Za-khansa / chithandizo / mayesero azachipatala / matenda / kaposi-sarcoma / chithandizo

Chithandizo Chachipatala cha Kaposi Sarcoma

Mayesero azachipatala ndi maphunziro ofufuza omwe amakhudza anthu. Mayesero azachipatala pamndandandawu ndi a mankhwala a Kaposi sarcoma. Mayesero onse pamndandanda amathandizidwa ndi NCI.

Zambiri za NCI zokhudzana ndi mayesero azachipatala zimafotokozera mitundu ndi magawo am'mayesero ndi momwe amachitikira. Mayesero azachipatala amayang'ana njira zatsopano zotetezera, kuzindikira, kapena kuchiza matenda. Mungafune kuganizira zokhala ndi gawo pakuyesedwa kwachipatala. Lankhulani ndi dokotala wanu kuti akuthandizeni kusankha ngati mukuyenera.

Mayesero 1-7 pa 7

Nivolumab ndi Ipilimumab pochiza Odwala omwe ali ndi kachilombo ka HIV kamene kamabwereranso kapena kachilombo koyambitsa matenda a Hodgkin Lymphoma kapena zotupa zolimba zomwe zimatha kapena kuchotsedwa ndi opaleshoni

Gawo ili loyeserera limafufuza zoyipa ndi mankhwala abwino kwambiri a nivolumab akamaperekedwa ndi ipilimumab pochiza odwala omwe ali ndi kachilombo ka HIV (HODgkin lymphoma) yomwe yabwerera pambuyo poti yasintha kapena siyiyankha chithandizo, kapena zotupa zolimba zomwe zafalikira m'malo ena m'thupi kapena sizingachotsedwe ndi opaleshoni. Immunotherapy yokhala ndi ma monoclonal antibodies, monga ipilimumab ndi nivolumab, imatha kuthandizira chitetezo chamthupi kulimbana ndi khansa, ndipo imatha kusokoneza kuthekera kwa maselo otupa kukula ndikufalikira. Ipilimumab ndi mankhwala omwe amatsutsana ndi molekyulu yotchedwa cytotoxic T-lymphocyte antigen 4 (CTLA-4). CTLA-4 imayang'anira gawo lina la chitetezo chamthupi mwanu potseka. Nivolumab ndi mtundu wa antibody womwe umafotokoza za kufa kwa cell 1 (PD-1), puloteni yomwe imayambitsa kuwonongeka kwa maselo amthupi. Kupatsa ipilimumab ndi nivolumab kumatha kugwira ntchito bwino pochiza odwala omwe ali ndi kachilombo ka HIV komwe kumalumikizidwa ndi Hodgkin lymphoma kapena zotupa zolimba poyerekeza ndi ipilimumab yokhala ndi nivolumab yokha.

Malo: malo 28

Nelfinavir Mesylate pochiza Odwala omwe ali ndi Kaposi Sarcoma

Kuyesa koyeserera kumeneku kwa kafukufukuyu kumafufuza momwe nelfinavir mesylate imagwirira ntchito pochiza odwala omwe ali ndi Kaposi sarcoma. Nelfinavir mesylate ikhoza kuyimitsa kukula kwa zotupa mwa kulepheretsa michere ina yofunikira pakukula kwamaselo.

Malo: Malo 11

sEphB4-HSA pochiza Odwala omwe ali ndi Kaposi Sarcoma

Gawo ili lachiwiri lachiyeso limafufuza zophatikizika za EphB4-HSA fusion protein (sEphB4-HSA) pochiza odwala omwe ali ndi Kaposi sarcoma. Mapuloteni osakanikirana a EphB4-HSA amatha kulepheretsa kukula kwa mitsempha yamagazi yomwe imapereka magazi ku khansa, komanso kutetezeranso maselo a khansa kukula.

Malo: malo 10

Pembrolizumab pochiza odwala omwe ali ndi kachilombo ka HIV ndikubwezeretsanso, kutulutsa, kapena kufalitsa ziwalo zoyipa.

Gawo ili loyesa limafufuza zoyipa za pembrolizumab pochiza odwala omwe ali ndi kachilombo ka HIV (HIV) ndi zotupa zoyipa zomwe zabwerera (zabwereranso), osayankha chithandizo (chotsutsa), kapena agawira dera lalikulu m'thupi (kufalitsa). Ma antibodies a monoclonal, monga pembrolizumab, amatha kulepheretsa chotupa kapena khansa kukula m'njira zosiyanasiyana potengera maselo ena. Zitha kuthandizanso chitetezo cha mthupi kupha ma cell a khansa.

