Types/lymphoma/patient/adult-nhl-treatment-pdq

Kev Kho Mob Tsis Muaj Hodgkin Lymphoma Kev Kho Mob (®) atPatient Version

Cov Lus Qhia Txog Cov Laus Tsis Yog Hodgkin Lymphoma

QHOV TSEEM CEEB

• Tsis-Hodgkin lymphoma yog ib tug kab mob uas cov hlwb mob qog ua qog ua ntshav nyob rau hauv cov qog ntshav.

• Cov-Hodgkin lymphoma tuaj yeem tsis tuaj yeem lossis quab yuam.

• Cov hnub nyoog laus dua, ua txiv neej, thiab lub cev tsis muaj zog tiv thaiv kab mob tuaj yeem ua rau muaj kev pheej hmoo rau cov neeg laus tsis mob Hodgkin lymphoma.

• Cov tsos mob thiab cov tsos mob ntawm cov neeg laus tsis-Hodgkin lymphoma suav nrog cov qog ntshav o, ua npaws, tawm hws hmo ntuj, yuag, thiab qaug zog.

• Kev ntsuam xyuas uas kuaj cov lymph system thiab lwm qhov hauv lub cev tau siv los pab kuaj thiab theem cov neeg laus tsis-Hodgkin lymphoma.

• Qee yam cuam tshuam txog kev raug (mob rov qab) thiab txoj kev kho.

Tsis-Hodgkin lymphoma yog ib tug kab mob uas cov hlwb mob qog ua qog ua ntshav nyob rau hauv cov qog ntshav.

Tsis-Hodgkin lymphoma yog hom mob cancer uas ua rau cov qog ntshav. Lub lymph ua haujlwm yog ib feem ntawm lub cev tiv thaiv kab mob. Nws pab tiv thaiv lub cev los ntawm kev kis kab mob thiab kab mob.

Lymph lub cev yog ua los ntawm cov hauv qab no:

• Lymph: Tsis muaj kob, kua dej uas ntws los ntawm cov qog ntshav thiab nqa cov lymphocytes (cov qe ntshav dawb). Muaj peb hom lymphocytes:

• B lymphocytes uas ua kom muaj cov tshuaj tiv thaiv kab mob los pab tua kab mob. Kuj hu ua B cell. Feem ntau hom tsis-Hodgkin lymphoma pib hauv B lymphocytes.

• T lymphocytes uas pab B lymphocytes ua rau cov tshuaj tiv thaiv uas pab tua kab mob sib kis. Kuj tseem hu ua T cell.

• Tus kab mob tua neeg uas tua cov qog noj ntshav thiab kab mob. Kuj tseem hu ua NK hlwb.

• Lymph hlab ntsha (hlab ntsws): Lub network ntawm txoj hlab nyias nyias uas sau cov qog ntawm ntau qhov ntawm lub cev thiab xa rov qab rau cov ntshav.

• Cov qog ntshav: Lub cev me, taum pauv uas lim cov qog thiab khaws cov qe ntshav dawb uas pab tawm tsam kev kis mob thiab kab mob. Cov qog tau nyob raws cov kab ke sib txuas ntawm cov qog ntshav thoob plaws lub cev. Cov pab pawg ntawm cov qog ntshav tau pom nyob hauv caj dab, underarm, mediastinum, plab, pelvis, thiab puab tais.

• Spleen: Ib qho khoom hauv nruab nrog uas ua cov lymphocytes, khaws cov qe ntshav liab thiab lymphocytes, lim ntshav, thiab rhuav cov qe ntshav qub. Tus po yog pob nyob rau sab laug ntawm lub plab ze rau lub plab.

• Thymus: Ib qho khoom hauv lub cev uas T lymphocytes paub tab thiab hlav ntau. Tus qa yog hauv siab hauv qab lub mis.

• Tonsils: Ob qhov loj me ntawm cov qog ntshav ntawm sab caj pas. Muaj ib tonsil ntawm ib sab ntawm caj pas.

• Hlwb Pob Txha: Cov nqaij mos thiab pob txha mos nyob hauv qhov chaw ntawm qee cov pob txha, xws li pob txha pob txha thiab txhaws. Cov qe ntshav dawb, qe ntshav liab thiab cov qe ntshav ua rau cov hlwb pob txha.

Lub cev qog ntawm cov qog ntshav, uas qhia cov hlab ntsha thiab cov qog ua haujlwm nrog rau cov qog ntshav, tonsils, thymus, spleen, thiab pob txha pob txha. Lymph (kua dej ntshiab) thiab lymphocytes taug kev hauv cov hlab ntsha mus rau hauv cov qog ntshav uas cov lymphocytes ua kom puas cov tshuaj phem. Lymph nkag hauv ntshav los ntawm txoj hlab ntshav loj nyob ze lub plawv.

Cov qog ua kua kuj tseem nyob hauv lwm qhov chaw ntawm lub cev xws li hauv ob sab phlu ntawm txoj hnyuv zom zaub mov, mob ntsws, thiab tawv nqaij. Cov kab mob khees xaws tuaj yeem kis rau daim siab thiab mob ntsws.

Muaj ob hom mob lymphomas: Hodgkin lymphoma thiab tsis-Hodgkin lymphoma. Cov ntsiab lus no yog hais txog kev kho mob rau cov neeg laus tsis mob Hodgkin lymphoma, suav nrog thaum cev xeeb tub.

Yog xav paub txog lwm hom qog ntshav, saib cov lus hauv qab no :

• Cov Neeg Mob Loj Lymphoblastic Kev Mob Ntshav Qab Zib

• Kho Cov Neeg Loj Hlob Hodgkin

• Kev Kho Tus Mob AIDS-Txog Lymphoma

• Thaum yau Tsis-Hodgkin Lymphoma Kev Kho

• Kho Mob Lymphocytic Mob Hlwb Ntev (ua mob me me lyymhocytic lymphoma)

• Kev Kho Tus Mob Mycosis Fungoides (Nrog Rau Mob Sézary Syndrome) Kev Kho Mob (txiav tawm T-cell lymphoma)

• Kev Kho Tus Mob CNS Qeb Qeb Thawj

Cov-Hodgkin lymphoma tuaj yeem tsis tuaj yeem lossis quab yuam.

Tsis-Hodgkin lymphoma hlav thiab sib kis ntawm ntau tus nqi thiab tuaj yeem tsis nco qab lossis txhoj puab. Indolent lymphoma zoo li yuav loj hlob thiab kis qeeb, thiab muaj qee qhov cim thiab tsos mob. Kev mob qog ua kua loj hlob thiab huam vam sai, thiab muaj cov tsos mob thiab tus mob uas tuaj yeem ua tau mob hnyav. Cov kev kho rau qhov tsis txaus ntseeg thiab mob qog nqaij hlav txawv.

Cov ntsiab lus luv luv no yog hais txog hom qog ntshav tsis-Hodgkin lymphoma:

Indolent tsis-Hodgkin lymphomas

Tshwj xeeb ua qog ntshav. Follicular lymphoma yog qhov ntau hom tshaj plaws ntawm qhov tsis paub qhov tseeb Hodgkin lymphoma. Nws yog hom qeeb heev uas tsis-Hodgkin lymphoma uas pib hauv B lymphocytes. Nws ua mob rau cov qog ntshav thiab kis rau tus pob txha pob txha los yog hnoos qeev. Feem ntau cov neeg mob ua pob hlav ntawm cov leeg muaj hnub nyoog 50 xyoo thiab laus dua thaum lawv kuaj pom. Cov kab mob ntsws tshwj xeeb yuav ploj mus yam tsis muaj kev kho. Tus neeg mob tau saib xyuas ze rau cov cim los yog tsos mob tias tus kab mob tau rov qab muaj dua. Kev kho yog qhov xav tau yog tias cov cim lossis cov tsos mob tshwm sim tom qab mob cancer ploj lossis tom qab pib kho cancer. Qee zaum lymphoma follicular tuaj yeem dhau los ua ntau hom qog ntshav, xws li diffuse loj B-cell lymphoma.

Lymphoplasmacytic lymphoma. Feem ntau ntawm cov mob lymphoplasmacytic lymphoma, B lymphocytes uas hloov mus rau cov ntshav ntshav ua cov protein ntau uas hu ua monoclonal immunoglobulin M (IgM) cov tshuaj tiv thaiv. Theem ntawm IgM lub cev tiv thaiv kab mob hauv cov ntshav ua rau cov ntshav ntshav tuab. Qhov no tuaj yeem ua cov paib lossis cov tsos mob xws li teeb meem pom lossis hnov ​​lus, teeb meem plawv, ua pa luv, mob taub hau, kiv taub hau, thiab dias lossis nkees lossis twm ntawm tes thiab taw. Qee lub sijhawm tsis muaj cov cim lossis tsos mob ntawm tus mob lymphoplasmacytic lymphoma. Nws yuav pom thaum kuaj ntshav ntxiv rau lwm qhov laj thawj. Lymphoplasmacytic lymphoma feem ntau kis mus rau cov hlwb pob txha, cov qog ntshav, thiab nti. Cov neeg muaj mob qog ua lub siab ntsws cov ntsws lymphoma yuav tsum mus kuaj ntawm tus kab mob siab C kis tus kab mob siab. Nws kuj tseem hu ua Waldenström macroglobulinemia.

Marginal tsam lymphoma. Hom tsis mob Hodgkin lymphoma pib hauv B lymphocytes hauv ib feem ntawm cov qog ntshav hu ua marginal tsam. Qhov tshwm sim yuav mob hnyav dua rau cov neeg mob hnub nyoog 70 xyoo lossis laus dua, cov muaj theem III lossis theem IV, thiab cov neeg muaj lactate dehydrogenase (LDH) ntau ntau. Muaj tsib yam sib txawv ntawm marginal tsam lymphoma. Lawv yog pawg raws hom ntawm cov nqaij ua qhov nqaij lymphoma tsim:

• Nodal marginal tsam lymphoma. Nodal marginal cheeb tsam cov qog ntshav hauv cov qog ntshav. Hom mob tsis yog Hodgkin lymphoma no muaj tsawg. Nws kuj tseem hu ua monocytoid B-cell lymphoma.

• Gastric mucosa-txuam nrog lymphoid nqaij (MALT) lymphoma. Gastric MALT lymphoma feem ntau pib hauv lub plab. Hom kab mob qog mob no ua rau cov cell nyob hauv mucosa uas pab ua cov tshuaj tiv thaiv kab mob. Cov neeg mob uas muaj mob plab MALT lymphoma kuj tseem muaj Helicobacter gastritis lossis tus kabmob autoimmune, xws li Hashimoto thyroiditis lossis Sjögren syndrome.

• Extragastric MALT lymphoma. Extragastric MALT lymphoma pib tawm sab nraud ntawm lub plab hauv yuav luag txhua qhov ntawm lub cev nrog rau lwm qhov ntawm lub plab zom mov, cov qog ua kua qaub, lub qog, lub ntsws, tawv nqaij, thiab ncig lub qhov muag. Hom kab mob qog mob no ua rau cov cell nyob hauv mucosa uas pab ua cov tshuaj tiv thaiv kab mob. Extragastric MALT lymphoma tuaj yeem rov qab ntau xyoo tom qab kev kho mob.

• Mediterranean paum lymphoma. Qhov no yog ib hom MALT lymphoma uas tshwm sim rau cov neeg hluas nyob rau sab hnub tuaj Mediterranean. Nws feem ntau ua rau hauv plab thiab cov neeg mob kuj tseem yuav kis tau tus kab mob hu ua Campylobacter jejuni. Hom qog ntshav no tseem hu ua immunoproliferative me kab mob plab hnyuv.

