Mitundu / langerhans / wodwala / langerhans-chithandizo-pdq

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Chithandizo cha Langerhans Cell Histiocytosis (®) -Patient Version

Zambiri Zokhudza Langerhans Cell Histiocytosis (LCH)

MFUNDO ZOFUNIKA

  • Langerhans cell histiocytosis ndi mtundu wa khansa yomwe imatha kuwononga minofu kapena kupangitsa zilonda kupanga malo amodzi kapena angapo mthupi.
  • Mbiri ya banja la khansa kapena kukhala ndi kholo lomwe lidakumana ndi mankhwala ena kumatha kuwonjezera ngozi ya LCH.
  • Zizindikiro za LCH zimadalira komwe kuli mthupi.
  • Khungu ndi misomali
  • Pakamwa
  • Fupa
  • Matenda am'mimba ndi thymus
  • Endocrine dongosolo
  • Diso
  • Mchitidwe wamanjenje wapakati (CNS)
  • Chiwindi ndi ndulu
  • Mapapo
  • M'mafupa
  • Kuyesa komwe kumayang'ana ziwalo ndi machitidwe amthupi komwe LCH imatha kuchitika amagwiritsidwa ntchito pozindikira LCH.
  • Zinthu zina zimakhudzanso madandaulo (mwayi wochira) ndi njira zamankhwala.

Langerhans cell histiocytosis ndi mtundu wa khansa yomwe imatha kuwononga minofu kapena kupangitsa zilonda kupanga malo amodzi kapena angapo mthupi.

Langerhans cell histiocytosis (LCH) ndi khansa yosowa yomwe imayamba m'maselo a LCH. Maselo a LCH ndi mtundu wa cell dendritic womwe umalimbana ndi matenda. Nthawi zina pamakhala masinthidwe (kusintha) m'maselo a LCH momwe amapangidwira. Izi zikuphatikiza kusintha kwa majini a BRAF, MAP2K1, RAS ndi ARAF. Kusintha kumeneku kumatha kupangitsa kuti maselo a LCH akule ndikuchulukirachulukira mwachangu. Izi zimapangitsa kuti ma LCH amange m'magulu ena amthupi, momwe amatha kuwononga minofu kapena kupanga zotupa.

LCH si matenda am'maselo a Langerhans omwe amapezeka pakhungu.

LCH imatha kuchitika nthawi iliyonse, koma imafala kwambiri kwa ana aang'ono. Chithandizo cha LCH mwa ana ndi chosiyana ndi chithandizo cha LCH mwa akulu. Chithandizo cha LCH mwa ana ndi chithandizo cha LCH mwa akulu chimafotokozedwa m'magawo osiyana achidule.

Mbiri ya banja la khansa kapena kukhala ndi kholo lomwe lidakumana ndi mankhwala ena kumatha kuwonjezera ngozi ya LCH.

Chilichonse chomwe chimakulitsa chiopsezo chotenga matenda chimatchedwa chiopsezo. Kukhala ndi chiwopsezo sikutanthauza kuti udzakhala ndi khansa; kusakhala ndi zoopsa sikutanthauza kuti simudzakhala ndi khansa. Lankhulani ndi dokotala ngati mukuganiza kuti mutha kukhala pachiwopsezo.

Zowopsa za LCH ndi izi:

  • Kukhala ndi kholo lomwe limakumana ndi mankhwala enaake.
  • Kukhala ndi kholo lomwe limayang'aniridwa ndi chitsulo, granite, kapena fumbi lamatabwa kuntchito.
  • Mbiri ya khansa, kuphatikiza LCH.
  • Kukhala ndi mbiri yakale kapena mbiri yamabanja yamatenda a chithokomiro.
  • Kukhala ndi matenda ngati mwana wakhanda.
  • Kusuta, makamaka kwa achinyamata.
  • Kukhala ku Puerto Rico.
  • Osalandira katemera ali mwana.

Zizindikiro za LCH zimadalira komwe kuli mthupi.

Izi ndi zizindikilo ndi zina zimatha kuyambitsidwa ndi LCH kapena zina. Funsani dokotala wanu ngati inu kapena mwana wanu muli ndi zotsatirazi:

Khungu ndi misomali

LCH mwa ana imatha kukhudza khungu lokha. Nthawi zina, khungu lokha LCH limatha kuwonjezeka patadutsa milungu kapena miyezi ndipo limakhala mawonekedwe otchedwa LCH.

Kwa makanda, zizindikilo za LCH zomwe zimakhudza khungu zimatha kukhala:

  • Kuphulika kwa khungu komwe kumatha kuwoneka ngati "kapu ya kubadwa".
  • Kukula m'matupi amthupi, monga chigongono chamkati kapena perineum.
  • Khungu lotuluka, lofiirira kapena lofiirira paliponse pathupi.

Kwa ana ndi akulu, zizindikiro za LCH zomwe zimakhudza khungu ndi misomali zitha kukhala izi:

  • Kuphulika kwa khungu komwe kumatha kuwoneka ngati dandruff.
  • Kukula kofiira, kofiira kapena kofiirira, kotupa m'mimba, pamimba, kumbuyo, kapena pachifuwa, komwe kumatha kuyabwa kapena kupweteka.
  • Ziphuphu kapena zilonda pamutu.
  • Zilonda kuseri kwa makutu, pansi pa mabere, kapena m'malo am'mimba.
  • Zikhadabo zomwe zimagwa kapena zokhala ndi mabala otumbululuka omwe amathamangira msomali.

Pakamwa

Zizindikiro za LCH zomwe zimakhudza pakamwa zimatha kuphatikiza:

  • Kutupa m'kamwa.
  • Zilonda padenga pakamwa, mkati mwa masaya, kapena lilime kapena milomo.

Mano omwe amakhala osagwirizana kapena kutuluka.

Fupa

Zizindikiro za LCH zomwe zimakhudza fupa zingaphatikizepo:

  • Kutupa kapena chotupa pamwamba pa fupa, monga chigaza, nsagwada, nthiti, mafupa a chiuno, msana, fupa la ntchafu, fupa lakumtunda, chigongono, bowo lamaso, kapena mafupa ozungulira khutu.
  • Kupweteka kumene kuli kutupa kapena chotupa pamwamba pa fupa.

Ana omwe ali ndi zotupa za LCH m'mafupa ozungulira makutu kapena maso ali pachiwopsezo chachikulu cha matenda a shuga insipidus ndi matenda ena apakati amanjenje.

Matenda am'mimba ndi thymus

Zizindikiro za LCH zomwe zimakhudza ma lymph node kapena thymus zitha kuphatikizira izi:

  • Kutupa ma lymph node.
  • Kuvuta kupuma.
  • Matenda apamwamba a vena cava. Izi zimatha kuyambitsa kutsokomola, kupuma movutikira, ndi kutupa kwa nkhope, khosi, ndi mikono yakumtunda.

Endocrine dongosolo

Zizindikiro za LCH zomwe zimakhudza vuto la pituitary zimatha kuphatikiza:

  • Matenda a shuga. Izi zitha kuyambitsa ludzu komanso kukodza pafupipafupi.
  • Kukula pang'onopang'ono.
  • Kutha msinkhu kapena mochedwa.
  • Kukhala wonenepa kwambiri.

