Types/soft-tissue-sarcoma/patient/child-soft-tissue-treatment-pdq

Ubwana Bworoheje Tissue Sarcoma Kuvura (®) –Umurwayi

Amakuru Rusange Yerekeye Ubwana Tissue Yoroheje Sarcoma

INGINGO Z'INGENZI

• Ubwana bworoheje tissue sarcoma ni indwara aho ingirabuzimafatizo mbi (kanseri) zikora mubice byoroshye byumubiri.

• Sarkoma yoroheje ibaho mubana ndetse nabakuze.

• Kugira indwara zimwe na zimwe zirazwe zirashobora kongera ibyago byo kuba bwana tissue sarcoma.

• Ikimenyetso gikunze kugaragara mu bwana bworoshye tissue sarcoma ni ibibyimba bitababaza cyangwa kubyimba mubice byoroshye byumubiri.

• Ibizamini byo gusuzuma bikoreshwa mugushakisha (gushakisha) no gusuzuma sarcoma yoroheje yo mu bwana.

• Niba ibizamini byerekana ko hashobora kubaho sarcoma yoroheje, biopsy irakorwa.

• Hariho ubwoko bwinshi butandukanye bwimitsi ya sarcomas.

• Ibibyimba by'amavuta

• Ibibyimba by'amagufwa na karitsiye

• Ibibyimba bya fibrous (ihuza)

• Ibibyimba by'imitsi

• Ibibyimba byimitsi byoroshye

• Ibyo bita ibibyimba bya fibrohistiocytic

• Ibibyimba byo mu mitsi

• Ibibyimba bya Pericyitike (Perivascular)

• Ibibyimba bituruka mu ngirabuzimafatizo

• Ibibyimba by'amaraso

• Ibintu bimwe bigira ingaruka kubitekerezo (amahirwe yo gukira) hamwe nuburyo bwo kuvura.

Ubwana bworoheje tissue sarcoma ni indwara aho ingirabuzimafatizo mbi (kanseri) zikora mubice byoroshye byumubiri.

Uturemangingo tworoheje twumubiri duhuza, dushyigikire, kandi tuzengurutse ibindi bice byumubiri ningingo. Tissue yoroshye harimo ibi bikurikira:

• Ibinure.

• Uruvange rw'amagufwa na karitsiye.

• Fibrous tissue.

• Imitsi.

• Imitsi.

• Tendons (imirongo ya tissue ihuza imitsi n'amagufwa).

• Uturemangingo twa synovial (tissue zikikije ingingo).

• Imiyoboro y'amaraso.

• Imiyoboro ya Lymph.

Tissue tissue sarcoma irashobora kuboneka ahantu hose mumubiri. Mu bana, ibibyimba bibaho cyane mumaboko, amaguru, igituza, cyangwa inda.

Sarkoma yoroheje yoroheje ikora mubice byoroshye byumubiri, harimo imitsi, imitsi, ibinure, imiyoboro yamaraso, imiyoboro ya lymph, imitsi, hamwe nuduce dukikije ingingo.

Sarkoma yoroheje ibaho mubana ndetse nabakuze.

Sarcoma yoroheje yumubiri mubana irashobora kwitabira ukundi kuvura, kandi irashobora kugira prognoza nziza kuruta sarcoma yoroheje ya tissue mubantu bakuru. .

Kugira indwara zimwe na zimwe zirazwe zirashobora kongera ibyago byo kuba bwana tissue sarcoma.

Ikintu cyose cyongera ibyago byo kwandura byitwa impanuka. Kugira ibintu bishobora guteza ibyago ntibisobanura ko uzarwara kanseri; kutagira ibyago bishobora gusobanura ko utazarwara kanseri. Vugana na muganga wumwana wawe niba utekereza ko umwana wawe ashobora guhura nibibazo.

Impamvu zishobora gutera ubwonko bworoheje bwana sarcoma harimo kugira ibibazo bikurikira byarazwe:

• Indwara ya Li-Fraumeni.

• Umuryango wa adenomatous polypose (FAP).

• RB1 ihinduka.

• SMARCB1 (INI1) ihinduka rya gen.

• Neurofibromatose ubwoko bwa 1 (NF1).

• Indwara ya Werner.

• Indwara ya sclerose.

• Adenosine deaminase-ibuze cyane immunodeficiency.

Ibindi bintu bishobora guteza ingaruka zirimo ibi bikurikira:

• Ubuvuzi bwashize hamwe no kuvura imirasire.

• Kugira sida (syndrome de syndrome de immunite) hamwe na virusi ya Epstein-Barr icyarimwe.

Ikimenyetso gikunze kugaragara mu bwana bworoshye tissue sarcoma ni ibibyimba bitababaza cyangwa kubyimba mubice byoroshye byumubiri.

Sarcoma irashobora kugaragara nkibibyimba bitababaza munsi yuruhu, akenshi kumaboko, ukuguru, igituza, cyangwa inda. Ntabwo hashobora kubaho ikindi kimenyetso cyangwa ibimenyetso mbere. Iyo sarcoma ikuze kandi igakanda ku ngingo zegeranye, imitsi, imitsi, cyangwa imiyoboro y'amaraso, birashobora gutera ibimenyetso cyangwa ibimenyetso, nk'ububabare cyangwa intege nke.

Ibindi bintu bishobora gutera ibimenyetso nibimenyetso bimwe. Menyesha umuganga wumwana wawe niba umwana wawe afite ibibazo.

Ibizamini byo gusuzuma bikoreshwa mugushakisha (gushakisha) no gusuzuma sarcoma yoroheje yo mu bwana.

Ibizamini hamwe nuburyo bukurikira birashobora gukoreshwa:

• Ikizamini cyumubiri namateka: Ikizamini cyumubiri kugirango ugenzure ibimenyetso rusange byubuzima, harimo no gusuzuma ibimenyetso byindwara, nkibibyimba cyangwa ikindi kintu cyose gisa nkidasanzwe. Hazafatwa kandi amateka yubuzima bwumurwayi nindwara zashize hamwe nubuvuzi.

• X-imirasire: X-ray ni ubwoko bwingufu zishobora kunyura mumubiri kuri firime, bigakora amashusho yibice byumubiri.

• MRI . Ubu buryo bwitwa kandi magnetic magnetic resonance imaging (NMRI).

Magnetic resonance imaging (MRI) yinda. Umwana aryamye kumeza anyerera muri scaneri ya MRI, ifata amashusho imbere yumubiri. Urupapuro ku nda yumwana rufasha gukora amashusho neza.

• CT scan (CAT scan): Uburyo bukora urukurikirane rwamashusho arambuye yibice byimbere mumubiri, nkigituza cyangwa inda, byafashwe muburyo butandukanye. Amashusho yakozwe na mudasobwa ihujwe na mashini ya x-ray. Irangi rishobora guterwa mumitsi cyangwa kumirwa kugirango bifashe ingingo cyangwa ingirangingo kugaragara neza. Ubu buryo nabwo bwitwa computing tomografiya, tomografiya ya mudasobwa, cyangwa mudasobwa ya axial tomografiya.

Kubara tomografiya (CT) scan yinda. Umwana aryamye kumeza anyerera muri CT scaneri, ifata amashusho ya x-ray imbere yinda.

• Ikizamini cya Ultrasound: Uburyo bukoreshwa mu majwi menshi y’amajwi (ultrasound) asohoka mu ngingo cyangwa mu ngingo imbere hanyuma agasubiramo. Ijwi ryerekana ishusho yumubiri wumubiri witwa sonogram. Ishusho irashobora gucapurwa kugirango irebe nyuma.

Niba ibizamini byerekana ko hashobora kubaho sarcoma yoroheje, biopsy irakorwa.

Ubwoko bwa biopsy buterwa, igice, nubunini bwa misa kandi niba ari hafi yubuso bwuruhu cyangwa byimbitse mubice. Bumwe mu bwoko bukurikira bwa biopsies bukoreshwa:

• Biopsy yibanze: Gukuraho tissue ukoresheje urushinge runini. Hafashwe ingero nyinshi. Ubu buryo bushobora kuyoborwa hakoreshejwe ultrasound, CT scan, cyangwa MRI.

• Biopsy incisional: Gukuraho igice cyikibyimba cyangwa icyitegererezo cyumubiri.

• Biopsy idasanzwe: Gukuraho ibibyimba byose cyangwa agace ka tissue bidasa nkibisanzwe. Inzobere mu bijyanye n’indwara ireba ingirangingo ziri munsi ya microscope kugira ngo ishakishe kanseri. Biopsy idasanzwe irashobora gukoreshwa mugukuraho burundu ibibyimba bito biri hafi yuruhu. Ubu bwoko bwa biopsy ntibukoreshwa gake kuko selile za kanseri zishobora kuguma nyuma ya biopsy. Niba kanseri igumye, kanseri irashobora kugaruka cyangwa irashobora gukwirakwira mu bindi bice byumubiri.

MRI y'ikibyimba ikorwa mbere ya biopsy idasanzwe. Ibi bikorwa kugirango berekane aho ikibyimba cyumwimerere cyakorewe kandi gishobora gukoreshwa mu kuyobora kubaga ejo hazaza cyangwa kuvura imirasire.

Niba bishoboka, umuganga uzakuraho ikibyimba cyose kiboneka agomba kugira uruhare mugutegura biopsy. Gushyira inshinge cyangwa ibice bya biopsy birashobora kugira ingaruka niba ikibyimba cyose gishobora kuvaho mugihe cyo kubagwa nyuma.

Kugirango utegure uburyo bwiza bwo kuvura, icyitegererezo cya tissue cyakuweho mugihe cya biopsy kigomba kuba kinini bihagije kugirango umenye ubwoko bwa tissue tissue sarcoma kandi ukore ibindi bizamini bya laboratoire. Ingero za tissue zizakurwa mubyimba byambere, lymph node, nahandi hantu hashobora kuba kanseri ya kanseri. Inzobere mu bijyanye n’indwara ireba ingirangingo ziri munsi ya microscope kugira ngo ishakishe kanseri ya kanseri no kumenya ubwoko n'ikibyimba. Urwego rw'ikibyimba rushingiye ku kuntu ingirabuzimafatizo za kanseri zidasanzwe zisa munsi ya microscope ndetse n'ingirabuzimafatizo zigabanuka vuba. Ibibyimba byo mu rwego rwo hejuru no hagati yo hagati bikunze gukura no gukwirakwira vuba kuruta ibibyimba byo hasi.

