Nnyocha / ebe / adakarị-ọnwụnwa / nctn

NCTN: NCI nke National Clinical Trials Network

Chọọ maka baajị a na nzukọ na otu ụlọ ọrụ na-esonye. Ọ pụtara na National Cancer Institute (NCI) enyela ha onyinye dịka onye otu NCI National Clinical Trials Network (NCTN).

NCI National Network Clinical Trials Network (NCTN) bụ nchịkọta nke ndị otu na ndị dibịa na-ahazi ma na-akwado ule gbasara ọrịa kansa n'ihe karịrị saịtị 2,200 gafee United States, Canada, na mba ụwa. NCTN na-enye akụrụngwa maka ọgwụgwọ NCI na-akwụ ụgwọ yana isi nyocha ihu onyonyo iji meziwanye ndụ ndị nwere ọrịa kansa.

Nlere ule NCTN na-enyere aka ịmepụta ụkpụrụ nlekọta ọhụrụ, setịpụrụ ọnọdụ maka nkwado nke ọgwụgwọ ọhụrụ site na Nchịkwa nri na ọgwụ ọjọọ, nwalee usoro ọgwụgwọ ọhụrụ, na ime ka ndị na-emepụta ọgwụ ọhụrụ nweta.

NCI amalitela ọtụtụ ule site na NCTN, gụnyere:

• ALCHEMIST: Adjuvant Lung Cancer Enrichment Marker Identification na Usoro Ọnwụnwa

• DART: Anti-CTLA-4 na Mgbochi Anti-PD-1 na Ọnwụ Tumo Tare

• Lung-MAP: Usoro nke II / III Biomarker-Draven Master Protocol maka usoro ọgwụgwọ nke abụọ maka ọkwa ọhụụ na-abụghị obere Cell

• NCI-MATCH: Molecular Analysis for Choice Choice maka ndị okenye nwere ọrịa cancer dị elu

• NCI-COG Pediatric MATCH: Nyocha Molecular maka Nhọrọ Agwọ maka ụmụaka na ndị na-eto eto nwere ọrịa cancer.

• NCI-NRG ALK Master Protocol: Usoro nyocha nke biomarker maka ọgwụgwọ nke ndị ọrịa NSCLC na-abụghị squamous

Otu Netwọk na Ndi Nkwado Ha

Usoro nhazi nke netwọkụ dị mma maka ịlele ọnụ ọgụgụ nke ndị ọrịa iji chọta ndị etuto ha na-egosipụta atụmatụ akwara na-enye ha ohere kachasị mma ịzaghachi ọgwụgwọ ọhụrụ ezubere iche. Maka ndị dọkịta na ndị ọrịa ha, menu nke nnwale dị mkpa dị n'ọtụtụ ebe na mba ahụ, na nnukwu obodo na obere obodo. NCTN na-enye ụzọ kachasị mma maka ọtụtụ ndị na-ahụkarị na, na-arịwanye elu, ọbụlagodi ọrịa cancer.

Nlekọta nke NCTN-nhazi ya, nhazi ya, na usoro nduzi ya ogologo oge-dị n'okpuru usoro nke Clinical Trials na Translational Committee Advisory Committee (CTAC). Kọmitii ndụmọdụ gọọmenti etiti a bụ nke ndị ọkachamara na-ahụ maka ọnwụnwa, ndị nnọchi anya ụlọ ọrụ, na ndị na-akwado ndị ọrịa si n'ofe mba ahụ wee nye ndị isi NCI ndụmọdụ.

Usoro NCTN gụnyere otu ndị otu US Network Network na Canadian Collaborating Clinical Trials Network. Ndị otu ndị otu NCTN dabere na njirisi akọwapụtara nke ọ bụla. Saịtị nwere ike ịbụ karịa otu otu, yana ịbụ ndị otu opekata mpe otu na-enye ohere ka saịtị tinye aka na ọnwụnwa nke otu NCTN na-eduzi nke ndị nyocha ha ruru eru. N'ihi ya, ndị na-eme nchọpụta sitere na LAPS, NCORP, ebe agụmakwụkwọ ndị ọzọ, omume obodo, na ndị otu mba ụwa jikọtara ndị otu Network nwere ike debanye aha ndị ọrịa n'ule NCTN. Ọnwụnwa ahụike nke ndị otu NCTN na-eduzi nwere ike ịnweta nkwado site na IROC Group, ITSAs, na ụlọ akụ anụ ahụ, dịka mkpa sayensị nke ọnwụnwa ahụ si dị.

