Hom / lymphoma / tus neeg mob / mycosis-fungoides-kev kho mob-pdq

Kev Kho Mob Mycosis Fungoides (Nrog Rau Sézary Syndrome) Kev Kho Mob (®) –Patient Version

Cov Lus Qhia Txog Hais Txog Tus Mob Mycosis Fungoides (suav nrog Tus Mob Sézary)

QHOV TSEEM CEEB

• Mycosis fungoides thiab Sézary syndrome yog cov kab mob uas cov lymphocytes (ib hom qe ntshav dawb) dhau los ua neeg muaj mob (ua rau mob cancer) thiab cuam tshuam rau daim tawv nqaij.

• Cov mob hu ua Mycosis fungoides thiab Sézary syndrome yog yam uas yuav txiav qhov mob T-cell lymphoma.

• Qhov cim ntawm mycosis fungoides yog pob liab liab rau ntawm daim tawv nqaij.

• Hauv cov kab mob Sézary, muaj cov keeb-T mob cancer nyob hauv cov ntshav.

• Kev kuaj mob uas kuaj cov tawv nqaij thiab ntshav tau siv los kuaj xyuas mycosis fungoides thiab Sézary syndrome.

• Qee yam cuam tshuam txog kev raug (mob rov qab) thiab txoj kev kho.

Mycosis fungoides thiab Sézary syndrome yog cov kab mob uas cov lymphocytes (ib hom qe ntshav dawb) dhau los ua neeg muaj mob (ua rau mob cancer) thiab cuam tshuam rau daim tawv nqaij.

Feem ntau, cov hlwb pob txha ua rau cov qe ntshav (cov hlwb tsis paub qab hau) uas ua cov qe ntshav muaj hlwb thaum lub sijhawm dhau los. Cov qe ntshav ntshav yuav dhau los ua myeloid qia cell los yog lymphoid qia cell. Myeloid qia cell dhau los ua cov qe ntshav liab, ntshav dawb, lossis cov ntshav tawm ntshav. Lymphoid qia cell dhau los ua lymphoblast thiab tom qab ntawd ib qho ntawm peb hom lymphocytes (cov qe ntshav dawb):

• B-cell lymphocytes uas ua rau cov tshuaj tiv thaiv kev tua kab mob.

• T-cell lymphocytes uas pab B-lymphocytes ua rau cov tshuaj tiv thaiv uas pab tua kab mob sib kis.

• Tus kab mob tua neeg uas tua cov qog noj ntshav thiab kab mob.

Kev loj hlob ntawm cov ntshav. Cov qe ntshav muaj hla ntau kauj ruam dhau los ua lub qe ntshav liab, ntshav tawm, lossis qe ntshav dawb.

Hauv mycosis fungoides, T-cell lymphocytes ua rau mob qog thiab cuam tshuam rau daim tawv nqaij. Thaum cov lymphocytes no tshwm sim hauv cov ntshav, lawv tau hu ua Sézary cell. Hauv cov kab mob Sézary, mob cancer T-cell lymphocytes cuam tshuam rau daim tawv nqaij thiab ntau ntawm Sézary cov hlwb muaj nyob hauv cov ntshav.

Cov mob hu ua Mycosis fungoides thiab Sézary syndrome yog yam uas yuav txiav qhov mob T-cell lymphoma.

Mycosis fungoides thiab Sézary syndrome yog ob hom mob uas feem ntau ntawm txoj kev txiav tawm T-cell lymphoma (hom mob uas tsis yog Hodgkin lymphoma). Yog xav paub txog lwm hom mob qog nqaij hlav tawv nqaij lossis tsis yog Hodgkin lymphoma, saib cov lus hauv qab no :

• Cov Neeg Loj Tsis-Hodgkin Lymphoma Kev Kho Mob

• Kev Kho Mob Cancer

• Melanoma Kev Kho Mob

• Kaposi Sarcoma Kev Kho Mob

Qhov cim ntawm mycosis fungoides yog pob liab liab rau ntawm daim tawv nqaij.

Mycosis fungoides tuaj yeem mus rau hauv cov theem hauv qab no:

• Premycotic theem: Txiab ua pob liab liab nyob rau thaj chaw ntawm lub cev uas feem ntau tsis nphav tshav. Cov pob xoo no tsis ua kev tshwm sim thiab yuav nyob ntev rau lub hlis lossis xyoo. Nws yog ib qho nyuaj rau kuaj cov pob khaus raws li mycosis fungoides nyob rau theem no.

• Thaj theem: Txawv liab, liab ploog, zoo li pob khaus liab.

• Quav Qeb: Cov pob txha me me ua pob (papules) lossis tawv tawv txhab rau ntawm daim tawv nqaij, uas tej zaum yuav ua liab ploog.

• Tumor theem: Cov nqaij hlav ua rau ntawm daim tawv nqaij. Cov hlav no yuav pib ua mob ua paug thiab daim tawv nqaij yuav kis tau tus mob.

Nrog koj tus kws kho mob tham yog tias koj muaj cov cim no.

Hauv cov kab mob Sézary, muaj cov keeb-T mob cancer nyob hauv cov ntshav.

Tsis tas li, daim tawv nqaij thoob plaws lub cev yog liab ploog, khaus, tev thiab mob. Tej zaum tseem yuav muaj qhov ua kom thaj, quav hniav, lossis qog cov tawv nqaij. Nws tseem tsis tau paub yog Sézary syndrome yog hom kab mob siab rau mycosis fungoides lossis ib tus kab mob cais.

Kev kuaj mob uas kuaj cov tawv nqaij thiab ntshav tau siv los kuaj xyuas mycosis fungoides thiab Sézary syndrome.

