Ibyerekeye-kanseri / kuvura / ivuriro-ibigeragezo / indwara / kaposi-sarcoma / kuvura
Kuvura Ibizamini bya Clinical kuri Kaposi Sarcoma
Igeragezwa rya Clinical ni ubushakashatsi bwubushakashatsi burimo abantu. Ibizamini byamavuriro kururu rutonde ni ibya Kaposi sarcoma. Ibigeragezo byose kurutonde bishyigikiwe na NCI.
Amakuru yibanze ya NCI kubyerekeye ibizamini byamavuriro asobanura ubwoko nicyiciro cyibigeragezo nuburyo bikorwa. Igeragezwa rya Clinical rireba uburyo bushya bwo kwirinda, gutahura, cyangwa kuvura indwara. Urashobora gushaka gutekereza kubijyanye no kwitabira ikizamini cyamavuriro. Vugana na muganga wawe kugirango agufashe guhitamo niba umwe akubereye.
Ikigeragezo 1-7 cya 7
Nivolumab na Ipilimumab mu kuvura abarwayi banduye virusi itera sida Yongeye kwisubiraho cyangwa yangiritse ya Classic Hodgkin Lymphoma cyangwa Ibibyimba bikomeye Bipima cyangwa bidashobora gukurwaho no kubagwa
Iki cyiciro cya I cyigeragezo cyiga ku ngaruka n’igipimo cyiza cya nivolumab iyo gitanzwe na ipilimumab mu kuvura abarwayi bafite virusi itera immunodeficiency (virusi itera SIDA) ifitanye isano na lymphoma ya kera ya Hodgkin yagarutse nyuma yigihe runaka cyo gutera imbere cyangwa kutitabira kwivuza, cyangwa ibibyimba bikomeye ibyo yakwirakwiriye ahandi mu mubiri cyangwa ntishobora gukurwaho no kubagwa. Immunotherapy hamwe na antibodiyite za monoclonal, nka ipilimumab na nivolumab, birashobora gufasha umubiri wumubiri kwibasira kanseri, kandi bishobora kubangamira ubushobozi bwingirabuzimafatizo yibibyimba gukura no gukwirakwira. Ipilimumab ni antibody ikora kurwanya molekile yitwa cytotoxic T-lymphocyte antigen 4 (CTLA-4). CTLA-4 igenzura igice cya sisitemu yumubiri wawe uyifunga. Nivolumab ni ubwoko bwa antibody yihariye ku rupfu rwabantu rwateguwe 1 (PD-1), poroteyine ishinzwe gusenya ingirabuzimafatizo. Guha ipilimumab hamwe na nivolumab birashobora gukora neza mukuvura abarwayi ba virusi itera sida ya Hodgkin ya lymphoma cyangwa ibibyimba bikomeye ugereranije na ipilimumab na nivolumab yonyine.
Aho uherereye: ahantu 28
Nelfinavir Mesylate mukuvura abarwayi hamwe na Kaposi Sarcoma
Iki cyiciro cya kabiri cyikigereranyo cyiga uburyo nelfinavir mesylate ikora neza mukuvura abarwayi barwaye Kaposi sarcoma. Nelfinavir mesylate irashobora guhagarika imikurire ya selile yibibyimba ihagarika zimwe mumisemburo ikenewe kugirango imikurire ikure.
Aho uherereye: ahantu 11
sEphB4-HSA mu kuvura abarwayi hamwe na Kaposi Sarcoma
Iki cyiciro cya II cyigeragezwa cyiga recombinant EphB4-HSA fusion protein (sEphB4-HSA) mukuvura abarwayi barwaye Kaposi sarcoma. Recombinant EphB4-HSA poroteyine irashobora guhagarika imikurire yimitsi itanga amaraso kuri kanseri, kandi irashobora no kubuza selile kanseri gukura.
Aho uherereye: ahantu 10
Pembrolizumab mu kuvura abarwayi banduye virusi itera sida kandi yongeye kwisubiraho, yanga, cyangwa ikwirakwizwa na Neoplasme mbi.
Iki cyiciro cya I cyigeragezo cyiga ku ngaruka ziterwa na pembrolizumab mu kuvura abarwayi bafite virusi ikingira indwara (virusi itera SIDA) na neoplasme mbi yagarutse (isubiramo), ntibitabira kwivuza (retractory), cyangwa bakwirakwije ahantu hanini mu mubiri (ikwirakwizwa). Antibodiyite za Monoclonal, nka pembrolizumab, zishobora guhagarika ikibyimba cyangwa kanseri mu buryo butandukanye yibasira selile zimwe. Irashobora kandi gufasha sisitemu yumubiri kwica selile.
