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Osteosarcoma ndi Malignant Fibrous Histiocytoma of Bone Treatment (®) -Patient Version

Zambiri Zokhudza Osteosarcoma ndi Malignant Fibrous Histiocytoma of Bone

MFUNDO ZOFUNIKA

• Osteosarcoma ndi malignant fibrous histiocytoma (MFH) a mafupa ndi matenda omwe ma cell owopsa (khansa) amapangika m'mafupa.

• Kukhala ndi chithandizo cham'mbuyomu ndi radiation kumatha kuwonjezera chiopsezo cha osteosarcoma.

• Zizindikiro za osteosarcoma ndi MFH zimaphatikizapo kutupa pa fupa kapena gawo la mafupa amthupi komanso kupweteka kwamagulu.

• Kuyesa kuyerekezera kumagwiritsidwa ntchito kupeza (kupeza) osteosarcoma ndi MFH.

• Chidziwitso chimachitika kuti muzindikire osteosarcoma.

• Zinthu zina zimakhudzanso madandaulo (mwayi wochira) ndi njira zamankhwala.

Osteosarcoma ndi malignant fibrous histiocytoma (MFH) a mafupa ndi matenda omwe ma cell owopsa (khansa) amapangika m'mafupa.

Osteosarcoma nthawi zambiri imayamba mu ma osteoblasts, omwe ndi mtundu wa mafupa omwe amakhala mafupa atsopano. Osteosarcoma imakonda kwambiri achinyamata. Amakonda kupanga kumapeto kwa mafupa aatali a thupi, omwe amaphatikizapo mafupa a mikono ndi miyendo. Kwa ana ndi achinyamata, nthawi zambiri amapangika m'mafupa ataliatali, pafupi ndi bondo. Kawirikawiri, osteosarcoma imapezeka m'matumba ofewa kapena ziwalo m'chifuwa kapena m'mimba.

Osteosarcoma ndiye khansa yapafupa yofala kwambiri. Malignant fibrous histiocytoma (MFH) ya fupa ndi chotupa chosowa cha fupa. Amachiritsidwa ngati osteosarcoma.

Ewing sarcoma ndi mtundu wina wa khansa ya m'mafupa, koma sikunaphatikizidwe mwachidule. Onani chidule cha chokhudza Ewing Sarcoma Treatment kuti mumve zambiri.

Kukhala ndi chithandizo cham'mbuyomu ndi radiation kumatha kuwonjezera chiopsezo cha osteosarcoma.

Chilichonse chomwe chimakulitsa chiopsezo chotenga matenda chimatchedwa chiopsezo. Kukhala ndi chiwopsezo sikutanthauza kuti udzakhala ndi khansa; kusakhala ndi zoopsa sikutanthauza kuti simudzakhala ndi khansa. Lankhulani ndi dokotala wa mwana wanu ngati mukuganiza kuti mwana wanu akhoza kukhala pachiwopsezo. Zowopsa za osteosarcoma ndi izi:

• Chithandizo cham'mbuyomu ndi mankhwala a radiation.

• Chithandizo cham'mbuyomu ndi mankhwala a anticancer omwe amatchedwa alkylating agents.

• Kukhala ndi kusintha kwina mumtundu wa RB1.

• Kukhala ndi zikhalidwe zina, monga izi:

• Matenda a Bloom.

• Kuchepa kwa magazi a Diamond-Blackfan.

• Matenda a Li-Fraumeni.

• Matenda a Paget.

• Cholowa retinoblastoma.

• Matenda a Rothmund-Thomson.

• Matenda a Werner.

Zizindikiro za osteosarcoma ndi MFH zimaphatikizapo kutupa pa fupa kapena gawo la mafupa amthupi komanso kupweteka kwamagulu.

Izi ndi zizindikilo ndi zina zimatha chifukwa cha osteosarcoma kapena MFH kapena zina. Funsani dokotala ngati mwana wanu ali ndi izi:

• Kutupa ndi fupa kapena mafupa mbali ya thupi.

• Ululu wa fupa kapena olowa.

• Fupa lomwe limathyoka popanda chifukwa chodziwika.

Kuyesa kuyerekezera kumagwiritsidwa ntchito kupeza (kupeza) osteosarcoma ndi MFH.

Kuyesa kuyesa kumachitika pasanachitike biopsy. Mayeso ndi njira zotsatirazi zitha kugwiritsidwa ntchito:

• Kuwunika kwakuthupi ndi mbiri: Kuyesedwa kwa thupi kuti muwone zizindikiritso zaumoyo, kuphatikiza kuyang'ana ngati pali matenda, monga zotupa kapena china chilichonse chomwe chikuwoneka chachilendo. Mbiri yokhudzana ndi thanzi la wodwalayo komanso matenda am'mbuyomu komanso chithandizo chamankhwala adzachitidwanso.

