Pafupifupi-khansa / chithandizo / mayesero azachipatala / testicular-khansa
Mayeso Amatenda Othandizira Khansa Yama testicular
Mayesero 1-4 a 4
Nivolumab ndi Ipilimumab pochiza odwala omwe ali ndi zotupa zambiri
Gawo ili lachiwiri lachiyeso limafufuza nivolumab ndi ipilimumab pochiza odwala omwe ali ndi zotupa zochepa. Immunotherapy yokhala ndi ma monoclonal antibodies, monga nivolumab ndi ipilimumab, imatha kuthandizira chitetezo chamthupi kulimbana ndi khansa, ndipo imatha kusokoneza kuthekera kwa maselo otupa kukula ndikufalikira. Mlanduwu umalembetsa otenga nawo mbali m'magulu otsatirawa potengera izi: 1. Zotupa zam'mimba zam'mimbamo, zotupa m'mimba, nasopharynx: A) Squamous cell carcinoma yokhala ndi mphuno, sinus, ndi nasopharynx ndi trachea (kupatula khansa ya khosi, nasopharyngeal [NPC] , ndi squamous cell carcinoma ya mutu ndi khosi [SCCHN]) B) Adenocarcinoma ndi mitundu ina yammphuno, sinus, ndi nasopharynx (yotseka mpaka kuchuluka kwa 07/27/2018) 2. Zotupa zam'mimba zamatenda akulu am'matumbo (otsekedwa mpaka kuwonjezeranso 03 / 20/2018) 3. Matumbo amtundu wa salivary otupa pamutu ndi m'khosi, milomo, kum'mero, m'mimba, trachea ndi mapapo, bere ndi malo ena (otsekedwa mpaka okwanira) 4. Carcinoma yosadziwika ya thirakiti (GI) 5. Adenocarcinoma yokhala ndi m'matumbo ang'onoang'ono (otsekedwa mpaka opezekapo) 05/10/2018) 6. Squamous cell carcinoma yokhala ndimatenda osiyanasiyana a GI (m'mimba matumbo ang'ono, m'matumbo, m'matumbo, kapamba) (yotseka mpaka 10/17/2018) 7. Fibromixoma ndi low grade mucinous adenocarcinoma (pseudomixoma peritonei) ya zowonjezerazo ndi ovary (kutsekedwa mpaka kuwonjezerapo 03/20/2018) 8. Zotupa zambiri za pancreatic kuphatikiza acinar cell carcinoma, mucinous cystadenocarcinoma kapena serous cystadenocarcinoma. Pancreatic adenocarcinoma siyoyenera 9. Intrahepatic cholangiocarcinoma (yotseka mpaka kuchuluka kwa 03/20/2018) 10. Extrahepatic cholangiocarcinoma ndi zotupa za bile (zotsekedwa mpaka kuwonjezeka 03/20/2018) 11. Sarcomatoid carcinoma ya m'mapapo 12. Bronchoalveolar carcinoma lung. Matendawa amadziwikanso kuti adenocarcinoma in situ, adenocarcinoma yocheperako, adenocarcinoma, kapena adidocarcinoma 13. Wotupa wa ovary B: A) Chifuwa cha khungu la ovary B) chotupa chosakanikirana ndi adenosarcoma (chatsekedwa chatsekedwa) mpaka kuwonjezeka 03/30/2018) 14. Chotupa cha trophoblastic: A) Choriocarcinoma (yotsekedwa mpaka kuwonjezeka) 15. Transitional cell carcinoma kupatula ya impso, m'chiuno, ureter, kapena chikhodzodzo (yotsekedwa mpaka kuwonjezeka) 16. Chotupa cha khungu ma testes ndi zotupa za majeremusi a extragonadal: A) Seminoma ndi khansa yam'mimba yamatumbo B) Chotupa chopanda semina C) Teratoma yosintha koopsa (kutsekedwa mpaka kuwonjezeka) 17.
