Mitundu / lymphoma / wodwala / primary-cns-lymphoma-treatment-pdq

Pulayimale CNS Lymphoma Treatment (®) -Patient Version

Zambiri Za Pulayimale CNS Lymphoma

MFUNDO ZOFUNIKA

• Njira yapakati yapakati yamanjenje (CNS) lymphoma ndi matenda omwe ma cell oyipa (khansa) amapangidwa m'mitsempha ya ubongo ndi / kapena msana.

• Kukhala ndi chitetezo chamthupi chofooka kumatha kuwonjezera chiopsezo chokhala ndi CNS lymphoma yoyamba.

• Mayeso omwe amayesa maso, ubongo, ndi msana amagwiritsidwa ntchito kuti apeze (kupeza) ndikuzindikira CNS lymphoma yoyamba.

• Zinthu zina zimakhudzanso madandaulo (mwayi wochira) ndi njira zamankhwala.

Njira yapakati yapakati yamanjenje (CNS) lymphoma ndi matenda omwe ma cell oyipa (khansa) amapangidwa m'mitsempha ya ubongo ndi / kapena msana.

Lymphoma ndi matenda omwe mumakhala maselo owopsa (khansa) am'mimba. Mitsempha ya m'thupi ndi mbali ya chitetezo cha mthupi ndipo imakhala ndi ma lymph, ma lymph lymph, ma lymph node, spleen, thymus, tonsils, ndi mafupa. Ma lymphocyte (omwe amakhala mumimba) amayenda ndikutuluka mkati mwa dongosolo lamanjenje (CNS). Amakhulupirira kuti ena mwa ma lymphocyte amayamba kukhala owopsa ndikupangitsa kuti lymphoma ipangidwe mu CNS. Pulayimale CNS lymphoma imatha kuyambira muubongo, msana, kapena meninges (zigawo zomwe zimaphimba kunja kwa ubongo). Chifukwa diso lili pafupi kwambiri ndi ubongo, CNS lymphoma yoyamba imatha kuyambiranso m'maso (yotchedwa ocular lymphoma).

Anatomy of the lymph system, yowonetsa ziwiya zam'mimba ndi ziwalo zam'mimba kuphatikiza ma lymph node, matonil, thymus, ndulu, ndi mafupa. Lymph (clear fluid) ndi ma lymphocyte amayenda kudzera mumitsempha yam'mimba ndikupita kumalo am'mimba momwe ma lymphocyte amawonongera zinthu zowopsa. Nthiti imalowa m'magazi kudzera mumitsempha yayikulu pafupi ndi mtima.

Kukhala ndi chitetezo chamthupi chofooka kumatha kuwonjezera chiopsezo chokhala ndi CNS lymphoma yoyamba.

Chilichonse chomwe chimakulitsa mwayi wanu wodwala chimatchedwa chiopsezo. Kukhala ndi chiwopsezo sikutanthauza kuti udzakhala ndi khansa; kusakhala ndi zoopsa sikutanthauza kuti simudzakhala ndi khansa. Lankhulani ndi dokotala ngati mukuganiza kuti mutha kukhala pachiwopsezo.

Pulayimale ya CNS lymphoma imatha kupezeka kwa odwala omwe atenga matenda a immunodeficiency syndrome (AIDS) kapena matenda ena amthupi kapena omwe adalowetsa impso. Kuti mumve zambiri za lymphoma mwa odwala AIDS, onani chidule cha chokhudzana ndi Edzi Yokhudzana ndi Lymphoma Treatment.

Mayeso omwe amayesa maso, ubongo, ndi msana amagwiritsidwa ntchito kuti apeze (kupeza) ndikuzindikira CNS lymphoma yoyamba.

Mayeso ndi njira zotsatirazi zitha kugwiritsidwa ntchito:

• Kuwunika kwakuthupi ndi mbiri: Kuyesedwa kwa thupi kuti muwone zizindikiritso zaumoyo, kuphatikiza kuyang'ana ngati pali matenda, monga zotupa kapena china chilichonse chomwe chikuwoneka chachilendo. Mbiri yokhudzana ndi thanzi la wodwalayo komanso matenda am'mbuyomu komanso chithandizo chamankhwala adzachitidwanso.

