Suesuega / vaega / falemaʻi-tofotofoga / nctn

NCTN: NCI's National Clinical Trials Network

Vaʻai mo lenei faʻailoga i le auai i faʻalapotopotoga Network ma faʻalapotopotoga. O lona uiga ua faʻamanuiaina i latou e le National Cancer Institute (NCI) o se sui o le NCI National Clinical Trials Network (NCTN).

NCI's National Clinical Trials Network (NCTN) o se faʻaputuga o faʻalapotopotoga ma fomaʻi e faʻamaopoopo ma lagolagoina faʻafitauli o le kanesa i le kanesa i le sili atu i le 2,200 nofoaga i le salafa o le Iunaite Setete, Kanata, ma faʻavaomalo. NCTN o loʻo faʻaavanoaina mea tetele mo togafitiga faʻatupeina e le NCI ma faʻataʻitaʻiga muamua o faʻataʻitaʻiga o ata e faʻaleleia ai olaga o tagata e maua i le kanesa.

NCTN falemaʻi faʻataʻitaʻi fesoasoani e faʻatuina ni tulaga fou o le tausiga, faʻatulaga le tulaga mo le faʻamaonia o fou togafitiga e le Taumafa ma Vailaau Faʻafoeina, faʻataʻitaʻi togafitiga fou auala, ma faʻamaonia fou biomarkers.

Na faʻalauiloa e le NCI le tele o faʻamasinoga e ala ile NCTN, e aofia ai:

• ALCHEMIST: Adjuvant Lung Cancer Enrichment Marker Identification ma Faasologa Faigata

• DART: Dual Anti-CTLA-4 ma Anti-PD-1 Blockade i Rare Tumors Faʻamasinoga

• Lung-MAP: Vaega II / III Biomarker-Driven Master Protocol mo le Second Line Therapy mo uma Advanced Stage Non-Small Cell Lung Cancers

• NCI-MATCH: Molecular Analysis mo Therapy Filifiliga mo tagata matutua ma kanesa maualuluga

• NCI-COG Pediatric MATCH: Molecular Analysis mo Therapy Filifiliga mo tamaiti ma talavou matutua ma kanesa maualuluga

• NCI-NRG ALK Master Protocol: O le suʻesuʻeina e le biomarker mo tagata na muamua togafitia ALK-lelei e leʻo faʻataʻitaʻi tagata NSCLC.

Vaega o Fesoʻotaʻiga ma a latou Vaega Lagolago

O le faʻalapotopotoga o faʻalapotopotoga e lelei tele mo le suʻesuʻeina o numera o tagata mamaʻi e suʻe ai latou o latou tuma faʻaalia foliga o le molela e maua ai le avanoa sili e tali atu ai i togafitiga fou. Mo fomaʻi ma latou gasegase, o se lisi o taua taua faʻataʻitaʻi o loʻo avanoa lautele i le atunuʻu, i taulaga tetele ma tamaʻi nuʻu tutusa. NCTN ofa atu i auala sili ona lelei e avanoa mo le tele o masani ma, faʻateleina, e oʻo lava i kanesa faigata.

Vaʻavaʻaia o le NCTN — o lona faʻalapotopotoga faʻavae, faʻatupeina, ma se taʻiala umi mo se taimi umi - o loʻo i lalo o le vaaiga a le Komiti Faufautua o Suʻesuʻega Faʻataʻitaʻi (CTAC). O lenei komiti faufautua feterale e aofia ai fomaʻi faʻataʻitaʻi faʻataʻitaʻi, kamupani matata, ma onosaʻi fautua mai le salafa o le malo ma tuʻuina atu fautuaga i le NCI faatonu.

