Pafupifupi-khansa / chithandizo / mayesero azachipatala / matenda / khansa ya kumatako / chithandizo

Chithandizo Chachipatala Kuyesedwa kwa Khansa ya Anal

Mayesero azachipatala ndi maphunziro ofufuza omwe amakhudza anthu. Mayeso azachipatala pamndandandawu ndi omwe amathandizira khansa ya kumatako. Mayesero onse pamndandanda amathandizidwa ndi NCI.

Zambiri za NCI zokhudzana ndi mayesero azachipatala zimafotokozera mitundu ndi magawo am'mayesero ndi momwe amachitikira. Mayesero azachipatala amayang'ana njira zatsopano zotetezera, kuzindikira, kapena kuchiza matenda. Mungafune kuganizira zokhala ndi gawo pakuyesedwa kwachipatala. Lankhulani ndi dokotala wanu kuti akuthandizeni kusankha ngati mukuyenera.

Mayesero 1-23 a 23

Nivolumab pambuyo pa Mgwirizano Wophatikiza Pazithandizo Pochiza Odwala Omwe Ali Ndi Ngozi Yaikulu II-IIIB Cancer

Kafukufukuyu adafufuza momwe nivolumab atagwirira ntchito limodzi pochiza odwala omwe ali pachiwopsezo chachikulu cha khansa yachiwiri ya II-IIIB. Immunotherapy yokhala ndi ma monoclonal antibodies, monga nivolumab, imatha kuthandizira chitetezo chamthupi kulimbana ndi khansa, ndipo imatha kusokoneza kuthekera kwa maselo otupa kukula ndikufalikira.

Malo: malo 744

Nivolumab wokhala ndi Ipilimumab kapena wopanda Pochiza Odwala Omwe Ali Ndi Refractory Metastatic Anal Canal Cancer

Gawo lachiwiri lachiyeso limafufuza momwe nivolumab yokhala ndi kapena yopanda ipilimumab imagwira ntchito pochiza odwala omwe ali ndi khansa ya canal canal yomwe sanayankhe mankhwala am'mbuyomu (refractory) ndipo afalikira m'malo ena mthupi (metastatic). Immunotherapy yokhala ndi ma monoclonal antibodies, monga nivolumab ndi ipilimumab, imatha kuthandizira chitetezo chamthupi kulimbana ndi khansa, ndipo imatha kusokoneza kuthekera kwa maselo otupa kukula ndikufalikira.

Malo: malo 42

Nivolumab ndi Ipilimumab pochiza Odwala omwe ali ndi kachilombo ka HIV kamene kamabwereranso kapena kachilombo koyambitsa matenda a Hodgkin Lymphoma kapena zotupa zolimba zomwe zimatha kapena kuchotsedwa ndi opaleshoni

Gawo ili loyeserera limafufuza zoyipa ndi mankhwala abwino kwambiri a nivolumab akamaperekedwa ndi ipilimumab pochiza odwala omwe ali ndi kachilombo ka HIV (HODgkin lymphoma) yomwe yabwerera pambuyo poti yasintha kapena siyiyankha chithandizo, kapena zotupa zolimba zomwe zafalikira m'malo ena m'thupi kapena sizingachotsedwe ndi opaleshoni. Immunotherapy yokhala ndi ma monoclonal antibodies, monga ipilimumab ndi nivolumab, imatha kuthandizira chitetezo chamthupi kulimbana ndi khansa, ndipo imatha kusokoneza kuthekera kwa maselo otupa kukula ndikufalikira. Ipilimumab ndi mankhwala omwe amatsutsana ndi molekyulu yotchedwa cytotoxic T-lymphocyte antigen 4 (CTLA-4). CTLA-4 imayang'anira gawo lina la chitetezo chamthupi mwanu potseka. Nivolumab ndi mtundu wa antibody womwe umafotokoza za kufa kwa cell 1 (PD-1), puloteni yomwe imayambitsa kuwonongeka kwa maselo amthupi. Kupatsa ipilimumab ndi nivolumab kumatha kugwira ntchito bwino pochiza odwala omwe ali ndi kachilombo ka HIV komwe kumalumikizidwa ndi Hodgkin lymphoma kapena zotupa zolimba poyerekeza ndi ipilimumab yokhala ndi nivolumab yokha.