• X-ray: X-ray ya ziwalo ndi mafupa mkati mwa thupi. X-ray ndi mtundu wa mphamvu yamphamvu yomwe imatha kupyola thupi ndikupita mufilimu, ndikupanga chithunzi cha madera omwe ali mthupi.

• CT scan (CAT scan): Njira yomwe imapanga zithunzi zingapo zamatupi amthupi, zojambulidwa mosiyanasiyana. Zithunzizo zimapangidwa ndi kompyuta yolumikizidwa ndi makina a x-ray. Utoto ukhoza kulowetsedwa mumtsempha kapena kumeza kuti ziwalo kapena ziwalo ziwoneke bwino. Njirayi imatchedwanso computed tomography, kompyuta tomography, kapena kompyuta axial tomography.

• MRI (magnetic resonance imaging): Njira yomwe imagwiritsa ntchito maginito, mafunde a wailesi, ndi kompyuta kuti ipange zithunzi zingapo za malo amkati mwa thupi. Njirayi imatchedwanso nuclear magnetic resonance imaging (NMRI).

Chidziwitso chimachitika kuti muzindikire osteosarcoma.

Maselo ndi ziphuphu zimachotsedwa panthawi yomwe zimachitika kuti ziwoneke ndi microscope ndi wodwala kuti aone ngati ali ndi khansa. Ndikofunika kuti biopsy ichitike ndi dotolo yemwe ndi katswiri wothandizira khansa yapafupa. Ndi bwino ngati dokotalayo alinso amene amachotsa chotupacho. Biopsy ndi opareshoni yochotsa chotupacho zakonzedwa limodzi. Momwe kafukufukuyu amachitikira zimakhudza mtundu wanji wa opaleshoni yomwe ingachitike pambuyo pake.

Mtundu wa biopsy womwe wachitika utengera kukula kwa chotupacho komanso komwe kuli mthupi. Pali mitundu iwiri ya biopsy yomwe ingagwiritsidwe ntchito:

• Core biopsy: Kuchotsa minofu pogwiritsa ntchito singano yayikulu.

• Incopal biopsy: Kuchotsa gawo limodzi kapena mtundu wina wa minofu yomwe sikuwoneka bwino.

Mayeso otsatirawa atha kuchitidwa pamtundu womwe wachotsedwa:

• Electron microscopy: Kuyesa kwa labotale komwe ma cell amtundu wa minofu amawonedwa pansi pa maikulosikopu pafupipafupi komanso amphamvu kwambiri kuti apeze zosintha m'maselo.

Zinthu zina zimakhudzanso madandaulo (mwayi wochira) ndi njira zamankhwala.

Kulosera (mwayi wochira) kumakhudzidwa ndi zinthu zina asanalandire chithandizo komanso pambuyo pake.

Matenda a osteosarcoma osachiritsidwa ndi MFH zimadalira izi:

• Komwe chotupacho chili mthupi komanso ngati zotupa zimapangidwa m'mafupa opitilira umodzi.

• Kukula kwa chotupacho.

• Kaya khansara yafalikira mbali zina za thupi komanso kumene yafalikira.

• Mtundu wa chotupa (kutengera momwe ma cell a khansa amawonekera pansi pa microscope).

• Msinkhu ndi kulemera kwa wodwalayo panthawi yodziwika.

• Kaya wodwalayo adalandira khansa ina.

• Kaya chotupacho chachititsa kuti pakhale mafupa.

• Kaya wodwalayo ali ndi matenda ena amtundu.

Pambuyo pochiritsidwa osteosarcoma kapena MFH, kudwala kumadalira zotsatirazi:

• Khansa yochuluka bwanji idaphedwa ndi chemotherapy.

• Kuchuluka kwa chotupacho adachotsedwa ndi opaleshoni.

• Kaya khansara yabwereranso (yabwereranso) mkati mwa zaka 2 mutazindikira.

Njira zochiritsira osteosarcoma ndi MFH zimadalira izi:

• Komwe chotupacho chili mthupi.

• Kukula kwa chotupacho.

• Gawo ndi khansa.

• Kaya mafupa akukulabe.

• Msinkhu wa wodwalayo komanso thanzi lake lonse.

• Chokhumba cha wodwalayo ndi banja kuti wodwalayo athe kutenga nawo mbali pazochitika monga masewera kapena kuwoneka mwanjira inayake.

• Kaya khansa yapezeka kumene kapena yabwereranso atalandira chithandizo.

Magawo a Osteosarcoma ndi Malignant Fibrous Histiocytoma of Bone

MFUNDO ZOFUNIKA

• Pambuyo pa matenda a osteosarcoma kapena malignant fibrous histiocytoma (MFH), mayesero amachitika kuti apeze ngati maselo a khansa afalikira mbali zina za thupi.

