Types/brain/patient/child-glioma-treatment-pdq

Kuchiza Kwaubongo Stem Glioma Treatment (®) -Patient Version

Zambiri Pazokhudza Ubongo Wotsutsa Glioma

MFUNDO ZOFUNIKA

• Ubongo waubwana tsinde glioma ndi matenda omwe ma cell a benign (noncancer) kapena owopsa (khansa) amapangidwa m'matumba a ubongo.

• Pali mitundu iwiri yamatenda am'magazi amwana mwa ana.

• Zomwe zimayambitsa zotupa zambiri muubongo sizidziwika.

• Zizindikiro za ubongo wa glioma sizofanana mwana aliyense.

• Mayeso omwe amafufuza ubongo amagwiritsidwa ntchito kuti azindikire (kupeza) ubongo waubongo glioma.

• Chidziwitso chitha kuchitidwa kuti mupeze mitundu ina ya ubongo yotulutsa glioma.

• Zinthu zina zimakhudzanso madandaulo (mwayi wochira).

Ubongo waubwana tsinde glioma ndi matenda omwe ma cell a benign (noncancer) kapena owopsa (khansa) amapangidwa m'matumba a ubongo.

Gliomas ndi zotupa zopangidwa kuchokera ku maselo am'magazi. Maselo amtundu wa ubongo amasunga timitsempha tam'malo mwake, amabweretsa chakudya ndi mpweya m'mitsempha yamitsempha, komanso amathandiza kuteteza maselo amitsempha kumatenda, monga matenda. Mu ubongo tsinde la glioma, maselo am'magazi amtundu waubongo amakhudzidwa.

Tsinde laubongo limapangidwa ndi midbrain, pons, ndi medulla. Ndilo gawo lotsika kwambiri laubongo ndipo limalumikizana ndi msana, pamwamba pamsana pakhosi. Tsinde laubongo limayang'anira ntchito zofunikira monga kupuma, kugunda kwa mtima, ndi kuthamanga kwa magazi, komanso mitsempha ndi minofu yomwe imagwiritsidwa ntchito pakuwona, kumva, kuyenda, kulankhula, ndi kudya.

Ambiri mwaubongo otulutsa ma gliomas ndimafinya amkati a pontine gliomas (DIPG), omwe amakhala m'maponi. Ma gliomas owoneka bwino mbali zina za tsinde laubongo.

Anatomy yaubongo. Dera la supratentorial (kumtunda kwaubongo) limakhala ndi cerebrum, lateral ventricle ndi third ventricle (yokhala ndi cerebrospinal fluid yowonetsedwa mu buluu), choroid plexus, pineal gland, hypothalamus, pituitary gland, ndi optic nerve. Malo am'mbuyo a fossa / infratentorial (mbali yakumbuyo kwakubongo) imakhala ndi cerebellum, tectum, ventricle yachinayi, ndi tsinde laubongo (midbrain, pons, and medulla). The tentorium imasiyanitsa supratentorium ndi infratentorium (kumanja). Chigaza ndi meninja zimateteza ubongo ndi msana (kumanzere).

Zotupa zamaubongo ndimtundu wachiwiri wofala kwambiri wa khansa mwa ana.

Chidule ichi ndi cha chithandizo cha zotupa zoyambira muubongo (zotupa zomwe zimayamba muubongo). Chithandizo cha zotupa zamaubongo zamatenda, zomwe ndi zotupa zopangidwa ndi maselo a khansa omwe amayambira mbali zina za thupi ndikufalikira kuubongo, sizinafotokozedwe mwachidule.

Zotupa zamaubongo zimatha kupezeka mwa ana ndi akulu omwe; komabe, chithandizo cha ana chikhoza kukhala chosiyana ndi chithandizo cha akulu. Kuti mumve zambiri zamankhwala am'mimba mwa akulu, onani mwachidule Chithandizo cha Adult Central Nervous System Tumors Treatment.

Pali mitundu iwiri yamatenda am'magazi amwana mwa ana.

