Types/myeloproliferative/patient/chronic-treatment-pdq

Umuti wa karande Myeloproliferative Neoplasms (®) –Umurwayi

Amakuru Rusange Yerekeye Myeloproliferative Neoplasms idakira

INGINGO Z'INGENZI

• Myeloproliferative neoplasms ni itsinda ryindwara aho igufwa ryamagufa rikora selile nyinshi zitukura, selile yera, cyangwa platine.

• Hariho ubwoko 6 bwa myeloproliferative neoplasms.

• Ibizamini bisuzuma amaraso n'amagufa bikoreshwa mugupima indwara ya myeloproliferative idakira.

Myeloproliferative neoplasms ni itsinda ryindwara aho igufwa ryamagufa rikora selile nyinshi zitukura, selile yera, cyangwa platine.

Mubisanzwe, igufwa ryamagufa ritera ingirangingo zamaraso (selile zidakuze) zihinduka selile yamaraso ikuze mugihe runaka.

Anatomy yamagufwa. Igufwa rigizwe n'amagufwa magufi, amagufwa ya spongy, n'amagufwa. Amagufwa magufi agize igice cyinyuma cyamagufwa. Amagufwa ya spongy aboneka cyane kumpera yamagufa kandi arimo umusemburo utukura. Amagufwa yo mu magufa aboneka hagati yamagufwa menshi kandi afite imiyoboro myinshi yamaraso. Hariho ubwoko bubiri bwamagufwa: umutuku numuhondo. Umutuku utukura urimo ingirangingo z'amaraso zishobora guhinduka selile zitukura, selile yera, cyangwa platine. Umuhondo wumuhondo ugizwe ahanini namavuta.

Ingirabuzimafatizo y'amaraso irashobora guhinduka myeloid stem selile cyangwa lymphoide stem selile. Lymphoide stem selile iba selile yera. Ingirabuzimafatizo ya myeloid ihinduka bumwe mu bwoko butatu bw'amaraso akuze:

• Uturemangingo twamaraso dutukura dutwara ogisijeni nibindi bintu mubice byose byumubiri.

• Utugingo ngengabuzima twera turwanya indwara n'indwara.

• Amashanyarazi akora amaraso kugirango areke kuva amaraso.

Gukura kw'amaraso. Ingirabuzimafatizo y'amaraso inyura mu ntambwe nyinshi kugirango ihinduke selile itukura, platine, cyangwa selile yera.

Muri myeloproliferative neoplasms, ingirabuzimafatizo nyinshi zamaraso ziba ubwoko bumwe cyangwa bwinshi bwingirabuzimafatizo. Ubusanzwe neoplasme igenda iba mibi buhoro buhoro uko umubare w'uturemangingo twinshi twiyongera.

Hariho ubwoko 6 bwa myeloproliferative neoplasms.

Ubwoko bwa myeloproliferative neoplasm bushingiye ku kuba hakorwa selile nyinshi zitukura, selile yera, cyangwa platine. Rimwe na rimwe, umubiri uzakora ibintu byinshi birenze ubwoko bumwe bwamaraso, ariko mubisanzwe ubwoko bumwe bwamaraso bugira ingaruka kurenza izindi. Indwara ya myeloproliferative idakira ikubiyemo ubwoko 6 bukurikira:

• Indwara ya leukemia idakira.

• Polycythemia vera.

• Myelofibrosis yibanze (nanone yitwa idiopathic myelofibrosis idakira).

• Ibyingenzi byingenzi.

• Indwara ya leutemiya idakira.

• Indwara ya eosinofilique idakira.

Ubu bwoko bwasobanuwe hano hepfo. Indwara ya myeloproliferative idakira rimwe na rimwe iba leukemia ikaze, aho hakorwa uturemangingo twinshi twamaraso adasanzwe.

Ibizamini bisuzuma amaraso n'amagufa bikoreshwa mugupima indwara ya myeloproliferative idakira.

Ibizamini hamwe nuburyo bukurikira birashobora gukoreshwa:

• Ikizamini cyumubiri namateka yubuzima: Ikizamini cyumubiri kugirango ugenzure ibimenyetso rusange byubuzima, harimo no gusuzuma ibimenyetso byindwara, nkibibyimba cyangwa ikindi kintu cyose gisa nkidasanzwe. Hazafatwa kandi amateka yubuzima bwumurwayi nindwara zashize hamwe nubuvuzi.

• Umubare wuzuye wamaraso (CBC) ufite itandukaniro: Uburyo bwo gukuramo urugero rwamaraso no gusuzuma ibi bikurikira:

• Umubare w'uturemangingo tw'amaraso atukura na platine.

• Umubare nubwoko bwingirangingo zamaraso yera.

• Ingano ya hemoglobine (proteyine itwara ogisijeni) mu ngirangingo z'amaraso atukura.

• Igice cyicyitegererezo cyamaraso kigizwe ningirabuzimafatizo zitukura.