Malo: malo 28

Phunziro la XmAb®20717 mu Ophunzira Omwe Ali Ndi Zotupa Zapamwamba Zolimba

Ili ndi gawo 1, kuchuluka kwa kuchuluka, kukwera kwa kuchuluka kwa kuchuluka kwa kuchuluka kwa MTD / RD ndi mtundu wa XmAb20717, kufotokoza chitetezo ndi kulolerana, kuyesa PK ndi immunogenicity, ndikuwunikiranso ntchito zotsutsana ndi zotupa za XmAb20717 m'mitu yomwe yasankhidwa zotupa zolimba zotsogola.

Malo: malo 15

Kafukufuku Wofufuza za Immuno-Therapy Kafukufuku Wofufuza Chitetezo ndi Kuchita Bwino kwa Nivolumab, ndi Nivolumab Combination Therapy mu Zotupa zogwirizana ndi Virus

Cholinga cha kafukufukuyu kuti afufuze chitetezo cha nivolumab, ndi nivolumab kuphatikiza mankhwala, kuti athandize odwala omwe ali ndi zotupa zokhudzana ndi ma virus. Ma virus ena amadziwika kuti amatenga gawo pakapangidwe kazotupa ndikukula. Kafukufukuyu adzafufuza zotsatira zamankhwalawa, kwa odwala omwe ali ndi zotupa zotsatirazi: - Khansa ya canal ya Canal-Osalembetsanso chotupachi - Khansa ya pachibelekero - Epstein Barr Virus (EBV) khansa ya m'mimba yabwino-Osatinso izi Mtundu wa chotupa - Khansa ya Merkel - Khansa ya Penile-Kulembetsanso mtundu uwu wa khansa - Khansa ya m'mimba ndi ya vulvar-Simulembetsanso chotupachi - Khansa ya Nasopharyngeal - Simulembetsanso chotupachi - Khansa ya Mutu ndi Khosi - Simulembetsanso chotupachi

Malo: malo 10

Kafukufuku wa Pembrolizumab (MK-3475) mwa Ophunzira Ndi Mafupa Olimba Kwambiri (MK-3475-158 / KEYNOTE-158)

Phunziroli, omwe ali ndi mitundu ingapo ya zotupa zolimba (zosasunthika komanso / kapena metastatic) zomwe zapita patsogolo pa chithandizo chamankhwala amathandizidwa ndi pembrolizumab.

Malo: Malo 8

High-Dose-Rate Brachytherapy ndi Chemotherapy Pochiza Odwala Omwe Ali Ndi Recurrent kapena Residual Rectal kapena Anal Cancer Omwe Akuyang'anira Osagwira Ntchito

Gawo ili loyeserera limafufuza zoyipa ndi kuchuluka kwa mankhwala a brachytherapy operekedwa limodzi ndi chemotherapy pochiza odwala khansa ya m'mimba kapena yam'mbuyo yomwe yabwerera kapena ikukulirakulira ndipo sangathe kuchiritsidwa ndi opaleshoni. Brachytherapy, yomwe imadziwikanso kuti radiation radiation yamkati, imagwiritsa ntchito zida zowulutsa ma radio zomwe zimayikidwa mkati kapena pafupi ndi chotupa kuti iphe ma cell a chotupa. Brachytherapy ya mulingo wambiri (HDR) imagwiritsa ntchito zida zowulutsa ma radio kuti ipereke chiwopsezo chachikulu cha radiation mu kanthawi kochepa ku chotupacho. Itha kutumizanso ma radiation ochepa kumatenda oyandikana nawo omwe ali pafupi ndipo imachepetsa zovuta zoyipa. Mankhwala omwe amagwiritsidwa ntchito mu chemotherapy, monga capecitabine ndi fluorouracil, amagwira ntchito m'njira zosiyanasiyana kuti achepetse kukula kwa zotupa, mwina popha ma cell, powalekanitsa kuti asagawike, kapena poletsa kufalikira.

Malo: 6 malo

Pembrolizumab pochiza odwala omwe ali ndi khansa ya m'mimba kapena yapafupi yomwe singathe kuchotsedwa ndi opareshoni

Gawo ili lachiwiri limawunika momwe pembrolizumab imagwirira ntchito pochiza odwala khansa ya m'mimba yomwe yafalikira m'malo ena mthupi kapena yomwe yafalikira kuchokera komwe idakulira mpaka kumatumbo kapena ma lymph node ndipo sangachotsedwe ndi opareshoni. Immunotherapy yokhala ndi ma monoclonal antibodies, monga pembrolizumab, imatha kuthandizira chitetezo chamthupi kulimbana ndi khansa, ndipo imatha kusokoneza kuthekera kwa maselo otupa kukula ndikufalikira.

