Pafupifupi-khansa / chithandizo / mayesero azachipatala / matenda / intraocular-melanoma / chithandizo

Chithandizo Chachipatala Mayeso a Intraocular Melanoma

Mayesero azachipatala ndi maphunziro ofufuza omwe amakhudza anthu. Mayeso azachipatala pamndandandawu ndi amtundu wa intraocular melanoma. Mayesero onse pamndandanda amathandizidwa ndi NCI.

Zambiri za NCI zokhudzana ndi mayesero azachipatala zimafotokozera mitundu ndi magawo am'mayesero ndi momwe amachitikira. Mayesero azachipatala amayang'ana njira zatsopano zotetezera, kuzindikira, kapena kuchiza matenda. Mungafune kuganizira zokhala ndi gawo pakuyesedwa kwachipatala. Lankhulani ndi dokotala wanu kuti akuthandizeni kusankha ngati mukuyenera.

Mayesero 1-25 mwa 25

Chitetezo ndi Kuchita Bwino kwa IMCgp100 Poyerekeza ndi Kafukufuku Wosankha mu Advanced Uveal Melanoma

Kuwunika kupulumuka kwa odwala achikulire a HLA-A * 0201 omwe ali ndi UM omwe sanalandire chithandizo akulandila IMCgp100 poyerekeza ndi Investigator's Choice ya dacarbazine, ipilimumab, kapena pembrolizumab.

Malo: malo 19

Phunziro la XmAb®22841 Monotherapy & in Combination w / Pembrolizumab in Subjects w / Selected Advanced Solors Tumors

Awa ndi Phase 1, mlingo wambiri, kuchuluka kwakukwera kwamaphunziro ndi kuchuluka kwa mapangidwe okonzedwa kuti afotokozere kuchuluka kwakulekerera ndi / kapena mlingo woyenera wa XmAb22841 monotherapy komanso kuphatikiza ndi pembrolizumab; kuwunika chitetezo, kulolerana, pharmacokinetics, immunogenicity, ndi anti-chotupa ntchito ya XmAb22841 monotherapy komanso kuphatikiza ndi pembrolizumab m'mitu yomwe ili ndi zotupa zolimba zotsogola.

Malo: malo 10

Kafukufuku wa RP1 Monotherapy ndi RP1 Mgwirizano Ndi Nivolumab

RPL-001-16 ndi Phase 1/2, lotseguka chizindikiro, kuchuluka kwa kuchuluka ndi kufalikira kwachipatala cha RP1 chokha komanso kuphatikiza nivolumab m'maphunziro akulu omwe ali ndi zotupa zolimba komanso / kapena zotsutsa, kuti adziwe kuchuluka kwakulekerera (MTD) ndi mlingo woyenera wa Phase 2 (RP2D), komanso kuwunika momwe ntchito ikuyendera.

Malo: 6 malo

Phunzirani Mu Mitu Yokhala Ndi Melanoma Yaing'ono Yaikulu Ya Choroidal

Cholinga chachikulu ndikuwunika chitetezo, kusadwala kwamthupi ndi magwiridwe antchito amodzi mwamankhwala atatu ndikubwereza mayendedwe amtundu wa Light-activated AU-011 ndi pulogalamu imodzi kapena ziwiri za laser zochizira anthu omwe ali ndi choroidal melanoma.

Malo: 4 malo

Kafukufuku wa IDE196 mwa Odwala Omwe Ali Ndi Zotupa Zolimba Zosunga GNAQ / 11 Masinthidwe kapena PRKC Fusions

Izi ndi gawo la 1/2, malo apakati, owerengera otseguka omwe adapangidwa kuti athe kuwunika chitetezo ndi anti-chotupa cha IDE196 mwa odwala omwe ali ndi zotupa zolimba zomwe zimakhala ndi kusintha kwa GNAQ kapena GNA11 (GNAQ / 11) kapena kusokonekera kwa PRKC, kuphatikiza metastatic uveal melanoma (MUM), khansa yapakhanda yocheperako, khansa yoyipa, ndi zotupa zina zolimba. Gawo 1 (kuchuluka kwa mlingo) liziwunika chitetezo, kulolerana ndi mankhwala osokoneza bongo a IDE196 kudzera muyezo wokwera kwa mlingo ndikuzindikira mlingo woyenera wa Phase 2. Ntchito zachitetezo ndi anti-chotupa zidzayesedwa mu gawo la 2 (kukulitsa kwa mlingo) mu kafukufukuyu.