Otu Netwọk

Ndi NCTN nwere ndi okenye ano na otu ndi otu ndi gbadoro anya na oria ndi umuaka. Ihe owuwu ahụ gụnyekwara Network Collaborating Clinical Trials Network. Ise US Network Groups bụ:

• Alliance maka Clinical Ọnwụnwa na OncologyExit Disclaimer

• ECOG-ACRIN Ọrịa Cancer Research

• NRG OncologyExit Nkwuputa

• SWOGExit Nkwuputa

• 'Smụaka Oncology Group (COG) Wepu Nkwupụta

A na-enye ndị otu US ego ọ bụla site na onyinye abụọ dị iche iche-otu iji kwado Ọrụ Ndị Ọrụ na nke ọzọ iji kwado Statlọ Ọrụ Statistics na Data Management. Opelọ Ọrụ Operations bụ ọrụ maka ịmepụta usoro iwu ọhụụ na ijikwa usoro iwu, ego, ndị otu na kọmitii sayensị nke otu ọ bụla. Thelọ Ọrụ Statistical bụ ọrụ maka njikwa data na nyocha, nkwadebe ederede, na nlekota nchekwa, na mgbakwunye inye aka na nhazi ikpe na mmepe.

Ndị otu Canadian Network Group na ndị US Network Groups na omume nke ndị ahọpụtara, ngwụsị oge, nnwale ọtụtụ ụlọ ọgwụ. Otu Canadian Network Group bu:

• Distù Na-ahụ Maka Ọrịa Cancer Canada (CCTG) Wepụ Nkwupụta

Opelọ Ọrụ Ntanetị na Statlọ Ọrụ Nkọwapụta nke otu NCTN dị iche iche ma ha na-arụkọ ọrụ ọnụ. Ha na-anọkarị na ụlọ akwụkwọ agụmakwụkwọ nke nyere ndị otu ụlọ "ụlọ"; agbanyeghị, n'ọtụtụ ọnọdụ, etiti dị na saịtị nnwere onwe na-akwụ ụgwọ site na ntọala enweghị ọrụ. Naanị nke a dị n'elu bụ Canadian Collaborating Clinical Trials Network, nke natara otu onyinye maka Operations na Statistical Center.

Na-eduga saịtị na-ekere òkè na agụmakwụkwọ (LAPS)

Enyerela ụlọ ọrụ agụmakwụkwọ iri atọ na abụọ na US onyinye agụmakwụkwọ na-eduga na saịtị (LAPS), nke bụ isi iyi nke ego etolitere maka NCTN. Saịtị ndị a bụ ụlọ ọrụ nyocha agụmakwụkwọ yana mmemme ọzụzụ mmekọrịta, yana ọtụtụ n'ime ndị a na-atụ ụjọ bụ NCI-Achọpụtara Canlọ Ọrụ Ọrịa Cancer. Iji nweta onyinye ndị a, saịtị ga-egosipụta ikike ha nwere idebanye ọnụ ọgụgụ dị elu nke ndị ọrịa na ule NCTN, yana ndị ọkà mmụta sayensị na nhazi na omume nke ọnwụnwa ahụike.

Ihe 32 LAPS nyere bụ:

Westernlọ ọrụ Western Reserve University - Case Comprehensive Cancer Center Dana Farber / Harvard Cancer Center

