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Chithandizo cha Pancreatic Neuroendocrine Tumors (Islet Cell Tumors) (®) -Patient Version

Zambiri Pancreatic Neuroendocrine Tumors (Islet Cell Tumors)

MFUNDO ZOFUNIKA

  • Zotupa za Pancreatic neuroendocrine zimapangidwa m'maselo opanga ma hormone (islet cell) am'mapapo.
  • Ma NET a Pancreatic amatha kapena sangayambitse zizindikilo kapena zizindikilo.
  • Pali mitundu yosiyanasiyana ya ma pancreatic NET ogwira ntchito.
  • Kukhala ndi ma syndromes ena kumatha kuonjezera chiopsezo cha ma pancreatic NET.
  • Mitundu yosiyanasiyana yama pancreatic NET ili ndi zizindikilo zosiyanasiyana.
  • Mayeso a labu ndi kuyerekezera kwamawonekedwe amagwiritsidwa ntchito kuti apeze (kupeza) ndikuzindikira ma NET a kapamba.
  • Mitundu ina yamayeso a labu imagwiritsidwa ntchito kuyang'ana mtundu wa ma pancreatic NET.
  • Zinthu zina zimakhudzanso madandaulo (mwayi wochira) ndi njira zamankhwala.

Zotupa za Pancreatic neuroendocrine zimapangidwa m'maselo opanga ma hormone (islet cell) am'mapapo.

Mphunoyi ndi kansalu kotalika pafupifupi mainchesi 6 kamene kamaoneka ngati peyala woonda atagona chammbali. Mapeto ake onse otchedwa pancreas amatchedwa mutu, gawo lapakati limatchedwa thupi, ndipo kumapeto kwake ndi mchira. Mphunoyi ili kumbuyo kwa mimba komanso kutsogolo kwa msana.

Anatomy ya kapamba. Mphunoyi ili ndi mbali zitatu: mutu, thupi, ndi mchira. Amapezeka pamimba pafupi ndi mimba, matumbo, ndi ziwalo zina.

Pali mitundu iwiri yamaselo m'matendawa:

  • Maselo a endocrine pancreas amapanga mitundu ingapo yamahomoni (mankhwala omwe amayang'anira zochita za maselo ena kapena ziwalo m'thupi), monga insulin yoyang'anira shuga wamagazi. Amasonkhana pamodzi m'magulu ang'onoang'ono (zilumba) ponseponse m'mapiko. Maselo a endocrine pancreas amatchedwanso kuti islet cell kapena zilumba za Langerhans. Zotupa zomwe zimapangidwa m'maselo azisumbu zimatchedwa islet cell tumors, zotupa za pancreatic endocrine, kapena zotupa za pancreatic neuroendocrine (pancreatic NETs).
  • Maselo opangidwa ndi zotupa zotchedwa Exocrine cell amapanga ma michere omwe amatulutsidwa m'matumbo ang'onoang'ono kuti athandize thupi kugaya chakudya. Mphepete zambiri zimapangidwa ndi timadontho tokhala ndi timatumba tating'onoting'ono kumapeto kwa timabowo, tomwe timakhala ndi maselo am'mimba.

Chidule ichi chikufotokoza zotupa zam'mimba zam'mimba za endocrine. Onani chidule cha pa Pancreatic Cancer Treatment (Wamkulu) kuti mumve zambiri za khansa ya pancreatic.

Zotupa za Pancreatic neuroendocrine (NETs) zitha kukhala zoyipa (osati khansa) kapena zoyipa (khansa). Ma pancreatic NETs ali owopsa, amatchedwa khansa ya pancreatic endocrine kapena islet cell carcinoma.

Ma Pancreatic NETs ndiofala kwambiri kuposa zotupa za pancreatic exocrine ndipo amakhala ndi chiyembekezo chabwinoko.

Ma NET a Pancreatic amatha kapena sangayambitse zizindikilo kapena zizindikilo.

Ma NET a Pancreatic atha kugwira ntchito kapena kusagwira ntchito:

  • Zotupa zogwira ntchito zimapanga mahomoni owonjezera, monga gastrin, insulin, ndi glucagon, omwe amayambitsa zizindikilo.
  • Zotupa zosagwira sizimapanga mahomoni owonjezera. Zizindikiro zimayambitsidwa ndi chotupacho pamene chimafalikira ndikukula. Zotupa zambiri zosagwira ndizoyipa (khansa).

Ma NET ambiri amtundu wa pancreatic ndimatumbo ogwira ntchito.

Pali mitundu yosiyanasiyana ya ma pancreatic NET ogwira ntchito.

Ma NET a Pancreatic amapanga mahomoni osiyanasiyana monga gastrin, insulin, ndi glucagon. Kugwira ntchito kwa ma pancreatic NET ndi awa:

  • Gastrinoma: Chotupa chomwe chimapangidwa m'maselo omwe amapanga gastrin. Gastrin ndi timadzi timene timayambitsa m'mimba kutulutsa asidi yemwe amathandiza kugaya chakudya. Onse gastrin ndi asidi m'mimba zimawonjezeka ndi gastrinomas. Akachuluka m'mimba acid, zilonda zam'mimba, ndi kutsekula m'mimba zimayambitsidwa ndi chotupa chomwe chimapanga gastrin, chimatchedwa matenda a Zollinger-Ellison. Gastrinoma nthawi zambiri imakhala pamutu pa kapamba ndipo nthawi zina imapangidwa m'matumbo ang'onoang'ono. Ma gastrinomas ambiri ndi owopsa (khansa).
  • Insulinoma: Chotupa chomwe chimapangidwa m'maselo omwe amapanga insulin. Insulini ndi timadzi tomwe timayang'anira kuchuluka kwa shuga (shuga) m'magazi. Imasunthira shuga m'maselo, momwe thupi limatha kugwiritsira ntchito mphamvu. Insulinomas nthawi zambiri amakhala zotupa zomwe sizimafalikira kawirikawiri. Mankhwala a insulinoma pamutu, thupi, kapena mchira wa kapamba. Insulinomas nthawi zambiri amakhala oopsa (osati khansa).
  • Glucagonoma: Chotupa chomwe chimapangidwa m'maselo omwe amapanga glucagon. Glucagon ndi hormone yomwe imakulitsa kuchuluka kwa shuga m'magazi. Amayambitsa chiwindi kuphwanya glycogen. Glucagon yochuluka imayambitsa hyperglycemia (shuga wambiri wamagazi). Glucagonoma nthawi zambiri imapangidwa mchira wa kapamba. Ma glucagonomas ambiri ndi owopsa (khansa).
  • Mitundu ina ya zotupa: Palinso mitundu ina yosawerengeka yama pancreatic NET omwe amapanga mahomoni, kuphatikiza mahomoni omwe amalamulira shuga, mchere, ndi madzi m'thupi. Zotupa izi ndi izi:
  • VIPomas, omwe amapanga vasoactive m'matumbo peputayidi. VIPoma amathanso kutchedwa Verner-Morrison syndrome.
  • Somatostatinomas, omwe amapanga somatostatin.