Cov ntawv xeem thiab txheej txheem hauv qab no yuav raug siv:

• Kev kuaj mob lub cev thiab keeb kwm kev noj qab haus huv: Kev kuaj lub cev kom kuaj xyuas cov cim ntawm kev noj qab haus huv, suav nrog kuaj kab mob ntawm tus kab mob, xws li mob qog, tus lej thiab hom mob ntawm daim tawv nqaij, lossis lwm yam uas zoo li txawv txawv. Cov duab ntawm daim tawv nqaij thiab keeb kwm ntawm tus neeg mob txoj kev noj qab haus huv * kev coj ua thiab kev mob nkeeg yav dhau los thiab kev kho yuav tseem yuav coj los.

• Ua kom tiav cov ntshav suav nrog qhov sib txawv: Tus txheej txheem uas coj cov ntshav mus kuaj thiab kuaj rau cov hauv qab no:

• Tus lej ntawm cov ntshav liab thiab cov qe ntshav.

• Tus lej thiab hom ntshav dawb.

• Cov ntshav hemoglobin (cov protein uas nqa oxygen) hauv cov ntshav liab.

• Feem ntawm cov ntshav ua tau los ntawm cov ntshav liab.

Ua kom tiav cov ntshav suav (CBC). Ntshav yog sau los ntawm kev ntxig ib rab koob rau hauv cov leeg thiab pub cov ntshav tuaj rau hauv lub raj. Cov ntshav ntsuas raug xa mus rau chav kuaj thiab ntshav liab, ntshav dawb, thiab cov ntshav khov yog suav. Lub CBC yog siv los ntsuas rau, ntsuas mob, thiab saib xyuas ntau yam mob.

• Sézary cell cell suav: Tus txheej txheem uas coj cov ntshav mus kuaj hauv lub tshuab tsom kab mob kom suav cov qe Sézary.

• Kev kuaj HIV: Kev ntsuas ntsuas los ntsuas theem ntawm cov tshuaj tiv thaiv HIV rau hauv tus qauv ntsuas ntshav. Cov tshuaj tua kab mob yog tsim los ntawm lub cev thaum nws txeeb los ntawm cov tshuaj txawv teb chaws. Theem tiv thaiv cov kab mob HIV ntau dua tej zaum txhais tau tias lub cev muaj tus kabmob HIV.

• Daim tawv nqaij sawv nqaij: tshem tawm cov nqaij los yog nqaij kom lawv tuaj yeem saib nyob rau hauv lub tshuab tsom kab ntsig kom kuaj pom tus cim mob qog nqaij hlav. Tus kws kho mob yuav tshem tawm kev loj hlob ntawm daim tawv nqaij, uas yuav mus tshuaj xyuas tus kws khomob. Yuav tsum muaj ntau tshaj ib qho kev txhab nqaij ntawm daim tawv nqaij txhawm rau kuaj mob mycosis fungoides. Lwm yam kev ntsuam xyuas uas tuaj yeem ua rau hauv lub hlwb lossis cov qauv ntawm lub ntswg yog suav cov hauv qab no:

• Immunophenotyping: Kev sim tshuaj uas siv tshuaj tiv thaiv kab mob ntawm cov qog nqaij hlav cancer ua raws li hom antigens lossis cim rau ntawm cov kem hlwb. Qhov kev ntsuam xyuas no yog siv los pab txheeb xyuas qee hom qog ntshav.

• Flow cytometry: Kev sim ntsuas uas ntsuas cov naj npawb ntawm cov cell hauv ib qho piv txwv, qhov feem pua ​​ntawm cov nyob hauv ib qho piv txwv, thiab qee cov yam ntxwv ntawm lub hlwb, xws li qhov loj me, cov duab, thiab muaj cov qog (lossis lwm yam) cov cim rau ntawm ntawm tes nto. Cov qog los ntawm cov qauv ntawm tus neeg mob cov ntshav, pob txha pob txha, lossis lwm cov nqaij yog nyob nrog cov xim fluorescent, tso rau hauv dej, thiab tom qab ntawd kis ib tus dhau ib ntus los ntawm lub teeb. Cov kev sim coj los txiav txim siab raws li yuav ua li cas cov qog hlwb uas tsuas nrog cov xim fluorescent hnov ​​mob rau lub nqaj ntawm lub teeb. Qhov kev kuaj ntshav no yog siv los pab txheeb xyuas thiab tswj hwm qee yam qog nqaij hlav, xws li mob qog ntshav thiab mob qog.

• Kev kuaj mob T-cell (TCR): Kev kuaj ntshav kuaj cov qe ntshav hauv tus hlwb lossis rau cov hlwb pob txha los soj ntsuam seb puas muaj qee yam pauv hloov cov gene uas ua rau cov receptors ntawm T cell (ntshav dawb). Kev kuaj cov noob hloov pauv tuaj yeem qhia paub seb muaj pes tsawg tus ntawm T cell nrog qee T-cell receptor tab tom ua.

Qee yam cuam tshuam txog kev raug (mob rov qab) thiab txoj kev kho.

Qhov raug thiab kho kev xaiv nyob ntawm cov hauv qab no:

• Theem mob cancer.

• Hom mob txhab (plooj, plaques, lossis hlav).

• Tus neeg mob lub hnub nyoog thiab poj niam txiv neej.

Mycosis fungoides thiab Sézary syndrome yeej nyuaj kho. Kev kho mob feem ntau yog palliative, txhawm rau txo cov tsos mob thiab txhim kho lub neej zoo. Cov neeg mob uas yog mob rau thaum ntxov mas yuav nyob ntev ntau xyoo.

