Ubwoko / lymphoma / umurwayi / mycose-fungoides-kuvura-pdq

Mycose Fungoides (Harimo na Sézary Syndrome) Umuti (®) –Icyiciro cy'abarwayi

Amakuru Rusange Yerekeye Mycose Fungoides (Harimo Syndrome ya Sézary)

INGINGO Z'INGENZI

• Indwara ya Mycose fungoide na syndrome ya Sézary ni indwara aho lymphocytes (ubwoko bw'uturemangingo tw'amaraso yera) ziba mbi (kanseri) zikagira ingaruka ku ruhu.

• Mycose fungoides na syndrome ya Sézary ni ubwoko bwa lymphoma ya T-selile.

• Ikimenyetso cya mycose fungoides nigituba gitukura kuruhu.

• Muri syndrome ya Sézary, T-selile ya kanseri iboneka mu maraso.

• Ibizamini bisuzuma uruhu n'amaraso bikoreshwa mugupima mycose fungoide na syndrome ya Sézary.

• Ibintu bimwe bigira ingaruka kubitekerezo (amahirwe yo gukira) hamwe nuburyo bwo kuvura.

Indwara ya Mycose fungoide na syndrome ya Sézary ni indwara aho lymphocytes (ubwoko bw'uturemangingo tw'amaraso yera) ziba mbi (kanseri) zikagira ingaruka ku ruhu.

Mubisanzwe, igufwa ryamagufa rituma ingirangingo zamaraso (selile zidakuze) zihinduka ingirabuzimafatizo zamaraso zikuze mugihe runaka. Ingirabuzimafatizo y'amaraso irashobora guhinduka myeloid stem selile cyangwa lymphoide stem selile. Ingirabuzimafatizo ya myeloid ihinduka selile itukura, selile yera, cyangwa platine. Lymphoide stem selile ihinduka lymphoblast hanyuma noneho bumwe mubwoko butatu bwa lymphocytes (selile yera):

• Lymphocytes B-selile ikora antibodies zifasha kurwanya kwandura.

• T-selile lymphocytes ifasha B-lymphocytes gukora antibodies zifasha kurwanya kwandura.

• Ingirabuzimafatizo zica zitera kanseri na virusi.

Gukura kw'amaraso. Ingirabuzimafatizo y'amaraso inyura mu ntambwe nyinshi kugirango ihinduke selile itukura, platine, cyangwa selile yera.

Muri mycose fungoide, Lymphocytes T-selile iba kanseri kandi igira ingaruka kuruhu. Iyo izo lymphocytes zibaye mumaraso, zitwa selile Sézary. Muri syndrome ya Sézary, kanseri ya T-selile lymphocytes igira ingaruka ku ruhu kandi umubare munini wa selile Sézary uboneka mu maraso.

Mycose fungoides na syndrome ya Sézary ni ubwoko bwa lymphoma ya T-selile.

Mycose fungoide na syndrome ya Sézary nubwoko bubiri bukunze kugaragara bwa lymphoma ya T-selile (ubwoko bwa lymphoma itari Hodgkin). Kumakuru yerekeye ubundi bwoko bwa kanseri y'uruhu cyangwa lymphoma itari Hodgkin, reba incamake ya ikurikira:

• Abakuze Kuvura Lymphoma Ntabwo Hodgkin

• Kuvura Kanseri y'uruhu

• Umuti wa Melanoma

• Umuti wa Kaposi Sarcoma

Ikimenyetso cya mycose fungoides nigituba gitukura kuruhu.

Mycose fungoide irashobora kunyura mubice bikurikira:

• Icyiciro cya premycotic: Igicucu, gitukura mu bice byumubiri ubusanzwe bitagaragara ku zuba. Uku guhubuka ntigutera ibimenyetso kandi birashobora kumara amezi cyangwa imyaka. Biragoye gusuzuma ibisebe nka mycose fungoide muriki cyiciro.

• Icyiciro cya patch: Gito, gitukura, eczema-isa nigisebe.

• Icyiciro cya plaque: Uduce duto twazamuye (papules) cyangwa ibikomere bikomereye kuruhu, bishobora gutukura.

• Icyiciro cya Tumor: Ibibyimba bibaho kuruhu. Ibi bibyimba birashobora gutera ibisebe kandi uruhu rushobora kwandura.

Menyesha muganga wawe niba ufite kimwe muri ibyo bimenyetso.

Muri syndrome ya Sézary, T-selile ya kanseri iboneka mu maraso.

Nanone, uruhu umubiri wose rutukura, kuribwa, gukuramo, no kubabaza. Hashobora kandi kuba ibibyimba, icyapa, cyangwa ibibyimba kuruhu. Ntabwo bizwi niba syndrome ya Sézary ari uburyo bwateye imbere bwa mycose fungoide cyangwa indwara itandukanye.

Ibizamini bisuzuma uruhu n'amaraso bikoreshwa mugupima mycose fungoide na syndrome ya Sézary.