Mitundu ina iyi ya tumimba imagawidwa palimodzi chifukwa amathandizidwa chimodzimodzi.

Kukhala ndi ma syndromes ena kumatha kuonjezera chiopsezo cha ma pancreatic NET.

Chilichonse chomwe chimakulitsa chiopsezo chotenga matenda chimatchedwa chiopsezo. Kukhala ndi chiwopsezo sikutanthauza kuti udzakhala ndi khansa; kusakhala ndi zoopsa sikutanthauza kuti simudzakhala ndi khansa. Lankhulani ndi dokotala ngati mukuganiza kuti mutha kukhala pachiwopsezo.

Matenda angapo a endocrine neoplasia mtundu 1 (MEN1) ndi chiopsezo cha ma pancreatic NET.

Mitundu yosiyanasiyana yama pancreatic NET ili ndi zizindikilo zosiyanasiyana.

Zizindikiro zimatha chifukwa cha kukula kwa chotupacho komanso / kapena mahomoni omwe chotupacho chimapanga kapena zinthu zina. Zotupa zina sizimatha kuyambitsa zizindikilo. Funsani dokotala wanu ngati muli ndi mavuto amenewa.

Zizindikiro za Nanc pancreatic NET

Pancreatic NET yosagwira ntchito imatha kukula kwakanthawi popanda kuyambitsa zizindikilo. Itha kukula kwambiri kapena kufalikira mbali zina za thupi isanayambitse zizindikilo, monga:

  • Kutsekula m'mimba.
  • Kudzimbidwa.
  • Chotupa m'mimba.
  • Kupweteka m'mimba kapena kumbuyo.
  • Chikasu pakhungu ndi azungu amaso.

Zizindikiro za Nancreatic NET

Zizindikiro za pancreatic NET yogwira ntchito zimadalira mtundu wa mahomoni omwe amapangidwa.

Kuchuluka kwa gastrin kumatha kuyambitsa:

  • Zilonda zam'mimba zomwe zimabwerabe.
  • Kupweteka m'mimba, komwe kumatha kufalikira kumbuyo. Kupweteka kumatha kubwera ndikutha ndipo kumatha pambuyo poti atenga mankhwala ophera tizilombo.
  • Kutuluka kwam'mimba kubwerera kummero (gastroesophageal reflux).
  • Kutsekula m'mimba.

Kuchuluka kwa insulin kungayambitse:

  • Shuga wamagazi ochepa. Izi zitha kupangitsa kuti usamawone bwino, umve mutu, ndikumverera mutu, kutopa, kufooka, kugwedezeka, mantha, kukwiya, thukuta, kusokonezeka, kapena kumva njala.
  • Kugunda kwamtima.

Glucagon yochuluka ingayambitse:

  • Kutupa pakhungu kumaso, m'mimba, kapena miyendo.
  • Shuga wamagazi ambiri. Izi zimatha kupangitsa mutu, kukodza pafupipafupi, khungu louma ndi pakamwa, kapena kumva njala, ludzu, kutopa, kapena kufooka.
  • Kuundana kwamagazi. Kuundana kwamagazi m'mapapu kumatha kupangitsa kupuma pang'ono, kutsokomola, kapena kupweteka pachifuwa. Kuundana kwa magazi mkono kapena mwendo kumatha kupweteka, kutupa, kutentha, kapena kufiira kwa mkono kapena mwendo.
  • Kutsekula m'mimba.
  • Kuchepetsa thupi popanda chifukwa chodziwika.
  • Lilime lowawa kapena zilonda pamakona pakamwa.

Kuchuluka kwa vasoactive m'matumbo peptide (VIP) kumatha kuyambitsa:

  • Kutsekula m'madzi kwakukulu kwambiri.
  • Kutaya madzi m'thupi. Izi zitha kupangitsa kumva ludzu, kuchepa mkodzo, khungu louma ndi pakamwa, mutu, chizungulire, kapena kumva kutopa.
  • Potaziyamu wochepa m'magazi. Izi zitha kupangitsa kufooka kwa minofu, kupweteka, kapena kukokana, kufooka ndi kumva kulira, kukodza pafupipafupi, kugunda kwamtima, komanso kumva kusokonezeka kapena kumva ludzu.
  • Kukokana kapena kupweteka m'mimba.
  • Kuchepetsa thupi popanda chifukwa chodziwika.

Somatostatin yochuluka ingayambitse:

  • Shuga wamagazi ambiri. Izi zimatha kupangitsa mutu, kukodza pafupipafupi, khungu louma ndi pakamwa, kapena kumva njala, ludzu, kutopa, kapena kufooka.
  • Kutsekula m'mimba.
  • Steatorrhea (chopondapo chonunkha kwambiri chomwe chimayandama).
  • Miyala.
  • Chikasu pakhungu ndi azungu amaso.
  • Kuchepetsa thupi popanda chifukwa chodziwika.

Pancreatic NET itha kupanganso mahomoni ochulukirapo a adrenocorticotropic (ACTH) ndikupangitsa matenda a Cushing. Zizindikiro za Cushing syndrome ndi izi:

  • Mutu.
  • Kutaya kwina kwa masomphenya.
  • Kulemera pamaso, pakhosi, ndi thunthu lamthupi, ndi manja ndi miyendo yopyapyala.
  • Mtolo wamafuta kumbuyo kwa khosi.
  • Khungu locheperako lomwe limatha kukhala ndi zofiirira kapena pinki zotambalala pachifuwa kapena pamimba.
  • Kuvulaza kosavuta.
  • Kukula kwa tsitsi labwino pamaso, kumtunda, kapena mikono.
  • Mafupa omwe amathyoka mosavuta.
  • Zilonda kapena mabala omwe amachira pang'onopang'ono.
  • Kuda nkhawa, kukwiya, komanso kukhumudwa.

Chithandizo cha ma pancreatic NET omwe amapanga ACTH yambiri ndi Cushing syndrome sanafotokozedwe mwachidule.

Mayeso a labu ndi kuyerekezera kwamawonekedwe amagwiritsidwa ntchito kuti apeze (kupeza) ndikuzindikira ma NET a kapamba.