• Tej yam tsis txaus ntseeg hais qhov tsis txaus ntseeg. Hom mob marginal lymphoma no pib ua tus po thiab yuav kis mus rau cov leeg ntshav thiab mob hlwb. Cov phiajcim uas nquag pom ntawm hom splenic marginal lymphoma no yog tus po ntev uas loj dua li ib txwm.

Thawj qhov kev txiav cov kab mob ntshav ntau lub qog ua pob. Hom tsis mob Hodgkin lymphoma nyob hauv daim tawv xwb. Nws tuaj yeem yog qhov mob benign (tsis yog mob qog nqaij hlav) uas yuav ploj mus ntawm nws tus kheej lossis nws tuaj yeem kis mus rau ntau qhov chaw ntawm daim tawv nqaij thiab xav tau kev kho mob.

Aggressive tsis-Hodgkin lymphomas

Diffuse loj B-cell lymphoma. Diffuse loj B-cell lymphoma yog hom feem ntau ntawm qhov tsis-Hodgkin lymphoma. Nws loj hlob sai nyob hauv cov qog ntshav thiab feem ntau yog tus po, mob siab, mob pob txha, lossis lwm yam hauv lub nruab nrog cev. Cov tsos mob thiab cov tsos mob ntawm diffuse loj B-cell lymphoma tuaj yeem suav nrog ua npaws, tawm hws hmo ntuj, thiab ua rau poob phaus. Cov no kuj hu ua cov tsos mob B.

• Thawj theem mediastinal loj B-cell lymphoma. Hom mob uas tsis yog Hodgkin lymphoma yog hom diffuse loj B-cell lymphoma. Nws yog cim los ntawm overgrowth ntawm fibrous (caws pliav-xws li) cov qog ua kua. Cov qog feem ntau ua rau qab ntawm lub mis. Nws yuav nias rau ntawm lawv cov hlab pa thiab ua rau hnoos thiab ua pa nyuaj. Feem ntau ntawm cov neeg mob uas muaj tus thawj mediastinal loj B-cell lymphoma yog cov poj niam uas muaj hnub nyoog 30 txog 40 xyoo.

Cov kab mob cell qog tshwj xeeb loj, theem III. Cov kab mob qog nqaij hlav hauv lub cev loj, theem III, yog ib hom muaj ntshav tsawg-Hodgkin lymphoma. Kev kho tus mob follicular lymphoma no zoo dua li kev kho mob ntawm NHL kev txhoj puab heev dua li ntawm NHL.

Anaplastic cov cell loj lymphoma. Anaplastic cell loj lymphoma yog ib hom tsis yog Hodgkin lymphoma uas feem ntau pib ua haujlwm hauv T lymphocytes. Cov kab mob ua cancer kuj tseem muaj qhov cim hu ua CD30 nyob rau saum npoo ntawm lub cell.

Muaj ob hom anaplastic cell loj lymphoma:

• Cutaneous anaplastic loj cell lymphoma. Qhov hom mob anaplastic loj ntawm tes lymphoma feem ntau cuam tshuam rau daim tawv nqaij, tab sis lwm qhov ntawm lub cev kuj tseem muaj cuam tshuam. Cov cim ntawm cutaneous anaplastic loj cell lymphoma suav nrog ib lossis ntau dua ua pob lossis mob rau ntawm daim tawv nqaij. Hom qog no tsis tshua pom kev thiab tsis pom qab.

• Systemic anaplastic cov cell loj ua haujlwm. Qhov hom mob anaplastic cell loj ua ntej lub qog ntshav thiab yuav cuam tshuam rau lwm qhov ntawm lub cev. Hom qog no siv zog ntau dua. Cov neeg mob tej zaum yuav muaj ntau cov anaplastic lymphoma kinase (ALK) protein ntau nyob hauv cov lymphoma. Cov neeg mob no tau raug kwv yees zoo dua li cov neeg mob uas tsis muaj cov protein ntau ALK ntxiv. Cov kab mob hauv lub cev cov pob txha ua qog ua ntau nyob rau cov menyuam yaus dua li cov neeg laus. (Saib cov ntsiab lus hais txog Kev Menyuam Tsis Yog Hodgkin Lymphoma Kev Kho Mob rau cov lus qhia ntxiv.)

• Extranodal NK- / T-cell lymphoma. Extranodal NK- / T-cell lymphoma feem ntau pib hauv thaj chaw ncig lub qhov ntswg. Nws kuj tseem tuaj yeem cuam tshuam rau qhov txha caj qaum txhaws (qhov chaw nyob hauv pob txha ncig lub qhov ntswg), lub ru tsev ntawm lub qhov ncauj, lub plab, tawv nqaij, plab, thiab plab hnyuv. Feem ntau ntawm extranodal NK- / T-cell lymphoma muaj Epstein-Barr tus kab mob hauv cov qog hlwb. Qee zaum cov hemophagocytic syndrome tshwm sim (qhov mob hnyav uas muaj ntau cov histiocytes thiab T ua rau lub cev ua rau mob hnyav hauv lub cev). Yuav tsum kho los kho kom lub cev tiv thaiv tsis muaj zog. Hom kab mob tsis haum Hodgkin lymphoma tsis yog hom muaj ntau nyob hauv Tebchaws Meskas.

• Lymphomatoid granulomatosis. Lymphomatoid granulomatosis feem ntau cuam tshuam rau lub ntsws. Nws kuj tseem tuaj yeem cuam tshuam rau qhov txha caj qaum txhaws (qhov chaw tsis muaj pob txha nyob ib ncig ntawm lub qhov ntswg), tawv nqaij, raum, thiab lub paj hlwb. Hauv cov lymphomatoid granulomatosis, mob cancer tua cov hlab ntshav thiab tua cov nqaij mos. Vim hais tias mob cancer yuav kis mus rau lub hlwb, kev qhia tshuaj kho mob lossis hluav taws xob kho rau lub hlwb tau txais.

• Angioimmunoblastic T-cell lymphoma. Hom mob uas tsis yog Hodgkin lymphoma pib hauv T cell. Cov qog ntshav o yog cov uas keev pom. Lwm yam tsos mob kuj muaj xws li ua pob khaus tawv, ua npaws, yuag, lossis tawm hws hmo ntuj. Tseem yuav muaj theem ntawm gamma globulin (tshuaj tiv thaiv) nyob rau hauv cov ntshav. Cov neeg mob kuj tseem tuaj yeem muaj mob txeeb zig vim tias lawv lub cev tiv thaiv kab mob tsis muaj zog.

• Peripheral T-cell lymphoma. Peripheral T-cell lymphoma pib paub tab ly lyhoho lymphocytes. Hom T lymphocyte no hlob nyob rau hauv lub qog thymus thiab mus rau lwm qhov chaw lymphatic hauv lub cev xws li cov qog ntshav, hlwb pob txha, thiab hno qeev. Muaj peb subtypes ntawm peripheral T-cell lymphoma:

• Hepatosplenic T-cell lymphoma. Qhov no yog yam tsis txawv txav ntawm qhov tsis taus ntawm T-cell lymphoma uas tshwm sim feem ntau rau cov txiv neej hluas. Nws pib nyob rau hauv daim siab thiab tus po thiab cov qog nqaij hlav cancer kuj tseem muaj T-cell receptor hu ua gamma / raws ntawm lub cell.

• Tus mob hlwv pob txha mos zoo li T-cell mob cancer. Mob pob txaws Subcutaneous panniculitis zoo li T-cell lymphoma pib ntawm daim tawv nqaij los yog hnoos qeev. Nws yuav tshwm sim nrog hemophagocytic syndrome (ib qho mob hnyav uas muaj ntau cov histiocytes thiab T ua rau lub cev ua rau mob hnyav hauv lub cev). Yuav tsum kho los kho kom lub cev tiv thaiv tsis muaj zog.

• Enteropathy-yam mob hnyuv T-cell lymphoma. Hom peripheral T-cell lymphoma no tshwm sim nyob rau hauv plab me me ntawm cov neeg mob uas tsis kho tus mob celiac (tiv thaiv kab mob rau gluten uas ua rau lub cev tsis zoo). Cov neeg mob uas kuaj pom tias muaj tus kab mob celiac thaum yau thiab nyob ntawm cov zaub mov tsis muaj gluten tsis tshua muaj mob enteropathy-mob hnyuv T-cell lymphoma.

• Intravascular loj B-cell lymphoma. Hom ntshav tsis-Hodgkin lymphoma cuam tshuam txog cov hlab ntshav, tshwj xeeb tshaj yog cov hlab ntsha me hauv lub hlwb, raum, ntsws, thiab tawv nqaij. Cov cim thiab tsos mob ntawm txoj hlab ntshav loj B-cell lymphoma tshwm sim los ntawm cov hlab ntshav sim. Nws kuj tseem hu ua intravascular lymphomatosis.

• Burkitt lymphoma.Burkitt lymphoma yog hom B-cell tsis-Hodgkin lymphoma uas loj thiab kis tawm sai heev. Nws yuav cuam tshuam rau lub puab tsaig, cov pob txha ntawm lub ntsej muag, plab hnyuv, raum, zes qe menyuam, lossis lwm yam kabmob. Muaj peb hom tseem ceeb ntawm Burkitt lymphoma (teb, ntu, thiab txhaj tshuaj tiv thaiv kab mob). Feem ntau qhov mob ntsws Burkitt lymphoma feem ntau tshwm sim hauv Africa thiab txuas rau tus kab mob Epstein-Barr, thiab tawm tsam Burkitt lymphoma tshwm sim thoob plaws ntiaj teb. Kev txhaj tshuaj tiv thaiv kab mob Burkitt lymphoma feem ntau pom nyob hauv cov neeg mob uas mob AIDS. Burkitt lymphoma tuaj yeem kis mus rau lub hlwb thiab tus txha caj qaum thiab kev kho mob kom tiv thaiv nws txoj kev sib kis tau. Burkitt lymphoma tshwm sim feem ntau rau cov menyuam yaus thiab cov neeg laus (Saib cov ntsiab lus hais txog Kev Menyuam Tsis Yog Hodgkin Lymphoma Kev Kho Mob rau cov lus qhia ntxiv.) Burkitt lymphoma tseem hu ua diffuse me me tsis mob hlwb-cell lymphoma.

• Lymphoblastic cov lymphoma. Lymphoblastic lymphoma yuav pib hauv T cell lossis B cell, tab sis feem ntau nws pib hauv T cell. Hom ntshav tsis mob Hodgkin lymphoma, muaj ntau cov qog ntshav (cov qe ntshav tsis paub ntshav) hauv cov qog ntshav thiab lub qog ua kua. Cov lymphoblasts no kis tau rau lwm qhov hauv lub cev, xws li mob hlwb pob txha, hlwb, thiab leeg txha caj qaum. Lymphoblastic lymphoma feem ntau yog rau cov hluas thiab cov neeg laus. Nws yog ntau yam xws li mob ntshav thiav nrog lub cev (cov lymphoblasts feem ntau pom muaj hauv cov leeg pob txha thiab ntshav). (Saib cov ntsiab lus ntawm Kev Kho Tus Mob Loj Hlawv Mob Ntshav Qab Zib Kom Zoo rau cov lus qhia ntxiv.)

• Cov Neeg Laus T-cell mob ntshav daj / mob qog ua ntshav. Cov neeg laus mob T-cell mob ntshav qab zib / mob qog ua kua los ntawm tib neeg T-cell leukemia hom kab mob 1 (HTLV-1). Cov phiajcim suav nrog pob txha thiab tawv nqaij, ntshav tso ntshav calcium ntau ntau, thiab cov qog ntshav, qog ntshav, thiab lub siab uas loj dua li ib txwm.

