Types/myeloproliferative/patient/mds-mpd-treatment-pdq

Myelodysplastic / Myeloproliferative Neoplasms Togafitiga (®) –Patient Version

Faʻamatalaga lautele e uiga i Myelodysplastic / Myeloproliferative Neoplasms

MANATU AUTU

• Myelodysplastic / myeloproliferative neoplasms o se vaega o faʻamaʻi o le ponaivi ponaivi faia tele papaʻe sela toto.

• Myelodysplastic / myeloproliferative neoplasms ei ai foliga o myelodysplastic syndromes ma myeloproliferative neoplasms.

• E i ai ituaiga eseese o myelodysplastic / myeloproliferative neoplasms.

• O suʻega e suʻesuʻe ai le toto ma ponaivi suʻesuʻe e faʻaaogaina e suʻe ai (mauaina) ma faʻamaonia neoplasms myelodysplastic / myeloproliferative.

Myelodysplastic / myeloproliferative neoplasms o se vaega o faʻamaʻi o le ponaivi ponaivi faia tele papaʻe sela toto.

Myelodysplastic / myeloproliferative neoplasms o faʻamaʻi o le toto ma ponaivi suo.

Anatomia o le ponaivi. O le ponaivi e faia i le ponaivi ponaivi, spongy ponaivi, ma ponaivi suo. O le ponaivi ponaivi e faia le pito i fafo o le ponaivi. Spongy ponaivi e maua tele i pito o ponaivi ma aofia ai mumu sisila. O ponaivi ponaivi e maua i le ogatotonu o le tele o ponaivi ma e tele ala toto. E lua ituaiga o ponaivi ponaivi: mumu ma samasama. O le suo mumu o loʻo i ai sela o le toto e mafai ona avea ma sela mumu, sela papaʻe, poʻo lapisi. Lanu samasama e faia tele i gaʻo.

O le masani ai, o le ponaivi ponaivi faia sela toto mafuaʻaga (le matua sela) e avea matutua sela sela i le taimi. O le toto totoga sela mafai ona avea ma myeloid totoʻa sela poʻo le lymphoid totoʻa sela. O le sela sela lymphoid avea ma sela toto papaʻe. O le sela sela myeloid avea ma se tasi o tolu ituaiga o matua toto sela:

• O sela mumu toto e aveina le okesene ma isi vailaʻau ile soʻoga o le tino.

• Paʻepaʻe toto e tauivi ma faʻamaʻi ma faʻamaʻi.

• Platelet e faia ai faʻaputuga toto e taofi ai le tafetoto.

Toto toto atinaʻe. O le toto sela sela ui atu i le tele o sitepu e avea o se mumu sela sela, sela, po o sela papaʻe sela.

Myelodysplastic / myeloproliferative neoplasms ei ai foliga o myelodysplastic syndromes ma myeloproliferative neoplasms.

I faʻamaʻi myelodysplastic, e leʻo matua sela o le toto i sela mumu toto, sela papaʻe papaʻe, poʻo lapisi. O sela le matua o le toto, e taʻua o le pa, e le galue i le auala e tatau ai ma feoti i le ponaivi o le ponaivi pe leʻi leva ona latou ulu atu i le toto. O lona iʻuga, e tau leai ni sela toto mumu maloloina, sela papaʻe papaʻe, ma sela malilie.

I faʻamaʻi myeloproliferative, o le sili atu i le masani numera o toto totoga sela avea ma tasi pe sili atu ituaiga o toto sela ma le aofaʻi atoa o sela toto lemu faʻateleina.

Lenei aotelega e faatatau i neoplasms o loʻo i ai foliga vaaia uma myelodysplastic ma myeloproliferative faʻamaʻi. Vaʻai i aotelega nei mo nisi faʻamatalaga e uiga i faʻamaʻi fesoʻotaʻi:

• Togafitiga Myelodysplastic Syndromes

• Togafitiga Myeloproliferative Neoplasms Togafitiga

• Togafitiga Myelogenous Leukemia faaumiumi

E i ai ituaiga eseese o myelodysplastic / myeloproliferative neoplasms.

O ituaiga autu e 3 o myelodysplastic / myeloproliferative neoplasms aofia ai mea nei:

• Leukemia masani ole myelomonosittic (CMML).

• Leukemia o le myelomonosittic juvenile (JMML).

• Atypical faaumiumi myelogenous leukemia (CML).

Pe a le fetaui le myelodysplastic / myeloproliferative neoplasm i se tasi o nei ituaiga, e taʻua o le myelodysplastic / myeloproliferative neoplasm, unclassifiable (MDS / MPN-UC).

