Types/lymphoma/patient/adult-nhl-treatment-pdq

Abakuze Ntabwo Hodgkin Lymphoma Yivura (®) –Umurwayi

Amakuru Rusange Yerekeye Abakuze Non-Hodgkin Lymphoma

INGINGO Z'INGENZI

• Lymphoma itari Hodgkin ni indwara ingirabuzimafatizo (kanseri) zikora muri sisitemu ya lymph.

• Lymphoma itari Hodgkin irashobora kuba indakoreka cyangwa ikaze.

• Ubusaza, kuba umugabo, no kugira ubudahangarwa bw'umubiri birashobora kongera ibyago byo kurwara lymphoma ikuze itari Hodgkin.

• Ibimenyetso nibimenyetso bya lymphoma ikuze itari Hodgkin harimo kubyimba lymph node, kubyimba, kubira ibyuya nijoro, guta ibiro, n'umunaniro.

• Ibizamini bisuzuma sisitemu ya lymph nibindi bice byumubiri bikoreshwa mugufasha gusuzuma no gutera lymphoma ikuze itari Hodgkin.

• Ibintu bimwe bigira ingaruka kubitekerezo (amahirwe yo gukira) hamwe nuburyo bwo kuvura.

Lymphoma itari Hodgkin ni indwara ingirabuzimafatizo (kanseri) zikora muri sisitemu ya lymph.

Lymphoma itari Hodgkin ni ubwoko bwa kanseri ikora muri sisitemu ya lymph. Sisitemu ya lymph igizwe na sisitemu yumubiri. Ifasha kurinda umubiri kwandura n'indwara.

Sisitemu ya lymph igizwe nibi bikurikira:

• Lymph: Amazi adafite ibara, amazi atembera mumitsi ya lymph kandi atwara lymphocytes (selile yera). Hariho ubwoko butatu bwa lymphocytes:

• B lymphocytes B ikora antibodies zifasha kurwanya kwandura. Byitwa B selile. Ubwoko bwinshi bwa lymphoma itari Hodgkin itangirira muri lymphocytes B.

• T lymphocytes T ifasha lymphocytes B gukora antibodies zifasha kurwanya kwandura. Byitwa T selile.

• Ingirabuzimafatizo zica zitera kanseri na virusi. Yitwa kandi selile NK.

• Imiyoboro ya Lymph: Urusobe rw'imiyoboro yoroheje ikusanya lymph mu bice bitandukanye by'umubiri ikayisubiza mu maraso.

• Indimu ya Lymph: Inzira ntoya, imeze nk'ibishyimbo iyungurura lymph kandi ikabika selile yera ifasha kurwanya indwara n'indwara. Indimu ya Lymph iboneka murusobe rwimitsi ya lymph umubiri wose. Amatsinda ya lymph node aboneka mu ijosi, munsi yintoki, mediastinum, inda, pelvis, no mugituba.

• Ururenda: Urugingo rukora lymphocytes, rukabika uturemangingo tw'amaraso atukura na lymphocytes, muyungurura amaraso, no gusenya uturemangingo twa kera. Ururenda ruri ku ruhande rw'ibumoso rw'inda hafi y'igifu.

• Thymus: Urugingo T lymphocytes T ikura ikagwira. Tymus iri mu gituza inyuma yigituza.

• Tonsil: Imbaga ebyiri ntoya ya lymph tissue inyuma yumuhogo. Hano hari toni imwe kuri buri ruhande rw'umuhogo.

• Amagufa yo mu magufa: Uturemangingo tworoshye, twinshi hagati yamagufwa amwe, nk'amagufwa yo mu kibuno ndetse n'igituza. Uturemangingo twamaraso yera, selile zitukura, na platine bikozwe mumagufwa.

Anatomy ya sisitemu ya lymph, yerekana imiyoboro ya lymph ningingo zirimo lymph node, toni, tymus, spleen, hamwe namagufa. Lymph (fluid fluid) na lymphocytes zinyura mumitsi ya lymph no mumitsi ya lymphcytes aho lymphocytes zangiza ibintu byangiza. Lymph yinjira mumaraso binyuze mumitsi minini hafi yumutima.

Lymph tissue iboneka no mubindi bice byumubiri nko gutondeka inzira yigifu, bronchus, nuruhu. Kanseri irashobora gukwirakwira mu mwijima no mu bihaha.

Hariho ubwoko bubiri bwa lymphoma: Lymphoma ya Hodgkin na lymphoma itari Hodgkin. Iyi ncamake yerekeye kuvura lymphoma ikuze itari Hodgkin, harimo no gutwita.

Kumakuru yandi moko ya lymphoma, reba incamake ya ikurikira:

• Abakuze Bavura Lymphoblastique Leukemia (lymphoblastique lymphoma)

• Abakuze Hodgkin Lymphoma

• Kuvura Lymphoma bijyanye na sida

• Umwana Kuvura Lymphoma Ntabwo Hodgkin

• Kuvura indwara ya Lymphocytike idakira (lymphocytike lymphoma)

• Mycose Fungoides (Harimo na Sézary Syndrome) Kuvura (lymphoma ya T-selile)

• Ubuvuzi bwibanze bwa CNS Lymphoma

Lymphoma itari Hodgkin irashobora kuba indakoreka cyangwa ikaze.

Lymphoma itari Hodgkin ikura kandi ikwirakwira ku bipimo bitandukanye kandi irashobora kuba indakoreka cyangwa ikaze. Indimu ya lymphoma ikunda gukura no gukwirakwira buhoro, kandi ifite ibimenyetso bike. Lymphoma yibasira ikura kandi ikwirakwira vuba, kandi ifite ibimenyetso nibimenyetso bishobora gukomera. Ubuvuzi bwa lymphoma idahwitse kandi ikaze biratandukanye.

Iyi ncamake yerekeye ubwoko bukurikira bwa lymphoma itari Hodgkin:

Indolent non-Hodgkin lymphoma

Lymphoma. Lymphoma Follicular ni ubwoko busanzwe bwa lymphoma idafite ubushake. Nubwoko bukura buhoro cyane bwa lymphoma itari Hodgkin itangirira muri lymphocytes B. Ifata lymph node kandi irashobora gukwirakwira mu magufa cyangwa mu gihimba. Benshi mu barwayi barwaye lymphoma bafite imyaka 50 nayirenga iyo basuzumwe. Lymphoma Follicular irashobora kugenda itavuwe. Umurwayi akurikiranirwa hafi ibimenyetso cyangwa ibimenyetso byerekana ko indwara yagarutse. Umuti urakenewe niba ibimenyetso cyangwa ibimenyetso bibaye nyuma ya kanseri ibuze cyangwa nyuma yo kuvura kanseri ya mbere. Rimwe na rimwe, lymphoma ya follicular irashobora guhinduka ubwoko bwa lymphoma bukabije, nka diffuse nini ya B-selile lymphoma.

Lymphoplasmacytic lymphoma. Mubihe byinshi bya lymphoplasmacytic lymphoma, Lymphocytes B ihinduka selile selile ikora proteine ​​nyinshi yitwa antibody ya monoclonal immunoglobulin M (IgM) antibody. Antibody nyinshi ya IgM mumaraso itera plasma yamaraso kwiyongera. Ibi birashobora gutera ibimenyetso cyangwa ibimenyetso nkikibazo cyo kubona cyangwa kumva, ibibazo byumutima, guhumeka nabi, kubabara umutwe, guhindagurika, no kunanirwa cyangwa gutitira amaboko n'ibirenge. Rimwe na rimwe, nta bimenyetso cyangwa ibimenyetso bya lymphoplasmacytic lymphoma. Irashobora kuboneka mugihe isuzuma ryamaraso rikorwa kubwindi mpamvu. Lymphoplasmacytic lymphoma ikwirakwira mu magufa, imitsi ya lymph, na spleen. Abarwayi barwaye lymphoplasmacytic lymphoma bagomba gusuzumwa niba banduye virusi ya hepatite C. Yitwa kandi Waldenström macroglobulinemia.

Marginal zone lymphoma. Ubu bwoko bwa lymphoma itari Hodgkin itangirira muri B lymphocytes B mu gice cyama lymph bita marginal zone. Imenyekanisha rishobora kuba ribi ku barwayi bafite imyaka 70 cyangwa irenga, abafite icyiciro cya III cyangwa icyiciro cya IV, n'abafite urugero rwinshi rwa lahydate dehydrogenase (LDH). Hariho ubwoko butanu butandukanye bwa marginal zone lymphoma. Bashyizwe hamwe n'ubwoko bwa tissue aho lymphoma yashinze:

• Nodal marginal zone lymphoma. Nodal marginal zone lymphoma ikora muri lymph node. Ubu bwoko bwa lymphoma itari Hodgkin ni gake. Yitwa kandi monocytoid B-selile lymphoma.

• Gastric mucosa ifitanye isano na lymphoide tissue (MALT) lymphoma. Gastric MALT lymphoma mubisanzwe itangirira mu gifu. Ubu bwoko bwa marginal zone lymphoma ikora mungirangingo muri mucosa ifasha gukora antibodies. Abarwayi bafite lymphoma ya MALT yo mu gifu barashobora kandi kugira gastrite ya Helicobacter cyangwa indwara ya autoimmune, nka Hashimoto tiroyide ya Hashimoto cyangwa syndrome ya Sjögren.

• Indwara ya lymphoma idasanzwe. Lymphoma idasanzwe ya MALT itangirira hanze yigifu hafi ya buri gice cyumubiri harimo nibindi bice byinzira zifata gastrointestinal, glande salivary, tiroyide, ibihaha, uruhu, hamwe nijisho. Ubu bwoko bwa marginal zone lymphoma ikora mungirangingo muri mucosa ifasha gukora antibodies. Lymphoma idasanzwe ya MALT irashobora kugaruka nyuma yimyaka myinshi nyuma yo kuvurwa.

• Lymphoma yo mu nda ya Mediterane. Ubu ni ubwoko bwa lymphoma MALT iboneka mu rubyiruko rukuze mu burasirazuba bwa Mediterane. Bikunze kwibera munda kandi abarwayi bashobora no kwandura bagiteri yitwa Campylobacter jejuni. Ubu bwoko bwa lymphoma nabwo bwitwa immunoproliferative indwara ntoya yo munda.