Zizindikiro za LCH zomwe zimakhudza chithokomiro zimatha kukhala:

  • Kutupa chithokomiro.
  • Matenda osokoneza bongo. Izi zitha kuyambitsa kutopa, kusowa mphamvu, kukhala ozindikira kuzizira, kudzimbidwa, khungu louma, kupatulira tsitsi, mavuto akumbukiro, kuvuta kuganizira, komanso kukhumudwa. Kwa makanda, izi zimathandizanso kuti munthu asakhale ndi chilakolako chofuna kudya komanso kuti asamadye chakudya. Kwa ana ndi achinyamata, izi zingayambitsenso mavuto amakhalidwe, kunenepa, kukula pang'onopang'ono, komanso kutha msinkhu.
  • Kuvuta kupuma.

Diso

Zizindikiro za LCH zomwe zimakhudza diso zingaphatikizepo:

  • Mavuto masomphenya.

Mchitidwe wamanjenje wapakati (CNS)

Zizindikiro za LCH zomwe zimakhudza CNS (ubongo ndi msana) zitha kuphatikizira izi:

  • Kutayika bwino, kusayenda bwino kwa thupi, komanso kuyenda movutikira.
  • Kulephera kuyankhula.
  • Kuvuta kuwona.
  • Kupweteka mutu.
  • Zosintha pamakhalidwe kapena umunthu.
  • Mavuto okumbukira.

Zizindikirozi zimatha kuyambitsidwa ndi zotupa mu CNS kapena CNS neurodegenerative syndrome.

Chiwindi ndi ndulu

Zizindikiro za LCH zomwe zimakhudza chiwindi kapena ndulu zingaphatikizepo:

  • Kutupa m'mimba komwe kumayambitsidwa ndimadzimadzi owonjezera.
  • Kuvuta kupuma.
  • Chikasu pakhungu ndi azungu amaso.
  • Kuyabwa.
  • Kuvulaza kosavuta kapena kutuluka magazi.
  • Kumva kutopa kwambiri.

Mapapo

Zizindikiro za LCH zomwe zimakhudza mapapo zimatha kuphatikiza:

  • Mapapu atagwa. Matendawa amatha kupweteka pachifuwa kapena kukanika, kupuma movutikira, kumva kutopa, komanso khungu labuluu pakhungu.
  • Kuvuta kupuma, makamaka achikulire omwe amasuta.
  • Chifuwa chowuma.
  • Kupweteka pachifuwa.

M'mafupa

Zizindikiro za LCH zomwe zimakhudza mafupa amatha kuphatikiza:

  • Kuvulaza kosavuta kapena kutuluka magazi.
  • Malungo.
  • Matenda pafupipafupi.

Kuyesa komwe kumayang'ana ziwalo ndi machitidwe amthupi komwe LCH imatha kuchitika amagwiritsidwa ntchito pozindikira LCH.

Mayesero ndi njira zotsatirazi zitha kugwiritsidwa ntchito kuti mupeze (kupeza) ndikuzindikira LCH kapena zomwe zimayambitsa LCH:

  • Kuyezetsa thupi komanso mbiri yaumoyo: Kuyesedwa kwa thupi kuti muwone zizindikiritso zaumoyo, kuphatikizapo kuyang'ana ngati pali matenda, monga zotupa kapena china chilichonse chomwe chikuwoneka chachilendo. Mbiri yokhudzana ndi thanzi la wodwalayo komanso matenda am'mbuyomu komanso chithandizo chamankhwala adzachitidwanso.
  • Kuyesa kwamitsempha: Mafunso ndi mayeso angapo owunika ubongo, msana, ndi kugwira ntchito kwa mitsempha. Mayesowa amawunika momwe munthu amaganizira, momwe amagwirira ntchito, komanso momwe angayendere bwino, komanso momwe minofu, mphamvu, ndi malingaliro zimagwirira ntchito. Izi amathanso kutchedwa mayeso a neuro kapena mayeso a neurologic.
  • Kuwerengera kwathunthu kwa magazi (CBC) mosiyanasiyana: Njira yomwe magazi amatengedwa ndikuwunika zotsatirazi:
  • Kuchuluka kwa hemoglobin (puloteni yomwe imanyamula mpweya) m'maselo ofiira amwazi.
  • Gawo la magazi lomwe limapangidwa ndi maselo ofiira.
  • Chiwerengero ndi mtundu wama cell oyera.
  • Chiwerengero cha maselo ofiira ndi ma platelet.
  • Kafukufuku wamagazi: Njira yoyeserera magazi kuti ayese kuchuluka kwa zinthu zina zomwe zimatulutsidwa mthupi ndi ziwalo ndi minyewa mthupi. Kuchuluka kwazinthu zosazolowereka (zakumwamba kapena zochepa) kungakhale chizindikiro cha matenda.
  • Kuyesa kwa chiwindi: Kuyesa magazi kuti mupimitse kuchuluka kwamagazi azinthu zina zotulutsidwa ndi chiwindi. Mulingo wokwera kapena wotsika wa zinthuzi ukhoza kukhala chizindikiro cha matenda m'chiwindi.
  • Kuyesedwa kwa majini a BRAF: Kuyesa kwa labotale komwe kuyesa magazi kapena minofu kumayesedwa kuti isinthe mu mtundu wa BRAF.
  • Urinalysis: Kuyesa kuyesa mtundu wa mkodzo ndi zomwe zili mkatimo, monga shuga, mapuloteni, maselo ofiira, ndi maselo oyera amwazi.
  • Kuyesedwa kwamadzi: Kuyesedwa kuti muwone kuchuluka kwa mkodzo komanso ngati umakhudzidwa mukalandira madzi ochepa kapena ayi. Kuyesaku kumagwiritsidwa ntchito pofufuza matenda a shuga insipidus, omwe atha kuyambitsidwa ndi LCH.
  • Kulakalaka kwa mafupa ndi biopsy: Kuchotsa mafupa ndi kachigawo kakang'ono ka fupa poika singano yopanda kanthu m'chiuno. Katswiri wazachipatala amawona mafupa ndi fupa pansi pa microscope kuti ayang'ane zizindikiro za LCH.
Kukhumba kwamfupa ndi mafupa. Gawo laling'ono la khungu litachita dzanzi, singano ya m'mafupa imalowetsedwa m'fupa la m'chiuno la wodwalayo. Zitsanzo zamagazi, mafupa, ndi mafupa amachotsedwa kuti zikaunikidwe ndi microscope.