Malo: 4 malo

Selumetinib Sulfate Pochiza Odwala Omwe Ali Ndi Melanoma Yovundula kapena GNAQ / GNA11 Melanoma Yosinthidwa Yomwe Ndi Metastatic kapena Sitha Kuchotsedwa ndi Opaleshoni

Gawoli Ib limafufuza zoyipa komanso mankhwala abwino kwambiri a selumetinib sulphate pochiza odwala omwe ali ndi melanoma kapena GNAQ / GNA11 yomwe yasintha khansa ya khansa yomwe yafalikira kuchokera kumalo oyambira kupita kumalo ena m'thupi kapena sangathe kuchotsedwa ndi opaleshoni. Selumetinib sulphate ikhoza kuyimitsa kukula kwa zotupa mwa kulepheretsa michere ina yofunikira pakukula kwamaselo.

Malo: malo atatu

Virus Yosinthidwa VSV-IFNbetaTYRP1 pochiza Odwala omwe ali ndi khansa ya Stage III-IV

Gawo ili ndikuyesedwa kumayesa zovuta ndi kuchuluka kwa kachilombo kosinthidwa kotchedwa VSV-IFNbetaTYRP1 pochiza odwala omwe ali ndi khansa yapakhungu ya III-IV. Vuto la vesicular stomatitis (VSV) lasinthidwa kuti liphatikize majini ena owonjezera: mtundu wa interferon beta (hIFNbeta), womwe ungateteze maselo abwinobwino kuti asatenge kachilomboka, ndi TYRP1, yomwe imafotokozedwa makamaka m'matope a khungu. imapanga khungu loteteza khungu lotsekemera) ndipo ma cell a zotupa a khansa ya khansa, ndipo imatha kuyambitsa chitetezo champhamvu chamthupi kupha maselo otupa a khansa ya khansa.

Malo: malo awiri

Kafukufuku wa PLX2853 mu Advanced Malignancies.

Cholinga cha kafukufukuyu ndikuwunika za chitetezo, pharmacokinetics, pharmacodynamics ndikuwunika koyambirira kwa mankhwala ofufuza a PLX2853 m'mitu yomwe ili ndi zovuta zoyipa.

Malo: malo awiri

Yttrium90, Ipilimumab, & Nivolumab for Uveal Melanoma With Liver Metastases

Malipoti mpaka pano akuwonetsa kuchepa kwa chitetezo cha mthupi cha uveal melanoma. Umboni waposachedwa woyesa komanso wamankhwala akuwonetsa mgwirizano pakati pa mankhwala a radiation ndi immunotherapy. Ofufuzawa adzafufuzanso mgwirizanowu ndi kafukufuku wowoneka wa odwala 26 omwe ali ndi vuto la khansa ya khansa komanso metastases ya hepatic omwe alandire radiation ya SirSpheres Yttrium-90 yotsatira yothandizidwa ndi immunotherapy kuphatikiza kwa ipilimumab ndi nivolumab.

Malo: malo awiri

Pegargiminase, Nivolumab ndi Ipilimumab pochiza odwala omwe ali ndi vutoli mwaukadaulo kapena losasunthika

Gawo ili loyeserera limafufuza zoyipa za pegargiminase, nivolumab ndi ipilimumab pochiza odwala omwe ali ndi melanoma yomwe yafalikira m'malo ena mthupi (patsogolo) kapena yomwe singachotsedwe ndi opaleshoni (yosasinthika). Pegargiminase ikhoza kuyimitsa kukula kwa zotupa mwa kulepheretsa michere ina yofunikira pakukula kwamaselo. Immunotherapy yokhala ndi ma monoclonal antibodies, monga nivolumab ndi ipilimumab, imatha kuthandizira chitetezo chamthupi kulimbana ndi khansa, ndipo imatha kusokoneza kuthekera kwa maselo otupa kukula ndikufalikira. Kupereka pegargiminase, nivolumab ndi ipilimumab kungakhale bwino poyerekeza ndi immunotherapy yokha.