• Kuyesa kwamitsempha: Mafunso ndi mayeso angapo owunika ubongo, msana, ndi kugwira ntchito kwa mitsempha. Mayesowa amawunika momwe munthu amaganizira, momwe amagwirira ntchito, momwe angathere kuyenda moyenera, komanso momwe minofu, mphamvu, ndi malingaliro zimagwirira ntchito. Izi amathanso kutchedwa mayeso a neuro kapena mayeso a neurologic.

• Kuyesa diso la nyali: Kuyesa komwe kumagwiritsa ntchito maikulosikopu yapadera yokhala ndi kuwala kowala, kopapatiza kuti muwone kunja ndi mkati mwa diso.

• MRI (magnetic resonance imaging): Njira yomwe imagwiritsa ntchito maginito, mafunde a wailesi, ndi kompyuta kuti ipange zithunzi zingapo zamalo amkati mwaubongo ndi msana. Chinthu chotchedwa gadolinium chimalowetsedwa mwa wodwalayo kudzera mu mtsempha. Gadolinium imasonkhanitsa mozungulira maselo a khansa kuti athe kuwonekera pachithunzichi. Njirayi imatchedwanso nuclear magnetic resonance imaging (NMRI).

• PET scan (positron emission tomography scan): Njira yopezera maselo oyipa mthupi. Gulu laling'ono la shuga (radio) limabayidwa mumtsempha. Chojambulira cha PET chimazungulira thupi ndikupanga chithunzi cha komwe glucose imagwiritsidwa ntchito mthupi. Maselo otupa owopsa amawonekera pachithunzichi chifukwa amakhala otanganidwa ndipo amatenga shuga wambiri kuposa momwe maselo amachitira.

• Lumbar puncture: Njira yogwiritsira ntchito cerebrospinal fluid (CSF) kuchokera pamtsempha. Izi zimachitika poika singano pakati pa mafupa awiri mumsana ndi CSF mozungulira msana ndikuchotsa madzi. Chitsanzo cha CSF chimayang'aniridwa ndi microscope ngati pali zotupa. Zitsanzozo zitha kuwunikiranso kuchuluka kwa mapuloteni ndi shuga. Kuchuluka kwa mapuloteni ocheperako kapena kutsika kwa shuga kungakhale chizindikiro cha chotupa. Njirayi imatchedwanso LP kapena tapu ya msana.

Lumbar kuboola. Wodwala amagona pamalo okuta patebulo. Dera laling'ono kumunsi kumapeto kwake, dzenje la msana (singano yayitali, yopyapyala) imalowetsedwa m'munsi mwa msana kuti muchotse madzi amadzimadzi (CSF, omwe akuwonetsedwa ndi buluu). Timadzimadzi timatumizidwa ku labotale kukayezetsa.

• Stereotactic biopsy: Ndondomeko yoyeserera yomwe imagwiritsa ntchito kompyuta ndi chida chojambulira cha 3-dimensional (3-D) kuti ipeze chotupa ndikuwongolera kuchotsa kwa minofu kuti izitha kuwonedwa ndi microscope kuti muwone ngati pali khansa.

Mayeso otsatirawa atha kuchitika pazitsanzo za minofu yomwe yachotsedwa:

• Flow cytometry: Kuyesa kwa labotale komwe kumayeza kuchuluka kwa maselo munzitsanzo, kuchuluka kwa maselo amoyo pachitsanzo, ndi mawonekedwe ena amamaselo, monga kukula, mawonekedwe, ndi kupezeka kwa zotupa (kapena zina) pamwamba pa khungu. Maselo ochokera pagazi la wodwalayo, m'mafupa, kapena minofu ina amadetsedwa ndi utoto wa fulorosenti, amaikidwa mumadzimadzi, kenako nkuwudutsa kamodzi mwa kuwala. Zotsatira zakuyesa zimadalira momwe maselo omwe adadetsedwa ndi utoto wa fluorescent amatengera kuwala kwa kuwala. Mayesowa amagwiritsidwa ntchito kuthandizira kuzindikira ndi kusamalira mitundu ina ya khansa, monga khansa ya m'magazi ndi lymphoma.