Kuberako sarcoma yoroheje yoroheje ishobora kugorana kuyisuzuma, icyitegererezo cyumubiri kigomba kugenzurwa numu psychologue ufite uburambe mugupima sarcoma yoroheje.

Kimwe cyangwa byinshi mubizamini bya laboratoire bikurikira birashobora gukorwa kugirango bige ingero za tissue:

• Ikizamini cya molekuline: Ikizamini cya laboratoire kugirango harebwe genes zimwe na zimwe, poroteyine, cyangwa izindi molekile mu cyitegererezo cya tissue, maraso, cyangwa andi mazi yo mu mubiri. Ikizamini cya molekile gishobora gukorwa nubundi buryo, nka biopsies, kugirango bifashe gusuzuma ubwoko bumwe na bumwe bwa kanseri. Ibizamini bya molekuline bigenzura gene zimwe na zimwe za chromosome zigaragara muri sarcomas yoroheje.

• Ikizamini cya transcription - polymerase urunani (RT - PCR) ikizamini: Ikizamini cya laboratoire gipimwa ingano yibintu bikomoka ku ngirabuzima fatizo bita mRNA yakozwe na gene runaka. Enzyme yitwa reverse transcriptase ikoreshwa muguhindura igice runaka cya RNA mukigice cya ADN gihuye, gishobora kongerwa (cyakozwe mubwinshi) nindi misemburo yitwa ADN polymerase. Kopi ya ADN yongerewe ifasha kumenya niba mRNA yihariye ikorwa na gene. RT - PCR irashobora gukoreshwa mugusuzuma imikorere ya genes zimwe na zimwe zishobora kwerekana ko hari kanseri ya kanseri. Iki kizamini gishobora gukoreshwa mugushakisha impinduka zimwe na zimwe muri gen cyangwa chromosome, zishobora gufasha gusuzuma kanseri.

• Isesengura rya Cytogenetike: Ikizamini cya laboratoire kibarwa chromosomes ya selile mucyitegererezo cyama tissue yibibyimba ikanagenzurwa niba hari impinduka, nko kuvunika, kubura, gutondekanya, cyangwa chromosomes ziyongera. Impinduka muri chromosomes zimwe zishobora kuba ikimenyetso cya kanseri. Isesengura rya Cytogenetike rikoreshwa mu gufasha gusuzuma kanseri, gutegura gahunda yo kuvura, cyangwa kumenya uburyo ubuvuzi bukora neza. Fluorescence muburyo bwo kuvanga (FISH) ni ubwoko bwisesengura rya cytogenetike.

• Immunocytochemie: Ikizamini cya laboratoire ikoresha antibodies kugirango igenzure antigene zimwe na zimwe (marikeri) mu cyitegererezo cy'uturemangingo tw'umurwayi. Antibodies zisanzwe zifitanye isano na enzyme cyangwa irangi rya fluorescent. Antibodies zimaze guhuza na antigen murugero rwingirabuzimafatizo z'umurwayi, enzyme cyangwa irangi birakorwa, hanyuma antigen irashobora kuboneka munsi ya microscope. Ubu bwoko bwikizamini bushobora gukoreshwa kugirango tumenye itandukaniro riri hagati yubwoko butandukanye bwimitsi ya sarcoma.

• Mikorosikopi yumucyo na electron: Ikizamini cya laboratoire aho selile ziri murugero rwa tissue zirebwa munsi ya microscopes isanzwe kandi ifite imbaraga nyinshi kugirango ishakishe impinduka zimwe na zimwe.

Hariho ubwoko bwinshi butandukanye bwimitsi ya sarcomas.

Ingirabuzimafatizo za buri bwoko bwa sarcoma zisa zitandukanye munsi ya microscope. Ibibyimba byoroheje byumubiri bishyizwe hamwe hashingiwe ku bwoko bwa selile yoroheje aho byatangiriye bwa mbere.

Iyi ncamake yerekeye ubwoko bukurikira bwa tissue tissue sarcoma:

Ibibyimba by'amavuta

Liposarcoma. Iyi ni kanseri ya selile. Liposarcoma mubisanzwe ikora ibinure munsi yuruhu. Mu bana n'ingimbi, liposarcoma ikunze kuba murwego rwo hasi (birashoboka gukura no gukwirakwira buhoro). Hariho ubwoko butandukanye bwa liposarcoma, harimo:

• Myxoid liposarcoma. Ubusanzwe iyi ni kanseri yo mu rwego rwo hasi yitabira kuvura.

• Pleomorphic liposarcoma. Ubusanzwe iyi ni kanseri yo mu rwego rwo hejuru idashobora kwitabira neza kuvurwa.

Ibibyimba by'amagufwa na karitsiye

Ibibyimba by'amagufa na karitsiye ni uruvange rw'utugingo ngengabuzima hamwe na selile. Ibibyimba by'amagufa na karitsiye birimo ubwoko bukurikira:

• Extraskeletal mesenchymal chondrosarcoma. Ubu bwoko bwamagufwa na karitsiye yibasira abakiri bato kandi bibaho mumutwe no mumajosi.

• Osteosarcoma idasanzwe. Ubu bwoko bw'ikibyimba n'amagufwa ni gake cyane mubana ndetse ningimbi. Birashoboka ko azagaruka nyuma yo kuvurwa kandi ashobora gukwira mu bihaha.

Ibibyimba bya fibrous (ihuza)

Ibibyimba bya fibre (bihuza) birimo ubwoko bukurikira:

• Ubwoko bwa fibromatose ya Desmoid (nanone bita desmoid tumor cyangwa fibromatose yibasira). Iki kibyimba cya fibrous tissue kiri murwego rwo hasi (birashoboka gukura buhoro). Irashobora kugaruka mubice byegeranye ariko mubisanzwe ntibikwirakwira mubice bya kure byumubiri. Rimwe na rimwe, fibromatose yo mu bwoko bwa desmoid irashobora guhagarika gukura igihe kirekire. Ni gake, ikibyimba gishobora gucika nta kuvura.

Ibibyimba bya Desmoid rimwe na rimwe bibaho mubana bafite impinduka muri gene ya APC. Impinduka muri iyi gen irashobora kandi gutera umuryango wa adenomatous polypose (FAP). FAP ni imiterere yarazwe (yandujwe n'ababyeyi ikomoka ku rubyaro) aho polyps nyinshi (imikurire ku myanya ndangagitsina) zikora ku rukuta rw'imbere rw'imbere na rectum. Ubujyanama bwa genetike (ikiganiro numuhanga wabihuguriwe kubyerekeye indwara twarazwe hamwe nuburyo bwo gupima gene) birashobora gukenerwa.

• Dermatofibrosarcoma protuberans. Iki ni ikibyimba cyibice byimbitse byuruhu bikunze kugaragara mumitiba, amaboko, cyangwa amaguru. Ingirabuzimafatizo z'iki kibyimba zifite impinduka zimwe na zimwe zitwa translocation (igice cya gene COL1A1 ihindura ahantu hamwe na gene ya PDGFRB). Kugirango umenye dermatofibrosarcoma protuberans, selile yibibyimba irasuzumwa kugirango ihindurwe. Dermatofibrosarcoma protuberans mubisanzwe ntabwo ikwirakwira kuri lymph node cyangwa ibindi bice byumubiri.

• Ikibyimba cya myofibroblastique. Iyi kanseri igizwe n'ingirangingo z'imitsi, ingirabuzimafatizo zihuza, hamwe na selile zimwe na zimwe z'umubiri. Bibaho mu bana n'ingimbi. Akenshi ikora mubice byoroshye, ibihaha, impyiko, namabere. Iragaruka kenshi nyuma yo kuvurwa ariko gake ikwirakwira mubice bya kure byumubiri. Impinduka zishingiye ku ngirabuzima fatizo zabonetse hafi kimwe cya kabiri cy’ibibyimba.

Fibrosarcoma.

Hariho ubwoko bubiri bwa fibrosarcoma mubana ningimbi:

• Fibrosarcoma y'uruhinja (nanone yitwa fibrosarcoma ivuka). Ubu bwoko bwa fibrosarcoma busanzwe buboneka kubana bafite umwaka 1 nuwuto kandi birashobora kugaragara mubizamini bya ultrasound mbere yo kubyara. Iki kibyimba kirakura vuba kandi akenshi ni kinini mugupima. Ntibikunze gukwirakwira mu bice bya kure byumubiri. Ingirabuzimafatizo z'iki kibyimba zisanzwe zigira ihinduka ryihariye ryitwa translocation (igice cya chromosome imwe ihindura ahantu hamwe nikindi gice cya chromosome). Kugirango hamenyekane fibrosarcoma yibana, selile yibibyimba isuzumwa kugirango iyi mpinduka ihindurwe. Ikibyimba gisa nacyo cyagaragaye mubana bakuze, ariko ntigifite ubusobanuro bukunze kugaragara mubana bato.

• Fibrosarcoma ikuze. Ubu ni ubwoko bumwe bwa fibrosarcoma iboneka mubantu bakuru. Ingirabuzimafatizo z'iki kibyimba ntizifite ihinduka ry'ingirabuzima fatizo ziboneka muri fibrosarcoma. (Reba incamake ya kubuvuzi bukuze bworoshye Tissue Sarcoma kubindi bisobanuro.)

• Myxofibrosarcoma. Iki ni ikibyimba kidasanzwe cya fibrous tissue kibaho gake cyane kubana kurusha abakuze.

• Fibromyxoid yo mu rwego rwo hasi. Iki ni ikibyimba gikura buhoro buhoro kigaragara cyane mumaboko cyangwa amaguru kandi ahanini kigira ingaruka kubakuze bato n'abakuru. Ikibyimba gishobora kugaruka nyuma yimyaka myinshi nyuma yo kuvurwa kigakwira mu bihaha no ku rukuta rw'igituza. Gukurikirana ubuzima bwawe bwose birakenewe.

• Sclerose epithelioid fibrosarcoma. Iki nikibyimba kidasanzwe cya fibrous tissue gikura vuba. Irashobora kugaruka no gukwirakwira mubindi bice byumubiri nyuma yimyaka yo kuvurwa. Gukurikirana igihe kirekire birakenewe.

Ibibyimba by'imitsi

Imitsi ya skeletale ifatanye namagufwa kandi ifasha umubiri kugenda.