Kumalo: Memorial Sloan Kettering Cancer Center, New York, New York

Mankhwala a Stereotactic Body Radiation Therapy ndi Aflibercept pochiza Odwala omwe ali ndi Melanoma Wowulula

Gawo lachiwiri lachigawochi limafufuza momwe mankhwala opangira ma radiation osakanikirana bwino amagwirira ntchito pochiza odwala omwe ali ndi khansa ya khansa. Mankhwala opatsirana pogwiritsa ntchito mphamvu ya stereotactic amagwiritsa ntchito zida zapadera kuti akhazikitse wodwala ndikupereka cheza ku zotupa mwatsatanetsatane. Njirayi imatha kupha maselo otupa ndi kuchepa pang'ono panthawi yayifupi ndikuwononga pang'ono minofu yabwinobwino. Aflibercept itha kuyimitsa kukula kwa zotupa mwa kulepheretsa michere ina yofunikira pakukula kwamaselo. Kupereka mankhwala owonongera ma radiation otsatiridwa ndi aflibercept atha kugwira ntchito bwino pochiza odwala omwe ali ndi melanoma.

Kumalo: Chipatala cha Thomas Jefferson University, Philadelphia, Pennsylvania

Phunziro la Chitetezo ndi Kuleza Mtima kwa INCAGN02390 mu Select Advanced Malignancies

Cholinga cha phunziroli ndikuwunika chitetezo, kulolerana, komanso kuyambira koyambirira kwa INCAGN02390 mwa omwe akutenga nawo gawo pazosankha zoyipa zapamwamba.

Kumalo: Hackensack University Medical Center, Hackensack, New Jersey

Katemera (6MHP) wokhala ndi CDX-1127 kapena wopanda Chithandizo cha Melanoma Yachigawo IIB-IV

Gawoli I / II limayesa zovuta zake komanso momwe katemera (6MHP) amagwirira ntchito kapena popanda CDX-1127 pochiza khansa ya melanoma ya IIB-IV. Katemera, monga 6MHP, atha kuthandiza thupi kupanga chitetezo chamthupi chokwanira kupha ma cell a chotupa. Immunotherapy yokhala ndi ma monoclonal antibodies, monga CDX-1127, itha kuthandizira chitetezo chamthupi kuthana ndi khansa, ndipo itha kusokoneza kuthekera kwa maselo am'mimba kukula ndikufalikira. Kuyesaku kukuchitika kuti muwone zotsatira za 6MHP zokha komanso kuphatikiza CDX-1127 pakusintha kwa chitetezo cha mthupi.

Kumalo: University of Virginia Cancer Center, Charlottesville, Virginia

Ipilimumab ndi Nivolumab ndi Immunoembolization Pochiza Odwala Omwe Ali ndi Metastatic Uveal Melanoma mu Chiwindi

Gawo lino lachiwiri lachiyeso limaphunzira ipilimumab ndi nivolumab ndi immunoembolization pochiza odwala omwe ali ndi melanoma yomwe yafalikira pachiwindi. Immunotherapy yokhala ndi ma monoclonal antibodies, monga ipilimumab ndi nivolumab, imatha kuthandizira chitetezo chamthupi kulimbana ndi khansa, ndipo imatha kusokoneza kuthekera kwa maselo otupa kukula ndikufalikira. Immunoembolization itha kupha maselo otupa chifukwa chakuchepa kwa magazi ndikupanga chitetezo chamthupi pamagulu am'mimba. Kupatsa ipilimumab ndi nivolumab ndi immunoembolization kumatha kugwira bwino ntchito pochiza odwala omwe ali ndi melanoma.