Mayeso ndi njira zotsatirazi zitha kugwiritsidwa ntchito:

  • Kuwunika kwakuthupi ndi mbiri: Kuyesedwa kwa thupi kuti muwone zizindikiritso zaumoyo, kuphatikiza kuyang'ana ngati pali matenda, monga zotupa kapena china chilichonse chomwe chikuwoneka chachilendo. Mbiri yokhudzana ndi thanzi la wodwalayo komanso matenda am'mbuyomu komanso chithandizo chamankhwala adzachitidwanso.
  • Kafukufuku wamagazi: Njira yoyeserera magazi kuti ayese kuchuluka kwa zinthu zina, monga shuga (shuga), yotulutsidwa m'magazi ndi ziwalo ndi minyewa mthupi. Kuchuluka kwazinthu zosazolowereka (zakumwamba kapena zochepa) kungakhale chizindikiro cha matenda.
  • Chromogranin A test: Kuyesedwa komwe kuyezetsa magazi amayesa kuchuluka kwa chromogranin A m'magazi. Kuchuluka kwa chromogranin A komanso kuchuluka kwa mahomoni monga gastrin, insulin, ndi glucagon kumatha kukhala chizindikiro cha NET yopanda ntchito.
  • Mimba ya CT scan (CAT scan): Njira yomwe imapanga zithunzi zingapo zam'mimba, zojambulidwa mosiyanasiyana. Zithunzizo zimapangidwa ndi kompyuta yolumikizidwa ndi makina a x-ray. Utoto ukhoza kulowetsedwa mumtsempha kapena kumeza kuti ziwalo kapena ziwalo ziwoneke bwino. Njirayi imatchedwanso computed tomography, kompyuta tomography, kapena kompyuta axial tomography.
  • MRI (magnetic resonance imaging): Njira yomwe imagwiritsa ntchito maginito, mafunde a wailesi, ndi kompyuta kuti ipange zithunzi zingapo za malo amkati mwa thupi. Njirayi imatchedwanso nuclear magnetic resonance imaging (NMRI).
  • Somatostatin receptor scintigraphy: Mtundu wa radionuclide scan womwe ungagwiritsidwe ntchito kupeza ma NET ang'onoang'ono a pancreatic. Octreotide wocheperako poizoni (mahomoni omwe amangirira zotupa) amalowetsedwa mumtsempha ndikuyenda m'magazi. Octreotide wama radioact amata chotupacho ndipo kamera yapadera yomwe imazindikira kuti radioactivity imagwiritsidwa ntchito kuwonetsa komwe kuli zotupa mthupi. Njirayi imatchedwanso octreotide scan ndi SRS.
  • Endoscopic ultrasound (EUS): Njira yomwe endoscope imayikidwa mthupi, nthawi zambiri kudzera pakamwa kapena m'matumbo. Endoscope ndi chida chopyapyala, chokhala ngati chubu chokhala ndi kuwala ndi mandala owonera. Kafukufuku kumapeto kwa endoscope amagwiritsidwa ntchito kuphulitsa mafunde amphamvu kwambiri (ultrasound) pamatumba amkati kapena ziwalo ndikupanga mawonekedwe. Zolembawo amapanga chithunzi cha matupi amthupi otchedwa sonogram. Njirayi imatchedwanso endosonography.
  • Endoscopic retrograde cholangiopancreatography (ERCP):Njira yogwiritsira ntchito X-ray ducts (machubu) omwe amanyamula bile kuchokera pachiwindi kupita ku ndulu komanso kuchokera ku ndulu kupita kumatumbo ang'onoang'ono. Nthawi zina khansa ya pancreatic imapangitsa kuti mitengoyi ichepetse komanso kutseka kapena kuchepetsa kutuluka kwa ndulu, kuyambitsa matenda a chikasu. Endoscope imadutsa pakamwa, pammero, ndi m'mimba kulowa gawo loyamba la m'mimba. Endoscope ndi chida chopyapyala, chokhala ngati chubu chokhala ndi kuwala ndi mandala owonera. Catheter (kachubu kakang'ono) kenaka imayikidwa kudzera mu endoscope m'miphika ya kapamba. Utoto umabayidwa kudzera mu catheter mu ducts ndipo x-ray imatengedwa. Ngati ngalandezo zatsekedwa ndi chotupa, chubu chabwino chitha kulowetsedwa mumsewu kuti chimatsegule. Chubu ichi (kapena stent) chitha kusiya m'malo kuti pakhale njira yotseguka. Zitsanzo zamatenda amathanso kutengedwa ndikuwunikidwa pansi pa microscope ngati ali ndi khansa.
  • Angiogram: Ndondomeko yoyang'ana mitsempha yamagazi ndi magazi. Utoto wosiyana umalowetsedwa mumtsuko wamagazi. Dye wosiyanayo akamadutsa mumtsuko wamagazi, ma x-ray amatengedwa kuti awone ngati pali zotchinga zilizonse.
  • Laparotomy: Njira yochitira opareshoni yomwe imadulidwa pakhoma pamimba kuti ayang'ane mkati mwa mimba ngati muli ndi matenda. Kukula kwa katemera kumadalira chifukwa chomwe laparotomy ikuchitidwira. Nthawi zina ziwalo zimachotsedwa kapena zitsanzo za minofu zimatengedwa ndikufufuzidwa pa microscope ngati pali matenda.
  • Intraoperative ultrasound: Njira yomwe imagwiritsa ntchito mafunde amphamvu kwambiri (ultrasound) kupanga zithunzi zamkati kapena zotupa mukamachita opareshoni. Transducer yoyikidwa mwachindunji pa chiwalo kapena minofu imagwiritsidwa ntchito kupanga mafunde amawu, omwe amapanga ma echoes. Transducer amalandira ma echoes ndikuwatumiza ku kompyuta, yomwe imagwiritsa ntchito ma echoes kupanga zithunzi zotchedwa sonograms.
  • Biopsy: Kuchotsa kwa maselo kapena ziphuphu kotero kuti amatha kuwonedwa ndi microscope ndi wodwalayo kuti aone ngati ali ndi khansa. Pali njira zingapo zopangira biopsy ya ma pancreatic NETs. Maselo atha kuchotsedwa pogwiritsa ntchito singano yabwino kapena yayikulu yolowetsedwa m'mapapo panthawi ya x-ray kapena ultrasound. Minofu itha kuchotsedwanso pa laparoscopy (kapangidwe kake kopangira pamimba).
  • Kujambula mafupa: Njira yowunika ngati pali magawo omwe amagawa mwachangu, monga maselo a khansa, m'mafupa. Katundu wocheperako kwambiri wa jakisoni amalowetsedwa mumtsempha ndikuyenda m'magazi. Zinthu zowulutsa nyukiliya zimasonkhanitsa m'mafupa omwe ali ndi khansa ndipo amadziwika ndi sikani.

Mitundu ina yamayeso a labu imagwiritsidwa ntchito kuyang'ana mtundu wa ma pancreatic NET.

