Hom / mob leukemia / neeg mob / menyuam-tag nrho-kev kho mob-pdq

Ac Tus Menyuam Muaj Mob Loj Lymphoblastic Kev Mob Ntshav Qab Zib ( ®) atPab Niam Ntawv

Cov Lus Qhia Txog Hais Txog Kev Loj Hlob Me Mob Ntshav Qab Zib Lymphoblastic

QHOV TSEEM CEEB

• Cov menyuam yaus lub cev qog ua ntshav (Lymphoblastic leukemia) thaum menyuam mob (TXHUA) yog hom mob cancer uas cov hlwb pob txha ua rau cov lymphocytes tsis paub qab hau heev (ib hom qe ntshav dawb).

• Mob ntshav qog yuav cuam tshuam rau cov qe ntshav liab, qe ntshav dawb, thiab qe ua ntshav khov.

• Cov kev kho yav dhau los rau mob qog noj ntshav thiab qee yam mob caj ces cuam tshuam txog kev pheej hmoo ntawm kev muaj menyuam yaus TXHUA.

• Cov cim ntawm tus menyuam yaus TXHUA ua suav nrog ua npaws thiab ua pob.

• Kev ntsuam xyuas uas tshuaj xyuas cov ntshav thiab pob txha pob txha yog siv los kuaj (pom) thiab kuaj xyuas menyuam yaus TAG NRHO.

• Qee yam cuam tshuam txog kev raug (mob rov qab) thiab txoj kev kho.

Cov menyuam yaus lub cev qog ua ntshav (Lymphoblastic leukemia) thaum menyuam mob (TXHUA) yog hom mob cancer uas cov hlwb pob txha ua rau cov lymphocytes tsis paub qab hau heev (ib hom qe ntshav dawb).

Kev mob qog ua ntshav rau menyuam yaus (tseem hu ua TXHUA los yog mob cov qe ntshav dawb) yog mob qog ntshav ntshav thiab mob hlwb pob txha. Hom kabmob no feem ntau mob heev dua yog tias tsis kho.

Anatomy ntawm pob txha. Lub pob txha ua los ntawm cov pob txha sib dhos, pob txha hno, thiab pob txha pob txha. Cov pob txha sib xyaw ua rau cov txheej txheem sab nrauv ntawm pob txha. Daim tawv pob txha muaj nyob hauv qhov kawg ntawm cov pob txha thiab muaj cov hlwb liab. Hlwb Pob Txha yog nyob hauv plawv feem ntau ntawm cov pob txha thiab muaj ntau cov hlab ntshav. Muaj ob hom pob txha pob txha: liab thiab daj. Cov hlwb liab muaj cov qe ntshav liab uas tuaj yeem dhau los ua cov ntshav liab, cov qe ntshav dawb, lossis qe ua ntshav khov. Cov roj ntsha daj ua cov rog feem ntau.

TXHUA yog feem ntau hom mob cancer rau menyuam yaus.

Mob ntshav qog yuav cuam tshuam rau cov qe ntshav liab, qe ntshav dawb, thiab qe ua ntshav khov.

Hauv cov menyuam yaus noj qab haus huv, cov hlwb pob txha ua rau cov qe ntshav (lub hlwb tsis paub qab hau) uas ua cov qe ntshav thaum lub sijhawm dhau los. Cov qe ntshav ntshav yuav dhau los ua myeloid qia cell los yog lymphoid qia cell.

Myeloid qia cell dhau los ua ib qho ntawm peb hom qe ntshav loj:

• Cov ntshav liab uas xa cov pa oxygen thiab lwm yam tshuaj rau txhua qhov nqaij ntawm lub cev.

• Platelets uas ua rau cov ntshav txhaws txhaws kom los ntshav.

• Cov qe ntshav dawb uas tawm tsam kev kis mob thiab kab mob.

Lymphoid qia cell dhau los ua lymphoblast cell thiab tom qab ntawd ib qho ntawm peb hom lymphocytes (cov qe ntshav dawb):

• B lymphocytes uas ua kom muaj cov tshuaj tiv thaiv kab mob los pab tua kab mob.

• T lymphocytes uas pab B lymphocytes ua rau cov tshuaj tiv thaiv uas pab tua kab mob sib kis.