Mayesero otsatirawa akhoza kuchitika pa minofu yomwe idachotsedwa:

  • Immunohistochemistry: Kuyesa kwa labotale komwe kumagwiritsa ntchito ma antibodies kuti aone ngati ali ndi ma antigen (zolembera) muzitsanzo za minofu ya wodwala. Ma antibodies nthawi zambiri amalumikizidwa ndi enzyme kapena utoto wa fulorosenti. Ma antibodies atagwirizana ndi antigen inayake munthawi ya minofu, enzyme kapena utoto umayambitsidwa, ndipo antigen imatha kuwonedwa ndi microscope. Mayeso amtunduwu amagwiritsidwa ntchito pothandiza kuzindikira khansa ndikuthandizira kudziwa khansa yamtundu wina wa khansa.
  • Flow cytometry: Kuyesa kwa labotale komwe kumayeza kuchuluka kwa maselo munzitsanzo, kuchuluka kwa maselo amoyo pachitsanzo, ndi mawonekedwe ena amamaselo, monga kukula, mawonekedwe, ndi kupezeka kwa zotupa (kapena zina) pamwamba pa khungu. Maselo ochokera pagazi la wodwalayo, m'mafupa, kapena minofu ina amadetsedwa ndi utoto wa fulorosenti, amaikidwa mumadzimadzi, kenako nkuwudutsa kamodzi mwa kuwala. Zotsatira zakuyesa zimadalira momwe maselo omwe adadetsedwa ndi utoto wa fluorescent amatengera kuwala kwa kuwala.
  • Kujambula mafupa: Ndondomeko yowunika ngati pali magawo omwe agawikana mwachangu mufupa. Katundu wocheperako kwambiri wa jakisoni amalowetsedwa mumtsempha ndikuyenda m'magazi. Zinthu zowononga nyukiliya zimasonkhanitsa m'mafupa omwe ali ndi khansa ndipo imadziwika ndi sikani.
Kujambula mafupa. Katundu wambiri wama radio amabayidwa mumitsempha ya mwana ndikuyenda m'magazi. Zinthu zakuthupi zimasonkhanitsa m'mafupa. Mwanayo akugona patebulo lomwe limayenda pansi pa sikani, zida zowulutsa ma radio zimapezeka ndipo zithunzi zimapangidwa pakompyuta.
  • X-ray: X-ray ya ziwalo ndi mafupa mkati mwa thupi. X-ray ndi mtundu wa mphamvu yamphamvu yomwe imatha kupyola thupi ndikupita mufilimu, ndikupanga chithunzi cha madera omwe ali mthupi. Nthawi zina kafukufuku wamafupa amachitika. Imeneyi ndi njira yowunikira x-ray mafupa onse mthupi.
  • CT scan (CAT scan): Njira yomwe imapanga zithunzi zingapo zamatupi amthupi, zojambulidwa mosiyanasiyana. Zithunzizo zimapangidwa ndi kompyuta yolumikizidwa ndi makina a x-ray. Utoto ukhoza kulowetsedwa mumtsempha kapena kumeza kuti ziwalo kapena ziwalo ziwoneke bwino. Njirayi imatchedwanso computed tomography, kompyuta tomography, kapena kompyuta axial tomography.
Kusanthula kwam'mimba kwa kompyuta. Wodwalayo amagona patebulo lomwe limadutsa mu makina a CT, omwe amatenga zithunzi za x-ray zamkati mwa thupi.
  • MRI (magnetic resonance imaging): Njira yomwe imagwiritsa ntchito maginito, mafunde a wailesi, ndi kompyuta kuti ipange zithunzi zingapo za malo amkati mwa thupi. Chinthu chotchedwa gadolinium chitha kulowetsedwa mumtsempha. Gadolinium imasonkhanitsa mozungulira ma cell a LCH kuti iwoneke bwino pachithunzichi. Njirayi imatchedwanso nuclear magnetic resonance imaging (NMRI).
Kujambula kwamaginito (MRI) pamimba. Mwanayo wagona patebulo lomwe limalowa mu sikani ya MRI, yomwe imatenga zithunzi zamkati mwa thupi. Pedi pamimba pamwana limathandizira kuti zithunzizo zizimveka bwino.
  • PET scan (positron emission tomography scan): Njira yopezera zotupa m'thupi. Gulu laling'ono la shuga (radio) limabayidwa mumtsempha. Chojambulira cha PET chimazungulira thupi ndikupanga chithunzi cha komwe glucose imagwiritsidwa ntchito mthupi. Maselo otupa amawonekera bwino pachithunzichi chifukwa amakhala otanganidwa ndipo amatenga shuga wambiri kuposa momwe maselo amachitira.
Kusanthula kwa Positron emission tomography (PET). Mwanayo wagona patebulo lomwe limadutsa pa makina a PET. Kupuma kwamutu ndi kansalu koyera kumathandiza mwanayo kugona. Kagawidwe kakang'ono ka shuga (radio) kamene kamabayidwa mu mtsempha wa mwanayo, ndipo sikaniyo imapanga chithunzi cha komwe glucose imagwiritsidwa ntchito mthupi. Maselo a khansa amawonekera bwino pachithunzichi chifukwa amatenga shuga wambiri kuposa momwe maselo amachitira.
  • Kuyesa kwa Ultrasound: Njira yomwe mafunde amawu amphamvu (ultrasound) amachotsedwa pamatumba kapena ziwalo zamkati ndikupanga mawonekedwe. Zolembawo amapanga chithunzi cha matupi amthupi otchedwa sonogram. Chithunzicho chimatha kusindikizidwa kuti chiwonedwe pambuyo pake.
M'mimba ultrasound. Transducer ya ultrasound yolumikizidwa ndi kompyuta imadutsa pamimba. Transducer ya ultrasound imaponya mafunde akumveka mkati ndi ziwalo zamkati kuti apange ma echo omwe amapanga sonogram (chithunzi cha pakompyuta).
  • Ntchito ya pulmonary test (PFT): Kuyesedwa kuti muwone momwe mapapo akugwirira ntchito. Imayeza kuchuluka kwa mapapo omwe mpweya ungasunge komanso momwe mpweya umalowera ndikutuluka m'mapapu. Imafotokozanso kuchuluka kwa oxygen yomwe imagwiritsidwa ntchito komanso kuchuluka kwa kaboni dayokisaidi popuma. Izi zimatchedwanso kuti "lung function test".
  • Bronchoscopy: Ndondomeko yoyang'ana mkati mwa trachea ndi njira yayikulu yamapapo m'mapapo m'malo osazolowereka. Bronchoscope imayikidwa kudzera pamphuno kapena pakamwa mu trachea ndi mapapu. Bronchoscope ndi chida chochepa, chokhala ngati chubu chokhala ndi kuwala ndi mandala owonera. Ikhozanso kukhala ndi chida chothandizira kuchotsa minofu, yomwe imayang'aniridwa ndi microscope ngati ili ndi khansa.
  • Endoscopy: Ndondomeko yoyang'ana ziwalo ndi zotupa mkati mwa thupi kuti muwone ngati sizili bwino m'matumbo kapena m'mapapu. Endoscope imalowetsedwa kudzera mu cheka (khungu) pakhungu kapena potsegula mthupi, monga pakamwa. Endoscope ndi chida chopyapyala, chokhala ngati chubu chokhala ndi kuwala ndi mandala owonera. Ikhozanso kukhala ndi chida chothandizira kuchotsa minofu kapena ma lymph node, omwe amayang'aniridwa ndi microscope ngati ali ndi matenda.
  • Biopsy: Kuchotsa kwa maselo kapena ziphuphu kotero kuti amatha kuwonedwa ndi microscope ndi wodwalayo kuti afufuze maselo a LCH. Kuzindikira LCH, biopsy ya mafupa, khungu, ma lymph node, chiwindi, kapena malo ena amatenda atha kuchitidwa.