Kubara amaraso yuzuye (CBC). Amaraso akusanywa no kwinjiza inshinge mumitsi no kwemerera amaraso gutembera mumiyoboro. Icyitegererezo cyamaraso cyoherezwa muri laboratoire hanyuma selile zitukura, selile yera, na platine zirabaze. CBC ikoreshwa mugupima, gusuzuma, no gukurikirana ibintu byinshi bitandukanye.

• Amaraso ya periferique: Uburyo bwo gusuzuma urugero rwamaraso kuri ibi bikurikira:

• Niba hari selile zitukura zimeze nkamarira.

• Umubare nubwoko bwingirabuzimafatizo zera.

• Umubare wa platine.

• Niba hari selile ziturika.

• Ubushakashatsi bwa chimie yamaraso: Uburyo bwo gusuzuma urugero rwamaraso kugirango bapime urugero rwibintu bimwe na bimwe bisohoka mumaraso ningingo nuduce twumubiri. Umubare udasanzwe (uri hejuru cyangwa uri munsi yubusanzwe) ibintu bishobora kuba ikimenyetso cyindwara.

• Amagufa ya marrow aspiration na biopsy: Gukuraho igufwa ryamagufa, amaraso, nigice gito cyamagufwa winjiza urushinge rudafite epfo na ruguru cyangwa amabere. Inzobere mu by'indwara ireba amagufwa, amaraso, n'amagufwa munsi ya microscope kugirango ishakishe ingirabuzimafatizo zidasanzwe.

Amagufa ya marrow icyifuzo na biopsy. Nyuma yuko agace gato k'uruhu kamaze kunanirwa, urushinge rw'amagufwa rwinjizwa mu igufwa ry'umurwayi. Ingero z'amaraso, amagufwa, n'amagufwa byavanyweho kugirango bisuzumwe kuri microscope.

• Isesengura rya Cytogenetike: Ikizamini cya laboratoire aho chromosomes yingirabuzimafatizo ziri mu cyitegererezo cy’amagufwa cyangwa amaraso zibarwa kandi zikagenzurwa niba hari impinduka, nko kuvunika, kubura, gutondekanya, cyangwa chromosomes ziyongera. Impinduka muri chromosomes zimwe zishobora kuba ikimenyetso cya kanseri. Isesengura rya Cytogenetike rikoreshwa mu gufasha gusuzuma kanseri, gutegura gahunda yo kuvura, cyangwa kumenya uburyo ubuvuzi bukora neza.

• Ikizamini cya mutation ya Gene: Ikizamini cya laboratoire cyakozwe kumagufa cyangwa kumaraso kugirango hamenyekane ihinduka ryimiterere ya gen JAK2, MPL, cyangwa CALR. Guhindura gene JAK2 bikunze kuboneka kubarwayi barwaye polycythemia vera, trombocythemia ya ngombwa, cyangwa myelofibrosis yibanze. MPL cyangwa CALR ihindagurika rya gene riboneka kubarwayi bafite trombocythemia ya ngombwa cyangwa myelofibrosis yibanze.

Indwara ya Myelogenous Leukemia

Indwara ya myelogenous leukemia idakira ni indwara ikoreramo uturemangingo twinshi twamaraso twera mumagufwa. Reba incamake ya kubijyanye no kuvura indwara ya Myelogenous Leukemia idakira kugirango umenye amakuru yo gusuzuma, kubika, no kuvura.

Polycythemia Vera

INGINGO Z'INGENZI

• Polycythemia vera ni indwara ikoreramo uturemangingo twinshi twamaraso atukura.

• Ibimenyetso bya polycythemia vera harimo kubabara umutwe no kumva wuzuye munsi yimbavu kuruhande rwibumoso.

• Ibizamini bidasanzwe byamaraso bikoreshwa mugupima polycythemia vera.

Polycythemia vera ni indwara ikoreramo uturemangingo twinshi twamaraso atukura.

Muri polycythemia vera, amaraso aba menshi hamwe na selile nyinshi zitukura. Umubare w'uturemangingo tw'amaraso yera na platine nawo urashobora kwiyongera. Utugingo ngengabuzima twiyongereye dushobora kwegeranya mu gihimba tugatera kubyimba. Umubare munini wuturemangingo twamaraso dutukura, selile yera, cyangwa platine mumaraso birashobora gutera ibibazo byo kuva amaraso kandi bigatera uturemangingo mumitsi. Ibi birashobora kongera ibyago byo guhagarara k'umutima cyangwa kurwara umutima. Ku barwayi barengeje imyaka 65 cyangwa bafite amateka yo kuva amaraso, ibyago byo guhitanwa n'indwara y'umutima ni byinshi. Abarwayi bafite ibyago byinshi byo kurwara myeloid leukemia cyangwa myelofibrosis yibanze.

Ibimenyetso bya polycythemia vera harimo kubabara umutwe no kumva wuzuye munsi yimbavu kuruhande rwibumoso.