Ngakhale DIPG ndi ubongo wopanga glioma mawonekedwe amtundu womwewo wa cell, amachita mosiyanasiyana:

• DIPG . DIPG ndi chotupa chomwe chikukula mwachangu chomwe chimapanga ma pon. DIPG ndi yovuta kuchiza ndipo imakhala ndi vuto losazindikira (mwayi wochira) chifukwa cha izi:

• Si chotupa chodziwika bwino ndipo chimafalikira pakati pama cell athanzi mu tsinde laubongo.

• Ntchito zofunika, monga kupuma komanso kugunda kwa mtima, zimatha kukhudzidwa.

• Maganizo a ubongo amachokera glioma. A focal glioma ndi chotupa chomwe chimakula pang'onopang'ono chomwe chimapangidwa kunja kwa ma pons komanso gawo limodzi lokha la tsinde laubongo. Ndikosavuta kuchiza komanso kuyerekezera kuposa DIPG.

Zomwe zimayambitsa zotupa zambiri muubongo sizidziwika.

Chilichonse chomwe chimakulitsa chiopsezo chotenga matenda chimatchedwa chiopsezo. Kukhala ndi chiwopsezo sikutanthauza kuti udzakhala ndi khansa; kusakhala ndi zoopsa sikutanthauza kuti simudzakhala ndi khansa. Lankhulani ndi dokotala wa mwana wanu ngati mukuganiza kuti mwana wanu akhoza kukhala pachiwopsezo. Zowopsa zomwe zingayambitse ubongo glioma ndizo:

• Kukhala ndi zovuta zina zamtundu, monga neurofibromatosis mtundu 1 (NF1).

Zizindikiro za ubongo wa glioma sizofanana mwana aliyense.

Zizindikiro zimadalira izi:

• Kumene chotupacho chimapanga muubongo.

• Kukula kwa chotupacho komanso ngati chafalikira mu tsinde lonse laubongo.

• Kutupa kumakula msanga.

• Msinkhu wa mwana ndi gawo lakukula.

Zizindikiro zimatha kuyambitsidwa ndi ubongo wamagulu amadzimadzi kapena zina. Funsani dokotala wa mwana wanu ngati mwana wanu ali ndi zotsatirazi:

• Vuto ndi kuyenda kwa diso (diso latembenukira mkati).

• Mavuto masomphenya.

• Mutu wam'mawa kapena mutu womwe umatha pambuyo posanza.

• Nseru ndi kusanza.

• Kugona kwachilendo.

• Kutaya kusuntha mbali imodzi yamaso kapena thupi.

• Kutayika bwino komanso kuyenda movutikira.

• Mphamvu yochulukirapo kuposa masiku onse.

• Kusintha kwamakhalidwe.

• Kuvuta kuphunzira kusukulu.

Mayeso omwe amafufuza ubongo amagwiritsidwa ntchito kuti azindikire (kupeza) ubongo waubongo glioma.

Mayeso ndi njira zotsatirazi zitha kugwiritsidwa ntchito:

• Kuyezetsa thupi komanso mbiri yaumoyo: Kuyesedwa kwa thupi kuti muwone zizindikiritso zaumoyo, kuphatikizapo kuyang'ana ngati pali matenda, monga zotupa kapena china chilichonse chomwe chikuwoneka chachilendo. Mbiri yokhudzana ndi thanzi la wodwalayo komanso matenda am'mbuyomu komanso chithandizo chamankhwala adzachitidwanso.

• Kuyesa kwamitsempha: Mafunso ndi mayeso angapo owunika ubongo, msana, ndi kugwira ntchito kwa mitsempha. Mayesowa amawunika momwe munthu amaganizira, momwe amagwirira ntchito, komanso momwe angayendere bwino, komanso momwe minofu, mphamvu, ndi malingaliro zimagwirira ntchito. Izi amathanso kutchedwa mayeso a neuro kapena mayeso a neurologic.

• MRI (magnetic resonance imaging) yokhala ndi gadolinium: Njira yomwe imagwiritsa ntchito maginito, mafunde a wailesi, ndi kompyuta kuti ipange zithunzi zingapo zazomwe zili mkati mwa ubongo. Chinthu chotchedwa gadolinium chimalowetsedwa mumtsempha. Gadolinium imasonkhanitsa mozungulira maselo a khansa kuti athe kuwonekera pachithunzichi. Njirayi imatchedwanso nuclear magnetic resonance imaging (NMRI).