Theem ntawm Mycosis Fungoides (Nrog rau Sézary Syndrome)

QHOV TSEEM CEEB

• Tom qab kuaj mob mycosis fungoides thiab Sézary syndrome tau kuaj pom, kev txheeb xyuas tau ua tiav seb puas muaj cov qog mob cancer kis ntawm daim tawv mus rau lwm qhov ntawm lub cev.

• Muaj peb txoj hauv kev uas mob cancer kis hauv lub cev.

• Mob khees xaws yuav kis tau los ntawm qhov nws pib rau lwm qhov ntawm lub cev.

• Cov theem hauv qab no yog siv rau mycosis fungoides thiab Sézary syndrome:

• Theem Kuv Mycosis Fungoides

• Theem II Mycosis Fungoides

• Theem III Mycosis Fungoides

• Theem IV Mycosis Cov Mob Fungoides / Sézary Syndrome

Tom qab kuaj mob mycosis fungoides thiab Sézary syndrome tau kuaj pom, kev txheeb xyuas tau ua tiav seb puas muaj cov qog mob cancer kis ntawm daim tawv mus rau lwm qhov ntawm lub cev.

Cov txheej txheem tau siv los xyuas seb tus mob cancer tau kis los ntawm daim tawv nqaij mus rau lwm qhov hauv lub cev hu ua staging. Cov ntaub ntawv sau los ntawm cov txheej txheem theem txiav txim theem ntawm tus kab mob. Nws yog ib qho tseem ceeb uas yuav tsum paub txog theem kom thiaj li npaj tau kev kho mob.

Cov txheej txheem hauv qab no tuaj yeem siv rau hauv cov txheej txheem staging:

• Xoo Xaim: Xoos hluav taws xob ntawm cov plab hnyuv siab raum thiab pob txha hauv hauv siab. Qhov xoo hluav taws xob yog ib hom kev tawm dag zog ntawm lub zog uas tuaj yeem nkag mus hauv lub cev thiab mus rau zaj duab xis, ua duab ntawm thaj chaw hauv lub cev.

• CT scan (CAT scan): Cov txheej txheem uas ua rau cov duab ntxaws ntxaws ntawm cov chaw hauv lub cev, xws li lub qog ntshav, lub hauv siab, lub plab, thiab lub duav, coj los ntawm ntau cov ces kaum. Cov duab no yog tsim los ntawm lub koos pis tawj txuas nrog lub tshuab xoo hluav taws xob. Ib qho zas xim tuaj yeem raug txhaj rau hauv txoj hlab ntshav lossis nqos los pab rau cov kabmob lossis cov nqaij ua kom pom tseeb dua. Cov txheej txheem no tseem hu ua suav tomography, computer tom tomography, lossis computerized axial tomography.

• PET scan (positron emission tomography scan): Tus txheej txheem los nrhiav cov qog ua qog ntshav hauv lub cev. Ib qho me me ntawm cov kua hluav taws xob cov kua qab zib (qab zib) tau txhaj rau txoj hlab ntshav. PET scanner tig ncig lub cev thiab ua ib daim duab ntawm qhov chaw nyob hauv qab ntawm lub cev tau siv. Malignant qog hlwb nthuav qhia lub ci nyob hauv daim duab vim tias lawv nquag tshaj thiab noj ntau dua cov piam thaj dua li cov hlwb ua.

• Lymph node biopsy: Qhov tshem tawm tag nrho lossis ib feem ntawm cov qog ntshav. Tus kws kho mob tawm tswv yim saib cov qog ntshav ntawm lub qog tsom hauv lub tshuab kuaj kab mob.

• Mob pob txha rau txoj kev cia siab thiab kuaj me me: Tshem tawm cov pob txha pob txha thiab ib qho me me ntawm pob txha los ntawm ntxig rab koob hollow rau hauv lub duav lossis ob lub mis. Tus kws kho mob hais txog pob txha caj qaum thiab pob txha nyob hauv lub tshuab tsom seb puas pom cov cim mob qog nqaij hlav.

Muaj peb txoj hauv kev uas mob cancer kis hauv lub cev.

Kab mob khees xaws tuaj yeem kis tawm los ntawm cov nqaij mos, cov qog ntshav, thiab ntshav:

• Ntaub so ntswg. Tus kab mob cancer kis los ntawm qhov chaw nws pib kis los ntawm thaj chaw ze.

• Lymph system. Tus mob cancer kis ntawm qhov uas nws pib los ntawm kev nkag rau hauv lymph system. Tus kab mob cancer taug kev los ntawm cov qog ntshav mus rau lwm qhov ntawm lub cev.

• Ntshav. Tus mob cancer kis rau nws los ntawm qhov nws pib los ntawm nkag rau hauv cov ntshav. Tus kabmob khiav tawm hauv cov hlab ntshav mus rau lwm qhov ntawm lub cev.

Mob khees xaws yuav kis tau los ntawm qhov nws pib rau lwm qhov ntawm lub cev.

Thaum mob cancer kis mus rau lwm qhov hauv lub cev, nws hu ua metastasis. Kab mob khees xaws khiav tawm ntawm qhov chaw lawv pib (thawj qog) thiab taug kev hauv cov qog ntshav lossis ntshav.

Lymph system. Cov qog nqaij hlav nkag mus rau hauv lub lymph system, taug kev hauv cov hlab ntsws, thiab ua cov qog ntshav (metastatic hlav) hauv lwm qhov ntawm lub cev.