Malo: 5 malo

Opaleshoni Pochiza Odwala Omwe Ali Ndi Gawo Loyambira Anal Canal kapena Perianal Cancer ndi HIV Positive

Gawo ili lachiwiri lakuyesa opareshoni pochiza odwala omwe ali ndi khansa ya anal kapena khansa ya perianal yomwe ndi yaying'ono ndipo siyinafalikire kwambiri kumatenda ndi kachilombo ka HIV. Kuchita opaleshoni kwanuko kumatha kukhala mankhwala otetezeka osakhala ndi zotsatirapo zochepa kuposa opaleshoni yayikulu kapena radiation ndi chemotherapy.

Malo: 5 malo

Kuyesa Kupeza ndi Kufufuza Mlingo Wosungika wa Zinthu Zatsopano (BI 754091) kwa Odwala Omwe Ali Ndi Zotupa Zolimba

Cholinga chachikulu cha gawo loyesa kuchuluka kwa mayeserowa ndikuwunika chitetezo ndi kulolerana, ndikuwona Maximum Tolerated Dose ndi / kapena Recommended Phase 2 Dose (RP2D) ya BI 754091 pamaziko a odwala omwe ali ndi malire ochezera toxicities (DLTs) mwa odwala omwe ali ndi vuto loyipa. Chitetezo ndi kulolerana zidzawunikidwa poyang'anira zochitika zosawoneka bwino (AEs), AEs zazikulu (SAE), ndi zovuta zamalabotale, komanso kusintha kwa zizindikilo zofunika. Zolinga zachiwiri ndikutsimikiza kwa mbiri ya PK ya BI 754091 pambuyo pa kuchuluka kwa BI 754091 kamodzi, ndikuwunika koyambirira kwa ntchito zotsutsana. Mu gawo lokulitsa mlingo wa mayeserowo, zolinga zazikulu ndikuwunikanso za chitetezo, mphamvu, mbiri ya PK,

Malo: malo atatu

Stereotactic Radiosurgery Pochiza Odwala omwe Ali ndi Matenda a Oligometastatic

Gawo ili lachiwiri limawunika momwe ma radiosurgery amagwirira ntchito pochiza odwala khansa omwe afalikira mpaka 5 kapena malo ochepa mthupi ndipo amakhala ndi ziwalo zitatu kapena zochepa (matenda a oligometastatic). Stereotactic radiosurgery, yomwe imadziwikanso kuti stereotactic radiation radiation Therapy, ndi njira yapadera yochizira ma radiation yomwe imapereka radiation imodzi, yayikulu kwambiri pachotupa ndipo imatha kupha ma cell ambiri otupa ndikuwononga pang'ono minofu yabwinobwino.

Malo: malo atatu

Kafukufuku wa INCMGA00012 ku Squamous Carcinoma of the Can Canal Pambuyo pa Platinum-based Chemotherapy (POD1UM-202)

Cholinga cha phunziroli ndikuwunika momwe INCMGA00012 imagwirira ntchito mwa omwe ali nawo pachimake cha metalatic squamous carcinoma ya canal (SCAC) omwe apita patsogolo pambuyo pa chemotherapy yochokera ku platinamu.

Malo: 4 malo

Artesunate pochiza Odwala omwe ali ndi High-grade Anal Intraepithelial Neoplasia

Gawo ili loyeserera limafufuza zoyipa ndi kuchuluka kwa artesunate pochiza odwala omwe ali ndi msinkhu wapamwamba wa intraepithelial neoplasia. Anal intraepithelial neoplasia ndi maselo osakhazikika omwe atha kukhala khansa m'tsogolo. Zosintha zambiri zomwe zimayambitsa khansa zimayambitsidwa ndi papillomavirus ya anthu (HPV). Artesunate amatha kupha maselo omwe ali ndi HPV.

Malo: malo awiri

Kafukufuku wa LY3434172, PD-1 ndi PD-L1 Bispecific Antibody, mu Advanced Cancer

Cholinga chachikulu cha kafukufukuyu ndikuwunika chitetezo ndi kulolerana kwa mankhwala ophunzirira a LY3434172, anti-PD-1 / PD-L1 bispecific antibody, mwa omwe ali ndi zotupa zolimba.

