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Chithandizo Chachipatala Pazovuta za Khansa Yapakhungu Yosasamba
Mayesero azachipatala ndi maphunziro ofufuza omwe amakhudza anthu. Mayeso azachipatala pamndandandawu ndi omwe amachiza khansa yapakhungu yopanda khansa ya khansa. Mayesero onse pamndandanda amathandizidwa ndi NCI.
Zambiri za NCI zokhudzana ndi mayesero azachipatala zimafotokozera mitundu ndi magawo am'mayesero ndi momwe amachitikira. Mayesero azachipatala amayang'ana njira zatsopano zotetezera, kuzindikira, kapena kuchiza matenda. Mungafune kuganizira zokhala ndi gawo pakuyesedwa kwachipatala. Lankhulani ndi dokotala wanu kuti akuthandizeni kusankha ngati mukuyenera.
Mayesero 1-25 a 118 1 2 3 4 5 Kenako>
Therapy Target Yotsogozedwa ndi Kuyesedwa Kwachibadwa Pochiza Odwala Omwe Ali Ndi Matenda Olimba Otsitsimutsa, Lymphomas, kapena Multiple Myeloma (The MATCH Screening Trial)
Gawo ili lachiwiri la MATCH limafufuza momwe chithandizo chamankhwala chomwe chimayendetsedwa ndi kuyesa kwa majini chimagwira ntchito kwa odwala omwe ali ndi zotupa zolimba kapena ma lymphomas omwe apita patsogolo motsatira njira imodzi yothandizirana kapena yomwe palibe njira yovomerezeka yothandizira. Mayeso a chibadwa amayang'ana mitundu yapadera ya majini (majini) ya zotupa za odwala. Odwala omwe ali ndi vuto lachibadwa (monga kusintha kwa thupi, kukulitsa, kapena kusunthika) atha kupindula kwambiri ndi chithandizo chamankhwala chomwe chimayambitsa vuto la chibadwa chawo. Kuzindikira zovuta zamtunduwu poyamba kumatha kuthandiza madokotala kukonzekera chithandizo chokwanira kwa odwala omwe ali ndi zotupa zolimba, ma lymphomas, kapena angapo a myeloma.
Malo: malo 1189
Nivolumab pambuyo pa Mgwirizano Wophatikiza Pazithandizo Pochiza Odwala Omwe Ali Ndi Ngozi Yaikulu II-IIIB Cancer
Kafukufukuyu adafufuza momwe nivolumab atagwirira ntchito limodzi pochiza odwala omwe ali pachiwopsezo chachikulu cha khansa yachiwiri ya II-IIIB. Immunotherapy yokhala ndi ma monoclonal antibodies, monga nivolumab, imatha kuthandizira chitetezo chamthupi kulimbana ndi khansa, ndipo imatha kusokoneza kuthekera kwa maselo otupa kukula ndikufalikira.
Malo: malo 745
Pembrolizumab Poyerekeza ndi Kuwonetsetsa Kusamalira Pochiza Odwala Omwe Ali Ndi Gawo Lathunthu la I-III Merkel Cell Cancer.
Gawo ili lachitatu limawunika momwe pembrolizumab imagwirira ntchito poyerekeza ndi momwe angathandizire pochiza odwala omwe ali ndi khansa ya cell I-III Merkel yomwe yachotsedwa kwathunthu ndi opareshoni (resected). Immunotherapy yokhala ndi ma monoclonal antibodies, monga pembrolizumab, imatha kuthandizira chitetezo chamthupi kulimbana ndi khansa, ndipo imatha kusokoneza kuthekera kwa maselo otupa kukula ndikufalikira.
Malo: malo 286
Avelumab wokhala ndi Cetuximab kapena wopanda Pochiza Odwala Omwe Ali ndi Khansa Yapakhungu Yapakhungu Yowopsa
Gawo ili lachiwiri limawunika momwe avelumab omwe alibe kapena cetuximab amagwirira ntchito pochiza odwala omwe ali ndi khansa yapakhungu yama cell yomwe yafalikira m'malo ena m'thupi (patsogolo). Immunotherapy yokhala ndi ma monoclonal antibodies, monga avelumab ndi cetuximab, imatha kuthandizira chitetezo chamthupi kulimbana ndi khansa, ndipo imatha kusokoneza kuthekera kwa maselo otupa kukula ndikufalikira.