• Mantle cell lymphoma. Mantle cell lymphoma yog hom B-cell tsis-Hodgkin lymphoma uas feem ntau tshwm sim hauv cov neeg laus nruab nrab lossis laus dua. Nws pib hauv cov qog ntshav thiab kis mus rau tus po, mob pob txha, ntshav, thiab qee zaum txoj hlab pas, plab thiab hnyuv. Cov neeg mob mantle cell lymphoma muaj protein ntau dhau lawm hu ua cyclin-D1 lossis qee yam hloov pauv muaj cov qe ntshav hauv cov lymphoma. Hauv qee tus neeg mob uas tsis muaj cov cim lossis cov tsos mob ntawm lub lymphoma ncua sijhawm pib ntawm kev kho mob tsis cuam tshuam qhov kwv yees.

• Posttransplantation lymphoproliferative teeb meem no. Tus kab mob no tshwm sim rau cov neeg mob uas muaj lub plawv, lub ntsws, lub siab, lub raum, lossis mob hlab ntsha hlwb thiab xav tau kev kho lub neej kom tsis tu ncua. Yuav luag txhua qhov teeb meem posttransplant lymphoproliferative cuam tshuam rau cov cell B thiab muaj tus kab mob Epstein-Barr hauv cov hlwb. Lymphoproliferative ntshawv siab feem ntau kho mob cancer.

• Muaj tseeb histiocytic lymphoma. Qhov no yog hom qog ntshav uas tsis tshua pom muaj, thiab muaj kev ua qog ntau. Kuj tsis paub meej tias nws pib hauv B cell lossis T cell. Nws tsis teb zoo rau kev kho mob nrog cov txheej txheem tshuaj lom neeg.

• Thawj effusion lymphoma. Thawj cov kab mob qog ua ntshav pib rau hauv B cov hlwb uas pom nyob rau thaj chaw uas muaj kua dej ntau, xws li thaj chaw nruab nrab hauv ob sab phlu ntawm lub ntsws thiab lub hauv siab phab ntsa (pleural effusion), lub hnab nyob ib ncig ntawm lub plawv thiab lub plawv (pericardial effusion), lossis hauv plab zom plab plab. Feem ntau tsis muaj qhov hlav uas tuaj yeem pom. Hom qog no feem ntau tshwm sim hauv cov neeg mob uas mob HIV.

• Plasmablastic lymphoma. Plasmablastic lymphoma yog ib hom loj-B-cell tsis-Hodgkin lymphoma uas ua nruj heev. Nws yog feem ntau pom nyob rau hauv cov neeg mob uas muaj tus kab mob HIV.

Cov hnub nyoog laus dua, ua txiv neej, thiab lub cev tsis muaj zog tiv thaiv kab mob tuaj yeem ua rau muaj kev pheej hmoo rau cov neeg laus tsis mob Hodgkin lymphoma.

Txhua yam uas ua rau koj muaj feem yuav kis tus mob yog hu ua kev pheej hmoo. Muaj qhov muaj feem yuav tsis txhais tau tias koj yuav muaj mob qog noj ntshav; tsis muaj yam txaus ntshai tsis txhais tau tias koj yuav tsis muaj mob qog noj ntshav. Tham nrog koj tus kws kho mob yog koj xav tias koj yuav muaj kev pheej hmoo.

Cov no thiab lwm yam kev pheej hmoo yuav ua rau muaj kev pheej hmoo ntawm qee yam ntawm cov neeg laus tsis-Hodgkin lymphoma:

• Ua neeg laus, pojniam, lossis tawv dawb.

• Muaj ib qho ntawm cov kev mob hauv qab no uas ua rau lub cev tsis muaj zog:

• Cov kab mob tiv thaiv kab mob (xws li hypogammaglobulinemia los yog Wiskott-Aldrich syndrome).

• Tus kab mob autoimmune (xws li mob caj dab, mob psoriasis, lossis Sjögren syndrome).

• HIV / AIDS.

• Tib neeg hom T-lymphotrophic virus type I lossis Epstein-Barr kis mob.

• Helicobacter pylori mob.

• Noj tshuaj tiv thaiv kab mob tom qab hloov khoom nruab nrog cev.

Cov tsos mob thiab cov tsos mob ntawm cov neeg laus tsis-Hodgkin lymphoma suav nrog cov qog ntshav o, ua npaws, tawm hws hmo ntuj, yuag, thiab qaug zog.

Cov cim thiab tsos mob no tuaj yeem yog ua rau cov laus tsis mob Hodgkin lymphoma lossis lwm yam mob. Nug koj tus kws kho mob yog tias koj muaj qee yam hauv qab no:

• O ua rau cov qog ntshav hauv lub caj dab, underarm, puab tais, lossis plab.

• Ua npaws yam tsis paub tias yog vim li cas.

• Hmo ntuj tawm hws.

• Zoo nkaus li nkees.

• Poob phaus yam tsis paub tias yog vim li cas.

• Cov tawv nqaij ua pob khaus lossis ua pob khaus.

• Mob hauv siab, plab, lossis pob txha tsis paub vim li cas.

• Thaum kub taub hau, tawm hws ua hmo ntuj, thiab ua kom poob phaus tshwm sim ua ke, pawg mob ntawm pawg no yog hu ua tsos mob B.

Lwm yam cim thiab tsos mob ntawm tus neeg laus tsis-Hodgkin lymphoma tuaj yeem tshwm sim thiab nyob ntawm cov hauv qab no:

• Qhov twg mob cancer hauv lub cev.

• Qhov loj ntawm lub qog.

• Yuav sai npaum li cas cov qog hlob tuaj.

Kev ntsuam xyuas uas kuaj cov lymph system thiab lwm qhov hauv lub cev tau siv los pab kuaj thiab theem cov neeg laus tsis-Hodgkin lymphoma.

Cov ntawv xeem thiab txheej txheem hauv qab no yuav raug siv:

• Kev kuaj mob lub cev thiab keeb kwm kev noj qab haus huv: Kev kuaj lub cev kom kuaj xyuas cov cim ntawm kev noj qab haus huv, suav nrog kuaj lub cim ntawm tus kab mob, xws li cov qog lossis lwm yam uas zoo li txawv txawv. Keeb kwm ntawm tus neeg mob noj qab haus huv, suav nrog kev kub taub hau, tawm hws hmo ntuj, thiab poob phaus, kev noj qab haus huv, thiab yav dhau los kev mob nkeeg thiab kev kho yuav tseem yuav ua.

• Ua kom tiav cov ntshav suav (CBC): Tus txheej txheem uas coj cov ntshav mus kuaj thiab kuaj rau cov hauv qab no:

• Tus naj npawb ntawm cov qe ntshav liab, cov qe ntshav dawb thiab cov qe ntshav.

• Cov ntshav hemoglobin (cov protein uas nqa oxygen) hauv cov ntshav liab.

• Feem ntawm cov qauv ua los ntawm cov ntshav liab.

Ua kom tiav cov ntshav suav (CBC). Ntshav yog sau los ntawm kev ntxig ib rab koob rau hauv cov leeg thiab pub cov ntshav tuaj rau hauv lub raj. Cov ntshav ntsuas raug xa mus rau chav kuaj thiab ntshav liab, ntshav dawb, thiab cov ntshav khov yog suav. Lub CBC yog siv los ntsuas rau, ntsuas mob, thiab saib xyuas ntau yam mob.

• Kev tshawb fawb hauv ntshav cov ntshav: Tus txheej txheem tso ntshav kuaj ntsuas los ntsuas cov khoom tshuaj uas tso rau hauv ntshav los ntawm cov plab hnyuv siab raum thiab cov nqaij hauv lub cev. Ib qho txawv (ntau dua lossis qis dua qub) ntawm cov tshuaj yuav ua rau lub cim ntawm tus kabmob.

• Kev kuaj ntshav LDH: Ib txoj kev kuaj ntshav kuaj cov ntshav lactic dehydrogenase kom tsawg. Kev nce ntxiv ntawm LDH hauv cov ntshav tuaj yeem yog qhov cim ntawm kev puas tsuaj ntawm cov nqaij mos, nqaij hlav, lossis lwm yam mob.

• Kuaj mob rau daim siab B thiab kab mob siab C: Tus txheej txheem uas kuaj cov ntshav ntsuas tus kab mob siab B tiv thaiv antigens thiab / lossis tshuaj tiv thaiv kab mob thiab cov tshuaj tiv thaiv kab mob siab hom C. Cov antigens lossis tshuaj tiv thaiv kab mob hu ua cov cim. Cov cim sau sib txawv lossis cov cim cim sib xyaw tau siv los txiav txim siab seb tus neeg mob puas muaj kab mob siab B lossis C, tau muaj kev kis ua ntej lossis txhaj tshuaj, lossis muaj kev kis mob yooj yim. Cov neeg mob uas tau txais kev kho tus kab mob siab B yav dhau los yuav tsum tau soj ntsuam ntxiv kom paub seb nws puas rov mob ntxiv. Paub tias ib tug neeg muaj kab mob siab B lossis C puas tuaj yeem pab npaj kho.

• Kev kuaj HIV: Kev ntsuas ntsuas los ntsuas theem ntawm cov tshuaj tiv thaiv HIV rau hauv tus qauv ntsuas ntshav. Cov tshuaj tua kab mob yog tsim los ntawm lub cev thaum nws txeeb los ntawm cov tshuaj txawv teb chaws. Theem tiv thaiv cov kab mob HIV ntau dua tej zaum txhais tau tias lub cev muaj tus kabmob HIV.

• CT scan (CAT scan): Cov txheej txheem uas ua rau cov duab ntxaws ntxig ntawm cov chaw hauv lub cev, xws li caj dab, hauv siab, plab, pelvis, thiab cov qog ntshav, coj los ntawm ntau cov ces kaum. Cov duab no yog tsim los ntawm lub koos pis tawj txuas nrog lub tshuab xoo hluav taws xob. Ib qho zas xim tuaj yeem raug txhaj rau hauv txoj hlab ntshav lossis nqos los pab rau cov kabmob lossis cov nqaij ua kom pom tseeb dua. Cov txheej txheem no tseem hu ua suav tomography, computer tom tomography, lossis computerized axial tomography.

• PET scan (positron emission tomography scan): Tus txheej txheem los nrhiav cov qog ua qog ntshav hauv lub cev. Ib qho me me ntawm cov kua hluav taws xob cov kua qab zib (qab zib) tau txhaj rau txoj hlab ntshav. PET scanner tig ncig lub cev thiab ua ib daim duab ntawm qhov chaw nyob hauv qab ntawm lub cev tau siv. Malignant qog hlwb nthuav qhia lub ci nyob hauv daim duab vim tias lawv nquag tshaj thiab noj ntau dua cov piam thaj dua li cov hlwb ua.

• Nqaij pob txha mos thiab xyoob ntoo: Kev tshem tawm ntawm cov pob txha thiab pob txha me me los ntawm kev ntxig ib rab koob mus rau ntawm lub duav lossis ob lub mis. Tus kws kho mob hais txog pob txha caj qaum thiab pob txha nyob hauv lub tshuab tsom seb puas pom cov cim mob qog nqaij hlav.

Nqaij pob txha txhaws thiab nqus xyoob. Tom qab qhov chaw me me ntawm daim tawv nqaij loog, pob txha pob txha koob tau ntxig rau hauv tus neeg mob lub pob txha txha. Cov hnoos qeev ntshav, pob txha, thiab pob txha pob txha tau raug tshem tawm mus kuaj hauv lub tshuab tsom.

• Lymph node biopsy: Qhov tshem tawm tag nrho lossis ib feem ntawm cov qog ntshav. Tus kws kho mob tshawb pom cov nqaij hauv qab lub tshuab tsom rau cov kab mob qog noj ntshav. Ib qho ntawm cov hauv qab no tso tawm tuaj yeem ua:

• Kev phais me me: Qhov tshem tawm tag nrho cov qog ntshav.