Kumalo: MD Anderson Cancer Center, Houston, Texas

SL-279252 (PD1-Fc-OX40L) mwa Omwe Ali Ndi Zotupa Zolimba Kwambiri kapena Ma Lymphomas

Ili ndiye gawo 1 loyamba mwa anthu, lotseguka, pakati, kuchuluka kwa kuchuluka kwa kuchuluka kwa kuchuluka kwa kuchuluka kwa zotupa kapena zotupa za SL-279252 m'mitu yomwe ili ndi zotupa zolimba kapena ma lymphomas. .

Kumalo: MD Anderson Cancer Center, Houston, Texas

LET-IMPT ndi Standard Chemotherapy Pochiza Odwala Omwe Ali Ndi Gawo Latsopano I-III Anal Canal Squamous Cell Cancer

Gawo lachiwiri lachigawochi limafufuza zoyipa za LET-IMPT ndi chemotherapy yokhazikika, komanso momwe amagwirira ntchito pochiza odwala omwe ali ndi khansa yaposachedwa ya I-III canal squamous cell. LET-IMPT ndi mtundu wa mankhwala a radiation omwe amagwiritsa ntchito mphamvu yayikulu "proton" kuti "ajambule" kuchuluka kwa radiation mu chandamale ndipo chitha kuthandiza kupha ma cell a zotupa ndikuchepetsa zotupa. Kupatsa LET-IMPT ndi chemotherapy yokhazikika kumatha kugwira ntchito bwino pochiza odwala omwe ali ndi khansa ya m'mimba ya squamous cell.

Kumalo: MD Anderson Cancer Center, Houston, Texas

VGX-3100 ndi Electroporation pochiza Odwala omwe ali ndi HIV-Positive High-grade Anal zilonda

Gawo ili lachiwiri limawunika momwe papillomavirus (HPV) ya deoxyribonucleic acid (DNA) ya plasmids katemera wothandizira VGX-3100 (VGX-3100) ndi ntchito yamagetsi yochizira odwala omwe ali ndi zotupa za HIV. Katemera wopangidwa kuchokera ku DNA atha kuthandiza thupi kupanga chitetezo chamthupi chokwanira kupha ma cell a chotupa. Kusungunula magetsi kumathandiza ma pores m'maselo amthupi mwanu kuti alowetse mankhwalawa kuti alimbikitse kuyankha kwa chitetezo chamthupi. Kupereka VGX-3100 ndikuwonjezera magetsi pamodzi kungagwire bwino ntchito pochiza odwala omwe ali ndi zotupa zamatenda apamwamba.

Malo: malo awiri

DNA Plasmid-encoding Interleukin-12 / HPV DNA Plasmids Vaccine Vaccine INO-3112 ndi Durvalumab pochiza Odwala omwe ali ndi khansa ya Recurrent kapena Metastatic Human Papillomavirus Associated

Gawo ili lachiwiri limawunika momwe deoxyribonucleic acid (DNA) plasmid-encoding interleukin-12 / human papillomavirus (HPV) DNA plasmids vaccine vaccine INO-3112 ndi durvalumab amagwira ntchito pochiza odwala khansa ya papillomavirus ya khansa yomwe yabwerera kapena kufalikira kwa ena malo mthupi. Katemera wopangidwa kuchokera ku kachilombo kosinthidwa ndi jini atha kuthandiza thupi kupanga chitetezo chokwanira chamthupi kupha ma cell a chotupa. Immunotherapy yokhala ndi ma monoclonal antibodies, monga durvalumab, itha kuthandizira chitetezo chamthupi kuthana ndi khansa, ndipo itha kusokoneza kuthekera kwa maselo otupa kukula ndikufalikira. Kupereka DNA plasmid-encoding interleukin-12 / HPV DNA plasmids katemera wothandizira INO-3112 ndi durvalumab zitha kugwira bwino ntchito pochiza odwala khansa ya papillomavirus ya anthu.