Polycythemia vera akenshi ntabwo itera ibimenyetso cyangwa ibimenyetso hakiri kare. Irashobora kuboneka mugihe cyo kwisuzumisha bisanzwe. Ibimenyetso nibimenyetso bishobora kubaho uko umubare wamaraso wiyongera. Ibindi bintu bishobora gutera ibimenyetso nibimenyetso bimwe. Menyesha umuganga wawe niba ufite kimwe muri ibi bikurikira:

• Kumva igitutu cyangwa kuzura munsi yimbavu kuruhande rwibumoso.

• Kubabara umutwe.

• Kubona kabiri cyangwa kubona ibibara byijimye cyangwa bihumye biza kugenda.

• Kwishisha umubiri wose, cyane cyane nyuma yo kuba mumazi ashyushye cyangwa ashyushye.

• Isura itukura isa n'iyijimye cyangwa izuba.

• Intege nke.

• Kuzunguruka.

• Kugabanya ibiro nta mpamvu izwi.

Ibizamini bidasanzwe byamaraso bikoreshwa mugupima polycythemia vera.

Usibye kubara amaraso yuzuye, ibyifuzo bya bone marrow aspirasi na biopsy, hamwe nisesengura rya cytogenetike, ikizamini cya serumu erythropoietin gikoreshwa mugupima polycythemia. Muri iki kizamini, hasuzumwe urugero rwamaraso kugirango urwego rwa erythropoietin (imisemburo itera ingirabuzimafatizo nshya zitukura). Muri polycythemia vera, urwego rwa erythropoietin rwaba ruri munsi yubusanzwe kuko umubiri udakeneye gukora selile nyinshi zitukura.

Myelofibrosis

INGINGO Z'INGENZI

• Myelofibrosis yibanze nindwara aho uturemangingo twamaraso adasanzwe hamwe na fibre byubaka imbere mumitsi.

• Ibimenyetso bya myelofibrosis yibanze harimo ububabare munsi yimbavu kuruhande rwibumoso ukumva unaniwe cyane.

• Ibintu bimwe bigira ingaruka kubimenyekanisha (amahirwe yo gukira) hamwe nuburyo bwo kuvura myelofibrosis yibanze.

Myelofibrosis yibanze nindwara aho uturemangingo twamaraso adasanzwe hamwe na fibre byubaka imbere mumitsi.

Amagufwa yamagufa agizwe nuduce dukora uturemangingo twamaraso (selile yamaraso atukura, selile yera, na platine) hamwe nurubuga rwa fibre rushyigikira ingirangingo zikora amaraso. Muri myelofibrosis yibanze (nanone yitwa idiopathic myelofibrosis idakira), umubare munini wuturemangingo twamaraso duhinduka selile zidakura neza (guturika). Urubuga rwa fibre imbere mumagufwa nayo ruba rwinshi cyane (nka tissue tissue) kandi rugabanya umuvuduko wamaraso ukora ubushobozi bwo gukora selile. Ibi bitera uturemangingo dukora amaraso gukora selile nkeya kandi nkeya. Kugirango huzuzwe umubare muto w'uturemangingo twamaraso twakozwe mu magufa, umwijima nintanga bitangira gukora selile.

Ibimenyetso bya myelofibrosis yibanze harimo ububabare munsi yimbavu kuruhande rwibumoso ukumva unaniwe cyane.

Myelofibrosis yibanze ntabwo itera ibimenyetso cyangwa ibimenyetso hakiri kare. Irashobora kuboneka mugihe cyo kwisuzumisha bisanzwe. Ibimenyetso nibimenyetso bishobora guterwa na myelofibrosis yibanze cyangwa nibindi bihe. Menyesha umuganga wawe niba ufite kimwe muri ibi bikurikira:

• Kumva ububabare cyangwa kuzura munsi yimbavu kuruhande rwibumoso.

• Kumva wuzuye vuba kurenza ibisanzwe iyo urya.

• Kumva unaniwe cyane.

• Kubura umwuka.

• Gukomeretsa byoroshye cyangwa kuva amaraso.

• Petechiae (ibibara binini, umutuku, ibibara munsi yuruhu biterwa no kuva amaraso).

• Umuriro.

• Kuruha ibyuya nijoro.

• Guta ibiro.

Ibintu bimwe bigira ingaruka kubimenyekanisha (amahirwe yo gukira) hamwe nuburyo bwo kuvura myelofibrosis yibanze.

Kumenyekanisha biterwa nibi bikurikira:

• Imyaka yumurwayi.

• Umubare w'uturemangingo tw'amaraso adasanzwe adasanzwe na selile yera.

• Umubare w'iturika mu maraso.

• Niba hari impinduka zimwe muri chromosomes.

• Niba umurwayi afite ibimenyetso nkumuriro, kubira ibyuya nijoro, cyangwa kugabanya ibiro.