• Kev phais me me: Qhov tshem tawm ntawm ib feem ntawm cov qog ntshav.

• Cov tub ntxhais muab tso tawm: tshem tawm ntawm ib feem ntawm cov qog siv siv rab koob loj.

Yog tias pom muaj mob qog noj ntshav, yuav tshuaj ntsuam cov kab hauv qab no los saib cov qog nqaij hlav cancer:

• Immunohistochemistry: Kev sim tshuaj uas siv tshuaj tiv thaiv kab mob los tiv thaiv qee yam antigens (ntaus cim) hauv cov qauv ntawm tus neeg mob lub cev. Cov tshuaj tiv thaiv kab mob feem ntau yog txuas nrog qhov enzyme lossis fluorescent zas. Tom qab cov tshuaj tiv thaiv txuas mus rau ib qho antigen tshwj xeeb hauv cov qauv ntaub so ntswg, cov enzyme lossis zas xim raug qhib, thiab cov antigen tuaj yeem pom hauv qab lub tshuab tsom. Kev kuaj ntshav no siv los pab kuaj mob qog nqaij hlav thiab pab qhia ib hom qog ntshav los ntawm lwm hom mob qog noj ntshav.

• Kev tshuaj ntsuam Cytogenetic: Kev sim tshuaj uas cov chromosomes ntawm cov hlwb hauv ib qho qauv ntawm cov ntshav lossis pob txha txhawm rau suav thiab txheeb xyuas rau txhua qhov hloov pauv, xws li tawg, ploj, rov kho dua, lossis ntxiv rau cov xoos xoos. Kev hloov qee yam chromosomes yuav yog mob qog nqaij hlav. Cytogenetic tsom xam yog siv los pab ntsuas mob qog noj ntshav, npaj kev kho mob, lossis pom tias kev kho mob ua haujlwm tau zoo npaum li cas.

• Immunophenotyping: Kev sim tshuaj uas siv tshuaj tiv thaiv kab mob ntawm cov qog nqaij hlav cancer ua raws li hom antigens lossis cim rau ntawm cov kem hlwb. Qhov kev ntsuam xyuas no yog siv los pab txheeb xyuas qee hom qog ntshav.

• FISH (fluorescence hauv situ hybridization): Lub chaw sim siv los saib thiab suav cov noob lossis cov keeb yoog nyob hauv cov hlwb thiab cov ntaub so ntswg. Cov qog ntawm DNA uas muaj cov xim fluorescent yog tsim nyob rau hauv chav kuaj thiab ntxiv rau ib qho qauv ntawm tus neeg mob lub hlwb lossis cov nqaij. Thaum cov dyed pieces ntawm DNA txuas rau qee cov caj ces lossis thaj chaw ntawm cov chromosomes hauv qhov qauv, lawv taws thaum saib hauv qab lub tshuab tsom fluorescent. Kev ntsuas FISH yog siv los pab ntsuas mob qog nqaij hlav thiab pab npaj kho mob.

Lwm yam kev kuaj thiab txheej txheem yuav ua tau raws li cov cim qhia thiab cov tsos mob uas pom thiab qhov twg mob cancer hauv lub cev.

Qee yam cuam tshuam txog kev raug (mob rov qab) thiab txoj kev kho.

Qhov raug thiab kho kev xaiv nyob ntawm cov hauv qab no:

• Tus neeg mob cov cim thiab cov tsos mob, suav nrog seb lawv puas muaj cim B (kub taub hau vim tsis paub meej, poob phaus yam tsis paub tias yog vim li cas, lossis tawm hws hmo ntuj).

• Cov theem ntawm tus kabmob (qhov luaj li cas mob qog thiab seb mob cancer puas kis mus rau lwm qhov hauv lub cev lossis mob qog).

• Hom tsis-Hodgkin lymphoma.

• Qhov ntau npaum li cas ntawm cov lactate dehydrogenase (LDH) hauv cov ntshav.

• Txawm hais tias muaj qee yam hloov pauv ntawm cov caj ces.

• Tus neeg mob lub hnub nyoog, poj niam txiv neej, thiab kev noj qab haus huv ib txwm muaj.

• Seb puas yog cov mob qog noj ntshav tau nyuam qhuav raug sim, txuas ntxiv zuj zus thaum kho, lossis tau rov muaj mob (rov qab los).

Txog qhov tsis yog Hodgkin lymphoma thaum cev xeeb tub, cov kev xaiv kho kuj yog nyob ntawm:

• Kev xav tau ntawm tus neeg mob.

• Lub hlis twg ntawm cev xeeb tub tus neeg mob nyob hauv.

• Seb tus menyuam puas tuaj yeem xa menyuam ntxov.

Qee hom mob uas tsis yog Hodgkin lymphoma kis tau sai dua li lwm tus. Feem ntau tsis yog Hodgkin lymphomas uas tshwm sim thaum cev xeeb tub yog txhoj puab heev. Ncua kev kho tus mob qog kom txog thaum tom qab yug tau tus me nyuam tag yuav ua rau niam menyuam muaj feem nyob ntev dua. Kev kho mob sai yog feem ntau pom zoo, txawm tias thaum cev xeeb tub.

Cov theem ntawm Cov Neeg Loj Tsis-Hodgkin Lymphoma

QHOV TSEEM CEEB

• Tom qab cov neeg laus tsis-Hodgkin lymphoma tau kuaj pom, ua tiav kev ntsuam xyuas kom paub seb puas muaj cov kab mob kheesxaws kis tau rau hauv lub lymph lossis mus rau lwm qhov hauv lub cev.

• Muaj peb txoj hauv kev uas mob cancer kis hauv lub cev.

• Cov theem hauv qab no yog siv rau cov neeg laus tsis mob Hodgkin lymphoma:

• Theem Kuv

• Theem II

• Theem III

• Theem IV

• Recurrent Cov Neeg laus Tsis-Hodgkin Lymphoma

• Cov neeg laus uas tsis yog Hodgkin lymphomas yuav muab cais ua pawg kho kom raws li tus kabmob kheesxaws lossis mob hnyav, seb puas muaj cov qog ntshav nyob ntawm ib sab ntawm lub cev, thiab saib tus kabmob puas tau nyuam qhuav raug kuaj lossis rov ua dua.

Tom qab cov neeg laus tsis-Hodgkin lymphoma tau kuaj pom, ua tiav kev ntsuam xyuas kom paub seb puas muaj cov kab mob kheesxaws kis tau rau hauv lub lymph lossis mus rau lwm qhov hauv lub cev.

Cov txheej txheem tau siv los tshawb pom hom mob qog nqaij hlav thiab yog tias cov qog nqaij hlav cancer tau kis mus rau hauv cov lymph lossis lwm qhov hauv lub cev hu ua staging. Cov ntaub ntawv sau los ntawm cov txheej txheem theem txiav txim theem ntawm tus kab mob. Nws yog ib qho tseem ceeb kom paub theem ntawm tus kab mob thiaj li npaj tau kev kho mob. Cov txiaj ntsig ntawm kev tshuaj ntsuam thiab cov txheej txheem ua tiav rau kev kuaj mob uas tsis yog Hodgkin lymphoma yog siv los pab txiav txim siab txog kev kho mob.

Cov ntawv xeem txuas mus ntxiv no thiab cov txheej txheem hauv qab no kuj tseem siv tau rau hauv cov txheej txheem kev tswj hwm:

• MRI (sib nqus resonance duab) nrog gadolinium: tus txheej txheem uas siv cov hlau nplaum, xov tooj cua voos, thiab lub koos pij tawj los ua cov duab ntawm cov ncauj lus kom ntxaws ntawm thaj chaw hauv lub cev, xws li lub hlwb thiab tus txha caj qaum. Cov tshuaj hu ua gadolinium raug txhaj rau hauv tus neeg mob hla ntawm txoj hlab ntsha. Tus gadolinium sau ib puag ncig cov qog nqaij hlav cancer thiaj li ua rau lawv pom ci ntsa iab hauv daim duab. Tus txheej txheem no tseem hu ua nuclear sib nqus resonance imaging (NMRI).

• Lumbar puncture: Tus txheej txheem siv los sau cov kua roj cerebrospinal kua (CSF) los ntawm pob txha caj qaum. Qhov no yog ua los ntawm kev tso ib rab koob ntawm ob pob txha hauv tus nqaj qaum thiab nkag rau hauv CSF puag ncig tus txha nraub qaum thiab hle qhov hnoos qeev. Qhov piv txwv ntawm CSF raug kuaj hauv qab lub tshuab tsom rau cov cim qhia tias tus kabmob tau kis mus rau lub hlwb thiab tus txha caj qaum. Qhov txheej txheem no tseem hu ua LP lossis txha caj qaum.

Lumbar puncture. Tus neeg mob pw hauv ib qho chaw curled ntawm lub rooj. Tom qab thaj chaw me me ntawm sab nraub qaum yog numbed, koob koob txha nqaj (ntev dua, nyias koob) tau ntxig rau hauv qhov qis ntawm qhov txha caj qaum kom tshem tawm cov cerebrospinal kua (CSF, qhia hauv xiav). Cov kua dej yuav xa mus rau qhov chaw kuaj sim.

Rau cov poj niam cev xeeb tub uas tsis mob Hodgkin lymphoma, kev kuaj kab mob kev sib tw thiab cov txheej txheem uas tiv thaiv tus me nyuam hauv plab los ntawm kev puas tsuaj ntawm hluav taws xob tau siv. Cov kev kuaj thiab cov txheej txheem no suav nrog MRI (yam tsis muaj qhov tsis sib thooj), tus caj pas mob ntsws, thiab ultrasound.

Muaj peb txoj hauv kev uas mob cancer kis hauv lub cev. Kab mob khees xaws tuaj yeem kis tawm los ntawm cov nqaij mos, cov qog ntshav, thiab ntshav:

• Ntaub so ntswg. Tus kab mob cancer kis los ntawm qhov chaw nws pib kis los ntawm thaj chaw ze.

• Lymph system. Tus mob cancer kis ntawm qhov uas nws pib los ntawm kev nkag rau hauv lymph system. Tus kab mob cancer taug kev los ntawm cov qog ntshav mus rau lwm qhov ntawm lub cev.

• Ntshav. Tus mob cancer kis rau nws los ntawm qhov nws pib los ntawm nkag rau hauv cov ntshav. Tus kabmob khiav tawm hauv cov hlab ntshav mus rau lwm qhov ntawm lub cev.

Cov theem hauv qab no yog siv rau cov neeg laus tsis mob Hodgkin lymphoma:

Theem Kuv

Theem Kuv loj hlob ntawm cov qog ntshav. Cov kab mob khees xaws muaj nyob hauv ib lossis ntau lub qog ua haujlwm nyob rau hauv ib pawg ntawm cov qog ntshav lossis, hauv qee kis, mob qog nqaij hlav nyob hauv Waldeyer lub nplhaib, thymus, lossis tus po. Hauv theem IE (tsis pom tias), mob cancer tau kis rau ib thaj chaw sab nraud lymph kab mob.

Cov theem I neeg laus tsis-Hodgkin lymphoma tau muab faib ua theem I thiab IE.

Hauv theem I, kev mob qog yog pom nyob rau ib qho ntawm cov chaw hauv qab ntawm cov qog ntshav:

• Ib lossis ntau dua cov qog ua ib pawg ntawm cov qog ntshav.

• Waldeyer lub nplhaib.

• Thymus.

• Spleen.

Hauv theem IE, mob khees-xaws muaj nyob rau ib thaj chaw sab nraud lymph system.

Theem II

Theem II tus neeg laus tsis-Hodgkin lymphoma tau muab faib ua ntu II thiab IIE.