Kumalo: MD Anderson Cancer Center, Houston, Texas

M7824 mkati mwa Omwe Ali ndi HPV Associated Malignancies

Chiyambi: Ku United States, chaka chilichonse pamakhala milandu yopitilira 30,000 ya khansa yolumikizidwa ndi papillomavirus (HPV). Ena mwa khansa imeneyi nthawi zambiri imakhala yosachiritsika ndipo siyimasulidwa ndi mankhwala wamba. Ochita kafukufuku akufuna kuwona ngati mankhwala atsopano a M7824, omwe amayang'ana ndikuletsa njira yomwe imalepheretsa chitetezo cha mthupi kuthana ndi khansa imatha kuchepetsa zotupa mwa anthu omwe ali ndi khansa ya HPV. Zolinga: Kuwona ngati mankhwala a M7824 amayambitsa zotupa. Kuvomerezeka: Akuluakulu azaka 18 kapena kupitilira apo omwe ali ndi khansa yokhudzana ndi matenda a HPV. Kupanga: Ophunzira adzayang'aniridwa ndi mbiri yazachipatala ndikuwunika kwakuthupi. Adzawunikanso zisonyezo zawo ndi momwe amachitila zinthu zachilendo. Adzakhala ndi mawonekedwe a thupi. Adzapereka zitsanzo zamagazi ndi mkodzo. Adzalandira zitsanzo za chotupa chawo ngati sichipezeka. Ophunzira adzakhala ndi pulogalamu yamagetsi younikira mtima wawo. Kenako amalandira mankhwalawa kudzera mu chubu chochepa kwambiri mumitsempha ya mkono. Ophunzira adzalandira mankhwalawa milungu iwiri iliyonse kwa nthawi 26 (chaka chimodzi). Iyi ndi njira ya 1. Pambuyo pa maphunzirowa, ophunzirawo ayang'aniridwa koma satenga mankhwalawa. Matenda awo akafika poipa, ayamba maphunziro ena ndi mankhwalawa. Izi zitha kubwerezedwa kangapo momwe zingafunikire. Chithandizo chitha ngati wophunzirayo ali ndi zovuta zina kapena mankhwalawa atasiya kugwira ntchito. Pakafukufuku wonse, ophunzira athe kubwereza mayeso ena kapena mayeso onse owunikira. Ophunzira atasiya kumwa mankhwalawo, adzawayendera ndikubwereza mayeso ena owunika. Adzalandira mafoni otsatirawa nthawi ndi nthawi. ... Kenako amalandira mankhwalawa kudzera mu chubu chochepa kwambiri mumitsempha ya mkono. Ophunzira adzalandira mankhwalawa masabata awiri aliwonse maulendo 26 (chaka chimodzi). Iyi ndi njira ya 1. Pambuyo pa maphunzirowa, ophunzirawo ayang'aniridwa koma satenga mankhwalawa. Matenda awo akafika poipa, ayamba maphunziro ena ndi mankhwalawa. Izi zitha kubwerezedwa kangapo momwe zingafunikire. Chithandizo chitha ngati wophunzirayo ali ndi zovuta zina kapena mankhwalawa atasiya kugwira ntchito. Pakafukufuku wonse, ophunzira athe kubwereza mayeso ena kapena mayeso onse owunikira. Ophunzira atasiya kumwa mankhwalawo, adzawayendera ndikubwereza mayeso ena owunika. Adzalandira mafoni otsatirawa nthawi ndi nthawi. ... Kenako amalandira mankhwalawa kudzera mu chubu chochepa kwambiri mumitsempha ya mkono. Ophunzira adzalandira mankhwalawa milungu iwiri iliyonse kwa nthawi 26 (chaka chimodzi). Iyi ndi njira ya 1. Pambuyo pa maphunzirowa, ophunzirawo ayang'aniridwa koma satenga mankhwalawa. Matenda awo akafika poipa, ayamba maphunziro ena ndi mankhwalawa. Izi zitha kubwerezedwa kangapo momwe zingafunikire. Chithandizo chitha ngati wophunzirayo ali ndi zovuta zina kapena mankhwalawa atasiya kugwira ntchito. Pakafukufuku wonse, ophunzira athe kubwereza mayeso ena kapena mayeso onse owunikira. Ophunzira atasiya kumwa mankhwalawo, adzawayendera ndikubwereza mayeso ena owunika. Adzalandira mafoni otsatirawa nthawi ndi nthawi. ... ophunzira ayang'aniridwa koma satenga mankhwalawa. Matenda awo akafika poipa, ayamba maphunziro ena ndi mankhwalawa. Izi zitha kubwerezedwa kangapo momwe zingafunikire. Chithandizo chitha ngati wophunzirayo ali ndi zovuta zina kapena mankhwalawa atasiya kugwira ntchito. Pakafukufuku wonse, ophunzira athe kubwereza mayeso ena kapena mayeso onse owunikira. Ophunzira atasiya kumwa mankhwalawo, adzawayendera ndikubwereza mayeso ena owunika. Adzalandira mafoni otsatirawa nthawi ndi nthawi. ... ophunzira ayang'aniridwa koma satenga mankhwalawa. Matenda awo akafika poipa, ayamba maphunziro ena ndi mankhwalawa. Izi zitha kubwerezedwa kangapo momwe zingafunikire. Chithandizo chitha ngati wophunzirayo ali ndi zovuta zina kapena mankhwalawa atasiya kugwira ntchito. Pakafukufuku wonse, ophunzira athe kubwereza mayeso ena kapena mayeso onse owunikira. Ophunzira atasiya kumwa mankhwalawo, adzawayendera ndikubwereza mayeso ena owunika. Adzalandira mafoni otsatirawa nthawi ndi nthawi. ... Ophunzira atasiya kumwa mankhwalawo, adzawayendera ndikubwereza mayeso ena owunika. Adzalandira mafoni otsatirawa nthawi ndi nthawi. ... Ophunzira atasiya kumwa mankhwalawo, adzawayendera ndikubwereza mayeso ena owunika. Adzalandira mafoni otsatirawa nthawi ndi nthawi. ...