Kumalo: Chipatala cha Thomas Jefferson University, Philadelphia, Pennsylvania

Cyclophosphamide, Fludarabine, Tumor Kulowetsa Ma Lymphocyte, ndi Aldesleukin pochiza Ophunzira ndi Metastatic Uveal Melanoma

Gawo lachiwiri lachigawochi limafufuza momwe cyclophosphamide, fludarabine, chotupa chimalowerera ma lymphocyte, ndi aldesleukin amagwira ntchito pochiza omwe ali ndi vuto la melanoma lomwe lafalikira m'malo ena m'thupi. Mankhwala omwe amagwiritsidwa ntchito mu chemotherapy, monga cyclophosphamide ndi fludarabine, amagwira ntchito m'njira zosiyanasiyana kuti achepetse kukula kwa zotupa, mwina popha ma cell, powalekanitsa kuti asagawike, kapena poletsa kufalikira. Mimba yolowetsa ma lymphocyte itha kukhala yothandiza pochiza khansa ya khansa. Aldesleukin imatha kuyambitsa ma cell oyera kuti aphe ma cell a melanoma. Kupatsa cyclophosphamide, fludarabine, chotupa cholowerera ma lymphocyte, ndi aldesleukin zitha kupha ma cell ambiri a chotupa.

Kumalo: University of Pittsburgh Cancer Institute (UPCI), Pittsburgh, Pennsylvania

Autologous CD8 + SLC45A2-Specific T Lymphocyte yokhala ndi Cyclophosphamide, Aldesleukin, ndi Ipilimumab pochiza Ophunzira ndi Metastatic Uveal Melanoma

Gawoli Ib likuwunika zoyipa zake ndi kuchuluka kwa ma CD lychocyte (+) SLC45A2 a T lymphocyte akapatsidwa ndi cyclophosphamide, aldesleukin, ndi ipilimumab, ndikuwona momwe amagwirira ntchito pochiza omwe ali ndi vuto la khansa ya melanoma yomwe yafalikira kumalo ena mthupi. Kuti apange ma CD8 + T apadera, ofufuza amasiyanitsa maselo a T omwe amasonkhanitsidwa kuchokera m'magazi omwe amatenga nawo mbali ndikuwachiza kuti athe kulunjika maselo a khansa ya khansa. Maselo a magazi amaperekedwanso kwa omwe akutenga nawo mbali. Izi zimadziwika kuti "kulandila T cell cell" kapena "cell T yolandila". Mankhwala omwe amagwiritsidwa ntchito mu chemotherapy, monga cyclophosphamide, atha kugwira ntchito m'njira zosiyanasiyana poletsa kukula kwa zotupa, mwina pakupha ma cell, kuwaletsa kuti asagawane, kapena kuwaletsa kuti asafalikire. Njira zachilengedwe, monga aldesleukin, gwiritsani ntchito zinthu zopangidwa kuchokera kuzinthu zamoyo zomwe zingalimbikitse chitetezo cha mthupi m'njira zosiyanasiyana ndikuletsa maselo am'mimba kukula. Immunotherapy yokhala ndi ma monoclonal antibodies, monga ipilimumab, imatha kuthandizira chitetezo chamthupi kulimbana ndi khansa, ndipo imatha kusokoneza kuthekera kwa maselo otupa kukula ndikufalikira. Kupereka ma CD lymphocyte a CD8 + SLC45A2 enieni pamodzi ndi cyclophosphamide, aldesleukin, ndi ipilimumab zitha kugwira bwino ntchito pochiza omwe ali ndi melanoma ya metastatic uveal melanoma.

Kumalo: MD Anderson Cancer Center, Houston, Texas

Intravenous and Intrathecal Nivolumab pochiza Odwala omwe ali ndi matenda a Leptomeningeal

Gawo ili lakuyesa kwa I / Ib limafufuza zoyipa ndi kuchuluka kwa intrathecal nivolumab, komanso momwe imagwirira ntchito limodzi ndi intravenous nivolumab pochiza odwala leptomeningeal matenda. Immunotherapy yokhala ndi ma monoclonal antibodies, monga nivolumab, imatha kuthandizira chitetezo chamthupi kulimbana ndi khansa, ndipo imatha kusokoneza kuthekera kwa maselo otupa kukula ndikufalikira.