Mayeso ndi njira zotsatirazi zitha kugwiritsidwa ntchito:

Mimba

  • Kusala kudya kwa seramu gastrin: Kuyesedwa komwe kuyezetsa magazi kumayeza kuchuluka kwa gastrin m'magazi. Kuyesaku kumachitika wodwalayo atakhala wopanda kanthu kakudya kapena kumwa kwa maola 8. Zinthu zina kupatula gastrinoma zimatha kuyambitsa kuchuluka kwa gastrin m'magazi.
  • Chiyeso cha basal acid: Kuyesa kuyeza kuchuluka kwa asidi opangidwa ndi m'mimba. Kuyesaku kumachitika wodwalayo atakhala wopanda kanthu kakudya kapena kumwa kwa maola 8. Chubu chimalowetsedwa kudzera pamphuno kapena pakhosi, m'mimba. Zomwe zili m'mimba zimachotsedwa ndipo zitsanzo zinayi za gastric acid zimachotsedwa kudzera mu chubu. Zitsanzozi zimagwiritsidwa ntchito kuti mupeze kuchuluka kwa asidi m'mimba omwe amapangidwa poyesa komanso kuchuluka kwa pH kwa zotsekemera zam'mimba.
  • Kuyeserera kokopa kwa Secretin: Ngati zotsatira zoyambira za basal acid sizachilendo, mayeso oyeserera a secretin atha kuchitidwa. Chitoliro chimasunthira m'matumbo ang'onoang'ono ndipo zitsanzo zimachotsedwa m'matumbo ang'onoang'ono pambuyo poti mankhwala obisika a secretin abayidwa. Secretin amachititsa kuti matumbo ang'onoang'ono apange asidi. Pomwe pali gastrinoma, secretin imayambitsa kuchuluka kwa kuchuluka kwa m'mimba acid komanso kuchuluka kwa gastrin m'magazi.
  • Somatostatin receptor scintigraphy: Mtundu wa radionuclide scan womwe ungagwiritsidwe ntchito kupeza ma NET ang'onoang'ono a pancreatic. Octreotide wocheperako poizoni (mahomoni omwe amangirira zotupa) amalowetsedwa mumtsempha ndikuyenda m'magazi. Octreotide wama radioact amata chotupacho ndipo kamera yapadera yomwe imazindikira kuti radioactivity imagwiritsidwa ntchito kuwonetsa komwe kuli zotupa mthupi. Njirayi imatchedwanso octreotide scan ndi SRS.

Insulinoma

  • Kusala kudya kwa seramu ndi kuyezetsa insulini: Kuyesedwa komwe kuyezetsa magazi kumayeza kuchuluka kwa shuga (shuga) ndi insulin m'magazi. Kuyesaku kumachitika wodwalayo atakhala wopanda kanthu kakudya kapena kumwa kwa maola 24.

Glucagonoma [[[[

  • Kusala kudya kwa seramu glucagon: Kuyesedwa komwe kuyezetsa magazi kumayeza kuchuluka kwa glucagon m'magazi. Kuyesaku kumachitika pambuyo poti wodwala alibe chilichonse choti adye kapena kumwa kwa maola 8.

Mitundu ina yotupa

  • VIPoma
  • Serum VIP (vasoactive intestinal peptide) mayeso: Kuyesedwa komwe kuyesa magazi kumayeza kuchuluka kwa VIP.
  • Kafukufuku wamagazi: Njira yoyeserera magazi kuti ayese kuchuluka kwa zinthu zina zomwe zimatulutsidwa m'magazi ndi ziwalo ndi minyewa mthupi. Kuchuluka kwazinthu zosazolowereka (zakumwamba kapena zochepa) kungakhale chizindikiro cha matenda. Ku VIPoma, pali potaziyamu yocheperako kuposa yachibadwa.
  • Kusanthula chopondapo : Choyesera chopondapo chimayang'aniridwa kuti chikhale ndi sodium wochuluka kwambiri (mchere) ndi potaziyamu.
  • Somatostatinoma
  • Kusala kudya kwa seramu somatostatin: Kuyesedwa komwe kuyezetsa magazi kumayeza kuchuluka kwa somatostatin m'magazi. Kuyesaku kumachitika wodwalayo atakhala wopanda kanthu kakudya kapena kumwa kwa maola 8.
  • Somatostatin receptor scintigraphy: Mtundu wa radionuclide scan womwe ungagwiritsidwe ntchito kupeza ma NET ang'onoang'ono a pancreatic. Octreotide wocheperako poizoni (mahomoni omwe amangirira zotupa) amalowetsedwa mumtsempha ndikuyenda m'magazi. Octreotide wama radioact amata chotupacho ndipo kamera yapadera yomwe imazindikira kuti radioactivity imagwiritsidwa ntchito kuwonetsa komwe kuli zotupa mthupi. Njirayi imatchedwanso octreotide scan ndi SRS.

Zinthu zina zimakhudzanso madandaulo (mwayi wochira) ndi njira zamankhwala.

Ma NET a Pancreatic amatha kuchiritsidwa. Kulosera (mwayi wochira) ndi njira zamankhwala zimadalira izi:

  • Mtundu wa khansa.
  • Kumene chotupacho chimapezeka m'mapiko.
  • Kaya chotupacho chafalikira m'malo oposera amodzi m'mapapo kapena mbali zina za thupi.
  • Kaya wodwalayo ali ndi matenda a MEN1.
  • Msinkhu wa wodwalayo komanso thanzi lake lonse.
  • Kaya khansa yapezeka kumene kapena yabwereranso (bwererani).

Magawo a Zotupa za Pancreatic Neuroendocrine

MFUNDO ZOFUNIKA

  • Dongosolo la chithandizo cha khansa limadalira komwe NET imapezeka m'mankhwala komanso ngati yafalikira.
  • Pali njira zitatu zomwe khansa imafalikira mthupi.
  • Khansa imatha kufalikira pomwe idayamba kupita mbali zina za thupi.

Dongosolo la chithandizo cha khansa limadalira komwe NET imapezeka m'mankhwala komanso ngati yafalikira.

Njira yomwe amagwiritsidwa ntchito pofufuza ngati khansara yafalikira mkati kapangidwe kapenanso mbali zina za thupi amatchedwa staging. Zotsatira za mayeso ndi njira zomwe zimagwiritsidwa ntchito pozindikira zotupa za pancreatic neuroendocrine (NETs) zimagwiritsidwanso ntchito kudziwa ngati khansara yafalikira. Onani gawo la General Information kuti mumve zambiri za mayeserowa ndi njirazi.

Ngakhale pali njira zofananira zama pancreatic NETs, ​​sizigwiritsidwa ntchito kukonzekera chithandizo. Kuchiza kwa ma pancreatic NETs kutengera izi:

  • Kaya khansara imapezeka pamalo amodzi m'matenda.
  • Kaya khansara imapezeka m'malo angapo m'mimba.
  • Kaya khansara yafalikira ku ma lymph node pafupi ndi kapamba kapena mbali zina za thupi monga chiwindi, mapapo, peritoneum, kapena fupa.

Pali njira zitatu zomwe khansa imafalikira mthupi.

Khansa imatha kufalikira kudzera mu minofu, ma lymph system, ndi magazi:

  • Minofu. Khansara imafalikira kuchokera pomwe idayamba ndikukula kupita kumadera oyandikana nawo.
  • Lymph dongosolo. Khansara imafalikira kuchokera pomwe idayamba polowa m'mitsempha. Khansara imadutsa m'mitsempha yamafuta kupita mbali zina za thupi.
  • Magazi. Khansara imafalikira kuchokera pomwe idayamba ndikulowa m'magazi. Khansara imadutsa m'mitsempha yamagazi kupita mbali zina za thupi.