Zinthu zina zimakhudzanso madandaulo (mwayi wochira) ndi njira zamankhwala.

LCH m'ziwalo monga khungu, mafupa, ma lymph node, kapena pituitary gland nthawi zambiri imachira ndi chithandizo ndipo amatchedwa "chiopsezo chochepa". LCH mu ndulu, chiwindi, kapena mafupa ndi ovuta kuchiza ndipo amatchedwa "chiopsezo chachikulu".

Njira zakulosera zamankhwala ndi chithandizo zimadalira izi:

  • Wodwala ali ndi zaka zingati akapezeka ndi LCH.
  • Ndi ziwalo ziti kapena machitidwe amthupi omwe amakhudzidwa ndi LCH.
  • Khansa imakhudza ziwalo kapena ziwalo zingati.
  • Kaya khansa imapezeka m'chiwindi, ndulu, mafupa, kapena mafupa ena pachigoba.
  • Khansara imayankha mwachangu mankhwala oyamba.
  • Kaya pali zosintha zina mumtundu wa BRAF.
  • Kaya khansa yapezeka kumene kapena yabwerera (yabwereranso).

Kwa makanda mpaka chaka chimodzi, LCH imatha kupita popanda chithandizo.

Magawo a LCH

MFUNDO ZOFUNIKA

  • Palibe njira yokhazikitsira Langerhans cell histiocytosis (LCH).
  • Kuchiza kwa LCH kutengera komwe ma cell a LCH amapezeka mthupi komanso ngati LCH ili pachiwopsezo chochepa kapena chiopsezo chachikulu.
  • LCH yaposachedwa

Palibe njira yokhazikitsira Langerhans cell histiocytosis (LCH).

Kukula kapena kufalikira kwa khansa nthawi zambiri kumafotokozedwa ngati magawo. Palibe njira yokhazikitsira LCH.

Kuchiza kwa LCH kutengera komwe ma cell a LCH amapezeka mthupi komanso ngati LCH ili pachiwopsezo chochepa kapena chiopsezo chachikulu.

LCH imafotokozedwa ngati matenda amtundu umodzi kapena matenda amisili, kutengera kuchuluka kwa thupi lomwe lakhudzidwa:

  • LCH imodzi-LCH: LCH imapezeka m'chigawo chimodzi cha thupi kapena thupi kapena magawo opitilira gawo limodzi la thupi. Bone ndi malo omwe amapezeka kwambiri kuti LCH ipezeke.
  • Multisystem LCH: LCH imachitika m'magulu awiri kapena kupitilira apo kapena machitidwe amthupi kapena imafalikira mthupi lonse. Multisystem LCH siyodziwika bwino kuposa njira imodzi ya LCH.

LCH ikhoza kukhudza ziwalo zomwe zili pachiwopsezo kapena ziwopsezo:

  • Ziwalo zomwe sizili pachiwopsezo chachikulu zimaphatikizapo khungu, mafupa, mapapo, ma lymph node, m'mimba, m'matumbo, pathupi, chithokomiro, thymus, ndi chapakati mantha dongosolo (CNS).
  • Ziwalo zowopsa kwambiri zimaphatikizapo chiwindi, ndulu, ndi mafupa.

LCH yaposachedwa

LCH yaposachedwa ndi khansa yomwe yabwereranso (kubwerera) itachiritsidwa. Khansara imatha kubwerera kumalo omwewo kapena mbali zina za thupi. Nthawi zambiri imabwereranso m'mafupa, m'makutu, pakhungu, kapena m'matumbo. LCH nthawi zambiri imabwereranso chaka chitatha chithandizo. LCH ikabwereranso, itha kutchedwanso kuti kuyambiranso.

Chidule cha Chithandizo cha LCH

MFUNDO ZOFUNIKA

  • Pali mitundu yosiyanasiyana ya chithandizo cha odwala omwe ali ndi Langerhans cell histiocytosis (LCH).
  • Ana omwe ali ndi LCH ayenera kukonzekera mankhwala awo ndi gulu la othandizira azaumoyo omwe ndi akatswiri othandiza khansa yaubwana.
  • Mitundu isanu ndi inayi yothandizidwa moyenera imagwiritsidwa ntchito:
  • Chemotherapy
  • Opaleshoni
  • Thandizo la radiation
  • Thandizo la Photodynamic
  • Chitetezo chamatenda
  • Chithandizo chofuna
  • Mankhwala ena
  • Kupanga khungu la tsinde
  • Kuwona
  • Mitundu yatsopano yamankhwala ikuyesedwa m'mayesero azachipatala.
  • Chithandizo cha Langerhans cell histiocytosis chingayambitse mavuto.
  • Odwala angaganize zopita nawo kukayezetsa.
  • Odwala amatha kulowa m'mayesero azachipatala asanafike, nthawi, kapena atayamba chithandizo chawo.
  • Chithandizo cha LCH chikasiya, zotupa zatsopano zitha kuwoneka kapena zotupa zakale zitha kubwereranso.
  • Mayeso otsatirawa angafunike.

Pali mitundu yosiyanasiyana ya chithandizo cha odwala omwe ali ndi Langerhans cell histiocytosis (LCH).

Pali mitundu yosiyanasiyana ya mankhwala kwa odwala omwe ali ndi LCH. Mankhwala ena ndi ofanana (mankhwala omwe akugwiritsidwa ntchito pano), ndipo ena akuyesedwa m'mayesero azachipatala. Kuyesedwa kwachipatala ndi kafukufuku wofufuza wothandizira kusintha chithandizo chamakono kapena kupeza zidziwitso zamankhwala atsopano kwa odwala khansa. Pamene mayesero azachipatala awonetsa kuti chithandizo chatsopano ndichabwino kuposa chithandizo chamankhwala, chithandizocho chitha kukhala chamankhwala wamba. Pomwe zingatheke, odwala ayenera kutenga nawo mbali pakuyesa zamankhwala kuti alandire chithandizo chatsopano cha LCH. Mayesero ena azachipatala ndi otseguka kwa odwala omwe sanayambe kulandira chithandizo.

Mayesero azachipatala akuchitika m'malo ambiri mdziko muno. Zambiri zamayesero azachipatala omwe akupitilira amapezeka patsamba la NCI. Kusankha chithandizo choyenera kwambiri ndi chisankho chomwe chimakhudza gulu la odwala, banja, komanso zamankhwala.

Ana omwe ali ndi LCH ayenera kukonzekera mankhwala awo ndi gulu la othandizira azaumoyo omwe ndi akatswiri othandiza khansa yaubwana.