Ibyingenzi bya Thrombocythemia

INGINGO Z'INGENZI

• Ibyingenzi bya trombocythemia nindwara ikorwamo platine nyinshi cyane mumitsi.

• Abarwayi bafite trombocythemia ya ngombwa ntibashobora kugira ibimenyetso cyangwa ibimenyetso.

• Ibintu bimwe bigira ingaruka kumenyekanisha (amahirwe yo gukira) hamwe nuburyo bwo kuvura trombocythemia yingenzi.

Ibyingenzi bya trombocythemia nindwara ikorwamo platine nyinshi cyane mumitsi.

Ibyingenzi bya trombocythemia bitera kwiyongera bidasanzwe mumibare ya platine ikorwa mumaraso no mumagufa.

Abarwayi bafite trombocythemia ya ngombwa ntibashobora kugira ibimenyetso cyangwa ibimenyetso.

Ibyingenzi bya trombocythemia akenshi ntibitera ibimenyetso cyangwa ibimenyetso hakiri kare. Irashobora kuboneka mugihe cyo kwisuzumisha bisanzwe. Ibimenyetso nibimenyetso bishobora guterwa na trombocytopenia yingenzi cyangwa nibindi bihe. Menyesha umuganga wawe niba ufite kimwe muri ibi bikurikira:

• Kubabara umutwe.

• Gutwika cyangwa gutitira mu biganza cyangwa ibirenge.

• Umutuku n'ubushyuhe bw'amaboko cyangwa ibirenge.

• Icyerekezo cyangwa ibibazo byo kumva.

Amashanyarazi arakomeye. Iyo hari platine nyinshi cyane, zirashobora guhurira hamwe bikagora amaraso gutembera. Uturemangingo dushobora kwibumbira mu mitsi y'amaraso kandi hashobora no kwiyongera kuva amaraso. Ibi birashobora gutera ibibazo bikomeye byubuzima nka stroke cyangwa umutima.

Ibintu bimwe bigira ingaruka kumenyekanisha (amahirwe yo gukira) hamwe nuburyo bwo kuvura trombocythemia yingenzi.

Guhitamo no kuvura biterwa nibi bikurikira:

• Imyaka yumurwayi.

• Niba umurwayi afite ibimenyetso cyangwa ibimenyetso cyangwa ibindi bibazo bijyanye na trombocythemia ya ngombwa.

Indwara ya Leutemia idakira

Indwara ya neutrophilique leukemia idakira ni indwara aho ingirabuzimafatizo nyinshi zamaraso ziba ubwoko bwamaraso yera yitwa neutrophile. Neutrophile ni selile yamaraso irwanya kwandura no gusenya selile zapfuye nibintu byamahanga (nka bagiteri). Ururenda n'umwijima birashobora kubyimba kubera neutrophile idasanzwe. Indwara ya neutrophilique idakira irashobora kuguma uko yakabaye cyangwa irashobora gutera imbere vuba kuri leukemia ikaze.

Indwara ya Eosinofilike idakira

INGINGO Z'INGENZI

• Indwara ya eosinofilique idakira ni indwara ikoreramo uturemangingo twinshi twamaraso yera (eosinofili) mu magufa.

• Ibimenyetso nibimenyetso bya karande ya eosinofilique idakira harimo umuriro no kumva unaniwe cyane.

Indwara ya eosinofilique idakira ni indwara ikoreramo uturemangingo twinshi twamaraso yera (eosinofili) mu magufa.

Eosinofile ni selile yamaraso yera ikora allergène (ibintu bitera igisubizo cya allergique) kandi igafasha kurwanya indwara ziterwa na parasite zimwe. Muri leukemia idakira ya eosinofilique, hariho eosinofile nyinshi mumaraso, igufwa ryamagufa, nizindi ngingo. Indwara ya eosinofilike idakira irashobora kuguma kumyaka myinshi cyangwa irashobora gutera imbere vuba kuri leukemia ikaze.

Ibimenyetso nibimenyetso bya karande ya eosinofilique idakira harimo umuriro no kumva unaniwe cyane.

Indwara ya eosinofilique idakira ntishobora gutera ibimenyetso cyangwa ibimenyetso hakiri kare. Irashobora kuboneka mugihe cyo kwisuzumisha bisanzwe. Ibimenyetso nibimenyetso bishobora guterwa na leukemia idakira ya eosinofilique cyangwa nibindi bihe. Menyesha umuganga wawe niba ufite kimwe muri ibi bikurikira:

• Umuriro.

• Kumva unaniwe cyane.

• Inkorora.

• Kubyimba munsi y'uruhu ruzengurutse amaso n'iminwa, mu muhogo, cyangwa ku biganza no ku birenge.

• Kubabara imitsi.

• Gucura.

• Impiswi.

Icyiciro cya Myeloproliferative Neoplasms idakira

INGINGO Z'INGENZI

• Nta sisitemu isanzwe yo kubika kuri myeloproliferative neoplasms idakira.