Duke Institute nke Cancer na Duke University Medical Center

Mahadum Emory - Winship Cancer Institute

Fred Hutchinson Cancer Research .lọ Ọrụ

Mahadum Johns Hopkins - Sidney Kimmel Comprehensive Cancer Center

Yolọ Ọrịa Cancer Mayo

Mahadum Ahụike nke Wisconsin

Ememe Ncheta Sloan Kettering Cancer Center

Norris Cotton Cancer Center na Dartmouth Hitchcock Ahụike Ọgwụ

Mahadum Northwest - Robert H. Lurie Center Cancer Center

Ohio State University Comprehensive Ọrịa Cancer Center

Welllọ Ọrịa Cancer Roswell Park

Sidney Kimmel Cancer Center na Jefferson Ahụike

Mahadum Alabama na Birmingham

Mahadum California Davis Comprehensive Cancer Center

Mahadum Chicago Comprehensive Cancer Center

Mahadum nke Colorado Cancer Center

Mahadum nke Michigan Cancer Center

Mahadum nke North Carolina Lineberger Comprehensive Cancer Center

Mahadum Oklahoma - Stephenson Cancer Center

Mahadum nke Pittsburgh Cancer Institute

Mahadum nke Rochester Wilmot Cancer Institute

Mahadum nke Southern California - Norris Comprehensive Cancer Center

Mahadum Texas MD Anderson Cancer Center

Mahadum nke Texas Southwest Medical Center - Harold C. Simmons Cancer Center

Mahadum Utah - Huntsman Cancer Institute

Mahadum Wisconsin Carbone Cancer Center

Vanderbilt University Medical Center - Vanderbilt Ingram Ọrịa Cancer Center

Mahadum Washington na St. Louis - Siteman Cancer Center

Mahadum Wayne State Barbara Ann Karmanos Institute Institute of Cancer

Mahadum Yale - Yale Cancer Center

Ọkwa dị elu nke ntinye aha onye ọrịa chọrọ ka a na-akwado ọrụ njikwa data ruo ọtụtụ afọ, na LAPS na-akwado ndị ọrụ nyocha achọrọ iji jikwaa mbọ a. Ego enyere na LAPS nyere iji kpuchie ọrụ a bara ụba na-ebuli ọkwa nkwụghachi ụgwọ nke onye ọ bụla na saịtị ndị ahọpụtara.

Onyinye LAPS na-enyekwa ego maka ndị ọkà mmụta sayensị na ndị isi nchịkwa na saịtị ahụ n'onwe ya, dịka ndị isi nyocha na saịtị ahụ kwesịrị ibute ọnwụnwa ahụike ha na-ekere òkè na ya, yana ịkụziri ma zụọ ndị ọrụ na saịtị ahụ na nyocha ahụike na ịzụlite. atụmatụ iji kwalite idebanye aha ndị ọrịa.

Hosplọọgwụ Obodo na Medicallọ Ọrụ Ahụike

Ọtụtụ ndị nchọpụta ndị ọzọ na ụlọ ọgwụ obodo na ebe ahụike nwere ike isonye na nnwale NCTN, ọbụlagodi na ha nọ na saịtị ndị na-anataghị onyinye LAPS. Saịtị ndị a, yana ọtụtụ saịtị mba ofesi, na-anata ụgwọ nkwụghachi ụgwọ nyocha sitere n'aka otu n'ime netwọkụ ndị ha na ha jikọrọ ma ọ bụ na ha na-enweta onyinye site na NCI Community Oncology Research Programme (NCORP).

Ndị otu nọ na otu NCTN dabere na njirisi akọwapụtara nke ọ bụla. Ebe ndị na-eduzi ule ahụike nwere ike ịbụ ihe karịrị otu, na ịbụ ndị otu ọ dịkarịa ala otu na-enye ohere saịtị ịbanye na ọnwụnwa nke otu NCTN na-eduzi nke ndị nyocha ha ruru eru. N'ihi ya, ndị na-eme nchọpụta sitere na LAPS, NCORP, ebe agụmakwụkwọ ndị ọzọ, omume obodo, na ndị otu mba ụwa jikọtara ndị otu Network nwere ike debanye aha ndị ọrịa n'ime ọnwụnwa NCTN.

Oncology Core Group (IROC) na Onyonyo na Radiation.

Iji nyere aka nyochaa ma hụ na ịdị mma na ọnwụnwa metụtara usoro onyonyo ọhụụ na / ma ọ bụ ọgwụgwọ radieshon, NCTN guzobere Imaging na Radiation Oncology Core (IROC) GroupExit Disclaimer nke na-enyere ndị otu NCTN niile aka na-eji usoro ndị a na ule ha.

Mmụta Onyinye Ntụgharị Asụsụ (ITSA)

Akụkụ ikpeazụ nke NCTN bụ Integrated Translational Science Awards (ITSAs). Ulo akwukwo ulo akwukwo ise ndi natara ITSA gunyere otutu ndi okacha amara nke ntughari okwu nke na eji usoro ihe omumu ohuru, ihe nchebe, na teknụzụ imaging iji nyere aka imata ma tozuo ndi na-achoputa ihe banyere ndi mmadu banyere nzaghachi nke ndi otu ntaneti nwere ike itinye n'ime ule ndi ozo.