Khansa imatha kufalikira pomwe idayamba kupita mbali zina za thupi.

Khansa ikafalikira mbali ina ya thupi, imatchedwa metastasis. Maselo a khansa amachoka pomwe adayamba (chotupa choyambirira) ndikuyenda mumitsempha kapena magazi.

  • Lymph dongosolo. Khansara imalowa mumitsempha, imadutsa m'mitsempha yamafuta, ndikupanga chotupa (chotupa cha metastatic) gawo lina la thupi.
  • Magazi. Khansara imalowa m'magazi, imadutsa m'mitsempha yamagazi, ndikupanga chotupa (chotupa cha metastatic) gawo lina la thupi.

Chotupacho chimakhala chotupa chimodzimodzi. Mwachitsanzo, ngati chotupa cha pancreatic neuroendocrine chimafalikira pachiwindi, zotupa m'chiwindi ndizotupa za neuroendocrine. Matendawa ndi chotupa cha pancreatic neuroendocrine chotupa, osati khansa ya chiwindi.

Zotupa Zaposachedwa za Pancreatic Neuroendocrine

Zotupitsa zaposachedwa za neuroendocrine zotupa (NETs) ndi zotupa zomwe zabwereranso (kubwerera) atalandira chithandizo. Zotupazo zimatha kubwerera m'mapiko kapena mbali zina za thupi.

Chithandizo Chosankha Mwachidule

MFUNDO ZOFUNIKA

  • Pali mitundu yosiyanasiyana ya chithandizo cha odwala omwe ali ndi ma pancreatic NET.
  • Mitundu isanu ndi umodzi yamankhwalawa amagwiritsidwa ntchito:
  • Opaleshoni
  • Chemotherapy
  • Thandizo la mahomoni
  • Kutsekemera kwamatsenga kapena chemoembolization
  • Chithandizo chofuna
  • Chithandizo chothandizira
  • Mitundu yatsopano yamankhwala ikuyesedwa m'mayesero azachipatala.
  • Chithandizo cha zotupa za pancreatic neuroendocrine zitha kuyambitsa zovuta.
  • Odwala angaganize zopita nawo kukayezetsa.
  • Odwala amatha kulowa m'mayesero azachipatala asanayambe, asanayambe, kapena atayamba kulandira chithandizo cha khansa.
  • Mayeso otsatirawa angafunike.

Pali mitundu yosiyanasiyana ya chithandizo cha odwala omwe ali ndi ma pancreatic NET.

Pali mitundu ingapo yamankhwala othandizira odwala omwe ali ndi zotupa za pancreatic neuroendocrine (NETs). Mankhwala ena ndi ofanana (mankhwala omwe akugwiritsidwa ntchito pano), ndipo ena akuyesedwa m'mayesero azachipatala. Kuyesedwa kwachipatala ndi kafukufuku wofufuza wothandizira kusintha chithandizo chamakono kapena kupeza zidziwitso zamankhwala atsopano kwa odwala khansa. Pamene mayesero azachipatala awonetsa kuti chithandizo chatsopano ndichabwino kuposa chithandizo chamankhwala, chithandizocho chitha kukhala chamankhwala wamba. Odwala angaganize zopita nawo kukayezetsa. Mayesero ena azachipatala ndi otseguka kwa odwala omwe sanayambe kulandira chithandizo.

Mitundu isanu ndi umodzi yamankhwalawa amagwiritsidwa ntchito:

Opaleshoni

Atha kuchitidwa opaleshoni kuti achotse chotupacho. Imodzi mwa mitundu yotsatirayi ingagwiritsidwe ntchito:

  • Kuphulika: Kuchita opareshoni kuchotsa chotupa chokha. Izi zitha kuchitika khansa ikachitika pamalo amodzi m'mankhwala.
  • Pancreatoduodenectomy: Njira yochitira opaleshoni yomwe mutu wa kapamba, ndulu, ma lymph node oyandikira komanso gawo lina la m'mimba, matumbo ang'onoang'ono, ndi chotupa cha bile zimachotsedwa. Mpheta zimasowa kuti zizipanga timadziti ndi insulin. Ziwalo zomwe zimachotsedwa panthawiyi zimadalira momwe wodwalayo alili. Izi zimatchedwanso njira ya Whipple.
  • Distre pancreatectomy: Opaleshoni yochotsa thupi ndi mchira wa kapamba. Nthata imathanso kuchotsedwa ngati khansara yafalikira ku ndulu.
  • Total gastrectomy: Opaleshoni kuchotsa m'mimba monse.
  • Parietal cell vagotomy: Kuchita opaleshoni kudula mitsempha yomwe imapangitsa kuti maselo am'mimba apange acid.
  • Kutulutsa chiwindi: Opaleshoni yochotsa gawo kapena chiwindi chonse.
  • Kuchotsa ma Radiofrequency: Kugwiritsa ntchito kafukufuku wapadera wokhala ndi maelekitirodi ang'onoang'ono omwe amapha ma cell a khansa. Nthawi zina kafukufuku amalowetsedwa kudzera pakhungu ndipo amangofunika ochititsa dzanzi m'deralo. Nthawi zina, kafukufuku amalowetsedwa kudzera pachimbudzi m'mimba. Izi zimachitika mchipatala ndi anesthesia wamba.
  • Kuchepetsa khungu: Njira yomwe mafinya amaundana kuti awononge maselo achilendo. Izi zimachitika kawirikawiri ndi chida chapadera chomwe chimakhala ndi nayitrogeni wamadzi kapena madzi a kaboni dayokisaidi. Chidacho chingagwiritsidwe ntchito popanga opaleshoni kapena laparoscopy kapena kuyikika kudzera pakhungu. Njirayi imatchedwanso cryoablation.

Chemotherapy

Chemotherapy ndi mankhwala a khansa omwe amagwiritsa ntchito mankhwala oletsa kukula kwa maselo a khansa, mwina popha ma cell kapena kuwaletsa kuti asagawane. Chemotherapy ikamamwa pakamwa kapena kulowetsedwa mumtsempha kapena minofu, mankhwalawa amalowa m'magazi ndipo amatha kufikira ma cell a khansa mthupi lonse (systemic chemotherapy). Chemotherapy ikaikidwa molunjika m'matumbo a cerebrospinal, chiwalo, kapena thupi ngati pamimba, mankhwalawa amakhudza kwambiri ma cell a khansa m'malo amenewo (chemotherapy am'madera). Mgwirizano wa chemotherapy ndi kugwiritsa ntchito mankhwala opatsirana angapo opatsirana khansa. Momwe chemotherapy imaperekedwa imadalira mtundu wa khansa yomwe ikuchitidwa.