• Hauv theem II, mob qog nqaij hlav tau pom nyob hauv ob lossis ntau pawg lymph node uas yog saum toj ntawm lub diaphragm lossis hauv qab daim diaphragm.

Theem II cov laus mob qog ua ntshav. Cov kab mob kheesxaws tau pom nyob hauv ob lossis ntau pawg lymph node uas yog saum toj ntawm lub diaphragm lossis qis dua ntawm lub diaphragm.

• Hauv Ntu IIE, mob qog nqaij hlav tau kis mob los ntawm ib pawg ntawm cov qog ntshav mus rau qhov chaw ze uas nyob sab nraum lymph lymph. Mob kheesxaws yuav kis mus rau lwm cov lymph node pawg nyob rau tib sab ntawm lub diaphragm.

Theem IIE cov laus mob qog ua ntshav. Cov kabmob kheesxaws tau kis tawm ntawm ib pawg ntawm cov qog ntshav mus rau thaj chaw ze uas nyob sab nraud cov qog ntshav. Mob kheesxaws yuav kis mus rau lwm cov lymph node pawg nyob rau tib sab ntawm lub diaphragm.

Hauv theem II, lo lus tua kabmob loj yog hais txog tus kabmob loj dua. Qhov loj ntawm qog loj uas tau hais txog kev tua kabmob ua haujlwm sib txawv raws li hom qog.

Theem III

Theem III cov laus lymphoma. Cov kab mob khees xaws muaj nyob hauv pawg ntawm cov qog ntshav ntawm ob qho saum toj thiab hauv qab daim diaphragm; lossis hauv pawg qog ua kua saum lub diaphragm thiab hauv qhov hnoos qeev.

Hauv theem III neeg laus tsis-Hodgkin lymphoma, mob cancer yog pom:

• hauv ib pawg ntawm cov qog ntshav ntawm ob qho saum toj thiab hauv qab ntawm lub diaphragm; lossis

• hauv cov qog ntshav saum lub diaphragm thiab hauv qhov hnoos qeev.

Theem IV

Theem IV neeg laus qog ntshav. Mob Cancer (a) tau kis thoob ib lossis ntau qhov kabmob sab nraud cov lymph; los yog (b) nyob hauv ob lossis ntau pawg neeg muaj cov lymph nodes uas yog saum toj ntawm lub diaphragm lossis qis dua ntawm lub diaphragm thiab hauv ib qho hloov khoom nruab nrog sab nraud ntawm lymph system thiab tsis nyob ze rau cov qog ntshav tawm; los yog (c) nyob hauv cov qog ntshav siab dua qhov diaphragm thiab hauv qab ntawm daim diaphragm thiab hauv ib qho khoom nrog tawm sab nraum lymph system; los yog (d) yog pom nyob hauv lub siab, mob pob txha, ntau dua ib qho chaw hauv lub ntsws, lossis kua dej cerebrospinal (CSF). Cov kabmob tsis kis mus rau lub siab, mob pob txha, mob ntsws, lossis CSF los ntawm cov qog ntshav nyob ze.

Hauv theem IV neeg laus-Hodgkin lymphoma, mob cancer:

• tau kis thoob plaws ib lossis ntau qhov chaw hauv nruab nrog sab nraud lub lymph; lossis

• yog pom nyob hauv ob lossis ntau pawg neeg muaj cov lymph nodes uas yog saum toj ntawm lub diaphragm lossis qis dua ntawm lub diaphragm thiab hauv ib qho hloov khoom nruab nrog sab nraud lymph system thiab tsis nyob ze rau cov qog ntshav tawm; lossis

• muaj nyob hauv cov pab pawg ntawm cov qog ntshav ntawm ob qho saum toj thiab hauv qab daim diaphragm thiab hauv ib qho khoom hauv nrog sab nraum lub lymph leeg; lossis

• yog pom nyob hauv daim siab, mob pob txha, ntau qhov chaw nyob hauv lub ntsws, lossis kua dej cerebrospinal (CSF). Cov kabmob tsis kis mus rau lub siab, mob pob txha, mob ntsws, lossis CSF los ntawm cov qog ntshav nyob ze.

Recurrent Cov Neeg laus Tsis-Hodgkin Lymphoma

Cov neeg laus uas tsis yog Hodgkin lymphoma yog cov mob cancer uas tau rov mob dua (rov qab los) tom qab nws tau raug kho. Lub lymphoma yuav rov qab los hauv lub lymph system lossis hauv lwm qhov chaw ntawm lub cev. Indolent lymphoma tuaj yeem rov qab los ua mob qog nqaij hlav. Cov mob qog ua kua hlav tuaj yeem rov qab los zoo li mob qog ua kua qaub.

Cov neeg laus uas tsis yog Hodgkin lymphomas yuav muab cais ua pawg kho kom raws li tus kabmob kheesxaws lossis mob hnyav, seb puas muaj cov qog ntshav nyob ntawm ib sab ntawm lub cev, thiab saib tus kabmob puas tau nyuam qhuav raug kuaj lossis rov ua dua.

Saib tshooj General Cov Lus Qhia rau cov lus qhia ntau ntxiv txog cov hom tsis tuaj yeem (maj mam-loj hlob) thiab hnyav (loj hlob sai) tsis-Hodgkin lymphoma.

Tsis-Hodgkin lymphoma tuaj yeem piav tau tias yog sib kis lossis tsis txuas:

• Cov mob lymphomas: Cov qog ntshav uas cov qog ntshav nrog qog noj ntshav nyob ib sab.

• Tsis mob dabtsi: Cov qog ntshav uas cov qog ntshav nrog qog tsis nyob ib sab, tab sis nyob ntawm tib sab ntawm lub diaphragm.

Txoj Kev Kho Mob Cov Tswv Yim

QHOV TSEEM CEEB

• Muaj ntau hom kev kho mob rau cov neeg mob uas tsis-Hodgkin lymphoma.

• Cov neeg mob uas tsis yog Hodgkin lymphoma yuav tsum muaj lawv cov kev kho mob npaj los ntawm pab pawg ntawm cov neeg saib xyuas kev noj qab haus huv uas yog cov kws tshaj lij hauv kev kho mob

• lymphomas.

• Kev kho mob rau cov neeg laus tsis mob Hodgkin lymphoma tuaj yeem ua rau muaj kev phiv tshuaj.

• Kev siv hluav taws xob

• Kws khomob

• Kev Txhaj Tshuaj Tiv Thaiv

• Cov hom phiaj kho

• Plasmapheresis

• Xyuam xim tos

• Tshuaj tua kab mob kho

• Kev phais mob

• Qia cell hloov

• Cov hom kev kho mob tshiab tau raug sim hauv qhov kev sim kho mob.

• Tshuaj kho tiv thaiv

• Cov neeg mob yuav xav txog kev sim kho mob.

• Cov neeg mob tuaj yeem nkag mus kuaj mob ua ntej, sijhawm, lossis tom qab pib kho mob qog noj ntshav.

• Tej zaum yuav tau ua raws li kev ntsuam xyuas.

Muaj ntau hom kev kho mob rau cov neeg mob uas tsis-Hodgkin lymphoma.

Ntau hom kev kho mob muaj rau cov neeg mob uas tsis-Hodgkin lymphoma. Qee qhov kev kho mob yog tus qauv (cov kev kho mob tam sim no), thiab qee qhov raug sim hauv kev kuaj mob. Kev kho mob hauv tsev kho mob yog txoj kev tshawb nrhiav uas pab txhawm rau txhim kho kev kho mob tam sim no lossis tau txais cov ntaub ntawv ntawm kev kho mob tshiab rau cov neeg mob cancer. Thaum kuaj pom tias cov kev kho tshiab zoo dua li kev kho mob, cov kev kho mob tshiab tuaj yeem dhau los ua cov qauv kev kho mob. Cov neeg mob yuav xav txog kev sim kho mob. Qee qhov kev sim tshuaj sim tsuas yog qhib rau cov neeg mob uas tsis tau pib kho.

Rau cov poj niam cev xeeb tub nrog tsis mob Hodgkin lymphoma, txoj kev kho yog ua tib zoo xaiv los tiv thaiv tus menyuam hauv plab. Qhov kev txiav txim siab kho yog nyob ntawm leej niam txoj kev xav, theem ntawm tsis mob Hodgkin lymphoma, thiab lub hnub nyoog ntawm tus menyuam tsis tau yug. Cov phiaj xwm kho mob yuav pauv raws li tus cim thiab tsos mob, mob qog noj ntshav, thiab cev xeeb tub. Xaiv cov kev kho mob cancer uas tsim nyog tshaj plaws yog kev txiav txim siab uas yog koom nrog tus neeg mob, tsev neeg, thiab pab pawg kho mob.

Cov neeg mob uas tsis yog Hodgkin lymphoma yuav tsum muaj lawv cov kev kho mob npaj los ntawm ib pab pawg kws saib xyuas kev noj qab haus huv uas yog cov kws tshaj lij hauv kev kho cov mob lymphomas.

Kev kho yuav yog saib xyuas los ntawm tus kws kho mob oncologist, tus kws kho mob hauv kev kho mob qog noj ntshav, lossis hematologist, kws kho mob uas paub txog kev kho mob qog ntshav. Tus kws kho mob paub yuav xa koj mus rau lwm tus kws saib xyuas kev noj qab haus huv uas muaj kev paub dhau los thiab yog tus kws tshaj lij hauv kev kho cov neeg laus uas tsis yog Hodgkin lymphoma thiab tus uas paub tshwj xeeb hauv qee yam tshuaj. Cov no yuav suav nrog cov kws tshwj xeeb hauv qab no:

• Neurosurgeon.

• Neurologist.

• Kws phais hluav taws xob oncologist.

• Endocrinologist.

• Cov kws tshaj lij fab kev peem tsheej.

• Lwm cov kws tshaj lij oncology.

Kev kho mob rau cov neeg laus tsis mob Hodgkin lymphoma tuaj yeem ua rau muaj kev phiv tshuaj.

Yog xav paub txog cov kev mob tshwm sim uas pib thaum kho mob cancer, mus saib peb Nplooj Ntawv Sab Npab.

Cov kev mob tshwm sim los ntawm kev kho mob cancer uas pib tom qab kho thiab txuas ntxiv rau lub hlis lossis xyoo yog hu ua kev mob lig. Kev kho nrog kev siv tshuaj kho mob, siv tshuaj kho hluav taws xob, lossis qia hloov qog rau qhov tsis mob Hodgkin lymphoma tuaj yeem ua rau muaj kev pheej hmoo ntawm cov mob lig.

Kev lig dhau los ntawm kev kho mob cancer tej zaum yuav muaj cov hauv qab no:

• Lub plawv muaj teeb meem.

• Ntxiv lawm tshob (tsis muaj menyuam).

• Ua rau pob txha tsis sib haum.

• Neuropathy (puas hlwb puas uas ua rau tsis hnov ​​lus lossis taug kev nyuaj).

• Kab mob cancer thib ob, xws li:

• Mob ntsws cancer.

• Mob hlwb.

• Mob raum.

• Lub zais zis mob hlwb.

• Melanoma.

• Hodgkin lymphoma.

• Myelodysplastic syndrome.

• Mob myeloid caj dab.

Qee qhov cuam tshuam tom qab tuaj yeem kho lossis tswj tau. Nws yog ib qho tseem ceeb nrog kws kho mob tham txog cov kev kho mob cancer tuaj yeem muaj rau koj. Kev rov qab soj ntsuam kom paub qhov ua rau qeeb yog qhov tseem ceeb.

Cuaj hom kev kho mob tau siv:

Kev siv hluav taws xob

Kev xoo hluav taws xob yog kev kho mob cancer uas siv hluav taws xob xoo hluav taws xob loj lossis lwm yam hluav taws xob tua ntau los tua cov qog nqaij hlav cancer lossis ua kom lawv loj tuaj.