Chidziwitso chitha kuchitidwa kuti mupeze mitundu ina ya ubongo yotulutsa glioma.

Ngati kusanthula kwa MRI kumawoneka ngati chotupacho ndi DIPG, nthawi zambiri kafukufuku samachitika ndipo chotupacho sichichotsedwa. Zotsatira za kusanthula kwa MRI zikakhala zosatsimikizika, kafukufuku amatha kuchitidwa.

Ngati kusanthula kwa MRI kumawoneka ngati ubongo wa glioma, kafukufuku amatha kuchitidwa. Gawo lina la chigaza limachotsedwa ndipo singano imagwiritsidwa ntchito pochotsa gawo la mnofu wa muubongo. Nthawi zina, singanoyo imatsogozedwa ndi kompyuta. Wodwala amayang'ana minofu pansi pa microscope kuti ayang'ane maselo a khansa. Ngati ma cell a khansa apezeka, adotolo amachotsa chotupa chonse momwe angathere pochitidwa opaleshoni yomweyo.

Craniotomy: Chotsegula chimapangidwa ndi chigaza ndipo chidutswa cha chigaza chimachotsedwa kuti chiwonetse gawo laubongo.

Mayeso otsatirawa atha kuchitidwa pazitsanzo za minofu yomwe idachotsedwa pa biopsy kapena opaleshoni:

• Immunohistochemistry: Kuyesa kwa labotale komwe kumagwiritsa ntchito ma antibodies kuti aone ngati ali ndi ma antigen (zolembera) muzitsanzo za minofu ya wodwala. Ma antibodies nthawi zambiri amalumikizidwa ndi enzyme kapena utoto wa fulorosenti. Ma antibodies atagwirizana ndi antigen inayake munthawi ya minofu, enzyme kapena utoto umayambitsidwa, ndipo antigen imatha kuwonedwa ndi microscope. Mayeso amtunduwu amagwiritsidwa ntchito pothandiza kuzindikira khansa ndikuthandizira kudziwa khansa yamtundu wina wa khansa.

Zinthu zina zimakhudzanso madandaulo (mwayi wochira).

Kutulutsa kwamwana kumadalira izi:

• Mtundu wa brain stem glioma (DIPG kapena focal glioma).

• Komwe chotupacho chimapezeka muubongo ndipo ngati chafalikira mkati mwa tsinde laubongo.

• Zaka za mwana atadziwika.

• Kutalika kwa nthawi yayitali mwanayo ali ndi zizindikilo asanazindikiridwe.

• Kaya mwanayo ali ndi vuto lotchedwa neurofibromatosis mtundu 1.

• Kaya pali kusintha kwina mumtundu wa H3 K27m.

• Kaya chotupacho chapezeka kumene kapena chachitika (kubwerera).

Ana ambiri omwe ali ndi DIPG amakhala osakwana miyezi 18 atazindikira. Ana omwe ali ndi focal glioma nthawi zambiri amakhala zaka zoposa 5.

Magawo a Ubongo wa Ubongo Glioma

MFUNDO ZOFUNIKA

• Dongosolo lothandizira khansa limadalira ngati chotupacho chili m'dera limodzi laubongo kapena chafalikira muubongo wonse.

Dongosolo lothandizira khansa limadalira ngati chotupacho chili m'dera limodzi laubongo kapena chafalikira muubongo wonse.

Kuyika masitepe ndi njira yomwe imagwiritsidwa ntchito kuti mudziwe kuchuluka kwa khansa yomwe ilipo komanso ngati khansa yafalikira. Ndikofunikira kudziwa siteji kuti mukonzekere chithandizo.

Palibe njira yokhazikika yaubongo yotengera glioma yaubwana. Chithandizo chimachokera pa izi:

• Kaya chotupacho chapezeka kumene kapena chabwerezabwereza (wabweranso atalandira chithandizo).

• Mtundu wa chotupa (mwina chofalikira chamkati cha pontine glioma kapena focal glioma).