• Splenic marginal zone lymphoma. Ubu bwoko bwa marginal zone lymphoma butangirira mu gihimba kandi bushobora gukwirakwira mu maraso ya peripheri no mu magufa. Ikimenyetso gikunze kugaragara muri ubu bwoko bwa splenic marginal zone lymphoma ni ururenda runini kuruta ibisanzwe.

Primary cutaneous anaplastique selile lymphoma. Ubu bwoko bwa lymphoma itari Hodgkin iri muruhu gusa. Irashobora kuba nodule nziza (ntabwo ari kanseri) ishobora kugenda yonyine cyangwa irashobora gukwirakwira ahantu henshi kuruhu kandi ikeneye kuvurwa.

Indwara ya lymphoma itari Hodgkin

Diffuse nini ya B-selile lymphoma. Diffuse nini ya B-selile lymphoma nubwoko busanzwe bwa lymphoma itari Hodgkin. Irakura vuba mumitsi ya lymph kandi akenshi ururenda, umwijima, igufwa, cyangwa izindi ngingo nabyo bigira ingaruka. Ibimenyetso nibimenyetso byo gukwirakwiza lymphoma nini ya B irashobora kuba irimo umuriro, kubira ibyuya nijoro, no kugabanya ibiro. Ibi byitwa kandi ibimenyetso bya B.

• Primary mediastinal nini B-selile lymphoma. Ubu bwoko bwa lymphoma itari Hodgkin ni ubwoko bwa diffuse nini ya B-selile lymphoma. Irangwa no gukura kwa fibrous (inkovu-imeze) lymph tissue. Ikibyimba gikunze kugaragara inyuma yigituza. Irashobora gukanda kumuyaga kandi igatera inkorora no guhumeka neza. Abenshi mu barwayi bafite lymphoma nini ya mediastinal nini ni abagore bafite imyaka 30 kugeza 40.

Follicular selile lymphoma, icyiciro cya III. Follicular selile lymphoma, icyiciro cya III, ni ubwoko budasanzwe bwa lymphoma itari Hodgkin. Kuvura ubu bwoko bwa lymphoma ya follicular ni nko kuvura NHL ikaze kuruta NHL idashaka.

Anaplastique nini ya lymphoma. Anaplastique nini ya lymphoma ni ubwoko bwa lymphoma itari Hodgkin ikunze gutangirira muri Lymphocytes T. Ingirabuzimafatizo za kanseri nazo zifite ikimenyetso cyitwa CD30 hejuru ya selile.

Hariho ubwoko bubiri bwa lymphoma nini ya anaplastique:

• Cutaneous anaplastique nini ya lymphoma. Ubu bwoko bwa lymphoma nini ya anaplastique yibasira cyane uruhu, ariko ibindi bice byumubiri nabyo bishobora kugira ingaruka. Ibimenyetso bya lymphoma nini ya selile anaplastique irimo kimwe cyangwa byinshi byabyimbye cyangwa ibisebe kuruhu. Ubu bwoko bwa lymphoma ni gake kandi ntibushake.

• Sisitemu ya anaplastique nini ya lymphoma. Ubu bwoko bwa lymphoma nini ya anaplastique itangirira mumyanya ya lymph kandi irashobora kugira ingaruka kubindi bice byumubiri. Ubu bwoko bwa lymphoma burakaze. Abarwayi barashobora kugira proteine ​​nyinshi za anaplastique lymphoma kinase (ALK) imbere muri selile lymphoma. Aba barwayi bafite prognoza nziza kurusha abarwayi badafite proteine ​​ya ALK yiyongera. Sisitemu ya anaplastique nini ya lymphoma ikunze kugaragara mubana kurusha abantu bakuru. (Reba incamake ya kubyerekeranye no kuvura Lymphoma yo mu bwana itari Hodgkin kubindi bisobanuro.)

• Extranodal NK- / T-selile lymphoma. Extranodal NK- / T-selile lymphoma mubisanzwe itangirira mukarere kazuru. Irashobora kandi kugira ingaruka kuri sinus ya paranasal (umwanya wuzuye mumagufwa azengurutse izuru), igisenge cyumunwa, trachea, uruhu, igifu, n amara. Indwara nyinshi za lymphoma zidasanzwe NK- / T-selile zifite virusi ya Epstein-Barr muri selile yibibyimba. Rimwe na rimwe, syndrome de hemophagocytic ibaho (ibintu bikomeye aho usanga hariho histiocytes nyinshi na selile T zitera umuriro mwinshi mumubiri). Umuti wo guhagarika sisitemu yumubiri urakenewe. Ubu bwoko bwa lymphoma itari Hodgkin ntabwo busanzwe muri Amerika.

• Lymphomatoid granulomatose. Lymphomatoid granulomatose yibasira cyane ibihaha. Irashobora kandi kugira ingaruka kuri sinus ya paranasal (umwanya wuzuye mumagufwa azengurutse izuru), uruhu, impyiko, hamwe na sisitemu yo hagati. Muri lymphomatoide granulomatose, kanseri yibasira imiyoboro y'amaraso ikica ingirangingo. Kubera ko kanseri ishobora gukwirakwira mu bwonko, hatangwa imiti ya chimiotherapie cyangwa imiti ivura ubwonko ihabwa ubwonko.

• Angioimmunoblastique T-selile lymphoma. Ubu bwoko bwa lymphoma itari Hodgkin itangirira muri selile T. Lymph node yabyimbye nikimenyetso rusange. Ibindi bimenyetso bishobora kubamo uruhu, umuriro, kugabanuka, cyangwa ibyuya byijoro. Hashobora no kuba urugero rwinshi rwa gamma globuline (antibodies) mumaraso. Abarwayi barashobora kandi kwandura amahirwe kuko sisitemu yumubiri yabo igabanuka.

• Periferique T-selile lymphoma. Periferique T-selile lymphoma itangirira muri lymphocytes T ikuze. Ubu bwoko bwa Lymphocyte T burakura muri glande ya thymus kandi bukajya mubindi bibanza byitwa lymphatique mumubiri nka lymph node, marrow bone, na spleen. Hariho uburyo butatu bwa periferique T-selile lymphoma:

• Hepatosplenic T-selile lymphoma. Ubu ni ubwoko budasanzwe bwa lymphoma ya T-selile igaragara cyane mubasore. Bitangirira mu mwijima no mu gihimba kandi kanseri ya kanseri nayo ifite reseptor ya T-selile yitwa gamma / delta hejuru ya selile.

• Subcutaneous panniculitis isa na T-selile lymphoma. Subcutaneous panniculitis isa na T-selile lymphoma itangirira kuruhu cyangwa mucosa. Irashobora kubaho hamwe na syndrome de hemophagocytic (ibintu bikomeye aho usanga hariho histiocytes nyinshi na T selile zitera uburibwe bukabije mumubiri). Umuti wo guhagarika sisitemu yumubiri urakenewe.

• Enteropathie-ubwoko bw'amara T-selile lymphoma. Ubu bwoko bwa lymphoma ya periferique T iboneka mu mara mato y’abarwayi bafite indwara ya celiac itavuwe (igisubizo cy’ubudahangarwa kuri gluten itera imirire mibi). Abarwayi basuzumwe n'indwara ya celiac mu bwana kandi bakaguma ku ndyo idafite gluten ntibakunze kugira indwara yo mu bwoko bwa enteropathie yo mu nda T-lymphoma.

• Imitsi nini ya B-selile lymphoma. Ubu bwoko bwa lymphoma itari Hodgkin yibasira imiyoboro y'amaraso, cyane cyane imiyoboro mito y'amaraso mu bwonko, impyiko, ibihaha, ndetse n'uruhu. Ibimenyetso nibimenyetso bya lymphoma nini ya B-selile iterwa nimiyoboro y'amaraso ifunze. Yitwa kandi lymphomatose yo mu nda.

• Burkitt lymphoma.Lymphoma ya Burkitt ni ubwoko bwa B-selile itari Hodgkin lymphoma ikura kandi ikwirakwira vuba. Irashobora kugira ingaruka ku rwasaya, amagufwa yo mu maso, amara, impyiko, intanga ngore, cyangwa izindi ngingo. Hariho ubwoko butatu bwingenzi bwa lymphoma ya Burkitt (endemic, sporadic, na immunodeficiency bifitanye isano). Indwara ya lymphoma ya Endemic ikunze kugaragara muri Afurika kandi ifitanye isano na virusi ya Epstein-Barr, kandi lymphoma ya Burkitt rimwe na rimwe ibaho ku isi hose. Immunodeficiency ifitanye isano na Burkitt lymphoma ikunze kugaragara ku barwayi bafite sida. Lymphoma ya Burkitt irashobora gukwirakwira mu bwonko no mu ruti rw'umugongo no kuvura kugirango ikwirakwizwa. Lymphoma ya Burkitt iboneka cyane mubana ndetse nabakuze (Reba incamake ya kubuvuzi bwa Lymphoma bwabana bato)

• Lymphoblastique lymphoma. Lymphoblastique lymphoma irashobora gutangirira muri selile T cyangwa B, ariko mubisanzwe itangirira muri selile T. Muri ubu bwoko bwa lymphoma itari Hodgkin, hariho lymphoblasts nyinshi (selile yera yera idakuze) mumitsi ya lymph na glande ya thymus. Iyi lymphoblasts irashobora gukwirakwira ahandi hantu mu mubiri, nko mu magufa, mu bwonko, no mu ruti rw'umugongo. Lymphoblastique lymphoma ikunze kugaragara cyane mubyangavu nabakuze. Nibyinshi nka lymphoblastique ikaze ya leukemia (lymphoblasts iboneka cyane mumagufwa namaraso). (Reba incamake ya kumiti ikuze ya Lymphoblastique Leukemia ivura amakuru menshi.)

• Abakuze T-selile leukemia / lymphoma. Abakuze T-selile leukemia / lymphoma iterwa na virusi ya T-selile yumuntu ubwoko bwa 1 (HTLV-1). Ibimenyetso birimo ibikomere byamagufa nuruhu, urugero rwinshi rwa calcium yamaraso, hamwe na lymph node, spleen, numwijima binini kuruta ibisanzwe.