• Immunohistochemistry: Kuyesa kwa labotale komwe kumagwiritsa ntchito ma antibodies kuti aone ngati ali ndi ma antigen (zolembera) muzitsanzo za minofu ya wodwala. Ma antibodies nthawi zambiri amalumikizidwa ndi enzyme kapena utoto wa fulorosenti. Ma antibodies atagwirizana ndi antigen inayake munthawi ya minofu, enzyme kapena utoto umayambitsidwa, ndipo antigen imatha kuwonedwa ndi microscope. Mayeso amtunduwu amagwiritsidwa ntchito pothandiza kuzindikira khansa ndikuthandizira kudziwa khansa yamtundu wina wa khansa.

• Kusanthula kwa cytogenetic: Kuyesa kwa labotale komwe ma chromosomes am'magazi am'magazi kapena m'mafupa amawerengedwa ndikuwunika ngati pali kusintha kulikonse, monga ma chromosomes osweka, osowa, okonzedwanso kapena owonjezera. Kusintha kwa ma chromosomes ena kungakhale chizindikiro cha khansa. Kusanthula kwa cytogenetic kumagwiritsidwa ntchito kuthandizira kuzindikira khansa, kukonzekera chithandizo, kapena kudziwa momwe chithandizo chikuyendera.

• FISH (fluorescence in situ hybridization): Kuyesa kwa labotale komwe kumayang'ana ndikuwerengera majini kapena ma chromosomes m'maselo ndi minofu. Zidutswa za DNA zomwe zimakhala ndi utoto wa fulorosenti zimapangidwa mu labotale ndikuwonjezeredwa muzitsanzo zamaselo a wodwalayo. Zidutswa za DNA zoterezi zikalumikizana ndi majini kapena madera ena a chromosomes mchitsanzo, zimawala zikawonedwa ndi microscope ya fulorosenti. Kuyesa kwa FISH kumagwiritsidwa ntchito kuthandizira kuzindikira khansa ndikuthandizira kukonzekera mankhwala.

• Kuwerengera kwathunthu kwa magazi (CBC) mosiyanasiyana: Njira yomwe magazi amatengedwa ndikuwunika zotsatirazi:

• Chiwerengero cha maselo ofiira ndi ma platelet.

• Chiwerengero ndi mtundu wama cell oyera.

• Kuchuluka kwa hemoglobin (puloteni yomwe imanyamula mpweya) m'maselo ofiira amwazi.

• Gawo la magazi lomwe limapangidwa ndi maselo ofiira.

Kuwerengera kwathunthu kwa magazi (CBC). Magazi amatengedwa polowetsa singano mumtsempha ndikuloleza magazi kuti alowe mu chubu. Sampulo yamwazi imatumizidwa ku labotale ndipo maselo ofiira amwazi, maselo oyera amwazi, ndi ma platelet amawerengedwa. CBC imagwiritsidwa ntchito kuyesa, kuzindikira, ndikuwunika zochitika zosiyanasiyana.

• Kafukufuku wamagazi: Njira yoyeserera magazi kuti ayese kuchuluka kwa zinthu zina zomwe zimatulutsidwa m'magazi ndi ziwalo ndi minyewa mthupi. Kuchuluka kwazinthu zosazolowereka (zakumwamba kapena zochepa) kungakhale chizindikiro cha matenda.

Zinthu zina zimakhudzanso madandaulo (mwayi wochira) ndi njira zamankhwala.

Kulosera (mwayi wochira) zimatengera izi:

• Msinkhu wa wodwalayo komanso thanzi lake lonse.

• Mulingo wa zinthu zina m'magazi ndi cerebrospinal fluid (CSF).

• Kumene chotupacho chili mkatikati mwa manjenje, diso, kapena zonse ziwiri.

• Kaya wodwalayo ali ndi Edzi.

Njira zochiritsira zimadalira izi:

• Gawo la khansa.

• Kumene chotupacho chili mkatikati mwa manjenje.

• Msinkhu wa wodwalayo komanso thanzi lake lonse.

• Kaya khansa yapezeka kumene kapena yabwereranso (bwererani).

Chithandizo cha CNS lymphoma chimagwira ntchito bwino ngati chotupacho sichinafalikire kunja kwa ubongo (gawo lalikulu kwambiri muubongo) ndipo wodwalayo ndi wochepera zaka 60, amatha kuchita zambiri tsiku lililonse, ndipo alibe Edzi kapena matenda ena omwe kufooketsa chitetezo chamthupi.