Kumalo: National Institutes of Health Clinical Center, Bethesda, Maryland

MnSOD Mimetic BMX-001 pochiza Odwala omwe ali ndi khansa ya Anal yomwe imalandira chithandizo cha radiation ndi chemotherapy

Gawo ili loyeserera limayesa kuchuluka kwabwino kwa MnSOD mimetic BMX-001 kuti ichepetse zovuta zomwe zimadwala khansa ya anal yomwe imalandira chithandizo chama radiation ndi chemotherapy. Mankhwala osokoneza bongo, monga BMX-001, amatha kuteteza maselo abwinobwino pazoyambitsa chemotherapy pomwe amalimbikitsa kupha chotupa.

Kumalo: University of Nebraska Medical Center, Omaha, Nebraska

Atezolizumab ndi Bevacizumab pochiza Odwala omwe ali ndi zotupa zokhazikika

Gawo ili lachiwiri limawunika momwe atezolizumab ndi bevacizumab amagwira ntchito pochiza odwala omwe ali ndi zotupa zolimba kwambiri. Immunotherapy yokhala ndi ma monoclonal antibodies, monga atezolizumab ndi bevacizumab, imatha kuthandizira chitetezo chamthupi kulimbana ndi khansa, ndipo imatha kusokoneza kuthekera kwa maselo otupa kukula ndikufalikira.

Kumalo: MD Anderson Cancer Center, Houston, Texas

Therapy Vaccine ndi Cyclophosphamide Pochiza Odwala omwe ali ndi HLA-A * 02 Yabwino Yobwereranso, Yotsutsa, kapena Metastatic HPV16-Yokhudzana ndi Oropharyngeal, Cervical, kapena Cancer Cancer

Gawoli Ib / II yoyeserera limafufuza zoyipa ndi mankhwala abwino a HPV16-E711-19 katemera wa nanomer DPX-E7 ndikuwona momwe imagwirira ntchito bwino akapatsidwa limodzi ndi cyclophosphamide pochiza odwala omwe ali ndi kachilombo ka HLA-A * 02, papillomavirus 16 ( HPV16) yokhudzana ndi oropharyngeal, khomo lachiberekero, kapena khansa ya kumatako yomwe yabwerera, siyiyankha chithandizo, kapena yafalikira mbali zina za thupi. Katemera wopangidwa kuchokera ku kachilombo kosinthidwa ndi jini atha kuthandiza thupi kupanga chitetezo chokwanira chamthupi kupha ma cell a chotupa. Mankhwala omwe amagwiritsidwa ntchito mu chemotherapy, monga cyclophosphamide, amagwira ntchito m'njira zosiyanasiyana kuti achepetse kukula kwa zotupa, mwina popha ma cell, powalekanitsa kuti asagawane, kapena poletsa kufalikira. Kupatsa katemera wa HPV16-E711-19 nanomer DPX-E7 limodzi ndi cyclophosphamide zitha kugwira bwino ntchito pochiza odwala omwe ali ndi HPV16 oropharyngeal,