• Rhabdomyosarcoma. Rhabdomyosarcoma nigisanzwe cyabana bato cyoroshye tissue sarcoma mubana bafite imyaka 14 nabato. (Reba incamake ya kubuvuzi bwabana Rhabdomyosarcoma kubindi bisobanuro.)

Ibibyimba byimitsi byoroshye

Imitsi yoroshye neza imbere yimiyoboro yamaraso ningingo zimbere zifunguye nkigifu, amara, uruhago, na nyababyeyi.

• Leiomyosarcoma. Iki kibyimba cyimitsi cyoroheje cyahujwe na virusi ya Epstein-Barr mubana nabo banduye virusi itera sida. Leiomyosarcoma irashobora kandi kuba kanseri ya kabiri ku barokotse retinoblastoma yarazwe, rimwe na rimwe nyuma yimyaka myinshi nyuma yo kuvurwa bwa mbere kuri retinoblastoma.

Ibyo bita ibibyimba bya fibrohistiocytic

• Plexiform fibrohistiocytic ikibyimba. Iki ni ikibyimba kidasanzwe gikunze kwibasira abana ndetse nabakuze. Ikibyimba gikunze gutangira nkikura ridafite ububabare hejuru cyangwa munsi yuruhu kumaboko, kuboko, cyangwa kuboko. Ntibishobora gukwirakwira hafi ya lymph node cyangwa ibihaha.

Ibibyimba byo mu mitsi

Icyatsi cya nervice kigizwe nuburinzi bwa myelin butwikiriye ingirabuzimafatizo zitari mu bwonko cyangwa uruti rw'umugongo. Ibibyimba byo mu mitsi birimo ubwoko bukurikira:

• Malignant peripheral nerv sheath tumor. Bamwe mu bana bafite ibibyimba bibi bya periferique nervice sheath tumor bafite imiterere idasanzwe ya genetike yitwa neurofibromatose ubwoko bwa 1 (NF1). Iki kibyimba gishobora kuba kiri hasi cyangwa murwego rwo hejuru.

• Ikibyimba cya Triton . Ibi nibibyimba bikura cyane bibaho cyane kubana bafite NF1.

• Ectomesenchymoma. Iki nikibyimba gikura vuba kibaho cyane cyane kubana. Ectomesenchymoma irashobora gukora mumaso yijisho, inda, amaboko, cyangwa amaguru.

Ibibyimba bya Pericyitike (Perivascular)

Ibibyimba bya Pericyitike bibumbira mu ngirabuzimafatizo zizingira mu mitsi. Ibibyimba bya Pericytike birimo ubwoko bukurikira:

• Myopericytoma. Infantile hemangiopericytoma ni ubwoko bwa myopericytoma. Abana barengeje umwaka 1 mugihe cyo kwisuzumisha barashobora kugira prognoza nziza. Ku barwayi barengeje umwaka, hemangiopericytoma y'abana ikunze gukwirakwira mu bindi bice by'umubiri, harimo na lymph node n'ibihaha.

• Infantile myofibromatose. Infantile myofibromatose nubundi bwoko bwa myopericytoma. Nibibyimba bya fibrous bikunze kubaho mumyaka 2 yambere yubuzima. Hashobora kubaho node imwe munsi yuruhu, mubisanzwe mumutwe no mumajosi (myofibroma), cyangwa nodules nyinshi muruhu, imitsi, cyangwa amagufwa (myofibromatose). Ku barwayi barwaye myofibromatose, kanseri irashobora no gukwirakwira mu ngingo. Ibi bibyimba birashobora kugenda bitavuwe.

Ibibyimba bituruka mu ngirabuzimafatizo

Ibibyimba bituruka mu ngirabuzimafatizo zitazwi (ubwoko bw'uturemangingo ikibyimba cyatangiye kubaho mbere ntabwo kizwi) harimo ubwoko bukurikira:

• Sarovoma. Synovial sarcoma ni ubwoko busanzwe bwa tissue sarcoma yoroshye mubana ndetse ningimbi. Ubusanzwe ikora mumyanya ikikije ingingo mumaboko cyangwa amaguru, ariko irashobora no kuboneka mumitwe, mumutwe, cyangwa ijosi. Utugingo ngengabuzima tw'iki kibyimba ubusanzwe dufite impinduka zishingiye ku ngirabuzima fatizo zitwa guhinduranya (igice cya chromosome imwe ihindura ahantu hamwe n'igice cya chromosome). Ibibyimba binini bifite ibyago byinshi byo gukwirakwira mu bindi bice byumubiri, harimo ibihaha. Abana barengeje imyaka 10 bafite ikibyimba gifite santimetero 5 cyangwa ntoya kandi kikaba cyarakozwe mumaboko cyangwa amaguru bafite prognoza nziza.

• Epithelioid sarcoma. Iyi ni sarcoma idasanzwe isanzwe itangira cyane mubice byoroheje nkikura buhoro, ikibyimba gikomeye kandi gishobora gukwirakwira kuri lymph node. Niba kanseri yibumbiye mumaboko, amaguru, cyangwa ikibuno, hashobora gukorwa sentinel lymph node biopsy kugirango isuzume kanseri mumitsi.

• Alveolar yoroshye igice sarcoma. Iki nikibyimba kidasanzwe cyumubiri woroshye uhuza ukazenguruka ingingo nizindi ngingo. Bikunze kugaragara mumaboko n'amaguru ariko birashobora kugaragara mubice byiminwa, urwasaya, no mumaso. Irashobora gukura buhoro kandi ikwirakwira mubindi bice byumubiri. Alveolar yoroshye igice sarcoma irashobora kugira prognoza nziza mugihe ikibyimba gifite santimetero 5 cyangwa ntoya cyangwa mugihe ikibyimba kivanyweho burundu no kubagwa. Ingirabuzimafatizo z'iki kibyimba zisanzwe zigira ihinduka ryihariye ryitwa translocation (igice cya gene ASSPL ihindura ahantu hamwe na gen ya TFE3). Kugirango umenye alveolar yoroshye igice sarcoma, selile yibibyimba irasuzumwa kugirango ihindurwe.

• Kuraho selile sarcoma ya tissue yoroshye. Iki nikibyimba gikura buhoro buhoro ikibyimba gitangirira mumitsi (ikomeye, fibrous, umugozi umeze nkumugozi uhuza imitsi kumagufa cyangwa ikindi gice cyumubiri). Sarcoma isukuye ikunze kugaragara mubice byimbitse byikirenge, agatsinsino, nibirenge. Irashobora gukwirakwira hafi ya lymph node. Ingirabuzimafatizo z'iki kibyimba ubusanzwe zigira impinduka zimwe na zimwe zitwa translocation (igice cya gene ya EWSR1 ihindura ahantu hamwe na ATF1 cyangwa CREB1). Kugirango umenye selile sarcoma isobanutse yumubiri woroshye, selile yibibyimba irasuzumwa kugirango iyi mpinduka ihindurwe.

• Extraskeletal myxoid chondrosarcoma. Ubu bwoko bwa tissue tissue sarcoma irashobora kugaragara mubana ningimbi. Igihe kirenze, gikunda gukwirakwira mubindi bice byumubiri, harimo nindimu n ibihaha. Ikibyimba gishobora kugaruka nyuma yimyaka myinshi nyuma yo kuvurwa.

• Extraskeletal Ewing sarcoma. Reba incamake ya kubijyanye no kuvura Ewing Sarcoma kumakuru.

• Desmoplastique ntoya yibibyimba. Iki kibyimba gikunze kuboneka muri peritoneum munda, munda, na / cyangwa peritoneum muri scrotum, ariko irashobora kwibumbira mumpyiko cyangwa izindi ngingo zikomeye. Ibibyimba bito byinshi bishobora kugaragara muri peritoneum. Ikibyimba gito cya Desmoplastique gishobora no gukwirakwira mu bihaha no mu bindi bice byumubiri. Utugingo ngengabuzima tw'iki kibyimba ubusanzwe dufite impinduka zishingiye ku ngirabuzima fatizo zitwa guhinduranya (igice cya chromosome imwe ihindura ahantu hamwe n'igice cya chromosome). Kugirango umenye desmoplastique ntoya yibibyimba, selile yibibyimba birasuzumwa kugirango ihindurwe.

• Ikibyimba kidasanzwe (extracranial) rhabdoid ikibyimba. Iki kibyimba gikura vuba kigaragara mubice byoroshye nk'umwijima n'uruhago. Ubusanzwe iboneka mubana bato, harimo n'impinja, ariko irashobora kugaragara mubana bakuru ndetse nabakuze. Ibibyimba bya Rhabdoid birashobora kuba bifitanye isano no guhindura gene suppressor gene yitwa SMARCB1. Ubu bwoko bwa gene bukora poroteyine ifasha kugenzura imikurire ya selile. Impinduka muri gene ya SMARCB1 irashobora kuragwa. Ubujyanama bwa genetike (ikiganiro ninzobere yabihuguriwe kubyerekeye indwara twarazwe kandi birashoboka ko hakenewe kwipimisha gene).

• Ibibyimba byo mu bwoko bwa epithelioid selile (PEComa). Benign PEComa irashobora kugaragara mubana bafite imiterere yarazwe yitwa tuberous sclerose. Bibaho mu gifu, mu mara, mu bihaha, no mu myanya ndangagitsina. PECOMA ikura buhoro kandi benshi ntibashobora gukwirakwira.

• Sarcoma idatandukanijwe / idafite urutonde. Ibibyimba mubisanzwe bibaho mumagufwa cyangwa imitsi ifatanye namagufwa kandi ifasha umubiri kugenda.

• Udasobanutse neza pleomorphic sarcoma / malignant fibrous histiocytoma (urwego rwo hejuru). Ubu bwoko bwikibyimba cyoroshye gishobora kwibumbira mubice byumubiri aho abarwayi bahawe imiti ivura imirasire, cyangwa nka kanseri ya kabiri kubana barwaye retinoblastoma. Ikibyimba gikunze kuboneka mumaboko cyangwa amaguru kandi gishobora gukwirakwira mubindi bice byumubiri. (Reba incamake ya kuri Osteosarcoma na Malignant Fibrous Histiocytoma yo kuvura amagufwa kugirango umenye amakuru yerekeye fibrous histrousocytoma yamagufwa.)