Malo: malo 277
Pembrolizumab yokhala kapena yopanda Stereotactic Therapy radiation Therapy pochiza odwala omwe ali ndi khansa yapakatikati kapena ya metastatic Merkel Cell
Kuyeserera kwa gawo lachiwirili komwe kumafufuza momwe pembrolizumab yokhala ndi kapena yopanda stereotactic radiation radiation imagwira ntchito pochiza odwala omwe ali ndi khansa ya cell ya Merkel yomwe yafalikira m'malo ena mthupi. Immunotherapy yokhala ndi ma monoclonal antibodies, monga pembrolizumab, imatha kuthandizira chitetezo chamthupi kulimbana ndi khansa, ndipo imatha kusokoneza kuthekera kwa maselo otupa kukula ndikufalikira. Mankhwala opatsirana pogwiritsa ntchito mphamvu ya stereotactic amagwiritsa ntchito zida zapadera kuti akhazikitse wodwala ndikupereka cheza ku zotupa mwatsatanetsatane. Njirayi imatha kupha maselo otupa ndi kuchepa pang'ono panthawi yayifupi ndikuwononga pang'ono minofu yabwinobwino. Kupereka pembrolizumab ndi stereotactic radiation radiation mankhwala atha kugwira ntchito bwino pochiza odwala omwe ali ndi khansa ya cell ya Merkel.
Malo: 246 malo
Kuchita Mwaluso ndi Chitetezo Phunziro la Tisotumab Vedotin kwa Odwala Omwe Ali Ndi Zotupa Zolimba
Mlanduwu uphunzira tisotumab vedotin kuti muwone ngati ndi mankhwala othandiza a zotupa zolimba komanso zovuta zina (zosafunikira) zomwe zingachitike. Mankhwalawa adzapatsidwa kwa odwala milungu itatu iliyonse.
Malo: malo 12
PD-1 mwa Odwala Omwe Ali Ndi Basal Cell Carcinoma Omwe Adakumana Ndi Kukula Kwa Matenda pa Hedgehog Pathway Inhibitor Therapy, kapena Anali Osavomerezeka ndi Hedgehog Pathway Inhibitor Therapy Asanachitike.
Cholinga chachikulu ndikuyerekeza kuchuluka kwa mayankho (ORR) a metastatic Basal Cell Carcinoma (BCC) (gulu 1) komanso kwa BCC (gulu 2) losasunthika komwe likugwiritsidwa ntchito ndi REGN2810 ngati monotherapy
Malo: malo 15
Gawo Lachiwiri Lophunzira la Tipifarnib mu Mutu Wosakanikirana ndi Khansa Yam'mitsempha Ndi Kusintha kwa HRAS
Gawo lachiwiri lakafukufuku wofufuza zomwe zimachitika poyankha (ORR) ya tipifarnib m'maphunziro omwe ali ndi zotupa zapamwamba zomwe zimanyamula masinthidwe a HRAS komanso omwe alibe mankhwala ochiritsira omwe alipo. Zindikirani; Cohort 2 yokha (Head & Neck SCC) ndi cohort 3 (Other SCC) ndiyotseguka pano
Malo: Malo 11
Kafukufuku Wofufuza za Immuno-Therapy Kafukufuku Wofufuza Chitetezo ndi Kuchita Bwino kwa Nivolumab, ndi Nivolumab Combination Therapy mu Zotupa zogwirizana ndi Virus