Nta sisitemu isanzwe yo kubika kuri myeloproliferative neoplasms idakira.

Gutegura ni inzira ikoreshwa mu kumenya intera kanseri imaze gukwirakwira. Nta sisitemu isanzwe yo kubika kuri myeloproliferative neoplasms idakira. Umuti ushingiye ku bwoko bwa myeloproliferative neoplasm umurwayi afite. Ni ngombwa kumenya ubwoko kugirango utegure kuvura.

Incamake yo kuvura

INGINGO Z'INGENZI

• Hariho uburyo butandukanye bwo kuvura abarwayi bafite myeloproliferative neoplasme idakira.

• Ubwoko 11 bwo kuvura busanzwe bukoreshwa:

• Gutegereza neza

• Phlebotomy

• Platelet apheresis

• Ubuvuzi bwo guterwa

• Chimoterapi

• Imiti ivura imirasire

• Ubundi buryo bwo kuvura ibiyobyabwenge

• Kubaga

• Ubuvuzi bwibinyabuzima

• Ubuvuzi bugamije

• Imiti myinshi ya chimiotherapie hamwe no guterwa ingirabuzimafatizo

• Ubwoko bushya bwo kuvura burimo kugeragezwa mubigeragezo byamavuriro.

• Umuti wa myeloproliferative neoplasme idakira urashobora gutera ingaruka.

• Abarwayi barashobora kwifuza gutekereza kubijyanye no kwipimisha kwa muganga.

• Abarwayi barashobora kwipimisha kwa muganga mbere, mugihe, cyangwa nyuma yo gutangira kuvura kanseri.

• Ibizamini byo gukurikirana birashobora gukenerwa.

Hariho uburyo butandukanye bwo kuvura abarwayi bafite myeloproliferative neoplasme idakira.

Ubwoko butandukanye bwo kuvura burahari kubarwayi bafite myeloproliferative neoplasme idakira. Bumwe mu buryo busanzwe (ubuvuzi bukoreshwa ubu), kandi bumwe burimo kugeragezwa mubigeragezo byamavuriro. Ikigeragezo kivura ni ubushakashatsi bwakozwe bugamije gufasha kunoza imiti igezweho cyangwa kubona amakuru kubuvuzi bushya. Iyo ibizamini byo kwa muganga byerekana ko ubuvuzi bushya buruta ubuvuzi busanzwe, ubuvuzi bushya bushobora kuba ubuvuzi busanzwe. Abarwayi barashobora kwifuza gutekereza kubijyanye no kwipimisha kwa muganga. Ibigeragezo bimwe na bimwe bivura abarwayi batatangiye kwivuza.

Ubwoko 11 bwo kuvura busanzwe bukoreshwa:

Gutegereza neza

Gutegereza witonze ni ugukurikiranira hafi uko umurwayi ameze atabanje kwivuza kugeza ibimenyetso cyangwa ibimenyetso bigaragara cyangwa bihindutse.

Phlebotomy

Phlebotomy ni uburyo bwo gukuramo amaraso mu mitsi. Urugero rwamaraso rushobora gufatwa kugirango bipimishe nka CBC cyangwa chimie yamaraso. Rimwe na rimwe, phlebotomy ikoreshwa nk'ubuvuzi kandi amaraso akurwa mu mubiri kugirango akureho uturemangingo twinshi dutukura. Phlebotomy ikoreshwa murubu buryo bwo kuvura indwara ya myeloproliferative idakira.

Platelet apheresis

Platelet apheresis nubuvuzi bukoresha imashini idasanzwe kugirango ikure platine mumaraso. Amaraso akurwa kumurwayi agashyirwa mubice bitandukanya amaraso aho platine ikurwa. Amaraso asigaye noneho asubizwa mumaraso yumurwayi.

Ubuvuzi bwo guterwa

Ubuvuzi bwa Transfusion (transfusion) nuburyo bwo gutanga uturemangingo twamaraso dutukura, selile yera, cyangwa platine kugirango dusimbure selile yamaraso yangijwe nindwara cyangwa kuvura kanseri.

Chimoterapi

Chimoterapi ni umuti wa kanseri ukoresha ibiyobyabwenge kugirango uhagarike imikurire ya kanseri, haba mu kwica selile cyangwa kubabuza gutandukana. Iyo chimiotherapie ifashwe numunwa cyangwa igaterwa mumitsi cyangwa imitsi, imiti yinjira mumaraso kandi irashobora kugera kanseri ya kanseri mumubiri (chimiotherapie sisitemu). Iyo chimiotherapie ishyizwe mumazi yubwonko, urugingo, cyangwa umwobo wumubiri nkinda, imiti yibasira kanseri ya kanseri muri utwo turere (chimiotherapie yo mukarere). Uburyo chimiotherapie itangwa biterwa nubwoko nicyiciro cya kanseri ivurwa.

Reba Ibiyobyabwenge Byemewe kuri Myeloproliferative Neoplasms kubindi bisobanuro.