A focal brain stem glioma atha kubwereranso zaka zambiri atalandira chithandizo. Chotupacho chimatha kubwerera ku ubongo kapena mbali zina zamkati mwamanjenje. Asanapatsidwe chithandizo cha khansa, kuyerekezera kujambula, kuyesa biopsy, kapena kuchitidwa opaleshoni kuti zitsimikizire kuti pali khansa ndikupeza kuchuluka kwa khansa.

Chithandizo Chosankha Mwachidule

MFUNDO ZOFUNIKA

• Pali mitundu yosiyanasiyana ya chithandizo cha ana omwe ali ndi tsinde la glioma yaubongo.

• Ana omwe ali ndi vuto la ubongo glioma ayenera kukonzekera mankhwala awo ndi gulu la othandizira azaumoyo omwe ndi akatswiri othandizira

zotupa zaubongo zaubwana.

• Mitundu isanu yamankhwala amtundu uliwonse imagwiritsidwa ntchito:

• Opaleshoni

• Thandizo la radiation

• Chemotherapy

• Kusokonekera kwa madzi amadzimadzi

• Kuwona

• Mitundu yatsopano yamankhwala ikuyesedwa m'mayesero azachipatala.

• Chithandizo chofuna

• Chithandizo cha ubongo wothandizira glioma chitha kuyambitsa zovuta.

• Odwala angaganize zopita nawo kukayezetsa.

• Odwala amatha kulowa m'mayesero azachipatala asanayambe, asanayambe, kapena atayamba kulandira chithandizo cha khansa.

• Mayeso otsatirawa angafunike.

Pali mitundu yosiyanasiyana ya chithandizo cha ana omwe ali ndi tsinde la glioma yaubongo.

Pali mitundu yosiyanasiyana ya chithandizo kwa ana omwe ali ndi tsinde la glioma yaubongo. Mankhwala ena ndi ofanana (mankhwala omwe akugwiritsidwa ntchito pano), ndipo ena akuyesedwa m'mayesero azachipatala. Kuyesedwa kwachipatala ndi kafukufuku wofufuza wothandizira kusintha chithandizo chamakono kapena kupeza zidziwitso zamankhwala atsopano kwa odwala khansa. Pamene mayesero azachipatala awonetsa kuti chithandizo chatsopano ndichabwino kuposa chithandizo chamankhwala, chithandizocho chitha kukhala chamankhwala wamba.

Chifukwa khansa mwa ana ndiyosowa, kutenga nawo mbali pakuyesa kwachipatala kuyenera kuganiziridwa. Mayesero ena azachipatala ndi otseguka kwa odwala omwe sanayambe kulandira chithandizo.

Ana omwe ali ndi stem stem glioma ayenera kukonzekera kukonzekera ndi gulu la othandizira azaumoyo omwe ndi akatswiri pochiza zotupa zamaubongo aubwana.

Chithandizo chidzayang'aniridwa ndi oncologist wa ana, dokotala yemwe amadziwika bwino pochiza ana omwe ali ndi khansa. Katswiri wa oncologist amagwira ana ndi othandizira ena othandizira zaumoyo omwe ndi akatswiri pochiza ana omwe ali ndi zotupa zamaubongo komanso omwe amakhazikika m'malo ena azamankhwala. Izi zingaphatikizepo akatswiri awa:

• Dokotala wa ana.

• Neurosurgeon.

• Neuropathologist.

• Dokotala oncologist wa radiation.

• Dokotala wa neuro-oncologist.

• Katswiri wa zamagulu.

• Neuroradiologist.

• Katswiri wazamaphunziro.

• Katswiri wa zamaganizo.

• Katswiri wokonzanso.

• Wogwira ntchito.

• Katswiri wa moyo wa ana.

Mitundu isanu yamankhwala amtundu uliwonse imagwiritsidwa ntchito:

Opaleshoni

Biopsy kapena opareshoni yochotsa DIPG sizimachitika kawirikawiri chifukwa cha izi:

• DIPG si misa imodzi. Imafalikira pakati pamaselo athanzi muubongo.

• Ntchito zofunika, monga kupuma ndi kugunda kwa mtima kumatha kukhudzidwa.