Ibibyimba by'amaraso

Ibibyimba by'amaraso birimo ubwoko bukurikira:

• Epithelioid hemangioendothelioma. Epithelioid hemangioendothelioma irashobora kugaragara mubana ariko ikunze kugaragara mubantu bakuru bafite hagati yimyaka 30 na 50. Ubusanzwe bibaho mu mwijima, mu bihaha, cyangwa mu magufa. Bashobora kuba bakura vuba cyangwa gukura buhoro. Hafi ya kimwe cya gatatu cyimanza, ikibyimba gikwirakwira mubindi bice byumubiri byihuse. (Reba incamake ya kubijyanye no kuvura ibibyimba byo mu bwana bwabana kugirango ubone ibisobanuro byinshi.)

• Angiosarcoma yumubiri woroshye. Angiosarcoma yumubiri woroshye ni ikibyimba gikura vuba kigaragara mumitsi yamaraso cyangwa imiyoboro ya lymph mubice byose byumubiri. Angiosarcomas nyinshi ziri cyangwa munsi yuruhu. Abari mubice byimbitse byoroshye barashobora gukora mwumwijima, mu gihaha, cyangwa mu bihaha. Ntibisanzwe cyane mubana, rimwe na rimwe bakagira ibibyimba birenze uruhu cyangwa umwijima. Ni gake, hemangioma yibana irashobora guhinduka angiosarcoma yumubiri woroshye. (Reba incamake ya kubijyanye no kuvura ibibyimba byo mu bwana bwabana kugirango ubone ibisobanuro byinshi.)

Reba incamake ya ikurikira kumakuru yubwoko bworoshye tissue sarcoma itashyizwe muriyi ncamake:

• Umwana Rhabdomyosarcoma

• Ewing Sarcoma

• Osteosarcoma na Malignant Fibrous Histiocytoma yo kuvura amagufwa

• Kanseri idasanzwe yo kuvura abana (ibibyimba bya gastrointestinal)

Ibintu bimwe bigira ingaruka kubitekerezo (amahirwe yo gukira) hamwe nuburyo bwo kuvura.

Kumenyekanisha (amahirwe yo gukira) hamwe nuburyo bwo kuvura biterwa nibi bikurikira:

• Igice cyumubiri aho ikibyimba cyatangiye.

• Ingano nu ntera yikibyimba.

• Ubwoko bwa tissue yoroshye sarcoma.

• Ukuntu ikibyimba cyimbitse munsi yuruhu.

• Niba ikibyimba cyakwirakwiriye ahandi mu mubiri n'aho cyakwirakwiriye.

• Umubare wibibyimba bisigaye nyuma yo kubagwa kugirango ubikureho.

• Niba imiti ivura imirasire yakoreshejwe mu kuvura ikibyimba.

• Niba kanseri imaze gupimwa cyangwa yagarutse (garuka).

Ibyiciro by'Ubwana Byoroheje Tissue Sarcoma

INGINGO Z'INGENZI

• Nyuma yo kwisuzumisha mu bwana bworoheje tissue sarcoma, hakorwa ibizamini kugirango hamenyekane niba selile kanseri yakwirakwiriye mu bindi bice byumubiri.

• Hariho uburyo butatu kanseri ikwirakwira mu mubiri.

• Kanseri irashobora gukwirakwira aho yatangiriye no mu bindi bice byumubiri.

Nyuma yo kwisuzumisha mu bwana bworoheje tissue sarcoma, hakorwa ibizamini kugirango hamenyekane niba selile kanseri yakwirakwiriye mu bindi bice byumubiri.

Inzira ikoreshwa mu kumenya niba kanseri yarakwirakwiriye mu ngingo zoroshye cyangwa mu bindi bice by'umubiri byitwa kubika. Nta sisitemu isanzwe yo guteganyiriza abana bato tissue sarcoma.

Gutegura ubuvuzi, ni ngombwa kumenya ubwoko bwa tissue sarcoma yoroshye, niba ikibyimba gishobora gukurwaho no kubagwa, ndetse na kanseri yakwirakwiriye mu bindi bice byumubiri.

Uburyo bukurikira burashobora gukoreshwa kugirango umenye niba kanseri yarakwirakwiriye:

• Sentinel lymph node biopsy: Gukuraho lymph node ya sentinel mugihe cyo kubagwa. Sentinel lymph node niyambere ya lymph node mumatsinda ya lymph node yakira amazi ya lymphatique ava mubyimba byambere. Nibwo bwa mbere lymph node kanseri ishobora gukwirakwira kuva ikibyimba kibanza. Ikintu gikoresha radiyo na / cyangwa irangi ry'ubururu batewe inshinge hafi yikibyimba. Ibintu cyangwa irangi bitembera mumiyoboro ya lymph node. Lymph ya mbere yakira ibintu cyangwa irangi bivanwaho. Inzobere mu bijyanye n’indwara ireba tissue munsi ya microscope kugirango ishakishe selile. Niba kanseri ya kanseri itabonetse, ntibishobora kuba ngombwa gukuraho izindi lymph node. Rimwe na rimwe, lymph node ya sentinel iboneka mumatsinda arenze imwe. Ubu buryo bukoreshwa kuri epithelioid na selile sarcoma isobanutse.

• CT scan (CAT scan): Uburyo bukora urukurikirane rwamashusho arambuye yibice byimbere mumubiri, nkigituza, byafashwe muburyo butandukanye. Amashusho yakozwe na mudasobwa ihujwe na mashini ya x-ray. Irangi rishobora guterwa mumitsi cyangwa kumirwa kugirango bifashe ingingo cyangwa ingirangingo kugaragara neza. Ubu buryo kandi bwitwa computing tomografiya, tomografiya ya mudasobwa, cyangwa mudasobwa ya axial tomografiya.

• PET scan: PET scan nuburyo bwo gushakisha ingirabuzimafatizo mbi mu mubiri. Umubare muto wa glucose ikora radio (isukari) yatewe mumitsi. PET scaneri izenguruka umubiri kandi ikora ishusho yerekana aho glucose ikoreshwa mumubiri. Utugingo ngengabuzima twibibyimba twerekana neza cyane ku ishusho kuko zikora cyane kandi zifata glucose nyinshi kuruta selile zisanzwe. Ubu buryo bwitwa positron emission tomografiya (PET) scan.

• PET-CT scan: Uburyo bukomatanya amashusho kuva PET scan hamwe na tomografi yabazwe (CT) scan. Gusikana PET na CT bikorwa icyarimwe kumashini imwe. Amashusho yo muri scan zombi arahujwe kugirango akore ishusho irambuye kuruta ikizamini cyonyine.

Hariho uburyo butatu kanseri ikwirakwira mu mubiri.

Kanseri irashobora gukwirakwira binyuze mu ngingo, sisitemu ya lymph, n'amaraso:

• Tissue. Kanseri ikwirakwira aho yatangiriye ikurira mu turere twegereye.

• Sisitemu ya Lymph. Kanseri ikwirakwira aho yatangiriye yinjira muri sisitemu ya lymph. Kanseri inyura mu mitsi ya lymph igana mu bindi bice by'umubiri.

• Amaraso. Kanseri ikwirakwira aho yatangiriye yinjira mu maraso. Kanseri inyura mu mitsi y'amaraso igana mu bindi bice by'umubiri.

Kanseri irashobora gukwirakwira aho yatangiriye no mu bindi bice byumubiri.

Iyo kanseri ikwirakwira mu kindi gice cy'umubiri, yitwa metastasis. Ingirabuzimafatizo za kanseri zitandukana aho zatangiriye (ikibyimba kibanza) zikanyura muri sisitemu ya lymph cyangwa maraso.

• Sisitemu ya Lymph. Kanseri yinjira muri sisitemu ya lymph, ikanyura mu mitsi ya lymph, igakora ikibyimba (ikibyimba metastatike) mu kindi gice cy'umubiri.

• Amaraso. Kanseri yinjira mu maraso, ikanyura mu mitsi y'amaraso, igakora ikibyimba (ikibyimba metastatike) mu kindi gice cy'umubiri.

Ikibyimba metastatike nubwoko bumwe bwa kanseri nkibibyimba byibanze. Kurugero, niba sarcoma yoroheje yoroheje ikwirakwira mu bihaha, selile ya kanseri mu bihaha ni selile yoroshye ya sarcoma. Indwara ni metastatike yoroheje tissue sarcoma, ntabwo ari kanseri y'ibihaha.

Isubiramo kandi Itera Ubwana Byoroheje Tissue Sarcoma

Isubiramo ryubwana bworoheje tissue sarcoma ni kanseri yagarutse (yagarutse) nyuma yo kuvurwa. Kanseri irashobora kuba yagarutse ahantu hamwe cyangwa mubindi bice byumubiri.

Iterambere ryubwana bworoheje tissue sarcoma ni kanseri ititabira kwivuza.

Incamake yo kuvura

INGINGO Z'INGENZI

• Hariho uburyo butandukanye bwo kuvura abarwayi bafite tissue yoroshye ya sarcoma.

• Abana bafite tissue yoroshye ya sarcoma yo mu bwana bagomba guteganya ubuvuzi bwateguwe nitsinda ryabatanga ubuvuzi ninzobere mu kuvura kanseri mubana.

• Umuti wo mu bwana bworoshye tissue sarcoma urashobora gutera ingaruka.

• Ubwoko burindwi bwo kuvura busanzwe bukoreshwa:

• Kubaga

• Imiti ivura imirasire

• Chimoterapi

• Indorerezi

• Ubuvuzi bugamije

• Immunotherapy

• Ubundi buryo bwo kuvura ibiyobyabwenge

• Ubwoko bushya bwo kuvura burimo kugeragezwa mubigeragezo byamavuriro.

• Ubuvuzi bwa Gene

• Abarwayi barashobora kwifuza gutekereza kubijyanye no kwipimisha kwa muganga.

• Abarwayi barashobora kwipimisha kwa muganga mbere, mugihe, cyangwa nyuma yo gutangira kuvura kanseri.

• Ibizamini byo gukurikirana birashobora gukenerwa.

Hariho uburyo butandukanye bwo kuvura abarwayi bafite tissue yoroshye ya sarcoma.

Ubwoko butandukanye bwo kuvura burahari kubarwayi bafite tissue yoroshye ya sarcoma. Bumwe mu buryo busanzwe (ubuvuzi bukoreshwa ubu), kandi bumwe burimo kugeragezwa mubigeragezo byamavuriro. Ikigeragezo kivura ni ubushakashatsi bwakozwe bugamije gufasha kunoza imiti igezweho cyangwa kubona amakuru ku buvuzi bushya ku barwayi ba kanseri. Iyo ibizamini byo kwa muganga byerekana ko ubuvuzi bushya buruta ubuvuzi busanzwe, ubuvuzi bushya bushobora kuba ubuvuzi busanzwe.