Aho uherereye: ahantu 10
Intra-lesional Nivolumab mukuvura abarwayi hamwe na Cutaneous Kaposi Sarcoma
Iki cyiciro cya I ikigeragezo cyiga ku ngaruka za nivolumab yatewe mu buryo butaziguye no kureba uburyo ikora neza mu kuvura abarwayi bafite kanseri ya Kaposi sarcoma. Immunotherapy hamwe na antibodiyite za monoclonal, nka nivolumab, irashobora gufasha umubiri wumubiri gutera kanseri, kandi irashobora kubangamira ubushobozi bwingirabuzimafatizo zikura no gukwirakwira.
Aho uherereye: ahantu 2
Amateka ya KSHV Indwara ya Cytokine (KICS)
Amavu n'amavuko: - Indwara ya KSHV inflammatory cytokine (KICS) n'indwara imaze kumenyekana iterwa na Kaposi sarcoma ifitanye isano na herpesvirus (KSHV). Iyi virusi irashobora gutera kanseri. Abantu bafite KICS barashobora kugira ibimenyetso bikomeye. Harimo umuriro, kugabanuka, hamwe n'amazi mumaguru cyangwa munda. Abantu bafite KICS nabo bashobora guhura nizindi kanseri zifitanye isano na KSHV. Izi kanseri zirimo Kaposi sarcoma na lymphoma. Kubera ko KICS ari indwara imaze kumenyekana, hakenewe amakuru menshi yukuntu iyo ndwara ikora nibishobora gukorwa kugirango tuyivure. Intego: - Gukusanya amakuru yubuvuzi nubuvuzi kubantu barwaye syndrome ya KSHV. Abemerewe: - Abantu byibuze bafite imyaka 18 y'amavuko bafite virusi ya Kaposi sarcoma herpes nibimenyetso bisa nibiterwa na KICS. Igishushanyo: - Abitabiriye amahugurwa bazajya basurwa buri gihe. Gahunda izagenwa nabashakashatsi. - Abitabiriye amahugurwa bazatanga amateka yuzuye yubuvuzi kandi bafite ikizamini cyuzuye cyumubiri. Amaraso hamwe ninkari bizakusanywa. - Abantu bafite KICS bakeneye ubuvuzi barashobora kubona uburyo bushya bwo kuvura. Ubu buvuzi bushobora kuba bukubiyemo imiti igabanya ubukana n’imiti ya chimiotherapie, bitewe n'imiterere y'indwara. - Abitabiriye amahugurwa bazagira amashusho yerekana amashusho, nk'igituza x-imirasire hamwe na tomografiya yabazwe, kugira ngo bige ibibyimba. - Amagufa yo mu magufa na lymph node biopsies arashobora gukorwa kugirango akusanyirize hamwe ingero zo kwiga. - Abitabiriye amahugurwa bafite Kaposi sarcoma bazaba bafite amafoto yafashwe. - Abantu bafite KICS bakeneye ubuvuzi barashobora kubona uburyo bushya bwo kuvura. Ubu buvuzi bushobora kuba bukubiyemo imiti igabanya ubukana n’imiti ya chimiotherapie, bitewe n'imiterere y'indwara. - Abitabiriye amahugurwa bazagira amashusho yerekana amashusho, nk'igituza x-imirasire hamwe na tomografiya yabazwe, kugira ngo bige ibibyimba. - Amagufa yo mu magufa na lymph node biopsies arashobora gukorwa kugirango akusanyirize hamwe ingero zo kwiga. - Abitabiriye amahugurwa bafite Kaposi sarcoma bazaba bafite amafoto yafashwe. - Abantu bafite KICS bakeneye ubuvuzi barashobora kubona uburyo bushya bwo kuvura. Ubu buvuzi bushobora kuba bukubiyemo imiti igabanya ubukana n’imiti ya chimiotherapie, bitewe n'imiterere y'indwara. - Abitabiriye amahugurwa bazagira amashusho yerekana amashusho, nk'igituza x-imirasire hamwe na tomografiya yabazwe, kugira ngo bige ibibyimba. - Amagufa yo mu magufa na lymph node biopsies arashobora gukorwa kugirango akusanyirize hamwe ingero zo kwiga. - Abitabiriye amahugurwa bafite Kaposi sarcoma bazaba bafite amafoto yafashwe. - Amagufa yo mu magufa na lymph node biopsies arashobora gukorwa kugirango akusanyirize hamwe ingero zo kwiga. - Abitabiriye amahugurwa bafite Kaposi sarcoma bazaba bafite amafoto yafashwe. - Amagufa yo mu magufa na lymph node biopsies arashobora gukorwa kugirango akusanyirize hamwe ingero zo kwiga. - Abitabiriye amahugurwa bafite Kaposi sarcoma bazaba bafite amafoto yafashwe.