Makina Oyambira a CNS Lymphoma

MFUNDO ZOFUNIKA

• Pambuyo pamagulu oyambira amanjenje (CNS) lymphoma atapezeka, amayesedwa kuti apeze ngati maselo a khansa afalikira mkati mwaubongo ndi msana kapena mbali zina za thupi.

• Pali njira zitatu zomwe khansa imafalikira mthupi.

• Khansa imatha kufalikira pomwe idayamba kupita mbali zina za thupi.

• Palibe njira yokhazikika yoyambira CNS lymphoma.

Pambuyo pamagulu oyambira amanjenje (CNS) lymphoma atapezeka, amayesedwa kuti apeze ngati maselo a khansa afalikira mkati mwaubongo ndi msana kapena mbali zina za thupi.

CNS lymphoma yoyamba ikakulirakulira, nthawi zambiri siyimafalikira kupitirira dongosolo lamanjenje kapena diso. Njira yomwe imagwiritsidwa ntchito pofufuza ngati khansa yayamba kutchedwa staging. Ndikofunika kudziwa ngati khansara yafalikira mbali zina za thupi kuti mukonzekere chithandizo. Mayeso ndi njira zotsatirazi zitha kugwiritsidwa ntchito pokonza:

• CT scan (CAT scan): Njira yomwe imapanga zithunzi zingapo zamatupi amthupi, zojambulidwa mosiyanasiyana. Zithunzizo zimapangidwa ndi kompyuta yolumikizidwa ndi makina a x-ray. Utoto ukhoza kulowetsedwa mumtsempha kapena kumeza kuti ziwalo kapena ziwalo ziwoneke bwino. Njirayi imatchedwanso computed tomography, kompyuta tomography, kapena kompyuta axial tomography. Kwa CNS lymphoma yoyamba, CT scan imachitika pachifuwa, pamimba, ndi m'chiuno (gawo la thupi pakati pa ntchafu).

• PET scan (positron emission tomography scan): Njira yopezera maselo oyipa mthupi. Gulu laling'ono la shuga (radio) limabayidwa mumtsempha. Chojambulira cha PET chimazungulira thupi ndikupanga chithunzi cha komwe glucose imagwiritsidwa ntchito mthupi. Maselo otupa owopsa amawonekera pachithunzichi chifukwa amakhala otanganidwa ndipo amatenga shuga wambiri kuposa momwe maselo amachitira. PET scan ndi CT scan zitha kuchitika nthawi yomweyo. Izi zimatchedwa PET-CT.

• MRI (magnetic resonance imaging): Njira yomwe imagwiritsa ntchito maginito, mafunde a wailesi, ndi kompyuta kuti ipange zithunzi zingapo za malo amkati mwa thupi. Njirayi imatchedwanso nuclear magnetic resonance imaging (NMRI).

• Kulakalaka kwa mafuta m'mafupa ndi biopsy: Kuchotsa mafupa, magazi, ndi kachigawo kakang'ono ka fupa poika singano yopanda kanthu m'chiuno kapena m'chifuwa. Dokotala akuwona mafupa, magazi, ndi mafupa pansi pa microscope kuti ayang'ane zizindikiro za khansa.

Kukhumba kwamfupa ndi mafupa. Gawo laling'ono la khungu litachita dzanzi, singano ya m'mafupa imalowetsedwa m'fupa la m'chiuno la wodwalayo. Zitsanzo zamagazi, mafupa, ndi mafupa amachotsedwa kuti zikaunikidwe ndi microscope.

Pali njira zitatu zomwe khansa imafalikira mthupi.

Khansa imatha kufalikira kudzera mu minofu, ma lymph system, ndi magazi:

• Minofu. Khansara imafalikira kuchokera pomwe idayamba ndikukula kupita kumadera oyandikana nawo.

• Lymph dongosolo. Khansara imafalikira kuchokera pomwe idayamba polowa m'mitsempha. Khansara imadutsa m'mitsempha yamafuta kupita mbali zina za thupi.

• Magazi. Khansara imafalikira kuchokera pomwe idayamba ndikulowa m'magazi. Khansara imadutsa m'mitsempha yamagazi kupita mbali zina za thupi.