Kubera ko kanseri mu bana idasanzwe, kugira uruhare mu igeragezwa ry’amavuriro bigomba kwitabwaho. Ibigeragezo bimwe na bimwe bivura abarwayi batatangiye kwivuza.

Abana bafite tissue yoroshye ya sarcoma yo mu bwana bagomba guteganya ubuvuzi bwateguwe nitsinda ryabatanga ubuvuzi ninzobere mu kuvura kanseri mubana.

Umuti uzakurikiranwa n’umuganga w’abana oncologue, umuganga winzobere mu kuvura abana barwaye kanseri. Oncologue wabana akorana nabandi bashinzwe ubuzima bafite ubuhanga bwo kuvura abana barwaye tissue yoroshye sarcoma kandi bazobereye mubice bimwe na bimwe byubuvuzi. Ibi birashobora kubamo umuganga wabana babaga bafite imyitozo idasanzwe mugukuraho sarcomas yoroshye. Inzobere zikurikira nazo zishobora kubamo:

• Umuganga w'abana.

• Imirasire ya oncologue.

• Inzobere mu kuvura indwara z'abana.

• Inzobere mu baforomo b'abana.

• Inzobere mu gusubiza mu buzima busanzwe.

• Umuhanga mu by'imitekerereze ya muntu.

• Ushinzwe imibereho myiza.

• Inzobere mu buzima bw'umwana.

Umuti wo mu bwana bworoshye tissue sarcoma urashobora gutera ingaruka.

Kumakuru yingaruka zitangira mugihe cyo kuvura kanseri, reba urupapuro rwuruhande rwacu.

Ingaruka ziterwa no kuvura kanseri zitangira nyuma yo kuvurwa zikomeza amezi cyangwa imyaka byitwa ingaruka zitinze. Ingaruka zo kuvura kanseri zishobora kubamo:

• Ibibazo byumubiri.

• Impinduka mumyumvire, ibyiyumvo, gutekereza, kwiga, cyangwa kwibuka.

• Kanseri ya kabiri (ubwoko bushya bwa kanseri).

Ingaruka zimwe zitinze zishobora kuvurwa cyangwa kugenzurwa. Ni ngombwa kuganira n'abaganga b'umwana wawe ku ngaruka kuvura kanseri bishobora kugira ku mwana wawe. (Reba incamake ya ku ngaruka zitinze zo kuvura kanseri y'abana kugira ngo umenye amakuru.)

Ubwoko burindwi bwo kuvura busanzwe bukoreshwa:

Kubaga

Kubaga gukuraho burundu tissue yoroshye sarcoma bikorwa mugihe bishoboka. Niba ikibyimba ari kinini cyane, imiti ivura imirasire cyangwa chimiotherapie irashobora gutangwa mbere, kugirango ikibyimba kibe gito kandi kigabanye umubare winyama zigomba kuvaho mugihe cyo kubagwa. Ibi byitwa neoadjuvant (preoperative) therapy.

Ubwoko bukurikira bwo kubaga bushobora gukoreshwa:

• Kwiyegereza kwagutse: Gukuraho ikibyimba hamwe nibisanzwe bisanzwe bikikije.

• Amputation: Kubaga kugirango ukureho byose cyangwa igice cyamaboko cyangwa ukuguru hamwe na kanseri.

• Lymphadenectomy: Gukuraho lymph node hamwe na kanseri.

• Kubaga Mohs: Uburyo bwo kubaga bukoreshwa mu kuvura kanseri mu ruhu. Ibice bitandukanye bya kanseri ya kanseri bivanwaho kandi bigasuzumwa munsi ya microscope icyarimwe kugeza igihe kanseri yose yakuweho. Ubu bwoko bwo kubaga bukoreshwa mu kuvura dermatofibrosarcoma protuberans.

Yitwa kandi Mohs micrographic surgery.

• Hepatectomy: Kubaga kugirango ukureho umwijima wose cyangwa igice.

Kubaga kabiri birashobora gukenerwa:

• Kuraho selile zose zisigaye.

• Reba ahantu hafi yakuweho ikibyimba kanseri ya kanseri hanyuma ukureho izindi tissue nibikenewe.

Niba kanseri iri mu mwijima, hashobora gukorwa hepatectomie no guhinduranya umwijima (umwijima ukurwaho ugasimbuzwa undi muzima ku baterankunga).

Muganga amaze gukuraho kanseri zose zishobora kugaragara mugihe cyo kubagwa, abarwayi bamwe bashobora guhabwa chimiotherapie cyangwa imiti ivura imirasire nyuma yo kubagwa kugirango bice selile zose zisigaye. Umuti watanzwe nyuma yo kubagwa, kugirango ugabanye ibyago ko kanseri izagaruka, byitwa kuvura indwara.

Imiti ivura imirasire

Imishwarara ivura ni imiti ikoresha kanseri ikoresha ingufu nyinshi za x-imirasire cyangwa ubundi bwoko bwimirasire yica kanseri cyangwa ikabuza gukura. Hariho ubwoko bubiri bwo kuvura imirasire:

• Imiti ivura hanze ikoresha imashini hanze yumubiri kugirango yohereze imirasire kuri kanseri. Uburyo bumwe na bumwe bwo gutanga imishwarara irashobora gufasha kurinda imirasire kwangiza ingirabuzimafatizo nziza. Ubu bwoko bwo kuvura imirasire bushobora kubamo ibi bikurikira:

• Ubuvuzi bwa stereotactique yumubiri: Ubuvuzi bwimirasire yumubiri ni ubwoko bwimiti ivura hanze. Ibikoresho bidasanzwe bikoreshwa mugushira umurwayi mumwanya umwe kuri buri kuvura imirasire. Rimwe kumunsi muminsi myinshi, imashini imirasire igamije kurenza urugero rusanzwe rwimirasire yibibyimba. Mugihe umurwayi afite umwanya umwe kuri buri kuvura, nta byangiritse cyane kumubiri muzima uri hafi. Ubu buryo bwitwa kandi stereotactique yo hanze-beam ivura imishwarara hamwe nubuvuzi bwa stereotaxic.

• Imiti ivura imbere ikoresha ibintu bifata radiyo bifunze inshinge, imbuto, insinga, cyangwa catheteri bishyirwa muri kanseri cyangwa hafi yayo.

Niba imiti ivura imirasire itangwa mbere cyangwa nyuma yo kubagwa kugirango ikureho kanseri biterwa n'ubwoko n'icyiciro cya kanseri ivurwa, niba hari kanseri ya kanseri igumye nyuma yo kubagwa, n'ingaruka ziteganijwe zo kuvurwa. Imishwarara yo hanze ninyuma ikoreshwa mugukiza tissue yoroshye ya sarcoma.

Chimoterapi

Chimoterapi ni umuti wa kanseri ukoresha ibiyobyabwenge kugirango uhagarike imikurire ya kanseri, haba mu kwica selile cyangwa kubabuza gutandukana. Iyo chimiotherapie ifashwe numunwa cyangwa igaterwa mumitsi cyangwa imitsi, imiti yinjira mumaraso kandi irashobora kugera kanseri ya kanseri mumubiri (chimiotherapie sisitemu). Iyo chimiotherapie ishyizwe mumazi yubwonko, urugingo, cyangwa umwobo wumubiri nkinda, imiti yibasira kanseri ya kanseri muri utwo turere (chimiotherapie yo mukarere). Imiti ya chimiotherapie ni ugukoresha imiti irenga imwe ya anticancer.

Uburyo chimiotherapie itangwa biterwa n'ubwoko bwa tissue tissue sarcoma ivurwa. Ubwoko bwinshi bwa tissue yoroshye sarcoma ntabwo yitabira kuvura hamwe na chimiotherapie.

Reba Ibiyobyabwenge Byemewe kuri Tissue Tissue Sarcoma kubindi bisobanuro.

Indorerezi

Indorerezi ikurikiranira hafi imiterere yumurwayi idatanga imiti kugeza ibimenyetso cyangwa ibimenyetso bigaragara cyangwa bihindutse. Indorerezi irashobora gukorwa iyo:

• Kurandura burundu ikibyimba ntibishoboka.

• Nta bundi buryo bwo kuvura buboneka.

• Ikibyimba ntigishobora kwangiza ingingo zose zingenzi.

Indorerezi irashobora gukoreshwa mu kuvura fibromatose yo mu bwoko bwa desmoid, fibrosarcoma y'abana, PEComa, cyangwa epithelioid hemangioendothelioma.

Ubuvuzi bugamije

Ubuvuzi bugamije ni uburyo bwo kuvura bukoresha ibiyobyabwenge cyangwa ibindi bintu byibasira kanseri. Ubuvuzi bugamije ubusanzwe butera kwangirika kwingirabuzimafatizo zisanzwe kuruta chimiotherapie cyangwa imirasire.

• Inhibitor ya Kinase ihagarika enzyme yitwa kinase (ubwoko bwa poroteyine). Hariho ubwoko butandukanye bwa kinase mumubiri ufite ibikorwa bitandukanye.

• ALK inhibitor irashobora guhagarika kanseri gukura no gukwirakwira. Crizotinib irashobora gukoreshwa mukuvura ikibyimba cya myofibroblastique na fibrosarcoma yibana.

• Tyrosine kinase inhibitor (TKIs) ibuza ibimenyetso bikenewe kugirango ibibyimba bikure. Imatinib ikoreshwa mu kuvura dermatofibrosarcoma protuberans. Pazopanib irashobora gukoreshwa mukuvura fibromatose yo mu bwoko bwa desmoid, epithelioid hemangioendothelioma, hamwe nubwoko bumwe na bumwe bwisubiramo kandi bugenda butera imbere sarcoma. Sorafenib irashobora gukoreshwa mu kuvura fibromatose yo mu bwoko bwa desmoid na epithelioid hemangioendothelioma. Sunitinib irashobora gukoreshwa mukuvura alveolar yoroshye igice sarcoma. Larotrectinib ikoreshwa mu kuvura fibrosarcoma. Ceritinib ikoreshwa mu kuvura ikibyimba cya myofibroblastique.