• Pali njira zitatu zomwe khansa imafalikira mthupi.

• Khansa imatha kufalikira pomwe idayamba kupita mbali zina za thupi.

• Osteosarcoma ndi MFH amafotokozedwa kuti ndi am'deralo kapena a metastatic.

Pambuyo pa matenda a osteosarcoma kapena malignant fibrous histiocytoma (MFH), mayesero amachitika kuti apeze ngati maselo a khansa afalikira mbali zina za thupi.

Njira yomwe imagwiritsidwa ntchito pofufuza ngati khansa yafalikira mbali zina za thupi imatchedwa staging. Kwa osteosarcoma ndi malignant fibrous histiocytoma (MFH), odwala ambiri amakhala m'magulu malinga ndi momwe khansa imapezeka m'chigawo chimodzi chokha cha thupi (komwe kuli) kapena yafalikira (metastatic).

Mayeso ndi njira zotsatirazi zitha kugwiritsidwa ntchito:

• X-ray: X-ray ya ziwalo, monga chifuwa, ndi mafupa mkati mwa thupi. X-ray ndi mtundu wa mphamvu yamphamvu yomwe imatha kupyola thupi ndikupita mufilimu, ndikupanga chithunzi cha madera omwe ali mthupi. Ma X-ray adzatengedwa pachifuwa ndi dera lomwe chotupacho chinapangidwira.

• CT scan (CAT scan): Njira yomwe imapanga zithunzi zingapo zamkati mwa thupi, monga chifuwa, zojambulidwa mosiyanasiyana. Zithunzizo zimapangidwa ndi kompyuta yolumikizidwa ndi makina a x-ray. Utoto ukhoza kulowetsedwa mumtsempha kapena kumeza kuti ziwalo kapena ziwalo ziwoneke bwino. Njirayi imatchedwanso computed tomography, kompyuta tomography, kapena kompyuta axial tomography. Zithunzi zidzatengedwa pachifuwa ndi dera lomwe chotupacho chidapangidwa.

• PET-CT scan: Njira yophatikiza zithunzizo kuchokera pa sikani ya positron emission tomography (PET) ndi scan computed tomography (CT). Kujambula kwa PET ndi CT kumachitika nthawi yomweyo pamakina omwewo. Zithunzi zojambulidwa zonsezi zimaphatikizidwa kuti apange chithunzi chatsatanetsatane kuposa momwe mayeso angapangire mwa iwo okha. Kujambula kwa PET ndi njira yopezera maselo oyipa amthupi. Gulu laling'ono la shuga (radio) limabayidwa mumtsempha. Chojambulira cha PET chimazungulira thupi ndikupanga chithunzi cha komwe glucose imagwiritsidwa ntchito mthupi. Maselo otupa owopsa amawonekera pachithunzichi chifukwa amakhala otanganidwa ndipo amatenga shuga wambiri kuposa momwe maselo amachitira.

• MRI (magnetic resonance imaging): Njira yomwe imagwiritsa ntchito maginito, mafunde a wailesi, ndi kompyuta kuti ipange zithunzi zingapo za malo amkati mwa thupi. Njirayi imatchedwanso nuclear magnetic resonance imaging (NMRI).

• Kujambula mafupa: Njira yowunika ngati pali magawo omwe amagawa mwachangu, monga maselo a khansa, m'mafupa. Katundu wocheperako kwambiri wa jakisoni amalowetsedwa mumtsempha ndikuyenda m'magazi. Zinthu zowononga nyukiliya zimasonkhanitsa m'mafupa omwe ali ndi khansa ndipo imadziwika ndi sikani.

Pali njira zitatu zomwe khansa imafalikira mthupi.

Khansa imatha kufalikira kudzera mu minofu, ma lymph system, ndi magazi:

• Minofu. Khansara imafalikira kuchokera pomwe idayamba ndikukula kupita kumadera oyandikana nawo.

• Lymph dongosolo. Khansara imafalikira kuchokera pomwe idayamba polowa m'mitsempha. Khansara imadutsa m'mitsempha yamafuta kupita mbali zina za thupi.

• Magazi. Khansara imafalikira kuchokera pomwe idayamba ndikulowa m'magazi. Khansara imadutsa m'mitsempha yamagazi kupita mbali zina za thupi.

Khansa imatha kufalikira pomwe idayamba kupita mbali zina za thupi.

Khansa ikafalikira mbali ina ya thupi, imatchedwa metastasis. Maselo a khansa amachoka pomwe adayamba (chotupa choyambirira) ndikuyenda mumitsempha kapena magazi.

• Lymph dongosolo. Khansara imalowa mumitsempha, imadutsa m'mitsempha yamafuta, ndikupanga chotupa (chotupa cha metastatic) gawo lina la thupi.