Aho uherereye: ahantu 2
Pomalidomide muguhuza na Liposomal Doxorubicin mubantu bafite Kaposi Sarcoma yateye imbere cyangwa yanga
Amavu n'amavuko: Kaposi sarcoma (KS) ni kanseri ikunze kugaragara ku bantu banduye virusi itera SIDA. Itera ibikomere. Ubusanzwe biri kuruhu ariko rimwe na rimwe bikagira lymph node, ibihaha, na gastrointestinal tract. Abashakashatsi batekereza ko guhuza ibiyobyabwenge bishobora gufasha kuvura KS. Intego: Kugerageza guhuza imiti irwanya kanseri pomalidomide (CC-4047) na liposomal doxorubicin (Doxil) mubantu bafite KS. Abemerewe: Abantu bafite imyaka 18 nayirenga bafite Igishushanyo cya KS: Abitabiriye amahugurwa bazasuzumwa hamwe: Amateka yubuvuzi Ibibazo Ikibazo cyumubiri Amaraso, inkari, hamwe n ibizamini byumutima Chest X-ray Biopsy: Urugero ruto rwa tissue rwakuwe mubikomere bya KS. Ibishoboka CT scan Ikizamini gishoboka cyibihaha cyangwa inzira ya gastrointestinal hamwe na endoscope: Igikoresho cyoroshye gisuzuma imbere yumubiri. Abitabiriye amahugurwa bazafata ibiyobyabwenge mu byumweru 4. Bazanyura Doxil banyuze kuri IV kumunsi wa 1 wa buri cyiciro. Bazafata ibinini bya CC-4047 kumunwa buri munsi mubyumweru 3 byambere bya buri cyiciro. Abitabiriye amahugurwa bazasurwa cyane: Mbere yo gutangira kwivuza Gutangira buri cyiciro Umunsi wa 15 wikizamini cya mbere Gusura harimo gusubiramo ibizamini byo gusuzuma kandi: Amaraso menshi ashushanya Amafoto y ibikomere Abitabiriye amahugurwa bazakomeza kwandika ibiyobyabwenge. Abitabiriye amahugurwa bazafata aspirine cyangwa indi miti kugirango birinde amaraso. Abitabiriye virusi itera sida bazagira imiti igabanya ubukana bwa virusi. Bamwe mubitabiriye amahugurwa bazagira PET scan. Abitabiriye amahugurwa bazakomeza kwivuza igihe cyose babyihanganiye kandi KS yabo igatera imbere. Nyuma yo kuvurwa, bazasurwa inshuro nyinshi kubakurikirana kugeza kumyaka 5 ... Mbere yo gutangira kwivuza Gutangira buri cyiciro Umunsi wa 15 wikizamini cya mbere Gusura harimo gusubiramo ibizamini byo gusuzuma kandi: Amaraso menshi ashushanya Amafoto y ibikomere Abitabiriye amahugurwa bazakomeza kwandika ibiyobyabwenge. Abitabiriye amahugurwa bazafata aspirine cyangwa indi miti kugirango birinde amaraso. Abitabiriye virusi itera sida bazagira imiti igabanya ubukana bwa virusi. Bamwe mubitabiriye amahugurwa bazagira PET scan. Abitabiriye amahugurwa bazakomeza kwivuza igihe cyose babyihanganiye kandi KS yabo igatera imbere. Nyuma yo kuvurwa, bazasurwa inshuro nyinshi kubakurikirana kugeza kumyaka 5 ... Mbere yo gutangira kwivuza Gutangira buri cyiciro Umunsi wa 15 wikizamini cya mbere Gusura harimo gusubiramo ibizamini byo gusuzuma kandi: Amaraso menshi ashushanya Amafoto y ibikomere Abitabiriye amahugurwa bazakomeza kwandika ibiyobyabwenge. Abitabiriye amahugurwa bazafata aspirine cyangwa indi miti kugirango birinde amaraso. Abitabiriye virusi itera sida bazagira imiti igabanya ubukana bwa virusi. Bamwe mubitabiriye amahugurwa bazagira PET scan. Abitabiriye amahugurwa bazakomeza kwivuza igihe cyose babyihanganiye kandi KS yabo igatera imbere. Nyuma yo kuvurwa, bazasurwa inshuro nyinshi kubakurikirana kugeza kumyaka 5 ... Abitabiriye virusi itera sida bazagira imiti igabanya ubukana bwa virusi. Bamwe mubitabiriye amahugurwa bazagira PET scan. Abitabiriye amahugurwa bazakomeza kwivuza igihe cyose babyihanganiye kandi KS yabo igatera imbere. Nyuma yo kuvurwa, bazasurwa inshuro nyinshi kubakurikirana kugeza kumyaka 5 ... Abitabiriye virusi itera sida bazagira imiti igabanya ubukana bwa virusi. Bamwe mubitabiriye amahugurwa bazagira PET scan. Abitabiriye amahugurwa bazakomeza kwivuza igihe cyose babyihanganiye kandi KS yabo igatera imbere. Nyuma yo kuvurwa, bazasurwa inshuro nyinshi kugeza kumyaka 5 ...
Aho biherereye: Ikigo cyigihugu cyita ku buzima Clinical Centre, Bethesda, Maryland