O le faʻatulagaina o le NCTN e aofia ai vaega e lima a le US Network ma le Canada Collaborating Clinical Trials Network. Sui auai i vaega taʻitasi NCTN e faʻavae i luga o taʻiala e faʻapitoa i vaega taʻitasi. Nofoaga mafai ona auai i le sili atu ma le tasi kulupu, ma avea ma sui auai i le le itiiti ifo ma le tasi le kulupu faʻatagaina se 'upega tafaʻilagi e auai i faʻataʻitaʻiga taʻitaʻia e soʻo se NCTN kulupu e faʻamaonia ai a latou tagata suʻesuʻe. O le mea lea, o tagata suʻesuʻe mai le LAPS, NCORP, isi nofoaga faʻaleaʻoaʻoga, faʻatinoga a le nuʻu, ma sui faʻavaomalo o loʻo fesoʻotaʻi ma vaega a le Network, e mafai uma ona lesitala tagata mamaʻi i faʻataʻitaʻiga NCTN. O faʻataʻitaʻi faʻataʻitaʻi na taʻitaʻia e vaega a le NCTN e ono maua le lagolago mai le IROC Group, ITSAs, ma sela o aitalafu, e tusa ma manaʻoga faasaienitisi o tofotofoga.

Vaega o Fesoʻotaʻiga

O le NCTN e aofia ai le fa vaega matutua ma le tasi vaega tele taulai atu lava i tamaiti laiti kanesa. O le faʻavae e aofia ai foʻi le Canada Collaborating Clinical Trials Network. O le lima US Network Groups o:

• Alliance for Clinical Trials i le OncologyExit Disclaimer

• ECOG-ACRIN Kanesa Suesuega KanesaExit Faʻafitauli

• NRG OncologyExit Faʻalauiloa

• SWOGExit Faʻalauiloa

• Tamaiti Oncology Vaega (COG) Exit Faʻafitauli

E faʻatupeina vaega taʻitasi a le US e ala ile lua tuʻufaʻatasi faailoga - tasi e lagolago le Network Operations ma leisi e lagolago le Statistics ma Data Management Centres. O le Nofoaga Autu Center e nafa ma le atiaʻe fou aiaiga ma puleaina le faʻatonutonu, tupe, sui ma saienitisi komiti o vaega taʻitasi. O Nofoaga Faʻafuainumera Nofoaga e tali atu mo faʻamatalaga faʻatautaia ma auiliiliga, tusitusiga tusitusiga, ma le saogalemu mataʻituina, i se faʻaopopoga i le fesoasoani i faʻataʻitaʻiga tisaini ma atinaʻe.

O paaga a le Canada Network Group ma paʻaga a le US Network Groups i le faʻatautaia o filifiliga, tuai-vaega, faʻataʻitaʻiga o falemaʻi e tele nofoaga. O le Canada Network Group o:

• Kanesa Kanata Faʻataʻitaʻiga Kanesa (CCTG) Tuua Teteʻe

O le Nofoaga Faʻagaioiga ma Fuainumera Nofoaga mo NCTN kulupu taʻitasi e vavaeʻeseʻeseʻeseʻe ae galulue faʻatasi. E masani ona tu i latou i se aʻoga faʻaleaʻoaʻoga na ofaina e "fale" le kulupu; ae ui i lea, i le tele o tulaga, o se nofoaga tutotonu o loʻo tu i se nofoaga tutoʻatasi o loʻo faʻatupeina e ala i se faʻavae faʻavae. Pau lava le tuusaunoaina i luga atu o le Canada Collaborating Clinical Trials Network, lea na mauaina le tasi faʻailoga mo lana Faʻagaioiga ma Fuainumera Nofoaga Autu.