Ibizamini hamwe nuburyo bukurikira birashobora gukoreshwa:

• Ikizamini cyumubiri namateka yubuzima: Ikizamini cyumubiri kugirango ugenzure ibimenyetso rusange byubuzima, harimo no gusuzuma ibimenyetso byindwara, nkibibyimba, umubare nubwoko bwibisebe byuruhu, cyangwa ikindi kintu cyose gisa nkidasanzwe. Amashusho y'uruhu n'amateka yubuzima bwumurwayi * ingeso nindwara zashize hamwe nubuvuzi nabyo bizafatwa.

• Umubare wuzuye wamaraso ufite itandukaniro: Uburyo bwo gukuramo urugero rwamaraso no kugenzurwa kuri ibi bikurikira:

• Umubare w'uturemangingo tw'amaraso atukura na platine.

• Umubare nubwoko bwingirangingo zamaraso yera.

• Ingano ya hemoglobine (proteyine itwara ogisijeni) mu ngirangingo z'amaraso atukura.

• Igice cyicyitegererezo cyamaraso kigizwe ningirabuzimafatizo zitukura.

Kubara amaraso yuzuye (CBC). Amaraso akusanywa no kwinjiza inshinge mumitsi no kwemerera amaraso gutembera mumiyoboro. Icyitegererezo cyamaraso cyoherezwa muri laboratoire hanyuma selile zitukura, selile yera, na platine zirabaze. CBC ikoreshwa mugupima, gusuzuma, no gukurikirana ibintu byinshi bitandukanye.

• Umubare w'amaraso ya Sézary: Uburyo bwo kureba urugero rw'amaraso munsi ya microscope kugirango ubare umubare w'utugingo ngengabuzima twa Sézary.

• Kwipimisha virusi itera sida: Ikizamini cyo gupima urugero rwa antibodi ya virusi itera sida. Antibodies zikorwa numubiri iyo zatewe nibintu byamahanga. Urwego rwo hejuru rwa antibodiyite ya sida rushobora gusobanura ko umubiri wanduye virusi itera sida.

• Uruhu biopsy: Gukuraho ingirabuzimafatizo cyangwa ingirangingo kugirango zishobore kurebwa munsi ya microscope kugirango barebe ibimenyetso bya kanseri. Muganga arashobora gukuraho imikurire y'uruhu, izasuzumwa na patologue. Biopsy irenze imwe y'uruhu irashobora gukenerwa kugirango tumenye mycose fungoide. Ibindi bizamini bishobora gukorwa kuri selile cyangwa sample tissue harimo ibi bikurikira:

• Immunophenotyping: Ikizamini cya laboratoire ikoresha antibodies kugirango hamenyekane kanseri ya kanseri ukurikije ubwoko bwa antigene cyangwa ibimenyetso hejuru ya selile. Iki kizamini gikoreshwa mugufasha gusuzuma ubwoko bwihariye bwa lymphoma.

• Flow cytometry: Ikizamini cya laboratoire gipima umubare w'utugingo ngengabuzima, ijanisha ry'utugingo ngengabuzima turi mu cyitegererezo, hamwe n'ibiranga ingirabuzimafatizo, nk'ubunini, imiterere, hamwe n'ibimenyetso by'ibibyimba (cyangwa ibindi) kuri Ubuso. Ingirabuzimafatizo ziva mu cyitegererezo cy'amaraso y'umurwayi, igufwa ry'amagufa, cyangwa izindi ngingo zandujwe irangi rya fluorescent, zishyirwa mu mazi, hanyuma zikanyura rimwe na rimwe binyuze mu rumuri. Ibisubizo by'ibizamini bishingiye ku kuntu ingirabuzimafatizo zandujwe irangi rya fluorescent zifata urumuri. Iki kizamini gikoreshwa mugufasha gusuzuma no gucunga ubwoko bumwe na bumwe bwa kanseri, nka leukemia na lymphoma.

• Ikizamini cya T-selile (TCR) ikizamini cyo kuvugurura gene: Ikizamini cya laboratoire aho hasuzumwa ingirabuzimafatizo z'amaraso cyangwa igufwa ry'amagufwa kugira ngo harebwe niba hari impinduka zimwe na zimwe zigira ingirabuzimafatizo zikora reseptor kuri selile T (selile yera). Kwipimisha kuri izi mpinduka za gene birashobora kumenya niba hakorwa umubare munini wa selile T hamwe na reseptor ya T-selile runaka.

Ibintu bimwe bigira ingaruka kubitekerezo (amahirwe yo gukira) hamwe nuburyo bwo kuvura.

Amahitamo yo kuvura no kuvura biterwa nibi bikurikira:

• Intambwe ya kanseri.

• Ubwoko bw'igisebe (ibibyimba, icyapa, cyangwa ibibyimba).

• Imyaka yumurwayi nuburinganire.

Mycose fungoides na syndrome ya Sézary biragoye gukira. Ubuvuzi busanzwe butera, kugabanya ibimenyetso no kuzamura imibereho. Abarwayi bafite uburwayi bwambere barashobora kubaho imyaka myinshi.