Ntshav. Cov qog ntshav nkag mus rau hauv cov ntshav, taug kev los ntawm cov hlab ntshav, thiab tsim cov qog ntshav (metastatic hlav) hauv lwm qhov chaw ntawm lub cev. Cov mob metastatic yog tib yam kabmob uas yog thawj cov qog. Piv txwv li, yog tias mycosis fungoides kis mus rau lub siab, cov qog nqaij hlav cancer hauv lub siab yog qhov mycosis fungoides hlwb. Tus mob yog metastatic mycosis fungoides, tsis yog mob cancer rau daim siab.

Cov theem hauv qab no yog siv rau mycosis fungoides thiab Sézary syndrome:

Theem Kuv Mycosis Fungoides

Theem Kuv tau muab faib ua ntu IA thiab IB raws li hauv qab no:

• Theem IA: Thaj ua rau thaj, papules, thiab / lossis cov ntaub qhwv ua npog tsawg dua 10% ntawm daim tawv nqaij.

• Theem IB: Thaj ua rau thaj, papules, thiab / lossis cov ntaub qhwv ua npog 10% lossis ntau dua ntawm daim tawv nqaij.

• Tej zaum yuav muaj cov qe Sézary tsawg nyob hauv cov ntshav.

Theem II Mycosis Fungoides

Ntu II tau faib rau theem IIA thiab IIB raws li hauv qab no:

• Theem IIA: Thaj ua rau thaj, papules, thiab / lossis cov ntaub ntawv npog yuav tsum npog ib qho ntawm daim tawv nqaij. Cov qog ntshav ua haujlwm txawv, tab sis lawv tsis mob qog noj ntshav.

• Theem IIB: Ib lossis ntau dua cov qog uas ntev li 1 centimeter lossis loj dua yog pom ntawm daim tawv nqaij. Cov qog ua ntshav yuav txawv txav, tab sis lawv tsis mob qog.

Tej zaum yuav muaj cov qe Sézary tsawg nyob hauv cov ntshav.

Theem III Mycosis Fungoides

Hauv theem III, 80% lossis ntau dua ntawm daim tawv nqaij yog rov ua dua thiab tuaj yeem muaj thaj ua rau thaj, papules, plaques, lossis hlav hlav. Cov qog ua ntshav yuav txawv txav, tab sis lawv tsis mob qog.

Tej zaum yuav muaj cov qe Sézary tsawg nyob hauv cov ntshav.

Theem IV Mycosis Cov Mob Fungoides / Sézary Syndrome

Thaum muaj ntau ntau ntawm cov Sézary hlwb hauv cov ntshav, tus kab mob hu ua Sézary syndrome.

Theem IV tau muab faib ua theem IVA1, IVA2, thiab IVB raws li hauv qab no:

• Theem IVA1: Thaj ua rau thaj, papules, plaques, lossis qog yuav npog tau ntau npaum li cas ntawm daim tawv nqaij, thiab 80% lossis ntau dua ntawm daim tawv nqaij yuav rov ua dua. Cov qog ntshav ua haujlwm yuav txawv txav, tab sis lawv tsis mob qog. Muaj ntau ntau lub qe Sézary nyob rau hauv cov ntshav.

• Theem IVA2: Thaj ua rau thaj, papules, plaques, lossis qog yuav npog tau ntau npaum li cas ntawm daim tawv nqaij, thiab 80% lossis ntau dua ntawm daim tawv nqaij yuav rov ua dua. Cov qog ua kua muaj qhov txawv txav heev, los yog mob qog nqaij hlav tau ua rau cov qog ntshav hauv lub qog. Tej zaum yuav muaj ntau cov Sézary hlwb nyob rau hauv cov ntshav.

• Theem IVB: Kab mob cancer tau kis rau lwm yam hauv lub cev, xws li tus po los yog mob siab. Thaj ua rau thaj, papules, plaques, lossis cov qog yuav npog qhov nyiaj ntawm daim tawv nqaij, thiab 80% lossis ntau dua ntawm daim tawv nqaij yuav rov ua dua. Cov qog ntshav hauv plab yuav yog qhov txawv lossis mob qog nqaij hlav. Tej zaum yuav muaj ntau cov Sézary hlwb nyob rau hauv cov ntshav.

Txoj Kev Kho Mob Cov Tswv Yim

QHOV TSEEM CEEB

• Muaj ntau hom kev kho mob rau cov neeg mob mycosis fungoides thiab Sézary syndrome mob cancer.

• Xya hom qauv kev kho mob tau siv:

• Photodynamic txoj kev kho

• Kev siv hluav taws xob

• Kws khomob

• Lwm txoj kev kho tshuaj

• Kev Txhaj Tshuaj Tiv Thaiv

• Cov hom phiaj kho

• Kev siv tshuaj kho mob ntau dua thiab kev kho hluav taws xob nrog kev hloov pauv ntawm qia

• Cov hom kev kho mob tshiab tau raug sim hauv qhov kev sim kho mob.

• Kev kho rau mycosis fungoides thiab Sézary syndrome yuav ua rau muaj kev phiv.

• Cov neeg mob yuav xav txog kev sim kho mob.

• Cov neeg mob tuaj yeem nkag mus kuaj mob ua ntej, sijhawm, lossis tom qab pib kho mob qog noj ntshav.

• Tej zaum yuav tau ua raws li kev ntsuam xyuas.

Muaj ntau hom kev kho mob rau cov neeg mob mycosis fungoides thiab Sézary syndrome mob cancer.