Chidziwitso chodziwitsa kapena kuchitira opaleshoni kuti achotse chotupacho chitha kugwiritsidwa ntchito paubongo wa ubongo wa glioma.

Thandizo la radiation

Thandizo la radiation ndi chithandizo cha khansa chomwe chimagwiritsa ntchito ma x-ray amphamvu kapena mitundu ina ya radiation kuti iphe ma cell a khansa kapena kuti asakule. Pali mitundu iwiri ya mankhwala a radiation:

• Mankhwala ochiritsira akunja amagwiritsa ntchito makina kunja kwa thupi kuti atumize cheza chaku khansa.

• Njira yothandizira poizoniyu yamkati imagwiritsa ntchito mankhwala a radioactive otsekedwa ndi singano, njere, mawaya, kapena ma catheters omwe amayikidwa mwachindunji kapena pafupi ndi khansa.

Momwe mankhwalawa amaperekera zimadalira mtundu wa khansa yomwe ikuthandizidwa. Thandizo la radiation lakunja limagwiritsidwa ntchito pochiza DIPG. Mankhwala akunja ndi / kapena radiation amkati amatha kugwiritsidwa ntchito kuthana ndi ma gliomas amkati am'magazi.

Miyezi ingapo kuchokera pomwe mankhwala a radiation amapita muubongo, kuyesa kwa kuyerekezera kumatha kuwonetsa kusintha kwa minofu yaubongo. Kusintha kumeneku kumatha kuyambitsidwa ndi mankhwala a radiation kapena kungatanthauze kuti chotupacho chikukula. Ndikofunika kuonetsetsa kuti chotupacho chikukula musanaperekedwe mankhwala ena.

Chemotherapy

Chemotherapy ndi mankhwala a khansa omwe amagwiritsa ntchito mankhwala oletsa kukula kwa maselo a khansa, mwina popha ma cell kapena kuwaletsa kuti asagawane. Chemotherapy ikamamwa pakamwa kapena kulowetsedwa mumtsempha kapena minofu, mankhwalawa amalowa m'magazi ndipo amatha kufikira ma cell a khansa mthupi lonse (systemic chemotherapy). Chemotherapy ikayikidwa mwachindunji mu cerebrospinal fluid, chiwalo, kapena thupi monga pamimba, mankhwalawa amakhudza kwambiri ma cell a khansa m'malo amenewo (chemotherapy am'madera). Momwe chemotherapy imaperekedwa imadalira mtundu wa khansa yomwe ikuchitidwa.

Chifukwa chithandizo cha radiation kuubongo chimatha kukhudza kukula ndi kukula kwaubongo mwa ana aang'ono, chemotherapy imatha kuperekedwa kuti ichedwetse kapena kuchepetsa kufunika kwa mankhwala a radiation.

Kusokonekera kwa madzi amadzimadzi

Cerebrospinal fluid diversion ndi njira yomwe amagwiritsira ntchito kukhetsa madzimadzi omwe apanga muubongo. Thupi (chubu lalitali, locheperako) limayikidwa mu ventricle (malo odzaza ndi madzi) aubongo ndipo amaluka pansi pa khungu kupita mbali ina ya thupi, nthawi zambiri pamimba. Shunt imatenga madzi owonjezera kuchokera kuubongo kuti itengeke kwina kulikonse mthupi.

Kusokonekera kwa Cerebrospinal fluid (CSF). CSF yowonjezera imachotsedwa mu ventricle muubongo kudzera mu shunt (chubu) ndipo imatsanulidwa m'mimba. Valve imayendetsa kayendedwe ka CSF.

Kuwona

Kuyang'anitsitsa kumayang'anitsitsa matenda a wodwala popanda kupereka chithandizo chilichonse mpaka zizindikilo kapena zizindikiritso zikuwoneka kapena kusintha.

Mitundu yatsopano yamankhwala ikuyesedwa m'mayesero azachipatala.

Gawo lachiduleli likufotokoza zamankhwala omwe akuwerengedwa m'mayesero azachipatala. Sizingatchule chithandizo chilichonse chatsopano chomwe akuphunzira. Zambiri zamayeso azachipatala zimapezeka patsamba la NCI.