Cholinga cha kafukufukuyu kuti afufuze chitetezo cha nivolumab, ndi nivolumab kuphatikiza mankhwala, kuti athandize odwala omwe ali ndi zotupa zokhudzana ndi ma virus. Ma virus ena amadziwika kuti amatenga gawo pakapangidwe kazotupa ndikukula. Kafukufukuyu adzafufuza zotsatira zamankhwalawa, kwa odwala omwe ali ndi zotupa zotsatirazi: - Khansa ya canal ya Canal-Osalembetsanso chotupachi - Khansa ya pachibelekero - Epstein Barr Virus (EBV) khansa ya m'mimba yabwino-Osatinso izi Mtundu wa chotupa - Khansa ya Merkel - Khansa ya Penile-Kulembetsanso mtundu uwu wa khansa - Khansa ya m'mimba ndi ya vulvar-Simulembetsanso chotupachi - Khansa ya Nasopharyngeal - Simulembetsanso chotupachi - Khansa ya Mutu ndi Khosi - Simulembetsanso chotupachi
Malo: malo 10
Pembrolizumab motsutsana ndi Placebo Kutsatira Opaleshoni ndi Magetsi mwa Ophunzira Ndi Omwe Ali Ndi Advanced Cutaneous Squamous Cell Carcinoma (MK-3475-630 / KEYNOTE-630)
Ichi ndi kafukufuku wosasintha, wakhungu kawiri yemwe amafanizira pembrolizumab ndi placebo yoperekedwa ngati othandizira othandizira omwe ali pachiwopsezo chotsogola chotchedwa squamous cell carcinoma (LA cSCC) omwe achita opareshoni ndicholinga chothandizira kuphatikizira ndi radiotherapy. Lingaliro lofunikira ndikuti pembrolizumab ndiyabwino kuposa placebo pakuchulukitsa kupulumuka kwaulere (RFS).
Malo: malo 10
Kafukufukuyu Akuwunika KRT-232, Novel Oral Small Molecule Inhibitor ya MDM2, yothandizira odwala omwe ali nawo (p53WT) Merkel Cell Carcinoma Omwe Ataya Anti-PD-1 / PD-L1 Immunotherapy
Kafukufukuyu akuwunika KRT-232, buku laling'onoting'ono laling'ono la molekyulu yoletsa MDM2, yothandizira odwala omwe ali ndi Merkel Cell Carcinoma (MCC) omwe alephera kulandira chithandizo ndi anti-PD-1 imodzi kapena anti-PD-L1 immunotherapy. Kuletsa kwa MDM2 ndi njira yatsopano yochitira mu MCC. Kafukufukuyu ndi Phase 2, Open-Label, Single-Arm Study ya KRT-232 mwa Odwala omwe ali ndi p53 Wild-Type (p53WT) Merkel Cell Carcinoma
Malo: Malo 11
Kafukufuku wa XmAb®23104 mu Ophunzira Omwe Ali Ndi Zotupa Zapamwamba Zolimba (DUET-3)
Awa ndi Phase 1, kuchuluka kwa kuchuluka, kukwera kwa kuchuluka kwa kuchuluka kwa kuchuluka kwa MTD / RD ndi mtundu wa XmAb23104, kufotokoza chitetezo ndi kulolerana, kuyesa PK ndi immunogenicity, ndikuwunikiranso ntchito zotsutsana ndi zotupa za XmAb23104 m'mitu yomwe yasankhidwa zotupa zolimba zotsogola.
Malo: Malo 9
Adjuvant Avelumab ku Merkel Cell Cancer
Kafukufukuyu adafufuza momwe avelumab imagwirira ntchito pochiza odwala khansa ya Merkel yomwe yafalikira ku ma lymph node ndikuchitidwa opaleshoni popanda kapena radiation. Ma antibodies a monoclonal, monga avelumab, amatha kulimbikitsa chitetezo cha mthupi komanso kusokoneza kuthekera kwa maselo otupa kukula ndikufalikira.