• Tus kab mob tua neeg uas tua cov qog noj ntshav thiab kab mob.

Kev loj hlob ntawm cov ntshav. Cov qe ntshav muaj hla ntau kauj ruam dhau los ua lub qe ntshav liab, ntshav tawm, lossis qe ntshav dawb.

Hauv cov menyuam yaus nrog TXHUA, cov qia hlwb ntau dhau los ua lymphoblasts, B lymphocytes, lossis T lymphocytes. Lub hlwb tsis ua haujlwm zoo li cov lymphocytes li qub thiab tsis tuaj yeem tiv thaiv kev kis mob tau zoo heev. Cov qe ntshav no yog cov mob hlwb (mob leukemia). Tsis tas li, raws li cov lej ntawm cov ntshav muaj ntshav ntau yuav ua rau cov ntshav thiab cov pob txha pob txha, nws muaj tsawg chav rau cov qe ntshav dawb zoo, qe ntshav liab, thiab qe ntshav. Qhov no tuaj yeem ua rau kis kab mob, ua haujlwm tsis txaus, thiab los ntshav yoojyim.

Cov ntsiab lus no yog hais txog cov mob ntshav thiav thiav hauv cov menyuam, cov hluas, thiab cov neeg hluas. Saib cov lus piav qhia txog hauv qab no rau cov ntaub ntawv hais txog lwm hom mob qog ntshav:

• Menyuam yaus Mob Hlwb Ntsia Tus Mob Hlav Ntxhuav / Lwm Tus Mob Myeloid Malignancies

• Kho Tus Mob Loj Tus Mob Lymphoblastic Kev Mob Ntshav Siab

• Kho Mob Lymphocytic Ntau Tus Mob Ntshav Qab Zib

• Yuav Kho Cov Neeg Mob Caws Khov Kho Tus Mob Hlwb Ntxhuav

• Mob Hlwb Ntuav Ua Kom Mob Hlwb Tes Taw Hlwb Mob

• Plaub Cawv Kho Mob Ntshav Qab Zib

Cov kev kho yav dhau los rau mob qog noj ntshav thiab qee yam mob caj ces cuam tshuam txog kev pheej hmoo ntawm kev muaj menyuam yaus TXHUA.

Txhua yam uas ua rau koj muaj feem yuav kis tus mob yog hu ua kev pheej hmoo. Muaj qhov muaj feem yuav tsis txhais tau tias koj yuav muaj mob qog noj ntshav; tsis muaj yam txaus ntshai tsis txhais tau tias koj yuav tsis muaj mob qog noj ntshav. Tham nrog koj tus menyuam tus kws kho mob yog tias koj xav tias koj tus menyuam raug pheej hmoo.

Cov kev pheej hmoo txaus ntshai rau TXHUA suav nrog cov hauv qab no:

• Raug rau xoo hluav taws xob ua ntej yug.

• Raug rau hluav taws xob.

• Yav dhau los kho nrog kev kho tshuaj.

• Muaj qee yam mob raws caj ces, xws li:

• Mob ntsws qis.

• Neurofibromatosis hom 1.

• Mob syndrome.

• Fanconi anemia.

• Ataxia-telangiectasia.

• Li-Fraumeni syndrome.

• Kev cai tsis sib xws los kho qhov tsis muaj peev xwm (hloov pauv tau hauv qee cov noob uas txwv DNA los kho nws tus kheej, uas ua rau kev loj hlob ntawm cov qog nqaij hlav thaum tseem hluas).

• Muaj qee qhov kev hloov pauv hauv cov chromosomes lossis noob.

Cov cim ntawm tus menyuam yaus TXHUA ua suav nrog ua npaws thiab ua pob.

Cov no thiab lwm yam cim thiab tsos mob tuaj yeem tshwm sim tau los ntawm menyuam yaus TXHUA los yog lwm yam mob. Nrog koj tus menyuam tus kws kho mob tham yog tias koj tus menyuam muaj tej yam hauv qab no:

• Ua npaws.

• Ua kom doog ntshav yooj yim lossis los ntshav.

• Petechiae (tiaj, taw, xim tsaus nti hauv qab daim tawv nqaij tshwm sim los ntawm los ntshav).

• Mob pob txha lossis mob pob txha.

• Kev mob nyob hauv lub caj dab, tsis txaus ntseeg, plab, lossis puab tais.