Kumalo: Dana-Farber Cancer Institute, Boston, Massachusetts

Nivolumab ndi Ipilimumab pochiza odwala omwe ali ndi zotupa zambiri

Gawo ili lachiwiri lachiyeso limafufuza nivolumab ndi ipilimumab pochiza odwala omwe ali ndi zotupa zochepa. Immunotherapy yokhala ndi ma monoclonal antibodies, monga nivolumab ndi ipilimumab, imatha kuthandizira chitetezo chamthupi kulimbana ndi khansa, ndipo imatha kusokoneza kuthekera kwa maselo otupa kukula ndikufalikira. Mlanduwu umalembetsa otenga nawo mbali m'magulu otsatirawa potengera izi: 1. Zotupa zam'mimba zam'mimbamo, zotupa m'mimba, nasopharynx: A) Squamous cell carcinoma yokhala ndi mphuno, sinus, ndi nasopharynx ndi trachea (kupatula khansa ya khosi, nasopharyngeal [NPC] , ndi squamous cell carcinoma ya mutu ndi khosi [SCCHN]) B) Adenocarcinoma ndi mitundu ina yammphuno, sinus, ndi nasopharynx (yotseka mpaka kuchuluka kwa 07/27/2018) 2. Zotupa zam'mimba zamatenda akulu am'matumbo (otsekedwa mpaka kuwonjezeranso 03 / 20/2018) 3. Matumbo amtundu wa salivary otupa pamutu ndi m'khosi, milomo, kum'mero, m'mimba, trachea ndi mapapo, bere ndi malo ena (otsekedwa mpaka okwanira) 4. Carcinoma yosadziwika ya thirakiti (GI) 5. Adenocarcinoma yokhala ndi m'matumbo ang'onoang'ono (otsekedwa mpaka opezekapo) 05/10/2018) 6. Squamous cell carcinoma yokhala ndimatenda osiyanasiyana a GI (m'mimba matumbo ang'ono, m'matumbo, m'matumbo, kapamba) (yotseka mpaka 10/17/2018) 7. Fibromixoma ndi low grade mucinous adenocarcinoma (pseudomixoma peritonei) ya zowonjezerazo ndi ovary (kutsekedwa mpaka kuwonjezerapo 03/20/2018) 8. Zotupa zambiri za pancreatic kuphatikiza acinar cell carcinoma, mucinous cystadenocarcinoma kapena serous cystadenocarcinoma. Pancreatic adenocarcinoma siyoyenera 9. Intrahepatic cholangiocarcinoma (yotseka mpaka kuchuluka kwa 03/20/2018) 10. Extrahepatic cholangiocarcinoma ndi zotupa za bile (zotsekedwa mpaka kuwonjezeka 03/20/2018) 11. Sarcomatoid carcinoma ya m'mapapo 12. Bronchoalveolar carcinoma lung. Matendawa amadziwikanso kuti adenocarcinoma in situ, adenocarcinoma yocheperako, adenocarcinoma, kapena adidocarcinoma 13. Wotupa wa ovary B: A) Chifuwa cha khungu la ovary B) chotupa chosakanikirana ndi adenosarcoma (chatsekedwa chatsekedwa) mpaka kuwonjezeka 03/30/2018) 14. Chotupa cha trophoblastic: A) Choriocarcinoma (chatsekedwa mpaka kuwonjezeka 04/15/2019) 15. Transitional cell carcinoma kupatula ya impso, m'chiuno, ureter, kapena chikhodzodzo (yotsekedwa mpaka kuchuluka kwa 04 / 15/2019) 16. Chotupa chama cell cha ma testes ndi zotupa za majeremusi a extragonadal: Zotupa za Apocrine / extramammary Matenda a Paget 40. Peritoneal mesothelioma 41. Basal cell carcinoma 42. Chotsani khansa ya khomo lachiberekero 43. Esthenioneuroblastoma 44. Endometrial carcinosarcoma (zopweteka zosakanikirana zotupa za Mullerian) (zotsekedwa mpaka zowonjezera) 45. Chotsani khansa ya m'mimba ya endometrial 46. Chotsani khungu khansa yamchiberekero 47. Matenda a Gestational trophoblastic (GTD) 48. Gallbladder cancer 49. Small cell carcinoma of the ovary, hypercalcemic type 50. PD-L1 amplified tumors 51. Angiosarcoma 52. High-grade neuroendocrine carcinoma (pancreatic