Icyiciro cya Mycose Fungoides (Harimo Syndrome ya Sézary)

INGINGO Z'INGENZI

• Nyuma yo gupimwa na mycose fungoide na syndrome ya Sézary, hakorwa ibizamini kugirango hamenyekane niba kanseri ya kanseri yakwirakwiriye mu ruhu ikagera mu bindi bice by'umubiri.

• Hariho uburyo butatu kanseri ikwirakwira mu mubiri.

• Kanseri irashobora gukwirakwira aho yatangiriye no mu bindi bice byumubiri.

• Ibyiciro bikurikira bikoreshwa kuri mycose fungoides na syndrome ya Sézary:

• Icyiciro cya I Mycose Fungoides

• Icyiciro cya II Mycose Fungoides

• Icyiciro cya III Mycose Fungoides

• Icyiciro cya IV Mycose Fungoides / Indwara ya Sézary

Nyuma yo gupimwa na mycose fungoide na syndrome ya Sézary, hakorwa ibizamini kugirango hamenyekane niba kanseri ya kanseri yakwirakwiriye mu ruhu ikagera mu bindi bice by'umubiri.

Inzira ikoreshwa mu kumenya niba kanseri yarakwirakwiriye kuva mu ruhu kugera mu bindi bice byumubiri byitwa guterana. Amakuru yakusanyirijwe mubikorwa byateguwe agena icyiciro cyindwara. Ni ngombwa kumenya icyiciro kugirango utegure kuvura.

Uburyo bukurikira burashobora gukoreshwa mugutegura:

• Isanduku x-ray: X-ray yingingo namagufwa imbere yigituza. X-ray ni ubwoko bwingufu zishobora kunyura mumubiri no kuri firime, bigakora ishusho yibice byumubiri.

• CT scan (CAT scan): Uburyo bukora urukurikirane rwamashusho arambuye yibice byimbere mumubiri, nka lymph node, igituza, inda, na pelvis, byafashwe muburyo butandukanye. Amashusho yakozwe na mudasobwa ihujwe na mashini ya x-ray. Irangi rishobora guterwa mumitsi cyangwa kumirwa kugirango bifashe ingingo cyangwa ingirangingo kugaragara neza. Ubu buryo nabwo bwitwa computing tomografiya, tomografiya ya mudasobwa, cyangwa mudasobwa ya axial tomografiya.

• PET scan (positron emission tomografi scan): Uburyo bwo kubona selile mbi yibibyimba mumubiri. Umubare muto wa glucose ikora radio (isukari) yatewe mumitsi. PET scaneri izenguruka umubiri kandi ikora ishusho yerekana aho glucose ikoreshwa mumubiri. Utugingo ngengabuzima twibibyimba twerekana neza cyane ku ishusho kuko zikora cyane kandi zifata glucose nyinshi kuruta selile zisanzwe.

• Lymph node biopsy: Gukuraho ibintu byose cyangwa igice cya lymph node. Inzobere mu bijyanye n’indwara ireba lymph node tissue munsi ya microscope kugirango isuzume selile.

• Amagufa ya marrow aspiration na biopsy: Gukuraho igufwa ryamagufwa nigice gito cyamagufwa winjiza urushinge rufunitse mumatako cyangwa amabere. Inzobere mu by'indwara ireba igufwa n'amagufwa munsi ya microscope kugira ngo ishakishe ibimenyetso bya kanseri.

Hariho uburyo butatu kanseri ikwirakwira mu mubiri.

Kanseri irashobora gukwirakwira binyuze mu ngingo, sisitemu ya lymph, n'amaraso:

• Tissue. Kanseri ikwirakwira aho yatangiriye ikurira mu turere twegereye.

• Sisitemu ya Lymph. Kanseri ikwirakwira aho yatangiriye yinjira muri sisitemu ya lymph. Kanseri inyura mu mitsi ya lymph igana mu bindi bice by'umubiri.

• Amaraso. Kanseri ikwirakwira aho yatangiriye yinjira mu maraso. Kanseri inyura mu mitsi y'amaraso igana mu bindi bice by'umubiri.

Kanseri irashobora gukwirakwira aho yatangiriye no mu bindi bice byumubiri.

Iyo kanseri ikwirakwira mu kindi gice cy'umubiri, yitwa metastasis. Ingirabuzimafatizo za kanseri zitandukana aho zatangiriye (ikibyimba kibanza) zikanyura muri sisitemu ya lymph cyangwa maraso.

Sisitemu ya Lymph. Kanseri yinjira muri sisitemu ya lymph, ikanyura mu mitsi ya lymph, igakora ikibyimba (ikibyimba metastatike) mu kindi gice cy'umubiri.