Kumalo: MD Anderson Cancer Center, Houston, Texas

Nivolumab yokhala ndi Ipilimumab kapena Relatlimab isanachitike Opaleshoni Pochiza Odwala Omwe Ali ndi Gawo IIIB-IV Melanoma Yomwe Ingachotsedwe ndi Opaleshoni

Kafukufukuyu adafufuza momwe nivolumab kapena ipilimumab kapena relatlimab isanachitike opareshoni yothandizira odwala omwe ali ndi melanoma ya IIIB-IV yomwe ingachotsedwe ndi opaleshoni. Immunotherapy yokhala ndi ma monoclonal antibodies, monga nivolumab, ipilimumab, ndi relatlimab, itha kuthandizira chitetezo chamthupi kulimbana ndi khansa, ndipo itha kusokoneza kuthekera kwa maselo otupa kukula ndikufalikira. Kupereka nivolumab yokha kapena kuphatikiza ndi ipilimumab kapena relatlimab isanachitike opaleshoni kumatha kupangitsa chotupacho kukhala chocheperako ndikuchepetsa kuchuluka kwa minofu yofunikira yomwe imayenera kuchotsedwa.

Kumalo: MD Anderson Cancer Center, Houston, Texas

Katemera wa 6MHP ndi Ipilimumab pochiza Odwala omwe ali ndi Melanoma ya Gawo IIA-IV

Gawoli I / II limayesa zotsatira zoyipa za katemera wa peptide 6 (6MHP) ndi ipilimumab ndikuwona momwe amagwirira ntchito pochiza odwala omwe ali ndi khansa ya melanoma ya IIA-IV. Katemera wopangidwa ndi ma peptide, monga katemera wa 6MHP, atha kuthandiza thupi kupanga chitetezo chamthupi chokwanira kupha ma cell a chotupa. Immunotherapy yokhala ndi ma monoclonal antibodies, monga ipilimumab, imatha kuthandizira chitetezo chamthupi kulimbana ndi khansa, ndipo imatha kusokoneza kuthekera kwa maselo otupa kukula ndikufalikira. Sizikudziwika ngati kupereka katemera wa 6MHP ndi ipilimumab kumagwira bwino ntchito pochiza odwala khansa ya khansa.

Kumalo: University of Virginia Cancer Center, Charlottesville, Virginia

Dabrafenib Mesylate, Trametinib, ndi 6 Katemera wa Melanoma Helper Peptide Pochiza Odwala Omwe Ali ndi Gawo IIIB-IV Melanoma

Gawoli I / II limayesa zovuta zake komanso momwe dabrafenib mesylate, trametinib, ndi katemera wa peptide wa 6 wa melanoma amathandizira odwala omwe ali ndi melanoma ya IIIB-IV. Dabrafenib mesylate ndi trametinib zitha kuyimitsa kukula kwamatenda am'matumbo poletsa ma enzyme ena ofunikira kuti maselo akule. Katemera, monga katemera wa peptide wa 6 wa khansa ya khansa ya khansa ya khansa ya khansa ya khansa ya khansa ya khansa, yopangidwa ndi ma peptide ochokera ku mapuloteni a khansa ya khansa ya khansa, imatha kuthandiza thupi kupanga chitetezo chokwanira cha mthupi kupha ma cell a chotupa omwe amafotokoza ma antigen apadera a melanoma. Kupatsa katemera wa dabrafenib, trametinib, ndi 6 wa melanoma wothandizira peptide atha kugwira ntchito bwino pochiza odwala melanoma.

Kumalo: University of Virginia Cancer Center, Charlottesville, Virginia

Sunitinib Malate kapena Valproic Acid Poletsa Metastasis mwa Odwala Okhala Ndi Chiwopsezo chachikulu

Kuyeserera kwachiwiri kwa gawo lachiwirili kumafufuza momwe sunitinib malate kapena valproic acid imagwirira ntchito popewera melanoma yomwe ili pachiwopsezo chachikulu kuti isafalikire mbali zina za thupi. Sunitinib malate ikhoza kuyimitsa kufalikira kwa zizindikilo zakukula m'maselo otupa ndikulepheretsa ma cell amenewa kukula. Valproic acid imatha kusintha mawonekedwe amtundu wina mu uveal melanoma ndikuletsa kukula kwa chotupa.