Chithandizo chidzayang'aniridwa ndi oncologist wa ana, dokotala yemwe amadziwika bwino pochiza ana omwe ali ndi khansa. Ocologist wa ana amagwira ntchito ndi othandizira ena othandizira zaumoyo omwe ndi akatswiri pochiza ana omwe ali ndi LCH komanso omwe amakhazikika m'malo ena azamankhwala. Izi zingaphatikizepo akatswiri awa:

  • Dokotala wa ana.
  • Dokotala wa ana.
  • Dokotala wa hematologist.
  • Wofufuza oncologist.
  • Katswiri wa zamagulu.
  • Katswiri wazamaphunziro.
  • Katswiri wa namwino wa ana.
  • Katswiri wokonzanso.
  • Katswiri wa zamaganizo.
  • Wogwira ntchito.

Mitundu isanu ndi inayi yothandizidwa moyenera imagwiritsidwa ntchito:

Chemotherapy

Chemotherapy ndi mankhwala a khansa omwe amagwiritsa ntchito mankhwala oletsa kukula kwa maselo a khansa, mwina popha ma cell kapena kuwaletsa kuti asagawane. Chemotherapy ikamamwa pakamwa kapena kulowetsedwa mumtsempha kapena minofu, mankhwalawa amalowa m'magazi ndipo amatha kufikira ma cell a khansa mthupi lonse (systemic chemotherapy). Chemotherapy ikaikidwa molunjika pakhungu kapena m'matumbo a cerebrospinal, chiwalo, kapena thupi monga pamimba, mankhwalawa amakhudza kwambiri ma cell a khansa m'malo amenewo (chemotherapy am'madera).

Chemotherapy itha kuperekedwa ndi jakisoni kapena pakamwa kapena kupaka pakhungu pochiza LCH.

Opaleshoni

Opaleshoni itha kugwiritsidwa ntchito kuchotsa zotupa za LCH ndi minofu yaying'ono yapafupi. Curettage ndi mtundu wa opareshoni yomwe imagwiritsa ntchito curette (chida chakuthwa, chowoneka ngati supuni) kupukuta ma LCH m'mafupa.

Pakakhala kuwonongeka kwakukulu kwa chiwindi kapena m'mapapo, chiwalo chonsecho chimatha kuchotsedwa ndikusinthidwa ndi chiwindi kapena mapapu athanzi kuchokera kwa woperekayo.

Thandizo la radiation

Thandizo la radiation ndi chithandizo cha khansa chomwe chimagwiritsa ntchito ma x-ray amphamvu kapena mitundu ina ya radiation kuti iphe ma cell a khansa kapena kuti asakule. Thandizo la radiation lakunja limagwiritsa ntchito makina kunja kwa thupi kuti atumize cheza chakuthupi ndi khansa. Mankhwala a radiation a Ultraviolet B (UVB) atha kuperekedwa pogwiritsa ntchito nyali yapadera yomwe imawongolera ma radiation kuzilonda za khungu la LCH.

Thandizo la Photodynamic

Photodynamic therapy ndi mankhwala a khansa omwe amagwiritsa ntchito mankhwala osokoneza bongo komanso mtundu wina wa kuwala kwa laser kupha ma cell a khansa. Mankhwala omwe sagwira ntchito mpaka kuwalako kukuwala amalowetsedwa mumtsempha. Mankhwalawa amatenga zambiri m'maselo a khansa kuposa m'maselo abwinobwino. Kwa LCH, kuwala kwa laser kumayang'ana khungu ndipo mankhwalawa amakhala otakataka ndikupha ma cell a khansa. Chithandizo cha Photodynamic sichimawononga pang'ono minofu yathanzi. Odwala omwe ali ndi mankhwala a photodynamic sayenera kuthera nthawi yochuluka padzuwa.

Mu mtundu umodzi wa mankhwala a photodynamic, otchedwa psoralen ndi ultraviolet A (PUVA), wodwalayo amalandila mankhwala otchedwa psoralen ndiyeno radiation ya ultraviolet A imalozera pakhungu.

Chitetezo chamatenda

Immunotherapy ndi chithandizo chomwe chimagwiritsa ntchito chitetezo cha mthupi cha wodwalayo kuthana ndi khansa. Zinthu zomwe thupi limapanga kapena zopangidwa mu labotale zimagwiritsidwa ntchito kukulitsa, kuwongolera, kapena kubwezeretsa chitetezo chamthupi cha khansa. Chithandizo cha khansa choterechi chimatchedwanso biotherapy kapena biologic therapy. Pali mitundu yambiri ya immunotherapy:

  • Interferon imagwiritsidwa ntchito pochizira khungu la LCH.
  • Thalidomide imagwiritsidwa ntchito pochiza LCH.
  • Intravenous immunoglobulin (IVIG) imagwiritsidwa ntchito pochiza CNS neurodegenerative syndrome.

Chithandizo chofuna

Chithandizo choyenera ndi mtundu wa chithandizo chomwe chimagwiritsa ntchito mankhwala osokoneza bongo kapena zinthu zina kuti ziwononge maselo a khansa. Njira zochiritsira zomwe zingachitike zimatha kupweteketsa maselo abwinobwino kuposa chemotherapy kapena radiation. Pali mitundu yosiyanasiyana ya mankhwala omwe akulimbana nawo:

  • Tyrosine kinase inhibitors amaletsa zikwangwani zofunika kuti zotupa zikule. Ma Tyrosine kinase inhibitors omwe amagwiritsidwa ntchito pochiza LCH ndi awa:
  • Imatinib mesylate imayimitsa maselo am'magazi kuti asasanduke ma cell a dendritic omwe amatha kukhala maselo a khansa.
  • BRAF inhibitors amaletsa mapuloteni ofunikira kuti maselo akule ndipo amatha kupha ma cell a khansa. Mtundu wa BRAF umapezeka mu mawonekedwe osinthidwa (osinthidwa) mu LCH ina ndipo kuuletsa kungathandize kuti maselo a khansa asakule.
  • Vemurafenib ndi dabrafenib ndi BRAF inhibitors omwe amagwiritsidwa ntchito pochiza LCH.
  • Thandizo la monoclonal antibody limagwiritsa ntchito ma antibodies opangidwa mu labotore kuchokera ku mtundu umodzi wa chitetezo chamthupi. Ma antibodies awa amatha kuzindikira zinthu zomwe zili m'maselo a khansa kapena zinthu zabwinobwino zomwe zingathandize ma cell a khansa kukula. Ma antibodies amalumikizana ndi zinthuzo ndikupha ma cell a khansa, amalepheretsa kukula kwawo, kapena amalepheretsa kufalikira. Angagwiritsidwe ntchito okha kapena kunyamula mankhwala osokoneza bongo, poizoni, kapena zinthu zowononga radio kupita kuma cell a khansa. Ma antibodies a monoclonal amaperekedwa mwa kulowetsedwa.
  • Rituximab ndi antioclonal antibody yomwe imagwiritsidwa ntchito pochiza LCH.