Kev kho mob sib txawv muaj rau cov neeg mob mycosis fungoides thiab Sézary syndrome. Qee qhov kev kho mob yog tus qauv (cov kev kho mob tam sim no), thiab qee qhov raug sim hauv kev kuaj mob. Ib txoj kev kho mob hauv tsev kho mob yog txoj kev tshawb nrhiav uas pab txhawm rau txhim kho kev kho mob tam sim no lossis tau txais cov ntaub ntawv ntawm kev kho mob tshiab rau cov neeg mob cancer. Thaum kuaj pom tias cov kev kho tshiab zoo dua li kev kho mob, cov kev kho mob tshiab tuaj yeem dhau los ua cov qauv kev kho mob. Cov neeg mob yuav xav txog kev sim kho mob. Qee qhov kev sim tshuaj sim tsuas yog qhib rau cov neeg mob uas tsis tau pib kho.

Xya hom qauv kev kho mob tau siv:

Photodynamic txoj kev kho

Photodynamic therapy yog kev kho mob qog nqaij hlav uas siv tshuaj thiab qee hom teeb ci los tua cov qog noj ntshav. Cov tshuaj uas tsis ua haujlwm kom txog thaum nws raug rau lub teeb raug txhaj rau hauv txoj hlab ntshav. Cov tshuaj sau ntau nyob rau hauv cov kabmob kheesxaws dua li ntawm cov cell ib txwm muaj. Rau kev mob qog nqaij hlav, laser lub teeb ci ntsa rau ntawm daim tawv nqaij thiab cov tshuaj ua kom nquag plias thiab tua cov qog nqaij hlav cancer. Photodynamic txoj kev kho ua rau kev puas tsuaj me me rau cov nqaij mos noj qab haus huv. Cov neeg mob uas kho cov duab thaij duab yuav tsum txwv cov sijhawm uas siv hauv tshav ntuj. Muaj ntau ntau hom kev kho mob photodynamic:

• Hauv kev psoralen thiab ultraviolet A (PUVA) txoj kev kho, tus neeg mob tau txais tshuaj hu ua psoralen thiab tom qab ntawd ultraviolet A hluav taws xob tau qhia rau ntawm daim tawv nqaij.

• Hauv kev kos duab ntxiv rau lub cev, tus neeg mob tau muab tshuaj thiab tom qab ntawd qee qhov ntshav ntawm lub cev coj los ntawm lub cev, muab tso rau hauv qhov tshwj xeeb ultraviolet A teeb, thiab muab rov qab rau hauv lub cev. Kev siv tshuaj tua kab mob ntxiv yuav siv ib leeg lossis ua ke nrog tag nrho cov tawv nqaij hluav taws xob nqaj (TSB) kev kho hluav taws xob.

Kev siv hluav taws xob

Kev xoo hluav taws xob yog kev kho mob cancer uas siv hluav taws xob xoo hluav taws xob loj lossis lwm yam hluav taws xob tua ntau los tua cov qog nqaij hlav cancer lossis ua kom lawv loj tuaj. Kev siv hluav taws xob sab nraud siv lub tshuab sab nraud lub cev xa cov hluav taws xob mus rau thaj tsam ntawm lub cev nrog mob qog noj ntshav. Qee zaum, tag nrho cov nqaij ntshiv hluav taws xob (TSB) kev kho hluav taws xob tau siv los kho mycosis fungoides thiab Sézary syndrome. Qhov no yog ib hom kev kho hluav taws xob sab nraud nyob rau hauv uas lub tshuab hluav taws xob tsom siv hluav taws xob ua hluav taws xob (me me, qhov me tsis pom) ntawm daim tawv npog tag nrho lub cev. Kev kho hluav taws xob sab nraud kuj tseem siv tau ua kev kho mob palliative kom txo cov tsos mob thiab txhim kho lub neej zoo.

Kev siv hluav taws xob tua UV hluav taws xob lossis UV hluav taws xob tua UV hluav taws xob yog siv cov teeb ci tshwj xeeb lossis cov duab laser uas qhia ncaj qha rau ntawm daim tawv nqaij.

Kws khomob

Kev siv tshuaj kho mob yog kev kho mob cancer uas siv cov tshuaj los txwv kev loj hlob ntawm cov qog nqaij hlav cancer, los ntawm kev tua cov qog lossis txwv tsis pub faib. Thaum cov tshuaj tua kab mob noj los ntawm qhov ncauj lossis txhaj rau hauv txoj hlab ntshav lossis leeg, cov tshuaj nkag mus rau cov ntshav thiab tuaj yeem mus txog rau cov qog nqaij hlav ntshav thoob plaws lub cev (kev kho mob tshuaj tua kabmob). Qee zaum siv tshuaj tua kab mob yog tshuaj pleev (muab tso rau ntawm daim tawv nqaij ua tshuaj pleev, pleev tshuaj, lossis pleev pleev).

Saib Cov Tshuaj Pom Zoo rau Kev Tsis-Hodgkin Lymphoma yog xav paub ntxiv. (Mycosis fungoides thiab Sézary syndrome yog hom tsis mob Hodgkin lymphoma.)

Lwm txoj kev kho tshuaj

Cov tshuaj pleev corticosteroids yog siv los daws cov xim liab, o, thiab tawv nqaij. Lawv yog hom qauv steroid. Cov tshuaj pleev corticosteroids tuaj yeem yog hauv qab zib, tshuaj pleev, lossis pleev pleev.

Retinoids, xws li bexarotene, yog cov tshuaj cuam tshuam nrog cov vitamin A uas tuaj yeem ua rau qeeb kev loj hlob ntawm qee hom qog ntshav hlav. Tus retinoids tuaj yeem noj ntawm lub qhov ncauj lossis muab tso rau ntawm daim tawv nqaij.

