Ubwoko / pheochromocytoma / umurwayi / pheochromocytoma-kuvura-pdq

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Indwara ya Pheochromocytoma na Paraganglioma (®) - Indwara y'abarwayi

Amakuru Rusange Yerekeye Pheochromocytoma na Paraganglioma

INGINGO Z'INGENZI

  • Pheochromocytoma na paraganglioma ni ibibyimba bidasanzwe biva mubwoko bumwe.
  • Pheochromocytoma ni ikibyimba kidasanzwe kibaho muri medula ya adrenal (hagati ya glande ya adrenal).
  • Paraganglioma ikora hanze ya glande ya adrenal.
  • Indwara zimwe na zimwe twarazwe hamwe nimpinduka muri genes zimwe na zimwe byongera ibyago bya pheochromocytoma cyangwa paraganglioma.
  • Ibimenyetso nibimenyetso bya pheochromocytoma na paraganglioma harimo umuvuduko ukabije wamaraso no kubabara umutwe.
  • Ibimenyetso nibimenyetso bya pheochromocytoma na paraganglioma bishobora kubaho igihe icyo aricyo cyose cyangwa bizanwa nibintu bimwe.
  • Ibizamini bisuzuma amaraso ninkari bikoreshwa mugushakisha (gushakisha) no gusuzuma pheochromocytoma na paraganglioma.
  • Ubujyanama bwa genetike buri muri gahunda yo kuvura abarwayi bafite pheochromocytoma cyangwa paraganglioma.
  • Ibintu bimwe bigira ingaruka kubitekerezo (amahirwe yo gukira) hamwe nuburyo bwo kuvura.

Pheochromocytoma na paraganglioma ni ibibyimba bidasanzwe biva mubwoko bumwe.

Paraganglioma ikora mumyanya myakura muri glande ya adrenal no hafi yimiyoboro yamaraso hamwe nimitsi. Paraganglioma ikora muri glande ya adrenal yitwa pheochromocytoma. Paraganglioma ikora hanze ya glande ya adrenal yitwa paraganglioma idasanzwe. Muri iyi ncamake, paraganglioma idasanzwe-adrenal yitwa paraganglioma.

Pheochromocytoma na paraganglioma birashobora kuba byiza (ntabwo ari kanseri) cyangwa bibi (kanseri).

Pheochromocytoma ni ikibyimba kidasanzwe kibaho muri medula ya adrenal (hagati ya glande ya adrenal).

Pheochromocytoma ikora muri glande ya adrenal. Hariho glande ebyiri za adrenal, imwe hejuru ya buri mpyiko inyuma yinda yo hejuru. Buri glande ya adrenal ifite ibice bibiri. Igice cyo hanze cya glande ya adrenal ni cortex ya adrenal. Hagati ya glande ya adrenal ni medula ya adrenal.

Pheochromocytoma ni ikibyimba kidasanzwe cya medula ya adrenal. Ubusanzwe, pheochromocytoma ifata glande imwe ya adrenal, ariko irashobora kugira ingaruka kuri glande zombi. Rimwe na rimwe, hari ibibyimba birenze kimwe muri glande imwe ya adrenal.

Glande ya adrenal ikora imisemburo ikomeye yitwa catecholamine. Adrenaline (epinephrine) na noradrenaline (norepinephrine) ni ubwoko bubiri bwa catecholamine ifasha kugenzura umuvuduko wumutima, umuvuduko wamaraso, isukari yamaraso, nuburyo umubiri witwara mukibazo. Rimwe na rimwe, pheochromocytoma irekura adrenaline na noradrenaline mu maraso kandi bigatera ibimenyetso cyangwa ibimenyetso byindwara.

Anatomy ya glande ya adrenal. Hariho glande ebyiri za adrenal, imwe hejuru ya buri mpyiko. Igice cyo hanze cya buri glande ni cortex ya adrenal; igice cy'imbere ni medrenla adrenal.

Paraganglioma ikora hanze ya glande ya adrenal.

Paraganglioma ni ibibyimba bidasanzwe biboneka hafi yimitsi ya karoti, kumihanda yumutima mumutwe no mumajosi, no mubindi bice byumubiri. Paraganglioma zimwe zikora catecholamine zitwa adrenaline na noradrenaline. Isohora rya catecholamine yinyongera mumaraso rishobora gutera ibimenyetso cyangwa ibimenyetso byindwara.

Paraganglioma yumutwe nijosi. Ikibyimba kidasanzwe gikunze kugaragara hafi yimitsi ya karoti. Irashobora kandi gukora inzira yinzira yumutwe no mumutwe no mubindi bice byumubiri.

Indwara zimwe na zimwe twarazwe hamwe nimpinduka muri genes zimwe na zimwe byongera ibyago bya pheochromocytoma cyangwa paraganglioma.

Ikintu cyose cyongera amahirwe yo kwandura indwara cyitwa impanuka. Kugira ibintu bishobora guteza ingaruka ntabwo bivuze ko uzarwara kanseri; kutagira ibyago bishobora gusobanura ko utazarwara kanseri. Vugana na muganga wawe niba utekereza ko ushobora guhura n'akaga.