Kev siv hluav taws xob sab nraud siv lub tshuab sab nraud lub cev xa cov hluav taws xob mus rau thaj tsam ntawm lub cev nrog mob qog noj ntshav. Qee lub sij hawm tag nrho-lub cev tiv thaiv kab mob raug muab ua ntej hloov qia cell.

Proton beam hluav taws xob kho siv cov kwj ntawm cov protons (cov khoom me me nrog tus nqi them zoo) los tua cov qog ua qog. Hom kev kho mob no tuaj yeem txo qis hluav taws xob ntau npaum li cas rau cov nqaij noj qab haus huv nyob ze lub qog, xws li lub siab lossis lub mis.

Kev kho hluav taws xob sab nraud yog siv los kho tus neeg laus tsis mob Hodgkin lymphoma, thiab kuj tseem yuav raug siv ua palliative kev kho mob kom txo cov tsos mob thiab txhim kho lub neej zoo.

Rau cov poj niam cev xeeb tub nrog tsis-Hodgkin lymphoma, kev kho hluav taws xob yuav tsum tau muab tom qab yug menyuam, yog tias ua tau, kom tsis txhob muaj kev pheej hmoo rau tus menyuam hauv plab. Yog tias xav tau kev kho mob sai sai, tus poj niam yuav txiav txim siab txuas ntxiv cev xeeb tub thiab txais kev kho mob hluav taws xob. Daim iav siv yog siv los npog tus poj niam cev xeeb tub lub plab los pab tiv thaiv tus me nyuam hauv plab los ntawm hluav taws xob ntau li ntau tau.

Kws khomob

Kev siv tshuaj kho mob yog kev kho mob cancer uas siv cov tshuaj los txwv kev loj hlob ntawm cov qog nqaij hlav cancer, los ntawm kev tua cov qog lossis txwv tsis pub faib. Thaum cov tshuaj tua kab mob noj los ntawm qhov ncauj lossis txhaj rau hauv txoj hlab ntshav lossis leeg, cov tshuaj nkag mus rau cov ntshav thiab tuaj yeem mus txog rau cov qog nqaij hlav ntshav thoob plaws lub cev (kev kho mob tshuaj tua kabmob). Thaum cov kws kho mob tso tshuaj ncaj qha rau cov kua tshuaj tua kab mob hlwb (tshuaj pleev ib ce rau ib leeg), ib qho khoom hauv nruab nrog cev, lossis lub cev lub cev xws li lub plab zom mov, cov tshuaj feem ntau cuam tshuam rau cov qog nqaij hlav cancer hauv thaj chaw (thaj av kho mob). Kev siv tshuaj sib xyaw ua ke yog kev kho mob siv ob lossis ntau hom tshuaj anticancer. Cov tshuaj steroid tuaj yeem raug ntxiv, kom txo qis kev mob thiab txo qis hauv lub cev kev ua haujlwm.

Kev siv tshuaj sib xyaw ua ke yog siv rau kev kho mob ntawm cov neeg laus tsis-Hodgkin lymphoma.

Intrathecal kev siv tshuaj kho mob kuj tseem siv tau los kho cov qog ntshav uas ua thawj hauv cov noob qes lossis mob ntshav (qhov chaw mos) nyob ib ncig ntawm lub qhov ntswg, diffuse loj B-cell lymphoma, Burkitt lymphoma, lymphoblastic lymphoma, thiab qee qhov mob T-cell lymphomas. Nws raug muab rau kom muaj qhov pheej hmoo tias cov qog ntshav yuav kis mus rau lub hlwb thiab tus txha nqaj qaum. Qhov no yog hu ua CNS prophylaxis.

Intrathecal kev siv tshuaj kho mob. Cov tshuaj anticancer tau txhaj rau hauv qhov chaw intrathecal, uas yog qhov chaw khaws cov tshuaj cerebrospinal kua (CSF, qhia xiav). Muaj ob txoj hauv kev los ua qhov no. Ib txoj kev, qhia nyob rau sab kawg nkaus ntawm daim duab, yog txhaj cov tshuaj mus rau hauv Ommaya lub taub dej (lub thawv uas muaj cov dome uas tau tso rau hauv tawv taub hau thaum phais mob; nws tuav cov tshuaj thaum lawv ntws los ntawm lub raj me me rau hauv lub hlwb. )). Lwm txoj kev, qhia nyob rau hauv qab seem ntawm daim duab, yog kom txhaj cov tshuaj ncaj qha rau hauv CSF hauv ntu qis ntawm pob txha caj qaum, tom qab thaj chaw me me ntawm sab nraub qaum yog loog.

Thaum tus poj niam cev xeeb tub raug kho nrog kev kho mob rau cov tsis mob Hodgkin lymphoma, tus me nyuam hauv plab tsis tuaj yeem tiv thaiv los ntawm kev siv tshuaj kho mob. Qee cov tshuaj siv tshuaj kho mob yuav ua rau yug tau qhov tsis zoo yog tias muab thawj peb lub hlis.

Saib Cov Tshuaj Pom Zoo rau Kev Tsis-Hodgkin Lymphoma yog xav paub ntxiv.

Kev Txhaj Tshuaj Tiv Thaiv

Kev Siv Tshuaj Tiv Thaiv yog ib txoj kev kho mob uas siv tus neeg mob lub cev tiv thaiv kab mob cancer. Cov tshuaj uas tsim los ntawm lub cev lossis tsim hauv chav siv tshuaj yog siv los txhawb, ncaj qha, lossis rov kho lub cev lub cev los tiv thaiv tus mob qog nqaij hlav. Immunomodulators thiab CAR T-cell kho yog hom kev siv tshuaj tiv thaiv.

• Immunomodulators: Lenalidomide yog immunomodulator siv los kho tus neeg laus tsis mob Hodgkin lymphoma.

• Kev Kho Mob T-cell: Tus neeg mob lub hlwb T (ib hom kab mob tiv thaiv kab mob) raug hloov pauv kom lawv thiaj li tawm tsam qee cov protein nyob rau ntawm qog nqaij hlav cancer. T qog noj tau los ntawm tus neeg mob thiab cov receptors tshwj xeeb ntxiv rau lawv nto nyob hauv chav kuaj. Cov hloov pauv hauv hlwb yog hu ua chimeric antigen receptor (CAR) T cell. Lub hlwb T hlwb raug loj hlob hauv chav kuaj thiab muab rau tus neeg mob los ntawm kev ua txhaum. Cov hlwb T ua rau cov neeg mob cov ntshav ntau ntau thiab tua cov qog nqaij hlav cancer. Kev kho mob T-cell (xws li axicabtagene ciloleucel lossis tisagenlecleucel) yog siv los kho B-cell loj cov qog ntshav uas tsis tau txais kev kho mob.

Kev kho T-cell kho mob. Ib hom kev kho mob uas tus neeg lub hlwb T (ib hom mob tiv thaiv kab mob) tau hloov pauv hauv chav kuaj tshuaj vim li ntawd lawv yuav khi rau cov qog nqaij hlav cancer thiab tua lawv. Cov ntshav los ntawm cov leeg ntshav hauv tus neeg mob txhais caj npab ntws los ntawm lub raj xa mus rau lub tshuab apheresis (tsis qhia tawm), uas tshem tawm cov qe ntshav dawb, suav nrog T cell, thiab xa cov ntshav rov qab rau tus neeg mob. Tom qab ntawd, lub noob rau tshwj xeeb receptor hu ua chim chim antigen receptor (CAR) muab tso rau hauv T cell hauv chav kuaj. Ntau lab ntawm lub hlwb T hlwb raug loj hlob hauv chav kuaj thiab tom qab ntawd muab rau tus neeg mob los ntawm infusion. Cov hlwb T ua ke muaj peev xwm khi rau ib tus antigen ntawm cov kabmob kheesxaws thiab tua lawv.

Saib Cov Tshuaj Pom Zoo rau Kev Tsis-Hodgkin Lymphoma yog xav paub ntxiv.

Cov hom phiaj kho

Cov hom phiaj kho yog ib hom kev kho mob uas siv tshuaj los yog lwm yam tshuaj los txheeb xyuas thiab tua cov qe ntshav tshwj xeeb tsis yog ua mob rau cov leeg zoo li qub. Kev kho mob monoclonal antibody therapy, kev kho mob proteasome inhibitor, thiab kev kho mob kinase inhibitor yog hom kev kho mob hom phiaj siv los kho tus neeg laus tsis mob Hodgkin lymphoma.

Monoclonal antibody therapy yog kev kho mob qog noj ntshav uas siv cov tshuaj pleev rau hauv qhov chaw kuaj kab mob los ntawm ib hom kab mob tiv thaiv kab mob ntawm tes. Cov tshuaj tiv thaiv no tuaj yeem txheeb xyuas cov tshuaj ntawm qog nqaij hlav cancer lossis cov khoom qub uas tuaj yeem pab ua kom cov cell mob qog noj ntshav. Cov tshuaj tiv thaiv txuas rau cov tshuaj thiab tua cov qog nqaij hlav cancer, thaiv lawv qhov kev loj hlob, lossis txwv tsis pub kis mus rau lwm qhov. Lawv yuav raug siv nyob ib leeg lossis nqa tshuaj, co toxins, lossis khoom siv hluav taws xob ncaj qha mus rau qog nqaij hlav cancer. Cov kab mob monoclonal yog muab los ntawm kev lis ntshav.

Hom kab mob monoclonal muaj xws li:

• Rituximab, siv los kho ntau yam mob tsis-Hodgkin lymphoma.

• Obinutuzumab, siv los kho tus mob follicular lymphoma.

• Brentuximab vedotin, uas muaj cov monoclonal antibody uas khi rau cov protein hu ua CD30 uas muaj nyob ntawm qee cov lymphoma. Nws tseem muaj cov tshuaj anticancer uas tuaj yeem pab tua cov kabmob kheesxaws.

• Yttrium Y 90-ibritumomab tiuxetan, ib qho piv txwv ntawm cov radiolabeled monoclonal antibody.

Proteasome inhibitor kev kho mob thaiv kev txiav txim ntawm cov proteasomes hauv qog hlwb. Proteasomes tshem tawm cov protein tsis tas yuav los ntawm lub cell. Thaum cov proteasomes raug thaiv, cov protein ua haujlwm hauv lub cell thiab tuaj yeem ua rau tus kabmob kheesxaws tuag. Bortezomib yog siv los txo qis ntau npaum li cas immunoglobulin M nyob rau hauv cov ntshav tom qab kev kho mob qog nqaij hlav cancer rau lymphoplasmacytic lymphoma. Nws kuj tseem tau kawm txog los kho cov mob hlwb rov huam.

Kev kho Kinase inhibitor kho cov kev thaiv qee cov protein, uas yuav pab ua kom cov hlwb ua cov hlav ua haujlwm loj thiab tuaj yeem tua lawv. Kev kho mob Kinase muaj xws li:

• Copanlisib, idelalisib, thiab duvelisib, uas thaiv P13K cov protein thiab yuav pab ua kom cov hlwb lymphoma tsis txhob loj hlob tuaj. Lawv siv los kho tus mob follicular uas tsis yog Hodgkin lymphomas uas tau rov mob dua (rov qab los) lossis tsis tau zoo dua tom qab kho nrog tsawg kawg yog ob yam kev kho mob ntxiv.

• Ibrutinib thiab acalabrutinib, hom Bruton tyrosine kinase inhibitor kev kho. Lawv raug siv los kho cov mob lymphoplasmacytic lymphoma thiab mantle cell lymphoma.

Venetoclax kuj tseem siv tau los kho mantle cell lymphoma. Nws txwv qhov kev ua ntawm cov protein hu ua B-cell lymphoma-2 (BCL-2) thiab tuaj yeem pab tua cov qog noj ntshav.