• Magazi. Khansara imalowa m'magazi, imadutsa m'mitsempha yamagazi, ndikupanga chotupa (chotupa cha metastatic) gawo lina la thupi.

Chotupa cha metastatic ndi khansa yofanana ndi chotupa chachikulu. Mwachitsanzo, ngati osteosarcoma imafalikira m'mapapu, maselo a khansa m'mapapu alidi maselo a osteosarcoma. Matendawa ndi metastatic osteosarcoma, osati khansa yamapapo.

Osteosarcoma ndi MFH amafotokozedwa kuti ndi am'deralo kapena a metastatic.

• Matenda a osteosarcoma kapena MFH sanatulukire m'mafupa pomwe khansa idayambira. Pakhoza kukhala gawo limodzi kapena angapo a khansa m'mafupa omwe amatha kuchotsedwa pakuchita opaleshoni.

• Metastatic osteosarcoma kapena MFH yafalikira kuchokera ku fupa pomwe khansa idayamba kupita mbali zina za thupi. Khansara imafalikira m'mapapu. Ikhozanso kufalikira kumafupa ena.

Osteosarcoma ndi Malignant Fibrous Histiocytoma a Bone

Matenda a osteosarcoma ndi malignant fibrous histiocytoma (MFH) a mafupa ndi khansa yomwe yabwereranso (kubwerera) itachiritsidwa. Khansara imatha kubwerera m'mafupa kapena mbali zina za thupi. Osteosarcoma ndi MFH nthawi zambiri zimabwereranso m'mapapu, fupa, kapena zonse ziwiri. Pamene osteosarcoma imabwereranso, nthawi zambiri imakhala mkati mwa miyezi 18 chithandizo chitamalizidwa.

Chithandizo Chosankha Mwachidule

MFUNDO ZOFUNIKA

• Pali mitundu yosiyanasiyana ya chithandizo cha odwala omwe ali ndi osteosarcoma kapena malignant fibrous histiocytoma (MFH) ofupa.

• Ana omwe ali ndi osteosarcoma kapena MFH ayenera kukonzekera chithandizo chawo ndi gulu la othandizira azaumoyo omwe ndi akatswiri othandiza khansa kwa ana.

• Kuchiza kwa osteosarcoma kapena malignant fibrous histiocytoma kumatha kuyambitsa zovuta.

• Mitundu isanu yamankhwala amtundu uliwonse imagwiritsidwa ntchito:

• Opaleshoni

• Chemotherapy

• Thandizo la radiation

• Samarium

• Chithandizo chofuna

• Mitundu yatsopano yamankhwala ikuyesedwa m'mayesero azachipatala.

• Odwala angaganize zopita nawo kukayezetsa.

• Odwala amatha kulowa m'mayesero azachipatala asanayambe, asanayambe, kapena atayamba kulandira chithandizo cha khansa.

• Mayeso otsatirawa angafunike.

Pali mitundu yosiyanasiyana ya chithandizo cha odwala omwe ali ndi osteosarcoma kapena malignant fibrous histiocytoma (MFH) ofupa.

Mankhwala osiyanasiyana amapezeka kwa ana omwe ali ndi osteosarcoma kapena malignant fibrous histiocytoma (MFH) ofupa. Mankhwala ena ndi ofanana (mankhwala omwe akugwiritsidwa ntchito pano), ndipo ena akuyesedwa m'mayesero azachipatala. Kuyesedwa kwachipatala ndi kafukufuku wofufuza wothandizira kusintha chithandizo chamakono kapena kupeza zidziwitso zamankhwala atsopano kwa odwala khansa. Pamene mayesero azachipatala awonetsa kuti chithandizo chatsopano ndichabwino kuposa chithandizo chamankhwala, chithandizocho chitha kukhala chamankhwala wamba.

Chifukwa khansa mwa ana ndiyosowa, kutenga nawo mbali pakuyesa kwachipatala kuyenera kuganiziridwa. Mayesero ena azachipatala ndi otseguka kwa odwala omwe sanayambe kulandira chithandizo.

Ana omwe ali ndi osteosarcoma kapena MFH ayenera kukonzekera chithandizo chawo ndi gulu la othandizira azaumoyo omwe ndi akatswiri othandiza khansa kwa ana.

Chithandizo chidzayang'aniridwa ndi oncologist wa ana, dokotala yemwe amadziwika bwino pochiza ana omwe ali ndi khansa. Ocologist wa ana amagwira ntchito ndi othandizira ena othandizira zaumoyo omwe ndi akatswiri pochiza osteosarcoma ndi MFH komanso omwe amadziwika bwino pamankhwala ena. Izi zingaphatikizepo akatswiri awa:

• Dokotala wa ana.