• Mantle selile lymphoma. Lymphoma ya Mantle ni ubwoko bwa B-selile itari Hodgkin lymphoma ikunze kugaragara mubantu bakuze cyangwa bakuru. Itangirira mu mitsi ya lymph ikwirakwira mu gihimba, mu magufa, mu maraso, ndetse rimwe na rimwe esofagus, igifu, n'amara. Abarwayi bafite lymphoma ya mantle bafite proteine ​​nyinshi cyane yitwa cyclin-D1 cyangwa ihinduka rya gene runaka muri selile lymphoma. Mu barwayi bamwe badafite ibimenyetso cyangwa ibimenyetso bya lymphoma itinda gutangira kwivuza ntabwo bigira ingaruka kubimenyekanisha.

• Indwara ya posttransplantation lymphoproliferative disorder. Iyi ndwara ibaho ku barwayi bafite umutima, ibihaha, umwijima, impyiko, cyangwa pancreas transplant kandi bakeneye imiti ikingira ubuzima bwabo bwose. Indwara nyinshi ziterwa na lymphoproliferative yibasira selile B kandi ikagira virusi ya Epstein-Barr muri selile. Indwara ya Lymphoproliferative ikunze gufatwa nka kanseri.

• Lymphoma yukuri. Ubu ni ubwoko budasanzwe, bukabije bwa lymphoma. Ntabwo bizwi niba bitangirira muri B selile cyangwa T. Ntabwo isubiza neza kuvura hamwe na chimiotherapie isanzwe.

• Lymphoma yibanze. Lymphoma yibanze itangirira muri selile B iboneka ahantu hari ubwinshi bwamazi menshi, nkibice biri hagati yumurongo wibihaha nurukuta rwigituza (pleural effusion), isakoshi ikikije umutima numutima (pericardial effusion), cyangwa mumyanya yinda. Mubisanzwe nta kibyimba gishobora kugaragara. Ubu bwoko bwa lymphoma bukunze kugaragara ku barwayi banduye virusi itera SIDA.

• Lymphoma ya plasma. Lymphoma ya Plasmablastique ni ubwoko bwa B-selile nini ya Hodgkin lymphoma ikaze cyane. Bikunze kugaragara cyane ku barwayi banduye virusi itera SIDA.

Ubusaza, kuba umugabo, no kugira ubudahangarwa bw'umubiri birashobora kongera ibyago byo kurwara lymphoma ikuze itari Hodgkin.

Ikintu cyose cyongera ibyago byo kwandura byitwa impanuka. Kugira ibintu bishobora guteza ibyago ntibisobanura ko uzarwara kanseri; kutagira ibyago bishobora gusobanura ko utazarwara kanseri. Vugana na muganga wawe niba utekereza ko ushobora guhura n'akaga.

Izi mpamvu nizindi mpamvu zishobora kongera ibyago byubwoko bumwebumwe bwabantu bakuru lymphoma itari Hodgkin:

• Kuba mukuru, umugabo, cyangwa umweru.

• Kugira kimwe mubuvuzi bukurikira bugabanya intege nke z'umubiri:

• Indwara ikingira indwara (nka hypogammaglobulinemia cyangwa syndrome ya Wiskott-Aldrich).

• Indwara ya autoimmune (nka rubagimpande ya rubagimpande, psoriasis, cyangwa syndrome ya Sjögren).

• VIH / SIDA.

• Umuntu wanduye T-lymphotrophique Ubwoko bwa I cyangwa Epstein-Barr virusi.

• Indwara ya Helicobacter pylori.

• Gufata imiti ikingira indwara nyuma yo guterwa urugingo.

Ibimenyetso nibimenyetso bya lymphoma ikuze itari Hodgkin harimo kubyimba lymph node, kubyimba, kubira ibyuya nijoro, guta ibiro, n'umunaniro.

Ibi bimenyetso nibimenyetso bishobora guterwa na lymphoma ikuze itari Hodgkin cyangwa nibindi bihe. Menyesha umuganga wawe niba ufite kimwe muri ibi bikurikira:

• Kubyimba mu mitsi ya lymph mu ijosi, munsi yintoki, igituba, cyangwa igifu.

• Umuriro nta mpamvu izwi.

• Kuruha ibyuya nijoro.

• Kumva unaniwe cyane.

• Kugabanya ibiro nta mpamvu izwi.

• Uruhu rwihuta cyangwa uruhu.

• Kubabara mu gituza, munda, cyangwa amagufwa nta mpamvu izwi.

• Iyo umuriro, kubira ibyuya nijoro, no kugabanya ibiro bibaye hamwe, iri tsinda ryibimenyetso ryitwa ibimenyetso B.

Ibindi bimenyetso nibimenyetso bya lymphoma ikuze itari Hodgkin irashobora kubaho kandi biterwa nibi bikurikira:

• Aho kanseri yibera mumubiri.

• Ingano yikibyimba.

• Ukuntu ikibyimba gikura vuba.

Ibizamini bisuzuma sisitemu ya lymph nibindi bice byumubiri bikoreshwa mugufasha gusuzuma no gutera lymphoma ikuze itari Hodgkin.

Ibizamini hamwe nuburyo bukurikira birashobora gukoreshwa:

• Ikizamini cyumubiri namateka yubuzima: Ikizamini cyumubiri kugirango ugenzure ibimenyetso rusange byubuzima, harimo no gusuzuma ibimenyetso byindwara, nkibibyimba cyangwa ikindi kintu cyose gisa nkidasanzwe. Hazafatwa kandi amateka yubuzima bwumurwayi, harimo umuriro, ibyuya nijoro, no kugabanya ibiro, ingeso zubuzima, nindwara zashize hamwe nubuvuzi.

• Kubara amaraso yuzuye (CBC): Uburyo bwo gukuramo urugero rwamaraso no gusuzuma ibi bikurikira:

• Umubare w'uturemangingo tw'amaraso atukura, selile yera, na platine.

• Ingano ya hemoglobine (proteyine itwara ogisijeni) mu ngirangingo z'amaraso atukura.

• Igice cy'icyitegererezo kigizwe na selile zitukura.

Kubara amaraso yuzuye (CBC). Amaraso akusanywa no kwinjiza inshinge mumitsi no kwemerera amaraso gutembera mumiyoboro. Icyitegererezo cyamaraso cyoherezwa muri laboratoire hanyuma selile zitukura, selile yera, na platine zirabaze. CBC ikoreshwa mugupima, gusuzuma, no gukurikirana ibintu byinshi bitandukanye.

• Ubushakashatsi bwa chimie yamaraso: Uburyo bwo gusuzuma urugero rwamaraso kugirango bapime urugero rwibintu bimwe na bimwe bisohoka mumaraso ningingo nuduce twumubiri. Umubare udasanzwe (uri hejuru cyangwa uri munsi yubusanzwe) ibintu bishobora kuba ikimenyetso cyindwara.

• Ikizamini cya LDH: Uburyo bwo gusuzuma urugero rwamaraso kugirango bapime urugero rwa dehydrogenase ya lactique. Ubwiyongere bwa LDH mumaraso bushobora kuba ikimenyetso cyangirika kwinyama, lymphoma, cyangwa izindi ndwara.

• Ikizamini cya Hepatite B na hepatite C: Uburyo bwo gusuzuma urugero rwamaraso kugirango bapime ingano ya virusi yihariye ya virusi ya hepatite B na / cyangwa antibodi hamwe nubunini bwa virusi ya hepatite C. Izi antigene cyangwa antibodies bita marikeri. Ibimenyetso bitandukanye cyangwa guhuza ibimenyetso bikoreshwa kugirango hamenyekane niba umurwayi afite hepatite B cyangwa C, yaba yaranduye mbere cyangwa inkingo, cyangwa ashobora kwandura. Abarwayi bavuwe virusi ya hepatite B mu bihe byashize bakeneye gukomeza gukurikiranwa kugira ngo barebe niba yongeye gukora. Kumenya niba umuntu arwaye hepatite B cyangwa C birashobora gufasha kuvura.

• Kwipimisha virusi itera sida: Ikizamini cyo gupima urugero rwa antibodi ya virusi itera sida. Antibodies zikorwa numubiri iyo zatewe nibintu byamahanga. Urwego rwo hejuru rwa antibodiyite ya sida rushobora gusobanura ko umubiri wanduye virusi itera sida.

• CT scan (CAT scan): Uburyo bukora urukurikirane rwamashusho arambuye yibice byimbere mumubiri, nk'ijosi, igituza, inda, pelvis, na lymph node, byafashwe muburyo butandukanye. Amashusho yakozwe na mudasobwa ihujwe na mashini ya x-ray. Irangi rishobora guterwa mumitsi cyangwa kumirwa kugirango bifashe ingingo cyangwa ingirangingo kugaragara neza. Ubu buryo nabwo bwitwa computing tomografiya, tomografiya ya mudasobwa, cyangwa mudasobwa ya axial tomografiya.

• PET scan (positron emission tomografi scan): Uburyo bwo kubona selile mbi yibibyimba mumubiri. Umubare muto wa glucose ikora radio (isukari) yatewe mumitsi. PET scaneri izenguruka umubiri kandi ikora ishusho yerekana aho glucose ikoreshwa mumubiri. Utugingo ngengabuzima twibibyimba twerekana neza cyane ku ishusho kuko zikora cyane kandi zifata glucose nyinshi kuruta selile zisanzwe.

• Amagufa ya marrow aspiration na biopsy: Gukuraho igufwa ryamagufwa nigice gito cyamagufwa winjiza urushinge mumatako cyangwa kumabere. Inzobere mu by'indwara ireba igufwa n'amagufwa munsi ya microscope kugira ngo ishakishe ibimenyetso bya kanseri.

Amagufa ya marrow icyifuzo na biopsy. Nyuma yuko agace gato k'uruhu kamaze kunanirwa, urushinge rw'amagufwa rwinjizwa mu igufwa ry'umurwayi. Ingero z'amaraso, amagufwa, n'amagufwa byavanyweho kugirango bisuzumwe kuri microscope.

• Lymph node biopsy: Gukuraho ibintu byose cyangwa igice cya lymph node. Inzobere mu bijyanye n’indwara ireba ingirabuzimafatizo ziri munsi ya microscope kugira ngo isuzume kanseri ya kanseri. Bumwe mu bwoko bukurikira bwa biopsies burashobora gukorwa:

• Biopsy idasanzwe: Gukuraho lymph node yose.