Khansa imatha kufalikira pomwe idayamba kupita mbali zina za thupi.

Khansa ikafalikira mbali ina ya thupi, imatchedwa metastasis. Maselo a khansa amachoka pomwe adayamba (chotupa choyambirira) ndikuyenda mumitsempha kapena magazi.

• Lymph dongosolo. Khansara imalowa mumitsempha, imadutsa m'mitsempha yamafuta, ndikupanga chotupa (chotupa cha metastatic) gawo lina la thupi.

• Magazi. Khansara imalowa m'magazi, imadutsa m'mitsempha yamagazi, ndikupanga chotupa (chotupa cha metastatic) gawo lina la thupi.

Chotupa cha metastatic ndi khansa yofanana ndi chotupa chachikulu. Mwachitsanzo, ngati CNS lymphoma yoyamba imafalikira m'chiwindi, maselo a khansa m'chiwindi ndi ma lymphoma. Matendawa ndi metastatic CNS lymphoma, osati khansa ya chiwindi.

Palibe njira yokhazikika yoyambira CNS lymphoma.

Kubwereza Pulayimale CNS Lymphoma

Njira yaposachedwa yapakatikati yamanjenje (CNS) lymphoma ndi khansa yomwe yabwereranso (kubwerera) itachiritsidwa. Pulayimale CNS lymphoma imakonda kubwereranso muubongo kapena m'maso.

Chithandizo Chosankha Mwachidule

MFUNDO ZOFUNIKA

• Pali mitundu yosiyanasiyana ya chithandizo cha odwala omwe ali ndi CNS lymphoma.

• Mankhwala atatu omwe amagwiritsidwa ntchito amagwiritsidwa ntchito:

• Thandizo la radiation

• Chemotherapy

• Steroid mankhwala

• Mitundu yatsopano yamankhwala ikuyesedwa m'mayesero azachipatala.

• Chemotherapy yamphamvu kwambiri yokhala ndi tsinde lama cell

• Chithandizo chofuna

• Chithandizo cha CNS lymphoma choyambirira chingayambitse zovuta.

• Odwala angaganize zopita nawo kukayezetsa.

• Odwala amatha kulowa m'mayesero azachipatala asanayambe, asanayambe, kapena atayamba kulandira chithandizo cha khansa.

• Mayeso otsatirawa angafunike.

Pali mitundu yosiyanasiyana ya chithandizo cha odwala omwe ali ndi CNS lymphoma.

Pali mitundu ingapo yamankhwala othandizira odwala omwe ali ndi vuto loyambira (CNS) lymphoma. Mankhwala ena ndi ofanana (mankhwala omwe akugwiritsidwa ntchito pano), ndipo ena akuyesedwa m'mayesero azachipatala. Kuyesedwa kwachipatala ndi kafukufuku wofufuza wothandizira kusintha chithandizo chamakono kapena kupeza zidziwitso zamankhwala atsopano kwa odwala khansa. Pamene mayesero azachipatala awonetsa kuti chithandizo chatsopano ndichabwino kuposa chithandizo chamankhwala, chithandizocho chitha kukhala chamankhwala wamba. Odwala angaganize zopita nawo kukayezetsa. Mayesero ena azachipatala ndi otseguka kwa odwala omwe sanayambe kulandira chithandizo.

Opaleshoni sagwiritsidwa ntchito pochizira CNS lymphoma.

Mankhwala atatu omwe amagwiritsidwa ntchito amagwiritsidwa ntchito:

Thandizo la radiation

Thandizo la radiation ndi chithandizo cha khansa chomwe chimagwiritsa ntchito ma x-ray amphamvu kapena mitundu ina ya radiation kuti iphe ma cell a khansa kapena kuti asakule. Pali mitundu iwiri ya mankhwala a radiation:

• Mankhwala ochiritsira akunja amagwiritsa ntchito makina kunja kwa thupi kuti atumize cheza chaku khansa. Chifukwa CNS lymphoma yoyamba imafalikira muubongo, mankhwala amtundu wakunja amaperekedwa kuubongo wonse. Izi zimatchedwa mankhwala amtundu waubongo wathunthu.

