiyana kumisa kukura kwemarara maseru, kungave nekuuraya iwo maseru, nekuamisa iwo kubva pakupatsanuka, kana nekuamisa iwo kubva pakupararira.
Nzvimbo: 435 nzvimbo
Inokurumidza kana Yakajairwa BEP Chemotherapy Mukurapa Varwere vane Zvepakati kana Varombo-Njodzi Metastatic Germ Cell Tumors.
Ichi chisinganzwisisike chikamu chechitatu cheyedzo yekuongorora kuti yakadii kukurumidza chirongwa chebluomycin sulphate, etoposide phosphate, uye cisplatin (BEP) chemotherapy inoshanda ichienzaniswa neyakajairwa chirongwa cheBEP chemotherapy pakurapa varwere vane chepakati kana varombo-vane hutachiona hutachiona hutachiona hwakapararira kune vamwe nzvimbo mumuviri (metastatic). Zvinodhaka zvinoshandiswa mukemotherapy, senge bleomycin sulphate, etoposide phosphate, uye cisplatin, zvinoshanda nenzira dzakasiyana kumisa kukura kwemarara maseru, kungave nekuuraya iwo maseru, nekuamisa iwo kubva pakupatsanuka, kana nekuamisa iwo kubva pakupararira. Kupa BEP chemotherapy pane inokurumidza, kana "kukurumidza" chirongwa kunogona kushanda zvirinani nemhedzisiro mhedzisiro pakurapa varwere vane wepakati kana varombo-njodzi metastatic germ cell tumors zvichienzaniswa neyakajairwa purogiramu.
Nzvimbo: 126 nzvimbo
Standard-Dose Kusanganisa Chemotherapy kana Yakakwira-Dosi Kusanganisa Chemotherapy uye Stem Cell Kuisirwa Mukurapa Varwere vane Vakadzokororwa kana Vanokanganisa maGerm Cell Tumors.
Ichi chisinganzwisisike chikamu chechitatu cheyedzo yekuongorora kuti yakadii-dosi inosanganiswa chemotherapy inoshanda kana ichienzaniswa neepamusoro-dhizaini inosanganisa chemotherapy uye stem cell yekuisa pakurapa varwere vane hutachiona maseru mamota ayo adzoka mushure menguva yekuvandudza kana vasina kupindura kurapwa. Zvinodhaka zvinoshandiswa mukemotherapy, senge paclitaxel, ifosfamide, cisplatin, carboplatin, uye etoposide, zvinoshanda munzira dzakasiyana kumisa kukura kwemarara maseru, kungave nekuuraya maseru, nekuamisa iwo kubva pakupatsanuka, kana nekuamisa iwo kubva pakupararira. Kupa chemotherapy pamberi pesemin cell transplant inomisa kukura kwemasero ekenza nekuamisa iwo kubva pakuaparadzanisa kana kuvauraya Kupa zvinhu zvinokurudzira koloni, senge filgrastim kana pegfilgrastim, uye mamwe machemotherapy madhiragi, inobatsira masero emidzi kutama kubva mumongo wemapfupa kuenda muropa kuti agone kuunganidzwa nekuchengetwa. Chemotherapy inozopihwa kugadzirira mwongo wepfupa weiyo stem cell yekuisa. Masero emadzinde anozodzorerwa kumurwere kutsiva masero anogadzira ropa ayo akaparadzwa nekemotherapy. Izvo hazvisati zvazivikanwa kana yakakwira-dhizaini inosanganisa chemotherapy uye stem cell yekuisa inoshanda zvakanyanya kupfuura yakajairwa-dhizaini inosanganisa chemotherapy pakurapa varwere vane refractory kana vadzokerezve utachiona hwemaseru.
Nzvimbo: 54 nzvimbo
Durvalumab uye Tremelimumab Mukurapa Varwere vane Vakadzokazve kana Refractory Germ Cell Tumors
Ichi chikamu chechipiri cheyedzo yekuongorora mashandiro anoita durvalumab uye tremelimumab mukurapa varwere vane hutachiona hwemaseru hutachiona hwakadzoka mushure menguva yekuvandudza kana kusapindura kurapwa. Immunotherapy ine monoclonal antibodies, senge durvalumab uye tremelimumab, inogona kubatsira immune system kurwisa gomarara, uye inogona kukanganisa kugona kwesimba remarara kukura nekupararira.