Saib Cov Tshuaj Pom Zoo rau Kev Tsis-Hodgkin Lymphoma yog xav paub ntxiv.

Plasmapheresis

Yog tias cov ntshav ua tuab nrog cov roj ntsha tiv thaiv kab mob ntxiv thiab cuam tshuam kev ncig, plasmapheresis ua tiav kom tshem tawm cov ntshav ntxiv thiab tiv thaiv cov protein tawm ntawm cov ntshav. Nyob rau hauv txoj kev ua no, cov ntshav raug tshem tawm ntawm tus neeg mob thiab xa los ntawm lub tshuab uas cais cov ntshav (cov kua ntawm cov ntshav) los ntawm cov ntshav. Tus neeg mob cov ntshav muaj cov tshuaj tiv thaiv uas tsis tsim nyog thiab tsis rov qab rau tus neeg mob. Cov qe ntshav li qub tau rov qab los rau hauv cov hlab ntshav nrog rau cov ntshav ntshav los yog ntshav hloov. Plasmapheresis tsis khaws cia cov tshuaj tiv thaiv tshiab los ntawm kev sib sau.

Xyuam xim tos

Kev tos kom ceev faj yog saib xyuas tus neeg mob kom zoo tsis tas kho mob kom txog thaum muaj cov tsos mob tshwm sim los yog hloov.

Tshuaj tua kab mob kho

Tshuaj tua kab mob yog kev kho mob uas siv tshuaj los kho kab mob thiab mob qog ntshav los ntawm kab mob thiab lwm yam kab mob me.

Saib Cov Tshuaj Pom Zoo rau Kev Tsis-Hodgkin Lymphoma yog xav paub ntxiv.

Kev phais mob

Kev phais mob siv tau los tshem tawm cov qog ntshav hauv qee cov neeg mob uas tsis mob siab lossis tsis hnyav-tsis Hodgkin lymphoma.

Kev siv phais yog siv nyob ntawm seb qhov twg lymphoma tsim nyob rau hauv lub cev:

• Kev txiav txim siab hauv zos rau qee tus neeg mob muaj hnoos qeev-cuam tshuam lymphoid nqaij (MALT) lymphoma, PTLD, thiab tso quav me me T-cell lymphoma.

• Splenectomy rau cov neeg mob marginal tsam lymphoma ntawm tus po.

Cov neeg mob uas muaj lub plawv, mob ntsws, mob siab, mob raum, lossis mob raum tuaj feem ntau yuav tsum tau noj tshuaj los txhawm rau tiv thaiv lawv lub cev mus tas lub neej. Kev siv tshuaj tiv thaiv ntev tom qab hloov khoom nruab nrog cev tuaj yeem ua rau qee yam mob uas tsis yog Hodgkin lymphoma hu ua post-transplant lymphoproliferative Disorder (PLTD).

Kev phais plab me me feem ntau xav tau los tshawb nrhiav tus kab mob celiac hauv cov neeg laus uas tau tsim hom T-cell lymphoma.

Qia cell hloov

Kev hloov cov qog ua cell yog ib txoj kev muab tshuaj siab ntau thiab / los yog kev tiv thaiv lub cev tag nrho thiab tom qab ntawd hloov cov qe ntshav tsim los ntawm kev kho mob cancer. Cov qia hlwb (cov qe ntshav tsis txaus) raug tshem tawm los ntawm cov ntshav lossis pob txha mob ntawm tus neeg mob (hloov ntshav ntawm tus kheej) lossis tus neeg pub (hloov ntshav tag nrho) thiab raug khov thiab khaws cia. Tom qab kev siv tshuaj thiab / lossis hluav taws xob kho tiav, lub qia hlwb raug yaj thiab muab rov qab rau tus neeg mob los ntawm kev pleev tshuaj. Cov qog ntshav qog ua kom loj hlob mus rau (thiab txum tim) lub cev cov ntshav.

Qia cell hloov. (Kauj Ruam 1): Ntshav tau txais los ntawm cov leeg ntshav hauv caj npab ntawm tus neeg pub ntshav. Tus neeg mob lossis lwm tus tuaj yeem ua tus pub. Cov ntshav ntws dhau los ntawm lub tshuab uas tshem cov qia. Tom qab ntawd cov ntshav xa rov qab rau tus neeg pub ntshav los ntawm txoj hlab ntsha hauv lwm sab caj npab. (Kauj Ruam 2): Tus neeg mob tau txais tshuaj kho mob los tua cov qe tsim cov ntshav. Tus neeg mob yuav tau txais kev kho mob hluav taws xob (tsis qhia). (Kauj Ruam 3): Tus neeg mob tau txais cov qia hlwb los ntawm txoj raj tso rau hauv cov hlab ntshav hauv siab.

Cov hom kev kho mob tshiab tau raug sim hauv qhov kev sim kho mob.

Tshooj lus kawg piav txog kev kho mob uas tau kawm hauv kev sim tshuaj. Nws yuav tsis hais txog txhua txoj kev kho tshiab tau kawm. Cov ntaub ntawv hais txog kev sim kho mob muaj nyob rau ntawm NCI lub vev xaib.

Tshuaj kho tiv thaiv

Kev siv tshuaj tiv thaiv yog kev kho mob cancer uas yog siv cov tshuaj los yog pawg ntawm cov tshuaj los txhawb kev tiv thaiv kab mob kom pom cov qog thiab tua nws.

Cov neeg mob yuav xav txog kev sim kho mob.

Txog qee tus neeg mob, koom nrog kev sim kho mob yuav yog txoj kev xaiv zoo tshaj plaws. Cov chaw kuaj mob yog ib feem ntawm cov txheej txheem tshawb mob qog noj ntshav. Cov chaw kho mob tau sim ua kom pom tias kev kho mob qog noj ntshav tshiab muaj kev nyab xeeb thiab zoo dua lossis zoo dua cov qauv tshuaj.

Ntau yam ntawm cov qauv kev kho mob qog noj ntshav niaj hnub no yog los ntawm cov kev tshawb fawb kab mob thaum ntxov. Cov neeg mob uas koom nrog kev sim kho mob tuaj yeem tau txais cov qauv kev kho mob lossis ua thawj zaug tau txais kev kho mob tshiab.

Cov neeg mob uas koom nrog kev sim kho mob kuj pab txhim kho txoj kev kho mob qog nqaij hlav yav tom ntej. Txawm hais tias kev sim tshuaj sim tsis ua rau muaj kev kho mob tshiab, lawv feem ntau teb cov lus nug tseem ceeb thiab pab txav kev tshawb fawb tom ntej.

Cov neeg mob tuaj yeem nkag mus kuaj mob ua ntej, sijhawm, lossis tom qab pib kho mob qog noj ntshav.

Qee qhov kev sim tshuaj tsuas yog suav nrog cov neeg mob uas tseem tsis tau txais kev kho mob. Lwm txoj kev sim sim cov kev kho mob rau cov neeg mob uas mob qog noj qab tsis tau zoo dua. Kuj tseem muaj cov kev sim tshuaj kuaj mob uas sim txoj kev tshiab los txwv qog noj ntshav kom tsis txhob mob ntxiv (rov qab los) lossis txo kev phiv los ntawm kev kho mob qog noj.

Cov chaw kuaj mob tau tshwm sim nyob rau ntau lub tebchaws. Cov ntaub ntawv hais txog kev sim kho mob uas tau txhawb nqa los ntawm NCI tuaj yeem nrhiav pom ntawm NCI cov chaw kuaj mob tshawb nrhiav lub vev xaib. Cov chaw kuaj mob txhawb nqa los ntawm lwm cov koomhaum tuaj yeem nrhiav pom ntawm ClinicalTrials.gov lub vev xaib.

Tej zaum yuav tau ua raws li kev ntsuam xyuas.

Qee qhov kev ntsuas mob uas tau ntsuas los kuaj mob qog noj ntshav lossis kom pom tias theem mob cancer yuav rov qab ua dua. Qee qhov kev ntsuas yuav rov ua qhov qub txhawm rau kom pom tias qhov kev kho mob ua haujlwm li cas. Cov kev txiav txim siab hais txog seb puas yuav txuas ntxiv, hloov, lossis tsum tsis mus kho yuav ua raws cov txiaj ntsig ntawm cov kev ntsuas no.

Qee qhov kev sim yuav txuas ntxiv ua ib zaug dhau ib zaug tom qab kho tas. Qhov tshwm sim ntawm kev sim no tuaj yeem qhia tau yog tias koj tus mob tau hloov lossis yog tias mob qog rov qab (rov qab los). Qee qhov kev ntsuas no qee zaum hu ua kev kuaj mob rov qab lossis mus kuaj mob.

Kev Kho Mob ntawm Indolent Tsis-Hodgkin Lymphoma

Yog xav paub txog cov kev kho mob uas teev rau hauv qab no, saib hauv Cov Lus Qhia Kev Xaiv Kev Xaiv.

Kev kho mob tsis tseem ceeb ntawm theem I thiab tsis tseem ceeb, tsis nyob sib luag ntu II tus neeg laus tsis mob Hodgkin lymphoma tuaj yeem suav nrog cov hauv qab no:

• Kev siv hluav taws xob.
• Monoclonal antibody therapy (rituximab) thiab / lossis kev siv tshuaj kho.
• Xyuam xim tos.

Yog tias cov qog ntshav loj dhau los nrog kev kho hluav taws xob, txoj kev kho mob rau kev tsis tuaj yeem, tsis ua haujlwm theem II, III, lossis IV tus neeg laus tsis-Hodgkin lymphoma yuav siv.

Kev kho mob ntawm indolent, noncontiguous theem II, III, lossis IV neeg laus-Hodgkin lymphoma tuaj yeem suav nrog cov hauv qab no:

• Kev ceev faj tos rau cov neeg mob uas tsis muaj cov cim lossis cov tsos mob.

• Monoclonal antibody therapy (rituximab) nrog lossis tsis muaj tshuaj tua kab mob.

• Kev saib xyuas kev kho mob nrog rituximab.

• Kev kho mob monoclonal antibody (obinutuzumab).

• PI3K inhibitor kev kho (copanlisib, idelalisib, lossis duvelisib).

• Lenalidomide thiab rituximab.

• Radiolabeled monoclonal tshuaj tiv thaiv kev kho mob.

• Kev sim tshuaj kho cov kws kho mob siab tshaj plaws nrog lossis tsis muaj tag nrho lub cev tsis haum lossis radiolabeled monoclonal antibody therapy, taug kev los ntawm

• autologous lossis allogeneic qia cell hloov ntshav.

• Kev sim tshuaj ntawm cov kws khomob nrog lossis tsis muaj tshuaj tiv thaiv.

• Ib qho kev sim kho mob ntawm cov tshuaj tiv thaiv kab mob monoclonal tshiab.

• Kev sim tshuaj rau hluav taws xob kho uas suav nrog cov qog ntshav nyob ze, rau cov neeg mob tus mob III.

• Kev sim tshuaj ntsuam cov tshuaj tiv thaiv hluav taws xob tsawg, txhawm rau txo cov tsos mob thiab txhim kho lub neej zoo.

Lwm txoj kev kho rau cov tsis muaj Hodgkin lymphoma nyob ntawm seb hom tsis-Hodgkin lymphoma. Kev kho mob yuav suav nrog cov hauv qab no:

• Txog cov kab mob tso ntshav qab zib, kev kho mob yuav yog nyob hauv kev sim kho cov kev siv tshuaj tua kab mob monoclonal tshiab, kev kho cov tshuaj tua kab mob tshiab, lossis cov qia

kev hloov ntawm tes.