Thandizo la mahomoni

Thandizo la mahomoni ndi mankhwala a khansa omwe amachotsa mahomoni kapena amalepheretsa zochita zawo ndikuletsa maselo a khansa kuti asakule. Mahomoni ndi zinthu zopangidwa ndi tiziwalo timene timatuluka m'thupi ndipo timafalikira m'magazi. Mahomoni ena amatha kupangitsa khansa kukula. Ngati kuyesa kukuwonetsa kuti ma cell a khansa ali ndi malo omwe mahomoni amatha kulumikiza (receptors), mankhwala osokoneza bongo, opareshoni, kapena mankhwala a radiation amagwiritsidwa ntchito pochepetsa mahomoni kapena kuwaletsa kugwira ntchito.

Kutsekemera kwamatsenga kapena chemoembolization

Kutsekeka kwamatenda a hepatic kumagwiritsa ntchito mankhwala, tinthu tating'onoting'ono, kapena othandizira ena kuti atseke kapena kuchepetsa kuthamanga kwa magazi kupita pachiwindi kudzera mumitsempha yam'mimba (chotengera chachikulu chamagazi chomwe chimanyamula magazi kupita ku chiwindi). Izi zachitika kupha ma cell a khansa omwe akukula m'chiwindi. Chotupacho chimalephera kupeza mpweya ndi michere yomwe imafunikira kukula. Chiwindi chimapitilizabe kulandira magazi kuchokera pamitsempha yotsegula, yomwe imanyamula magazi kuchokera m'mimba ndi m'matumbo.

Chemotherapy yomwe imaperekedwa panthawi yoopsa kwambiri yotchedwa chemoembolization. Mankhwala oletsa khansa amabayidwa mumitsempha ya hepatic kudzera mu catheter (chubu chochepa). Mankhwalawa amasakanikirana ndi chinthu chomwe chimatseka mtsempha wamagazi ndikuchepetsa magazi kutuluka chotupa. Mankhwala ambiri a anticancer atsekedwa pafupi ndi chotupacho ndipo pang'ono pokha mankhwalawo amafika mbali zina za thupi.

Kutsekeka kumatha kukhala kwakanthawi kapena kosatha, kutengera chinthu chomwe chimagwiritsa ntchito kutseka mtsempha.

Chithandizo chofuna

Chithandizo choyenera ndi mtundu wa mankhwala omwe amagwiritsa ntchito mankhwala osokoneza bongo kapena zinthu zina kuti azindikire ndikuukira maselo amtundu wa khansa osavulaza maselo abwinobwino. Mitundu ina yamankhwala omwe akuwunikiridwa akuwerengedwa pochiza ma pancreatic NETs.

Chithandizo chothandizira

Thandizo lothandizira limaperekedwa kuti muchepetse mavuto omwe amabwera chifukwa cha matendawa kapena chithandizo chake. Kusamalira ma NET a kapamba kungaphatikizepo chithandizo cha zotsatirazi:

  • Zilonda zam'mimba zitha kuchiritsidwa ndi mankhwala monga:
  • Proton pump inhibitor mankhwala monga omeprazole, lansoprazole, kapena pantoprazole.
  • Mankhwala oletsa mbiri yakale monga cimetidine, ranitidine, kapena famotidine.
  • Mankhwala amtundu wa Somatostatin monga octreotide.
  • Kutsekula m'mimba kungathandizidwe ndi:
  • Madzi amkati (IV) okhala ndi ma electrolyte monga potaziyamu kapena mankhwala enaake.
  • Mankhwala amtundu wa Somatostatin monga octreotide.
  • Shuga wotsika m'magazi amatha kuthandizidwa pakudya pang'ono, pafupipafupi kapena ndi mankhwala osokoneza bongo kuti mukhale ndi shuga wabwino wamagazi.
  • Shuga wamagazi atha kuchiritsidwa ndi mankhwala omwe amamwa pakamwa kapena insulin ndi jakisoni.

Mitundu yatsopano yamankhwala ikuyesedwa m'mayesero azachipatala.

Zambiri zamayeso azachipatala zimapezeka patsamba la NCI.

Chithandizo cha zotupa za pancreatic neuroendocrine zitha kuyambitsa zovuta.

Kuti mumve zambiri zamankhwala obwera chifukwa cha khansa, onani tsamba lathu la Zotsatira Zotsatira.

Odwala angaganize zopita nawo kukayezetsa.

Kwa odwala ena, kutenga nawo mbali pakuyesa chithandizo chachipatala kungakhale njira yabwino kwambiri yothandizira. Mayesero azachipatala ndi gawo limodzi la kafukufuku wa khansa. Mayesero azachipatala amachitika kuti apeze ngati mankhwala atsopano a khansa ndi otetezeka komanso ogwira ntchito kapena abwinoko kuposa mankhwala wamba.

Njira zambiri zamankhwala zochiritsira khansa zimachokera kumayeso am'mbuyomu azachipatala. Odwala omwe amatenga nawo mbali pachipatala atha kulandira chithandizo chofananira kapena kukhala oyamba kulandira chithandizo chatsopano.

Odwala omwe amatenga nawo mbali pazoyeserera zamankhwala amathandizanso kukonza momwe khansa idzathandizire mtsogolo. Ngakhale mayesero azachipatala satsogolera kuchipatala chatsopano, nthawi zambiri amayankha mafunso ofunikira ndikuthandizira kupititsa patsogolo kafukufuku.

Odwala amatha kulowa m'mayesero azachipatala asanayambe, asanayambe, kapena atayamba kulandira chithandizo cha khansa.

Mayesero ena azachipatala amangophatikizapo odwala omwe sanalandire chithandizo. Mayesero ena amayesa chithandizo kwa odwala omwe khansa yawo sinakhale bwino. Palinso mayesero azachipatala omwe amayesa njira zatsopano zothetsera khansa kuti isabwererenso (kubwerera) kapena kuchepetsa zovuta zoyambitsidwa ndi khansa.

Mayesero azachipatala akuchitika m'malo ambiri mdziko muno. Zambiri zamayeso azachipatala othandizidwa ndi NCI zitha kupezeka patsamba lofufuza zamankhwala la NCI. Mayesero azachipatala othandizidwa ndi mabungwe ena amapezeka patsamba la ClinicalTrials.gov.

Mayeso otsatirawa angafunike.

Ena mwa mayesero omwe adachitika kuti apeze khansa kapena kuti adziwe momwe khansa iliri angabwerezedwenso. Mayesero ena adzabwerezedwa kuti awone momwe mankhwalawa akugwirira ntchito. Zisankho zakuti mupitilize, kusintha, kapena kusiya kulandira chithandizo zitha kutengera zotsatira za mayeso awa.

Kuyesaku kumangopitilira kuchitika nthawi ndi nthawi mankhwala atatha. Zotsatira zamayesowa zitha kuwonetsa ngati vuto lanu lasintha kapena ngati khansa yabwereranso (bwererani). Mayesowa nthawi zina amatchedwa kuyesa kutsata kapena kukayezetsa.