Nzvimbo: 7 nzvimbo
Autologous Peripheral Ropa Stem Cell Kuisa kweGerm Cell Tumors
Kurapa sarudzo dzevanodzokazve kana kusagadzikana hutachiona hwemajeri (GCT) varwere ishoma. Yakakwira-dose chemotherapy ine stem cell kununura (autologous stem cell kuisirwa), painopihwa zvakateedzana, yakaratidza kuti subset yevarwere inogona kurapwa. Iyo yakakwana yepamusoro-dhi chemotherapy regimen, zvisinei, haina kuzivikanwa. Mune ino muyedzo, isu tinoshandisa tandem autologous transplants ine isiri-muchinjika isingagadzirike mamiriro ekugadzirisa marapirwo ekurapa varwere vane vakadzokerazve / vanokanganisa maGCT.
Nzvimbo: Yunivhesiti yeMinnesota / Masonic Cancer Center, Minneapolis, Minnesota
Melphalan, Carboplatin, Mannitol, uye Sodium Thiosulfate Mukurapa Varwere neRecurrent kana Progressive CNS Embryonal kana Germ Cell Tumors.
Iyi chikamu I / II kuyedza inoongorora iyo mhedzisiro uye yakanyanya dhizaini yemelphalan painopihwa pamwechete ne carboplatin, mannitol, uye sodium thiosulfate, uye kuona kuti vanoshanda zvakadii pakurapa varwere vane inodzokororwa kana inofambira mberi central nervous system (CNS) embryonal kana utachiona. mamota emasero. Zvinodhaka zvinoshandiswa mukemotherapy, senge melphalan uye carboplatin, zvinoshanda munzira dzakasiyana kumisa kukura kwemarara maseru, kungave nekuuraya maseru, nekuamisa iwo kubva pakupatsanuka, kana nekuamisa iwo pakupararira. Osmotic ropa-huropi chipingamupinyi kukanganiswa (BBBD) inoshandisa mannitol kuvhura tsinga dzeropa dzakatenderedza uropi uye kubvumira kenza-kuuraya zvinhu kutakurwa zvakananga kuuropi. Sodium thiosulfate inogona kubatsira kudzikisira kana kudzivirira kurasikirwa kwekunzwa uye huturu muvarwere vari kurapwa chemotherapy ne carboplatin uye BBBD.
Nzvimbo: 2 nzvimbo
Adjuvant Tumor Lysate Vaccine uye Iscomatrix Iine kana Pasina Metronomic Oral Cyclophosphamide uye Celecoxib mune Varwere Vane Malignancies Anosanganisira Mapapu, Esophagus, Pleura, kana Mediastinum.