Indwara ya syndromes ikurikira cyangwa ihinduka rya gene byongera ibyago bya pheochromocytoma cyangwa paraganglioma:

  • Indwara nyinshi ya endocrine neoplasia 2 syndrome, ubwoko A na B (MEN2A na MEN2B).
  • von Hippel-Lindau (VHL) syndrome.
  • Neurofibromatose ubwoko bwa 1 (NF1).
  • Indwara ya paraganglioma.
  • Carney-Stratakis dyad (paraganglioma na gastrointestinal stromal tumor [GIST]).
  • Inyabutatu ya Carney (paraganglioma, GIST, na chondroma yimpaha).

Ibimenyetso nibimenyetso bya pheochromocytoma na paraganglioma harimo umuvuduko ukabije wamaraso no kubabara umutwe.

Ibibyimba bimwe na bimwe ntibikora adrenaline cyangwa noradrenaline kandi ntibitera ibimenyetso nibimenyetso. Ibi bibyimba rimwe na rimwe biboneka mugihe ibibyimba bibaye mwijosi cyangwa mugihe ikizamini cyangwa inzira ikozwe kubwindi mpamvu. Ibimenyetso nibimenyetso bya pheochromocytoma na paraganglioma bibaho mugihe adrenaline cyangwa noradrenaline irekuye mumaraso. Ibi bimenyetso nibindi bimenyetso bishobora guterwa na pheochromocytoma na paraganglioma cyangwa nibindi bihe. Menyesha umuganga wawe niba ufite kimwe muri ibi bikurikira:

  • Umuvuduko ukabije w'amaraso.
  • Kubabara umutwe.
  • Kubira ibyuya byinshi nta mpamvu izwi.
  • Umutima ukomeye, wihuta, cyangwa udasanzwe.
  • Guhinda umushyitsi.
  • Kuba mwiza cyane.

Ikimenyetso gikunze kugaragara ni umuvuduko ukabije w'amaraso. Birashobora kugorana kubigenzura. Umuvuduko ukabije wamaraso urashobora gutera ibibazo bikomeye byubuzima nko gutera umutima bidasanzwe, gutera umutima, ubwonko, cyangwa urupfu.

Ibimenyetso nibimenyetso bya pheochromocytoma na paraganglioma bishobora kubaho igihe icyo aricyo cyose cyangwa bizanwa nibintu bimwe.

Ibimenyetso nibimenyetso bya pheochromocytoma na paraganglioma bishobora kubaho mugihe kimwe mubintu bikurikira kibaye:

  • Imyitozo ngororamubiri ikomeye.
  • Gukomeretsa kumubiri cyangwa kugira ibibazo byinshi byamarangamutima.
  • Kubyara.
  • Kujya munsi ya anesthesia.
  • Kubaga, harimo uburyo bwo gukuraho ikibyimba.
  • Kurya ibiryo birimo tyramine (nka vino itukura, shokora, na foromaje).

Ibizamini bisuzuma amaraso ninkari bikoreshwa mugushakisha (gushakisha) no gusuzuma pheochromocytoma na paraganglioma.

Ibizamini hamwe nuburyo bukurikira birashobora gukoreshwa:

  • Ikizamini cyumubiri namateka: Ikizamini cyumubiri kugirango ugenzure ibimenyetso rusange byubuzima, harimo no gusuzuma ibimenyetso byindwara, nkumuvuduko ukabije wamaraso cyangwa ikindi kintu cyose gisa nkidasanzwe. Hazafatwa kandi amateka yubuzima bwumurwayi nindwara zashize hamwe nubuvuzi.
  • Kwipimisha inkari amasaha 24 : Ikizamini gikusanyirizwamo inkari amasaha 24 kugirango bapime urugero rwa catecholamine mu nkari. Ibintu biterwa no gusenyuka kwa catecholamine nabyo birapimwa. Umubare udasanzwe (uri hejuru cyangwa uri munsi yubusanzwe) ibintu bishobora kuba ikimenyetso cyindwara mumubiri cyangwa tissue ituma. Umubare urenze-usanzwe wa catecholamine ushobora kuba ikimenyetso cya pheochromocytoma.
  • Amaraso ya catecholamine yiga: Uburyo bwo gusuzuma urugero rwamaraso kugirango bapime ingano ya catecholamine isohoka mumaraso. Ibintu biterwa no gusenyuka kwa catecholamine nabyo birapimwa. Umubare udasanzwe (urenze cyangwa uri munsi yubusanzwe) ibintu bishobora kuba ikimenyetso cyindwara mumubiri cyangwa tissue ituma. Umubare urenze-usanzwe wa catecholamine ushobora kuba ikimenyetso cya pheochromocytoma.
  • CT scan (CAT scan): Uburyo bukora urukurikirane rwamashusho arambuye yibice biri mumubiri, nk'ijosi, igituza, inda, na pelvis, byafashwe muburyo butandukanye. Amashusho yakozwe na mudasobwa ihujwe na mashini ya x-ray. Irangi rishobora guterwa mumitsi cyangwa kumirwa kugirango bifashe ingingo cyangwa ingirangingo kugaragara neza. Ubu buryo nabwo bwitwa computing tomografiya, tomografiya ya mudasobwa, cyangwa mudasobwa ya axial tomografiya.
  • MRI . Ubu buryo bwitwa kandi magnetic magnetic resonance imaging (NMRI).