Lenalidomide yog cov tshuaj uas pab lub cev tiv thaiv kab mob tua cov ntshav tsis txaus lossis cov qog nqaij hlav cancer thiab tuaj yeem tiv thaiv kev loj hlob ntawm cov hlab ntshav tshiab uas cov qog yuav tsum loj hlob.

Vorinostat thiab romidepsin yog ob qho ntawm cov histone deacetylase (HDAC) inhibitors siv los kho mycosis fungoides thiab Sézary syndrome. Cov tshuaj tiv thaiv HDAC ua rau muaj kev hloov tshuaj uas txwv cov qog ntshav ntawm kev faib khoom.

Saib Cov Tshuaj Pom Zoo rau Kev Tsis-Hodgkin Lymphoma yog xav paub ntxiv. (Mycosis fungoides thiab Sézary syndrome yog hom tsis mob Hodgkin lymphoma.)

Kev Txhaj Tshuaj Tiv Thaiv

Kev Siv Tshuaj Tiv Thaiv yog ib txoj kev kho mob uas siv tus neeg mob lub cev tiv thaiv kab mob cancer. Cov tshuaj uas tsim los ntawm lub cev lossis tsim hauv chav siv tshuaj yog siv los txhawb, ncaj qha, lossis rov kho lub cev lub cev los tiv thaiv tus mob qog nqaij hlav. Hom kev kho mob cancer no tseem hu ua biotherapy lossis biologic therapy.

• Interferon: Qhov kev kho mob no cuam tshuam nrog kev faib tawm mycosis fungoides thiab Sézary hlwb thiab tuaj yeem qeeb qog ua qog.

Saib Cov Tshuaj Pom Zoo rau Kev Tsis-Hodgkin Lymphoma yog xav paub ntxiv. (Mycosis fungoides thiab Sézary syndrome yog hom tsis mob Hodgkin lymphoma.)

Cov hom phiaj kho

Hom phiaj kho yog ib hom kev kho mob uas siv tshuaj lossis lwm yam tshuaj los tua cov qog noj ntshav. Cov hom phiaj kho feem ntau ua rau tsis muaj kev phom sij rau cov hlwb ib txwm dua li kev kho tshuaj lossis hluav taws xob kho.

• Monoclonal antibody therapy: Qhov kev kho no siv cov tshuaj tiv thaiv uas ua hauv chav kuaj los ntawm ib hom kab mob ntawm cov kab mob tiv thaiv kab mob. Cov tshuaj tiv thaiv no tuaj yeem txheeb xyuas cov tshuaj ntawm qog nqaij hlav cancer lossis cov khoom qub uas tuaj yeem pab ua kom cov cell mob qog noj ntshav. Cov tshuaj tiv thaiv txuas rau cov tshuaj thiab tua cov qog nqaij hlav cancer, thaiv lawv qhov kev loj hlob, lossis txwv tsis pub kis mus rau lwm qhov. Lawv yuav raug siv nyob ib leeg lossis nqa tshuaj, co toxins, lossis khoom siv hluav taws xob ncaj qha mus rau qog nqaij hlav cancer. Cov kab mob monoclonal yog muab los ntawm kev lis ntshav.

Hom kab mob monoclonal muaj xws li:

• Brentuximab vedotin, uas muaj cov monoclonal antibody uas khi rau cov protein, hu ua CD30, pom nyob rau qee hom qog ua ntshav. Nws tseem muaj cov tshuaj anticancer uas tuaj yeem pab tua cov kabmob kheesxaws.

• Mogamulizumab, uas muaj cov monoclonal antibody uas khi rau cov protein, hu ua CCR4, pom muaj qee hom qog ua ntshav. Nws yuav thaiv cov protein no thiab pab kom lub cev tua cov kab mob qog ntshav. Nws raug siv los kho mycosis fungoides thiab Sézary syndrome uas tau rov qab los yog tsis zoo dua tom qab kho nrog tsawg kawg ib qho kev kho mob.

Kev siv tshuaj kho mob ntau dua thiab kev kho hluav taws xob nrog kev hloov pauv ntawm qia

Kev txhaj tshuaj siab ntau thiab qee zaum muab tshuaj tua hluav taws xob rau tua cov qog noj ntshav. Cov kab mob noj qab haus huv, suav nrog cov qe tsim cov ntshav, kuj raug rhuav tshem los ntawm kev kho mob qog noj ntshav. Kev hloov ntawm qia yog kev kho mob los hloov cov qe tsim cov qe ntshav. Cov qia hlwb (cov qe ntshav tsis txaus) raug tshem tawm los ntawm cov ntshav lossis pob txha mob ntawm tus neeg mob lossis tus neeg pub ntshav thiab raug khov thiab khaws cia. Tom qab tus neeg mob ua tiav kev kho mob tshuaj thiab tshuaj kho hluav taws xob, lub qia hlwb raug yaj thiab muab rov qab rau tus neeg mob los ntawm kev hla tshuaj. Cov qog ntshav qog ua kom loj hlob mus rau (thiab txum tim) lub cev cov ntshav.

Cov hom kev kho mob tshiab tau raug sim hauv qhov kev sim kho mob.

Cov ntaub ntawv hais txog kev sim kho mob muaj nyob rau ntawm NCI lub vev xaib.

Kev kho rau mycosis fungoides thiab Sézary syndrome yuav ua rau muaj kev phiv.

Yog xav paub txog cov kev mob tshwm sim los ntawm kev kho mob qog noj ntshav, saib peb Sab Phiv Rov Qab.

Cov neeg mob yuav xav txog kev sim kho mob.