Nofoaga Aʻoga Auai Mautinoa Nofoaga (LAPS)

E tolusefulu-lua US aoga faʻaleaʻoaʻoga ua maua le faʻatauaina Aʻoaʻoga Auai Auai Lisi (LAPS) foaʻi, o se puna o faʻatupega fausiaina faapitoa mo le NCTN. O 'upega tafaʻilagi o loʻo avea ma suʻesuʻega faʻaleaʻoaʻoga faʻatasi ma polokalame faʻataʻitaʻi, ma o le toʻatele o i latou ua mauaina o NCI-Designated Cancer Centres. Ina ia mauaina nei faʻailoga, saite e tatau ona faʻaalia lo latou agavaʻa e lesitala maualuga numera o tagata mamaʻi i faʻataʻitaʻiga NCTN, faʻapea foʻi ma taʻitaʻi faʻasaienisi i le tusiaina ma faʻatautaia o faʻataʻitaʻi falemaʻi.

Le 32 LAPS fesoasoani o:

Tulaga Iunivesite Faʻataua Reserve - Mataupu Maea Atoatoa Maʻi Kanesa Dana Farber / Harvard Kanesa Center

Duke Cancer Institute i le Duke University Medical Center

Iunivesite Emory - Winship Cancer Institute

Fred Hutchinson Kanesa Suesuega

Johns Hopkins University - Sidney Kimmel Comprehensive Kanesa Center

Mayo Falemai Kanesa Nofoaga Autu

Kolisi Faʻafomaʻi o Wisconsin

Faʻamanatuga Sloan Kettering Kanesa Nofoaga

Norris Cotton Cancer Center i le Dartmouth Hitchcock Medical Center

Northwestern University - Robert H. Lurie Atoa Maʻi Tutotonu Kanesa

O le Iunivesite o le Setete o Ohio

Roswell Park Kanesa Inisetiute

Sidney Kimmel Cancer Center i le Jefferson Health

Iunivesite o Alabama i Birmingham

Iunivesite o Kalefonia Davis Comprehensive Cancer Center

Iunivesite o Chicago Comprehensive Cancer Center

Iunivesite o Colorado Kanesa Center

Iunivesite o Michigan Maopoopo Nofoaga Tutotonu Kanesa

Iunivesite o North Carolina Lineberger Comprehensive Cancer Center

Iunivesite o Oklahoma - Stephenson Cancer Center

Iunivesite o Pittsburgh Kanesa Inisetiute

Iunivesite o Rochester Wilmot Kanesa Inisetiute

Iunivesite o Kalefonia i Saute - Norris Comprehensive Cancer Center

Iunivesite o Texas MD Anderson Kanesa Center

Iunivesite o Texas Southwestern Medical Center - Harold C. Simmons Kanesa Center

Iunivesite o Iuta - Huntsman Cancer Institute

Iunivesite o Wisconsin Carbone Cancer Center

Vanderbilt University Medical Center - Vanderbilt Ingram Kanesa Tutotonu

Washington University i St.Louis - Siteman Cancer Center

Wayne State University Barbara Ann Karmanos Kanesa Institute

Iunivesite a Yale - Yale Cancer Center

Maualuga tulaga o le onosai lesitala manaʻomia se lagolagoina tulaga o pulega faʻamaumauga galuega i le tele o tausaga, ma le LAPS foaʻi lagolagoina le aufaigaluega suʻesuʻe manaʻomia e faʻatautaia lenei taumafaiga. O tupe na faʻatupeina ile LAPS foaʻi e ufiufi ai lenei siʻitia galuega ua siʻitia lelei le siʻitia o le totogi o tagata taʻitasi i nofoaga filifilia.

O faʻailoga LAPS o loʻo maua ai foʻi faʻatupeina mo taʻitaʻi faʻasaienisi ma faʻataʻitaʻi i le tulaga lava ia, ona o le au suʻesuʻe autu i luga o le upega tafailagi e manaʻomia le faʻamuamuaina o faʻataʻitaʻiga o falemaʻi latou te auai ai, faʻapea foi ma le aʻoaʻoina ma aʻoaʻo tagata faigaluega i nofoaga i suʻesuʻega faʻafomaʻi ma atinaʻe metotia e faʻalauiloa ai le lesitalaina o tagata maʻi.