Ubujyanama bwa genetike buri muri gahunda yo kuvura abarwayi bafite pheochromocytoma cyangwa paraganglioma.

Abarwayi bose basuzumwe na pheochromocytoma cyangwa paraganglioma bagomba kugira inama zijyanye na genetike kugirango bamenye ibyago byabo byo kwandura syndrome yarazwe hamwe na kanseri zifitanye isano.

Kwipimisha genetike birashobora gusabwa numujyanama wa geneti kubarwayi bafite:

  • Kugira amateka yumuntu ku giti cye cyangwa mumiryango yimico ifitanye isano na pheochromocytoma yarazwe cyangwa syndrome ya paraganglioma.
  • Kugira ibibyimba muri glande zombi.
  • Kugira ikibyimba kirenze kimwe muri glande imwe ya adrenal.
  • Kugira ibimenyetso cyangwa ibimenyetso bya catecholamine yinyongera irekurwa mumaraso cyangwa paraganglioma mbi (kanseri).
  • Basuzumwa mbere yimyaka 40.

Kwipimisha genetike rimwe na rimwe birasabwa abarwayi bafite pheochromocytoma ninde:

  • Bafite imyaka 40 kugeza kuri 50.
  • Kugira ikibyimba muri glande imwe ya adrenal.
  • Ntugire amateka yumuntu cyangwa umuryango wa syndrome yarazwe.

Iyo impinduka zimwe na zimwe zabonetse mugihe cyo kwipimisha geneti, ikizamini gisanzwe gitangwa kubagize umuryango bafite ibyago ariko badafite ibimenyetso cyangwa ibimenyetso.

Kwipimisha genetike ntabwo byemewe kubarwayi barengeje imyaka 50.

Ibintu bimwe bigira ingaruka kubitekerezo (amahirwe yo gukira) hamwe nuburyo bwo kuvura.

Kumenyekanisha (amahirwe yo gukira) hamwe nuburyo bwo kuvura biterwa nibi bikurikira:

  • Niba ikibyimba ari cyiza cyangwa kibi.
  • Niba ikibyimba kiri ahantu hamwe gusa cyangwa cyakwirakwiriye ahandi mumubiri.
  • Niba hari ibimenyetso cyangwa ibimenyetso byatewe nubunini burenze-busanzwe bwa catecholamine.
  • Niba ikibyimba kimaze gupimwa cyangwa cyongeye kugaruka (garuka).

Icyiciro cya Pheochromocytoma na Paraganglioma

INGINGO Z'INGENZI

  • Nyuma yo gupimwa pheochromocytoma na paraganglioma, hakorwa ibizamini kugirango hamenyekane niba ikibyimba cyakwirakwiriye mu bindi bice by'umubiri.
  • Hariho uburyo butatu kanseri ikwirakwira mu mubiri.
  • Kanseri irashobora gukwirakwira aho yatangiriye no mu bindi bice byumubiri.
  • Nta sisitemu isanzwe yo kubika pheochromocytoma na paraganglioma.
  • Pheochromocytoma na paraganglioma bisobanurwa nkibisanzwe, uturere, cyangwa metastatike.
  • Pheochromocytoma yaho na paraganglioma
  • Pheochromocytoma yo mu karere na paraganglioma
  • Pheochromocytoma ya metastatike na paraganglioma

Nyuma yo gupimwa pheochromocytoma na paraganglioma, hakorwa ibizamini kugirango hamenyekane niba ikibyimba cyakwirakwiriye mu bindi bice by'umubiri.

Ingano cyangwa ikwirakwizwa rya kanseri mubisanzwe bisobanurwa nkicyiciro. Ni ngombwa kumenya niba kanseri yarakwirakwiriye mu rwego rwo gutegura imiti. Ibizamini hamwe nuburyo bukurikira birashobora gukoreshwa kugirango hamenyekane niba ikibyimba cyakwirakwiriye mu bindi bice byumubiri:

  • CT scan (CAT scan): Uburyo bukora urukurikirane rwamashusho arambuye yibice biri mumubiri, nk'ijosi, igituza, inda, na pelvis, byafashwe muburyo butandukanye. Amashusho yakozwe na mudasobwa ihujwe na mashini ya x-ray. Irangi rishobora guterwa mumitsi cyangwa kumirwa kugirango bifashe ingingo cyangwa ingirangingo kugaragara neza. Inda na pelvis byashushanijwe kugirango bamenye ibibyimba birekura catecholamine. Ubu buryo nabwo bwitwa computing tomografiya, tomografiya ya mudasobwa, cyangwa mudasobwa ya axial tomografiya.
  • MRI . Ubu buryo bwitwa kandi magnetic magnetic resonance imaging (NMRI).
  • MIBG scan: Uburyo bukoreshwa mugushakisha ibibyimba bya neuroendocrine, nka pheochromocytoma na paraganglioma. Umubare muto cyane wibintu byitwa radioactive MIBG byatewe mumitsi kandi bikanyura mumaraso. Utugingo ngengabuzima twa Neuroendocrine dufata radio MIBG kandi ikamenyekana na scaneri. Gusikana birashobora gufatwa muminsi 1-3. Umuti wa iyode urashobora gutangwa mbere cyangwa mugihe cyizamini kugirango glande ya tiroyide idakira cyane MIBG.
  • scan: Ubwoko bwa radionuclide scan ikoreshwa mugushakisha ibibyimba bimwe na bimwe, harimo ibibyimba birekura catecholamine. Umubare muto cyane wa radioaktiw (imisemburo ifata ibibyimba bimwe na bimwe) yatewe mumitsi kandi ikanyura mumaraso. Iradiyo ifata ikibyimba na kamera idasanzwe igaragaza radioactivite ikoreshwa kugirango yerekane aho ibibyimba biri mumubiri.
  • FDG-PET scan (fluorodeoxyglucose-positron emission tomografi scan): Uburyo bwo kubona selile yibibyimba bibi mumubiri. Umubare muto wa FDG, ubwoko bwa glucose ikora radio (isukari), batewe mumitsi. PET scaneri izenguruka umubiri kandi ikora ishusho yerekana aho glucose ikoreshwa mumubiri. Utugingo ngengabuzima twibibyimba twerekana neza cyane ku ishusho kuko zikora cyane kandi zifata glucose nyinshi kuruta selile zisanzwe.

