About-cancer/treatment/clinical-trials/thymoma-thymic-carcinoma
Igeragezwa rya Clinical yo kuvura Thymoma na Thymic Carcinoma
Ikigeragezo 1-12 cya 12
Carboplatin na Paclitaxel hamwe na Ramucirumab cyangwa idafite kuvura abarwayi bafite kanseri yateye imbere, isubirwamo, cyangwa Metastatike Thymic Kanseri idashobora gukurwaho no kubagwa
Igeragezwa ryicyiciro cya kabiri cyiga uburyo karboplatine na paclitaxel hamwe na ramucirumab cyangwa idafite akazi ka ramucirumab mukuvura abarwayi ba kanseri ya thymic yakwirakwiriye mubice byegereye cyangwa lymph node (byateye imbere), byagarutse (byongeye), bikwirakwira ahandi hantu muri umubiri (metastatike) cyangwa ntishobora gukurwaho no kubagwa. Ibiyobyabwenge bikoreshwa muri chimiotherapie, nka karboplatine na paclitaxel, bikora muburyo butandukanye bwo guhagarika imikurire ya selile yibibyimba, haba mu kwica selile, kubabuza gutandukana, cyangwa kubabuza gukwirakwira. Antibodiyite za Monoclonal, nka ramucirumab, zishobora kubangamira ubushobozi bwingirabuzimafatizo zo gukura no gukwirakwira. Kugeza ubu ntiharamenyekana niba gutanga karboplatine na paclitaxel hamwe na ramucirumab cyangwa bidafite akamaro bizakora neza mu kuvura abarwayi ba kanseri ya thimic.
Aho uherereye: 254
Inyigo ya XmAb®20717 mubintu hamwe na Byatoranijwe Bikomeye Byibibyimba
Iki nicyiciro cya 1, igipimo cyinshi, ubushakashatsi bwiyongera bwa dose escalation kugirango busobanure MTD / RD nuburyo bwa XmAb20717, gusobanura umutekano no kwihanganirana, gusuzuma PK na immunogenicite, no gusuzuma mbere na mbere ibikorwa byo kurwanya ibibyimba bya XmAb20717 mubisomo byatoranijwe ibibyimba bikomeye.
Aho uherereye: ahantu 15
Nivolumab na Vorolanib mu kuvura abarwayi bafite kanseri y'ibihaha itari mito na kanseri ya Thoracic.
Iki cyiciro cya I / II cyiga ku ngaruka n'ingaruka nziza ya vorolanib iyo itanzwe ifatanije na nivolumab mu kuvura abarwayi bafite kanseri y'ibihaha itari ntoya hamwe n'ibibyimba bya thoracic bititabira kwivuza (retractory). Immunotherapy hamwe na antibodiyite za monoclonal, nka nivolumab, irashobora gufasha umubiri wumubiri gutera kanseri, kandi irashobora kubangamira ubushobozi bwingirabuzimafatizo zikura no gukwirakwira. Vorolanib irashobora guhagarika imikurire ya selile yibibyimba ihagarika imisemburo ikenewe kugirango imikurire ikure. Gutanga nivolumab na vorolanib birashobora gukora neza mukuvura abarwayi bafite kanseri y'ibihaha itari ntoya hamwe n'ibibyimba bya thoracic.
Aho uherereye: ahantu 7
Kwiga SO-C101 na SO-C101 muguhuza na Pembro mubarwayi bakuze bafite ibibyimba bigezweho / Metastatic Solid Tumors
Multicenter ifungura-label icyiciro 1 / 1b ubushakashatsi kugirango harebwe umutekano nibikorwa byambere bya SO-C101 nka monotherapy kandi ifatanije na pembrolizumab kubarwayi bafite ibibyimba byatoranijwe byateye imbere / metastatike.