Malo: malo 895
Kuyang'anitsitsa, Bleomycin, Carboplatin, Etoposide, kapena Cisplatin pochiza Odwala ndi Achikulire Odwala omwe ali ndi zotupa zamagulu a germ Gawo ili lachitatu lakuyesa momwe kuyang'anira, bleomycin, carboplatin, etoposide, kapena cisplatin zimagwirira ntchito pochiza odwala ndi achikulire omwe ali ndi zotupa za majeremusi. . Kuyang'anitsitsa mwachidwi kumatha kuthandiza madotolo kuwunika anthu omwe ali ndi zotupa zochepa za majeremusi pambuyo poti chotupa chawo chachotsedwa. Mankhwala omwe amagwiritsidwa ntchito mu chemotherapy, monga bleomycin, carboplatin, etoposide, ndi cisplatin, amagwira ntchito m'njira zosiyanasiyana kuti achepetse kukula kwa maselo otupa, mwina popha ma cell, powalekanitsa kuti asagawike, kapena poletsa kufalikira. Malo: malo 460
Inotuzumab Ozogamicin ndi Post-Induction Chemotherapy pochiza Odwala omwe ali ndi chiwopsezo chachikulu B-ZONSE, Mixed Phenotype Acute Leukemia, ndi B-LLy
Gawo lachitatu lachiyeso limafufuza ngati inotuzumab ozogamicin idawonjezeredwa kuchipatala cha post-induction cha odwala omwe ali ndi High-Risk B-cell Acute Lymphoblastic Leukemia (B-ALL) imathandizira zotsatira. Chiyesochi chikuwunikiranso zotsatira za odwala omwe ali ndi phenotype acute leukemia (MPAL), ndi B-lymphoblastic lymphoma (B-LLy) akamalandira mankhwala Onse popanda inotuzumab ozogamicin. Inotuzumab ozogamicin ndi antioclonal antibody, yotchedwa inotuzumab, yolumikizidwa ndi mtundu wa chemotherapy wotchedwa calicheamicin. Inotuzumab amamangiriza ku maselo a khansa m'njira yolunjika ndikupereka calicheamicin kuti iwaphe. Mankhwala ena omwe amagwiritsidwa ntchito mu chemotherapy regimen, monga cyclophosphamide, cytarabine, dexamethasone, doxorubicin, daunorubicin, methotrexate, leucovorin, mercaptopurine, prednisone, thioguanine, vincristine, ndipo pegaspargase imagwira ntchito m'njira zosiyanasiyana kuletsa kukula kwa maselo a khansa, mwina pakupha ma cell, kuwaletsa kuti asagawane, kapena kuwaletsa kuti asafalikire. Mlanduwu uphunziranso zotsatira za odwala omwe ali ndi phenotype acute leukemia (MPAL) ndikufalitsa B lymphoblastic lymphoma (B-LLy) akagwidwa ndi chiopsezo chachikulu chemotherapy. Cholinga chachikulu cha phunziroli ndikumvetsetsa ngati kuwonjezera inotuzumab ozogamicin pamankhwala oyenera a chemotherapy amasunga kapena kukonza zotsatira mu High Risk B-cell Acute Lymphoblastic Leukemia (HR B-ALL). Gawo loyambirira la phunziroli limaphatikizapo magawo awiri oyamba azithandizo: Kupatsidwa ulemu ndi Kuphatikiza. Gawoli lisonkhanitsa zambiri za khansa ya m'magazi, komanso zotsatirapo za chithandizo choyambirira, kuti athe kugawa odwala m'magulu azachipatala ataphatikiza. Pa gawo lachiwiri la kafukufukuyu, odwala azilandira zotsala za chemotherapy (kukonza kwakanthawi I, kuchedwa kukulitsa, kukonza kwakanthawi II, kukonza), ndi odwala ena atapatsidwa mwayi wopeza inotuzumab. Zolinga zina za kafukufukuyu zikuphatikiza kufufuza ngati kuwachiritsa amuna ndi akazi nthawi yofanana ya chemotherapy kumathandizira zomwe amuna omwe amalandilirako chaka chowonjezera poyerekeza ndi atsikana, komanso kuwunika njira zabwino zothandizira odwala kutsatira pakamwa mankhwala a chemotherapy. Pomaliza, kafukufukuyu adzakhala woyamba kutsatira zotsatira za maphunziro omwe afalitsidwa ndi B-cell Lymphoblastic Leukemia (B LLy) kapena Mixed Phenotype Acute Leukemia (MPAL) akamalandira mankhwala a B-ALL chemotherapy. Odwala alandila ma chemotherapy omwe atsala (kukonza kwakanthawi