Hariho uburyo butatu kanseri ikwirakwira mu mubiri.

Kanseri irashobora gukwirakwira binyuze mu ngingo, sisitemu ya lymph, n'amaraso:

  • Tissue. Kanseri ikwirakwira aho yatangiriye ikurira mu turere twegereye.
  • Sisitemu ya Lymph. Kanseri ikwirakwira aho yatangiriye yinjira muri sisitemu ya lymph. Kanseri inyura mu mitsi ya lymph igana mu bindi bice by'umubiri.
  • Amaraso. Kanseri ikwirakwira aho yatangiriye yinjira mu maraso. Kanseri inyura mu mitsi y'amaraso igana mu bindi bice by'umubiri.

Kanseri irashobora gukwirakwira aho yatangiriye no mu bindi bice byumubiri.

Iyo kanseri ikwirakwira mu kindi gice cy'umubiri, yitwa metastasis. Ingirabuzimafatizo za kanseri zitandukana aho zatangiriye (ikibyimba kibanza) zikanyura muri sisitemu ya lymph cyangwa maraso.

  • Sisitemu ya Lymph. Kanseri yinjira muri sisitemu ya lymph, ikanyura mu mitsi ya lymph, igakora ikibyimba (ikibyimba metastatike) mu kindi gice cy'umubiri.
  • Amaraso. Kanseri yinjira mu maraso, ikanyura mu mitsi y'amaraso, igakora ikibyimba (ikibyimba metastatike) mu kindi gice cy'umubiri.

Ikibyimba metastatike nubwoko bumwe bwa kanseri nkibibyimba byibanze. Kurugero, niba pheochromocytoma ikwirakwira kumagufa, kanseri ya kanseri mumagufwa ni selile pheochromocytoma. Indwara ni metheque pheochromocytoma, ntabwo ari kanseri yamagufa.

Nta sisitemu isanzwe yo kubika pheochromocytoma na paraganglioma.

Pheochromocytoma na paraganglioma bisobanurwa nkibisanzwe, uturere, cyangwa metastatike.

Pheochromocytoma yaho na paraganglioma

Ikibyimba kiboneka muri glande imwe cyangwa zombi (pheochromocytoma) cyangwa mukarere kamwe gusa (paraganglioma).

Pheochromocytoma yo mu karere na paraganglioma

Kanseri yakwirakwiriye kuri lymph node cyangwa izindi nyama hafi aho ikibyimba cyatangiriye.

Pheochromocytoma ya metastatike na paraganglioma

Kanseri yakwirakwiriye mu bindi bice by'umubiri, nk'umwijima, ibihaha, amagufwa, cyangwa lymph node ya kure.

Pheochromocytoma isubirwamo na Paraganglioma

Pheochromocytoma cyangwa paraganglioma isubirwamo ni kanseri yagarutse (garuka) nyuma yo kuvurwa. Kanseri irashobora kugaruka ahantu hamwe cyangwa mu kindi gice cyumubiri.

Incamake yo kuvura

INGINGO Z'INGENZI

  • Hariho uburyo butandukanye bwo kuvura abarwayi bafite pheochromocytoma cyangwa paraganglioma.
  • Abarwayi bafite pheochromocytoma na paraganglioma itera ibimenyetso cyangwa ibimenyetso bavurwa hakoreshejwe imiti.
  • Ubwoko butandatu bwo kuvura busanzwe bukoreshwa:
  • Kubaga
  • Imiti ivura imirasire
  • Chimoterapi
  • Ubuvuzi
  • Ubuvuzi bwa Embolisation
  • Ubuvuzi bugamije
  • Ubwoko bushya bwo kuvura burimo kugeragezwa mubigeragezo byamavuriro.
  • Umuti wa pheochromocytoma na paraganglioma urashobora gutera ingaruka mbi.
  • Abarwayi barashobora kwifuza gutekereza kubijyanye no kwipimisha kwa muganga.
  • Abarwayi barashobora kwipimisha kwa muganga mbere, mugihe, cyangwa nyuma yo gutangira kuvura kanseri.
  • Ibizamini byo gukurikirana bizakenerwa.

Hariho uburyo butandukanye bwo kuvura abarwayi bafite pheochromocytoma cyangwa paraganglioma.