Imiti ivura imirasire

Imishwarara ivura ni imiti ikoresha kanseri ikoresha ingufu nyinshi za x-imirasire cyangwa ubundi bwoko bwimirasire yica kanseri cyangwa ikabuza gukura. Imiti ivura hanze ikoresha imashini hanze yumubiri kugirango yohereze imirasire yerekeza kumubiri hamwe na kanseri.

Imiti ivura imishwarara yo hanze ikoreshwa mu kuvura indwara ya myeloproliferative neoplasme idakira, kandi ubusanzwe yerekeza ku ruhago.

Ubundi buryo bwo kuvura ibiyobyabwenge

Prednisone na danazol ni imiti ishobora gukoreshwa mu kuvura amaraso make ku barwayi barwaye myelofibrosis y'ibanze.

Ubuvuzi bwa Anagrelide bukoreshwa mu kugabanya ibyago byo gutembera kw'amaraso ku barwayi bafite platine nyinshi mu maraso yabo. Asipirine ikabije irashobora kandi gukoreshwa kugirango igabanye ibyago byo gutembera kw'amaraso.

Thalidomide, lenalidomide, na pomalidomide ni imiti ibuza imiyoboro y'amaraso gukura mu bice bigize selile.

Reba Ibiyobyabwenge Byemewe kuri Myeloproliferative Neoplasms kubindi bisobanuro.

Kubaga

Splenectomy (kubaga kugirango ikureho intanga) irashobora gukorwa mugihe ururenda rwagutse.

Ubuvuzi bwibinyabuzima

Ubuvuzi bwa biologiya nubuvuzi bukoresha sisitemu yumubiri yumurwayi kurwanya kanseri cyangwa izindi ndwara. Ibintu bikozwe numubiri cyangwa bikozwe muri laboratoire bikoreshwa mukuzamura, kuyobora, cyangwa kugarura umubiri kamere wirinda indwara. Ubu bwoko bwo kuvura nabwo bwitwa biotherapy cyangwa immunotherapy. Interferon alfa na pegylated interferon alpha ni ibinyabuzima bisanzwe bikoreshwa mukuvura neoplasme idakira.

Imikurire ya Erythropoietic nayo ni ibinyabuzima. Zikoreshwa mu gukangura amagufwa yo gukora selile zitukura.

Ubuvuzi bugamije

Ubuvuzi bugamije ni uburyo bwo kuvura bukoresha ibiyobyabwenge cyangwa ibindi bintu kugirango umenye kandi utere kanseri yihariye ya kanseri utangiza ingirabuzimafatizo zisanzwe. Tyrosine kinase inhibitor ni imiti igamije kuvura ibuza ibimenyetso bikenewe kugirango ibibyimba bikure.

Ruxolitinib ni tyrosine kinase inhibitor ikoreshwa mu kuvura polycythemia vera hamwe nubwoko bumwe na bumwe bwa myelofibrosis.

Reba Ibiyobyabwenge Byemewe kuri Myeloproliferative Neoplasms kubindi bisobanuro.

Ubundi bwoko bwubuvuzi bugamije kwigwa mubigeragezo byamavuriro.

Imiti myinshi ya chimiotherapie hamwe no guterwa ingirabuzimafatizo

Umubare munini wa chimiotherapie utangwa kugirango wice selile. Ingirabuzimafatizo nzima, harimo na selile zikora amaraso, nazo zirasenywa no kuvura kanseri. Gutera ingirabuzimafatizo ni uburyo bwo gusimbuza ingirabuzimafatizo. Ingirabuzimafatizo (selile zidakuze) zivanwa mumaraso cyangwa igufwa ryumurwayi cyangwa umuterankunga hanyuma bikonjeshwa bikabikwa. Nyuma yuko umurwayi arangije chimiotherapie, selile stem yabitswe irashonga hanyuma igasubizwa umurwayi binyuze muri infusion. Izi ngirabuzimafatizo zongeye gukoreshwa zikura (kandi zigarura) ingirangingo z'amaraso z'umubiri.

Gutera ingirabuzimafatizo. (Intambwe ya 1): Amaraso yakuwe mumitsi mumaboko yumuterankunga. Umurwayi cyangwa undi muntu ashobora kuba umuterankunga. Amaraso atembera mumashini ikuraho ingirabuzimafatizo. Noneho amaraso asubizwa abaterankunga binyuze mumitsi mumaboko yandi. (Intambwe ya 2): Umurwayi yakira chimiotherapie kugirango yice selile zikora amaraso. Umurwayi arashobora guhabwa imiti ivura imirasire (iterekanwa). (Intambwe ya 3): Umurwayi yakira ingirabuzimafatizo binyuze muri catheter yashyizwe mu maraso mu gituza.

Ubwoko bushya bwo kuvura burimo kugeragezwa mubigeragezo byamavuriro.

Amakuru yerekeye ibizamini byamavuriro araboneka kurubuga rwa NCI.