• Njira yothandizira poizoniyu yamkati imagwiritsa ntchito mankhwala a radioactive otsekedwa ndi singano, njere, mawaya, kapena ma catheters omwe amayikidwa mwachindunji kapena pafupi ndi khansa.

Momwe mankhwalawa amaperekedwera zimadalira ngati wodwalayo ali ndi CNS lymphoma ndi AIDS. Thandizo la radiation lakunja limagwiritsidwa ntchito pochizira CNS lymphoma yoyamba.

Chithandizo champhamvu kwambiri cha radiation kuubongo chitha kuwononga minofu yabwinobwino ndikupangitsa zovuta zomwe zingakhudze kuganiza, kuphunzira, kuthetsa mavuto, kulankhula, kuwerenga, kulemba, komanso kukumbukira. Kuyesedwa kwachipatala kwayesa kugwiritsa ntchito chemotherapy yokha kapena mankhwala asanafike pochotsa ma radiation kuti achepetse kuwonongeka kwa minofu yabwinobwino ya ubongo yomwe imachitika pogwiritsa ntchito mankhwala a radiation.

Chemotherapy

Chemotherapy ndi mankhwala a khansa omwe amagwiritsa ntchito mankhwala oletsa kukula kwa maselo a khansa, mwina popha ma cell kapena kuwaletsa kuti asagawane. Chemotherapy ikamamwa pakamwa kapena kulowetsedwa mumtsempha kapena minofu, mankhwalawa amalowa m'magazi ndipo amatha kufikira ma cell a khansa mthupi lonse (systemic chemotherapy). Chemotherapy ikaikidwa molunjika mu cerebrospinal fluid (intrathecal chemotherapy), chiwalo, kapena thupi monga pamimba, mankhwalawa amakhudza kwambiri ma cell a khansa m'malo amenewo (chemotherapy am'madera).

Momwe chemotherapy imaperekedwa imadalira komwe chotupacho chili mu CNS kapena diso. Pulayimale CNS lymphoma itha kuchiritsidwa ndi systemic chemotherapy, intrathecal chemotherapy ndi / kapena intraventricular chemotherapy, momwe mankhwala oletsa khansa amaikidwa mu ma ventricles (minyewa yodzaza madzi) yaubongo. Ngati CNS lymphoma yoyamba imapezeka m'maso, mankhwala opatsirana ndi khansa amabayidwa molunjika mu vitreous humor (chinthu chofanana ndi jelly) mkati mwa diso.

Matenda a chemotherapy. Mankhwala a anticancer amalowetsedwa mu intrathecal space, omwe ndi malo omwe amakhala ndi cerebrospinal fluid (CSF, yowonetsedwa ndi buluu). Pali njira ziwiri zochitira izi. Njira imodzi, yomwe ikuwonetsedwa kumtunda kwa chiwerengerocho, ndi kuyika mankhwalawo mu dziwe la Ommaya (chidebe chowoneka ngati dome chomwe chimayikidwa pansi pamutu pochita opareshoni; imagwira mankhwalawo akamadutsa chubu kakang'ono kupita muubongo ). Njira ina, yomwe ikuwonetsedwa kumapeto kwa chiwerengerocho, ndikulowetsa mankhwalawo mu CSF mmunsi mwa msana, pambuyo poti dera laling'ono kumunsi kwanjenjemera.

Neti yamitsempha yamagazi ndi minofu, yotchedwa chotchinga magazi-ubongo, imateteza ubongo kuzinthu zoyipa. Chotchinga ichi chimathandizanso kuti mankhwala oletsa khansa asafike kuubongo. Pofuna kuchiza CNS lymphoma, mankhwala ena angagwiritsidwe ntchito kutsegula pakati pa maselo otchinga magazi-ubongo. Izi zimatchedwa kusokonezeka kwa zotchinga magazi. Mankhwala opatsirana pogonana omwe amalowetsedwa m'magazi amatha kufikira muubongo.

Steroid mankhwala

Steroids ndi mahomoni opangidwa mwachilengedwe mthupi. Zitha kupangidwanso mu labotale ndikugwiritsidwa ntchito ngati mankhwala. Glucocorticoids ndi mankhwala a steroid omwe ali ndi vuto la anticancer m'matenda am'magazi.

Mitundu yatsopano yamankhwala ikuyesedwa m'mayesero azachipatala.