kochepa ine, kuchedwa kukulitsa, kukonza kwakanthawi II, kukonza), ndi odwala ena atapatsidwa mwayi wopeza inotuzumab. Zolinga zina za kafukufukuyu zikuphatikiza kufufuza ngati kuwachiritsa amuna ndi akazi nthawi yofanana ya chemotherapy kumathandizira zomwe amuna omwe amalandilirako chaka chowonjezera poyerekeza ndi atsikana, komanso kuwunika njira zabwino zothandizira odwala kutsatira pakamwa mankhwala a chemotherapy. Pomaliza, kafukufukuyu adzakhala woyamba kutsatira zotsatira za maphunziro omwe afalitsidwa ndi B-cell Lymphoblastic Leukemia (B LLy) kapena Mixed Phenotype Acute Leukemia (MPAL) akamalandira mankhwala a B-ALL chemotherapy. Odwala alandila ma chemotherapy omwe atsala (kukonza kwakanthawi kochepa ine, kuchedwa kukulitsa, kukonza kwakanthawi II, kukonza), ndi odwala ena atapatsidwa mwayi wopeza inotuzumab. Zolinga zina za kafukufukuyu zikuphatikiza kufufuza ngati kuwachiritsa amuna ndi akazi nthawi yofanana ya chemotherapy kumathandizira zomwe amuna omwe amalandilirako chaka chowonjezera poyerekeza ndi atsikana, komanso kuwunika njira zabwino zothandizira odwala kutsatira pakamwa mankhwala a chemotherapy. Pomaliza, kafukufukuyu adzakhala woyamba kutsatira zotsatira za maphunziro omwe afalitsidwa ndi B-cell Lymphoblastic Leukemia (B LLy) kapena Mixed Phenotype Acute Leukemia (MPAL) akamalandira mankhwala a B-ALL chemotherapy. Zolinga zina za kafukufukuyu zikuphatikiza kufufuza ngati kuwachiritsa amuna ndi akazi nthawi yofanana ya chemotherapy kumathandizira zomwe amuna omwe amalandilirako chaka chowonjezera poyerekeza ndi atsikana, komanso kuwunika njira zabwino zothandizira odwala kutsatira pakamwa mankhwala a chemotherapy. Pomaliza, kafukufukuyu adzakhala woyamba kutsatira zotsatira za maphunziro omwe afalitsidwa ndi B-cell Lymphoblastic Leukemia (B LLy) kapena Mixed Phenotype Acute Leukemia (MPAL) akamalandira mankhwala a B-ALL chemotherapy. Zolinga zina za kafukufukuyu zikuphatikiza kufufuza ngati kuwachiritsa amuna ndi akazi nthawi yofanana ya chemotherapy kumathandizira zomwe amuna omwe amalandilirako chaka chowonjezera poyerekeza ndi atsikana, komanso kuwunika njira zabwino zothandizira odwala kutsatira pakamwa mankhwala a chemotherapy. Pomaliza, kafukufukuyu adzakhala woyamba kutsatira zotsatira za maphunziro omwe afalitsidwa ndi B-cell Lymphoblastic Leukemia (B LLy) kapena Mixed Phenotype Acute Leukemia (MPAL) akamalandira mankhwala a B-ALL chemotherapy.
Malo: Malo 189
Mofulumira kapena Standard BEP Chemotherapy pochiza Odwala omwe ali ndi zotupa zapakatikati kapena zoopsa za Metastatic Germ Cell Tumors.
Kafukufuku woyeserera gawo lachitatu lino amafufuza momwe kuchuluka kwa magazi kwa bleomycin sulphate, etoposide phosphate, ndi cisplatin (BEP) chemotherapy kumagwirira ntchito poyerekeza ndi dongosolo la BEP chemotherapy pochiza odwala omwe ali ndi zotupa zapakati kapena zosavulaza zomwe zafalikira kwa ena malo m'thupi (metastatic). Mankhwala omwe amagwiritsidwa ntchito mu chemotherapy, monga bleomycin sulphate, etoposide phosphate, ndi cisplatin, amagwira ntchito m'njira zosiyanasiyana kuti achepetse kukula kwa maselo otupa, mwina popha ma cell, powalekanitsa kuti asagawike, kapena poletsa kufalikira. Kupatsa chemotherapy ya BEP mwachangu, kapena "kufulumizitsa" kumatha kugwira ntchito bwino ndi zovuta zochepa pochiza odwala omwe ali ndi zotupa zamagulu apakati kapena zoopsa poyerekeza ndi ndandanda yoyenera.
Malo: Malo 139
Thandizani kutsitsimutsa kwama ndemanga