Myelodysplastic / myeloproliferative neoplasms ono alualu i luma i matuitui leukemia.

O suʻega e suʻesuʻe ai le toto ma ponaivi suʻesuʻe e faʻaaogaina e suʻe ai (mauaina) ma faʻamaonia neoplasms myelodysplastic / myeloproliferative.

O suʻega ma faʻagaioiga nei e mafai ona faʻaaogaina:

• Suʻega faʻaletino ma talafaʻasolopito: O se suʻega o le tino e siaki faʻailoga lautele o le soifua maloloina, e aofia ai le siakiina o faʻailoga o faʻamaʻi pei o le faʻateleina o le ateatea ma le ate. O se talaʻaga o amioga maʻi o le tagata maʻi ma maʻi ua tuanaʻi ma togafitiga o le a faia foi.

• Faitau atoa le toto (CBC) ma le eseʻesega: O se faʻasologa e tosoina mai ai se faʻataʻitaʻiga o le toto ma siaki mo mea nei:

• Le numera o sela mūmū ma lapisi.

• Le numera ma le ituaiga sela papaʻe.

• Le aofaʻi ole hemoglobin (o le polotini e aveina le okesene) i sela mumu mumu.

• O le vaega o le faʻataʻitaʻiga e faia i sela mumu toto.

Faitau atoa le toto (CBC). E aoina le toto i le faʻaofiina o se nila i totonu o le alatoto ma faʻatagaina le toto e tafe i totonu o se paipa. O le faʻataʻitaʻiga ole toto ua lafo ile fale suesue ma ua faitauina sela mumu mumu, sela papaʻe o le tagata, ma platelet. O le CBC e faʻaaoga e suʻesuʻe ai, faʻamaonia, ma mataituina le tele o tuʻutuʻuga eseese.

• Peripheral toto smear: O se faʻasologa e siaki ai se faʻataʻitaʻiga o le toto mo sela pa, le aofaʻi ma ituaiga o sela papaʻe o le tino, le aofaʻi o papamaa, ma suiga i foliga o sela toto.

• Suʻesuʻega o le vailaʻau o le toto : O se faʻataʻitaʻiga e siaki ai le toto faʻataʻitaʻi e fua ai le aofaʻi o ni vailaʻau ua faʻasaʻolotoina i le toto e totoga ma aano o le tino. O se le masani ai (maualuga pe maualalo ifo nai lo le masani ai) aofaʻi o se vailaʻau mafai ona avea ma faʻailoga o faʻamaʻi.

• Ovi o le ponaivi ma le biopsy: O le aveʻesea o se tamaʻi ponaivi ma ponaivi i le faʻaofiina o se nila i le suilapalapa poʻo le susu. O se tagata poto faʻapitoa e vaʻai uma i vaega o ponaivi ma ponaivi i lalo o le microscope e vaʻai ai i sela le masani ai.

Ivi ponaivi manaʻomia ma biopsy. A maeʻa ona faʻamamaina sina tamaʻi vaega o le paʻu, ona tuu lea o le nila ivi i totonu ole ponaivi o le tagata maʻi. O faʻataʻitaʻiga o le toto, ponaivi, ma ponaivi gaʻo ua aveʻesea mo le suʻesuʻega i lalo ole microscope.

O suʻega ia e mafai ona faia i luga o le faʻataʻitaʻiga o aano o mea na aveʻesea:

• Suʻesuʻega ole Cytogenetic: O se suʻesuʻega ole fale suʻesuʻe e faitau ai ma siaki ai le chromosome o sela ile ponaivi o le ponaivi poʻo le toto mo soʻo se suiga, e pei ole gagau, misia, toe faʻatulagaina, poʻo ni chromosome faʻaopopo. Suiga i nisi chromosome ono avea ma faʻailoga o le kanesa. E faʻaogaina le suʻesuʻega ole Cytogenetic e fesoasoani ai ile faʻailoaina o le kanesa, fuafua togafitiga, pe faʻafefea ona aoga togafitiga. O sela kanesa i myelodysplastic / myeloproliferative neoplasms e le aofia ai le Philadelphia chromosome o loʻo i ai i le myelogenous leukemia masani.

• Immunocytochemistry: O se suʻesuʻega o suʻesuʻega e faʻaaoga ni vailaʻau e siaki ai ni antigens (markers) i se faʻataʻitaʻiga o le ponaivi o le ponaivi. O fualaʻau e masani ona fesoʻotaʻi i se vailaʻau oona poʻo le fluorescent dyye. A maeʻa ona fusifusia fusi i le antigen i le faʻataʻitaʻiga o le ponaivi ponaivi o le ponaivi, ua faʻagaoioia le enzyme poʻo le vali, ona mafai ai lea ona vaʻaia le antigen i lalo o le microscope. O lenei ituaiga suʻega e faʻaaoga e fesoasoani ai i le suʻesuʻeina o le kanesa ma taʻu ai le eseʻesega o le myelodysplastic / myeloproliferative neoplasms, leukemia, ma isi tulaga.