Kumalo: Chipatala cha Thomas Jefferson University, Philadelphia, Pennsylvania

Tumor Yolowerera Ma Lymphocyte ndi High-Dose Aldesleukin okhala ndi kapena opanda Maselo a Autologous Dendritic pochiza Odwala omwe ali ndi Metastatic Melanoma

Kuyeserera kwachiwiri kwa gawo lachiwirili kumafufuza momwe chotupa cholowerera chimalowerera ma lymphocyte ndi aldesleukin wambiri kapena omwe alibe ma autologous dendritic cell amagwira ntchito pochiza odwala khansa ya khansa yomwe yafalikira kumadera ena a thupi. Katemera wopangidwa ndi chotupa cha munthu ndi maselo apadera am'magazi (ma dendritic cell) atha kuthandiza thupi kupanga chitetezo chamthupi chokwanira kupha ma cell a chotupa. Aldesleukin imatha kuyambitsa maselo oyera am'magazi kuti aphe zotupa. Sizikudziwika ngati chotupa cholowerera chomwe chimalowetsa ma lymphocyte ndi aldesleukin wothandiziranso kwambiri chimakhala chothandiza mukamapereka limodzi kapena opanda maselo am'madzi akuchepa kapena kuchepetsa kukula kwa khansa ya khansa. Ubwino wazachipatala wolandila ma lymphocyte (TIL) ophatikizana ndi B-Raf proto-oncogene, serine / threonine kinase (BRAF) inhibitor iphunziridwa, kwa odwala omwe ali ndi matenda opita patsogolo (PD) pogwiritsa ntchito BRAF inhibitor asanafike chithandizo cha TIL. Matenda a Leptomeningeal (LMD) mwatsoka ndi chitukuko chofala kwa odwala omwe ali ndi khansa ya khansa, omwe ali ndi vuto lodziwikiratu, zomwe zimapangitsa kuti pakhale milungu ingapo. Ndi njira yatsopano yophatikizira ma TILs a intrathecal ndi intrathecal interleukin (IL) -2, ofufuza akuyembekeza kuyambitsa matenda azolimbitsa thupi kapena kukhululukidwa kwa LMD.

Kumalo: MD Anderson Cancer Center, Houston, Texas

Vorinostat Yothandizira Matenda Oopsa a Kalasi Yachiwiri

Gawo loyambirira la mayesowa ndikuwunika momwe vorinostat imagwirira ntchito pochiza odwala omwe ali ndi chiopsezo chachikulu cha khansa ya khansa (diso). Ofufuza apeza kuti ma cell a uveal melanomas amagawika m'magulu awiri: gulu 1 ndi kalasi 2. Maselo a class 2 amakhala ndi mwayi wopita ku ziwalo zina m'thupi, pomwe khungu la 1 limakhala makamaka diso. Vorinostat atha kusintha maselo a 2 kukhala magulu amtundu wosautsa kwambiri mwa "kuyatsa" majini omwe ali mchipindacho omwe amapondereza zotupa.

Kumalo: University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami, Florida

Ulixertinib pochiza odwala omwe ali ndi gawo lachisanu ndi chiwiri lotulutsa khansa ya pakhungu

Gawo lino lachiwiri limawunika zoyipa za ulixertinib ndi momwe zimagwirira ntchito pochiza odwala omwe ali ndi khansa ya melanoma ya IV. Ulixertinib ikhoza kuyimitsa kukula kwa zotupa potseka ma enzyme ena omwe amafunikira kuti maselo akule.

Kumalo: Onani Clinical Trials.gov

Vorinostat pochiza odwala omwe ali ndi khansa yapakhungu ya m'maso

Gawo ili lachiwiri limawunika momwe vorinostat imagwirira ntchito pochiza odwala khansa ya khansa ya m'maso yomwe yafalikira mbali zina za thupi. Vorinostat ikhoza kuletsa kukula kwa zotupa m'matumbo mwa kutseka ma enzyme ena ofunikira kuti maselo akule.

Kumalo: Onani Clinical Trials.gov