• Biopsy incisional: Gukuraho igice cya lymph node.

• Core biopsy: Gukuraho igice cya lymph node ukoresheje urushinge rugari.

Niba kanseri ibonetse, ibizamini bikurikira birashobora gukorwa kugirango bige kanseri ya kanseri:

• Immunohistochemie: Ikizamini cya laboratoire ikoresha antibodies kugirango igenzure antigene zimwe na zimwe (marikeri) mu cyitegererezo cyumubiri wumurwayi. Antibodies zisanzwe zifitanye isano na enzyme cyangwa irangi rya fluorescent. Antibodies zimaze guhuza antigen yihariye murugero rwa tissue, enzyme cyangwa irangi irakora, hanyuma antigen irashobora kuboneka munsi ya microscope. Ubu bwoko bwikizamini bukoreshwa mugufasha gusuzuma kanseri no gufasha kubwira ubwoko bumwe bwa kanseri buva mubundi bwoko bwa kanseri.

• Isesengura rya Cytogenetike: Ikizamini cya laboratoire kibarwa chromosomes yingirabuzimafatizo mu cyitegererezo cyamaraso cyangwa igufwa ryamagufwa ikabarwa kandi ikagenzurwa niba hari impinduka, nko kuvunika, kubura, gutondekanya, cyangwa chromosomes ziyongera. Impinduka muri chromosomes zimwe zishobora kuba ikimenyetso cya kanseri. Isesengura rya Cytogenetike rikoreshwa mu gufasha gusuzuma kanseri, gutegura gahunda yo kuvura, cyangwa kumenya uburyo ubuvuzi bukora neza.

• Immunophenotyping: Ikizamini cya laboratoire ikoresha antibodies kugirango hamenyekane kanseri ya kanseri ukurikije ubwoko bwa antigene cyangwa ibimenyetso hejuru ya selile. Iki kizamini gikoreshwa mugufasha gusuzuma ubwoko bwihariye bwa lymphoma.

• AMAFI (fluorescence in situ hybridisation): Ikizamini cya laboratoire ikoreshwa mu kureba no kubara gen cyangwa chromosomes mu ngirabuzimafatizo no mu ngingo. Ibice bya ADN birimo amarangi ya fluorescent bikozwe muri laboratoire hanyuma bikongerwaho icyitegererezo cy'uturemangingo cyangwa ingirangingo z'umurwayi. Iyo ibyo bice bisize irangi bya ADN bifatanye na genes cyangwa uduce twa chromosomes murugero, biramurika iyo urebye munsi ya microscope ya fluorescent. Ikizamini cya FISH gikoreshwa mugufasha gusuzuma kanseri no gufasha kuvura.

Ibindi bizamini hamwe nuburyo bishobora gukorwa bitewe nibimenyetso nibimenyetso bigaragara naho kanseri ikorera mumubiri.

Ibintu bimwe bigira ingaruka kubitekerezo (amahirwe yo gukira) hamwe nuburyo bwo kuvura.

Amahitamo yo kuvura no kuvura biterwa nibi bikurikira:

• Ibimenyetso byumurwayi nibimenyetso, harimo niba bafite ibimenyetso B (umuriro nta mpamvu izwi, kugabanuka ibiro nta mpamvu izwi, cyangwa ibyuya byijoro).

• Icyiciro cya kanseri (ingano y'ibibyimba bya kanseri kandi niba kanseri yarakwirakwiriye mu bindi bice by'umubiri cyangwa lymph node).

• Ubwoko bwa lymphoma itari Hodgkin.

• Ingano ya lactate dehydrogenase (LDH) mumaraso.

• Niba hari impinduka zimwe na zimwe muri gen.

• Imyaka yumurwayi, igitsina, nubuzima rusange.

• Niba lymphoma isuzumwe vuba, ikomeza gukura mugihe cyo kuvura, cyangwa yagarutse (garuka).

Kuri lymphoma itari Hodgkin mugihe utwite, uburyo bwo kuvura nabwo buterwa na:

• Ibyifuzo byumurwayi.

• Nibihe bitatu byo gutwita umurwayi arimo.

• Niba umwana ashobora kubyara hakiri kare.

Ubwoko bumwebumwe bwa lymphoma butari Hodgkin bukwirakwira vuba kurenza ubundi. Lymphoma nyinshi zitari Hodgkin zibaho mugihe cyo gutwita zirakara. Gutinda kuvura lymphoma ikaze kugeza umwana amaze kuvuka birashobora kugabanya amahirwe yo kubaho kwa nyina. Kuvurwa bidatinze, akenshi no gutwita.

Ibyiciro by'abakuze Non-Hodgkin Lymphoma

INGINGO Z'INGENZI

• Nyuma yo gupimwa lymphoma ikuze itari Hodgkin, hakorwa ibizamini kugirango hamenyekane niba kanseri ya kanseri yakwirakwiriye muri sisitemu ya lymph cyangwa mu bindi bice by'umubiri.

• Hariho uburyo butatu kanseri ikwirakwira mu mubiri.

• Ibyiciro bikurikira bikoreshwa kubakuze lymphoma itari Hodgkin:

• Icyiciro I.

• Icyiciro cya II

• Icyiciro cya III

• Icyiciro cya IV

• Gusubiramo Abakuze Non-Hodgkin Lymphoma

• Lymphoma ikuze itari Hodgkin irashobora guhurizwa hamwe kugirango ivurwe ukurikije niba kanseri idashaka cyangwa ikaze, yaba lymph node yibasiwe iruhande rwumubiri, kandi niba kanseri yarasuzumwe cyangwa ikongera.

Nyuma yo gupimwa lymphoma ikuze itari Hodgkin, hakorwa ibizamini kugirango hamenyekane niba kanseri ya kanseri yakwirakwiriye muri sisitemu ya lymph cyangwa mu bindi bice by'umubiri.

Inzira ikoreshwa mu kumenya ubwoko bwa kanseri kandi niba kanseri ya kanseri yarakwirakwiriye muri sisitemu ya lymph cyangwa mu bindi bice byumubiri byitwa guterana. Amakuru yakusanyirijwe mubikorwa byateguwe agena icyiciro cyindwara. Ni ngombwa kumenya icyiciro cyindwara kugirango utegure kuvura. Ibisubizo by'ibizamini n'inzira zakozwe mu gusuzuma lymphoma itari Hodgkin ikoreshwa mu gufasha gufata ibyemezo bijyanye no kuvura.

Ibizamini hamwe nuburyo bukurikira birashobora no gukoreshwa mugutegura:

• MRI . Ikintu cyitwa gadolinium cyatewe mumurwayi binyuze mumitsi. Gadolinium ikusanyiriza hafi ya kanseri ya kanseri kugirango igaragare neza ku ishusho. Ubu buryo bwitwa kandi magnetic magnetic resonance imaging (NMRI).

• Gutobora Lumbar: Uburyo bukoreshwa mu gukusanya amazi ya cerebrospinal fluid (CSF) kuva kumugongo. Ibi bikorwa mugushira urushinge hagati yamagufa abiri murugongo no muri CSF ikikije uruti rwumugongo no gukuramo icyitegererezo cyamazi. Icyitegererezo cya CSF gisuzumwa munsi ya microscope kugirango ibimenyetso byerekana ko kanseri yakwirakwiriye mu bwonko no mu ruti rw'umugongo. Ubu buryo bwitwa LP cyangwa igikanda.

Gutobora. Umurwayi aryamye mumwanya uhetamye kumeza. Nyuma yumwanya muto kumugongo wo hasi ucecetse, urushinge rwumugongo (urushinge rurerure, ruto) rwinjizwa mubice byo hepfo yinkingi yumugongo kugirango rukureho ubwonko bwubwonko (CSF, bwerekanwe mubururu). Amazi arashobora koherezwa muri laboratoire kugirango isuzumwe.

Ku bagore batwite bafite lymphoma itari Hodgkin, hakoreshwa ibizamini hamwe nuburyo bukingira umwana utaravuka ingaruka z’imishwarara. Ibi bizamini hamwe nibikorwa birimo MRI (ntaho bihuriye), gucumita, na ultrasound.

Hariho uburyo butatu kanseri ikwirakwira mu mubiri. Kanseri irashobora gukwirakwira binyuze mu ngingo, sisitemu ya lymph, n'amaraso:

• Tissue. Kanseri ikwirakwira aho yatangiriye ikurira mu turere twegereye.

• Sisitemu ya Lymph. Kanseri ikwirakwira aho yatangiriye yinjira muri sisitemu ya lymph. Kanseri inyura mu mitsi ya lymph igana mu bindi bice by'umubiri.

• Amaraso. Kanseri ikwirakwira aho yatangiriye yinjira mu maraso. Kanseri inyura mu mitsi y'amaraso igana mu bindi bice by'umubiri.

Ibyiciro bikurikira bikoreshwa kubakuze lymphoma itari Hodgkin:

Icyiciro I.

Icyiciro cya I lymphoma ikuze. Kanseri iboneka muri lymph node imwe cyangwa nyinshi mumatsinda ya lymph node, cyangwa, gake, kanseri iboneka mumpeta ya Waldeyer, thymus, cyangwa spleen. Mu cyiciro cya IE (kiterekanwa), kanseri yakwirakwiriye mu gace kamwe ka sisitemu ya lymph.

Icyiciro cya I abakuze lymphoma itari Hodgkin igabanijwe mubice I na IE.

Mu cyiciro cya I, kanseri iboneka muri hamwe mu buryo bukurikira muri sisitemu ya lymph:

• Imwe cyangwa nyinshi ya lymph node mumatsinda ya lymph node.

• Impeta ya Waldeyer.

• Tymus.

• Intanga.

Mu cyiciro cya IE, kanseri iboneka ahantu hamwe hanze ya sisitemu ya lymph.

Icyiciro cya II

Icyiciro cya II abakuze lymphoma itari Hodgkin igabanijwemo ibyiciro II na IIE.

• Mu cyiciro cya II, kanseri iboneka mu matsinda abiri cyangwa menshi ya lymph node iri hejuru ya diafragma cyangwa munsi ya diafragma.