Malo: malo 10
QUILT-3.055: Kafukufuku wa ALT-803 Ophatikizana Ndi PD-1 / PD-L1 Checkpoint Inhibitor mwa Odwala Omwe Ali ndi Khansa Yapamwamba
Ili ndi gawo lachiwiri la IIb, dzanja limodzi, multicohort, lotseguka lotsegulira ma ALT-803 limodzi ndi PD-1 / PD-L1 checkpoint inhibitor yovomerezedwa ndi FDA mwa odwala khansa omwe apita patsogolo kutsatira poyankha koyamba ku chithandizo ndi PD-1 / PD-L1 checkpoint inhibitor therapy. Odwala onse adzalandira chithandizo chophatikizira cha PD-1 / PD-L1 checkpoint inhibitor kuphatikiza ALT-803 mpaka 16. Kuzungulira kulikonse kumakhala milungu isanu ndi umodzi. Odwala onse adzalandira ALT-803 kamodzi pamasabata atatu. Odwala alandiranso cholembera cholembera chomwe adalandira panthawi yomwe adalandira chithandizo cham'mbuyomu. Kuwunika kwa ma Radiologic kumachitika kumapeto kwa nthawi iliyonse yamankhwala. Chithandizo chidzapitilira kwa zaka ziwiri, kapena mpaka wodwalayo atatsimikizira kuti matenda akupita patsogolo kapena kawopsedwe kosavomerezeka, atasiya kuvomereza, kapena ngati Wofufuzayo akuwona kuti sizofunikiranso wodwalayo kupitiliza kulandira chithandizo. Odwala adzatsatiridwa chifukwa cha kupita patsogolo kwa matenda, chithandizo chamankhwala cham'mbuyomu, komanso kupulumuka miyezi 24 yapitayi poyendetsa mankhwala oyamba.
Malo: Malo 9
Chitetezo, Kulekerera, Kutulutsa thupi, komanso Antitumor Ntchito ya GEN-009 Adjuvanted Vaccine
Pakafukufukuyu, a Genocea akuwunika katemera wofufuzira, wokometsera payekha, GEN-009, yemwe akupangidwa kuti azithandizira odwala omwe ali ndi zotupa zolimba. Chida chogulitsa ndi Genocea, chotchedwa ATLAS ™ (Antigen Lead Acquisition System) chidzagwiritsidwa ntchito pozindikiritsa neoantigen mu chotupa cha wodwala aliyense chomwe chimadziwika ndi ma CD4 ndi / kapena ma CD8 T ake. Ma neoantigen omwe amadziwika ndi ATLAS adzaphatikizidwa mu katemera wothandizirana ndi wodwala ngati ma peptide ataliatali (SLPs).
Malo: Malo 9
Kafukufuku wa NKTR-262 Mgwirizano Ndi NKTR-214 komanso NKTR-214 Plus Nivolumab mwa Odwala Omwe Ali Ndi Matenda Otukuka Kapena Amatenda Olimba Kwambiri.
Odwala alandila intra-tumoral (IT) NKTR-262 m'masabata atatu azachipatala. Pakati pa gawo loyesa gawo la gawo 1, NKTR-262 iphatikizidwa ndi kayendedwe kabwino ka bempegaldesleukin. Pambuyo pakudziwitsa za Phase 2 mlingo (RP2D) wa NKTR-262, pakati pa 6 ndi 12 odwala atha kulembetsa ku RP2D kuti apitilize kudziwika ndi chitetezo ndi kulolerana kwa kuphatikiza kwa NKTR 262 kuphatikiza bempegaldesleukin (doublet) kapena NKTR 262 kuphatikiza bempegaldesleukin kuphatikiza nivolumab (triplet) mu Cohorts A ndi B, motsatana. Mu gawo lokulitsa la gawo la 2, odwala adzathandizidwa ndi maphatidwe awiri kapena atatu mumayendedwe obwereranso / obwezeretsa komanso njira zamankhwala zoyambilira.
Malo: malo 14
Kuyesedwa Kwadongosolo kwa Pembrolizumab & Radiotherapy Poyerekeza ndi Radiotherapy mu High-Risk Soft Tissue Sarcoma of the Extremity
Ili ndi lotseguka, lotseguka, lotsegulira magawo angapo poyerekeza neoadjuvant radiotherapy yotsatiridwa ndi resection ya neoadjuvant pembrolizumab yokhala ndi radiotherapy yofananira, yotsatiridwa ndi resection ya opaleshoni ndi adjuvant pembrolizumab. Nthawi yonse ya pembrolizumab idzakhala chaka chimodzi m'manja oyesera.