Mankhwala ena

Mankhwala ena omwe amagwiritsidwa ntchito pochiza LCH ndi awa:

  • Mankhwala a Steroid, monga prednisone, amagwiritsidwa ntchito pochiza zotupa za LCH.
  • Mankhwala a bisphosphonate (monga pamidronate, zoledronate, kapena alendronate) amagwiritsidwa ntchito pochiza zotupa za LCH za mafupa ndikuchepetsa kupweteka kwa mafupa.
  • Mankhwala odana ndi zotupa ndi mankhwala (monga pioglitazone ndi rofecoxib) omwe amagwiritsidwa ntchito pochepetsa kutentha thupi, kutupa, kupweteka, komanso kufiira. Mankhwala oletsa kutupa ndi chemotherapy atha kuperekedwa limodzi kuti athetse achikulire omwe ali ndi mafupa a LCH.
  • Retinoids, monga isotretinoin, ndi mankhwala okhudzana ndi vitamini A omwe amachepetsa kukula kwa maselo a LCH pakhungu. Ma retinoids amatengedwa pakamwa.

Kupanga khungu la tsinde

Kuika ma cell a stem ndi njira yoperekera chemotherapy ndikusintha ma cell omwe amapanga magazi omwe awonongedwa ndi chithandizo cha LCH. Maselo otchedwa stem cells (maselo a magazi osakhwima) amachotsedwa m'magazi kapena m'mafupa a wodwalayo kapena woperekayo ndipo amaundana ndi kusungidwa. Chemotherapy ikamalizidwa, maselo osungidwa amasungunuka ndikubwezeretsedwanso mwa kulowetsedwa. Maselo amtundu wobwezeretsansowa amakula (ndikubwezeretsanso) maselo amthupi.

Kuwona

Kuyang'anitsitsa kumayang'anitsitsa matenda a wodwala popanda kupereka chithandizo chilichonse mpaka zizindikilo kapena zizindikiritso zikuwoneka kapena kusintha.

Mitundu yatsopano yamankhwala ikuyesedwa m'mayesero azachipatala.

Zambiri zamayeso azachipatala zimapezeka patsamba la NCI.

Chithandizo cha Langerhans cell histiocytosis chingayambitse mavuto.

Kuti mumve zambiri zamankhwala oyambilira omwe amayamba mukalandira chithandizo cha khansa, onani tsamba lathu la Zotsatira Zotsatira.

Zotsatira zoyipa za mankhwala a khansa omwe amayamba atalandira chithandizo ndikupitilira kwa miyezi kapena zaka amatchedwa zotsatira zakuchedwa. Zotsatira zakumapeto kwa chithandizo cha khansa zitha kuphatikizira izi:

  • Kukula pang'onopang'ono ndi chitukuko.
  • Kutaya kwakumva.
  • Matenda a mafupa, mano, chiwindi, ndi mapapo.
  • Kusintha kwa malingaliro, kumva, kuphunzira, kuganiza, kapena kukumbukira.
  • Khansa yachiwiri, monga leukemia, retinoblastoma, Ewing sarcoma, khansa ya ubongo kapena chiwindi.

Zotsatira zina mochedwa zimatha kuthandizidwa kapena kuwongoleredwa. Ndikofunika kulankhula ndi madotolo a mwana wanu zamankhwala omwe khansa imatha kukhala nawo pamwana wanu. (Onani chidule cha pa Zotsatira Zotsiriza za Chithandizo cha Khansa ya Ana kuti mumve zambiri.)

Odwala ambiri omwe ali ndi ma LCH azinthu zambiri amakhala ndi zovuta mochedwa chifukwa cha mankhwala kapena matenda omwewo. Odwalawa nthawi zambiri amakhala ndi mavuto azaumoyo omwe amakhudza moyo wawo.

Odwala angaganize zopita nawo kukayezetsa.

Kwa odwala ena, kutenga nawo mbali pakuyesa chithandizo chachipatala kungakhale njira yabwino kwambiri yothandizira. Mayesero azachipatala ndi gawo limodzi la kafukufuku wa khansa. Mayesero azachipatala amachitika kuti apeze ngati mankhwala atsopano a khansa ndi otetezeka komanso ogwira ntchito kapena abwinoko kuposa mankhwala wamba.

Njira zambiri zamankhwala zochiritsira khansa zimachokera kumayeso am'mbuyomu azachipatala. Odwala omwe amatenga nawo mbali pachipatala atha kulandira chithandizo chofananira kapena kukhala oyamba kulandira chithandizo chatsopano.

Odwala omwe amatenga nawo mbali pazoyeserera zamankhwala amathandizanso kukonza momwe khansa idzathandizire mtsogolo. Ngakhale mayesero azachipatala satsogolera kuchipatala chatsopano, nthawi zambiri amayankha mafunso ofunikira ndikuthandizira kupititsa patsogolo kafukufuku.

Odwala amatha kulowa m'mayesero azachipatala asanafike, nthawi, kapena atayamba chithandizo chawo.

Mayesero ena azachipatala amangophatikizapo odwala omwe sanalandire chithandizo. Mayesero ena amayesa chithandizo kwa odwala omwe khansa yawo sinakhale bwino. Palinso mayesero azachipatala omwe amayesa njira zatsopano zothetsera khansa kuti isabwererenso (kubwerera) kapena kuchepetsa zovuta zoyambitsidwa ndi khansa.

Mayesero azachipatala akuchitika m'malo ambiri mdziko muno. Zambiri zamayeso azachipatala othandizidwa ndi NCI zitha kupezeka patsamba lofufuza zamankhwala la NCI. Mayesero azachipatala othandizidwa ndi mabungwe ena amapezeka patsamba la ClinicalTrials.gov.

Chithandizo cha LCH chikasiya, zotupa zatsopano zitha kuwoneka kapena zotupa zakale zitha kubwereranso.

Odwala ambiri omwe ali ndi LCH amachira ndi mankhwala. Komabe, mankhwala akasiya, zilonda zatsopano zitha kuwoneka kapena zotha kubwereranso. Izi zimatchedwa kuyambiranso (kubwereza) ndipo zimatha kuchitika chaka chimodzi mutasiya mankhwala. Odwala omwe ali ndi matenda amisili yambiri amatha kuyambiranso. Malo omwe amapezeka ndi mafupa, makutu, kapena khungu. Matenda a shuga amathanso kuyamba. Malo ocheperako omwe amapezekanso ndi ma lymph node, mafupa, mafupa, chiwindi, kapena mapapo. Odwala ena amatha kuyambiranso kangapo pazaka zingapo.

Mayeso otsatirawa angafunike.

Chifukwa choopsa chotsegulanso, odwala a LCH ayenera kuyang'aniridwa kwa zaka zambiri. Mayeso ena omwe adachitika kuti azindikire LCH atha kubwerezedwa. Izi ndikuwona momwe mankhwalawa akugwirira ntchito komanso ngati pali zotupa zatsopano. Mayesowa atha kuphatikiza:

  • Kuyesa kwakuthupi.
  • Kuyesa kwamitsempha.
  • Kuyesa kwa Ultrasound.
  • MRI.
  • Kujambula kwa CT.
  • Sakanizani PET.