Icyiciro cya II lymphoma ikuze. Kanseri iboneka mu matsinda abiri cyangwa menshi ya lymph node iri hejuru ya diafragma cyangwa munsi ya diafragma.

• Mu cyiciro cya IIE, kanseri yakwirakwiriye mu itsinda rya lymph node kugera mu gace kegereye kari hanze ya sisitemu ya lymph. Kanseri irashobora gukwirakwira mu yandi matsinda ya lymph node kuruhande rumwe rwa diafragma.

Icyiciro cya IIE lymphoma ikuze. Kanseri yakwirakwiriye mu itsinda rya lymph node kugera ahantu hegereye hanze ya sisitemu ya lymph. Kanseri irashobora gukwirakwira mu yandi matsinda ya lymph node kuruhande rumwe rwa diafragma.

Mu cyiciro cya II, ijambo indwara nini ryerekeza ku mubyimba munini. Ingano yibibyimba byitwa indwara nini iratandukanye bitewe n'ubwoko bwa lymphoma.

Icyiciro cya III

Icyiciro cya III lymphoma ikuze. Kanseri iboneka mu matsinda ya lymph node haba hejuru no munsi ya diafragma; cyangwa mumatsinda ya lymph node hejuru ya diaphragm no mumutwe.

Mu cyiciro cya III lymphoma ikuze itari Hodgkin, kanseri iboneka:

• mu matsinda ya lymph node haba hejuru no munsi ya diafragma; cyangwa

• muri lymph node hejuru ya diaphragm no mumutwe.

Icyiciro cya IV

Icyiciro cya IV lymphoma ikuze. Kanseri (a) yakwirakwiriye mu ngingo imwe cyangwa nyinshi hanze ya sisitemu ya lymph; cyangwa (b) iboneka mu matsinda abiri cyangwa menshi ya lymph node iri hejuru ya diafragma cyangwa munsi ya diafragma no mu rugingo rumwe ruri hanze ya lymph kandi rutari hafi ya lymph node; cyangwa (c) iboneka mumatsinda ya lymph node hejuru ya diafragma no munsi ya diafragma no mubice byose biri hanze ya sisitemu ya lymph; cyangwa (d) iboneka mu mwijima, mu magufa, ahantu henshi mu bihaha, cyangwa mu bwonko bwa cerebrospinal (CSF). Kanseri ntiyakwirakwiriye mu mwijima, mu magufa, mu bihaha, cyangwa CSF kuva hafi ya lymph node.

Mu cyiciro cya IV abantu bakuze atari lymphoma ya Hodgkin, kanseri:

• yakwirakwiriye mu ngingo imwe cyangwa nyinshi hanze ya lymph sisitemu; cyangwa

• iboneka mu matsinda abiri cyangwa menshi ya lymph node iri hejuru ya diafragma cyangwa munsi ya diafragma no mu rugingo rumwe ruri hanze ya lymph kandi rutari hafi ya lymph node; cyangwa

• iboneka mumatsinda ya lymph node haba hejuru no munsi ya diafragma no mubice byose biri hanze ya sisitemu ya lymph; cyangwa

• iboneka mu mwijima, mu magufa, ahantu henshi mu bihaha, cyangwa mu bwonko bwa cerebrospinal (CSF). Kanseri ntiyakwirakwiriye mu mwijima, mu magufa, mu bihaha, cyangwa CSF kuva hafi ya lymph node.

Gusubiramo Abakuze Non-Hodgkin Lymphoma

Indwara ya lymphoma ikuze itari Hodgkin ni kanseri yagarutse (garuka) imaze kuvurwa. Lymphoma irashobora kugaruka muri sisitemu ya lymph cyangwa mubindi bice byumubiri. Indwara ya lymphoma irashobora kugaruka nka lymphoma ikaze. Lymphoma yibabaza irashobora kugaruka nka lymphoma idahwitse.

Lymphoma ikuze itari Hodgkin irashobora guhurizwa hamwe kugirango ivurwe ukurikije niba kanseri idashaka cyangwa ikaze, yaba lymph node yibasiwe iruhande rwumubiri, kandi niba kanseri yarasuzumwe cyangwa ikongera.

Reba amakuru rusange kumakuru yandi makuru yubwoko bwa indlentent (gukura buhoro) no gutera (gukura vuba) lymphoma itari Hodgkin.

Lymphoma itari Hodgkin irashobora kandi gusobanurwa nkaho ihurira cyangwa idahuza:

• Lymphoma ihuza: Lymphoma aho lymph node hamwe na kanseri iri iruhande.

• Lymphoma idahuza: Lymphoma aho lymph node hamwe na kanseri itari iruhande rwayo, ariko iri kuruhande rumwe rwa diafragma.

Incamake yo kuvura

INGINGO Z'INGENZI

• Hariho uburyo butandukanye bwo kuvura abarwayi bafite lymphoma itari Hodgkin.

• Abarwayi bafite lymphoma itari Hodgkin bagomba gutegurwa nubuvuzi bwitsinda ryabatanga ubuvuzi ninzobere mu kuvura

• lymphoma.

• Umuti wa lymphoma ukuze utari Hodgkin urashobora gutera ingaruka.

• Imiti ivura imirasire

• Chimoterapi

• Immunotherapy

• Ubuvuzi bugamije

• Plasmapheresis

• Gutegereza neza

• Ubuvuzi bwa antibiyotike

• Kubaga

• Gutera ingirabuzimafatizo

• Ubwoko bushya bwo kuvura burimo kugeragezwa mubigeragezo byamavuriro.

• Ubuvuzi bw'inkingo

• Abarwayi barashobora kwifuza gutekereza kubijyanye no kwipimisha kwa muganga.

• Abarwayi barashobora kwipimisha kwa muganga mbere, mugihe, cyangwa nyuma yo gutangira kuvura kanseri.

• Ibizamini byo gukurikirana birashobora gukenerwa.

Hariho uburyo butandukanye bwo kuvura abarwayi bafite lymphoma itari Hodgkin.

Ubwoko butandukanye bwo kuvura burahari kubarwayi bafite lymphoma itari Hodgkin. Bumwe mu buryo busanzwe (ubuvuzi bukoreshwa ubu), kandi bumwe burimo kugeragezwa mubigeragezo byamavuriro. Ikigeragezo kivura ni ubushakashatsi bwakozwe bugamije gufasha kunoza imiti igezweho cyangwa kubona amakuru ku buvuzi bushya ku barwayi ba kanseri. Iyo ibizamini byo kwa muganga byerekana ko ubuvuzi bushya buruta ubuvuzi busanzwe, ubuvuzi bushya bushobora kuba ubuvuzi busanzwe. Abarwayi barashobora kwifuza gutekereza kubijyanye no kwipimisha kwa muganga. Ibigeragezo bimwe na bimwe bivura abarwayi batatangiye kuvurwa.

Ku bagore batwite bafite lymphoma itari Hodgkin, ubuvuzi bwatoranijwe neza kugirango burinde umwana utaravuka. Ibyemezo byo kuvura bishingiye ku byifuzo bya nyina, icyiciro cya lymphoma itari Hodgkin, n'imyaka y'uruhinja rutaravuka. Gahunda yo kuvura irashobora guhinduka nkibimenyetso nibimenyetso, kanseri, no gutwita. Guhitamo uburyo bukwiye bwo kuvura kanseri nicyemezo kirimo cyane cyane umurwayi, umuryango, hamwe nitsinda ryita kubuzima.

Abarwayi bafite lymphoma itari Hodgkin bagomba kwivuza byateguwe nitsinda ryabatanga ubuvuzi ninzobere mu kuvura lymphoma.

Ubuvuzi buzakurikiranwa n’umuganga wa oncologue, umuganga winzobere mu kuvura kanseri, cyangwa umuhanga mu kuvura indwara z’amaraso, umuganga winzobere mu kuvura kanseri y’amaraso. Umuganga wa oncologue arashobora kukwohereza kubandi bashinzwe ubuzima bafite uburambe kandi ni abahanga mu kuvura lymphoma ikuze itari Hodgkin kandi bazobereye mu bice bimwe na bimwe by’ubuvuzi. Aba bashobora kuba barimo inzobere zikurikira:

• Neurosurgeon.

• Neurologue.

• Imirasire ya oncologue.

• Endocrinologue.

• Inzobere mu gusubiza mu buzima busanzwe.

• Abandi bahanga ba oncology.

Umuti wa lymphoma ukuze utari Hodgkin urashobora gutera ingaruka.

Kumakuru yingaruka zitangira mugihe cyo kuvura kanseri, reba urupapuro rwuruhande rwacu.

Ingaruka ziterwa no kuvura kanseri zitangira nyuma yo kuvurwa zikomeza amezi cyangwa imyaka byitwa ingaruka zitinze. Kuvura hamwe na chimiotherapie, kuvura imirasire, cyangwa guhinduranya ingirabuzimafatizo ya lymphoma itari Hodgkin bishobora kongera ibyago byo gutinda.

Ingaruka zo kuvura kanseri zishobora kuba zikubiyemo ibi bikurikira:

• Ibibazo by'umutima.

• Kutabyara (kudashobora kubyara).

• Gutakaza ubwinshi bw'amagufwa.

• Neuropathie (kwangiza imitsi itera kunanirwa cyangwa kugora kugenda).

• Kanseri ya kabiri, nka:

• Kanseri y'ibihaha.

• Kanseri y'ubwonko.

• Kanseri y'impyiko.

• Kanseri y'uruhago.

• Melanoma.

• Lymphoma ya Hodgkin.

• Indwara ya Myelodysplastic.

• Indwara ya myeloid ikaze.

Ingaruka zimwe zitinze zishobora kuvurwa cyangwa kugenzurwa. Ni ngombwa kuganira na muganga wawe ku ngaruka kuvura kanseri bishobora kukugiraho. Gukurikirana buri gihe kugirango ugenzure ingaruka zitinze ni ngombwa.

Ubwoko icyenda bwo kuvura busanzwe bukoreshwa:

Imiti ivura imirasire

Imishwarara ivura ni imiti ikoresha kanseri ikoresha ingufu nyinshi za x-imirasire cyangwa ubundi bwoko bwimirasire yica kanseri cyangwa ikabuza gukura.