Umuti wa myeloproliferative neoplasme idakira urashobora gutera ingaruka.

Kumakuru yingaruka ziterwa no kuvura kanseri, reba urupapuro rwuruhande rwacu.

Abarwayi barashobora kwifuza gutekereza kubijyanye no kwipimisha kwa muganga.

Ku barwayi bamwe, kwitabira ikizamini cyamavuriro birashobora kuba uburyo bwiza bwo kuvura. Ibigeragezo bivura biri mubikorwa byubushakashatsi bwa kanseri. Igeragezwa rya Clinical rikorwa kugirango hamenyekane niba imiti mishya ya kanseri itekanye kandi ifite akamaro cyangwa nziza kuruta ubuvuzi busanzwe.

Benshi mubuvuzi busanzwe bwa kanseri bushingiye kubigeragezo byambere byubuvuzi. Abarwayi bitabiriye kwipimisha barashobora kuvurwa bisanzwe cyangwa kuba mubambere bahawe imiti mishya.

Abarwayi bitabira ibizamini byo kwa muganga nabo bafasha kunoza uburyo kanseri izavurwa mugihe kizaza. Nubwo ibigeragezo bivura bitaganisha ku buvuzi bushya, akenshi basubiza ibibazo byingenzi kandi bigafasha gutera imbere ubushakashatsi.

Abarwayi barashobora kwipimisha kwa muganga mbere, mugihe, cyangwa nyuma yo gutangira kuvura kanseri.

Igeragezwa rimwe na rimwe ririmo abarwayi bataravurwa. Ibindi bigeragezo bipima abarwayi bafite kanseri itameze neza. Hariho kandi ibizamini byo kwa muganga bipima uburyo bushya bwo guhagarika kanseri kongera kugaruka (kugaruka) cyangwa kugabanya ingaruka zo kuvura kanseri.

Igeragezwa rya Clinical ririmo kubera mu bice byinshi by'igihugu. Amakuru yerekeye ibizamini byamavuriro ashyigikiwe na NCI urashobora kubisanga kurubuga rwa NCI. Ibizamini bya Clinical bishyigikiwe nandi mashyirahamwe murashobora kubisanga kurubuga rwa ClinicalTrials.gov.

Ibizamini byo gukurikirana birashobora gukenerwa.

Bimwe mubizamini byakozwe mugupima kanseri cyangwa kumenya icyiciro cya kanseri birashobora gusubirwamo. Ibizamini bimwe bizasubirwamo kugirango harebwe uburyo ubuvuzi bukora neza. Ibyemezo bijyanye no gukomeza, guhindura, cyangwa guhagarika ubuvuzi birashobora gushingira kubisubizo byibi bizamini.

Bimwe mubizamini bizakomeza gukorwa buri gihe nyuma yubuvuzi burangiye. Ibisubizo by'ibi bizamini birashobora kwerekana niba ubuzima bwawe bwarahindutse cyangwa niba kanseri yarongeye (garuka). Ibi bizamini rimwe na rimwe byitwa gukurikirana-ibizamini cyangwa kugenzura.

Ubuvuzi bwa Neoplasme idakira

Muri iki gice

• Indwara ya Myelogenous Leukemia

• Polycythemia Vera

• Myelofibrosis

• Ibyingenzi bya Thrombocythemia

• Indwara ya Leutemia idakira

• Indwara ya Eosinofilike idakira

Kumakuru yerekeye imiti yavuzwe hepfo, reba igice cyo kuvura.

Indwara ya Myelogenous Leukemia

Reba incamake ya kubyerekeranye na Chronique Myelogenous Leukemia ivura amakuru.

Polycythemia Vera

Intego yo kuvura polycythemia vera ni ukugabanya umubare wingirabuzimafatizo ziyongera. Kuvura polycythemia vera bishobora kuba bikubiyemo ibi bikurikira:

• Phlebotomy.

• Chimiotherapie hamwe na phlebotomy. Niba chimiotherapie idakora, imiti igamije (ruxolitinib) irashobora gutangwa.

• Ubuvuzi bwibinyabuzima ukoresheje interferon alfa cyangwa pegylated interferon alpha.

• Asipirine ikabije.

Koresha ubushakashatsi bwamavuriro kugirango ushakishe NCI ifashwa na kanseri ivura abarwayi. Urashobora gushakisha ibigeragezo ukurikije ubwoko bwa kanseri, imyaka yumurwayi, n’aho ibizamini bikorerwa. Amakuru rusange yerekeye ibizamini byamavuriro nayo arahari.

Myelofibrosis

Kuvura myelofibrosis yibanze kubarwayi badafite ibimenyetso cyangwa ibimenyetso mubisanzwe bategereje.