Amaraso. Kanseri yinjira mu maraso, ikanyura mu mitsi y'amaraso, igakora ikibyimba (ikibyimba metastatike) mu kindi gice cy'umubiri. Ikibyimba metastatike nubwoko bumwe bwa kanseri nkibibyimba byibanze. Kurugero, niba mycose fungoide ikwirakwira mu mwijima, kanseri ya kanseri mu mwijima ni selile mycose fungoides. Indwara ni metastatike mycose fungoide, ntabwo ari kanseri y'umwijima.

Ibyiciro bikurikira bikoreshwa kuri mycose fungoides na syndrome ya Sézary:

Icyiciro cya I Mycose Fungoides

Icyiciro cya I kigabanijwe mu byiciro IA na IB ku buryo bukurikira:

• Icyiciro cya IA: Ibishishwa, papula, na / cyangwa ibyapa bitwikiriye munsi ya 10% yubuso bwuruhu.

• Icyiciro cya IB: Ibishishwa, papula, na / cyangwa ibyapa bitwikiriye 10% cyangwa byinshi hejuru yuruhu.

• Hashobora kuba umubare muke wa selile Sézary mumaraso.

Icyiciro cya II Mycose Fungoides

Icyiciro cya II kigabanijwe mu byiciro IIA na IIB ku buryo bukurikira:

• Icyiciro cya IIA: Ibishishwa, papula, na / cyangwa ibyapa bitwikiriye ubunini bwuruhu. Indimu ya Lymph ntisanzwe, ariko ntabwo ari kanseri.

• Icyiciro cya IIB: Ikibyimba kimwe cyangwa byinshi bifite santimetero 1 cyangwa binini biboneka kuruhu. Indimu ya Lymph irashobora kuba idasanzwe, ariko ntabwo ari kanseri.

Hashobora kuba umubare muke wa selile Sézary mumaraso.

Icyiciro cya III Mycose Fungoides

Mu cyiciro cya III, 80% cyangwa birenga hejuru yuruhu rutukura kandi birashobora kugira ibibyimba, papula, plaque, cyangwa ibibyimba. Indimu ya Lymph irashobora kuba idasanzwe, ariko ntabwo ari kanseri.

Hashobora kuba umubare muke wa selile Sézary mumaraso.

Icyiciro cya IV Mycose Fungoides / Indwara ya Sézary

Iyo mu maraso hari umubare munini wa selile ya Sézary, indwara yitwa syndrome ya Sézary.

Icyiciro cya IV kigabanyijemo ibyiciro IVA1, IVA2, na IVB ku buryo bukurikira:

• Icyiciro cya IVA1: Ibishishwa, papula, plaque, cyangwa ibibyimba birashobora gutwikira urugero urwo arirwo rwose rwuruhu, kandi 80% cyangwa birenga hejuru yuruhu birashobora gutukura. Indimu ya lymph irashobora kuba idasanzwe, ariko ntabwo ari kanseri. Hariho umubare munini w'uturemangingo twa Sézary mumaraso.

• Icyiciro cya IVA2: Ibibyimba, papula, plaque, cyangwa ibibyimba birashobora gutwikira urugero urwo arirwo rwose rwuruhu, kandi 80% cyangwa byinshi hejuru yuruhu birashobora gutukura. Indimu ya lymph ntisanzwe cyane, cyangwa kanseri yabayeho mumitsi. Hashobora kuba umubare munini wingirabuzimafatizo za Sézary mumaraso.

• Icyiciro cya IVB: Kanseri yakwirakwiriye mu zindi ngingo z'umubiri, nk'umugongo cyangwa umwijima. Ibibyimba, papula, plaque, cyangwa ibibyimba birashobora gupfukirana ubunini bwuruhu, kandi 80% cyangwa birenga hejuru yuruhu birashobora gutukura. Indimu ya lymph irashobora kuba idasanzwe cyangwa kanseri. Hashobora kuba umubare munini wingirabuzimafatizo za Sézary mumaraso.

Incamake yo kuvura

INGINGO Z'INGENZI

• Hariho uburyo butandukanye bwo kuvura abarwayi barwaye mycose fungoide na kanseri ya syndrome ya Sézary.

• Ubwoko burindwi bwo kuvura busanzwe bukoreshwa:

• Ubuvuzi bwa Photodynamic

• Imiti ivura imirasire

• Chimoterapi

• Ubundi buryo bwo kuvura ibiyobyabwenge

• Immunotherapy

• Ubuvuzi bugamije

• Imiti myinshi ya chimiotherapie hamwe nubuvuzi bwimirasire hamwe no guhinduranya ingirangingo

• Ubwoko bushya bwo kuvura burimo kugeragezwa mubigeragezo byamavuriro.

• Umuti wa mycose fungoide na syndrome ya Sézary urashobora gutera ingaruka mbi.

• Abarwayi barashobora kwifuza gutekereza kubijyanye no kwipimisha kwa muganga.

• Abarwayi barashobora kwipimisha kwa muganga mbere, mugihe, cyangwa nyuma yo gutangira kuvura kanseri.

• Ibizamini byo gukurikirana birashobora gukenerwa.