• Mob los yog hnov ​​tag nrho hauv qab cov tav.

• Tsis muaj zog, nkees, lossis saib tsis taus.

• Tsis qab los noj mov.

Kev ntsuam xyuas uas tshuaj xyuas cov ntshav thiab pob txha pob txha yog siv los kuaj (pom) thiab kuaj xyuas menyuam yaus TAG NRHO.

Cov kev tshuaj ntsuam thiab cov txheej txheem hauv qab no yuav raug siv coj los soj ntsuam menyuam yaus TAG NRHO thiab nrhiav seb puas muaj cov qe ntshav muaj ntshav tau kis mus rau lwm qhov ntawm lub cev xws li lub hlwb lossis cov noob qes:

Kev kuaj lub cev thiab keeb kwm: Kev tshuaj xyuas lub cev los kuaj cov cim ntawm kev noj qab haus huv, suav nrog kuaj lub cim ntawm tus kab mob, xws li cov qog lossis lwm yam uas zoo li txawv txawv. Cov keeb kwm ntawm tus neeg mob txoj kev noj qab haus huv thiab cov kab mob yav dhau los thiab kev kho mob tseem yuav raug coj los siv.

Ua kom tiav cov ntshav suav (CBC) nrog kev sib txawv: Ib txoj kev ua uas coj los ntsuas thiab kuaj xyuas cov hauv qab no:

• Tus lej ntawm cov ntshav liab thiab cov qe ntshav.

• Tus lej thiab hom ntshav dawb.

• Cov ntshav hemoglobin (cov protein uas nqa oxygen) hauv cov ntshav liab.

• Feem ntawm cov qauv ua los ntawm cov ntshav liab.

Ua kom tiav cov ntshav suav (CBC). Ntshav yog sau los ntawm kev ntxig ib rab koob rau hauv cov leeg thiab pub cov ntshav tuaj rau hauv lub raj. Cov ntshav ntsuas raug xa mus rau chav kuaj thiab ntshav liab, ntshav dawb, thiab cov ntshav khov yog suav. Lub CBC yog siv los ntsuas rau, ntsuas mob, thiab saib xyuas ntau yam mob.

• Kev tshawb fawb hauv ntshav cov ntshav: Tus txheej txheem tso ntshav kuaj ntsuas los ntsuas cov khoom tshuaj uas tso rau hauv ntshav los ntawm cov plab hnyuv siab raum thiab cov nqaij hauv lub cev. Ib qho txawv (ntau dua lossis qis dua qub) ntawm cov tshuaj yuav ua rau lub cim ntawm tus kabmob.

• Mob pob txha rau txoj kev cia siab thiab kuaj me me: Tshem tawm cov pob txha pob txha thiab ib qho me me ntawm pob txha los ntawm ntxig rab koob hollow rau hauv lub duav lossis ob lub mis. Tus kws kho mob hais txog pob txha caj qaum thiab pob txha nyob hauv lub tshuab tsom seb puas pom cov cim mob qog nqaij hlav.

Nqaij pob txha txhaws thiab nqus xyoob. Tom qab qhov chaw me me ntawm daim tawv nqaij loog, xoos pob txha pob txha tau tso rau hauv tus menyuam pob txha pob txha. Cov hnoos qeev ntshav, pob txha, thiab pob txha pob txha tau raug tshem tawm mus kuaj hauv lub tshuab tsom.

Cov kev ntsuam xyuas hauv qab no yog ua rau cov ntshav lossis cov leeg pob txha uas raug tshem tawm:

• Kev tshuaj ntsuam Cytogenetic: Kev sim tshuaj uas cov chromosomes ntawm cov hlwb hauv ib qho qauv ntawm cov ntshav lossis pob txha txhawm rau suav thiab txheeb xyuas rau txhua qhov hloov pauv, xws li tawg, ploj, rov kho dua, lossis ntxiv rau cov xoos xoos. Kev hloov qee yam chromosomes yuav yog mob qog nqaij hlav. Piv txwv, hauv Philadelphia chromosome – positive TXHUA, ib feem ntawm ib qho chromosome hloov chaw nrog ib feem ntawm lwm tus chromosome. Qhov no hu ua “Philadelphia chromosome.” Cytogenetic tsom xam yog siv los pab ntsuas mob qog noj ntshav, npaj kev kho mob, lossis pom tias kev kho mob ua haujlwm tau zoo npaum li cas.