Txog qee tus neeg mob, koom nrog kev sim kho mob yuav yog txoj kev xaiv zoo tshaj plaws. Cov chaw kuaj mob yog ib feem ntawm cov txheej txheem tshawb mob qog noj ntshav. Cov chaw kho mob tau sim ua kom pom tias kev kho mob qog noj ntshav tshiab muaj kev nyab xeeb thiab zoo dua lossis zoo dua cov qauv tshuaj.

Ntau yam ntawm cov qauv kev kho mob qog noj ntshav niaj hnub no yog los ntawm cov kev tshawb fawb kab mob thaum ntxov. Cov neeg mob uas koom nrog kev sim kho mob tuaj yeem tau txais cov qauv kev kho mob lossis ua thawj zaug tau txais kev kho mob tshiab.

Cov neeg mob uas koom nrog kev sim kho mob kuj pab txhim kho txoj kev kho mob qog nqaij hlav yav tom ntej. Txawm hais tias kev sim tshuaj sim tsis ua rau muaj kev kho mob tshiab, lawv feem ntau teb cov lus nug tseem ceeb thiab pab txav kev tshawb fawb tom ntej.

Cov neeg mob tuaj yeem nkag mus kuaj mob ua ntej, sijhawm, lossis tom qab pib kho mob qog noj ntshav.

Qee qhov kev sim tshuaj tsuas yog suav nrog cov neeg mob uas tseem tsis tau txais kev kho mob. Lwm txoj kev sim sim cov kev kho mob rau cov neeg mob uas mob qog noj qab tsis tau zoo dua. Kuj tseem muaj cov kev sim tshuaj kuaj mob uas sim txoj kev tshiab los txwv qog noj ntshav kom tsis txhob mob ntxiv (rov qab los) lossis txo kev phiv los ntawm kev kho mob qog noj.

Cov chaw kuaj mob tau tshwm sim nyob rau ntau lub tebchaws. Cov ntaub ntawv hais txog kev sim kho mob uas tau txhawb nqa los ntawm NCI tuaj yeem nrhiav pom ntawm NCI cov chaw kuaj mob tshawb nrhiav lub vev xaib. Cov chaw kuaj mob txhawb nqa los ntawm lwm cov koomhaum tuaj yeem nrhiav pom ntawm ClinicalTrials.gov lub vev xaib.

Tej zaum yuav tau ua raws li kev ntsuam xyuas.

Qee qhov kev ntsuas mob uas tau ntsuas los kuaj mob qog noj ntshav lossis kom pom tias theem mob cancer yuav rov qab ua dua. Qee qhov kev ntsuas yuav rov ua qhov qub txhawm rau kom pom tias qhov kev kho mob ua haujlwm li cas. Cov kev txiav txim siab hais txog seb puas yuav txuas ntxiv, hloov, lossis tsum tsis mus kho yuav ua raws cov txiaj ntsig ntawm cov kev ntsuas no.

Qee qhov kev sim yuav txuas ntxiv ua ib zaug dhau ib zaug tom qab kho tas. Qhov tshwm sim ntawm kev sim no tuaj yeem qhia tau yog tias koj tus mob tau hloov lossis yog tias mob qog rov qab (rov qab los). Qee qhov kev ntsuas no qee zaum hu ua kev kuaj mob rov qab lossis mus kuaj mob.

Kev Kho Mob Ntu I thiab Theem II Mycosis Fungoides

Yog xav paub txog cov kev kho mob uas teev rau hauv qab no, saib hauv Cov Lus Qhia Kev Xaiv Kev Xaiv.

Kev kho cov kab mob tshiab ntu I thiab theem II mycosis fungoides yuav suav nrog cov hauv qab no:

• Psoralen thiab ultraviolet A (PUVA) kev kho hluav taws xob.

• Ultraviolet B kev kho hluav taws xob.

• Kev siv hluav taws xob kho nrog tag nrho cov tawv nqaij hluav taws xob nqaj hluav taws xob kho. Muaj qee kis, kev kho mob hluav taws xob tau muab rau cov tawv nqaij tawv nqaij, raws li kev kho mob palliative kom txo cov qog loj me los daws qhov mob thiab txhim kho lub neej zoo.

• Kev txhaj tshuaj tiv thaiv kab mob ib leeg lossis ua ke nrog kev kho kom ncaj qha rau ntawm daim tawv nqaij.

• Tshuaj pleev ib ce.

• Tshuaj thev naus laus zis nrog ib los yog ntau cov tshuaj, uas tej zaum yuav nrog ua ke nrog kev kho mob raws daim tawv nqaij.

• Lwm txoj kev kho tshuaj (tshuaj pleev ib ce corticosteroids, kho mob retinoid, lenalidomide, histone deacetylase inhibitors).

• Hom phiaj kho (brentuximab vedotin).

Siv peb qhov kev tshawb nrhiav kab mob hauv tsev kho mob kom pom qhov NCI-txhawb nqa kev mob qog nqaij hlav uas pom zoo rau cov neeg mob. Koj tuaj yeem tshawb xyuas cov kev sim raws li hom mob cancer, hnub nyoog ntawm tus neeg mob, thiab qhov chaw uas sim kev sim. Cov ncauj lus dav dav txog kev sim kho mob kuj muaj.

Kev Kho Mob Ntu III thiab Theem IV Mycosis Fungoides (Nrog rau Sézary Syndrome)

Yog xav paub txog cov kev kho mob uas teev rau hauv qab no, saib hauv Cov Lus Qhia Kev Xaiv Kev Xaiv.

Kev kho mob ntawm nyuam qhuav pib mob theem III thiab theem IV mycosis fungoides suav nrog Sézary syndrome yog palliative (txhawm rau txo cov tsos mob thiab txhim kho lub neej muaj txiaj ntsig) thiab yuav suav nrog cov hauv qab no:

• Psoralen thiab ultraviolet A (PUVA) kev kho hluav taws xob.