Laʻititi o le Myelomonocytic Leukemia

MANATU AUTU

• Leukemia masani o le myelomonosittic leukemia o se faamaʻi e oʻo ai le tele o myelosit ma monositita (sela paʻepaʻe papaʻe) faia i le ponaivi suo.

• Matua ma le matua tama faʻateleina le aʻafiaga o le tumau myelomonocytic leukemia.

• O faʻailoga ma faʻailoga o le masani ole myelomonocytic leukemia e aofia ai le fiva, paʻu o pauna, ma le lagona lelava tele.

• O nisi mea e afaina ai le vavalo (avanoa o le toe faʻaleleia) ma togafitiga filifiliga.

Leukemia masani o le myelomonosittic leukemia o se faamaʻi e oʻo ai le tele o myelosit ma monositita (sela paʻepaʻe papaʻe) faia i le ponaivi suo.

I taimi masani ole myelomonosittic leukemia (CMML), e taʻu atu ai e le tino le tele o sela toto e avea ma lua ituaiga sela papaʻe e taʻu o myelocytes ma monocytes. O nisi o sela toto nei e le taitai avea ma sela papaʻe papaʻe. O sela le paʻepaʻe nei e taʻua o le pa. I le aluga o taimi, o le myelocytes, monocytes, ma le pa e faʻateʻa ese ai sela mumu ma lapisi i le ponaivi ponaivi. A tupu lenei mea, faʻamaʻi, anemia, poʻo le vave alu toto mafai ona tupu.

Matua ma le matua tama faʻateleina le aʻafiaga o le tumau myelomonocytic leukemia.

Soo se mea e faʻateleina ai lou avanoa e maua ai i se faʻamaʻi e taʻua o se tulaga lamatia. O mea ono ono tutupu mai mo le CMML aofia ai mea nei:

• Matua tausaga.
• Avea ma tama.
• Faʻaalia i nisi vailaʻau ile galuega poʻo le siʻosiʻomaga.
• Faʻaalia i le radiation.
• Togafitiga ua tuanai ma nisi vailaʻau anticancer.

O faʻailoga ma faʻailoga o le masani ole myelomonocytic leukemia e aofia ai le fiva, paʻu o pauna, ma le lagona lelava tele.

O nei ma isi faʻailoga ma faʻailoga e ono mafua mai i le CMML poʻo isi tulaga. Siaki i lau fomaʻi pe a iai sau mea nei:

• Fiva e aunoa ma se mafuaʻaga lauiloa.
• Siama
• Lagona ua matua lelava.
• Paʻu pauna mo leai se mafuaaga lauiloa.
• Faigofie gagala pe puna toto.
• Paʻu poʻo se lagona o le tumu i lalo o ivi asoaso.

O nisi mea e afaina ai le vavalo (avanoa o le toe faʻaleleia) ma togafitiga filifiliga.

O le vavalo (avanoa o le toe faʻaleleia) ma togafitiga togafitiga mo CMML faʻamoemoe i mea nei:

• Ole numera o sela papaʻe ile palapala poʻo ponaivi ivi.

• Pe o le onosaʻi o le siama.

• Le aofaʻi o pa i le toto poʻo ponaivi ivi.

• Le aofaʻi ole hemoglobin i sela mumu toto.

• Pe i ai ni mautinoa suiga i le chromosome.

Juvenile Myelomonocytic Leukemia

MANATU AUTU

• O le leukemia o le myelomonosittic juvenile o se maʻi o tamaiti ao oʻo ai le tele o myelosit ma monositita (sela paʻepaʻe papaʻe) e faia i le ponaivi ponovi.

• O faʻailoga ma faʻailoga o le leukemia o le myelomonocytic o tamaiti e aofia ai le fiva, paʻu o pauna, ma le lagona lelava.

• O nisi mea e afaina ai le vavalo (avanoa o le toe faʻaleleia) ma togafitiga filifiliga.

O le leukemia o le myelomonosittic juvenile o se maʻi o tamaiti ao oʻo ai le tele o myelosit ma monositita (sela paʻepaʻe papaʻe) e faia i le ponaivi ponovi.

Juvenile myelomonocytic leukemia (JMML) o se kanesa o tamaiti e seasea tupu e masani ona tupu i tamaiti laiti nai lo le 2 tausaga. Tamaiti o loʻo maua le neurofibromatosis ituaiga 1 ma aliʻi ua tele le aʻafiaga o le laumemia myelomonosittic tamaiti.