Hariho uburyo butandukanye bwo kuvura abarwayi barwaye mycose fungoide na kanseri ya syndrome ya Sézary.

Ubwoko butandukanye bwo kuvura burahari kubarwayi barwaye mycose fungoide na syndrome ya Sézary. Bumwe mu buryo busanzwe (ubuvuzi bukoreshwa ubu), kandi bumwe burimo kugeragezwa mubigeragezo byamavuriro. Ikigeragezo kivura ni ubushakashatsi bwakozwe bugamije gufasha kunoza imiti igezweho cyangwa kubona amakuru ku buvuzi bushya ku barwayi ba kanseri. Iyo ibizamini byo kwa muganga byerekana ko ubuvuzi bushya buruta ubuvuzi busanzwe, ubuvuzi bushya bushobora kuba ubuvuzi busanzwe. Abarwayi barashobora kwifuza gutekereza kubijyanye no kwipimisha kwa muganga. Ibigeragezo bimwe na bimwe bivura abarwayi batatangiye kwivuza.

Ubwoko burindwi bwo kuvura busanzwe bukoreshwa:

Ubuvuzi bwa Photodynamic

Ubuvuzi bwa Photodynamic nubuvuzi bwa kanseri bukoresha ibiyobyabwenge nubwoko runaka bwurumuri rwa laser kugirango bice selile. Umuti udakora kugeza uhuye numucyo utera mumitsi. Umuti ukusanya byinshi muri selile ya kanseri kuruta muri selile zisanzwe. Kuri kanseri y'uruhu, urumuri rwa laser rumurikirwa kuruhu kandi imiti igakora kandi ikica kanseri. Ubuvuzi bwa Photodynamic butera kwangirika kwinyama nzima. Abarwayi barimo kuvura Photodynamic bazakenera kugabanya igihe bamara kumurasire y'izuba. Hariho ubwoko butandukanye bwo kuvura Photodynamic:

• Mu buvuzi bwa psoralen na ultraviolet A (PUVA), umurwayi yakira imiti yitwa psoralen hanyuma ultraviolet Imirasire yerekeza kuruhu.

• Muri fotokoterapi ya extraacorporeal, umurwayi ahabwa ibiyobyabwenge hanyuma selile zimwe zamaraso zikurwa mumubiri, zigashyirwa munsi yumucyo udasanzwe ultraviolet A, hanyuma igasubira mumubiri. Extracorporeal Photochemotherapy irashobora gukoreshwa wenyine cyangwa igahuzwa hamwe nubuvuzi bwuruhu rwa elegitoronike (TSEB).

Imiti ivura imirasire

Imishwarara ivura ni imiti ikoresha kanseri ikoresha ingufu nyinshi za x-imirasire cyangwa ubundi bwoko bwimirasire yica kanseri cyangwa ikabuza gukura. Imiti ivura hanze ikoresha imashini hanze yumubiri kugirango yohereze imirasire yerekeza kumubiri hamwe na kanseri. Rimwe na rimwe, kuvura imirasire ya elegitoronike yuzuye (TSEB) ivura imishwarara ikoreshwa mu kuvura mycose fungoide na syndrome ya Sézary. Ubu ni ubwoko bwo kuvura imishwarara yo hanze aho imashini ivura imirasire igamije electron (utuntu duto, utagaragara) ku ruhu rutwikira umubiri wose. Ubuvuzi bwo hanze bushobora kandi gukoreshwa nkubuvuzi bwa palliative kugirango bugabanye ibimenyetso kandi bizamura imibereho.

Ultraviolet A (UVA) ivura imirasire cyangwa ultraviolet B (UVB) ivura imirasire irashobora gutangwa ukoresheje itara ryihariye cyangwa lazeri iyobora imirasire kuruhu.

Chimoterapi

Chimoterapi ni umuti wa kanseri ukoresha ibiyobyabwenge kugirango uhagarike imikurire ya kanseri, haba mu kwica selile cyangwa kubabuza gutandukana. Iyo chimiotherapie ifashwe numunwa cyangwa igaterwa mumitsi cyangwa imitsi, imiti yinjira mumaraso kandi irashobora kugera kanseri ya kanseri mumubiri (chimiotherapie sisitemu). Rimwe na rimwe, chimiotherapie ni ingenzi (shyira uruhu muri cream, amavuta yo kwisiga, cyangwa amavuta).

Reba Ibiyobyabwenge Byemewe kuri Lymphoma itari Hodgkin kubindi bisobanuro. (Mycose fungoides na syndrome ya Sézary ni ubwoko bwa lymphoma itari Hodgkin.)

Ubundi buryo bwo kuvura ibiyobyabwenge

Corticosteroide yibanze ikoreshwa mugukuraho uruhu rutukura, rwabyimbye, kandi rwaka. Nubwoko bwa steroid. Corticosteroide yibanze irashobora kuba muri cream, amavuta yo kwisiga, cyangwa amavuta.