Malo: malo 10

Intra-lesional Nivolumab pochiza Odwala omwe ali ndi Cutaneous Kaposi Sarcoma

Gawo ili loyeserera limafufuza zoyipa za nivolumab jekeseni mwachindunji pachilonda ndikuwona momwe imagwirira ntchito pochiza odwala omwe ali ndi Kaposi sarcoma. Immunotherapy yokhala ndi ma monoclonal antibodies, monga nivolumab, imatha kuthandizira chitetezo chamthupi kulimbana ndi khansa, ndipo imatha kusokoneza kuthekera kwa maselo otupa kukula ndikufalikira.

Malo: malo awiri

Mbiri ya KSHV yotupa Cytokine Syndrome (KICS)

Chiyambi: - KSHV yotupa cytokine syndrome (KICS) ndi matenda omwe angodziwika kumene chifukwa cha Kaposi sarcoma-herpesvirus (KSHV). Vutoli limatha kuyambitsa khansa. Anthu omwe ali ndi KICS amatha kukhala ndi zizindikilo zoopsa. Amaphatikizapo kutentha thupi, kuchepa thupi, ndi madzi m'miyendo kapena pamimba. Anthu omwe ali ndi KICS atha kukhala pachiwopsezo chotenga khansa ina yokhudzana ndi KSHV. Khansa izi zimaphatikizapo Kaposi sarcoma ndi lymphoma. Chifukwa KICS ndi matenda omwe angotuluka kumene, pamafunika kudziwa zambiri za momwe matendawa amagwirira ntchito komanso zomwe angachite kuti awachiritse. Zolinga: - Kutenga zidziwitso zamankhwala ndi zamankhwala kuchokera kwa anthu omwe ali ndi KSHV yotupa cytokine syndrome. Kuvomerezeka: - Anthu azaka zosachepera 18 omwe ali ndi kachilombo ka Kaposi sarcoma herpes ndi zizindikilo zomwe zimafanana ndi zomwe zimayambitsa KICS. Kupanga: - Ophunzira azakhala ndi maulendo owerenga pafupipafupi. Ndondomekoyi idzatsimikiziridwa ndi ochita kafukufukuyu. - Ophunzira adzapereka mbiri yakale yazachipatala ndikuwunika kwathunthu. Zitsanzo zamagazi ndi mkodzo zisonkhananso. - Anthu omwe ali ndi KICS omwe amafunikira chithandizo atha kulandira chithandizo chatsopano. Mankhwalawa atha kuphatikiza mankhwala ochepetsa ma virus komanso mankhwala a chemotherapy, kutengera mtundu wa matendawa. - Ophunzirawo adzakhala ndi maphunziro azithunzi, monga chifuwa x-ray ndi ma scan scography, kuti aphunzire zotupazo. - Mafupa a mafupa ndi ma lymph node biopsies atha kuchitidwa kuti atolere mitundu yazinyama kuti aphunzire. - Ophunzira omwe ali ndi Kaposi sarcoma adzakhala ndi zithunzi zojambulidwa. - Anthu omwe ali ndi KICS omwe amafunikira chithandizo atha kulandira chithandizo chatsopano. Mankhwalawa atha kuphatikiza mankhwala ochepetsa ma virus komanso mankhwala a chemotherapy, kutengera mtundu wa matendawa. - Ophunzirawo adzakhala ndi maphunziro azithunzi, monga chifuwa x-ray ndi ma scan scography, kuti aphunzire zotupazo. - Mafupa a mafupa ndi ma lymph node biopsies atha kuchitidwa kuti atolere mitundu yazinyama kuti aphunzire. - Ophunzira omwe ali ndi Kaposi sarcoma adzakhala ndi zithunzi zojambulidwa. - Anthu omwe ali ndi KICS omwe amafunikira chithandizo atha kulandira chithandizo chatsopano. Mankhwalawa atha kuphatikiza mankhwala ochepetsa ma virus komanso mankhwala a chemotherapy, kutengera mtundu wa matendawa. - Ophunzirawo adzakhala ndi maphunziro azithunzi, monga chifuwa x-ray ndi ma scan scography, kuti aphunzire zotupazo. - Mafupa a mafupa ndi ma lymph node biopsies atha kuchitidwa kuti atolere mitundu yazinyama kuti aphunzire. - Ophunzira omwe ali ndi Kaposi sarcoma adzakhala ndi zithunzi zojambulidwa. - Mafupa a mafupa ndi ma lymph node biopsies atha kuchitidwa kuti atolere mitundu yazinyama kuti aphunzire. - Ophunzira omwe ali ndi Kaposi sarcoma adzakhala ndi zithunzi zojambulidwa. - Mafupa a mafupa ndi ma lymph node biopsies atha kuchitidwa kuti atolere mitundu yazinyama kuti aphunzire. - Ophunzira omwe ali ndi Kaposi sarcoma adzakhala ndi zithunzi zojambulidwa.