Falemai ma Falemai Nofoaga

Ole tele o isi tagata suʻesuʻe ile falemaʻi ma falemaʻi e mafai ona auai ile faʻataʻitaʻiga ole NCTN, tusa lava pe o iai i nofoaga e leʻi mauaina le faʻailoga LAPS. O nei 'upega tafaʻilagi, faʻapea foʻi ma le tele o tulaga faʻavaomalo, a le o mauaina tuʻusaʻo le totogiina o suʻesuʻega mai se tasi o vaega o fesoʻotaʻiga latou te fesoʻotaʻi pe latou te mauaina faʻailoga mai le NCI Community Oncology Research Program (NCORP).

Nofoaga auai i vaega taʻitasi NCTN e faʻavae i luga o taʻiala e faʻapitoa i vaega taʻitasi. Nofoaga faʻatautaia falemaʻi tofotofoga mafai ona auai i le sili atu ma le tasi kulupu, ma avea ma sui auai i le le itiiti ifo ma le tasi kulupu faʻatagaina se 'upega tafaʻilagi e auai i faʻataʻitaʻiga taʻitaʻia e soʻo se NCTN kulupu e faʻamaonia ai a latou tagata suʻesuʻe. O le mea lea, o tagata suʻesuʻe mai le LAPS, NCORP, isi nofoaga faʻaleaʻoaʻoga, faʻataʻitaʻiga a le nuʻu, ma sui faʻavaomalo e fesoʻotaʻi ma vaega a le Network, e ono aʻafia uma tagata mamaʻi i faʻamasinoga a le NCTN.

Ata ma le susulu Oncology Core Vaega (IROC)

Ina ia fesoasoani e vaʻavaʻaia ma faʻamautinoa le lelei i faʻataʻitaʻiga e aofia ai ni ata fou o faʻataʻitaʻiga ma / poʻo togafitiga o le radiation, na faʻatuina ai e le NCTN se Imaging and Radiation Oncology Core (IROC) GroupExit Disclaimer e fesoasoani i vaega uma a le NCTN o loʻo faʻaaogaina nei auala i latou tofotofoga.

Tuʻufaʻatasia o faʻailoga faʻasaienisi faʻasaienisi (ITSA)

O le vaega mulimuli o le NCTN o le Integrated Translational Science Awards (ITSAs). O aoga faʻaleaʻoaʻoga e lima na mauaina le ITSA e aofia ai vaega o saienitisi faʻaliliuga o loʻo faʻaaogaina tekonolosi fou, proteomic, ma faʻataʻitaʻiga ata e fesoasoani e faʻailoa ma agavaʻa ono mafai ona vaʻaiia biomarkers o tali atu i togafitiga e mafai ona tuʻufaʻatasia i totonu o faʻalapotopotoga vaega i lumanaʻi falemaʻi tofotofoga.

O nei faʻailoga o loʻo faʻaaogaina e faʻaaoga ai galuega ua amataina nei i totonu o fale suʻesuʻe a le au suʻesuʻe, e masani ona lagolagoina i se vaega e isi tupe foaʻi a le NCI, faatasi ai ma le manatu o le a fesoasoani nei tagata suʻesuʻe i vaega o fesoʻotaʻiga i le aumaia o mea fou i fale suesue i falemaʻi. O nei falefaigaluega o loʻo faʻaaogaina uma tekinolosi faʻaosofia e mafai ai ona sili atu le faʻamatalaina o tuma ma fesoasoani e faʻailoa ia suiga o le biology o le tuma i le tali atu i togafitiga e ono fesoasoani e faʻamatala pe faʻafefea ona tupu le teteʻeina o togafitiga.