Retinoide, nka bexarotene, ni imiti ijyanye na vitamine A ishobora gutinda gukura kw'ubwoko bumwe na bumwe bwa kanseri. Retinoide irashobora gufatwa kumunwa cyangwa igashyirwa kuruhu.

Lenalidomide numuti ufasha sisitemu yumubiri kwica selile zidasanzwe zamaraso cyangwa kanseri ya kanseri kandi birashobora gukumira imikurire yimitsi mishya mishya ikibyimba gikeneye gukura.

Vorinostat na romidepsin ni bibiri mu bikoresho bya gistone deacetylase (HDAC) bikoreshwa mu kuvura mycose fungoide na syndrome ya Sézary. Inhibitori ya HDAC itera impinduka yimiti ihagarika selile yibibyimba kugabana.

Reba Ibiyobyabwenge Byemewe kuri Lymphoma itari Hodgkin kubindi bisobanuro. (Mycose fungoides na syndrome ya Sézary ni ubwoko bwa lymphoma itari Hodgkin.)

Immunotherapy

Immunotherapy nubuvuzi bukoresha sisitemu yumubiri yumurwayi kurwanya kanseri. Ibintu bikozwe numubiri cyangwa bikozwe muri laboratoire bikoreshwa mukuzamura, kuyobora, cyangwa kugarura umubiri kamere irinda kanseri. Ubu bwoko bwo kuvura kanseri nabwo bwitwa biotherapy cyangwa biologique therapy.

• Interferon: Ubu buvuzi bubangamira igabana rya mycose fungoide na selile Sézary kandi birashobora kudindiza imikurire.

Reba Ibiyobyabwenge Byemewe kuri Lymphoma itari Hodgkin kubindi bisobanuro. (Mycose fungoides na syndrome ya Sézary ni ubwoko bwa lymphoma itari Hodgkin.)

Ubuvuzi bugamije

Ubuvuzi bugamije ni uburyo bwo kuvura bukoresha ibiyobyabwenge cyangwa ibindi bintu byibasira kanseri. Ubuvuzi bugamije ubusanzwe butera kwangirika kwingirabuzimafatizo zisanzwe kuruta chimiotherapie cyangwa imiti ivura imirasire.

• Ubuvuzi bwa antibody ya Monoclonal: Ubu buvuzi bukoresha antibodies zakozwe muri laboratoire ziva mubwoko bumwe bwimikorere yumubiri. Iyi antibodies irashobora kumenya ibintu biri muri kanseri ya kanseri cyangwa ibintu bisanzwe bishobora gufasha kanseri gukura. Antibodiyite ifata ibintu kandi ikica selile ya kanseri, ikabuza gukura kwayo, cyangwa ikabuza gukwirakwira. Bashobora gukoreshwa bonyine cyangwa gutwara ibiyobyabwenge, uburozi, cyangwa ibikoresho bya radio bikoresha kanseri ya kanseri. Antibodiyite za Monoclonal zitangwa no gushiramo.

Ubwoko bwa antibodiyite za monoclonal zirimo:

• Brentuximab vedotin, irimo antibody ya monoclonal ihuza poroteyine, yitwa CD30, iboneka ku bwoko bumwe na bumwe bwa selile lymphoma. Harimo kandi imiti igabanya ubukana ishobora gufasha kwica kanseri.

• Mogamulizumab, irimo antibody ya monoclonal ihuza poroteyine, yitwa CCR4, iboneka ku bwoko bumwe na bumwe bwa selile lymphoma. Irashobora guhagarika iyi poroteyine kandi igafasha sisitemu yumubiri kwica kanseri. Ikoreshwa mukuvura mycose fungoide na syndrome ya Sézary yagarutse cyangwa itameze neza nyuma yo kuvurwa byibuze hamwe nubuvuzi bumwe.

Imiti myinshi ya chimiotherapie hamwe nubuvuzi bwimirasire hamwe no guhinduranya ingirangingo

Umubare munini wa chimiotherapie kandi rimwe na rimwe imiti ivura imirasire itangwa kugirango yice selile. Ingirabuzimafatizo nzima, harimo na selile zikora amaraso, nazo zirasenywa no kuvura kanseri. Gutera ingirabuzimafatizo ni uburyo bwo gusimbuza ingirabuzimafatizo. Ingirabuzimafatizo (selile zidakuze) zivanwa mumaraso cyangwa igufwa ryumurwayi cyangwa umuterankunga hanyuma bikonjeshwa bikabikwa. Umurwayi amaze kurangiza imiti ya chimiotherapie hamwe nimirasire yimirasire, ingirabuzimafatizo zabitswe zashwanyagujwe hanyuma zisubizwa umurwayi binyuze mu gushiramo. Izi ngirabuzimafatizo zongeye gukoreshwa zikura (kandi zigarura) ingirangingo z'amaraso z'umubiri.

Ubwoko bushya bwo kuvura burimo kugeragezwa mubigeragezo byamavuriro.

Amakuru yerekeye ibizamini byamavuriro araboneka kurubuga rwa NCI.