• Dokotala wa mafupa yemwe akudziwa bwino zotupa mafupa.

• Wofufuza oncologist.

• Katswiri wokonzanso.

• Katswiri wa namwino wa ana.

• Wogwira ntchito.

• Katswiri wa moyo wa ana.

• Katswiri wa zamaganizo.

Kuchiza kwa osteosarcoma kapena malignant fibrous histiocytoma kumatha kuyambitsa zovuta.

Kuti mumve zambiri zamankhwala oyambilira omwe amayamba mukalandira chithandizo cha khansa, onani tsamba lathu la Zotsatira Zotsatira.

Zotsatira zoyipa za mankhwala a khansa omwe amayamba atalandira chithandizo ndikupitilira kwa miyezi kapena zaka amatchedwa zotsatira zakuchedwa. Zotsatira zakumapeto kwa chithandizo cha khansa zitha kuphatikizira izi:

• Mavuto athupi.

• Kusintha kwa malingaliro, malingaliro, kuganiza, kuphunzira, kapena kukumbukira.

• Khansa yachiwiri (mitundu yatsopano ya khansa).

Zotsatira zina mochedwa zimatha kuthandizidwa kapena kuwongoleredwa. Ndikofunika kulankhula ndi madotolo a mwana wanu zamankhwala omwe khansa imatha kukhala nawo pamwana wanu. (Onani chidule cha pa Zotsatira Zotsiriza za Chithandizo cha Khansa ya Ana kuti mumve zambiri).

Mitundu isanu yamankhwala amtundu uliwonse imagwiritsidwa ntchito:

Opaleshoni

Opaleshoni yochotsa chotupa chonsecho idzachitika ngati zingatheke. Chemotherapy imatha kuperekedwa asanachite opaleshoni kuti chotupacho chikhale chocheperako. Izi zimatchedwa neoadjuvant chemotherapy. Chemotherapy imaperekedwa kotero kuti mafupa ochepa amafunika kuchotsedwa ndipo pamakhala zovuta zochepa pambuyo pochitidwa opaleshoni.

Mitundu yotsatirayi ingachitike:

• Kudandaula kwina konse: Kuchita opaleshoni kuti muchotse khansayo komanso minofu yabwinobwino poizungulira.

• Kuchita opaleshoni yopulumutsa ziwalo: Kuchotsa chotupa mu chiwalo (dzanja kapena mwendo) osadulidwa, kotero kuti ntchito ndi mawonekedwe a chiwalocho zimasungidwa. Odwala ambiri omwe ali ndi osteosarcoma mu chiwalo amatha kuchiritsidwa ndi opaleshoni yopulumutsa ziwalo. Chotupacho chimachotsedwa chifukwa chodula komweko. Minofu ndi mafupa omwe amachotsedwa amatha kulowetsedwa m'malo olumikizidwa ndi minofu ndi mafupa otengedwa kuchokera ku gawo lina la thupi la wodwalayo, kapena ndi choikapo monga fupa lopangira. Ngati wovulala amapezeka panthawi yomwe amapezeka kapena atalandira mankhwala a chemotherapy asanachite opareshoni, opareshoni yopulumutsa ziwalo amatha kukhalabe otheka nthawi zina. Ngati dokotalayo sangathe kuchotsa chotupacho ndi minofu yathanzi yokwanira mozungulira, akhoza kudulidwa.

• Kudulidwa: Kuchita opaleshoni kuchotsa gawo kapena mkono kapena mwendo wonse. Izi zitha kuchitika ngati sizingatheke kuchotsa chotupa chonse cha opareshoni yopulumutsa ziwalo. Wodwalayo atha kudzozedwapo (chiwalo chopangira) atadulidwa.

• Rotationplasty: Opaleshoni kuti achotse chotupacho ndi mawondo. Gawo la mwendo lomwe limatsalira pansi pa bondo limalumikizidwa ndi gawo la mwendo lomwe limatsalira pamwamba pa bondo, phazi likuyang'ana chakumbuyo ndipo bondo likuchita ngati bondo. Kenako amatha kulumikizanso phazi.

Kafukufuku akuwonetsa kuti kupulumuka ndikofanana ngakhale opaleshoni yoyamba yomwe yachitika ndikuchita opaleshoni yopulumutsa ziwalo kapena kudulidwa.

Dokotala atachotsa khansa yonse yomwe imawonekera panthawi yochitidwa opaleshoniyi, odwala amapatsidwa chemotherapy kuti aphe maselo aliwonse a khansa omwe atsala m'dera lomwe chotupacho chidachotsedwa kapena chomwe chafalikira mbali zina za thupi. Chithandizo chomwe chimaperekedwa pambuyo pa opareshoni, kuti muchepetse chiopsezo kuti khansa ibwererenso, amatchedwa adjuvant therapy.