• Txog follicular lymphoma uas rov mob ntxiv (rov qab los) lossis tsis tau zoo dua tom qab kho, txoj kev kho yuav suav nrog PI3K inhibitor

(copanlisib, idelalisib, lossis duvelisib).

• Txog kev mob qog ua ntshav qab zib, Bruton tyrosine kinase inhibitor kho thiab / lossis plasmapheresis lossis kev kho mob proteasome inhibitor (yog tias xav tau

txhawm rau ua cov ntshav thinner) siv. Kuj tseem yuav muab lwm txoj kev kho mob uas zoo li siv rau cov ntshav qab zib qe ntshav qab zib.

• Txog kev mob plab hnyuv-cuam tshuam lymphoid nqaij (MALT) lymphoma, tshuaj tua kab mob los kho tus mob Helicobacter pylori yog muab ua ntej.

Rau cov qog uas tsis teb tshuaj tua kab mob, kev kho mob yog kev kho hluav taws xob, phais mob, lossis rituximab nrog lossis tsis muaj tshuaj tua kab mob.

• Txog kev ua kom mob MALT lymphoma ntawm lub qhov muag thiab Mediterranean lymphoma mob plab, kho cov tshuaj tiv thaiv kab mob yog siv los kho kab mob.

• Rau splenic marginal tsam lymphoma, rituximab nrog lossis tsis muaj tshuaj tua kab mob thiab B-cell receptor txoj kev kho yog siv los ua kev kho mob thaum pib. Yog tias cov qog tsis hnov ​​qab txog kev kho mob, nws yuav ua kom tau qhov hnoos qeev.

Kho Tus Mob Loj Tsis-Hodgkin Lymphoma

Yog xav paub txog cov kev kho mob uas teev rau hauv qab no, saib hauv Cov Lus Qhia Kev Xaiv Kev Xaiv.

Kev kho mob ntawm kev ua ntu zus I thiab kev nruj, qhov tsis sib haum ntawm qib II neeg laus tsis-Hodgkin lymphoma tuaj yeem suav nrog cov hauv qab no:

• Monoclonal antibody therapy (rituximab) thiab kev sib txuas nrog tshuaj kho mob. Qee zaum siv tshuaj tua hluav taws xob tom qab.

• Kev sim tshuaj rau kab mob kev noj tshuaj tshiab ntawm cov tshuaj tua kab mob monoclonal thiab kev siv tshuaj kho mob sib ntxiv.

Kev kho mob ntawm kev txhoj puab heev, tsis mob siab rau theem II, III, lossis IV neeg laus tsis mob Hodgkin lymphoma tuaj yeem suav nrog cov hauv qab no:

• Monoclonal antibody therapy (rituximab) nrog kev sib ntxiv ntawm kev kho mob.

• Kev sib xyaw nrog kev kho tshuaj.

• Kev sim tshuaj ntawm monoclonal tshuaj tiv thaiv kev kho mob nrog kev siv tshuaj sib xyaw ua ke nrog kev kho mob hluav taws xob.

Lwm txoj kev kho yog nyob ntawm seb hom tawv nqaij tsis hnyav Hodgkin lymphoma. Kev kho mob yuav suav nrog cov hauv qab no:

• Txog extranodal NK- / T-cell lymphoma, kho hluav taws xob uas yuav tsum tau muab ua ntej, thaum, lossis tom qab siv tshuaj tua kab mob thiab CNS prophylaxis.

• Rau mantle cell lymphoma, monoclonal antibody therapy nrog cov tshuaj sib xyaw ua ke, tom qab ntawd hloov qia cell. Kev noj tshuaj Monoclonal antibody therapy tom qab kho kev kho mob (kev kho mob uas tau muab tom qab pib kho los pab ua kom mob qog rov qab los).

• Rau posttransplantation lymphoproliferative tsis meej, kev kho mob nrog koob tshuaj tiv thaiv kab mob tej zaum yuav nres. Yog tias qhov no tsis ua haujlwm lossis tsis tuaj yeem ua tiav, monoclonal antibody therapy ib leeg lossis nrog kev kho tshuaj kho mob yuav tau muab. Rau kev mob qog noj uas tsis kis, yuav siv phais mob los tshem tawm cancer lossis hluav taws xob kho.

• Rau plasmablastic lymphoma, kev kho mob yog zoo li cov uas siv rau cov mob lymphoblastic lymphoma lossis Burkitt lymphoma.

Yog xav paub txog kev kho mob lymphoblastic lymphoma, saib Kev Xaiv Kho rau Lymphoblastic Lymphoma thiab kom paub txog kev kho Burkitt lymphoma, saib Cov Cai Kho rau Burkitt Lymphoma.

Kev Kho Mob Lymphoblastic Lymphoma

Yog xav paub txog cov kev kho mob uas teev rau hauv qab no, saib hauv Cov Lus Qhia Kev Xaiv Kev Xaiv.

Kev kho mob qog nqaij hlav cancer rau cov neeg laus yuav tsum muaj cov hauv qab no:

• Kev siv tshuaj sib xyaw ua ke thiab CNS prophylaxis. Qee zaum kev muab tshuaj tua hluav taws xob txhawm rau kom hlav lub qog loj.

• Kev kho hom phiaj nrog lub monoclonal antibody ib leeg (rituximab) los yog ua ke nrog kev kho mob kinase inhibitor (ibrutinib).

• Kev soj ntsuam kuaj kab mob ntawm tes hloov qov tom qab pib siv tshuaj.

Kev Kho Mob ntawm Burkitt Lymphoma

Yog xav paub txog cov kev kho mob uas teev rau hauv qab no, saib hauv Cov Lus Qhia Kev Xaiv Kev Xaiv.

Kev kho mob ntawm cov neeg laus Burkitt lymphoma tuaj yeem suav nrog cov hauv qab no:

• Kev sib xyaw nrog kev kho mob nrog lossis tsis muaj tshuaj monoclonal antibody therapy.

• CNS prophylaxis.

Kev kho mob ntawm Kev Mob Tshaj Plaws Tsis-Hodgkin Lymphoma

Yog xav paub txog cov kev kho mob uas teev rau hauv qab no, saib hauv Cov Lus Qhia Kev Xaiv Kev Xaiv.

Kev kho ntawm tsis tuaj yeem, cov laus ib txwm tsis-Hodgkin lymphoma tuaj yeem suav nrog cov hauv qab no:

• Kev siv tshuaj kho mob nrog ib lossis ntau yam tshuaj.

• Kev kho mob monoclonal antibody (rituximab lossis obinutuzumab).

• Lenalidomide.

• Radiolabeled monoclonal tshuaj tiv thaiv kev kho mob.

• Kev siv hluav taws xob zoo li kev kho mob palliative kom txo cov tsos mob thiab txhim kho lub neej zoo.

• Kev soj ntsuam kab mob hauv lub cev hloov ntshav ntawm cev muaj zog los yog qog nqaij hlav sib hloov tuaj.

Kev kho mob ntawm cov neeg laus tsis xws li Hodgkin lymphoma tuaj yeem suav nrog cov hauv qab no:

• Kws khomob muaj lossis hloov tsis hloov qia ntawm tes.

• Monoclonal antibody therapy nrog lossis tsis muaj kev sib ntxiv los ntawm kev kho mob tom qab los ntawm kev hloov kho lub cev ntawm tes ua pob zeb.

• Kev siv hluav taws xob zoo li kev kho mob palliative kom txo cov tsos mob thiab txhim kho lub neej zoo.

• Radiolabeled monoclonal tshuaj tiv thaiv kev kho mob.

• Kev kho T-cell kho mob.

• Rau mantle cell lymphoma, kev kho mob yuav suav nrog cov hauv qab no:

• Bruton tyrosine kinase inhibitor kho.

• Lenalidomide.

• Kev sim kho mob ntawm lenalidomide nrog monoclonal antibody therapy.

• Ib qho kev sim kho mob sib piv lenalidomide rau lwm txoj kev kho.

• Kev soj ntsuam kab mob ntawm cov tshuaj proteasome inhibitor kho (bortezomib).

• Kev soj ntsuam kuaj kab mob hauv lub cev los sis cov qog neeg tawm ntawm txoj kev hloov ntshav ntawm tes.

Kev kho mob ntawm cov mob lymphoma tsis muaj zog uas tau rov qab los ntawm kev mob qog ua kua qog ua raws li hom tsis-Hodgkin lymphoma thiab tej zaum yuav muaj kev kho hluav taws xob raws li kev kho mob palliative los daws cov tsos mob thiab txhim kho lub neej zoo. Kev kho cov qog ua tshuaj lymphoma tawm rov qab los uas tsis muaj cov mob lymphoma kuj suav nrog kev kho mob.

Kev Kho Mob Ntawm Tsis-Hodgkin Lymphoma Thaum Cev Xeeb Tub

Hauv Tshooj Lus no

• Indolent Tsis-Hodgkin Lymphoma Thaum Cev Xeeb Tub

• Kev Loj Dhau Tsis Hodgkin Lymphoma Thaum Cev Xeeb Tub

Yog xav paub txog cov kev kho mob uas teev rau hauv qab no, saib hauv Cov Lus Qhia Kev Xaiv Kev Xaiv.

Indolent Tsis-Hodgkin Lymphoma Thaum Cev Xeeb Tub

Cov poj niam uas muaj qhov tsis nco qab (maj mam loj hlob) uas tsis yog Hodgkin lymphoma thaum cev xeeb tub yuav raug saib xyuas nrog tos kom txog thaum tom qab lawv yug tas. (Saib Cov Lus Qhia Kev Kho Mob rau Qhov Tsis Yog-Hodgkin Lymphoma rau cov lus qhia ntxiv.)

Kev Loj Dhau Tsis Hodgkin Lymphoma Thaum Cev Xeeb Tub

Kev kho mob ntawm kev txhoj puab heev tsis-Hodgkin lymphoma thaum cev xeeb tub yuav suav nrog cov hauv qab no:

• Cov kev kho mob muab tam sim ntawd raws li hom tsis-Hodgkin lymphoma kom niam txoj sia muaj sia nyob ntev. Txoj kev kho yuav suav nrog kev siv tshuaj sib tov thiab rituximab.

• Kev yug menyuam thaum ntxov ua raws kev kho mob raws li hom tsis mob Hodgkin lymphoma.

• Yog tias nyob rau thawj peb lub hlis thaum cev xeeb tub, cov kws kho mob paub txog qhov cev xeeb tub kom thiaj li pib kho. Kev kho yog nyob ntawm hom tsis-Hodgkin lymphoma.

Xav Kom Paub Ntxiv Txog Cov Neeg Laus Tsis-Hodgkin Lymphoma

Yog xav paub ntxiv los ntawm National Cancer Institute txog cov neeg laus tsis mob Hodgkin lymphoma, saib cov hauv qab no:

• Tsis-Hodgkin Lymphoma Lub Tsev Nplooj Ntawv

• Tshuaj Pom Zoo rau Cov Tshuaj Uas Tsis Yog Hodgkin Lymphoma

• Hom Kab Mob Kuaj Mob Cancer

• Tshuaj Kho Mob Los Kho Mob Cancer

Txog kev qhia txog kabmob kheesxaws thoob plaws thiab lwm yam kev pabcuam los ntawm National Cancer Institute, saib cov hauv qab no:

• Txog Mob Cancer

• Qib

• Kev Siv Tshuaj Kho Mob thiab Koj: Txhawb Rau Cov Neeg Muaj Mob Cancer

• Qhov Kev Mob Hlaws Hluav Taws Xob thiab Koj: Txhawb Rau Cov Neeg Muaj Mob Cancer

• Kev Muaj Mob Cancer

• Cov Lus Nug Yuav Nug Koj Tus Kws Kho Mob txog Kab Mob Cancer

• Rau Cov Muaj Txoj Sia Nyob thiab Cov Saib Xyuas