I le JMML, e taʻu atu ai e le tino i le tele o sela totoʻa e avea ma lua ituaiga sela papaʻe e taʻu o myelocytes ma monocytes. O nisi o sela toto nei e le taitai avea ma sela papaʻe papaʻe. O sela le paʻepaʻe nei e taʻua o le pa. I le aluga o taimi, o le myelocytes, monocytes, ma le pa e faʻateʻa ese ai sela mumu ma lapisi i le ponaivi ponaivi. A tupu lenei mea, faʻamaʻi, anemia, poʻo le vave alu toto mafai ona tupu.

O faʻailoga ma faʻailoga o le leukemia o le myelomonocytic o tamaiti e aofia ai le fiva, paʻu o pauna, ma le lagona lelava.

O nei ma isi faʻailoga ma faʻailoga e ono mafua mai i le JMML poʻo isi tulaga. Siaki i lau fomaʻi pe a iai sau mea nei:

• Fiva e aunoa ma se mafuaʻaga lauiloa.

• Mauaina faʻamaʻi, pei o le bronchitis poʻo le tonsillitis.

• Lagona ua matua lelava.

• Faigofie gagala pe puna toto.

• Paʻu mageso.

• Fula le faʻamamaina o lymph nodes i le ua, underarm, manava, poʻo oga.

• Paʻu poʻo se lagona o le tumu i lalo o ivi asoaso.

O nisi mea e afaina ai le vavalo (avanoa o le toe faʻaleleia) ma togafitiga filifiliga.

O le vavalo (avanoa o le toe faʻaleleia) ma togafitiga togafitiga mo JMML faʻamoemoe i mea nei:

• Le matua ole tamaititi ile faʻamaoniga.

• O le aofaʻi o papamaa i le toto.

• Ole aofaʻiga ole ituaiga hemoglobin ile mumu toto.

Atypical Chronic Myelogenous Leukemia

MANATU AUTU

• Atypical faaumiumi myelogenous leukemia o se faamaʻi lea e tele naua granulosit (sela le matua o le toto) faia i le ponaivi suo.

• Faailoga ma auga o le masani ai myelogenous leukemia masani e aofia ai le faigofie ona gagase poʻo le palapala toto ma lagona le lelava ma vaivai.

• O nisi mea e afaina ai le vavalo (avanoa o le toe faʻaleleia).

Atypical faaumiumi myelogenous leukemia o se faamaʻi lea e tele naua granulosit (sela le matua o le toto) faia i le ponaivi suo.

I le atypical masani myelogenous leukemia (CML), o le tino taʻu atu tele sela totoga sela e avea ma se ituaiga o papaʻe sela toto taʻua o granulocytes. O nisi o sela toto nei e le taitai avea ma sela papaʻe papaʻe. O sela le paʻepaʻe nei e taʻua o le pa. I le aluga o taimi, o le granulocytes ma le pa e faʻataʻamilomiloina i fafo le mumu sela ma lapisi i le ponaivi suo.

O sela ole lukimia i atypical CML male CML e foliga tutusa i lalo ole microscope. Peitaʻi, i le faʻafuaseʻi CML o se suiga o le chromosome, e taʻua o le "Philadelphia chromosome" e leʻo iai.

Faailoga ma auga o le masani ai myelogenous leukemia masani e aofia ai le faigofie ona gagase poʻo le palapala toto ma lagona le lelava ma vaivai.

O nei ma isi faʻailoga ma faʻailoga e ono mafua mai i le le fiafia CML poʻo isi tulaga. Siaki i lau fomaʻi pe a iai sau mea nei:

• Manava le mānava.

• Paʻu paʻu.

• Lagona ua matua lelava ma vaivai.

• Faigofie gagala pe puna toto.

• Petechiae (mafolafola, faʻailoga tonu i lalo ole paʻu mafua mai ile toto).

• Paʻu poʻo se lagona o le tumu i lalo o ivi asoaso i le itu agavale.

O nisi mea e afaina ai le vavalo (avanoa o le toe faʻaleleia).

O le vavalo (avanoa o le toe faʻaleleia) mo atypical CML faʻamoemoe i le numera o mumu toto sela ma platelets i le toto.

Myelodysplastic / Myeloproliferative Neoplasm, Le faʻavasegaina

MANATU AUTU

• Myelodysplastic / myeloproliferative neoplasm, e le mafai ona faʻamatalaina, o se faʻamaʻi o loʻo i ai foliga uma o myelodysplastic ma myeloproliferative faʻamaʻi ae e le o le tumau myelomonocytic leukemia, juvenile myelomonosittic leukemia, po o le atypical myelogenous leukemia.