Chemotherapy

Chemotherapy ndi mankhwala a khansa omwe amagwiritsa ntchito mankhwala oletsa kukula kwa maselo a khansa, mwina popha ma cell kapena kuwaletsa kuti asagawane. Chemotherapy ikamamwa pakamwa kapena kulowetsedwa mumtsempha kapena minofu, mankhwalawa amalowa m'magazi ndipo amatha kufikira ma cell a khansa mthupi lonse (systemic chemotherapy). Chemotherapy ikaikidwa molunjika m'matumbo a cerebrospinal, chiwalo, kapena thupi ngati pamimba, mankhwalawa amakhudza kwambiri ma cell a khansa m'malo amenewo (chemotherapy am'madera).

Mgwirizano wa chemotherapy ndi kugwiritsa ntchito mankhwala opatsirana angapo opatsirana khansa.

Mankhwala amtundu wa chemotherapy amagwiritsidwa ntchito pochiza osteosarcoma ndi MFH of bone. Chemotherapy nthawi zambiri amapatsidwa asanachite opaleshoni kapena pambuyo pake kuti achotse chotupacho.

Onani Mankhwala Ovomerezeka a Khansa Yam'mafupa kuti mumve zambiri.

Thandizo la radiation

Thandizo la radiation ndi chithandizo cha khansa chomwe chimagwiritsa ntchito ma x-ray amphamvu kapena mitundu ina ya radiation kuti iphe ma cell a khansa kapena kuti asakule. Pali mitundu iwiri ya mankhwala a radiation:

• Mankhwala ochiritsira akunja amagwiritsa ntchito makina kunja kwa thupi kuti atumize cheza chaku khansa.

• Njira yothandizira poizoniyu yamkati imagwiritsa ntchito mankhwala a radioactive otsekedwa ndi singano, njere, mawaya, kapena ma catheters omwe amayikidwa mwachindunji kapena pafupi ndi khansa.

Thandizo la radiation lakunja limagwiritsidwa ntchito pochiza osteosarcoma ndi MFH of bone.

Maselo a Osteosarcoma ndi MFH samaphedwa mosavuta ndi mankhwala ochokera kunja kwa radiation. Itha kugwiritsidwa ntchito khansa yochepa itasiyidwa pambuyo pochitidwa opaleshoni kapena kugwiritsidwa ntchito limodzi ndi mankhwala ena.

Samarium

Samarium ndi mankhwala osokoneza bongo omwe amayang'ana madera omwe mafupa amakulira, monga zotupa m'mafupa. Zimathandiza kuthetsa ululu womwe umayambitsidwa ndi khansa m'mafupa komanso imapha ma cell am'mafupa. Amagwiritsidwanso ntchito pochiza osteosarcoma yomwe yabwerera pambuyo pochiritsidwa mufupa lina.

Chithandizo cha samarium chitha kutsatiridwa ndi kuphatika kwa cell cell. Asanapatsidwe chithandizo ndi samarium, maseli am'magazi (maselo osakhazikika amwazi) amachotsedwa m'magazi kapena m'mafupa a wodwalayo ndipo amawundana ndikusungidwa. Pambuyo pa chithandizo cha samarium chatha, maselo osungidwa amasungunuka ndi kubwezeredwa kwa wodwalayo kudzera pakulowetsedwa. Maselo amtundu wobwezeretsansowa amakula (ndikubwezeretsanso) maselo amthupi.

Chithandizo chofuna

Chithandizo chomwe mukufuna ndi chithandizo chomwe chimagwiritsa ntchito mankhwala osokoneza bongo kapena zinthu zina kuti mupeze ndikuwononga ma cell amtundu wina wa khansa osavulaza maselo abwinobwino. Pali mitundu yosiyanasiyana ya mankhwala omwe akugwiritsidwa ntchito pochiza osteosarcoma kapena kuphunzira m'mayesero azachipatala:

• Kinase inhibitor therapy imatseka puloteni yofunikira kuti maselo a khansa agawanike. Sorafenib ndi mtundu wa kinase inhibitor mankhwala omwe amagwiritsidwa ntchito pochiza osteosarcoma.

• Cholinga cha mamalia cha rapamycin (mTOR) chimalepheretsa puloteni yotchedwa mTOR, yomwe imalepheretsa maselo a khansa kukula ndikuletsa kukula kwa mitsempha yatsopano yomwe zotupa zimayenera kukula. Everolimus ndi mTOR inhibitor yomwe imagwiritsidwa ntchito pochiza osteosarcoma.