Malo: malo 10
Proton Beam kapena Photon-based Intensity-Modulated Radiation Therapy pochiza Odwala omwe ali ndi khansa ya Salivary Gland, Cancer Cancer, kapena Melanoma
Kuyeserera kwachiwiri kwa gawo lachiwirili kumafufuza zoyipa za proton beam kapena photon-based intension-modulated radiation therapy pochiza odwala khansa ya m'matumbo, khansa yapakhungu, kapena khansa ya pakhungu. Mankhwala othandizira ma radiation a Proton amagwiritsa ntchito tinthu tating'onoting'ono tating'onoting'ono kuti titsegulire cheza pachotupa ndipo sichimatha kuwononga minofu yabwinobwino. Mankhwala opatsirana pogwiritsa ntchito mphamvu yolimbitsa thupi amagwiritsa ntchito ma X-ray opangira mphamvu kwambiri kuti athetse chotupacho ndipo amathanso kuwononga minofu yabwinobwino. Sizikudziwika ngati mankhwala a proton beam radiation ndi othandiza kwambiri kuposa mankhwala opangira mphamvu ya radiation pochiza odwala khansa ya m'matumbo, khansa yapakhungu, kapena khansa ya pakhungu.
Malo: Malo 8
Khungu lapakompyuta la Brachytherapy Pochizira Odwala Achikulire Omwe Akupezeka Ndi Gawo Loyambira Loyambira kapena Khansa Yapakhungu Ya khungu la squamous
Woyeserera woyesererayo akuwunika momwe khungu lamagetsi la brachytherapy (ESSB) limagwirira ntchito pochiza odwala okalamba omwe ali ndi khansa yapakhungu yaposachedwa kapena khansa ya khungu la squamous. ESSB ndi mtundu wa mankhwala a radiation omwe amagwiritsa ntchito ogwiritsa ntchito pakhungu kuyika magwero amagetsi azamagetsi kuti athetse khansa yapakhungu. Ogwiritsa ntchito khungu ndi ozungulira, ma diski osalala omwe amaphatikizidwa ndi makina othandizira poizoniyu, ndipo amapereka ma radiation kuti akalandire chithandizo. ESSB itha kuloleza kuti chotupacho chithandizidwe pomwe matupi athanzi sakuvulazidwa ndi radiation.
Malo: Malo 8
Chithandizo Cha radiation Stereotactic Pochiza Odwala omwe ali ndi Cancer ya Metastatic yokhala ndi Kuchepetsa Kwambiri pa Immune Checkpoint Inhibitors
Gawo ili lachiwiri limawunika momwe ma radiation opatsirana pogwiritsa ntchito ma stereotactic amagwirira ntchito pochiza odwala khansa yomwe yafalikira m'malo ena mthupi mosasunthika pang'ono mukamayang'aniridwa ndi chitetezo cha mthupi. Mankhwala opatsirana pogwiritsa ntchito mphamvu ya stereotactic amagwiritsa ntchito zida zapadera kuti akhazikitse wodwala ndikupereka cheza ku zotupa mwatsatanetsatane. Njirayi imatha kupha maselo otupa ndi kuchepa pang'ono panthawi yayifupi ndikuwononga pang'ono minofu yabwinobwino.
Malo: Malo 7
Cabozantinib S-malate ndi Cetuximab pochiza odwala omwe ali ndi khansa ya Metastatic Head ndi Neck Squamous Cell Cancer.
Gawo ili loyeserera limafufuza zoyipa ndi kuchuluka kwa cabozantinib S-malate ndipo akapatsidwa limodzi ndi cetuximab pochiza odwala khansa yam'mutu ndi khosi ya squamous cell yomwe yafalikira m'malo ena mthupi. Cabozantinib S-malate imatha kuchepetsa kukula kwa maselo a khansa podula magazi omwe khansa imafunikira kuti ipitirire ndikukula. Immunotherapy yokhala ndi ma monoclonal antibodies, monga cetuximab, imatha kuyambitsa kusintha kwa chitetezo chamthupi ndipo imatha kusokoneza kuthekera kwa maselo otupa kukula ndikufalikira. Kupereka cabozantinib S-malate ndi cetuximab zitha kugwira bwino ntchito pochiza odwala khansa yamutu ndi khosi.