Chithandizo chofuna

Chithandizo choyenera ndi mtundu wa mankhwala omwe amagwiritsa ntchito mankhwala osokoneza bongo kapena zinthu zina kuti azindikire ndikuukira maselo amtundu wa khansa osavulaza maselo abwinobwino.

Pali mitundu yosiyanasiyana yamankhwala omwe akuphunziridwa pochiza ma gliomas am'magazi:

• Mankhwala a Kinase inhibitor amaletsa mapuloteni ena, monga BRAF kapena MEK, omwe angathandize kuti maselo a khansa asakule kapena kugawikana. Dabrafenib (BRAF kinase inhibitor) ndi trametinib (MEK kinase inhibitor) akuwerengedwa kuti athandizire kuthana ndi focal glioma komanso ubongo womwe umapezekanso glioma.

• Chithandizo cha Histone deacetylase inhibitor (HDI) chitha kuyimitsa kukula kwa zotupa mwa kulepheretsa ma enzyme ena ofunikira kuti maselo akule. Ilinso mtundu wa wothandizira angiogenesis. Panobinostat ikuwerengedwa pochiza DIPG yomwe sinayankhe kuchipatala kapena kuyambiranso.

• Thandizo la monoclonal antibody limagwiritsa ntchito ma antibodies opangidwa mu labotore kuchokera ku mtundu umodzi wa chitetezo chamthupi. Ma antibodies awa amatha kuzindikira zinthu zomwe zili m'maselo a khansa kapena zinthu zabwinobwino zomwe zingathandize ma cell a khansa kukula. Ma antibodies amalumikizana ndi zinthuzo ndikupha ma cell a khansa, amalepheretsa kukula kwawo, kapena amalepheretsa kufalikira.

A antioclonal antibody, APX005M, amamangiriza CD40, cholandirira chomwe chimapezeka pamaselo ena amthupi komanso ma khansa ena. Itha kulimbana ndi khansa polimbikitsa chitetezo cha mthupi komanso pochepetsa kukula kwa maselo a khansa. Ikuwerengedwa pochizira zotupa zamaubongo aana zomwe zikukula, kufalikira, kapena kukulira (kupita patsogolo), kapena ku DIPG yomwe yangotuluka kumene.

Chithandizo cha ubongo wothandizira glioma chitha kuyambitsa zovuta.

Kuti mumve zambiri zamankhwala oyambilira omwe amayamba mukalandira chithandizo cha khansa, onani tsamba lathu la Zotsatira Zotsatira.

Zotsatira zoyipa za mankhwala a khansa omwe amayamba atalandira chithandizo ndikupitilira kwa miyezi kapena zaka amatchedwa zotsatira zakuchedwa. Zotsatira zakumapeto zimatha kuphatikiza izi:

• Mavuto athupi.

• Kusintha kwa malingaliro, malingaliro, kuganiza, kuphunzira, kapena kukumbukira.

• Khansa yachiwiri (mitundu yatsopano ya khansa).

Zotsatira zina mochedwa zimatha kuthandizidwa kapena kuwongoleredwa. Ndikofunika kulankhula ndi madotolo a mwana wanu zamankhwala omwe khansa imatha kukhala nawo pamwana wanu. (Onani chidule cha pa Zotsatira Zotsiriza za Chithandizo cha Khansa ya Ana kuti mumve zambiri).

Odwala angaganize zopita nawo kukayezetsa.

Zambiri zamayeso azachipatala zimapezeka patsamba la NCI.

Kwa odwala ena, kutenga nawo mbali pakuyesa chithandizo chachipatala kungakhale njira yabwino kwambiri yothandizira. Mayesero azachipatala ndi gawo limodzi la kafukufuku wa khansa. Mayesero azachipatala amachitika kuti apeze ngati mankhwala atsopano a khansa ndi otetezeka komanso ogwira ntchito kapena abwinoko kuposa mankhwala wamba.