• Thandizo la monoclonal antibody ndi khansa yomwe imagwiritsa ntchito ma antibodies opangidwa mu labotore, kuchokera ku mtundu umodzi wamatenda amthupi. Ma antibodies awa amatha kuzindikira zinthu zomwe zili m'maselo a khansa kapena zinthu zabwinobwino zomwe zingathandize ma cell a khansa kukula. Ma antibodies amalumikizana ndi zinthuzo ndikupha ma cell a khansa, amalepheretsa kukula kwawo, kapena amalepheretsa kufalikira. Ma antibodies a monoclonal amaperekedwa mwa kulowetsedwa. Angagwiritsidwe ntchito okha kapena kunyamula mankhwala osokoneza bongo, poizoni, kapena zinthu zowononga radio kupita kuma cell a khansa. Denosumab ndi dinutuximab ndi ma anti-monoclonal antibodies omwe amaphunziridwa pochiza osteosarcoma.

Mitundu yatsopano yamankhwala ikuyesedwa m'mayesero azachipatala.

Zambiri zamayesero azachipatala omwe akupitilira amapezeka patsamba la NCI.

Odwala angaganize zopita nawo kukayezetsa.

Kwa odwala ena, kutenga nawo mbali pakuyesa chithandizo chachipatala kungakhale njira yabwino kwambiri yothandizira. Mayesero azachipatala ndi gawo limodzi la kafukufuku wa khansa. Mayesero azachipatala amachitika kuti apeze ngati mankhwala atsopano a khansa ndi otetezeka komanso ogwira ntchito kapena abwinoko kuposa mankhwala wamba.

Njira zambiri zamankhwala zochiritsira khansa zimachokera kumayeso am'mbuyomu azachipatala. Odwala omwe amatenga nawo mbali pachipatala atha kulandira chithandizo chofananira kapena kukhala oyamba kulandira chithandizo chatsopano.

Odwala omwe amatenga nawo mbali pazoyeserera zamankhwala amathandizanso kukonza momwe khansa idzathandizire mtsogolo. Ngakhale mayesero azachipatala satsogolera kuchipatala chatsopano, nthawi zambiri amayankha mafunso ofunikira ndikuthandizira kupititsa patsogolo kafukufuku.

Odwala amatha kulowa m'mayesero azachipatala asanayambe, asanayambe, kapena atayamba kulandira chithandizo cha khansa.

Mayesero ena azachipatala amangophatikizapo odwala omwe sanalandire chithandizo. Mayesero ena amayesa chithandizo kwa odwala omwe khansa yawo sinakhale bwino. Palinso mayesero azachipatala omwe amayesa njira zatsopano zothetsera khansa kuti isabwererenso (kubwerera) kapena kuchepetsa zovuta zoyambitsidwa ndi khansa.

Mayesero azachipatala akuchitika m'malo ambiri mdziko muno. Zambiri zamayeso azachipatala othandizidwa ndi NCI zitha kupezeka patsamba lofufuza zamankhwala la NCI. Mayesero azachipatala othandizidwa ndi mabungwe ena amapezeka patsamba la ClinicalTrials.gov.

Mayeso otsatirawa angafunike.

Ena mwa mayesero omwe adachitika kuti apeze khansa kapena kuti adziwe momwe khansa iliri angabwerezedwenso. Mayesero ena adzabwerezedwa kuti awone momwe mankhwalawa akugwirira ntchito. Zisankho zakuti mupitilize, kusintha, kapena kusiya kulandira chithandizo zitha kutengera zotsatira za mayeso awa.

Kuyesaku kumangopitilira kuchitika nthawi ndi nthawi mankhwala atatha. Zotsatira zamayesowa zitha kuwonetsa ngati matenda a mwana wanu asintha kapena ngati khansa yabwereranso (kubwerera). Mayesowa nthawi zina amatchedwa kuyesa kutsata kapena kukayezetsa.

Njira Zothandizira Kuchiza Osteosarcoma ndi Malignant Fibrous Histiocytoma ya Bone

M'chigawo chino

• Osteosarcoma ndi Malignant Fibrous Histiocytoma a Bone

• Metastatic Osteosarcoma ndi Malignant Fibrous Histiocytoma ya Bone

• Osteosarcoma ndi Malignant Fibrous Histiocytoma a Bone

Kuti mumve zambiri zamankhwala omwe atchulidwa pansipa, onani gawo la Chisankho Chachidule.

Osteosarcoma ndi Malignant Fibrous Histiocytoma a Bone

Chithandizo chingaphatikizepo izi:

• Opaleshoni yochotsa chotupa choyambirira.

• Chemotherapy imatha kuperekedwa musanachite opaleshoni kapena pambuyo pake kuti muchotse chotupacho.

• Thandizo la radiation ngati opaleshoni singachitike kapena ngati chotupacho sichinachotsedwe kwathunthu ndi opaleshoni.