O i latou e faʻatupeina le ITSA:

Falemai a Tamaiti o PhiladelphiaExit Disclaimer

Iunivesite Emory - Winship Cancer InstituteExit Disclaimer

Faʻamanatuga Sloan Kettering Cancer CenterExit Disclaimer

Iunivesete o le Setete o Ohio

Iunivesite o North Carolina Lineberger Comprehensive Cancer CenterExit Disclaimer

NCTN Faletupe Faletupe

O kulupu NCTN taʻitasi e aoina foʻi ma teuina aano mai tagata mamaʻi i le NCTN faʻataʻitaʻiga i se fesoʻotaʻiga fesoʻotaʻiga o sela o aano. O tulafono masani na atiaʻe e faʻamautinoa ai o le aotelega ua aoina e sili ona maualuga lona lelei. O faʻamaumauga faʻakomepiuta o loʻo teuina faʻataʻitaʻiga o loʻo iai faʻamatalaga taua o le falemaʻi, e pei o togafitiga na maua e tagata mamaʻi na aveina mai ai le tino, tali mai ma faʻaiuga o gasegase. Tagata auai i NCTN faʻataʻitaʻiga mafai foi ona faʻatagaina le faʻaaogaina o a latou aano faʻapitoa mo suʻesuʻega i tua atu o le NCTN faʻamasinoga na lesitalaina ai i latou. O le NCTN tinoitupe polokalama faletupe aofia ai se 'upega tafaʻilagi faiga e mafai e soʻo se suʻesuʻe ona faʻaaogaina. Tagata suʻesuʻe, e aofia ai ma i latou e le o fesoʻotaʻi ma le NCTN,

Komiti Vaai faasaienitisi

O vaega NCTN fuafuaina manatu mo fou falemaʻi tofotofoga i le NCI Faʻamaʻi / Imaging Steering Komiti. O nei komiti o loʻo faʻatulagaina e le NCI e iloilo ma faʻamuamua faʻataʻitaʻiga fou o falemaʻi ma fautuaina ia NCI i latou e foliga mai e iai le maualuga faʻasaienisi ma falemaʻi aʻafiaga. Taʻitasi komiti e taʻitaʻia e le malo-co-nofoa nofoa e le faʻatagaina e umia tulaga faʻataʻitaʻi i le NCTN kulupu, e ui lava e mafai ona avea ma sui o le kulupu. O totoe o le avea ma sui auai o le komiti e aofia ai sui o le vaega NCTN filifilia e vaega taʻitasi, isi faʻapitoa faʻamaʻi e le aofia ai i tulaga faʻataʻitaʻi i vaega, sui o NCI-faʻatupeina SPORE ma Consortia, biostatisticians, onosaʻi fautua, ma NCI faʻamaʻi faʻapitoa.

NCTN Paketi

O le aotelega o le paketi a le NCTN e $ 171 miliona, tufatufa atu i vaega eseese o le upega tafailagi. O lenei faiga e faʻaavanoaina mo le lesitalaina faaletausaga e tusa ma le 17,000-20,000 tagata auai i togafitiga o le kanesa ma ata faʻataʻitaʻi.

Malosiaga i le Galulue Faʻatasi

NCTN kulupu e mafai ona faʻaititia le tau o le faʻatautaia o faʻataʻitaʻiga e ala i le faʻasoaina o mea taua. O lenei faiga faʻatasi e faʻatagaina ai sui o le tasi NCTN kulupu e lagolago faʻataʻitaʻiga taʻitaʻia e isi kulupu ma mafai ai e sui o le NCTN ona faʻatautaia se atoaga o faʻataʻitaʻiga i kanesa masani.

Talu ai o le NCTN e naʻo le fa vaega a le au matutua a le Iunaite Setete, e toʻaititi le Aʻoga ma Fuainumera Faʻamaumauga e manaʻomia ai le lagolago tautupe, ua i ai le sefe taugofie. O kulupu uma latou te faʻaaogaina se faʻamatalaga masani e faʻatautaia ai faʻamaumauga (Medidata Rave) ma se polokalame tuʻufaʻatasia o IT mo faletupe, o lona uiga e sefe ai tau.