Background: Mumakore achangopfuura, cancer-testis (CT) maantigen (CTA), kunyanya iwo akanyorwa nemajini pane X chromosome (CT-X magene), akabuda sezvakanaka zvinangwa zvecancer immunotherapy. Ipo huipi hweakasiyana histologies hunoratidza dzakasiyana siyana dzeCTA, mhinduro dzekuzvidzivirira kumaprotein aya anoita kunge asinganzwisisike muvarwere vegomarara, pamwe nekuda kwenzvimbo yepasi, isina kujairika antigen expression, pamwe nema immunosuppressive anomiririra T maseru aripo mukati mematunhu nzvimbo uye systemic kutenderera kwevanhu ava. . Zvinonzwisisika, kubaiwa kwevarwere vegomarara vane mamota maseru anoratidza akakwira maCTAs akabatana nehurongwa hunopedza kana kudzivisa T maseru anodzora anounza hutachiona hwakakura kune aya maantigen. Kuti uongorore nyaya iyi, varwere vane gomarara repamoyo uye esophageal cancer, pleural mesotheliomas, thoracic sarcomas, thymic neoplasms uye mediastinal germ cell tumors, pamwe nesarcomas, melanomas, germ cell tumors, kana epithelial malignancies metastatic kumapapu, pleura kana mediastinum isina humbowo hwechirwere (NED) kana hushoma hunosara chirwere (MRD) zvichitevera standard multidisciplinary therapy ichave iri jekiseni neH1299 tumor cell lysates neIscomatrix adjuvant. Majekiseni anozopihwa pamwe kana pasina metronomic yemuromo cyclophosphamide (50 mg PO BID x 7d q 14d), uye celecoxib (400 mg PO BID). Serologic inopindura kune akasiyana siyana anodzokorodza maCTA pamwe neyemunologic mhinduro kune autologous bundu kana epigenetically yakagadziridzwa autologous EBVtransformed lymphocyte ichaongororwa pamberi uye mushure memwedzi mitanhatu yekudzivirira nguva. Zvinangwa Zvekutanga: 1. Kuongorora kuwanda kwema immunologic mhinduro kune maCTA mune varwere vane thoracic malignancies anotevera majekiseni neH1299 cell lysate / Iscomatrix (TM) majekiseni ega pakuenzanisa nevarwere vane thoracic malignancies anotevera majekiseni neH1299 cell lysate / Iscomatrix vaccines pamwe ne metronomic cyclophosphamide uye celecoxibib . Zvinangwa zveSekondari: 1. Kuongorora kana remuromo metronomic cyclophosphamide uye celecoxib kurapa kunoderedza huwandu uye muzana weT anotonga maseru uye kunoderedza mashandiro emaseru aya kune varwere vane thoracic malignancies vari panjodzi yekudzokazve. 2. Kuongorora kana H1299 cell lysate / Iscomatrix (TM) nhomba inowedzera immunologic mhinduro kune autologous bundu kana epigenetically yakagadziridzwa autologous EBV-yakashandurwa lymphocyte (B maseru). Kukodzera - Varwere vane histologically kana cytologically yakaratidza diki sero kana isiri-diki kenza yemapapu kenza (SCLC; NSCLC), esophageal cancer (EsC), malignant pleural mesothelioma (MPM), thymic kana mediastinal germ cell tumors, thoracic sarcomas, kana melanomas, sarcomas, kana epithelial malignancies metastatic kumapapu, pleura kana mediastinum vasina humbowo hwekiriniki hwechirwere chinoshanda (NED), kana chirwere chakasara chinosara (MRD) chisingawanikwe nyore nyore neasina-invasive biopsy kana resection / radiation inotevera yakajairwa kurapa kwakapedzwa mukati memavhiki 26 apfuura . - Varwere vanofanirwa kunge vaine makore gumi nemasere kana kudarika neECOG yekuita chinzvimbo che0 2. - Varwere vanofanirwa kuve nemongo wakakwana wemapfupa, itsvo, chiropa, mapapu uye nemoyo basa. - Varwere vanogona kunge vasiri pane systemic immunosuppressive mishonga panguva yekubaiwa majekiseni. Dhizaini: - Kutevera kupora kubva pakuvhiya, chemotherapy, kana chemo / XRT, varwere vane NED kana MRD vanozobaiwa jekiseni kuburikidza IM jekiseni neH1299 cell lysates uye Iscomatrix (TM) inowedzera mwedzi pamwedzi kwemwedzi mitanhatu. - Mishonga yekudzivirira ichaiswa pamwe kana isina metronomic yemuromo cyclophosphamide uye celecoxib. - Systemicityity uye immunologic mhinduro kurapi inonyorwa. Pre uye post yekudzivirira serologic uye maseru anopindirana mhinduro kune yakajairwa mapaneru eCT maantigen pamwe nema autologous bundu maseru (kana aripo) uye EBV-yakashandurwa lymphocyte ichaongororwa pamberi uye mushure mekudzivirira. - Numeri / muzana uye mashandiro eT anodzora maseru muropa remukati anozoongororwa kare, panguva, uye mushure mekubaiwa majekiseni. - Varwere vachateverwa kukiriniki neyakajairika staging scans kusvika chirwere chadzoka.
Nzvimbo: National Institutes of Health Clinical Center, Bethesda, Maryland