Gawo lachiduleli likufotokoza zamankhwala omwe akuwerengedwa m'mayesero azachipatala. Sizingatchule chithandizo chilichonse chatsopano chomwe akuphunzira. Zambiri zamayeso azachipatala zimapezeka patsamba la NCI.

Chemotherapy yamphamvu kwambiri yokhala ndi tsinde lama cell

Mlingo waukulu wa chemotherapy umaperekedwa kuti uphe ma cell a khansa. Maselo athanzi, kuphatikiza maselo opanga magazi, nawonso amawonongedwa ndi chithandizo cha khansa. Kuika timitengo tating'onoting'ono ndi chithandizo m'malo mwa maselo omwe amapanga magazi. Maselo otchedwa stem cells (maselo a magazi osakhwima) amachotsedwa m'magazi kapena m'mafupa a wodwalayo kapena woperekayo ndipo amaundana ndi kusungidwa. Wodwalayo akamaliza chemotherapy, maselo osungidwa amasungunuka ndikubwezeretsedwanso mwa kulowetsedwa. Maselo amtundu wobwezeretsansowa amakula (ndikubwezeretsanso) maselo amthupi.

Chithandizo chofuna

Chithandizo choyenera ndi mtundu wa chithandizo chomwe chimagwiritsa ntchito mankhwala osokoneza bongo kapena zinthu zina kuti ziwononge maselo a khansa. Njira zochiritsira zomwe zimayang'aniridwa sizimavulaza maselo wamba kuposa chemotherapy kapena radiation. Mankhwala a monoclonal antibody ndi mtundu umodzi wa mankhwala omwe amaphunzitsidwa pochiza CNS lymphoma.

Mankhwala a monoclonal antibody ndi mankhwala a khansa omwe amagwiritsa ntchito ma antibodies opangidwa mu labotale kuchokera ku mtundu umodzi wamthupi. Ma antibodies awa amatha kuzindikira zinthu zomwe zili m'maselo a khansa kapena zinthu zabwinobwino zomwe zingathandize ma cell a khansa kukula. Ma antibodies amalumikizana ndi zinthuzo ndikupha ma cell a khansa, amalepheretsa kukula kwawo, kapena amalepheretsa kufalikira. Ma antibodies a monoclonal amaperekedwa mwa kulowetsedwa. Angagwiritsidwe ntchito okha kapena kunyamula mankhwala osokoneza bongo, poizoni, kapena zinthu zowononga radio kupita kuma cell a khansa. Rituximab ndi mtundu wa anti-monoclonal antibody yomwe imagwiritsidwa ntchito pochizira CNS lymphoma mwa omwe alibe AIDS.

Chithandizo cha CNS lymphoma choyambirira chingayambitse zovuta.

Kuti mumve zambiri zamankhwala obwera chifukwa cha khansa, onani tsamba lathu la Zotsatira Zotsatira.

Odwala angaganize zopita nawo kukayezetsa.

Kwa odwala ena, kutenga nawo mbali pakuyesa chithandizo chachipatala kungakhale njira yabwino kwambiri yothandizira. Mayesero azachipatala ndi gawo limodzi la kafukufuku wa khansa. Mayesero azachipatala amachitika kuti apeze ngati mankhwala atsopano a khansa ndi otetezeka komanso ogwira ntchito kapena abwinoko kuposa mankhwala wamba.

Njira zambiri zamankhwala zochiritsira khansa zimachokera kumayeso am'mbuyomu azachipatala. Odwala omwe amatenga nawo mbali pachipatala atha kulandira chithandizo chofananira kapena kukhala oyamba kulandira chithandizo chatsopano.

Odwala omwe amatenga nawo mbali pazoyeserera zamankhwala amathandizanso kukonza momwe khansa idzathandizire mtsogolo. Ngakhale mayesero azachipatala satsogolera kuchipatala chatsopano, nthawi zambiri amayankha mafunso ofunikira ndikuthandizira kupititsa patsogolo kafukufuku.

Odwala amatha kulowa m'mayesero azachipatala asanayambe, asanayambe, kapena atayamba kulandira chithandizo cha khansa.