Njira zambiri zamankhwala zochiritsira khansa zimachokera kumayeso am'mbuyomu azachipatala. Odwala omwe amatenga nawo mbali pachipatala atha kulandira chithandizo chofananira kapena kukhala oyamba kulandira chithandizo chatsopano.

Odwala omwe amatenga nawo mbali pazoyeserera zamankhwala amathandizanso kukonza momwe khansa idzathandizire mtsogolo. Ngakhale mayesero azachipatala satsogolera kuchipatala chatsopano, nthawi zambiri amayankha mafunso ofunikira ndikuthandizira kupititsa patsogolo kafukufuku.

Odwala amatha kulowa m'mayesero azachipatala asanayambe, asanayambe, kapena atayamba kulandira chithandizo cha khansa.

Mayesero ena azachipatala amangophatikizapo odwala omwe sanalandire chithandizo. Mayesero ena amayesa chithandizo kwa odwala omwe khansa yawo sinakhale bwino. Palinso mayesero azachipatala omwe amayesa njira zatsopano zothetsera khansa kuti isabwererenso (kubwerera) kapena kuchepetsa zovuta zoyambitsidwa ndi khansa.

Mayesero azachipatala akuchitika m'malo ambiri mdziko muno. Zambiri zamayeso azachipatala othandizidwa ndi NCI zitha kupezeka patsamba lofufuza zamankhwala la NCI. Mayesero azachipatala othandizidwa ndi mabungwe ena amapezeka patsamba la ClinicalTrials.gov.

Mayeso otsatirawa angafunike.

Ena mwa mayesero omwe adachitika kuti apeze khansa kapena kuti adziwe momwe khansa iliri angabwerezedwenso. Mayesero ena adzabwerezedwa kuti awone momwe mankhwalawa akugwirira ntchito. Zisankho zakuti mupitilize, kusintha, kapena kusiya kulandira chithandizo zitha kutengera zotsatira za mayeso awa.

Kuyesaku kumangopitilira kuchitika nthawi ndi nthawi mankhwala atatha. Zotsatira zamayesowa zitha kuwonetsa ngati matenda a mwana wanu asintha kapena ngati khansa yabwereranso (kubwerera). Mayesowa nthawi zina amatchedwa kuyesa kutsata kapena kukayezetsa.

Ngati zotsatira zoyesa kujambula zomwe zachitika atalandira chithandizo cha DIPG zikuwonetsa unyinji muubongo, kafukufuku amatha kuchitidwa kuti apeze ngati amapangidwa ndi maselo otupa kapena ngati khansa yatsopano ikukula. Kwa ana omwe akuyembekezeka kukhala ndi moyo nthawi yayitali, ma MRIs nthawi zonse amatha kuchitidwa kuti awone ngati khansa yabwerera.

Chithandizo cha DIPG

Kuti mumve zambiri zamankhwala omwe atchulidwa pansipa, onani gawo la Chisankho Chachidule.

Matenda omwe angotulukiridwa kumene ali ndi ubongo wamkati wotchedwa glioma (DIPG) ndi chotupa chomwe sanalandire chithandizo. Mwanayo atha kukhala kuti walandila mankhwala kapena mankhwala kuti achepetse zizindikilo kapena zizindikilo zomwe zimayambitsidwa ndi chotupacho.

Chithandizo chovomerezeka cha DIPG chingaphatikizepo izi:

• Thandizo la radiation lakunja.

• Chemotherapy (mwa makanda).

• Kuyesedwa kwachipatala kwa chithandizo chatsopano.

Kuchiza kwa Focal Brain Stem Glioma

Matenda omwe angotulukiridwa kumene kumene mwa ana otchedwa glioma ndi chotupa chomwe sanalandire chithandizo. Mwanayo atha kukhala kuti walandila mankhwala kapena mankhwala kuti achepetse zizindikilo kapena zizindikilo zomwe zimayambitsidwa ndi chotupacho.

Chithandizo cha focal glioma chingaphatikizepo izi:

• Kuchita opaleshoni kuti achotse chotupacho kumatha kutsatiridwa ndi chemotherapy ndi / kapena chithandizo chama radiation chakunja.

• Kuwona zotupa zazing'ono zomwe zimakula pang'onopang'ono. Kusokonekera kwamadzimadzi kumatha kuchitika pakakhala madzi owonjezera muubongo.