Umuti wa mycose fungoide na syndrome ya Sézary urashobora gutera ingaruka mbi.

Kumakuru yingaruka ziterwa no kuvura kanseri, reba urupapuro rwuruhande rwacu.

Abarwayi barashobora kwifuza gutekereza kubijyanye no kwipimisha kwa muganga.

Ku barwayi bamwe, kwitabira ikizamini cyamavuriro birashobora kuba uburyo bwiza bwo kuvura. Ibigeragezo bivura biri mubikorwa byubushakashatsi bwa kanseri. Igeragezwa rya Clinical rikorwa kugirango hamenyekane niba imiti mishya ya kanseri itekanye kandi ifite akamaro cyangwa nziza kuruta ubuvuzi busanzwe.

Benshi mubuvuzi busanzwe bwa kanseri bushingiye kubigeragezo byambere byubuvuzi. Abarwayi bitabiriye kwipimisha barashobora kuvurwa bisanzwe cyangwa kuba mubambere bahawe imiti mishya.

Abarwayi bitabira ibizamini byo kwa muganga nabo bafasha kunoza uburyo kanseri izavurwa mugihe kizaza. Nubwo ibigeragezo bivura bitaganisha ku buvuzi bushya, akenshi basubiza ibibazo byingenzi kandi bigafasha gutera imbere ubushakashatsi.

Abarwayi barashobora kwipimisha kwa muganga mbere, mugihe, cyangwa nyuma yo gutangira kuvura kanseri.

Igeragezwa rimwe na rimwe ririmo abarwayi bataravurwa. Ibindi bigeragezo bipima abarwayi bafite kanseri itameze neza. Hariho kandi ibizamini byo kwa muganga bipima uburyo bushya bwo guhagarika kanseri kongera kugaruka (kugaruka) cyangwa kugabanya ingaruka zo kuvura kanseri.

Igeragezwa rya Clinical ririmo kubera mu bice byinshi by'igihugu. Amakuru yerekeye ibizamini byamavuriro ashyigikiwe na NCI urashobora kubisanga kurubuga rwa NCI. Ibizamini bya Clinical bishyigikiwe nandi mashyirahamwe murashobora kubisanga kurubuga rwa ClinicalTrials.gov.

Ibizamini byo gukurikirana birashobora gukenerwa.

Bimwe mubizamini byakozwe mugupima kanseri cyangwa kumenya icyiciro cya kanseri birashobora gusubirwamo. Ibizamini bimwe bizasubirwamo kugirango harebwe uburyo ubuvuzi bukora neza. Ibyemezo bijyanye no gukomeza, guhindura, cyangwa guhagarika ubuvuzi birashobora gushingira kubisubizo byibi bizamini.

Bimwe mubizamini bizakomeza gukorwa buri gihe nyuma yubuvuzi burangiye. Ibisubizo by'ibi bizamini birashobora kwerekana niba ubuzima bwawe bwarahindutse cyangwa niba kanseri yarongeye (garuka). Ibi bizamini rimwe na rimwe byitwa gukurikirana-ibizamini cyangwa kugenzura.

Kuvura Icyiciro cya I na Icyiciro cya II Mycose Fungoides

Kumakuru yerekeye imiti yavuzwe hepfo, reba igice cyo kuvura.

Umuti wo kuvura icyiciro cya mbere nicyiciro cya II mycose fungoide irashobora kuba ikubiyemo ibi bikurikira:

• Psoralen na ultraviolet A (PUVA) ivura imirasire.

• Ultraviolet B ivura imirasire.

• Imishwarara yimishwarara hamwe nubuvuzi bwuzuye uruhu rwa electron. Rimwe na rimwe, imiti ivura imirasire ihabwa ibikomere byuruhu, nkubuvuzi bwa palliative kugirango bugabanye ubunini bwibibyimba kugirango bigabanye ibimenyetso kandi bizamura imibereho.

• Immunotherapy yatanzwe wenyine cyangwa ihujwe nubuvuzi bwerekejwe kuruhu.

• Ubuvuzi bwa chimiotherapie.

• Sisitemu ya chimiotherapie hamwe numuti umwe cyangwa nyinshi, zishobora guhuzwa nubuvuzi bwerekejwe kuruhu.

• Ubundi buryo bwo kuvura imiti (corticosteroide yibanze, kuvura retinoide, lenalidomide, inhibitori ya histone deacetylase).

• Ubuvuzi bugamije (brentuximab vedotin).

Koresha ubushakashatsi bwamavuriro kugirango ushakishe NCI ifashwa na kanseri ivura abarwayi. Urashobora gushakisha ibigeragezo ukurikije ubwoko bwa kanseri, imyaka yumurwayi, n’aho ibizamini bikorerwa. Amakuru rusange yerekeye ibizamini byamavuriro nayo arahari.

Kuvura Icyiciro cya III nicyiciro cya IV Mycose Fungoides (Harimo na Sézary Syndrome)

Kumakuru yerekeye imiti yavuzwe hepfo, reba igice cyo kuvura.