Abarwayi bafite myelofibrosis y'ibanze barashobora kugira ibimenyetso cyangwa ibimenyetso byo kubura amaraso. Anemia isanzwe ivurwa no guterwa uturemangingo twamaraso dutukura kugirango igabanye ibimenyetso kandi imibereho myiza. Byongeye kandi, anemia irashobora kuvurwa hamwe na:

• Impamvu zo gukura kwa Erythropoietic.

• Prednisone.

• Danazol.

• Thalidomide, lenalidomide, cyangwa pomalidomide, hamwe na prednisone cyangwa idafite.

Kuvura myelofibrosis yibanze kubarwayi bafite ibindi bimenyetso cyangwa ibimenyetso bishobora kubamo ibi bikurikira:

• Ubuvuzi bugamije hamwe na ruxolitinib.

• Chimoterapi.

• Abaterankunga batewe ingirabuzimafatizo.

• Thalidomide, lenalidomide, cyangwa pomalidomide.

• Gutandukana.

• Imishwarara ivura ururenda, lymph node, cyangwa ahandi hantu hanze yamagufa aho uturemangingo twamaraso tuba.

• Ubuvuzi bwibinyabuzima ukoresheje interferon alfa cyangwa erythropoietic ibintu bikura.

• Igeragezwa rya clinique yindi miti igamije kuvura.

Koresha ubushakashatsi bwamavuriro kugirango ushakishe NCI ifashwa na kanseri ivura abarwayi. Urashobora gushakisha ibigeragezo ukurikije ubwoko bwa kanseri, imyaka yumurwayi, n’aho ibizamini bikorerwa. Amakuru rusange yerekeye ibizamini byamavuriro nayo arahari.

Ibyingenzi bya Thrombocythemia

Kuvura trombocythemia yingenzi kubarwayi barengeje imyaka 60 badafite ibimenyetso cyangwa ibimenyetso kandi numubare wa platine wemewe mubisanzwe utegereje. Kuvura abandi barwayi bishobora kubamo ibi bikurikira:

• Chimoterapi.

• Ubuvuzi bwa Anagrelide.

• Ubuvuzi bwibinyabuzima ukoresheje interferon alfa cyangwa pegylated interferon alpha.

• Amashanyarazi.

• Ikigeragezo cyamavuriro yubuvuzi bushya.

Koresha ubushakashatsi bwamavuriro kugirango ushakishe NCI ifashwa na kanseri ivura abarwayi. Urashobora gushakisha ibigeragezo ukurikije ubwoko bwa kanseri, imyaka yumurwayi, n’aho ibizamini bikorerwa. Amakuru rusange yerekeye ibizamini byamavuriro nayo arahari.

Indwara ya Leutemia idakira

Kuvura indwara ya leutemiya idakira irashobora kuba ikubiyemo ibi bikurikira:

• Abaterankunga batewe amagufa.

• Chimoterapi.

• Ubuvuzi bwibinyabuzima ukoresheje interferon alfa.

• Ikigeragezo cyamavuriro yubuvuzi bushya.

Koresha ubushakashatsi bwamavuriro kugirango ushakishe NCI ifashwa na kanseri ivura abarwayi. Urashobora gushakisha ibigeragezo ukurikije ubwoko bwa kanseri, imyaka yumurwayi, n’aho ibizamini bikorerwa. Amakuru rusange yerekeye ibizamini byamavuriro nayo arahari.

Indwara ya Eosinofilike idakira

Kuvura leukemia idakira irashobora kuba ikubiyemo ibi bikurikira:

• Guhindura amagufwa.

• Ubuvuzi bwibinyabuzima ukoresheje interferon alfa.

• Ikigeragezo cyamavuriro yubuvuzi bushya.

Koresha ubushakashatsi bwamavuriro kugirango ushakishe NCI ifashwa na kanseri ivura abarwayi. Urashobora gushakisha ibigeragezo ukurikije ubwoko bwa kanseri, imyaka yumurwayi, n’aho ibizamini bikorerwa. Amakuru rusange yerekeye ibizamini byamavuriro nayo arahari.

Kugira ngo umenye byinshi kuri Neoplasme ya Myeloproliferative idakira

Ushaka amakuru menshi yikigo cyigihugu cya kanseri kubyerekeye neoplasme idakira, reba ibi bikurikira:

• Myeloproliferative Neoplasms Urupapuro rwurugo

• Ibiyobyabwenge Byemewe kuri Myeloproliferative Neoplasms

• Immunotherapy yo kuvura Kanseri

• Gutera Amaraso Yimitsi Yimitsi

• Intego zo kuvura Kanseri

Kumakuru rusange ya kanseri nibindi bikoresho biva mu kigo cyigihugu cya kanseri, reba ibi bikurikira:

• Ibyerekeye Kanseri

• Gutegura

• Chimiotherapie nawe: Inkunga kubantu barwaye Kanseri

• Ubuvuzi bwimirasire nawe: Inkunga kubantu barwaye Kanseri

• Guhangana na Kanseri

• Ibibazo byo Kubaza Muganga wawe kuri Kanseri

• Abacitse ku icumu n'abarezi