Lagolago Faʻaopopo

Togafitiga faʻafomaʻi e faigata gaioiga e manaʻomia ai le tele o faʻalapotopotoga lagolago ma faʻatupeina vaitafe. O le fesoʻotaʻiga e aofia ai le tele o isi foliga e le o aofia i le NCTN faʻailoga ae e taua i le faʻatinoina o le NCTN misiona.

O le lagolago faʻaopopo aofia ai:

• Central Institutional Review Boards, o se vaega taua o le NCI's clinical trial system e faʻaopopo ai le saoasaoa, lelei, ma le laugatasia o le amio lelei iloiloina.

• O le Cancer Trials Support Unit (CTSU), o se konekarate na faʻatupeina e le NCI e maua ai tagata sailiili falemaʻi ma a latou aufaigaluega ma le tasi-taofi avanoa i luga o le upega tafailagi i le NCTN faʻataʻitaʻiga ma faʻatagaina ai tagata suʻesuʻe e lesitalaina tagata fou.

• O se tuʻufaʻatasia o tinoitupe faletupe mo kulupu taʻitasi ua faʻatupeina e ala i le tuʻu eseʻese NCI faʻailoga auala.

• O le Biomarker, Imaging, ma le Quality of Life Studies Fund Fund (BIQSFP), o se eseʻese faʻatupeina vaitafe mo NCTN faʻataʻitaʻiga e lagolagoina faʻamaonia saienisi suʻesuʻega i kulupu suʻega. NCTN kulupu tauva mo tupe e faʻapitoa faʻapolopoloina tausaga uma mo lenei faʻamoemoe. O le mauaina o faʻapitoa tupe faʻafaigofie faʻafaigofieina faʻamaopoopoina, e pei o falemaʻi tofotofoga tatau ona ausia faʻatapulaʻaina aso faʻatulagaina.

• I se faʻaopopoga, tusa o le tasi kuata o le faʻamautuina o le onosaʻi i luga o le NCTN faʻataʻitaʻiga togafitiga e totogiina e le polokalame NCORP. O falemaʻi ma falemaʻi o loʻo aʻafia i le polokalame a le NCORP ua toe faʻafoʻi atu mo le faʻailoaina o tagata mamaʻi i le NCTN faʻataʻitaʻiga togafitiga e ala ia latou faʻailoga NCORP, e le ala i le faʻailoga o le NCTN Group Operations.

I le iuga, i le faʻaopopoina i nei tele tupe faʻaalu faaletausaga, NCI faʻapea foi ona faʻasoasoaina le NCTN e ala i le totogiina mo le tele o isi mea taua falemaʻi faʻataʻitaʻiga galuega, ma atili ai le faʻaititia o tau aveina e le Network vaega:

• E totogi e le NCI laisene ma talimalo totogi o le eletise, masani faʻatonutonu faʻamaumauga faiga, taʻua o le Medidata Rave, faʻaaogaina e vaega uma o le NCTN.

• NCI vaʻavaʻaia se atunuʻu suʻetusi faiga mo NCTN faʻataʻitaʻiga.

• O loʻo faʻatautaia e le NCI le suʻesuʻeina o ni vailaʻau fou i le Food and Drug Administration faʻatasi ai ma le tufatufaina o nei vailaʻau mo le tele o faʻataʻitaʻiga o le NCTN.

O le felagolagomaʻi i totonu o kulupu e vaʻaia e taua tele i le manuia i faʻalapotopotoga uma ma ua faʻamanuiaina faʻapitoa lava i le taimi o le fesoasoani tupe. Lelei tele o loʻo faʻamamafaina foi, ma faʻamalosia taimi faʻatulagaina ua i ai nei mo le fausiaina maliega. E ui lava o nei suiga e taua tele mo le soifua maloloina o le lautele, ae na oʻo mai foi i se taimi talafeagai, aua o suiga matagofie i le oncologic science o loʻo ofaina mai ai ni auala fou mo ni alualu i luma vave, aemaise lava mo le atinaʻeina o ni togafitiga fou.