• Inhibitor ya mTOR ni ubwoko bwubuvuzi bugamije guhagarika poroteyine ifasha selile kugabana no kubaho. Inhibitori ya mTOR irakoreshwa mukuvura ibibyimba bito bito bya desmoplastique bigenda byiyongera, PEComa, na epithelioid hemangioendothelioma kandi barimo kwigwa kuvura ikibyimba kibi cya periferique. Sirolimusi na temsirolimus ni ubwoko bwa mTOR inhibitor therapy.

Ubwoko bushya bwa tyrosine kinase inhibitor burimo kwigwa nka:

• Entrectinib ya fibrosarcoma yibana.

• Trametinib kuri epithelioid hemangioendothelioma.

Ubundi bwoko bwubuvuzi bugamije kwigwa mubigeragezo byamavuriro, harimo ibi bikurikira:

• Indwara ya Angiogenezi ni ubwoko bwubuvuzi bugamije gukumira imikurire mishya yamaraso ikenewe kugirango ibibyimba bikure. Indwara ya Angiogenezi, nka cediranib, sunitinib, na thalidomide irimo kwigwa kugirango ivure igice cyoroshye cya alveolar sarcoma na epithelioid hemangioendothelioma. Bevacizumab ikoreshwa mukuvura angiosarcoma.

• Inhibitori ya Histone methyltransferase (HMT) ni imiti igamije kuvura ikorera mu ngirabuzimafatizo za kanseri kandi ikabuza ibimenyetso bikenewe kugira ngo ibibyimba bikure. Inzitizi za HMT, nka tazemetostat, zirimo kwigwa kugira ngo zivurwe ikibyimba kibi cya periferique nervice sheath tumor, epithelioid sarcoma, myxoid chondrosarcoma ya extraaskeletal, hamwe na kanseri ya rhabdoid idasanzwe.

• Ubushyuhe bwa poroteyine ibuza poroteyine zimwe na zimwe zirinda ingirabuzimafatizo kandi zikabafasha gukura. Ganetespib ni poroteyine yubushyuhe ya poroteyine irimo kwigwa hamwe na mTOR inhibitor sirolimus ya malignant peripheral nerv sheath tumers idashobora gukurwaho no kubagwa.

• ICYITONDERWA CY'inzira ni ubwoko bwubuvuzi bugenewe bukora imbere muri kanseri ya kanseri kandi bugahagarika ibimenyetso bikenewe kugirango ibibyimba bikure.

ICYITONDERWA CY'inzira zibuza kwigwa kuvura fibromatose yo mu bwoko bwa desmoid.

Reba Ibiyobyabwenge Byemewe kuri Tissue Tissue Sarcoma kubindi bisobanuro.

Immunotherapy

Immunotherapy nubuvuzi bukoresha sisitemu yumubiri yumurwayi kurwanya kanseri. Ibintu bikozwe numubiri cyangwa bikozwe muri laboratoire bikoreshwa mukuzamura, kuyobora, cyangwa kugarura umubiri kamere irinda kanseri. Ubu bwoko bwo kuvura nabwo bwitwa biotherapy cyangwa biologic therapy.

Interferon na immune checkpoint inhibitor therapy ni ubwoko bwikingira.

• Interferon ibangamira igabana ry'uturemangingo tw'ibibyimba kandi irashobora gutinda gukura kw'ibibyimba. Ikoreshwa mukuvura epithelioid hemangioendothelioma.

• Immune checkpoint inhibitor therapy: Ubwoko bumwebumwe bwingirangingo, nka selile T, hamwe na kanseri zimwe na zimwe zifite poroteyine zimwe na zimwe, bita proteine ​​proteyine, hejuru yabyo bikomeza kugenzura ubudahangarwa bw'umubiri. Iyo kanseri ya kanseri ifite proteine ​​nyinshi, ntabwo zizaterwa no kwicwa na selile T. Immune igenzura ibuza izo poroteyine kandi ubushobozi bwa selile T bwo kwica kanseri bwiyongera.

Hariho ubwoko bubiri bwubudahangarwa bwo kugenzura indwara:

• CTLA-4 inhibitor: CTLA-4 ni poroteyine hejuru ya selile T ifasha kugenzura ubudahangarwa bw'umubiri. Iyo CTLA-4 ifashe indi poroteyine yitwa B7 kuri selile ya kanseri, ibuza selile T kwica kanseri. Inzitizi za CTLA-4 zifatanije na CTLA-4 kandi zemerera selile T kwica kanseri. Ipilimumab ni ubwoko bwa CTLA-4 inhibitor irimo kwigwa kuvura angiosarcoma.

Immune igenzura. Intungamubiri za poroteyine, nka B7-1 / B7-2 kuri selile zerekana antigen (APC) na CTLA-4 kuri selile T, zifasha kugenzura ubudahangarwa bw'umubiri. Iyo reseptor ya T-selile (TCR) ihuza na poroteyine za antigen hamwe ningenzi zikomeye za histocompatibilité (MHC) kuri APC na CD28 zihuza B7-1 / B7-2 kuri APC, selile T irashobora gukora. Ariko, guhuza B7-1 / B7-2 na CTLA-4 bituma selile T zidakora kuburyo zidashobora kwica selile yibibyimba mumubiri (panne ibumoso). Guhagarika guhuza B7-1 / B7-2 na CTLA-4 hamwe na inhibitor igenzura (antibody anti-CTLA-4) ituma selile T ikora kandi ikica selile yibibyimba (panel iburyo).

• PD-1 inhibitor: PD-1 ni poroteyine hejuru ya selile T ifasha kugenzura ubudahangarwa bw'umubiri. Iyo PD-1 ifatanye nindi poroteyine yitwa PDL-1 kuri selile ya kanseri, ibuza selile T kwica kanseri. Inzitizi za PD-1 zifatanije na PDL-1 kandi zemerera selile T kwica selile. Pembrolizumab ni ubwoko bwa PD-1 inhibitor ikoreshwa mukuvura sarcoma yoroheje kandi igenda isubirwamo. Nivolumab ni ubwoko bwa PD-1 inhibitor irimo kwigwa kuvura angiosarcoma.

Immune igenzura. Intungamubiri za poroteyine, nka PD-L1 ku ngirabuzimafatizo na PD-1 kuri selile T, zifasha kugenzura ibisubizo by’ubudahangarwa. Guhambira PD-L1 na PD-1 bituma selile T itica selile yibibyimba mumubiri (panne ibumoso). Guhagarika guhuza PD-L1 na PD-1 hamwe na inhibitor igenzura (anti-PD-L1 cyangwa anti-PD-1) ituma selile T yica selile yibibyimba (panne iburyo).

Ubundi buryo bwo kuvura ibiyobyabwenge

Ubuvuzi bwa Steroid bugira ingaruka za antitumor mubyimba myofibroblastique.

Ubuvuzi bwa Hormone nubuvuzi bwa kanseri bukuraho imisemburo cyangwa ikabuza ibikorwa byayo kandi ikabuza kanseri gukura. Hormone ni ibintu bikozwe na glande mu mubiri kandi bikwirakwizwa mu maraso. Imisemburo imwe n'imwe irashobora gutuma kanseri zimwe zikura. Niba ibizamini byerekana ko kanseri ya kanseri ifite aho imisemburo ishobora kwomeka (reseptors), ibiyobyabwenge, kubaga, cyangwa kuvura imirasire bikoreshwa mukugabanya imisemburo cyangwa kubabuza gukora. Antiestrogène (imiti ibuza estrogene), nka tamoxifen, irashobora gukoreshwa mu kuvura fibromatose yo mu bwoko bwa desmoid. Prasterone iri kwigwa kuvura sarcoma ya synovial.

Imiti ya Nonsteroidal anti-inflammatory (NSAIDs) ni ibiyobyabwenge (nka aspirine, ibuprofen, na naproxen) bikunze gukoreshwa mu kugabanya umuriro, kubyimba, kubabara, no gutukura. Mu kuvura fibromatose yo mu bwoko bwa desmoid, NSAID yitwa sulindac irashobora gukoreshwa kugirango ifashe gukura kwingirangingo za kanseri.

Ubwoko bushya bwo kuvura burimo kugeragezwa mubigeragezo byamavuriro.

Iki gice cyincamake gisobanura imiti irimo kwigwa mubigeragezo byamavuriro. Ntishobora kuvuga ubuvuzi bushya burimo kwigwa. Amakuru yerekeye ibizamini byamavuriro araboneka kurubuga rwa NCI.

Ubuvuzi bwa Gene

Ubuvuzi bwa Gene burimo kwigwa kuri sarcoma ya synovial yo mu bwana yagarutse, ikwirakwira, cyangwa idashobora gukurwaho no kubagwa. Zimwe mu ngirabuzimafatizo za T z'umurwayi (ubwoko bw'uturemangingo tw'amaraso yera) zivanwaho kandi ingirabuzimafatizo ziri muri laboratoire (zakozwe na genetique) ku buryo zizatera kanseri yihariye. Baca basubizwa umurwayi gushiramo.

Abarwayi barashobora kwifuza gutekereza kubijyanye no kwipimisha kwa muganga.

Ku barwayi bamwe, kwitabira ikizamini cyamavuriro birashobora kuba uburyo bwiza bwo kuvura. Ibigeragezo bivura biri mubikorwa byubushakashatsi bwa kanseri. Igeragezwa rya Clinical rikorwa kugirango hamenyekane niba imiti mishya ya kanseri itekanye kandi ifite akamaro cyangwa nziza kuruta ubuvuzi busanzwe.

Benshi mubuvuzi busanzwe bwa kanseri bushingiye kubigeragezo byambere byubuvuzi. Abarwayi bitabiriye kwipimisha barashobora kuvurwa bisanzwe cyangwa kuba mubambere bahawe imiti mishya.

Abarwayi bitabira ibizamini byo kwa muganga nabo bafasha kunoza uburyo kanseri izavurwa mugihe kizaza. Nubwo ibigeragezo bivura bitaganisha ku buvuzi bushya, akenshi basubiza ibibazo byingenzi kandi bigafasha gutera imbere ubushakashatsi.

Abarwayi barashobora kwipimisha kwa muganga mbere, mugihe, cyangwa nyuma yo gutangira kuvura kanseri.

Igeragezwa rimwe na rimwe ririmo abarwayi bataravurwa. Ibindi bigeragezo bipima abarwayi bafite kanseri itameze neza. Hariho kandi ibizamini byo kwa muganga bipima uburyo bushya bwo guhagarika kanseri kongera kugaruka (kugaruka) cyangwa kugabanya ingaruka zo kuvura kanseri.