Imiti ivura hanze ikoresha imashini hanze yumubiri kugirango yohereze imirasire yerekeza kumubiri hamwe na kanseri. Rimwe na rimwe, imirasire yumubiri wose itangwa mbere yo guterwa ingirangingo.

Imiti ivura imirasire ya proton ikoresha imigezi ya proton (uduce duto dufite charge nziza) kugirango yice selile. Ubu buryo bwo kuvura burashobora kugabanya imishwarara yangiza ingirabuzimafatizo hafi yikibyimba, nkumutima cyangwa ibere.

Imiti ivura imishwarara yo hanze ikoreshwa mu kuvura lymphoma ikuze itari Hodgkin, kandi irashobora no gukoreshwa nk'ubuvuzi bwa palliative kugirango igabanye ibimenyetso kandi imibereho myiza.

Ku mugore utwite ufite lymphoma itari Hodgkin, imiti ivura imirasire igomba gutangwa nyuma yo kubyara, niba bishoboka, kugirango birinde ingaruka zose ku mwana uri mu nda. Niba hakenewe kuvurwa ako kanya, umugore arashobora guhitamo gukomeza gutwita no guhabwa imiti ivura imirasire. Inkinzo ya gurşide ikoreshwa mugupfuka inda yumugore utwite kugirango ifashe kurinda umwana utaravuka imirase ishoboka.

Chimoterapi

Chimoterapi ni umuti wa kanseri ukoresha ibiyobyabwenge kugirango uhagarike imikurire ya kanseri, haba mu kwica selile cyangwa kubabuza gutandukana. Iyo chimiotherapie ifashwe numunwa cyangwa igaterwa mumitsi cyangwa imitsi, imiti yinjira mumaraso kandi irashobora kugera kanseri ya kanseri mumubiri (chimiotherapie sisitemu). Iyo chimiotherapie ishyizwe mumazi ya cerebrospinal fluid (intrathecal chimiotherapie), urugingo, cyangwa umwobo wumubiri nkinda, imiti yibasira cyane kanseri muri utwo turere (chimiotherapie yo mukarere). Imiti ya chimiotherapie ni ubuvuzi ukoresheje imiti ibiri cyangwa myinshi ya anticancer. Imiti ya Steroide irashobora kongerwamo, kugirango igabanye umuriro kandi igabanye ubudahangarwa bw'umubiri.

Sisitemu ya chimiotherapie ikoreshwa muburyo bwo kuvura lymphoma ikuze itari Hodgkin.

Chimoterapi ya intrathecal irashobora kandi gukoreshwa mukuvura lymphoma igaragara bwa mbere muri testicles cyangwa sinus (ahantu hatagaragara) ikikije izuru, ikwirakwiza lymphoma nini ya B, lymphoma ya Burkitt, lymphlastique lymphoma, na lymphoma zimwe na zimwe zikaze. Itangwa kugirango igabanye amahirwe yuko selile lymphoma izakwirakwira mu bwonko no mu ruti rw'umugongo. Ibi bita CNS prophylaxis.

Imiti ya chimiotherapie. Imiti igabanya ubukana yatewe mu mwanya wa intrathecal, niwo mwanya ufite amazi yo mu bwonko (CSF, yerekanwe mu bururu). Hariho inzira ebyiri zitandukanye zo gukora ibi. Bumwe mu buryo, bwerekanwa mu gice cyo hejuru cy’ishusho, ni ugutera imiti mu kigega cya Ommaya (ikintu kimeze nk'ikibumbano gishyirwa munsi y’umutwe mu gihe cyo kubagwa; gifata imiti uko inyura mu muyoboro muto mu bwonko ). Ubundi buryo, bwerekanwe mugice cyo hasi cyigishushanyo, ni ugutera inshinge muri CSF mugice cyo hepfo yinkingi yumugongo, nyuma yumwanya muto kumugongo wo hasi ubuze.

Iyo umugore utwite avuwe na chimiotherapie ya lymphoma itari Hodgkin, umwana utaravuka ntashobora kurindwa guhura na chimiotherapie. Uburyo bumwe na bumwe bwa chimiotherapie bushobora gutera ubumuga iyo butanzwe mugihembwe cyambere.

Reba Ibiyobyabwenge Byemewe kuri Lymphoma itari Hodgkin kubindi bisobanuro.

Immunotherapy

Immunotherapy nubuvuzi bukoresha sisitemu yumubiri yumurwayi kurwanya kanseri. Ibintu bikozwe numubiri cyangwa bikozwe muri laboratoire bikoreshwa mukuzamura, kuyobora, cyangwa kugarura umubiri kamere irinda kanseri. Immunomodulator hamwe na CAR T-selile ivura ni ubwoko bwikingira.

• Immunomodulator: Lenalidomide ni immunomodulator ikoreshwa mu kuvura lymphoma ikuze itari Hodgkin.

• CAR T-selile ivura: T selile yumurwayi (ubwoko bwimikorere yumubiri) irahinduka kuburyo izatera poroteyine zimwe na zimwe hejuru ya selile kanseri. T selile yakuwe kumurwayi kandi reseptor zidasanzwe zongerwa hejuru yazo muri laboratoire. Ingirabuzimafatizo zahinduwe zitwa chimeric antigen reseptor (CAR) T. Ingirabuzimafatizo za CAR T zikurira muri laboratoire ziha umurwayi infusion. Ingirabuzimafatizo za CAR T zigwira mu maraso y’umurwayi kandi zigatera kanseri. CAR T-selile ivura (nka axicabtagene ciloleucel cyangwa tisagenlecleucel) ikoreshwa mu kuvura lymphoma nini ya B ititabira ubuvuzi.

CAR T-selile. Ubwoko bwo kuvura aho selile ya T yumurwayi (ubwoko bwimikorere yumubiri) ihindurwa muri laboratoire kugirango ihuze ingirangingo za kanseri ikabica. Amaraso ava mumitsi mumaboko yumurwayi anyura mumiyoboro yerekeza mumashini ya aperesi (iterekanwa), ikuraho selile yera, harimo na selile T, kandi igasubiza amaraso asigaye kumurwayi. Hanyuma, gene ya reseptor idasanzwe yitwa chimeric antigen reseptor (CAR) yinjizwa muri selile T muri laboratoire. Amamiriyoni ya selile CAR T akura muri laboratoire hanyuma agahabwa umurwayi yatewe. Ingirabuzimafatizo za CAR T zishobora guhuza antigen kuri selile ya kanseri ikabica.

Reba Ibiyobyabwenge Byemewe kuri Lymphoma itari Hodgkin kubindi bisobanuro.

Ubuvuzi bugamije

Ubuvuzi bugamije ni uburyo bwo kuvura bukoresha ibiyobyabwenge cyangwa ibindi bintu kugirango umenye kandi utere kanseri yihariye ya kanseri utangiza ingirabuzimafatizo zisanzwe. Ubuvuzi bwa antibody ya Monoclonal, proteasome inhibitor therapy, hamwe na kinase inhibitor ivura ni ubwoko bwubuvuzi bugenewe gukoreshwa mu kuvura lymphoma ikuze itari Hodgkin.

Ubuvuzi bwa Monoclonal antibody nubuvuzi bwa kanseri bukoresha antibodies zakozwe muri laboratoire ziva mubwoko bumwe bwimikorere yumubiri. Iyi antibodies irashobora kumenya ibintu biri muri kanseri ya kanseri cyangwa ibintu bisanzwe bishobora gufasha kanseri gukura. Antibodiyite ifata ibintu kandi ikica selile ya kanseri, ikabuza gukura kwayo, cyangwa ikabuza gukwirakwira. Bashobora gukoreshwa bonyine cyangwa gutwara ibiyobyabwenge, uburozi, cyangwa ibikoresho bya radio bikoresha kanseri ya kanseri. Antibodiyite za Monoclonal zitangwa no gushiramo.

Ubwoko bwa antibodiyite za monoclonal zirimo:

• Rituximab, ikoreshwa mu kuvura ubwoko bwinshi bwa lymphoma itari Hodgkin.

• Obinutuzumab, ikoreshwa mu kuvura lymphoma.

• Brentuximab vedotin, irimo antibody ya monoclonal ihuza proteine ​​yitwa CD30 iboneka kuri selile zimwe na zimwe za lymphoma. Harimo kandi imiti igabanya ubukana ishobora gufasha kwica kanseri.

• Yttrium Y 90-ibritumomab tiuxetan, urugero rwa antibody ya monoclonal ya radiolabel.

Ubuvuzi bwa proteasome inhibitor buhagarika ibikorwa bya proteasomes muri selile kanseri. Proteasomes ikuraho poroteyine zitagikenewe na selile. Iyo poroteyine zifunze, poroteyine ziba mu ngirabuzimafatizo kandi zishobora gutera kanseri ya kanseri. Bortezomib ikoreshwa mu kugabanya urugero immunoglobuline M iri mu maraso nyuma yo kuvura kanseri ya lymphoplasmacytic lymphoma. Harimo kandi kwigwa kuvura lymphoma ya mantle yasubiwemo.

Ubuvuzi bwa Kinase inhibitori buhagarika poroteyine zimwe na zimwe, zishobora gufasha kurinda selile lymphoma gukura kandi zishobora kubica. Ubuvuzi bwa Kinase inhibitor burimo:

• Copanlisib, idelalisib, na duvelisib, bibuza poroteyine za P13K kandi bishobora gufasha kurinda lymphoma selile. Bakoreshwa mukuvura lymphoma ya follicular itari Hodgkin yongeye kugaruka (garuka) cyangwa itameze neza nyuma yo kuvurwa byibuze ubundi buryo bubiri.

• Ibrutinib na acalabrutinib, ubwoko bwa Bruton tyrosine kinase inhibitor therapy. Zikoreshwa mu kuvura lymphoplasmacytic lymphoma na lymphoma selile.

Venetoclax irashobora kandi gukoreshwa mu kuvura lymphoma selile. Ihagarika ibikorwa bya poroteyine yitwa B-selile lymphoma-2 (BCL-2) kandi irashobora gufasha kwica kanseri.

Reba Ibiyobyabwenge Byemewe kuri Lymphoma itari Hodgkin kubindi bisobanuro.