Aho uherereye: ahantu 2
Isesengura ryihuse nigisubizo cyo gusuzuma imiti igabanya ubukana bwa Neoplastique mu Bibyimba Bidasanzwe (KANSERI NTIBISANZWE) Ikigeragezo: NTIBISANZWE 1 Nilotinib na Paclitaxel
Amavu n'amavuko: Abantu bafite kanseri zidasanzwe akenshi bafite uburyo buke bwo kuvura. Ibinyabuzima bya kanseri idasanzwe ntabwo byumvikana neza. Abashakashatsi bifuza kubona uburyo bwiza bwo kuvura kanseri. Bashaka gupima ibiyobyabwenge 2, byafashwe ukwe, bifasha abantu barwaye kanseri idasanzwe. Bashaka kureba niba iyi miti hamwe ishobora gutuma kanseri zidasanzwe zigabanuka cyangwa guhagarika gukura. Intego: Kumenya niba nilotinib na paclitaxel bizagirira akamaro abantu barwaye kanseri idasanzwe. Abemerewe: Abantu bafite imyaka 18 nayirenga bafite kanseri idasanzwe, yateye imbere yateye imbere nyuma yo kuvurwa bisanzwe, cyangwa kubwo kutavura neza. Igishushanyo: Abitabiriye amahugurwa bazerekanwa n'amateka y'ubuvuzi n'ikizamini cy'umubiri. Bazokwipimisha amaraso ninkari. Bazokwipimisha inda nibikenewe. Bazagira electrocardiogram yo gusuzuma imitima yabo. Bazaba bafite amashusho yo gupima ibibyimba byabo. Abitabiriye amahugurwa bazasubiramo ibizamini byo gusuzuma mugihe cyo kwiga. Abitabiriye amahugurwa bazahabwa nilotinib na paclitaxel. Ibiyobyabwenge bitangwa muminsi 28. Nilotinib ni capsule ifatwa numunwa kabiri kumunsi. Paclitaxel izahabwa imitsi n'umurongo wa peripheri cyangwa umurongo wo hagati rimwe mucyumweru ibyumweru 3 byambere bya buri cyiciro. Abitabiriye amahugurwa bazakomeza kwandika imiti. Bazakurikirana igihe bafashe ibiyobyabwenge byo kwiga n'ingaruka zose bashobora kugira. Abitabiriye amahugurwa barashobora kugira ibibyimba bidasanzwe. Abitabiriye amahugurwa barashobora kuguma ku bushakashatsi kugeza igihe indwara yabo izaba mbi cyangwa bakagira ingaruka zitihanganirwa. Abitabiriye amahugurwa bazajya bakurikirana terefone nyuma yiminsi 30 nyuma yo gufata igipimo cya nyuma cyibiyobyabwenge. Abitabiriye amahugurwa bazahabwa nilotinib na paclitaxel. Ibiyobyabwenge bitangwa muminsi 28. Nilotinib ni capsule ifatwa numunwa kabiri kumunsi. Paclitaxel izahabwa imitsi n'umurongo wa peripheri cyangwa umurongo wo hagati rimwe mucyumweru ibyumweru 3 byambere bya buri cyiciro. Abitabiriye amahugurwa bazakomeza kwandika imiti. Bazakurikirana igihe bafashe ibiyobyabwenge byo kwiga n'ingaruka zose bashobora kugira. Abitabiriye amahugurwa barashobora kugira ibibyimba bidasanzwe. Abitabiriye amahugurwa barashobora kuguma ku bushakashatsi kugeza igihe indwara yabo izaba mbi cyangwa bakagira ingaruka zitihanganirwa. Abitabiriye amahugurwa bazajya bakurikirana terefone nyuma yiminsi 30 nyuma yo gufata igipimo cya nyuma cyibiyobyabwenge. Abitabiriye amahugurwa bazahabwa nilotinib na paclitaxel. Ibiyobyabwenge bitangwa muminsi 28. Nilotinib ni capsule ifatwa numunwa kabiri kumunsi. Paclitaxel izahabwa imitsi n'umurongo wa peripheri cyangwa umurongo wo hagati rimwe mucyumweru ibyumweru 3 byambere bya buri cyiciro. Abitabiriye amahugurwa bazakomeza kwandika imiti. Bazakurikirana igihe bafashe ibiyobyabwenge byo kwiga n'ingaruka zose bashobora kugira. Abitabiriye amahugurwa barashobora kugira ibibyimba bidasanzwe. Abitabiriye