Malo: Malo 7
Chitetezo, Kugwira Ntchito Koyambirira ndi PK ya Isatuximab (SAR650984) Yokha kapena Pamodzi Ndi Atezolizumab mwa Odwala Omwe Ali Ndi Matenda Oipa Kwambiri
Zolinga Zoyambirira: - Phase1: Kuzindikiritsa chitetezo ndi kulolerana kwa isatuximab kuphatikiza ndi atezolizumab mwa omwe ali ndi hepatocellular carcinoma (HCC), platin-refractory recurrent / metastatic squamous cell carcinoma ya mutu ndi khosi (SCCHN), platinum-resistant / khansa ya ovarian epithelial ovarian (EOC), kapena glioblastoma multiforme (GBM), ndikuzindikira mlingo woyenera wa Phase 2 (RP2D). - Phase2: Kuyesa kuchuluka kwa mayankho (RR) a isatuximab kuphatikiza atezolizumab mwa omwe akutenga nawo mbali HCC kapena SCCHN kapena EOC. - Phase2: Kuyesa kuchuluka kwa kupulumuka kwaulere kwa miyezi 6 (PFS-6) ya isatuximab kuphatikiza atezolizumab, kapena ngati wothandizira m'modzi mwa omwe ali ndi GBM. Zolinga Zachiwiri: - Kuunika chitetezo cha isatuximab monotherapy (GBM kokha), kapena kuphatikiza ndi atezolizumab mu Phase 2. - Kuunika kuchuluka kwa mphamvu ya isatuximab ndi atezolizumab. - Kudziwitsa mbiri ya pharmacokinetic (PK) ya isatuximab single agent (GBM kokha) ndi atezolizumab kuphatikiza ndi isatuximab. - Kuwunika momwe isatuximab imagwirira ntchito limodzi ndi atezolizumab, kapena wothandizira m'modzi (GBM kokha).
Malo: Malo 7
Kafukufuku wa INCMGA00012 mu Metastatic Merkel Cell Carcinoma (POD1UM-201)
Cholinga cha phunziroli ndikuwunika zochitika zamatenda ndi chitetezo cha INCMGA00012 mwa omwe ali nawo omwe ali ndi kachilombo ka Merkel cell carcinoma (MCC).
Malo: Malo 8
Lenvatinib Mesylate ndi Cetuximab pochiza Odwala omwe ali ndi Recurrent kapena Metastatic Head ndi Neck Squamous Cell Carcinoma kapena Cutaneous Squamous Cell Carcinoma
Gawo ili lakuyesa kwa I / Ib limafufuza za mlingo woyenera komanso zoyipa za lenvatinib mesylate ndi cetuximab pochiza odwala omwe ali ndi mutu ndi khosi squamous cell carcinoma kapena cutaneous squamous cell carcinoma yomwe yabwerera (yabwereza) kapena kufalikira m'malo ena mthupi (metastatic ). Lenvatinib mesylate ikhoza kuyimitsa kukula kwa zotupa potseka ma enzyme ena ofunikira kuti maselo akule. Ma antibodies a monoclonal, monga cetuximab, atha kusokoneza kuthekera kwa maselo otupa kukula ndikufalikira. Kupatsa lenvatinib mesylate ndi cetuximab zitha kugwira bwino ntchito pochiza odwala omwe ali ndi mutu ndi khosi squamous cell carcinoma kapena cutaneous squamous cell carcinoma.
Malo: Malo 7
PEN-221 ku Somatostatin Receptor 2 Kufotokozera Khansa Yapamwamba Kuphatikiza Neuroendocrine ndi Protocol ya Cancer Lung Cancer PEN-221-001 ndiwotseguka, wowerengeka wa Phase 1 / 2a wowunika PEN-221 mwa odwala omwe ali ndi SSTR2 akuwonetsa gastroenteropancreatic (GEP) kapena mapapo kapena thymus kapena zotupa zina za neuroendocrine kapena khansa yaying'ono yamapapo yam'mapapo kapena cell cell neuroendocrine carcinoma yam'mapapo.
Malo: Malo 7
1 2 3 4 5 Kenako> National Cancer Institute