• Faʻailoga ma faʻailoga o le myelodysplastic / myeloproliferative neoplasm, le mafai ona faʻamatalaina, aofia ai fiva, paʻu pauna, ma lagona lelava tele.

Myelodysplastic / myeloproliferative neoplasm, e le mafai ona faʻamatalaina, o se faʻamaʻi o loʻo i ai foliga uma o myelodysplastic ma myeloproliferative faʻamaʻi ae e le o le tumau myelomonocytic leukemia, juvenile myelomonosittic leukemia, po o le atypical myelogenous leukemia.

I le myelodysplastic / myeloproliferative neoplasm, e le mafai ona faʻamatalaina (MDS / MPD-UC), ua taʻu atu ai e le tino le tele o sela toto e avea ma sela mumu toto, sela papaʻe papaʻe, poʻo lapisi. O nisi o nei sela sela ua le mafai ona avea ma sela matua. O nei sela le matua o le toto ua taʻua o le pa. I le aluga o taimi, o sela le masani ai o le toto ma pa i le ponaivi pono mafu ese mai maloloina maloloina toto mumu, papaʻe sela toto, ma platelet

MDS / MPN-UC o se faʻamaʻi e seasea maua. Talu ai e seasea lava, o mafuaʻaga e afaina ai lamatiaga ma vavalo e le o iloa.

Faʻailoga ma faʻailoga o le myelodysplastic / myeloproliferative neoplasm, le mafai ona faʻamatalaina, aofia ai fiva, paʻu pauna, ma lagona lelava tele.

O nei ma isi faʻailoga ma faʻailoga e ono mafua mai i le MDS / MPN-UC poʻo isi tulaga. Siaki i lau fomaʻi pe a iai sau mea nei:

• Fiva poʻo faʻamaʻi masani.

• Manava le mānava.

• Lagona ua matua lelava ma vaivai.

• Paʻu paʻu.

• Faigofie gagala pe puna toto.

• Petechiae (mafolafola, faʻailoga tonu i lalo ole paʻu mafua mai ile toto).

• Paʻu poʻo se lagona o le tumu i lalo o ivi asoaso.

Vaega o Myelodysplastic / Myeloproliferative Neoplasms

MANATU AUTU

• E leai se tulaga faʻavae tulaga mo myelodysplastic / myeloproliferative neoplasms.

E leai se tulaga faʻavae tulaga mo myelodysplastic / myeloproliferative neoplasms.

O le faʻagaioia o se auala e faʻaaoga e suʻe ai pe o le a le mamao ua sosolo ai le kanesa. E leai se tulaga faʻavae tulaga mo myelodysplastic / myeloproliferative neoplasms. Togafitiga e faʻavae i luga ole ituaiga ole myelodysplastic / myeloproliferative neoplasm o loʻo i le tagata maʻi. E taua le iloa o le ituaiga ina ia mafai ona fuafua togafitiga.

Togafitiga Option Vaaiga lautele

MANATU AUTU

• E i ai ituaiga eseese o togafitiga mo tagata mamaʻi ma myelodysplastic / myeloproliferative neoplasms.

• E lima ituaiga togafitiga faʻapitoa e faʻaaogaina:

• Chemotherapy

• Isi togafitiga o vailaʻau

• Tui sela sela

• Tausiga lagolago

• Fuafua togafitiga

• Fou ituaiga o togafitiga o loʻo faʻataʻitaʻia i falemaʻi tofotofoga.

• Togafitiga mo myelodysplastic / myeloproliferative neoplasms ono mafua ai aʻafiaga.

• Tagata gasegase ono manaʻo e mafaufau e uiga i le auai i le faʻataʻitaʻiina o togafitiga.

• E mafai e tagata maʻi ona ulufale i faʻataʻitaʻi i falemaʻi muamua, i le taimi pe amataina o latou kanesa.

• Atonu e manaʻomia ni suʻega tulitatao.

E i ai ituaiga eseese o togafitiga mo tagata mamaʻi ma myelodysplastic / myeloproliferative neoplasms.