Plasmapheresis

Niba amaraso abaye umubyimba hamwe na poroteyine ziyongera kandi bikagira ingaruka ku kuzenguruka, plasmapheresi ikorwa kugirango ikureho plasma na proteyine ziyongera mu maraso. Muri ubu buryo, amaraso akurwa kumurwayi hanyuma akoherezwa hakoreshejwe imashini itandukanya plasma (igice cyamazi cyamaraso) na selile yamaraso. Plasma yumurwayi irimo antibodi zidakenewe kandi ntisubizwa umurwayi. Uturemangingo dusanzwe twamaraso dusubizwa mumaraso hamwe na plasma yatanzwe cyangwa gusimbuza plasma. Plasmapheresis ntabwo ibuza antibodi nshya gukora.

Gutegereza neza

Gutegereza witonze ni ugukurikiranira hafi uko umurwayi ameze atabanje kwivuza kugeza ibimenyetso cyangwa ibimenyetso bigaragara cyangwa bihindutse.

Ubuvuzi bwa antibiyotike

Ubuvuzi bwa Antibiyotike ni ubuvuzi bukoresha ibiyobyabwenge mu kuvura indwara na kanseri biterwa na bagiteri na mikorobe.

Reba Ibiyobyabwenge Byemewe kuri Lymphoma itari Hodgkin kubindi bisobanuro.

Kubaga

Kubaga birashobora gukoreshwa mugukuraho lymphoma kubarwayi bamwe na bamwe bafite lymphoma idashaka cyangwa ikaze.

Ubwoko bwo kubaga bukoreshwa bivana na lymphoma ikorwa mumubiri:

• Kwisuzumisha kwaho kubarwayi bamwe na bamwe bafite lymphhoide zifitanye isano na mucosa (MALT) lymphoma, PTLD, ninda ntoya T-selile lymphoma.

• Gutandukanya abarwayi bafite lymphoma ya marginal ya spleen.

Abarwayi bafite umutima, ibihaha, umwijima, impyiko, cyangwa pancreas transplant bakenera gufata ibiyobyabwenge kugirango bahagarike ubudahangarwa bwabo ubuzima bwabo bwose. Gukingira indwara igihe kirekire nyuma yo guterwa urugingo birashobora gutera ubwoko runaka bwa lymphoma itari Hodgkin bita lymphoproliferative disorder (PLTD).

Kubaga amara mato akenshi birakenewe kugirango hamenyekane indwara ya celiac kubantu bakuze bafite ubwoko bwa lymphoma T-selile.

Gutera ingirabuzimafatizo

Gutera ingirabuzimafatizo ni uburyo bwo gutanga urugero rwinshi rwa chimiotherapie na / cyangwa imirasire yumubiri wose hanyuma ugasimbuza ingirabuzimafatizo zangiza amaraso zangijwe no kuvura kanseri. Ingirabuzimafatizo (selile zidakuze) zivanwa mumaraso cyangwa mumagufa yumurwayi (transplant autologique) cyangwa umuterankunga (transplant allogeneic) hanyuma arakonjeshwa akabikwa. Nyuma ya chimiotherapie na / cyangwa imiti ivura imirasire irangiye, ingirabuzimafatizo zibitswe zashwanyagujwe hanyuma zisubizwa umurwayi binyuze mu gushiramo. Izi ngirabuzimafatizo zongeye gukoreshwa zikura (kandi zigarura) ingirangingo z'amaraso z'umubiri.

Gutera ingirabuzimafatizo. (Intambwe ya 1): Amaraso yakuwe mumitsi mumaboko yumuterankunga. Umurwayi cyangwa undi muntu ashobora kuba umuterankunga. Amaraso atembera mumashini ikuraho ingirabuzimafatizo. Noneho amaraso asubizwa abaterankunga binyuze mumitsi mumaboko yandi. (Intambwe ya 2): Umurwayi yakira chimiotherapie kugirango yice selile zikora amaraso. Umurwayi arashobora guhabwa imiti ivura imirasire (iterekanwa). (Intambwe ya 3): Umurwayi yakira ingirabuzimafatizo binyuze muri catheter yashyizwe mu maraso mu gituza.

Ubwoko bushya bwo kuvura burimo kugeragezwa mubigeragezo byamavuriro.

Iki gice cyincamake gisobanura imiti irimo kwigwa mubigeragezo byamavuriro. Ntishobora kuvuga ubuvuzi bushya burimo kwigwa. Amakuru yerekeye ibizamini byamavuriro araboneka kurubuga rwa NCI.

Ubuvuzi bw'inkingo

Ubuvuzi bwinkingo nubuvuzi bwa kanseri bukoresha ibintu cyangwa itsinda ryibintu kugirango bikangure sisitemu yumubiri kugirango ibone ikibyimba ikice.

Abarwayi barashobora kwifuza gutekereza kubijyanye no kwipimisha kwa muganga.

Ku barwayi bamwe, kwitabira ikizamini cyamavuriro birashobora kuba uburyo bwiza bwo kuvura. Ibigeragezo bivura biri mubikorwa byubushakashatsi bwa kanseri. Igeragezwa rya Clinical rikorwa kugirango hamenyekane niba imiti mishya ya kanseri itekanye kandi ifite akamaro cyangwa nziza kuruta ubuvuzi busanzwe.

Benshi mubuvuzi busanzwe bwa kanseri bushingiye kubigeragezo byambere byubuvuzi. Abarwayi bitabiriye kwipimisha barashobora kuvurwa bisanzwe cyangwa kuba mubambere bahawe imiti mishya.

Abarwayi bitabira ibizamini byo kwa muganga nabo bafasha kunoza uburyo kanseri izavurwa mugihe kizaza. Nubwo ibigeragezo bivura bitaganisha ku buvuzi bushya, akenshi basubiza ibibazo byingenzi kandi bigafasha gutera imbere ubushakashatsi.

Abarwayi barashobora kwipimisha kwa muganga mbere, mugihe, cyangwa nyuma yo gutangira kuvura kanseri.

Igeragezwa rimwe na rimwe ririmo abarwayi bataravurwa. Ibindi bigeragezo bipima abarwayi bafite kanseri itameze neza. Hariho kandi ibizamini byo kwa muganga bipima uburyo bushya bwo guhagarika kanseri kongera kugaruka (kugaruka) cyangwa kugabanya ingaruka zo kuvura kanseri.

Igeragezwa rya Clinical ririmo kubera mu bice byinshi by'igihugu. Amakuru yerekeye ibizamini byamavuriro ashyigikiwe na NCI urashobora kubisanga kurubuga rwa NCI. Ibizamini bya Clinical bishyigikiwe nandi mashyirahamwe murashobora kubisanga kurubuga rwa ClinicalTrials.gov.

Ibizamini byo gukurikirana birashobora gukenerwa.

Bimwe mubizamini byakozwe mugupima kanseri cyangwa kumenya icyiciro cya kanseri birashobora gusubirwamo. Ibizamini bimwe bizasubirwamo kugirango harebwe uburyo ubuvuzi bukora neza. Ibyemezo bijyanye no gukomeza, guhindura, cyangwa guhagarika ubuvuzi birashobora gushingira kubisubizo byibi bizamini.

Bimwe mubizamini bizakomeza gukorwa buri gihe nyuma yubuvuzi burangiye. Ibisubizo by'ibi bizamini birashobora kwerekana niba ubuzima bwawe bwarahindutse cyangwa niba kanseri yarongeye (garuka). Ibi bizamini rimwe na rimwe byitwa gukurikirana-ibizamini cyangwa kugenzura.

Umuti wa Indolent Non-Hodgkin Lymphoma

Kumakuru yerekeye imiti yavuzwe hepfo, reba igice cyo kuvura.

Ubuvuzi bwicyiciro cya I nubushake, icyiciro cya kabiri gikuze kitari lymphoma ya Hodgkin gishobora kubamo ibi bikurikira:

• Imiti ivura imirasire.
• Ubuvuzi bwa antibody ya monoclonal (rituximab) na / cyangwa chimiotherapie.
• Gutegereza neza.

Niba ikibyimba ari kinini cyane ku buryo kidashobora kuvurwa hakoreshejwe imiti ivura imirasire, hazakoreshwa uburyo bwo kuvura icyiciro cya II, III, cyangwa IV gikuze kitari Hodgkin lymphoma.

Kuvura ibyiciro bidahwitse, bidahuye icyiciro cya II, III, cyangwa IV lymphoma ikuze itari Hodgkin irashobora kuba ikubiyemo ibi bikurikira:

• Witondere gutegereza abarwayi badafite ibimenyetso cyangwa ibimenyetso.

• Ubuvuzi bwa antibody ya monoclonal (rituximab) hamwe na chimiotherapie cyangwa idafite.

• Kubungabunga ubuvuzi hamwe na rituximab.

• Ubuvuzi bwa antibody ya monoclonal (obinutuzumab).

• Ubuvuzi bwa PI3K (copanlisib, idelalisib, cyangwa duvelisib).

• Lenalidomide na rituximab.

• Umuti wa antibody ya radiolabel.

• Ikigeragezo cyamavuriro ya chimiotherapie ikabije cyangwa idafite imirasire yumubiri wose cyangwa imiti ya antibody ya monoclonal ya radiolabel, ikurikirwa

• autologous cyangwa allogeneic stem selile transplant.

• Igeragezwa rya chimiotherapie hamwe nubuvuzi bwinkingo.

• Ikigeragezo cyamavuriro yubwoko bushya bwa antibodiyite.

• Igeragezwa rya clinique yo kuvura imirasire irimo lymph node hafi, kubarwayi bafite icyiciro cya III.

• Ikigeragezo kivura imiti ivura imishwarara mike, kugirango igabanye ibimenyetso kandi imibereho myiza.

Ubundi buryo bwo kuvura lymphoma idafite ubushake buterwa n'ubwoko bwa lymphoma itari Hodgkin. Ubuvuzi bushobora kubamo ibi bikurikira:

• Kuri lymphoma ya follicular, kuvura birashobora kuba mubigeragezo bivura imiti mishya ya antibody ya monoclonal, uburyo bushya bwa chimiotherapie, cyangwa uruti

kwimura selile.