• Ultraviolet B kev kho hluav taws xob.

• Cov kev yees duab sab nrauv ntxiv los ua ib leeg lossis ua ke nrog tag nrho cov tawv nqaij hluav taws xob kho cov duab hluav taws xob.

• Kev siv hluav taws xob kho nrog tag nrho cov tawv nqaij hluav taws xob nqaj hluav taws xob kho. Muaj qee kis, kev kho mob hluav taws xob tau muab rau cov tawv nqaij tawv nqaij, raws li kev kho mob palliative kom txo cov qog loj me los daws qhov mob thiab txhim kho lub neej zoo.

• Kev txhaj tshuaj tiv thaiv kab mob ib leeg lossis ua ke nrog kev kho kom ncaj qha rau ntawm daim tawv nqaij.

• Tshuaj thev naus laus zis nrog ib los yog ntau cov tshuaj, uas tej zaum yuav nrog ua ke nrog kev kho mob raws daim tawv nqaij.

• Tshuaj pleev ib ce.

• Lwm txoj kev kho tshuaj (tshuaj pleev ib ce corticosteroids, lenalidomide, bexarotene, histone deacetylase inhibitors).

• Hom phiaj kho nrog brentuximab vedotin.

Siv peb qhov kev tshawb nrhiav kab mob hauv tsev kho mob kom pom qhov NCI-txhawb nqa kev mob qog nqaij hlav uas pom zoo rau cov neeg mob. Koj tuaj yeem tshawb xyuas cov kev sim raws li hom mob cancer, hnub nyoog ntawm tus neeg mob, thiab qhov chaw uas sim kev sim. Cov ncauj lus dav dav txog kev sim kho mob kuj muaj.

Kev Kho Mob Ntawm Cov Mob Mycosis Fungoides (suav nrog Sézary Syndrome)

Yog xav paub txog cov kev kho mob uas teev rau hauv qab no, saib hauv Cov Lus Qhia Kev Xaiv Kev Xaiv.

Cov mob ua paug mycosis fungoides thiab Sézary syndrome tau rov qab los rau ntawm daim tawv nqaij lossis lwm qhov hauv lub cev tom qab lawv tau raug kho.

Kev kho cov kab mob hu ua mycosis fungoides suav nrog Sézary syndrome yuav tshwm sim hauv qhov kev sim tshuaj thiab yuav suav nrog cov hauv qab no:

• Kev siv hluav taws xob kho nrog tag nrho cov tawv nqaij hluav taws xob nqaj hluav taws xob kho. Muaj qee kis, kev kho hluav taws xob yog muab rau cov tawv nqaij raws li kev kho mob palliative kom txo cov qog ntshav kom loj me kom txo cov tsos mob thiab txhim kho lub neej zoo.

• Psoralen thiab ultraviolet A (PUVA) kev kho hluav taws xob, uas tej zaum yuav muab nrog tshuaj tiv thaiv kab mob.

• Ultraviolet B hluav taws xob.

• Kev Siv Tshuaj Tiv Thaiv Sab Nrauv.

• Tshuaj mentsis tshuaj nrog rau ib lossis ntau yam tshuaj.

• Lwm txoj kev kho tshuaj (tshuaj pleev ib ce corticosteroids, kho mob retinoid, lenalidomide, histone deacetylase inhibitors).

• Kev txhaj tshuaj tiv thaiv kab mob ib leeg lossis ua ke nrog kev kho kom ncaj qha rau ntawm daim tawv nqaij.

• Kev siv tshuaj kho mob siab, thiab qee zaum siv hluav taws xob kho, nrog hloov qia hauv hlwb.

• Hom phiaj kho (brentuximab vedotin lossis mogamulizumab).

Siv peb qhov kev tshawb nrhiav kab mob hauv tsev kho mob kom pom qhov NCI-txhawb nqa kev mob qog nqaij hlav uas pom zoo rau cov neeg mob. Koj tuaj yeem tshawb xyuas cov kev sim raws li hom mob cancer, hnub nyoog ntawm tus neeg mob, thiab qhov chaw uas sim kev sim. Cov ncauj lus dav dav txog kev sim kho mob kuj muaj.

Yog Xav Paub Ntxiv Txog Mycosis Fungoides thiab Sézary Syndrome

Yog xav paub ntxiv los ntawm National Cancer Institute txog mycosis fungoides thiab Sézary syndrome, saib cov hauv qab no:

• Lymphoma Tsev Nplooj Ntawv

• Photodynamic Kev Kho Mob Cancer

• Tshuaj Pom Zoo rau Cov Tshuaj Uas Tsis Yog Hodgkin Lymphoma

• Tshuaj Kho Mob Los Kho Mob Cancer

• Hom Kab Mob Kuaj Mob Cancer

Txog kev qhia txog kabmob kheesxaws thoob plaws thiab lwm yam kev pabcuam los ntawm National Cancer Institute, saib cov hauv qab no:

• Txog Mob Cancer

• Qib

• Kev Siv Tshuaj Kho Mob thiab Koj: Txhawb Rau Cov Neeg Muaj Mob Cancer

• Qhov Kev Mob Hlaws Hluav Taws Xob thiab Koj: Txhawb Rau Cov Neeg Muaj Mob Cancer

• Kev Muaj Mob Cancer

• Cov Lus Nug Yuav Nug Koj Tus Kws Kho Mob txog Kab Mob Cancer

• Rau Cov Muaj Txoj Sia Nyob thiab Cov Saib Xyuas