Eseese ituaiga o togafitiga e avanoa mo tagata mamaʻi ma myelodysplastic / myeloproliferative neoplasms. Nisi togafitiga e masani (o le taimi nei faʻaogaina togafitiga), ma nisi o loʻo tofotofoina i falemaʻi tofotofoga. O se togafitiga faʻafomaʻi faʻataʻitaʻi o se suʻesuʻega suʻesuʻega e fesoasoani e faʻaleleia ai togafitiga i le taimi nei pe maua ai faʻamatalaga i fou togafitiga mo tagata mamaʻi ma kanesa. A faʻataʻitaʻia faʻataʻitaʻi falemaʻi o se togafitiga fou e sili atu le lelei nai lo le faʻataʻitaʻiga masani, o le togafitiga fou e mafai ona avea ma masani togafitiga. Tagata gasegase ono manaʻo e mafaufau e uiga i le auai i le faʻataʻitaʻiina o togafitiga. O faʻataʻitaʻi faʻafomaʻi e naʻo tagata mamaʻi e leʻi amataina togafitiga.

E lima ituaiga togafitiga faʻapitoa e faʻaaogaina:

Chemotherapy

Chemotherapy o se kanesa togafitiga e faʻaaogaina ai vailaʻau e taofi ai le tuputupu aʻe o kanesa sela, a le o le fasiotia o sela poʻo le taofiina latou mai le vaeluaina. A o le chemotherapy e ave e le gutu pe tui i totonu o le uaua poʻo musele, o vailaʻau e ulufale i le toto ma mafai ona oʻo atu i kanesa sela i le tino atoa (systemic chemotherapy). A tuʻu saʻo le chemotherapy i le vai o le cerebrospinal, o se okeni, poʻo se tino o le tino e pei o le manava, o vailaʻau e tele lava ina aʻafia ai sela o le kanesa i na eria (chemotherapy faʻaitumalo). O le auala e tuʻuina atu ai le chemotherapy e faʻamoemoe i le ituaiga ma le tulaga o le kanesa o loʻo togafitia. O le tuʻufaʻatasia o le chemotherapy o se togafitiga e faʻaaogaina ai le sili atu ma le tasi vailaʻau anticancer.

Vaʻai Vailaʻau Faʻamaonia mo Myeloproliferative Neoplasms mo nisi faʻamatalaga.

Isi togafitiga o vailaʻau

13-cis retinoic acid o se vailaʻau-pei o vailaʻau e telegese ai le mafai o le kanesa e faia sili kanesa sela ma suia le ala o nei sela vaʻaia ma gaioiga.

Tui sela sela

Chemotherapy ua tuuina atu e fasioti le masani ai sela po o sela kanesa. O sela maloloina, e aofia ai sela faiai toto, ua faʻaleagaina foʻi e togafitiga o le kanesa. Stem cell transplant o se togafitiga e sui ai le toto-fausia sela. O sela (poʻo leʻo toto sela) e aveʻese mai le toto poʻo le ponaivi o le tagata maʻi poʻo le tagata foaʻi ma ua faʻisaina ma teuina. A maeʻa ona faʻamaeʻa e le tagata maʻi le chemotherapy, o sela na faʻapipiʻiina o sela na sela ma toe avatu i le tagata maʻi e ala i se faʻasologa. O sela totoʻa na toe faʻatuina e tutupu i totonu (ma toe faʻafoʻi) sela toto o le tino.

Tui sela sela. (Sitepu 1): O le toto e aveʻesea mai le alatoto i le lima o le tagata foaʻi. O le onosaʻi poʻo seisi tagata ono avea ma le foaʻi. O le toto e tafe atu i totonu o se masini e aveʻesea ai sela sela. Ona toe faʻafoʻi lea o le toto i le tagata foaʻi e ala i le alatoto i le isi lima. (Sitepu 2): E maua e le tagata maʻi le chemotherapy e fasioti ai sela fai toto. E mafai ona maua e le tagata maʻi le togafitiga o le radiation (e le faʻaalia) (Sitepu 3): E maua e le tagata maʻi sela sela e ala i le catheter ua tuu i totonu o se alatoto toto i le pusa.

Tausiga lagolago

Fesoasoani tausi e aveina e faʻaititia ai faʻafitauli e mafua mai le faʻamaʻi poʻo ona togafitiga. Lagolago lagolago ono aofia ai togafitiga tui poʻo vailaʻau togafitiga, pei o vailaʻau faʻafomaʻi e tau ai siama.

Fuafua togafitiga

O togafitiga faʻataʻitaʻia o se togafitiga o le kanesa e faʻaaogaina fualaʻau poʻo isi vailaʻau e osofai ai sela o le kanesa e aunoa ma le faʻaleagaina o sela masani. O vailaʻau faʻasolosolo e faʻaigoaina o le tyrosine kinase inhibitors (TKI) e faʻaaoga e togafitia ai myelodysplastic / myeloproliferative neoplasm, e le mafai ona faʻamatalaina. TKIs poloka le enzyme, tyrosine kinase, e mafua ai sela sela ia avea atili sela toto (blasts) nai lo le tino manaʻomia. Imatinib mesylate (Gleevec) o se TKI e mafai ona faʻaaogaina. O loʻo suʻesuʻeina isi vailaʻau togafitiga i le togafitiga o le JMML.