Mayesero ena omwe angafunike ndi awa:

  • Kuyesa kwa ubongo poyesa kutulutsa mayankho (BAER): Kuyesa komwe kumayesa momwe ubongo umayankhira pakudina phokoso kapena matchulidwe ena.
  • Ntchito ya pulmonary test (PFT): Kuyesedwa kuti muwone momwe mapapo akugwirira ntchito. Imayeza kuchuluka kwa mapapo omwe mpweya ungasunge komanso momwe mpweya umalowera ndikutuluka m'mapapu. Imafotokozanso kuchuluka kwa oxygen yomwe imagwiritsidwa ntchito komanso kuchuluka kwa kaboni dayokisaidi popuma. Izi zimatchedwanso kuyesa kwa mapapu.
  • X-ray pachifuwa: X-ray ya ziwalo ndi mafupa mkati mwa chifuwa. X-ray ndi mtundu wa mphamvu yamphamvu yomwe imatha kupyola thupi ndikupita mufilimu, ndikupanga chithunzi cha madera amkati mwa thupi.

Zotsatira zamayesowa zitha kuwonetsa ngati vuto lanu lasintha kapena ngati khansa yabwereranso (bwererani). Mayesowa nthawi zina amatchedwa kuyesa kutsata kapena kukayezetsa. Zisankho zakuti mupitilize, kusintha, kapena kusiya kulandira chithandizo zitha kutengera zotsatira za mayeso awa.

Kuchiza kwa LCH Yowopsa kwa Ana

M'chigawo chino

  • Zilonda Za Khungu
  • Zilonda m'mafupa kapena ziwalo zina zowopsa
  • Zilonda za CNS

Kuti mumve zambiri zamankhwala omwe atchulidwa pansipa, onani gawo la Chisankho Chachidule.

Zilonda Za Khungu

Chithandizo cha zotupa za khungu za Langerhans cell histiocytosis (LCH) zomwe zimapezeka kumene zingaphatikizepo izi:

  • Kuwona.

Pakakhala zotupa zazikulu, ululu, zilonda zam'mimba, kapena kutuluka magazi, mankhwala atha kukhala awa:

  • Steroid mankhwala.
  • Chemotherapy yoperekedwa pakamwa kapena mumtsempha.
  • Chemotherapy imagwiritsidwa ntchito pakhungu.
  • Thandizo la Photodynamic ndi psoralen ndi ultraviolet A (PUVA).
  • Chithandizo cha radiation cha UVB.

Zilonda m'mafupa kapena ziwalo zina zowopsa

Kuchiza kwa zilonda zam'mimba za LCH zomwe zatulutsidwa kumene kutsogolo, mbali, kapena kumbuyo kwa chigaza, kapena mafupa ena aliwonse atha kuphatikizira:

  • Opaleshoni (curettage) ndi kapena popanda mankhwala a steroid.
  • Mankhwala ochepetsa cheza ochepetsa zotupa zomwe zimakhudza ziwalo zapafupi.

Kuchiza kwa zotupa za LCH zomwe zatulutsidwa kumene m'mafupa ozungulira makutu kapena maso kumachitika kuti muchepetse chiopsezo cha matenda a shuga insipidus ndi zovuta zina zazitali. Chithandizo chingaphatikizepo:

  • Chemotherapy ndi mankhwala a steroid.
  • Opaleshoni (curettage).

Chithandizo cha zotupa za LCH zatsopano za msana kapena fupa la ntchafu zitha kuphatikizira izi:

  • Kuwona.
  • Mankhwala ochepetsa mphamvu ya radiation.
  • Chemotherapy, pazilonda zomwe zimafalikira kuchokera msana kupita minofu yapafupi.
  • Opaleshoni yolimbitsa fupa lofooka polimba kapena kusakaniza mafupa.

Chithandizo cha zilonda ziwiri kapena zingapo zamafupa chingaphatikizepo:

  • Chemotherapy ndi mankhwala a steroid.

Chithandizo cha zotupa ziwiri kapena zingapo zamfupa kuphatikiza zotupa pakhungu, zotupa za lymph node, kapena matenda a shuga insipidus atha kukhala:

  • Chemotherapy kapena wopanda mankhwala a steroid.
  • Mankhwala a bisphosphonate.

Zilonda za CNS

Chithandizo cha zotupa za LCH chapakati zamanjenje (CNS) zitha kuphatikizira izi:

  • Chemotherapy kapena wopanda mankhwala a steroid.

Chithandizo cha matenda opatsirana a LCH CNS neurodegenerative syndrome atha kuphatikizira:

  • Chithandizo choyenera ndi BRAF inhibitors (vemurafenib kapena dabrafenib).
  • Chemotherapy.
  • Chithandizo chojambulidwa ndi antioclonal antibody (rituximab).
  • Thandizo la retinoid.
  • Immunotherapy (IVIG) wokhala ndi chemotherapy kapena wopanda chemotherapy.

Gwiritsani ntchito kusaka kwathu kwamankhwala kuti mupeze mayesero azachipatala omwe amathandizidwa ndi NCI omwe akulandira odwala. Mutha kusaka mayesero kutengera mtundu wa khansa, zaka za wodwalayo, komanso komwe mayeserowo akuchitika. Zambiri pazokhudza mayesero azachipatala zimapezekanso.

Kuchiza kwa LCH Yowopsa kwa Ana

Kuti mumve zambiri zamankhwala omwe atchulidwa pansipa, onani gawo la Chisankho Chachidule.

Chithandizo cha zotupa za LCH zamagulu osiyanasiyana zomwe zapezeka kumene mu ndulu, chiwindi, kapena mafupa am'mimba ndi chiwalo china kapena tsamba lingaphatikizepo:

  • Chemotherapy ndi mankhwala a steroid. Mankhwala opitilira chemotherapy opitilira umodzi amathandizidwa kwa odwala omwe zotupa zawo sizimayankha kuchipatala.
  • Chithandizo choyenera (vemurafenib).
  • Kuika chiwindi kwa odwala omwe awonongeka chiwindi kwambiri.
  • Kuyesedwa kwachipatala komwe kumathandizira chithandizo cha wodwalayo kutengera mawonekedwe a khansa komanso momwe amathandizira pakalandira chithandizo.
  • Kuyesedwa kwachipatala kwa chemotherapy ndi mankhwala a steroid.

Chithandizo cha Recurrent, Refractory, ndi Progressive Childhood LCH mwa Ana

Kuti mumve zambiri zamankhwala omwe atchulidwa pansipa, onani gawo la Chisankho Chachidule.

LCH yaposachedwa ndi khansa yomwe imatha kupezeka kwakanthawi atalandira chithandizo ndikubwerera. Refractory LCH ndi khansa yomwe simakhala bwino ndi chithandizo. LCH yopita patsogolo ndi khansa yomwe imapitilizabe kukula panthawi yamankhwala.

Kuchiza kwa LCH kobwerezabwereza, kotsutsa, kapena koopsa komwe kungaphatikizepo:

  • Chemotherapy kapena wopanda mankhwala a steroid.
  • Mankhwala a bisphosphonate.