Malo: malo awiri

Pomalidomide Pamodzi ndi Liposomal Doxorubicin mwa Anthu Omwe Ali Ndi Kutukuka Kwambiri kapena Kotsutsa Kaposi Sarcoma

Chiyambi: Kaposi sarcoma (KS) ndi khansa yomwe imawonekera kwambiri kwa anthu omwe ali ndi kachilombo ka HIV. Zimayambitsa zilonda. Izi nthawi zambiri zimakhala pakhungu koma nthawi zina zimakhala m'mimba, m'mapapu, komanso m'mimba. Ochita kafukufuku amaganiza kuti kuphatikiza kwa mankhwala kumatha kuthandizira KS. Cholinga: Kuyesa kuphatikiza mankhwala a khansa pomalidomide (CC-4047) ndi liposomal doxorubicin (Doxil) mwa anthu omwe ali ndi KS. Kuvomerezeka: Anthu azaka 18 ndi kupitilira ndi KS Design: Ophunzira atenga nawo mbali ndi: Mbiri ya zamankhwala Mafunso Kuyesa kwakuthupi Magazi, mkodzo, ndi kuyesa kwa mtima Chifuwa X-ray Biopsy: Zitsanzo zazing'ono zazing'ono zimachotsedwa pachilonda cha KS. Kuyeza kwa CT komwe kungachitike Kuyesedwa kwamapapu kapena kwamatumbo ndi endoscope: Chida chosinthasintha chimayang'ana mkati mwa chiwalo. Ophunzira atenga mankhwalawa mozungulira masabata a 4. Adzatenga Doxil kudzera pa IV pa Tsiku 1 pakuzungulira kulikonse. Adzatenga mapiritsi a CC-4047 pakamwa tsiku lililonse kwa masabata atatu oyambilira. Ophunzira azichezeredwa kambiri: Asanayambe kulandira chithandizo Kuyambitsa mkombero Tsiku 15 la magawo awiri oyendera Ulendo umaphatikizapo kubwereza kwa kuyezetsa komanso: Magazi angapo amakoka Zithunzi za zotupa Ophunzira azisunga zolemba zawo. Ophunzira atenga aspirin kapena mankhwala ena kuti ateteze magazi. Ophunzira omwe ali ndi kachilombo ka HIV adzalandira mankhwala opatsirana pogonana. Ophunzira ena adzayesedwa PET. Ophunzira adzapitiliza kulandira chithandizo bola ngati angavomereze ndipo KS yawo ikuyenda bwino. Akalandira chithandizo, azikhala ndi maulendo obwereza kwazaka zisanu ... Musanayambe kumwa mankhwala Kuyamba kuzungulira tsiku 15 la magawo awiri oyambilira Maulendo amaphatikizaponso kubwereza kuyezetsa komanso: Magazi angapo amakoka Zithunzi za zotupa Ophunzira azisunga zolemba zawo. Ophunzira atenga aspirin kapena mankhwala ena kuti ateteze magazi. Ophunzira omwe ali ndi kachilombo ka HIV adzalandira mankhwala opatsirana pogonana. Ophunzira ena adzayesedwa PET. Ophunzira adzapitiliza kulandira chithandizo bola ngati angavomereze ndipo KS yawo ikuyenda bwino. Akalandira chithandizo, azikhala ndi maulendo obwereza kwazaka zisanu ... Musanayambe kumwa mankhwala Kuyamba kuzungulira tsiku 15 la magawo awiri oyambilira Maulendo amaphatikizaponso kubwereza kuyezetsa komanso: Magazi angapo amakoka Zithunzi za zotupa Ophunzira azisunga zolemba zawo. Ophunzira atenga aspirin kapena mankhwala ena kuti ateteze magazi. Ophunzira omwe ali ndi kachilombo ka HIV adzalandira mankhwala opatsirana pogonana. Ophunzira ena adzayesedwa PET. Ophunzira adzapitiliza kulandira chithandizo bola ngati angavomereze ndipo KS yawo ikuyenda bwino. Akalandira chithandizo, azikhala ndi maulendo obwereza kwazaka zisanu ... Ophunzira omwe ali ndi kachilombo ka HIV adzalandira mankhwala opatsirana pogonana. Ophunzira ena adzayesedwa PET. Ophunzira adzapitiliza kulandira chithandizo bola ngati angavomereze ndipo KS yawo ikuyenda bwino. Akalandira chithandizo, azikhala ndi maulendo obwereza kwazaka zisanu ... Ophunzira omwe ali ndi kachilombo ka HIV adzalandira mankhwala opatsirana pogonana. Ophunzira ena adzayesedwa PET. Ophunzira apitiliza kulandira chithandizo bola ngati angavomereze ndipo KS yawo ikuyenda bwino. Akalandira chithandizo, azikhala ndi maulendo obwereza kwazaka zisanu ...

Kumalo: National Institutes of Health Clinical Center, Bethesda, Maryland