Mayesero ena azachipatala amangophatikizapo odwala omwe sanalandire chithandizo. Mayesero ena amayesa chithandizo kwa odwala omwe khansa yawo sinakhale bwino. Palinso mayesero azachipatala omwe amayesa njira zatsopano zothetsera khansa kuti isabwererenso (kubwerera) kapena kuchepetsa zovuta zoyambitsidwa ndi khansa.

Mayesero azachipatala akuchitika m'malo ambiri mdziko muno. Zambiri zamayeso azachipatala othandizidwa ndi NCI zitha kupezeka patsamba lofufuza zamankhwala la NCI. Mayesero azachipatala othandizidwa ndi mabungwe ena amapezeka patsamba la ClinicalTrials.gov.

Mayeso otsatirawa angafunike.

Ena mwa mayesero omwe adachitika kuti apeze khansa kapena kuti adziwe momwe khansa iliri angabwerezedwenso. Mayesero ena adzabwerezedwa kuti awone momwe mankhwalawa akugwirira ntchito. Zisankho zakuti mupitilize, kusintha, kapena kusiya kulandira chithandizo zitha kutengera zotsatira za mayeso awa.

Kuyesaku kumangopitilira kuchitika nthawi ndi nthawi mankhwala atatha. Zotsatira zamayesowa zitha kuwonetsa ngati vuto lanu lasintha kapena ngati khansa yabwereranso (bwererani). Mayesowa nthawi zina amatchedwa kuyesa kutsata kapena kukayezetsa.

Njira Zothandizira Kuchiza kwa CNS Lymphoma

M'chigawo chino

• Pulayimale CNS Lymphoma

• Lymphoma Yoyamba Kwambiri

• Kubwereza Pulayimale CNS Lymphoma

Kuti mumve zambiri zamankhwala omwe atchulidwa pansipa, onani gawo la Chisankho Chachidule.

Pulayimale CNS Lymphoma

Chithandizo cha primary central nervous system (CNS) lymphoma chingaphatikizepo izi:

• Thandizo lonse la radiation.

• Chemotherapy.

• Chemotherapy yotsatira ndi radiation radiation.

• Chemotherapy and targeted therapy (rituximab) yotsatiridwa ndi chemotherapy yayikulu komanso kuponyera ma cell a stem.

• Kuyesedwa kwachipatala kwa chemotherapy yayikulu ndi kuponyera ma cell a stem.

• Kuyesedwa kwachipatala kwa chemotherapy yayikulu komanso mankhwala omwe amalimbana nawo (rituximab), okhala ndi kapena opanda cell cell kapena mankhwala onse a radiation.

Lymphoma Yoyamba Kwambiri

Chithandizo cha primary intraocular lymphoma chingaphatikizepo izi:

• Chemotherapy (intraocular kapena systemic).

• Thandizo lonse la radiation.

Kubwereza Pulayimale CNS Lymphoma

Chithandizo cha njira yapakatikati yamanjenje (CNS) lymphoma chingaphatikizepo izi:

• Chemotherapy.

• Thandizo la radiation (ngati silinalandire chithandizo choyambirira).

• Kuyesedwa kwachipatala kwa mankhwala atsopano kapena ndandanda ya chithandizo.

Gwiritsani ntchito kusaka kwathu kwamankhwala kuti mupeze mayesero azachipatala omwe amathandizidwa ndi NCI omwe akulandira odwala. Mutha kusaka mayesero kutengera mtundu wa khansa, zaka za wodwalayo, komanso komwe mayeserowo akuchitika. Zambiri pazokhudza mayesero azachipatala zimapezekanso.

Kuti mudziwe zambiri za CNS Lymphoma

Kuti mumve zambiri kuchokera ku National Cancer Institute yokhudza CNS lymphoma yoyamba, onani izi:

• Tsamba Lymphoma Tsamba

Kuti mumve zambiri za khansa ndi zinthu zina zochokera ku National Cancer Institute, onani izi:

• Za Khansa

• Kusinthana

• Chemotherapy and You: Kuthandiza Anthu Omwe Ali Ndi Khansa

• Thandizo la Radiation ndi Inu: Thandizo kwa Anthu Omwe Ali ndi Khansa

• Kulimbana ndi khansa

• Mafunso oti mufunse dokotala wanu za khansa

• Kwa Opulumuka ndi Owasamalira