Kuvura icyiciro gishya cya III nicyiciro cya IV mycose fungoide harimo na syndrome ya Sézary ni palliative (kugabanya ibimenyetso no kuzamura imibereho) kandi ishobora kuba ikubiyemo ibi bikurikira:

• Psoralen na ultraviolet A (PUVA) ivura imirasire.

• Ultraviolet B ivura imirasire.

• Extracorporeal Photochemotherapy yatanzwe wenyine cyangwa ihujwe nuruhu rwuzuye rwa elegitoroniki yumuriro.

• Imishwarara yimishwarara hamwe nubuvuzi bwuzuye uruhu rwa electron. Rimwe na rimwe, imiti ivura imirasire ihabwa ibikomere byuruhu, nkubuvuzi bwa palliative kugirango bugabanye ubunini bwibibyimba kugirango bigabanye ibimenyetso kandi bizamura imibereho.

• Immunotherapy yatanzwe wenyine cyangwa ihujwe nubuvuzi bwerekejwe kuruhu.

• Sisitemu ya chimiotherapie hamwe numuti umwe cyangwa nyinshi, zishobora guhuzwa nubuvuzi bwerekejwe kuruhu.

• Ubuvuzi bwa chimiotherapie.

• Ubundi buryo bwo kuvura ibiyobyabwenge (corticosteroide yibanze, lenalidomide, bexarotene, inhibitori ya histone deacetylase).

• Ubuvuzi bugamije hamwe na brentuximab vedotin.

Koresha ubushakashatsi bwamavuriro kugirango ushakishe NCI ifashwa na kanseri ivura abarwayi. Urashobora gushakisha ibigeragezo ukurikije ubwoko bwa kanseri, imyaka yumurwayi, n’aho ibizamini bikorerwa. Amakuru rusange yerekeye ibizamini byamavuriro nayo arahari.

Umuti wa Mycose Fungoide Yisubiramo (Harimo na Sézary Syndrome)

Kumakuru yerekeye imiti yavuzwe hepfo, reba igice cyo kuvura.

Indwara ya mycose fungoide na syndrome ya Sézary yagarutse muruhu cyangwa mubindi bice byumubiri nyuma yo kuvurwa.

Kuvura mycose fungoide isubirwamo harimo na syndrome ya Sézary irashobora kuba mubigeragezo byamavuriro kandi irashobora kubamo ibi bikurikira:

• Imishwarara yimishwarara hamwe nubuvuzi bwuzuye uruhu rwa electron. Rimwe na rimwe, imiti ivura imirasire ihabwa ibikomere byuruhu nka palliative therapy kugirango igabanye ubunini bwibibyimba kugirango igabanye ibimenyetso kandi imibereho myiza.

• Psoralen na ultraviolet A (PUVA) ivura imirasire, ishobora gutangwa hamwe na immunotherapie.

• Imirasire ya Ultraviolet B.

• Extracorporeal Photochemotherapy.

• Sisitemu ya chimiotherapie hamwe nibiyobyabwenge kimwe cyangwa byinshi.

• Ubundi buryo bwo kuvura imiti (corticosteroide yibanze, kuvura retinoide, lenalidomide, inhibitori ya histone deacetylase).

• Immunotherapy yatanzwe wenyine cyangwa ihujwe nubuvuzi bwerekejwe kuruhu.

• Chimiotherapie ikabije, kandi rimwe na rimwe ivura imirasire, hamwe no guterwa ingirangingo.

• Ubuvuzi bugamije (brentuximab vedotin cyangwa mogamulizumab).

Koresha ubushakashatsi bwamavuriro kugirango ushakishe NCI ifashwa na kanseri ivura abarwayi. Urashobora gushakisha ibigeragezo ukurikije ubwoko bwa kanseri, imyaka yumurwayi, n’aho ibizamini bikorerwa. Amakuru rusange yerekeye ibizamini byamavuriro nayo arahari.

Kumenya byinshi kuri Mycose Fungoides na Sézary Syndrome

Ushaka amakuru menshi yikigo cyigihugu cya kanseri kubyerekeye mycose fungoides na syndrome ya Sézary, reba ibi bikurikira:

• Urupapuro rwa Lymphoma

• Ubuvuzi bwa Photodynamic kuri Kanseri

• Ibiyobyabwenge Byemewe kuri Lymphoma itari Hodgkin

• Immunotherapy yo kuvura Kanseri

• Intego zo kuvura Kanseri

Kumakuru rusange ya kanseri nibindi bikoresho biva mu kigo cyigihugu cya kanseri, reba ibi bikurikira:

• Ibyerekeye Kanseri

• Gutegura

• Chimiotherapie nawe: Inkunga kubantu barwaye Kanseri

• Ubuvuzi bwimirasire nawe: Inkunga kubantu barwaye Kanseri

• Guhangana na Kanseri

• Ibibazo byo Kubaza Muganga wawe kuri Kanseri

• Abacitse ku icumu n'abarezi