Njira Zothandizira Pancreatic Neuroendocrine Tumors

M'chigawo chino

  • Mimba
  • Insulinoma
  • Glucagonoma
  • Zotupa Zina za Pancreatic Neuroendocrine (Islet Cell Tumors)
  • Zotulutsa Pancreatic Neuroendocrine Porscheic Recurrent kapena Progressive (Islet Cell Tumors)

Kuti mumve zambiri zamankhwala omwe atchulidwa pansipa, onani gawo la Chisankho Chachidule.

Mimba

Chithandizo cha gastrinoma chingaphatikizepo chisamaliro chothandizira ndi izi:

  • Pazizindikiro zoyambitsidwa ndi asidi wamimba wambiri, chithandizo chitha kukhala mankhwala omwe amachepetsa kuchuluka kwa asidi opangidwa ndi m'mimba.
  • Pamatumbo amodzi pamutu wa kapamba:
  • Opaleshoni kuchotsa chotupacho.
  • Kuchita maopaleshoni kuti muchepetse mitsempha yomwe imayambitsa maselo am'mimba kuti apange acid ndi chithandizo ndi mankhwala omwe amachepetsa asidi m'mimba.
  • Opaleshoni yochotsa m'mimba monse (osowa).
  • Kwa chotupa chimodzi mthupi kapena mchira wa kapamba, chithandizo nthawi zambiri chimakhala opaleshoni kuchotsa thupi kapena mchira wa kapamba.
  • Kwa zotupa zingapo m'mapapo, chithandizo nthawi zambiri chimakhala opaleshoni kuchotsa thupi kapena mchira wa kapamba. Ngati chotupa chimatsalira pambuyo pochitidwa opaleshoni, chithandizo chitha kuphatikizira izi:
  • Kuchita opaleshoni kudula mitsempha yomwe imapangitsa kuti maselo am'mimba apange acid ndi chithandizo ndi mankhwala omwe amachepetsa asidi m'mimba; kapena
  • Opaleshoni yochotsa m'mimba monse (osowa).
  • Kwa chotupa chimodzi kapena zingapo mu duodenum (gawo la m'matumbo ang'onoang'ono omwe amalumikizana ndi m'mimba), chithandizo nthawi zambiri chimakhala pancreatoduodenectomy (opaleshoni yochotsa mutu wa kapamba, ndulu, ma lymph node oyandikira komanso gawo la m'mimba, matumbo ang'ono , ndi ndulu ya bile).
  • Ngati palibe chotupa chomwe chikupezeka, chithandizo chingaphatikizepo izi:
  • Kuchita maopaleshoni kuti muchepetse mitsempha yomwe imayambitsa maselo am'mimba kuti apange acid ndi chithandizo ndi mankhwala omwe amachepetsa asidi m'mimba.
  • Opaleshoni yochotsa m'mimba monse (osowa).
  • Ngati khansara yafalikira pachiwindi, chithandizo chitha kukhala:
  • Opaleshoni kuchotsa gawo kapena chiwindi chonse.
  • Kuchotsa ma radiofrequency kapena cryosurgical ablation.
  • Chemoembolization.
  • Ngati khansa yafalikira mbali zina za thupi kapena sichichira bwino ndi opaleshoni kapena mankhwala ochepetsa asidi m'mimba, chithandizo chingaphatikizepo:
  • Chemotherapy.
  • Thandizo la mahomoni.
  • Ngati khansara imakhudza chiwindi ndipo wodwala ali ndi zizindikiro zoopsa za mahomoni kapena kukula kwa chotupa, chithandizo chitha kuphatikizira:
  • Kutsekemera kwamatenda kwamatenda, kapena popanda systemic chemotherapy.
  • Chemoembolization, kapena popanda systemic chemotherapy.

Gwiritsani ntchito kusaka kwathu kwamankhwala kuti mupeze mayesero azachipatala omwe amathandizidwa ndi NCI omwe akulandira odwala. Mutha kusaka mayesero kutengera mtundu wa khansa, zaka za wodwalayo, komanso komwe mayeserowo akuchitika. Zambiri pazokhudza mayesero azachipatala zimapezekanso.

Insulinoma

Chithandizo cha insulinoma chingaphatikizepo izi:

  • Pa chotupa chimodzi chaching'ono pamutu kapena mchira wa kapamba, chithandizo nthawi zambiri chimachitidwa opaleshoni kuchotsa chotupacho.
  • Pa chotupa chimodzi chachikulu m'mutu mwa kapamba chomwe sichingachotsedwe ndi opareshoni, chithandizo nthawi zambiri chimakhala pancreatoduodenectomy (opaleshoni yochotsa mutu wa kapamba, ndulu, ma lymph node oyandikira komanso gawo la m'mimba, matumbo ang'ono, ndi njira ya bile) .
  • Pa chotupa chimodzi chachikulu mthupi kapena mchira wa kapamba, chithandizo nthawi zambiri chimakhala distal pancreatectomy (opaleshoni yochotsa thupi ndi mchira wa kapamba).
  • Kwa chotupa choposa chimodzi m'mapapo, chithandizo nthawi zambiri chimakhala opaleshoni kuchotsa zotupa zilizonse m'mutu wa kapamba ndi thupi ndi mchira wa kapamba.
  • Kwa zotupa zomwe sizingachotsedwe ndi opaleshoni, chithandizo chitha kuphatikizira izi:
  • Kuphatikiza chemotherapy.
  • Mankhwala opatsirana ochepetsa mphamvu kuti achepetse kuchuluka kwa insulini yopangidwa ndi kapamba.
  • Thandizo la mahomoni.
  • Kuchotsa ma radiofrequency kapena cryosurgical ablation.
  • Khansa yomwe yafalikira kumatenda am'mimba kapena ziwalo zina za thupi, chithandizo chingaphatikizepo izi:
  • Opaleshoni kuchotsa khansara.
  • Kuchepetsa ma radiofrequency kapena cryosurgical ablation, ngati khansara singathe kuchotsedwa ndi opaleshoni.
  • Ngati khansara imakhudza chiwindi ndipo wodwala ali ndi zizindikiro zoopsa za mahomoni kapena kukula kwa chotupa, chithandizo chitha kuphatikizira:
  • Kutsekemera kwamatenda kwamatenda, kapena popanda systemic chemotherapy.
  • Chemoembolization, kapena popanda systemic chemotherapy.

Gwiritsani ntchito kusaka kwathu kwamankhwala kuti mupeze mayesero azachipatala omwe amathandizidwa ndi NCI omwe akulandira odwala. Mutha kusaka mayesero kutengera mtundu wa khansa, zaka za wodwalayo, komanso komwe mayeserowo akuchitika. Zambiri pazokhudza mayesero azachipatala zimapezekanso.