• Njira yothandizira poizoniyu ndi mbewu za radioactive, kapena chemotherapy, kapena popanda, pomwe chotupacho sichingachotsedwe ndi opaleshoni.

• Kuyesedwa kwachipatala kwa mankhwala olimbana ndi BRAF kinase inhibitor (dabrafenib) kuphatikiza ndi MEK inhibitor (trametinib), ya zotupa zina zomwe sizingachotsedwe ndi opaleshoni.

Chithandizo cha ubongo chimayambira glioma mwa ana omwe ali ndi neurofibromatosis mtundu wa 1 atha kuwonedwa. Zotupazo zikukula pang'onopang'ono mwa ana awa ndipo mwina sizingafunike chithandizo chapadera kwa zaka zambiri.

Kuchiza kwa Brain Stem Glioma Yopita Patsogolo

Khansa ikapanda kuchira kapena kubwerera, chisamaliro chothandizira ndi gawo lofunikira pamakonzedwe amwana. Zimaphatikizapo kuthandizira thupi, malingaliro, chikhalidwe, komanso zauzimu kwa mwana ndi banja. Cholinga cha chisamaliro chothandizira ndikuthandizira kuwongolera zizindikiritso ndikupatsa mwanayo moyo wabwino kwambiri. Makolo sangakhale otsimikiza zakuti apitilize kulandira chithandizo kapena mtundu wa mankhwala omwe ndi abwino kwa mwana wawo. Gulu lazachipatala lingapatse makolo chidziwitso chowathandiza kupanga zisankhozi.

Mankhwala owonjezera ma radiation amatha kuperekedwa kwa ana omwe ali ndi pontine glioma (DIPG) omwe amapitilira pang'onopang'ono kapena obwereza omwe amayankha akalandira chithandizo chama radiation. Chithandizo cha DIPG chopitilira kapena chobwereza chikhoza kuphatikizanso izi:

• Kuyesedwa kwachipatala komwe kumayang'ana chotupa cha wodwalayo ngati majini ena asintha. Mtundu wa mankhwala omwe akulimbikitsidwa omwe adzapatsidwe kwa wodwala umadalira mtundu wa kusintha kwa majini.

• Kuyesedwa kwachipatala kwa mankhwala omwe ali ndi histone deacetylase inhibitor (panobinostat) kapena antiococonal antibody (APX005M).

Chithandizo cha ubongo womwe umayambitsa ubongo wa glioma ungaphatikizepo izi:

• Kuchita opaleshoni yachiwiri kuchotsa chotupacho.

• Thandizo la radiation lakunja.

• Chemotherapy.

• Kuyesedwa kwachipatala komwe kumayang'ana chotupa cha wodwalayo ngati majini ena asintha. Mtundu wa mankhwala omwe akulimbikitsidwa omwe adzapatsidwe kwa wodwala umadalira mtundu wa kusintha kwa majini.

Kuti mudziwe Zambiri Zotupa za Ubongo Waubwana

Kuti mumve zambiri zamatenda amubongo aubwana, onani izi:

• Matenda a Ubongo Tumor Consortium (PBTC) Tulukani Chodzikanira

• Kuyankhulana pa Kusamalira Khansa

• Kukonzekera Kusintha Kwa Kutha-Kwa-Moyo Kusamalira Khansa Yapamwamba

• Thandizo Lothandizira Ana (Kutha kwa Kusamalira Moyo)

Kuti mumve zambiri za khansa yaubwana ndi zina zothandiza za khansa, onani izi:

• Za Khansa

• Khansa Za Ana

• Cure Search for Cancer ya Ana Tulukani Chodzikanira

• Zotsatira Zochedwetsa Khansa Yaana

• Achinyamata ndi Achinyamata Achikulire ndi Khansa

• Ana omwe ali ndi khansa: Upangiri wa Makolo

• Khansa mwa Ana ndi Achinyamata

• Kusinthana

• Kulimbana ndi khansa

• Mafunso oti mufunse dokotala wanu za khansa

• Kwa Opulumuka ndi Owasamalira