Vaʻai Vailaʻau Faʻamaonia mo Myeloproliferative Neoplasms mo nisi faʻamatalaga.

Fou ituaiga o togafitiga o loʻo faʻataʻitaʻia i falemaʻi tofotofoga.

Faʻamatalaga e uiga i falemaʻi tofotofoga e avanoa mai le NCI 'upega tafaʻilagi.

Togafitiga mo myelodysplastic / myeloproliferative neoplasms ono mafua ai aʻafiaga.

Mo faʻamatalaga e uiga i aʻafiaga e mafua mai i togafitiga mo kanesa, vaʻai la matou Itu Itu Aʻoga itulau.

Tagata gasegase ono manaʻo e mafaufau e uiga i le auai i le faʻataʻitaʻiina o togafitiga.

Mo nisi tagata mamaʻi, o le auai i le faʻataʻitaʻiina o le falemaʻi atonu o le filifiliga sili lea ona lelei. O faʻataʻitaʻiga faʻafomaʻi o vaega ia o suʻesuʻega o le kanesa. O faʻataʻitaʻi faʻafomaʻi togafitiga e faia ia iloa ai pe o saogalemu ma aoga pe sili atu le lelei o togafitiga o kanesa fou nai lo le togafitiga masani.

Ole tele o aso nei togafitiga masani mo le kanesa e faʻavae i luga o muamua falemaʻi tofotofoga. Tagata mamaʻi na auai i le faʻataʻitaʻiina o faʻataʻitaʻi mafai ona maua le faʻasologa masani pe i ai i le muamua e mauaina se faʻafouga fou.

O tagata mamaʻi e auai i faʻataʻitaʻiina o falemaʻi e fesoasoani foi e faʻaleleia le auala e togafitia ai le kanesa i le lumanaʻi. Tusa lava pe le faʻataʻitaʻia togafitiga faʻamalositino i ni togafitiga fou lelei, latou te masani ona taliina fesili taua ma fesoasoani e faʻagasolo i luma suʻesuʻega.

E mafai e tagata maʻi ona ulufale i faʻataʻitaʻi i falemaʻi muamua, i le taimi pe amataina o latou kanesa.

Nisi faʻataʻitaʻi faʻamasinoga e naʻo tagata mamaʻi e leʻi mauaina togafitiga. O isi tofotofoga faʻataʻitaʻi togafitiga mo tagata mamaʻi o latou kanesa ua le maua sili lelei. E i ai foʻi faʻataʻitaʻi faʻataʻitaʻi e faʻataʻitaʻia ni auala fou e taofi ai le kanesa mai le toe tupu (toe foʻi mai) pe faʻaititia itu leaga o togafitiga o le kanesa.

O loʻo fai faʻataʻitaʻi ile falemaʻi ile tele o vaega ole atunuʻu. Faʻamatalaga e uiga i falemaʻi tofotofoga lagolagoina e NCI mafai ona maua i luga o NCI o falemaʻi suʻesuʻega suʻega itulau web. O faʻataʻitaʻi faʻapitoa e lagolagoina e isi faʻalapotopotoga e mafai ona maua i luga o le upega tafailagi a le ClinicalTrials.gov.

Atonu e manaʻomia ni suʻega tulitatao.

O nisi o suʻega na faia e suʻe ai le kanesa pe maua ai le tulaga o le kanesa atonu e toe faia. O nisi suʻega o le a toe faia ina ia iloa ai pe faʻafefea ona lelei le togafitiga. O faʻaiuga pe faʻaauau, suia, pe taofi togafitiga e ono faʻavae i luga o iʻuga o nei suʻega.

O nisi o suʻega o le a faʻaauau ona faia mai lea taimi i lea taimi pe a maeʻa togafitiga. O iʻuga o nei suʻega e mafai ona faʻaalia pe ua suia lou tulaga pe ua toe fai le kanesa (toe foʻi mai). O nei suʻega e taʻua i nisi taimi o suʻega tulitatao poʻo siaki siaki.

Togafitiga togafitiga mo Myelodysplastic / Myeloproliferative Neoplasms

I Lenei Vaega

• Laʻititi o le Myelomonocytic Leukemia

• Juvenile Myelomonocytic Leukemia

• Atypical Chronic Myelogenous Leukemia

• Myelodysplastic / Myeloproliferative Neoplasm, Le faʻavasegaina

Mo faʻamatalaga e uiga i togafitiga o loʻo lisi atu i lalo, vaʻai le vaega Option o Togafitiga Otootoga vaega.