Igeragezwa rya Clinical ririmo kubera mu bice byinshi by'igihugu. Amakuru yerekeye ibizamini byamavuriro ashyigikiwe na NCI urashobora kubisanga kurubuga rwa NCI. Ibizamini bya Clinical bishyigikiwe nandi mashyirahamwe murashobora kubisanga kurubuga rwa ClinicalTrials.gov.

Ibizamini byo gukurikirana birashobora gukenerwa.

Bimwe mubizamini byakozwe mugupima kanseri cyangwa kumenya icyiciro cya kanseri birashobora gusubirwamo. Ibizamini bimwe bizasubirwamo kugirango harebwe uburyo ubuvuzi bukora neza. Ibyemezo bijyanye no gukomeza, guhindura, cyangwa guhagarika ubuvuzi birashobora gushingira kubisubizo byibi bizamini.

Bimwe mubizamini bizakomeza gukorwa buri gihe nyuma yubuvuzi burangiye. Ibisubizo by'ibi bizamini birashobora kwerekana niba imiterere y'umwana wawe yarahindutse cyangwa niba kanseri yarongeye (garuka). Ibi bizamini rimwe na rimwe byitwa gukurikirana-ibizamini cyangwa kugenzura.

Amahitamo yo Kuvura Ubwana Bumaze Gusuzumwa Byoroheje Tissue Sarcoma

Muri iki gice

• Ibibyimba by'ibibyibushye

• Liposarcoma

• Amagufwa na Cartilage

• Extraskeletal mesenchymal chondrosarcoma

• Osteosarcoma idasanzwe

• Ibibyimba bya Fibrous (Ihuza) Ibibyimba

• Ubwoko bwa fibromatose

• Dermatofibrosarcoma protuberans

• Ikibyimba cya myofibroblastique

• Fibrosarcoma

• Myxofibrosarcoma

• Fibromyxoid yo mu rwego rwo hasi

• Sclerose epithelioid fibrosarcoma

• Ibibyimba by'imitsi

• Rhabdomyosarcoma

• Ibibyimba byoroshye

• Leiomyosarcoma

• Ibyo bita Fibrohistiocytic Tumors

• Plexiform fibrohistiocytic ikibyimba

• Ibibyimba byo mu mitsi

• Malignant peripheral nerv sheath tumor

• Ikibyimba cya Triton

• Ectomesenchymoma

• Ibibyimba bya Pericyitike (Perivascular)

• Infantile hemangiopericytoma

• Infantile myofibromatose

• Ibibyimba Inkomoko y'utugari tutazwi (ahantu ikibyimba cyatangiriye bwa mbere ntabwo kizwi)

• Sarovoma

• Epithelioid sarcoma

• Alveolar yoroshye igice sarcoma

• Kuraho selile sarcoma ya tissue yoroshye

• Extraskeletal myxoid chondrosarcoma

• Extraskeletal Ewing sarcoma

• Desmoplastique ntoya yibibyimba

• Ikibyimba kidasanzwe (extracranial) rhabdoid ikibyimba

• Ibibyimba byo mu bwoko bwa epithelioid selile (PEComa)

• Sarcoma idatandukanijwe / idafite ibyiciro

• Indangamuntu ya pleomorphic sarcoma / malibant fibrous histiocytoma (urwego rwo hejuru)

• Ibibyimba byamaraso

• Epithelioid hemangioendothelioma

• Angiosarcoma yumubiri woroshye

• Metastatic Ubwana Bworoshye Tissue Sarcoma

Kumakuru yerekeye imiti yavuzwe hepfo, reba igice cyo kuvura

Ibibyimba by'ibibyibushye

Liposarcoma

Kuvura liposarcoma birashobora kubamo ibi bikurikira:

• Kubaga kugirango ukureho ikibyimba burundu. Niba kanseri idakuweho burundu, hashobora kubagwa kabiri.

• Chimiotherapie kugirango igabanye ikibyimba, ikurikirwa no kubagwa.

• Imiti ivura imirasire mbere cyangwa nyuma yo kubagwa.

Amagufwa na Cartilage

Extraskeletal mesenchymal chondrosarcoma

Kuvura mesenchymal chondrosarcoma idasanzwe irashobora kuba ikubiyemo ibi bikurikira:

• Kubaga kugirango ukureho ikibyimba burundu. Imiti ivura imirasire irashobora gutangwa mbere na / cyangwa nyuma yo kubagwa.

• Chimiotherapie ikurikirwa no kubagwa. Chimiotherapie hamwe cyangwa idafite imishwarara itangwa nyuma yo kubagwa.

Osteosarcoma idasanzwe

Kuvura osteosarcoma idasanzwe irashobora kubamo ibi bikurikira:

• Kubaga kugirango ukureho ikibyimba burundu, hakurikiraho chimiotherapie.

Reba incamake ya kuri Osteosarcoma na Malignant Fibrous Histiocytoma yo kuvura amagufwa kugirango umenye amakuru yerekeye kuvura osteosarcoma.

Ibibyimba bya Fibrous (Ihuza) Ibibyimba

Ubwoko bwa fibromatose

Kuvura fibromatose yo mu bwoko bwa desmoid irashobora kubamo ibi bikurikira:

• Kubaga kugirango ukureho ikibyimba burundu.

• Indorerezi, kubibyimba bidakuweho burundu no kubagwa cyangwa byagarutse (garuka) kandi ntibishobora kwangiza ingingo zose zingenzi.

• Chimoterapi yibibyimba bidakuweho rwose kubagwa cyangwa byagarutse.

• Ubuvuzi bugamije (sorafenib cyangwa pazopanib).

• Umuti wa Nonsteroidal anti-inflammatory (NSAID).

• Imiti igabanya ubukana.

• Imiti ivura imirasire.

• Igeragezwa rya clinique yubuvuzi bugamije hamwe na NOTCH inzira inhibitor.

Dermatofibrosarcoma protuberans

Kuvura dermatofibrosarcoma protuberans irashobora kuba ikubiyemo ibi bikurikira:

• Kubaga kugirango ukureho ikibyimba burundu igihe bishoboka. Ibi bishobora kubamo Mohs kubaga.

• Imiti ivura imirasire mbere cyangwa nyuma yo kubagwa.

• Imishwarara ivura hamwe nubuvuzi bugamije (imatinib) niba ikibyimba kidashobora gukurwaho cyangwa cyagarutse.

Ikibyimba cya myofibroblastique

Kuvura ikibyimba cya myofibroblastique gishobora kubamo ibi bikurikira:

• Kubaga kugirango ukureho ikibyimba burundu igihe bishoboka.

• Chimoterapi.

• Ubuvuzi bwa Steroid.

• Umuti wa Nonsteroidal anti-inflammatory (NSAID).

• Ubuvuzi bugamije (crizotinib na ceritinib).

Fibrosarcoma

Fibrosarcoma y'uruhinja

Kuvura fibrosarcoma yibana bishobora kuba bikubiyemo ibi bikurikira:

• Kubaga kugirango ukureho ikibyimba igihe bishoboka, hakurikiraho kwitegereza.

• Kubaga bikurikirwa na chimiotherapie.

• Chimiotherapie kugirango igabanye ikibyimba, ikurikirwa no kubagwa.

• Ubuvuzi bugamije (crizotinib na larotrectinib).

• Igeragezwa rya clinique risuzuma icyitegererezo cyibibyimba byumurwayi kugirango hahindurwe gene. Ubwoko bwo kuvura bugenewe umurwayi biterwa n'ubwoko bw'imihindagurikire ya gene.

• Ikigeragezo cyamavuriro yubuvuzi bugamije (larotrectinib cyangwa entrectinib).

Fibrosarcoma ikuze

Umuti wa fibrosarcoma ukuze urashobora kubamo ibi bikurikira:

• Kubaga kugirango ukureho ikibyimba burundu igihe bishoboka.

Myxofibrosarcoma

Umuti wa myxofibrosarcoma urashobora kubamo ibi bikurikira:

• Kubaga kugirango ukureho ikibyimba burundu.

Fibromyxoid yo mu rwego rwo hasi

Kuvura fibromyxoid yo mu rwego rwo hasi sarcoma irashobora kuba ikubiyemo ibi bikurikira:

• Kubaga kugirango ukureho ikibyimba burundu.

Sclerose epithelioid fibrosarcoma

Umuti wa sclerose epithelioid fibrosarcoma urashobora kubamo ibi bikurikira:

• Kubaga kugirango ukureho ikibyimba burundu.

Ibibyimba by'imitsi

Rhabdomyosarcoma

Reba incamake ya kubuvuzi bwa Rhabdomyosarcoma.

Ibibyimba byoroshye

Leiomyosarcoma

Umuti wa leiomyosarcoma urashobora kubamo ibi bikurikira:

• Chimoterapi.

Ibyo bita Fibrohistiocytic Tumors

Plexiform fibrohistiocytic ikibyimba

Kuvura ikibyimba cya plexiform fibrohistiocytic gishobora kubamo ibi bikurikira:

• Kubaga kugirango ukureho ikibyimba burundu.

Ibibyimba byo mu mitsi

Malignant peripheral nerv sheath tumor

Kuvura ibibyimba bibi bya periferique nervice sheath birashobora kuba bikubiyemo ibi bikurikira:

• Kubaga kugirango ukureho ikibyimba burundu igihe bishoboka.

• Imiti ivura imirasire mbere cyangwa nyuma yo kubagwa.

• Chimiotherapie, kubibyimba bidashobora gukurwaho no kubagwa.

• Igeragezwa rya clinique risuzuma icyitegererezo cyibibyimba byumurwayi kugirango hahindurwe gene. Ubwoko bwo kuvura bugenewe umurwayi biterwa n'ubwoko bw'imihindagurikire ya gene.

• Igeragezwa rya clinique yubuvuzi bugamije (ganetespib cyangwa sirolimus), kubibyimba bidashobora gukurwaho no kubagwa.

• Ikigeragezo cyamavuriro yubuvuzi bugenewe (tazemetostat).

Ntabwo byumvikana niba gutanga imiti ivura imirasire cyangwa chimiotherapie nyuma yo kubagwa byongera ikibyimba kubuvuzi.