Ubwoko butandukanye bwo kuvura burahari kubarwayi barwaye pheochromocytoma cyangwa paraganglioma. Bumwe mu buryo busanzwe (ubuvuzi bukoreshwa ubu), kandi bumwe burimo kugeragezwa mubigeragezo byamavuriro. Ikigeragezo kivura ni ubushakashatsi bwakozwe bugamije gufasha kunoza imiti igezweho cyangwa kubona amakuru ku buvuzi bushya ku barwayi ba kanseri. Iyo ibizamini byo kwa muganga byerekana ko ubuvuzi bushya buruta ubuvuzi busanzwe, ubuvuzi bushya bushobora kuba ubuvuzi busanzwe. Abarwayi barashobora kwifuza gutekereza kubijyanye no kwipimisha kwa muganga. Ibigeragezo bimwe na bimwe bivura abarwayi batatangiye kwivuza

Abarwayi bafite pheochromocytoma na paraganglioma itera ibimenyetso cyangwa ibimenyetso bavurwa hakoreshejwe imiti.

Ubuvuzi bwibiyobyabwenge butangira iyo pheochromocytoma cyangwa paraganglioma isuzumwe. Ibi bishobora kubamo:

  • Ibiyobyabwenge bituma umuvuduko wamaraso usanzwe. Kurugero, ubwoko bumwe bwibiyobyabwenge byitwa alpha-blokers bihagarika noradrenaline gukora imiyoboro mito mito. Kugumisha imiyoboro y'amaraso gufungura no kuruhuka byongera umuvuduko wamaraso kandi bigabanya umuvuduko wamaraso.
  • Ibiyobyabwenge bituma umutima utera bisanzwe. Kurugero, ubwoko bumwe bwibiyobyabwenge byitwa beta-blokers bihagarika ingaruka za noradrenaline nyinshi kandi bigabanya umuvuduko wumutima.
  • Ibiyobyabwenge bibuza ingaruka za hormone zidasanzwe zakozwe na glande ya adrenal.

Ubuvuzi bwibiyobyabwenge butangwa mugihe cyicyumweru kimwe cyangwa bitatu mbere yo kubagwa.

Ubwoko butandatu bwo kuvura busanzwe bukoreshwa:

Kubaga

Kubaga kugirango ukureho pheochromocytoma mubisanzwe ni adrenalectomie (kuvanaho glande imwe cyangwa zombi). Muri iki gihe cyo kubagwa, hazasuzumwa uduce na lymph node imbere munda kandi niba ikibyimba kimaze gukwirakwira, izo nyama nazo zishobora kuvaho. Ibiyobyabwenge birashobora gutangwa mbere, mugihe, na nyuma yo kubagwa kugirango umuvuduko wamaraso hamwe n umuvuduko wumutima.

Nyuma yo kubagwa kugirango bakureho ikibyimba, harasuzumwa urugero rwa catecholamine mumaraso cyangwa inkari. Urwego rusanzwe rwa catecholamine ni ikimenyetso cyerekana ko selile zose za pheochromocytoma zavanyweho.

Niba glande zombi zivanyweho, hakenewe imiti myinshi yo kuvura imisemburo yo gusimbuza imisemburo ikorwa na glande ya adrenal.

Imiti ivura imirasire

Imishwarara ivura ni imiti ikoresha kanseri ikoresha ingufu nyinshi za x-imirasire cyangwa ubundi bwoko bwimirasire yica kanseri cyangwa ikabuza gukura. Hariho ubwoko bubiri bwo kuvura imirasire:

  • Imiti ivura hanze ikoresha imashini hanze yumubiri kugirango yohereze imirasire kuri kanseri.
  • Imiti ivura imbere ikoresha ibintu bifata radiyo bifunze inshinge, imbuto, insinga, cyangwa catheteri bishyirwa muri kanseri cyangwa hafi yayo.

Uburyo imiti ivura imirasire itangwa biterwa n'ubwoko bwa kanseri ivurwa kandi niba ari iy'akarere, uturere, metastatike, cyangwa isubiramo. Ubuvuzi bwimirasire yo hanze hamwe nubuvuzi 131I-MIBG bukoreshwa mukuvura pheochromocytoma.

Pheochromocytoma rimwe na rimwe ivurwa hamwe na 131I-MIBG, itwara imirasire mu ngirabuzimafatizo. 131I-MIBG ni ikintu gikoresha radiyo ikusanya mu bwoko bumwe na bumwe bw'utugingo ngengabuzima, ikabica hamwe n'imirasire yatanzwe. 131I-MIBG itangwa no gushiramo. Pheochromocytoma yose ntabwo ifata 131I-MIBG, kubwibyo ikizamini kibanza kubanza gusuzuma niba mbere yuko imiti itangira.

Chimoterapi

Chimoterapi ni umuti wa kanseri ukoresha ibiyobyabwenge kugirango uhagarike imikurire ya kanseri, haba mu kwica selile cyangwa kubabuza gutandukana. Iyo chimiotherapie ifashwe numunwa cyangwa igaterwa mumitsi cyangwa imitsi, imiti yinjira mumaraso kandi irashobora kugera kanseri ya kanseri mumubiri (chimiotherapie sisitemu). Iyo chimiotherapie ishyizwe mumazi yubwonko, urugingo, cyangwa umwobo wumubiri nkinda, imiti yibasira kanseri ya kanseri muri utwo turere (chimiotherapie yo mukarere). Imiti ya chimiotherapie ni imiti ikoresheje imiti irenze imwe ya anticancer. Uburyo chimiotherapie itangwa biterwa n'ubwoko bwa kanseri ivurwa kandi niba ari iy'akarere, uturere, metastatike, cyangwa isubiramo.