Laʻititi o le Myelomonocytic Leukemia

Togafitiga o le tumau myelomonocytic leukemia (CMML) ono aofia ai mea nei:

• Chemotherapy ma se tasi pe sili atu sooupu.

• Tui sela sela.

• O se falemaʻi faʻataʻitaʻia o se fou togafitiga.

Faʻaaoga la matou suʻesuʻega faʻasolosolo suʻesuʻega e saili ai faʻamaʻi o le kanesa o loʻo lagolagoina e le NCI o loʻo taliaina tagata mamaʻi. E mafai ona e suʻesuʻeina suʻega faʻavae i le ituaiga kanesa, le matua o le tagata maʻi, ma le mea o loʻo faia ai faʻamasinoga. Lautele faʻamatalaga e uiga i falemaʻi tofotofoga o loʻo avanoa foi.

Juvenile Myelomonocytic Leukemia

Togafitiga o le myelomonocytic leukemia (JMML) e mafai ona aofia ai mea nei:

• Tuufaatasi chemotherapy.

• Tui sela sela.

• 13-cis-retinoic acid togafitiga.

• O se falemaʻi faʻataʻitaʻia o se togafitiga fou, e pei o faʻatulagaina togafitiga.

Faʻaaoga la matou suʻesuʻega faʻasolosolo suʻesuʻega e saili ai faʻamaʻi o le kanesa o loʻo lagolagoina e le NCI o loʻo taliaina tagata mamaʻi. E mafai ona e suʻesuʻeina suʻega faʻavae i le ituaiga kanesa, le matua o le tagata maʻi, ma le mea o loʻo faia ai faʻamasinoga. Lautele faʻamatalaga e uiga i falemaʻi tofotofoga o loʻo avanoa foi.

Atypical Chronic Myelogenous Leukemia

Togafitiga o atypical masani myelogenous leukemia (CML) ono aofia ai chemotherapy.

Faʻaaoga la matou suʻesuʻega faʻasolosolo suʻesuʻega e saili ai faʻamaʻi o le kanesa o loʻo lagolagoina e le NCI o loʻo taliaina tagata mamaʻi. E mafai ona e suʻesuʻeina suʻega faʻavae i le ituaiga kanesa, le matua o le tagata maʻi, ma le mea o loʻo faia ai faʻamasinoga. Lautele faʻamatalaga e uiga i falemaʻi tofotofoga o loʻo avanoa foi.

Myelodysplastic / Myeloproliferative Neoplasm, Le faʻavasegaina

Ona ole myelodysplastic / myeloproliferative neoplasm, e le mafai ona faʻamatalaina (MDS / MPN-UC) o se faʻamaʻi seasea, e laitiiti se mea e iloa e uiga i ona togafitiga. Togafitiga ono aofia ai mea nei:

• Togafitiga fesoasoani lagolago e faʻatonutonu ai faʻafitauli e mafua mai le faʻamaʻi pei o siama, toto, ma le anemia

• Fuafua togafitiga (imatinib mesylate).

Faʻaaoga la matou suʻesuʻega faʻasolosolo suʻesuʻega e saili ai faʻamaʻi o le kanesa o loʻo lagolagoina e le NCI o loʻo taliaina tagata mamaʻi. E mafai ona e suʻesuʻeina suʻega faʻavae i le ituaiga kanesa, le matua o le tagata maʻi, ma le mea o loʻo faia ai faʻamasinoga. Lautele faʻamatalaga e uiga i falemaʻi tofotofoga o loʻo avanoa foi.

Ia Aʻoaʻo atili e uiga i Myelodysplastic / Myeloproliferative Neoplasms

Mo nisi faʻamatalaga mai le National Cancer Institute e uiga i myelodysplastic / myeloproliferative neoplasms, vaʻai i mea nei:

• Myeloproliferative Neoplasms Fale Itulau

• Tauiina o sela feaveaʻi le toto

• Fualaʻau Faʻamaonia mo Myeloproliferative Neoplasms

• Fuafua Kanesa Faʻamoemoeina

Mo faʻamatalaga lautele o le kanesa ma isi mea taua mai le National Cancer Institute, vaʻai i mea nei:

• E uiga i le kanesa

• Faʻavaeina

• Chemotherapy ma Oe: Lagolago mo Tagata Maʻi Kanesa

• Radiation Therapy ma Oe: Lagolago mo Tagata e I ai le Kanesa

• Faʻafitauli ma le Kanesa

• Fesili e Fesili ai Lau Fomaʻi e uiga i le Kanesa

• Mo Tagata Faasao ma Tagata Taʻitaʻi