Ikibyimba cya Triton

Ibibyimba bibi bya Triton birashobora gufatwa kimwe na rhabdomyosarcomas kandi bikubiyemo kubaga, chimiotherapie, cyangwa kuvura imirasire. Ntabwo byumvikana niba gutanga imiti ivura imirasire cyangwa chimiotherapie byongera ikibyimba kuvura.

Ectomesenchymoma

Kuvura ectomesenchymoma birashobora kuba bikubiyemo ibi bikurikira:

• Kubaga.

• Chimoterapi.

• Imiti ivura imirasire.

Ibibyimba bya Pericyitike (Perivascular)

Infantile hemangiopericytoma

Kuvura impinja hemangiopericytoma irashobora kuba ikubiyemo ibi bikurikira:

• Chimoterapi.

Infantile myofibromatose

Umuti wa myofibromatose wimpinja urashobora kubamo ibi bikurikira:

Ubuvuzi bwa chimiotherapie.

Ibibyimba Inkomoko y'utugari tutazwi (ahantu ikibyimba cyatangiriye bwa mbere ntabwo kizwi)

Sarovoma

Kuvura sarcoma ya synovial bishobora kuba bikubiyemo ibi bikurikira:

• Kubaga. Imiti ivura imirasire hamwe na / cyangwa chimiotherapie irashobora gutangwa mbere cyangwa nyuma yo kubagwa.

• Chimoterapi.

• Imiti ya stereotactique ivura ibibyimba byakwirakwiriye mu bihaha.

• Igeragezwa rya clinique yo kuvura gene.

• Igeragezwa rya clinique yo kuvura imisemburo.

Epithelioid sarcoma

Kuvura epithelioid sarcoma irashobora kuba ikubiyemo ibi bikurikira:

• Kubaga kugirango ukureho ikibyimba igihe bishoboka.

• Chimoterapi.

• Imiti ivura imirasire mbere cyangwa nyuma yo kubagwa.

• Ikigeragezo cyamavuriro yubuvuzi bugenewe (tazemetostat).

Alveolar yoroshye igice sarcoma

Kuvura alveolar yoroshye igice sarcoma irashobora kuba ikubiyemo ibi bikurikira:

• Kubaga kugirango ukureho ikibyimba burundu igihe bishoboka.

• Imiti ivura imirasire mbere cyangwa nyuma yo kubagwa, niba ikibyimba kidashobora gukurwaho burundu no kubagwa.

• Ubuvuzi bugamije (sunitinib).

• Igeragezwa rya clinique yubuvuzi bugenewe (cediranib cyangwa sunitinib) kubana.

Kuraho selile sarcoma ya tissue yoroshye

Kuvura sarcoma selile isobanutse ya tissue yoroshye irashobora kubamo ibi bikurikira:

• Kubaga kugirango ukureho ikibyimba igihe bishoboka.

• Imiti ivura imirasire mbere cyangwa nyuma yo kubagwa.

Extraskeletal myxoid chondrosarcoma

Umuti wa myxoid extraxkeletal chondrosarcoma urashobora kubamo ibi bikurikira:

• Kubaga kugirango ukureho ikibyimba igihe bishoboka.

• Imiti ivura imirasire.

• Ikigeragezo cyamavuriro yubuvuzi bugenewe (tazemetostat).

Extraskeletal Ewing sarcoma

Reba incamake ya kubijyanye no kuvura Ewing Sarcoma.

Desmoplastique ntoya yibibyimba

Nta buryo busanzwe bwo kuvura desmoplastique ntoya yibibyimba. Ubuvuzi bushobora kubamo ibi bikurikira:

• Kubaga kugirango ukureho ikibyimba burundu igihe bishoboka.

• Chimiotherapie ikurikirwa no kubagwa.

• Imiti ivura imirasire.

• Chimiotherapie hamwe nubuvuzi bugamije (temsirolimus), kubyimba byongeye.

Ikibyimba kidasanzwe (extracranial) rhabdoid ikibyimba

Kuvura ikibyimba kidasanzwe (extracranial) rhabdoid ikibyimba gishobora kuba gikubiyemo ibi bikurikira:

• Kubaga kugirango ukureho ikibyimba igihe bishoboka.

• Chimoterapi.

• Imiti ivura imirasire.

• Igeragezwa rya clinique risuzuma icyitegererezo cyibibyimba byumurwayi kugirango hahindurwe gene. Ubwoko bwo kuvura bugenewe umurwayi biterwa n'ubwoko bw'imihindagurikire ya gene.

• Ikigeragezo cyamavuriro yubuvuzi bugenewe (tazemetostat).

Ibibyimba byo mu bwoko bwa epithelioid selile (PEComa)

Kuvura ibibyimba bya selile epithelioid selile bishobora kuba bikubiyemo ibi bikurikira:

• Kubaga kugirango ukureho ikibyimba.

• Indorerezi ikurikirwa no kubagwa.

• Ubuvuzi bugamije (sirolimus), kubibyimba bifite ihinduka rya gene kandi ntibishobora gukurwaho no kubagwa.

Sarcoma idatandukanijwe / idafite ibyiciro

Indangamuntu ya pleomorphic sarcoma / malibant fibrous histiocytoma (urwego rwo hejuru)

Nta buryo busanzwe bwo kuvura ibyo bibyimba.

Reba incamake ya kuri Osteosarcoma na Malignant Fibrous Histiocytoma yo kuvura amagufwa kugirango umenye amakuru yerekeye kuvura fibrous histiocytoma yamagufa.

Ibibyimba byamaraso

Epithelioid hemangioendothelioma

Kuvura epithelioid hemangioendothelioma irashobora kubamo ibi bikurikira:

• Indorerezi.

• Kubaga kugirango ukureho ikibyimba igihe bishoboka.

• Immunotherapy (interferon) hamwe nubuvuzi bugamije (thalidomide, sorafenib, pazopanib, sirolimus) kubibyimba bishobora gukwirakwira.

• Chimoterapi.

• Hepatectomy yose hamwe no guhinduranya umwijima mugihe ikibyimba kiri mwumwijima.

• Ikigeragezo cyamavuriro yubuvuzi bugamije (trametinib).

Angiosarcoma yumubiri woroshye

Kuvura angiosarcoma birashobora kuba bikubiyemo ibi bikurikira:

• Kubaga kugirango ukureho ikibyimba burundu.

• Ihuriro ryo kubaga, chimiotherapie, hamwe no kuvura imirasire ya angiosarcomas yakwirakwiriye.

• Ubuvuzi bugamije (bevacizumab) hamwe na chimiotherapie ya angiosarcomas yatangiye nka hemangioma yibana.

• Igeragezwa rya chimiotherapie hamwe cyangwa idafite intego yo kuvura (pazopanib).

• Igeragezwa rya kliniki yubudahangarwa (nivolumab na ipilimumab).

Metastatic Ubwana Bworoshye Tissue Sarcoma

Umuti wo kuvura bwana bwana bwana sarcoma yakwirakwiriye mubindi bice byumubiri mugupima bishobora kuba bikubiyemo ibi bikurikira:

• Ubuvuzi bwa chimiotherapie hamwe nubuvuzi bwimirasire. Kubaga birashobora gukorwa kugirango bakureho ibibyimba byakwirakwiriye mu bihaha.

• Stereotactique yumubiri ivura ibibyimba byakwirakwiriye mu bihaha.

Kugirango uvure ubwoko bwibibyimba byihariye, reba uburyo bwo kuvura bwana bwana Tissue Sarcoma igice.

Uburyo bwo Kuvura Kubisubiramo kandi Bitera Ubwana Byoroheje Tissue Sarcoma

Ubuvuzi bwisubiramo cyangwa butera imbere bwana bworoheje tissue sarcoma bushobora kubamo ibi bikurikira:

• Kubaga kugirango ukureho kanseri yagarutse aho yatangiriye bwa mbere cyangwa yakwirakwiriye mu bihaha.

• Kubaga bikurikirwa no kuvura imirasire yo hanze cyangwa imbere, niba imiti ivura imirasire itaratangwa.

• Kubaga kugirango ukureho ukuboko cyangwa ukuguru hamwe na kanseri, niba imiti ivura imirasire yari imaze gutangwa.

• Kubaga hamwe na chimiotherapie ya sarcoma isubirwamo.

• Chimoterapi.

• Ubuvuzi bugamije (pazopanib).

• Immunotherapy (pembrolizumab).

• Ubuvuzi bwa stereotactique yumubiri wa kanseri yakwirakwiriye mubindi bice byumubiri, cyane cyane ibihaha.

• Ikigeragezo cyamavuriro yuburyo bushya bwa chimiotherapie hamwe nubuvuzi butagenewe (pazopanib).

• Igeragezwa rya clinique risuzuma icyitegererezo cyibibyimba byumurwayi kugirango hahindurwe gene. Ubwoko bwo kuvura bugenewe umurwayi biterwa n'ubwoko bw'imihindagurikire ya gene.

Koresha ubushakashatsi bwamavuriro kugirango ushakishe NCI ifashwa na kanseri ivura abarwayi. Urashobora gushakisha ibigeragezo ukurikije ubwoko bwa kanseri, imyaka yumurwayi, n’aho ibizamini bikorerwa. Amakuru rusange yerekeye ibizamini byamavuriro nayo arahari.

Kwiga Byinshi Kubana Byoroheje Tissue Sarcoma

Kubindi bisobanuro byaturutse mu kigo cyigihugu cya kanseri kubyerekeye ubwonko bworoshye bwitwa sarcoma, reba ibi bikurikira:

• Urupapuro rworoshye Sarcoma Urupapuro rwurugo

• Kubara Tomografiya (CT) Gusikana na Kanseri

• Ibiyobyabwenge Byemewe kuri Sarcoma Yoroheje

• Intego zo kuvura Kanseri

• MyPART - Urubuga rwanjye rwabana nabakuze Ntibisanzwe

Kubindi bisobanuro bya kanseri yo mu bwana hamwe nubundi buryo rusange bwa kanseri, reba ibi bikurikira:

• Ibyerekeye Kanseri

• Kanseri yo mu bwana

• Umuti wo Gushakisha Kanseri Yabana Kureka

• Ingaruka Zitinze Kuvura Kanseri Yabana

• Ingimbi n'abangavu bafite kanseri

• Abana barwaye Kanseri: Imfashanyigisho ku babyeyi

• Kanseri mu bana n'ingimbi

• Gutegura

• Guhangana na Kanseri

• Ibibazo byo Kubaza Muganga wawe kuri Kanseri

• Abacitse ku icumu n'abarezi