Ubuvuzi

Gukuraho ni uburyo bwo gukuraho cyangwa gusenya igice cyumubiri cyangwa tissue cyangwa imikorere yacyo. Ubuvuzi bwa Ablation bukoreshwa mu gufasha kwica selile zirimo:

  • Gukuraho Radiofrequency: Uburyo bukoresha umurongo wa radio kugirango ushushe kandi usenye selile zidasanzwe. Iradiyo iranyura muri electrode (ibikoresho bito bitwara amashanyarazi). Gukuraho radiofrequency birashobora gukoreshwa mu kuvura kanseri nibindi bihe.
  • Cryoablation: Uburyo bukonjesha tissue kugirango isenye selile zidasanzwe. Amazi ya azote cyangwa dioxyde de carbone ikoreshwa muguhagarika ingirangingo.

Ubuvuzi bwa Embolisation

Ubuvuzi bwa Embolisation nubuvuzi bwo guhagarika imiyoboro iganisha kuri glande ya adrenal. Guhagarika gutembera kw'amaraso muri glande ya adrenal bifasha kwica kanseri ikura aho.

Ubuvuzi bugamije

Ubuvuzi bugamije ni ubuvuzi bukoresha ibiyobyabwenge cyangwa ibindi bintu kugirango umenye kandi utere kanseri yihariye itangiza ingirabuzimafatizo zisanzwe. Ubuvuzi bugamije gukoreshwa mu kuvura metheque na pheochromocytoma isubirwamo.

Sunitinib (ubwoko bwa tyrosine kinase inhibitor) nubuvuzi bushya burimo kwigwa kuri pheochromocytoma metastatike. Ubuvuzi bwa Tyrosine kinase inhibitor ni ubwoko bwubuvuzi bugamije guhagarika ibimenyetso bikenewe kugirango ibibyimba bikure.

Ubwoko bushya bwo kuvura burimo kugeragezwa mubigeragezo byamavuriro.

Amakuru yerekeye ibizamini byamavuriro araboneka kurubuga rwa NCI.

Umuti wa pheochromocytoma na paraganglioma urashobora gutera ingaruka mbi.

Kumakuru yingaruka ziterwa no kuvura kanseri, reba urupapuro rwuruhande rwacu.

Abarwayi barashobora kwifuza gutekereza kubijyanye no kwipimisha kwa muganga.

Ku barwayi bamwe, kwitabira ikizamini cyamavuriro birashobora kuba uburyo bwiza bwo kuvura. Ibigeragezo bivura biri mubikorwa byubushakashatsi bwa kanseri. Igeragezwa rya Clinical rikorwa kugirango hamenyekane niba imiti mishya ya kanseri itekanye kandi ifite akamaro cyangwa nziza kuruta ubuvuzi busanzwe.

Benshi mubuvuzi busanzwe bwa kanseri bushingiye kubigeragezo byambere byubuvuzi. Abarwayi bitabiriye kwipimisha barashobora kuvurwa bisanzwe cyangwa kuba mubambere bahawe imiti mishya.

Abarwayi bitabira ibizamini byo kwa muganga nabo bafasha kunoza uburyo kanseri izavurwa mugihe kizaza. Nubwo ibigeragezo bivura bitaganisha ku buvuzi bushya, akenshi basubiza ibibazo byingenzi kandi bigafasha gutera imbere ubushakashatsi.

Abarwayi barashobora kwipimisha kwa muganga mbere, mugihe, cyangwa nyuma yo gutangira kuvura kanseri.

Igeragezwa rimwe na rimwe ririmo abarwayi bataravurwa. Ibindi bigeragezo bipima abarwayi bafite kanseri itameze neza. Hariho kandi ibizamini byo kwa muganga bipima uburyo bushya bwo guhagarika kanseri kongera kugaruka (kugaruka) cyangwa kugabanya ingaruka zo kuvura kanseri.

Igeragezwa rya Clinical ririmo kubera mu bice byinshi by'igihugu. Amakuru yerekeye ibizamini byamavuriro ashyigikiwe na NCI urashobora kubisanga kurubuga rwa NCI. Ibizamini bya Clinical bishyigikiwe nandi mashyirahamwe murashobora kubisanga kurubuga rwa ClinicalTrials.gov.

Ibizamini byo gukurikirana bizakenerwa.

Bimwe mubizamini byakozwe mugupima kanseri cyangwa kumenya urugero rwa kanseri bishobora gusubirwamo. Ibizamini bimwe bizasubirwamo kugirango harebwe uburyo ubuvuzi bukora neza. Ibyemezo bijyanye no gukomeza, guhindura, cyangwa guhagarika ubuvuzi bizashingira kubisubizo by'ibi bizamini.