neuroendocrine chotupa [PNET] ayenera kulembetsa nawo Cohort 22; ma prostatic neuroendocrine carcinomas ayenera kulembetsa nawo Cohort 53). Khansa ya m'mapapo yaying'ono siyoyenera 53. Khansa-yotuluka yaing'ono-cell neuroendocrine prostate khansa (t-SCNC) Chotsani khansa ya pachibelekeropo 43. Esthenioneuroblastoma 44. Endometrial carcinosarcoma (zotupa zosakanikirana zotupa za Mullerian) (zotsekedwa mpaka kuwonjezeka) 45. Chotsani khansa ya m'mimba ya endometrial 46. Chotsani khansa yamchiberekero yama cell 47. Matenda a Gestational trophoblastic (GTD) 48. Khansa ya m'mimba 49. Small cell carcinoma ya ovary, mtundu wa hypercalcemic 50. PD-L1 yotulutsa zotupa 51. Angiosarcoma 52. Neuroendocrine carcinoma (pancreatic neuroendocrine tumor [PNET] iyenera kulembedwa mu Cohort 22; ma prostatic neuroendocrine carcinomas ayenera kulembedwa mu Cohort 53). Khansa ya m'mapapo yaying'ono siyoyenera 53. Khansa-yotuluka yaing'ono-cell neuroendocrine prostate khansa (t-SCNC) Chotsani khansa ya pachibelekeropo 43. Esthenioneuroblastoma 44. Endometrial carcinosarcoma (zotupa zosakanikirana zotupa za Mullerian) (zotsekedwa mpaka kuwonjezeka) 45. Chotsani khansa ya m'mimba ya endometrial 46. Chotsani khansa yamchiberekero yama cell 47. Matenda a Gestational trophoblastic (GTD) 48. Khansa ya m'mimba 49. Small cell carcinoma ya ovary, mtundu wa hypercalcemic 50. PD-L1 yotulutsa zotupa 51. Angiosarcoma 52. Neuroendocrine carcinoma (pancreatic neuroendocrine tumor [PNET] iyenera kulembedwa mu Cohort 22; ma prostatic neuroendocrine carcinomas ayenera kulembedwa mu Cohort 53). Khansa ya m'mapapo yaying'ono siyoyenera 53. Khansa-yotuluka yaing'ono-cell neuroendocrine prostate khansa (t-SCNC) Chotsani khansa yamchiberekero cha m'mimba 47. Matenda a Gestational trophoblastic (GTD) 48. Khansa ya m'matumbo 49. Kansa yaying'ono ya ovary, mtundu wa hypercalcemic 50. PD-L1 amatulutsa zotupa 51. Angiosarcoma 52. Neuroendocrine carcinoma (chotupa cha pancreatic neuroendocrine [PNET ] ayenera kulembedwa mu Cohort 22; ma prostatic neuroendocrine carcinomas ayenera kulembedwa mu Cohort 53). Khansa ya m'mapapo yaying'ono siyoyenera 53. Khansa-yotuluka yaing'ono-cell neuroendocrine prostate khansa (t-SCNC) Chotsani khansa yamchiberekero cha m'mimba 47. Matenda a Gestational trophoblastic (GTD) 48. Khansa ya m'matumbo 49. Kachilombo kakang'ono kakang'ono ka ovary, mtundu wa hypercalcemic 50. PD-L1 amatulutsa zotupa 51. Angiosarcoma 52. Neuroendocrine carcinoma (chotupa cha pancreatic neuroendocrine [PNET ] ayenera kulembedwa mu Cohort 22; ma prostatic neuroendocrine carcinomas ayenera kulembedwa mu Cohort 53). Khansa ya m'mapapo yaying'ono siyoyenera 53. Khansa-yotuluka yaing'ono-cell neuroendocrine prostate khansa (t-SCNC) Prostatic neuroendocrine carcinomas iyenera kulembedwa mu Cohort 53). Khansa ya m'mapapo yaying'ono siyoyenera 53. Khansa-yotuluka yaing'ono-cell neuroendocrine prostate khansa (t-SCNC) Prostatic neuroendocrine carcinomas iyenera kulembedwa mu Cohort 53). Khansa ya m'mapapo yaying'ono siyoyenera 53. Khansa-yotuluka yaing'ono-cell neuroendocrine prostate khansa (t-SCNC)

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