• Kuri lymphoma ya follicular yongeye kugaruka (garuka) cyangwa itigeze imera neza nyuma yo kuvurwa, ubuvuzi bushobora kubamo PI3K inhibitor

(copanlisib, idelalisib, cyangwa duvelisib).

• Kuri lymphoplasmacytic lymphoma, Bruton tyrosine kinase inhibitor therapy na / cyangwa plasmapheresis cyangwa proteasome inhibitor ivura (niba bikenewe

kugirango amaraso yorohewe) arakoreshwa. Ubundi buvuzi bumeze nkubukoreshwa kuri lymphoma follicular burashobora gutangwa.

• Indwara ya lymphoide yo mu gifu ifitanye isano na lymphhoide (MALT) lymphoma, ubuvuzi bwa antibiotique bwo kuvura indwara ya Helicobacter pylori butangwa mbere.

Kubibyimba bidasubiza imiti ya antibiotique, kuvura ni imiti ivura imirasire, kubaga, cyangwa rituximab hamwe na chimiotherapie cyangwa idafite.

• Kuri lymphoma idasanzwe y'amaso na lymphoma yo mu nda ya Mediterane, imiti ya antibiotique ikoreshwa mu kuvura indwara.

• Kuri lymphoma ya splenic marginal, rituximab hamwe na chimiotherapie cyangwa idafite imiti hamwe nubuvuzi bwa B-selile ikoreshwa nkubuvuzi bwambere. Niba ikibyimba kititabira kuvurwa, hashobora gukorwa splenectomy.

Umuti wa Lymphoma udakabije

Kumakuru yerekeye imiti yavuzwe hepfo, reba igice cyo kuvura.

Kuvura icyiciro cya I gikaze kandi gikaze, icyiciro cya kabiri gikuze lymphoma ikuze itari Hodgkin irashobora kuba ikubiyemo ibi bikurikira:

• Ubuvuzi bwa antibody ya monoclonal (rituximab) hamwe na chimiotherapie. Rimwe na rimwe, imiti ivura imirasire itangwa nyuma.

• Igeragezwa rya clinique yuburyo bushya bwo kuvura antibody ya monoclonal hamwe na chimiotherapie.

Kuvura ibyiciro bikaze, bidahuye nicyiciro cya II, III, cyangwa IV lymphoma ikuze itari Hodgkin irashobora kuba ikubiyemo ibi bikurikira:

• Ubuvuzi bwa antibody ya monoclonal (rituximab) hamwe na chimiotherapie.

• Ubuvuzi bwa chimiotherapie.

• Igeragezwa rya clinique ya antibody ivura monoclonal hamwe na chimiotherapie ikomatanya ikurikirwa no kuvura imirasire.

Ubundi buvuzi buterwa n'ubwoko bwa lymphoma ikaze itari Hodgkin. Ubuvuzi bushobora kubamo ibi bikurikira:

• Kuri lymphoma idasanzwe ya NK- / T-selile, imiti ivura imirasire ishobora gutangwa mbere, mugihe, cyangwa nyuma ya chimiotherapie na CNS prophylaxis.

• Kuri lymphoma ya mantle selile, antibody ya antibody ya monoclonal hamwe na chimiotherapie ikomatanya, ikurikirwa no guterwa ingirangingo. Ubuvuzi bwa antibody ya Monoclonal burashobora gutangwa nyuma yubuvuzi bwo kubungabunga (ubuvuzi butangwa nyuma yubuvuzi bwambere kugirango bufashe kanseri kutagaruka).

• Kurwara lymphoproliferative posttransplantation, kuvura imiti ikingira indwara birashobora guhagarara. Niba ibi bidakora cyangwa bidashobora gukorwa, imiti ya antibody ya monoclonal yonyine cyangwa hamwe na chimiotherapie irashobora gutangwa. Kuri kanseri itakwirakwiriye, hashobora gukoreshwa kubaga gukuraho kanseri cyangwa imiti ivura imirasire.

• Kuri lymphoma ya plasmablastique, kuvura ni nkibikoreshwa muri lymphlastique lymphoma cyangwa lymphoma ya Burkitt.

Ushaka kumenya amakuru yerekeye kuvura lymphoblastique, reba uburyo bwo kuvura Lymphoblastique Lymphoma no kumakuru yerekeye kuvura lymphoma ya Burkitt, reba uburyo bwo kuvura Lymphoma ya Burkitt.

Umuti wa Lymphoblastique Lymphoma

Kumakuru yerekeye imiti yavuzwe hepfo, reba igice cyo kuvura.

Kuvura lymphoboma ikuze irashobora kuba ikubiyemo ibi bikurikira:

• Gukomatanya imiti hamwe na CNS prophylaxis. Rimwe na rimwe, imiti ivura imirasire nayo itangwa kugirango igabanye ikibyimba kinini.

• Ubuvuzi bugamije hamwe na antibody ya monoclonal yonyine (rituximab) cyangwa ihujwe na kinase inhibitor therapy (ibrutinib).

• Igeragezwa rya clinique yo guterwa ingirabuzimafatizo nyuma yo kuvurwa bwa mbere.

Umuti wa Burkitt Lymphoma

Kumakuru yerekeye imiti yavuzwe hepfo, reba igice cyo kuvura.

Kuvura lymphoma ikuze irashobora kuba ikubiyemo ibi bikurikira:

• Gukomatanya chimiotherapie hamwe cyangwa idafite antibody ya monoclonal.

• Indwara ya CNS.

Umuti wa Lymphoma itari Hodgkin

Kumakuru yerekeye imiti yavuzwe hepfo, reba igice cyo kuvura.

Kuvura lymphoma ikuze idahwitse, isubirwamo irashobora kuba ikubiyemo ibi bikurikira:

• Chimiotherapie hamwe nibiyobyabwenge cyangwa byinshi.

• Ubuvuzi bwa antibody ya Monoclonal (rituximab cyangwa obinutuzumab).

• Lenalidomide.

• Umuti wa antibody ya radiolabel.

• Imiti ivura imishwarara nka palliative therapy kugirango igabanye ibimenyetso kandi izamure ubuzima.

• Igeragezwa rya clinique ya autologique cyangwa allogeneic stem selile transplant.

Kuvura lymphoma ikuze, isubirwamo ikuze itari Hodgkin irashobora kuba ikubiyemo ibi bikurikira:

• Chimiotherapie hamwe cyangwa idafite ingirabuzimafatizo.

• Indwara ya antibody ya Monoclonal hamwe na chimiotherapie ikomatanyije ikurikirwa na autologique stem selile transplant.

• Imiti ivura imishwarara nka palliative therapy kugirango igabanye ibimenyetso kandi izamure ubuzima.

• Umuti wa antibody ya radiolabel.

• CAR T-selile.

• Kuri lymphoma ya mantle selile, kuvura bishobora kubamo ibi bikurikira:

• Bruton tyrosine kinase inhibitor ivura.

• Lenalidomide.

• Igeragezwa rya clinique ya lenalidomide hamwe na antibody ya monoclonal.

• Ikigeragezo kivura kigereranya lenalidomide nubundi buvuzi.

• Igeragezwa rya kliniki ya proteasome inhibitor ivura (bortezomib).

• Igeragezwa rya clinique ya autologique cyangwa allogeneic stem selile transplant.

Kuvura lymphoma idahwitse igaruka nka lymphoma ikaze biterwa n'ubwoko bwa lymphoma itari Hodgkin kandi bishobora kuba bikubiyemo kuvura imirasire nk'ubuvuzi bwa palliative bwo kugabanya ibimenyetso no kuzamura imibereho. Kuvura lymphoma ikaze igaruka nka lymphoma idahwitse irashobora kuba irimo chimiotherapie.

Kuvura Lymphoma itari Hodgkin mugihe cyo gutwita

Muri iki gice

• Indolent Non-Hodgkin Lymphoma Mugihe cyo Gutwita

• Lymphoma Yibabaza Atari Hodgkin Mugihe cyo Gutwita

Kumakuru yerekeye imiti yavuzwe hepfo, reba igice cyo kuvura.

Indolent Non-Hodgkin Lymphoma Mugihe cyo Gutwita

Abagore bafite lymphoma idafite ubushake (gukura-buhoro) itari Hodgkin mugihe batwite barashobora kuvurwa bategereje neza kugeza nyuma yo kubyara. (Reba uburyo bwo kuvura Indolent Non-Hodgkin Lymphoma kubindi bisobanuro.)

Lymphoma Yibabaza Atari Hodgkin Mugihe cyo Gutwita

Kuvura lymphoma ikaze itari Hodgkin mugihe utwite irashobora kuba ikubiyemo ibi bikurikira:

• Umuti utangwa ako kanya ukurikije ubwoko bwa lymphoma itari Hodgkin kugirango wongere amahirwe yo kubaho kwa nyina. Umuti urashobora gushiramo imiti ya chimiotherapie na rituximab.

• Kubyara hakiri kare hakurikiraho kuvurwa hashingiwe ku bwoko bwa lymphoma itari Hodgkin.

• Niba mu gihembwe cya mbere cyo gutwita, abaganga ba oncologue barashobora gutanga inama yo kurangiza gutwita kugirango ubuvuzi butangire. Kuvura biterwa n'ubwoko bwa lymphoma itari Hodgkin.

Kwiga Byinshi Kubantu Bakuze Non-Hodgkin Lymphoma

Ushaka amakuru menshi yikigo cyigihugu cya kanseri kubyerekeye lymphoma ikuze itari Hodgkin, reba ibi bikurikira:

• Urupapuro rwitangiriro rwa Hodgkin

• Ibiyobyabwenge Byemewe kuri Lymphoma itari Hodgkin

• Intego zo kuvura Kanseri

• Immunotherapy yo kuvura Kanseri

Kumakuru rusange ya kanseri nibindi bikoresho biva mu kigo cyigihugu cya kanseri, reba ibi bikurikira:

• Ibyerekeye Kanseri

• Gutegura

• Chimiotherapie nawe: Inkunga kubantu barwaye Kanseri

• Ubuvuzi bwimirasire nawe: Inkunga kubantu barwaye Kanseri

• Guhangana na Kanseri

• Ibibazo byo Kubaza Muganga wawe kuri Kanseri

• Abacitse ku icumu n'abarezi