Bimwe mubizamini bizakomeza gukorwa buri gihe nyuma yubuvuzi burangiye. Ibisubizo by'ibi bizamini birashobora kwerekana niba ubuzima bwawe bwarahindutse cyangwa niba kanseri yarongeye (garuka). Ibi bizamini rimwe na rimwe byitwa gukurikirana-ibizamini.

Ku barwayi barwaye pheochromocytoma cyangwa paraganglioma itera ibimenyetso, urugero rwa catecholamine mumaraso ninkari bizasuzumwa buri gihe. Urwego rwa Catecholamine ruri hejuru yubusanzwe rushobora kuba ikimenyetso cyuko kanseri yagarutse.

Ku barwayi barwaye paraganglioma idatera ibimenyetso, ibizamini byo gukurikirana nka CT, MRI, cyangwa MIBG scan bigomba gukorwa buri mwaka.

Ku barwayi bafite pheochromocytoma yarazwe, urugero rwa catecholamine mu maraso n'inkari bizasuzumwa buri gihe. Ibindi bizamini byo gusuzuma bizakorwa kugirango harebwe ibindi bibyimba bifitanye isano na syndrome twarazwe.

Vugana na muganga wawe kubyerekeye ibizamini bigomba gukorwa ninshuro. Abarwayi bafite pheochromocytoma cyangwa paraganglioma bakeneye gukurikirana ubuzima bwabo bwose.

Amahitamo yo kuvura Pheochromocytoma na Paraganglioma

Muri iki gice

  • Ahantu Pheochromocytoma na Paraganglioma
  • Umurage Pheochromocytoma
  • Pheochromocytoma yo mu karere na Paraganglioma
  • Metastatike Pheochromocytoma na Paraganglioma
  • Pheochromocytoma isubirwamo na Paraganglioma

Kumakuru yerekeye imiti yavuzwe hepfo, reba igice cyo kuvura.

Ahantu Pheochromocytoma na Paraganglioma

Kuvura benigne pheochromocytoma cyangwa paraganglioma mubisanzwe ni kubaga kugirango bakureho ikibyimba burundu. Niba ikibyimba kiri muri glande ya adrenal, glande yose ya adrenal ikurwaho.

Koresha ubushakashatsi bwamavuriro kugirango ushakishe NCI ifashwa na kanseri ivura abarwayi. Urashobora gushakisha ibigeragezo ukurikije ubwoko bwa kanseri, imyaka yumurwayi, n’aho ibizamini bikorerwa. Amakuru rusange yerekeye ibizamini byamavuriro nayo arahari.

Umurage Pheochromocytoma

Ku barwayi bafite pheochromocytoma yarazwe ifitanye isano na endoprine neoplasia nyinshi (MEN2) cyangwa syndrome ya von Hippel-Lindau (VHL), ibibyimba bikunze kubaho muri glande zombi. Ibibyimba mubisanzwe ni byiza.

  • Umuti wa pheochromocytoma warazwe ukora muri glande imwe ya adrenal ni kubaga kugirango ukureho glande burundu. Kubaga birashobora gufasha abarwayi kwirinda imiti yo gusimbuza imisemburo ya steroid ubuzima bwabo bwose hamwe no kubura adrenal ikabije.
  • Umuti wa pheochromocytoma warazwe uba muri glande ya adrenal cyangwa nyuma yaho muri glande isigaye irashobora kubagwa kugirango ukureho ikibyimba hamwe nuduce duto dusanzwe muri cortex ya adrenal bishoboka. Kubaga bishobora gufasha abarwayi kwirinda imiti isimbura ubuzima bwa hormone hamwe nibibazo byubuzima bitewe no gutakaza imisemburo ikorwa na glande ya adrenal.

Pheochromocytoma yo mu karere na Paraganglioma

Kuvura pheochromocytoma cyangwa paraganglioma yakwirakwiriye mu ngingo zegeranye cyangwa lymph node ni ukubaga gukuraho ikibyimba burundu. Ibice hafi ya kanseri yakwirakwiriye, nk'impyiko, umwijima, igice cy'imiyoboro minini y'amaraso, hamwe na lymph node, na byo bishobora kuvaho.

Koresha ubushakashatsi bwamavuriro kugirango ushakishe NCI ifashwa na kanseri ivura abarwayi. Urashobora gushakisha ibigeragezo ukurikije ubwoko bwa kanseri, imyaka yumurwayi, n’aho ibizamini bikorerwa. Amakuru rusange yerekeye ibizamini byamavuriro nayo arahari.

Metastatike Pheochromocytoma na Paraganglioma

Kuvura pheochromocytoma metastatike cyangwa paraganglioma bishobora kuba bikubiyemo ibi bikurikira:

  • Kubaga kugirango ukureho burundu kanseri, harimo ibibyimba byakwirakwiriye mu bice bya kure by'umubiri.
  • Ubuvuzi bwa Palliative, kugabanya ibimenyetso no kuzamura imibereho, harimo:
  • Kubaga kugirango ukureho kanseri ishoboka.
  • Ubuvuzi bwa chimiotherapie.
  • Imiti ivura imirasire hamwe na 131I-MIBG.
  • Imishwarara yo hanze ivura ahantu (nk'amagufwa) aho kanseri yakwirakwiriye kandi ntishobora gukurwaho no kubagwa.
  • Embolisation (kuvura kugirango uhagarike imiyoboro itanga amaraso kumibyimba).
  • Ubuvuzi bwa Ablation ukoresheje radiofrequency ablation cyangwa cryoablation kubyimba umwijima cyangwa amagufwa.
  • Igeragezwa rya clinique yubuvuzi bugamije hamwe na tyrosine kinase inhibitor.
  • Igeragezwa rya clinique yo kuvura imirasire yimbere ukoresheje ibintu bishya bya radio.