Gwiritsani ntchito kusaka kwathu kwamankhwala kuti mupeze mayesero azachipatala omwe amathandizidwa ndi NCI omwe akulandira odwala. Mutha kusaka mayesero kutengera mtundu wa khansa, zaka za wodwalayo, komanso komwe mayeserowo akuchitika. Zambiri pazokhudza mayesero azachipatala zimapezekanso.

Metastatic Osteosarcoma ndi Malignant Fibrous Histiocytoma ya Bone

Mapapo Metastasis

Pamene osteosarcoma kapena malignant fibrous histiocytoma (MFH) imafalikira, imafalikira m'mapapu. Chithandizo cha osteosarcoma ndi MFH ndi metastasis yamapapo ingaphatikizepo izi:

• Chemotherapy yotsatira ndi opaleshoni kuchotsa khansa yoyamba komanso khansa yomwe yafalikira m'mapapu.

Bone Metastasis kapena Bone yokhala ndi Lung Metastasis

Osteosarcoma ndi malignant fibrous histiocytoma imafalikira mpaka fupa lakutali ndi / kapena mapapo. Chithandizo chingaphatikizepo izi:

• Chemotherapy yotsatira ndi opaleshoni kuchotsa chotupa choyambirira ndi khansa yomwe yafalikira mbali zina za thupi. Chemotherapy yambiri imaperekedwa pambuyo pa opaleshoni.

• Kuchita opaleshoni kuchotsa chotupa choyambirira, kenako chemotherapy ndi opaleshoni kuchotsa khansa yomwe yafalikira mbali zina za thupi.

Gwiritsani ntchito kusaka kwathu kwamankhwala kuti mupeze mayesero azachipatala omwe amathandizidwa ndi NCI omwe akulandira odwala. Mutha kusaka mayesero kutengera mtundu wa khansa, zaka za wodwalayo, komanso komwe mayeserowo akuchitika. Zambiri pazokhudza mayesero azachipatala zimapezekanso.

Osteosarcoma ndi Malignant Fibrous Histiocytoma a Bone

Chithandizo cha matenda obwereza a osteosarcoma ndi malignant fibrous histiocytoma of bone atha kukhala awa:

• Kuchita opaleshoni kuti muchotse khansa yomwe yafalikira mbali zina za thupi.

• Chemotherapy.

• Kwa zotupa zomwe zabwereranso m'mafupa okha, samarium yopanda kapena yopanda tsinde pogwiritsa ntchito maselo am'maso a wodwalayo, monga chithandizo chothandizira kuchepetsa ululu ndikusintha moyo.

• Chithandizo choyenera (sorafenib kapena everolimus).

• Thandizo la radiation ngati mankhwala ochepetsa nkhawa kuti athetseretu kusintha komanso kukhala ndi moyo wabwino.

• Kuyesedwa kwachipatala komwe kumayang'ana chotupa cha wodwalayo ngati majini ena asintha. Mtundu wa mankhwala omwe akulimbikitsidwa omwe adzapatsidwe kwa wodwala umadalira mtundu wa kusintha kwa majini.

• Kuyesedwa kwamankhwala kwamitundu yatsopano yamankhwala kwa odwala omwe khansa yawo singathe kuchotsedwa ndi opaleshoni. Izi zitha kuphatikizira chithandizo chamankhwala monga monoclonal antibody therapy.

Gwiritsani ntchito kusaka kwathu kwamankhwala kuti mupeze mayesero azachipatala omwe amathandizidwa ndi NCI omwe akulandira odwala. Mutha kusaka mayesero kutengera mtundu wa khansa, zaka za wodwalayo, komanso komwe mayeserowo akuchitika. Zambiri pazokhudza mayesero azachipatala zimapezekanso.

Kuti mudziwe zambiri za Osteosarcoma ndi Malignant Fibrous Histiocytoma of Bone

Kuti mumve zambiri kuchokera ku National Cancer Institute yokhudza osteosarcoma ndi malignant fibrous histiocytoma of bone, onani izi:

• Tsamba Loyambira Khansa Yam'mafupa

• Computed Tomography (CT) Zithunzi ndi Khansa

• Mankhwala Ovomerezeka a Khansa Yam'mafupa

• Njira Zochizira Khansa

• Khansa Yam'mafupa

Kuti mumve zambiri za khansa yaubwana ndi zina zothandiza za khansa, onani izi:

• Za Khansa

• Khansa Za Ana

• Cure Search for Cancer ya Ana Tulukani Chodzikanira

• Zotsatira Zochedwetsa Khansa Yaana

• Achinyamata ndi Achinyamata Achikulire ndi Khansa

• Ana omwe ali ndi khansa: Upangiri wa Makolo

• Khansa mwa Ana ndi Achinyamata

• Kusinthana

• Kulimbana ndi khansa

• Mafunso oti mufunse dokotala wanu za khansa

• Kwa Opulumuka ndi Owasamalira