amahugurwa barashobora kuguma ku bushakashatsi kugeza igihe indwara yabo izaba mbi cyangwa bakagira ingaruka zitihanganirwa. Abitabiriye amahugurwa bazajya bakurikirana terefone nyuma yiminsi 30 nyuma yo gufata igipimo cya nyuma cyibiyobyabwenge. Paclitaxel izahabwa imitsi n'umurongo wa peripheri cyangwa umurongo wo hagati rimwe mucyumweru ibyumweru 3 byambere bya buri cyiciro. Abitabiriye amahugurwa bazakomeza kwandika imiti. Bazakurikirana igihe bafashe ibiyobyabwenge byo kwiga n'ingaruka zose bashobora kugira. Abitabiriye amahugurwa barashobora kugira ibibyimba bidasanzwe. Abitabiriye amahugurwa barashobora kuguma ku bushakashatsi kugeza igihe indwara yabo izaba mbi cyangwa bakagira ingaruka zitihanganirwa. Abitabiriye amahugurwa bazajya bakurikirana terefone nyuma yiminsi 30 nyuma yo gufata igipimo cya nyuma cyibiyobyabwenge. Paclitaxel izahabwa imitsi n'umurongo wa peripheri cyangwa umurongo wo hagati rimwe mucyumweru ibyumweru 3 byambere bya buri cyiciro. Abitabiriye amahugurwa bazakomeza kwandika imiti. Bazakurikirana igihe bafashe ibiyobyabwenge byo kwiga n'ingaruka zose bashobora kugira. Abitabiriye amahugurwa barashobora kugira ibibyimba bidasanzwe. Abitabiriye amahugurwa barashobora kuguma ku bushakashatsi kugeza igihe indwara yabo izaba mbi cyangwa bakagira ingaruka zitihanganirwa. Abitabiriye amahugurwa bazajya bakurikirana terefone nyuma yiminsi 30 nyuma yo gufata igipimo cya nyuma cyibiyobyabwenge.
Aho biherereye: Ikigo cyigihugu cyita ku buzima Clinical Centre, Bethesda, Maryland
Pembrolizumab na Sunitinib Malate mukuvura abitabiriye hamwe na Kanseri ya Thymic Metastatike cyangwa idashobora gukemurwa
Iki cyiciro cya kabiri cyikigereranyo cyiga uburyo pembrolizumab na sunitinib malate ikora neza mukuvura abitabiriye kanseri ya thimic yakwirakwiriye ahandi mu mubiri cyangwa idashobora gukurwaho no kubagwa kandi ntibitabira kwivuza. Antibodiyite za Monoclonal, nka pembrolizumab, zishobora kubangamira ubushobozi bwingirabuzimafatizo zo gukura no gukwirakwira. Sunitinib malate irashobora guhagarika imikurire ya selile yibibyimba ihagarika zimwe mumisemburo ikenewe kugirango imikurire ikure. Gutanga pembrolizumab na sunitinib malate birashobora gukora neza mukuvura kanseri ya thymic.
Aho biherereye: Ikigo cya Leta ya Ohio muri Leta Yose ya Kanseri, Columbus, Ohio
Pembrolizumab mu Kuvura Abitabiriye Indwara ya Thymoma cyangwa Kanseri ya Thymic
Iki cyiciro cya I ikigeragezo cyiga ku ngaruka n'ingaruka nziza za pembrolizumab mu kuvura abitabiriye kanseri ya thymoma cyangwa thymic idashobora gukurwaho no kubagwa. Immunotherapy hamwe na antibodiyite za monoclonal, nka pembrolizumab, irashobora gufasha umubiri wumubiri gutera kanseri, kandi irashobora kubangamira ubushobozi bwingirabuzimafatizo zikura no gukwirakwira.
Aho uherereye: MD Anderson Centre ya Kanseri, Houston, Texas
Selinexor mu Kuvura Abitabiriye hamwe na Thymic Epithelial Tumor
Iki cyiciro cya II ikigeragezo cyiga uburyo selinexor ikora neza mukuvura abitabiriye ikibyimba cya thymic epithelial ikwirakwira ahandi hantu mumubiri. Selinexor irashobora guhagarika imikurire ya selile yibibyimba ihagarika proteine zimwe na zimwe zikenewe kugirango imikurire ikure.