Koresha ubushakashatsi bwamavuriro kugirango ushakishe NCI ifashwa na kanseri ivura abarwayi. Urashobora gushakisha ibigeragezo ukurikije ubwoko bwa kanseri, imyaka yumurwayi, n’aho ibizamini bikorerwa. Amakuru rusange yerekeye ibizamini byamavuriro nayo arahari.

Pheochromocytoma isubirwamo na Paraganglioma

Ubuvuzi bwa pheochromocytoma cyangwa paraganglioma bushobora kubamo ibi bikurikira:

  • Kubaga kugirango ukureho burundu kanseri.
  • Iyo kubagwa kugirango ukureho kanseri bidashoboka, kuvura palliative kugabanya ibimenyetso no kuzamura imibereho, harimo:
  • Ubuvuzi bwa chimiotherapie.
  • Ubuvuzi bugamije.
  • Ubuvuzi bwimirasire ukoresheje 131I-MIBG.
  • Imishwarara yo hanze ivura ahantu (nk'amagufwa) aho kanseri yakwirakwiriye kandi ntishobora gukurwaho no kubagwa.
  • Ubuvuzi bwo gukuraho ukoresheje radiofrequency ablation cyangwa cryoablation.

Koresha ubushakashatsi bwamavuriro kugirango ushakishe NCI ifashwa na kanseri ivura abarwayi. Urashobora gushakisha ibigeragezo ukurikije ubwoko bwa kanseri, imyaka yumurwayi, n’aho ibizamini bikorerwa. Amakuru rusange yerekeye ibizamini byamavuriro nayo arahari.

Pheochromocytoma Mugihe cyo Gutwita

INGINGO Z'INGENZI

  • Abagore batwite bafite pheochromocytoma bakeneye kwitabwaho bidasanzwe.
  • Kuvura abagore batwite barwaye pheochromocytoma birashobora kubagwa.

Kumakuru yerekeye imiti yavuzwe hepfo, reba igice cyo kuvura.

Abagore batwite bafite pheochromocytoma bakeneye kwitabwaho bidasanzwe.

Nubwo bidakunze kugaragara mugihe cyo gutwita, pheochromocytoma irashobora kuba ikomeye cyane kubabyeyi no kuvuka. Abagore bafite ibyago byinshi byo kwandura pheochromocytoma bagomba kwipimisha mbere yo kubyara. Abagore batwite bafite pheochromocytoma bagomba kuvurwa nitsinda ryabaganga ninzobere muri ubu buryo bwo kwita.

Ibimenyetso bya pheochromocytoma mugihe utwite bishobora kubamo kimwe muribi bikurikira:

  • Umuvuduko ukabije wamaraso mugihe cyamezi 3 yambere yo gutwita.
  • Ibihe bitunguranye byumuvuduko ukabije wamaraso.
  • Umuvuduko ukabije wamaraso utoroshye kuvura.

Mu gusuzuma indwara ya pheochromocytoma ku bagore batwite harimo no gupima urugero rwa catecholamine mu maraso no mu nkari. Reba amakuru rusange kugirango ubone ibisobanuro byibi bizamini. MRI irashobora gukorwa kugirango ibone neza ibibyimba ku bagore batwite kuko idashyira akayoya ku mirasire.

Kuvura abagore batwite barwaye pheochromocytoma birashobora kubagwa.

Kuvura pheochromocytoma mugihe utwite bishobora kuba bikubiyemo ibi bikurikira:

  • Kubaga kugirango ukureho burundu kanseri mugihembwe cya kabiri (icya kane kugeza ukwezi kwa gatandatu gutwita).
  • Kubagwa kugirango ukureho kanseri burundu hamwe no kubyara uruhinja kubice bya cesarien.

Kumenya byinshi kuri Pheochromocytoma na Paraganglioma

Ushaka amakuru menshi yikigo cyigihugu cya kanseri kubyerekeye pheochromocytoma na paraganglioma, reba ibi bikurikira:

  • Pheochromocytoma na Paraganglioma Urupapuro rwurugo
  • Umwana Pheochromocytoma no kuvura Paraganglioma
  • Kubaga mu kuvura Kanseri: Ibibazo n'ibisubizo
  • Intego zo kuvura Kanseri
  • Kwipimisha genetike ya Syndromes Yarazwe Kanseri

Kumakuru rusange ya kanseri nibindi bikoresho biva mu kigo cyigihugu cya kanseri, reba ibi bikurikira:

  • Ibyerekeye Kanseri
  • Gutegura
  • Chimiotherapie nawe: Inkunga kubantu barwaye Kanseri
  • Ubuvuzi bwimirasire nawe: Inkunga kubantu barwaye Kanseri
  • Guhangana na Kanseri
  • Ibibazo byo Kubaza Muganga wawe kuri Kanseri
  • Abacitse ku icumu n'abarezi


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