Glucagonoma

Chithandizo chingaphatikizepo izi:

  • Pa chotupa chimodzi chaching'ono pamutu kapena mchira wa kapamba, chithandizo nthawi zambiri chimachitidwa opaleshoni kuchotsa chotupacho.
  • Pa chotupa chimodzi chachikulu m'mutu mwa kapamba chomwe sichingachotsedwe ndi opareshoni, chithandizo nthawi zambiri chimakhala pancreatoduodenectomy (opaleshoni yochotsa mutu wa kapamba, ndulu, ma lymph node oyandikira komanso gawo la m'mimba, matumbo ang'ono, ndi njira ya bile) .
  • Kwa chotupa choposa chimodzi m'mapapo, chithandizo nthawi zambiri chimakhala opaleshoni kuchotsa chotupa kapena opareshoni yochotsa thupi ndi mchira wa kapamba.
  • Kwa zotupa zomwe sizingachotsedwe ndi opaleshoni, chithandizo chitha kuphatikizira izi:
  • Kuphatikiza chemotherapy.
  • Thandizo la mahomoni.
  • Kuchotsa ma radiofrequency kapena cryosurgical ablation.
  • Khansa yomwe yafalikira kumatenda am'mimba kapena ziwalo zina za thupi, chithandizo chingaphatikizepo izi:
  • Opaleshoni kuchotsa khansara.
  • Kuchepetsa ma radiofrequency kapena cryosurgical ablation, ngati khansara singathe kuchotsedwa ndi opaleshoni.
  • Ngati khansara imakhudza chiwindi ndipo wodwala ali ndi zizindikiro zoopsa za mahomoni kapena kukula kwa chotupa, chithandizo chitha kuphatikizira:
  • Kutsekemera kwamatenda kwamatenda, kapena popanda systemic chemotherapy.
  • Chemoembolization, kapena popanda systemic chemotherapy.

Gwiritsani ntchito kusaka kwathu kwamankhwala kuti mupeze mayesero azachipatala omwe amathandizidwa ndi NCI omwe akulandira odwala. Mutha kusaka mayesero kutengera mtundu wa khansa, zaka za wodwalayo, komanso komwe mayeserowo akuchitika. Zambiri pazokhudza mayesero azachipatala zimapezekanso.

Zotupa Zina za Pancreatic Neuroendocrine (Islet Cell Tumors)

Kwa VIPoma, chithandizo chitha kuphatikizira izi:

  • Zamadzimadzi ndi zamankhwala zamankhwala zimachotsa madzi ndi ma electrolyte omwe atayika mthupi.
  • Opaleshoni yochotsa chotupa ndi ma lymph node apafupi.
  • Kuchita opareshoni kuchotsa chotupa chochuluka momwe zingathere pomwe chotupacho sichingachotsedwe kwathunthu kapena chafalikira kumadera akutali a thupi. Awa ndi mankhwala ochepetsa nkhawa kuti athetse vuto ndikukhala ndi moyo wabwino.
  • Kwa zotupa zomwe zafalikira ku ma lymph node kapena ziwalo zina za thupi, chithandizo chingaphatikizepo izi:
  • Opaleshoni kuchotsa chotupacho.
  • Kuchepetsa ma radiofrequency kapena cryosurgical ablation, ngati chotupacho sichingachotsedwe ndi opaleshoni.
  • Zotupa zomwe zimapitilira kukula panthawi yachipatala kapena zafalikira mbali zina za thupi, chithandizo chingaphatikizepo izi:
  • Chemotherapy.
  • Chithandizo chofuna.

Kwa somatostatinoma, chithandizo chitha kuphatikizira izi:

  • Opaleshoni kuchotsa chotupacho.
  • Khansa yomwe yafalikira kumadera akutali a thupi, opareshoni kuti athetse khansa yambiri momwe angathere kuti athetse zizindikilo ndikukhala ndi moyo wabwino.
  • Zotupa zomwe zimapitilira kukula panthawi yachipatala kapena zafalikira mbali zina za thupi, chithandizo chingaphatikizepo izi:
  • Chemotherapy.
  • Chithandizo chofuna.

Chithandizo cha mitundu ina ya zotupa za pancreatic neuroendocrine (NETs) zitha kuphatikizira izi:

  • Opaleshoni kuchotsa chotupacho.
  • Khansa yomwe yafalikira kumadera akutali a thupi, opareshoni kuti athetse khansa yambiri momwe angathere kapena mankhwala a mahomoni kuti athetse zizindikilo ndikukhala ndi moyo wabwino.
  • Zotupa zomwe zimapitilira kukula panthawi yachipatala kapena zafalikira mbali zina za thupi, chithandizo chingaphatikizepo izi:
  • Chemotherapy.
  • Chithandizo chofuna.

Gwiritsani ntchito kusaka kwathu kwamankhwala kuti mupeze mayesero azachipatala omwe amathandizidwa ndi NCI omwe akulandira odwala. Mutha kusaka mayesero kutengera mtundu wa khansa, zaka za wodwalayo, komanso komwe mayeserowo akuchitika. Zambiri pazokhudza mayesero azachipatala zimapezekanso.

Zotulutsa Pancreatic Neuroendocrine Porscheic Recurrent kapena Progressive (Islet Cell Tumors)

Chithandizo cha zotupa za pancreatic neuroendocrine (NETs) zomwe zimapitilizabe kukula panthawi yamankhwala kapena kubwereranso (kubwerera) zitha kuphatikizira izi:

  • Opaleshoni kuchotsa chotupacho.
  • Chemotherapy.
  • Thandizo la mahomoni.
  • Chithandizo chofuna.
  • Kwa metastases ya chiwindi:
  • Chemotherapy m'chigawo.
  • Kutsekeka kwamatsenga kapena chemoembolization, kapena popanda systemic chemotherapy.
  • Kuyesedwa kwachipatala kwa mankhwala atsopano.

Gwiritsani ntchito kusaka kwathu kwamankhwala kuti mupeze mayesero azachipatala omwe amathandizidwa ndi NCI omwe akulandira odwala. Mutha kusaka mayesero kutengera mtundu wa khansa, zaka za wodwalayo, komanso komwe mayeserowo akuchitika. Zambiri pazokhudza mayesero azachipatala zimapezekanso.

Kuti mudziwe Zambiri Pancreatic Neuroendocrine Tumors (Islet Cell Tumors)

Kuti mumve zambiri kuchokera ku National Cancer Institute yokhudza zotupa za pancreatic neuroendocrine (NETs), onani izi:

  • Tsamba La Khansa Ya Pancreatic
  • Njira Zochizira Khansa

Kuti mumve zambiri za khansa ndi zinthu zina zochokera ku National Cancer Institute, onani izi:

  • Za Khansa
  • Kusinthana
  • Chemotherapy and You: Kuthandiza Anthu Omwe Ali Ndi Khansa
  • Thandizo la Radiation ndi Inu: Thandizo kwa Anthu Omwe Ali ndi Khansa
  • Kulimbana ndi khansa
  • Mafunso oti mufunse dokotala wanu za khansa
  • Kwa Opulumuka ndi Owasamalira


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