Aho uherereye: ahantu 2
Bintrafusp Alfa (M7824) mubintu hamwe na Thymoma na Thymic Carcinoma
Amavu n'amavuko: Thymoma na thymic carcinoma ni indwara za thymus. Chimiotherapie ishingiye kuri platine nubuvuzi busanzwe bwizi ndwara. Ariko akenshi, indwara igaruka nyuma yo kuvurwa. Abashakashatsi bifuza kureba niba ibiyobyabwenge bishya bishobora gufasha. Intego: Kureba niba bintrafusp alfa (M7824) ari uburyo bwiza bwo kuvura kanseri ya thymoma na thymic. Abemerewe: Abantu bafite imyaka 18 nayirenga bafite kanseri ya thymoma cyangwa thymic nindwara zabo bagarutse cyangwa bateye imbere nyuma yo kuvurwa byibuze gahunda imwe yo kuvura imiti ya platine irimo platine, cyangwa banze kuvura bisanzwe Igishushanyo mbonera: Abitabiriye amahugurwa bazasuzumwa na protocole itandukanye. Amateka yabo yubuvuzi, ubuvuzi, nubuvuzi bizasubirwamo. Bazagira ibibyimba biopsy niba badafite icyitegererezo. Abitabiriye amahugurwa bazabona imiti yo kwiga rimwe mubyumweru 2 nkumuvuduko wamaraso. Kubwibyo, umuyoboro muto wa plastike ushyirwa mumitsi. Mugihe cyubushakashatsi, abitabiriye amahugurwa bazakurikira ibi bikurikira: Isuzuma ryubuvuzi Isuzuma ryumubiri Gusuzuma ibimenyetso byabo nubushobozi bwabo bwo gukora ibikorwa byabo bisanzwe Amaraso namaraso yinkari Gusuzuma imitsi yibibero (ukoresheje MRI) Isuzuma ryibibyimba (ukoresheje MRI cyangwa CT) Ibizamini byimikorere yumutima nibihaha Isuzuma rya glande ya Thyroid gusuzuma uruhu. Abitabiriye amahugurwa barashobora kugira ibibyimba biopsies. Amwe mumaraso yabo hamwe na biopsy ntangarugero bizakoreshwa mugupima gene. Abitabiriye amahugurwa barashobora gufata imiti yo kwiga kugeza igihe indwara yabo izaba mbi cyangwa ntibashobora kwihanganira kwivuza. Abitabiriye amahugurwa bazakurikiranwa nyuma y'ibyumweru 2 na 6 nyuma yo guhagarika kwivuza. Noneho bazagira igihe kirekire cyo gukurikirana buri mezi 3. Ibi birashobora kubamo amashusho yerekana amashusho. Gusura birashobora gukorwa kuri terefone, hamwe na scan (niba bikenewe) bikorerwa kwa muganga. Aho uherereye:
Abexinostat na Pembrolizumab mukuvura abarwayi hamwe na MSI-Yisumbuye Yateye imbere cyangwa Ibibyimba bikomeye bya Metastatike
Iki cyiciro cya I ikigeragezo cyiga urugero rwiza ningaruka za abexinostat nuburyo ikorana neza hamwe hamwe na pembrolizumab mukuvura abarwayi bafite microsatellite ihungabana (MSI) ibibyimba bikomeye byakwirakwiriye mubice bya hafi cyangwa lymph node (byateye imbere) mu mubiri (metastatike). Abexinostat irashobora guhagarika imikurire ya selile yibibyimba ihagarika imisemburo ikenewe kugirango imikurire ikure. Immunotherapy hamwe na antibodiyite za monoclonal, nka pembrolizumab, irashobora gufasha umubiri wumubiri gutera kanseri, kandi irashobora kubangamira ubushobozi bwingirabuzimafatizo zikura no gukwirakwira. Gutanga abexinostat na pembrolizumab birashobora gukora neza mukuvura abarwayi bafite ibibyimba bikomeye.