Kuchiza kwazinthu zowopsa, zobwezeretsa, kapena zopita patsogolo zoopsa za LCH zitha kuphatikizira izi:

  • Chemotherapy yapamwamba kwambiri.
  • Chithandizo choyenera (vemurafenib).
  • Kupanga khungu la tsinde.

Mankhwala ophunziridwa mobwerezabwereza, obwereza, kapena opitilira patsogolo ubwana wa LCH ndi awa:

  • Kuyesedwa kwachipatala komwe kumathandizira chithandizo cha wodwalayo kutengera mawonekedwe a khansa komanso momwe amathandizira pakalandira chithandizo.
  • Kuyesedwa kwachipatala komwe kumayang'ana chotupa cha wodwalayo ngati majini ena asintha. Mtundu wa mankhwala omwe akulimbikitsidwa omwe adzapatsidwe kwa wodwala umadalira mtundu wa kusintha kwa majini.

Chithandizo cha LCH mwa Akuluakulu

M'chigawo chino

  • Chithandizo cha LCH cha M'mapapo mwa Akuluakulu
  • Chithandizo cha LCH cha Bone mwa Akuluakulu
  • Kuchiza kwa LCH ya Khungu mwa Akuluakulu
  • Chithandizo cha Single-System ndi Multisystem LCH mwa Akuluakulu

Kuti mumve zambiri zamankhwala omwe atchulidwa pansipa, onani gawo la Chisankho Chachidule

Langerhans cell histiocytosis (LCH) mwa akulu ndi ofanana ndi LCH mwa ana ndipo amatha kupanga ziwalo ndi machitidwe omwewo monga momwe amachitira ndi ana. Izi zikuphatikiza ma endocrine ndi ma system apakati amanjenje, chiwindi, ndulu, mafupa, ndi m'mimba. Kwa akuluakulu, LCH imapezeka m'mapapu ngati matenda amtundu umodzi. LCH m'mapapo imachitika kawirikawiri mwa achinyamata omwe amasuta. LCH wamkulu imapezekanso mufupa kapena pakhungu.

Monga ana, zizindikiritso za LCH zimadalira komwe zimapezeka mthupi. Onani gawo la General Information pazizindikiro za LCH.

Kuyesa komwe kumayang'ana ziwalo ndi machitidwe amthupi komwe LCH imatha kugwiritsidwa ntchito kuti azindikire (kupeza) ndikuzindikira LCH. Onani gawo la General Information kuti mupeze mayeso ndi njira zomwe mungagwiritse ntchito pozindikira LCH.

Kwa akuluakulu, palibe zambiri zokhudzana ndi chithandizo chomwe chimagwira ntchito bwino. Nthawi zina, zidziwitso zimangobwera kuchokera ku malipoti okhudzana ndi matenda, chithandizo, ndikutsatiridwa ndi munthu m'modzi wamkulu kapena kagulu kakang'ono ka akulu omwe adapatsidwa mankhwala amtundu womwewo.

Chithandizo cha LCH cha M'mapapo mwa Akuluakulu

Chithandizo cha LCH cha m'mapapo mwa akulu chingaphatikizepo:

  • Kusiya kusuta kwa odwala onse omwe amasuta. Kuwonongeka kwamapapu kumawonjezeka pakapita nthawi kwa odwala omwe samasiya kusuta. Odwala omwe amasiya kusuta, kuwonongeka kwamapapu kumatha kukhala bwino kapena kumangokulira pakapita nthawi.
  • Chemotherapy.
  • Kuika mapapo kwa odwala omwe awonongeka kwambiri m'mapapo.

Nthawi zina LCH ya m'mapapo imatha kapena sichimakulirakulirabe ngakhale sichichiritsidwa.

Chithandizo cha LCH cha Bone mwa Akuluakulu

Chithandizo cha LCH chomwe chimakhudza fupa lokhalo mwa akulu ndi monga:

  • Kuchita opaleshoni kapena wopanda mankhwala a steroid.
  • Chemotherapy kapena popanda mankhwala ochepetsa mphamvu ya radiation.
  • Thandizo la radiation.
  • Thandizo la bisphosphonate, chifukwa cha kupweteka kwambiri kwa mafupa.
  • Mankhwala oletsa kutupa ndi chemotherapy.

Kuchiza kwa LCH ya Khungu mwa Akuluakulu

Kuchiza kwa LCH komwe kumakhudza khungu lokha mwa akulu kungaphatikizepo:

  • Opaleshoni.
  • Steroid kapena mankhwala ena amagwiritsidwa ntchito pakhungu lanu.
  • Mankhwala a Photodynamic okhala ndi psoralen ndi ma radiation a ultraviolet A (PUVA).
  • Chithandizo cha radiation cha UVB.
  • Chemotherapy kapena immunotherapy yoperekedwa pakamwa, monga methotrexate, thalidomide, hydroxyurea, kapena interferon.
  • Mankhwala a Retinoid atha kugwiritsidwa ntchito ngati zotupa pakhungu sizikhala bwino ndi chithandizo china.

Chithandizo cha LCH chomwe chimakhudza khungu ndi machitidwe ena amthupi mwa akulu atha kuphatikiza:

  • Chemotherapy.

Chithandizo cha Single-System ndi Multisystem LCH mwa Akuluakulu

Chithandizo cha matenda amtundu umodzi komanso matenda amisili mwa akulu omwe samakhudza mapapo, fupa, kapena khungu atha kukhala:

  • Chemotherapy.
  • Chithandizo choyenera (imatinib, kapena vemurafenib).

Kuti mumve zambiri zamayesero a LCH kwa akulu, onani tsamba la Histiocyte SocietyExit Disclaimer.

Gwiritsani ntchito kusaka kwathu kwamankhwala kuti mupeze mayesero azachipatala omwe amathandizidwa ndi NCI omwe akulandira odwala. Mutha kusaka mayesero kutengera mtundu wa khansa, zaka za wodwalayo, komanso komwe mayeserowo akuchitika. Zambiri pazokhudza mayesero azachipatala zimapezekanso.

Kuti mudziwe zambiri za Langerhans Cell Histiocytosis

Kuti mumve zambiri kuchokera ku National Cancer Institute yokhudza chithandizo cha Langerhans cell histiocytosis, onani izi:

  • Computed Tomography (CT) Zithunzi ndi Khansa
  • Thandizo la Photodynamic la Khansa
  • Immunotherapy Kuchiza Khansa
  • Njira Zochizira Khansa
  • Kusandulika Kwamaselo Opangira Magazi

Kuti mumve zambiri za khansa yaubwana ndi zina zothandiza za khansa, onani izi:

  • Za Khansa
  • Khansa Za Ana
  • Cure Search for Cancer ya Ana Tulukani Chodzikanira
  • Zotsatira Zochedwetsa Khansa Yaana
  • Achinyamata ndi Achinyamata Achikulire ndi Khansa
  • Ana omwe ali ndi khansa: Upangiri wa Makolo
  • Khansa mwa Ana ndi Achinyamata
  • Kusinthana
  • Kulimbana ndi khansa
  • Mafunso oti mufunse dokotala wanu za khansa
  • Kwa Opulumuka ndi Owasamalira


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