A na-eji onyinye ndị a eme ihe iji rụpụta ọrụ amalitelarị na ụlọ nyocha nke ndị ọrụ nyocha a, nke ndị enyemaka NCI ndị ọzọ na-akwadokarị, na-atụ anya na ndị nchọpụta a ga-enyere ndị otu netwọkụ aka iweta nchọpụta ụlọ nyocha ọhụụ n'ime ule ahụike. Ndị ụlọ ọrụ ndị a niile na-eji teknụzụ na-enweghị atụ nke na-eme ka njirimara etuto dị mma karịa ma nyere aka chọpụta mgbanwe dị iche iche nke usoro ọgwụgwọ na ọgwụgwọ nke nwere ike inye aka kọwaa etu nguzogide ọgwụgwọ si amalite.

Onyinye ITSA bu:

Hospitallọ Ọgwụ Childrenmụaka nke Philadelphia

Mahadum Emory - Winship Cancer Institute

Ememe Ncheta Sloan Kettering Cancer Center

Ohio State University Comprehensive Cancer Center - Ọpụpụ Disclaimer

Mahadum North Carolina Lineberger Comprehensive Cancer CenterExit Disclaimer

NCTN anụ ahụ Banks

Otu NCTN ọ bụla na-anakọta ma na-echekwa anụ ahụ n'aka ndị ọrịa nọ na ule NCTN na netwọkụ jikọtara ọnụ nke akụ anụ ahụ. E mepụtara usoro ogbugba ndu iji hụ na anụ ahụ anakọtara kacha mma. Ihe ndekọ ederede kọmputa nke ihe nchekwa echekwara nwere nkọwa ahụike dị mkpa, dị ka ọgwụgwọ ndị ọrịa natara site na ndị e wepụrụ anụ ahụ, nzaghachi ọgwụgwọ, na npụta onye ọrịa. Ndị sonyere na ule NCTN nwekwara ike kwenye na iji ụdị anụ ahụ ha maka ọmụmụ ihe karịa ule NCTN nke edebara aha ha. Ihe omume NCTN anụ ahụ na-agụnye usoro ntanetị weebụ nke onye nyocha ọ bụla nwere ike iji. Ndị nchọpụta, gụnyere ndị na-esoghị na NCTN,

Kọmitii na-ahụ maka nlekọta sayensị

Ndị otu NCTN na-atụ aro echiche maka ule ọhụụ ọhụụ na Kọmitii Na-ahụ Maka Ọrịa NCI / Imaging NCI. Ndị NCI na-ahazi kọmitii ndị a iji nyochaa ma na-ebute ụzọ ọhụụ ọhụụ na-akwado NCI ndị nwere ike ịnwe mmetụta sayensị na ahụike kachasị elu. Ndị otu kọmitii na-abụghị ndị gọọmentị na-eduzi kọmitii ọ bụla na-enyeghị ikike ijide ọnọdụ ndị isi na ndị otu NCTN, n'agbanyeghị na ha nwere ike ịbụ ndị otu. Ndị ọzọ so na kọmitii ahụ nwere ndị otu NCTN ndị otu ọ bụla họpụtara, ndị ọkachamara n'ọrịa ndị ọzọ anaghị etinye aka n'ọkwa ndị isi, ndị nnọchi anya NCI a kwụrụ ụgwọ na SPORE na Consortia, ndị biostatisticians, ndị ọrịa na-akwado, na ndị ọkachamara na ọrịa NCI.

NCTN mmefu ego

Ego NCTN zuru ezu bụ $ 171 nde, kesara akụkụ dị iche iche nke netwọk ahụ. Usoro a na-enye aha ndebanye aha kwa afọ banyere ndị 17,000-20,000 na ọgwụgwọ kansa na ọnwụnwa ima ihe.

Rụ ọrụ na Njikọ Aka

Otu NCTN nwere ike belata ọnụahịa nke ịme ule site na ịkekọrịta ihe onwunwe. Usoro mmekọrịta a na-enye ndị otu NCTN ohere iji kwado ọnwụnwa ndị otu ndị ọzọ na-eduzi ma na-enye ndị otu NCTN ikike ịmepụta akwụkwọ mpịakọta nke ule na ọrịa cancer kachasị.