Aho uherereye: Ikigo cyubuvuzi cya UCSF-Umusozi wa Siyoni, San Francisco, California
Umunwa TrkA Inhibitor VMD-928 yo kuvura ibibyimba bikuze bikuze cyangwa Lymphoma
Ubu ni multicenter, ifungura-label, Icyiciro cya 1 ubushakashatsi bwakozwe kumanwa VMD-928 mumasomo akuze afite ibibyimba bikomeye cyangwa lymphoma yateye imbere cyangwa idakira imiti ihari kandi idafite ubuvuzi busanzwe cyangwa buhari bwo kuvura buhari.
Aho uherereye: Umujyi w'amizero Ikigo cya Kanseri Cyuzuye, Duarte, California
Inyigisho ya Pilote yo gukora iperereza kubikorwa byumutekano nubuvuzi bwa Avelumab (MSB0010718C) muri Thymoma na Thymic Carcinoma Nyuma yiterambere kuri Chimoterapi ishingiye kuri platine.
Amavu n'amavuko: Thymoma na thymic carcinoma ni kanseri ikomoka muri glande ya thymus. Chimiotherapie ishingiye kuri platine nubuvuzi busanzwe kuri bo. Ariko ntibisanzwe, indwara iragaruka kandi abantu bakeneye ubuvuzi bwinshi kugirango kanseri idakura. Umuti Avelumab ushobora gufasha sisitemu yumubiri kurwanya kanseri. Intego: Gupima niba avelumab ifite umutekano kandi yihanganirwa neza, kandi ifite akamaro mukuvura thymoma yongeye kugaruka cyangwa yangiritse na kanseri ya thymic. Abemerewe: Abantu bafite imyaka 18 nayirenga bafite thymoma cyangwa thymic carcinoma yagarutse cyangwa yateye imbere nyuma ya platine irimo chimiotherapie Igishushanyo: Abitabiriye amahugurwa bazasuzumwa na: - Amaraso, inkari, hamwe n ibizamini byumutima - Scan: Baryamye mumashini ifotora umubiri. - Ikizamini cyumubiri - Amateka yubuvuzi - Biopsy: urushinge rukuraho igice cyikibyimba. Ingero zirashobora kuva muburyo bwabanje, nubwo ari byiza gukorerwa biopsy nshya. Abitabiriye amahugurwa bazavurwa mubyumweru 2. Bazakomeza kugeza igihe ingaruka zidashobora kwihanganira cyangwa indwara zabo zikaba mbi. Gusura mugihe gikurikira ingingo zisabwa kuri protocole. Abarwayi bitabira kwivuza cyangwa bafite umutekano urambye nyuma yiburiburi amezi 12 yubuvuzi barashobora gukorerwa dose de-escalation kugirango bakomeze kwivuza. - Buri byumweru 2: Abitabiriye amahugurwa bazabona avelumab batewe mumitsi (IV). Bazabona diphenhydramine (benadryl) na acetaminofeni (tylenol) kumunwa cyangwa IV mbere yo kwakira avelumab kugirango bagabanye amahirwe yo kugira reaction kuri avelumab. Bazagira amaraso, inkari, nibizamini byumutima buri gihe. - Inzinguzingo ya 4 na 7, hanyuma buri byumweru 6: Hazakorwa scan kugirango harebwe kugabanuka cyangwa gukura kwikibyimba. - Icyiciro cya 4: Abitabiriye amahugurwa bazahabwa amahirwe yo gukorerwa biopsy. - Ibyumweru 2-4 nyuma yo guhagarika kwivuza: Amaraso, inkari, nibizamini byumutima bizakorwa. Abitabiriye amahugurwa barashobora gukorerwa scan. - Ibyumweru 10 nyuma yo guhagarika imiti: Amaraso, inkari, hamwe no gupima umutima. - Amezi agera kuri 6 nyuma yo guhagarika kwivuza, hanyuma buri mezi 3: Abitabiriye amahugurwa bazagira scan kandi barashobora kwemerera kwipimisha genetike kumaraso yabo hamwe nuduce.
Aho biherereye: Ikigo cyigihugu cyita ku buzima Clinical Centre, Bethesda, Maryland
Emera igitekerezo auto-refresher