N'ihi na NCTN nwere naanị otu ndị okenye US anọ, nwere obere Ọrụ na Statistical Centers na-achọ nkwado ego, enweela ego nkwụnye ego. Ndị otu a niile na-eji usoro njikwa data jikọtara ọnụ (Medidata Rave) na sistemụ IT jikọtara ọnụ maka ụlọ anụ ahụ, nke sụgharịrị ịbụ ego echekwara.

Mgbakwunye Nkwado

Ọnwụnwa ahụike bụ ọrụ dị mgbagwoju anya nke chọrọ ọtụtụ ụlọ ọrụ nkwado na iyi ego. Netwọk ahụ gụnyere ọtụtụ atụmatụ ndị ọzọ na-esonyeghị na onyinye NCTN mana nke ahụ dị mkpa iji rụọ ọrụ NCTN.

Nkwado ndị ọzọ gụnyere:

• Central Institutional Review Boards, ihe dị mkpa nke usoro nyocha nke ụlọ ọgwụ NCI na-agbakwunye ọsọ, arụmọrụ, na ịdị n'otu na nyocha nke ụkpụrụ omume.

• Supportlọ Ọrụ Nkwado Ọrịa Cancer (CTSU), nkwekọrịta NCI na-akwụ ụgwọ nke na-enye ndị nchọpụta nyocha na ndị ọrụ ha otu nkwụsị na ntanetị iji nweta ule NCTN ma nye ndị nyocha ohere ịdebanye ndị ọrịa ọhụrụ.

• Tissuelọ akụ anụ ahụ raara onwe ha nye maka otu Network Network kwụrụ ụgwọ site na iche usoro NCI.

• Biomarker, Imaging, na Quality of Life Studies Funding Program (BIQSFP), ego dị iche iche maka ule NCTN na-akwado ọmụmụ sayensị metụtara na ule otu. Ndị otu NCTN na-asọ mpi maka ego edebere kwa afọ maka ebumnuche a. Inwe ego a raara nye na-eme ka nchikota aka, n'ihi na ule ogwu agha aghaghi imechi usoro ihe siri ike.

• Tụkwasị na nke ahụ, ihe dị ka otu ụzọ n'ụzọ anọ nke nhụjuanya nke ọrịa ndị NCTN na-akwụ ụgwọ site na mmemme NCORP. A na-akwụghachi ụlọ ọgwụ obodo na ụlọ ọrụ ahụike na-esonye na mmemme NCORP maka ị nweta ndị ọrịa na nnwale ọgwụgwọ NCTN site na nrite NCORP ha, ọ bụghị site na ntanye Ọrụ Ndị Ọrụ NCTN.

N'ikpeazụ, na mgbakwunye na mmefu ego ndị a kwa afọ, NCI na-akwado NCTN site na ịkwụ ụgwọ maka ọtụtụ ọrụ ikpe ikpe ndị ọzọ dị mkpa, si otú a na-ebelata ụgwọ ndị otu netwọkụ na-akwụ:

• NCI na-akwụ ụgwọ maka ikikere na ụgwọ nnabata nke igwe elektrọnik, sistemụ njikwa data nkịtị, nke akpọrọ Medidata Rave, nke ndị otu NCTN niile na-eji.

• NCI na-elekọta usoro nyocha nke mba maka ule NCTN.

• NCI na-ejikwa ngwa ọgwụ ọgwụ nyocha ọhụrụ na Nchịkwa nri na ọgwụ ọjọọ yana nkesa ọgwụ ndị a maka ọtụtụ ule NCTN.

A na-ele mmekorita n'etiti otu dị ka ihe dị mkpa maka ịga nke ọma na ọkwa niile ma na-akwụghachi ụgwọ ugbu a n'oge nyocha enyemaka. A na-ekwusi ike na arụmọrụ, usoro iheomume dị mkpa dịkwa maka mmepe protocol. Ọ bụ ezie na a na-ele mgbanwe ndị a anya dị ka ihe dị mkpa maka ahụike nke usoro ọha na eze, ha na-abịa n'oge dị mma, n'ihi na mgbanwe na-akpali akpali na sayensị oncologic na-enye ụzọ ọhụrụ maka ọganihu ngwa ngwa, ọkachasị maka mmepe nke usoro ọgwụgwọ ọhụụ.