Philadelphia chromosome. Ib daig ntawm cov chromosome 9 thiab ib daim ntawm cov chromosome 22 tawg tawm thiab cov chaw lag luam. BCR-ABL gene yog tsim nyob rau ntawm chromosome 22 qhov twg daim ntawm chromosome 9 txuas. Lub hloov pauv chromosome 22 yog hu ua Philadelphia chromosome.

• Immunophenotyping: Kev sim tshuaj uas siv tshuaj tiv thaiv kab mob ntawm cov qog nqaij hlav cancer ua raws li hom antigens lossis cim rau ntawm cov kem hlwb. Kev kuaj ntshav no yog siv los pab txheeb xyuas qee hom ntshav qab zib. Piv txwv, cov qog nqaij hlav cancer raug kuaj xyuas seb lawv puas yog B lymphocytes lossis T lymphocytes.

• Lumbar puncture: Tus txheej txheem siv los sau cov qauv ntawm cerebrospinal kua (CSF) los ntawm pob txha caj qaum. Qhov no yog ua los ntawm kev tso ib rab koob ntawm ob pob txha hauv tus nqaj qaum thiab nkag rau hauv CSF puag ncig tus txha nraub qaum thiab hle qhov hnoos qeev. Qhov piv txwv ntawm CSF raug kuaj hauv lub tshuab tsom rau cov cim qhia tias cov qe ntshav mob tau kis mus rau lub hlwb thiab tus txha caj qaum. Qhov txheej txheem no tseem hu ua LP lossis txha caj qaum.

Lumbar puncture. Tus neeg mob pw hauv ib qho chaw curled ntawm lub rooj. Tom qab thaj chaw me me ntawm sab nraub qaum yog numbed, koob koob txha nqaj (ntev dua, nyias koob) tau ntxig rau hauv qhov qis ntawm qhov txha caj qaum kom tshem tawm cov cerebrospinal kua (CSF, qhia hauv xiav). Cov kua dej yuav xa mus rau qhov chaw kuaj sim.

Qhov txheej txheem no yog ua tom qab muaj kab mob leukemia tau txheeb xyuas seb puas muaj cov qe ntshav muaj ntshav tau kis mus rau lub hlwb thiab tus txha caj qaum. Intrathecal kev siv tshuaj kho mob tau muab tom qab hno cov kua tshuaj tawm rau kev kho mob rau cov kab mob hlwb uas yuav kis mus rau lub hlwb thiab tus txha caj qaum.

• Xoo Xaim: Xoos hluav taws xob ntawm cov plab hnyuv siab raum thiab pob txha hauv hauv siab. Qhov xoo hluav taws xob yog ib hom kev tawm dag zog ntawm lub zog uas tuaj yeem nkag mus hauv lub cev thiab mus rau zaj duab xis, ua duab ntawm thaj chaw hauv lub cev. Xoo fais fab xoo lub hauv siab tau ua kom pom tias cov qe ntshav muaj ntshav tau tsim ib qho nyhav nyob hauv nruab nrab ntawm lub hauv siab.

Qee yam cuam tshuam txog kev raug (mob rov qab) thiab txoj kev kho.

Qhov raug (sij hawm rov qab los) yog nyob ntawm:

• Yuav sai npaum li cas thiab cov qog ntshav qis qog ua rau poob qis tom qab thawj lub hlis ntawm kev kho mob.

• Lub hnub nyoog thaum lub sijhawm kuaj mob, poj niam txiv neej, haiv neeg thiab hom neeg twg.

• Tus lej ntawm cov qe ntshav dawb nyob rau hauv cov ntshav thaum lub sijhawm kuaj mob.

• Txawm hais tias lub hlwb mob leukemia tau pib los ntawm B lymphocytes lossis T lymphocytes.

• Txawm hais tias muaj qee yam kev hloov pauv hauv cov chromosomes lossis cov noob ntawm cov lymphocytes uas muaj mob qog noj ntshav.

• Seb tus menyuam puas muaj mob syndrome.

• Seb puas muaj cov qe ntshav muaj nyob rau ntawm lub kua dej cerebrospinal.

• Tus me nyuam qhov hnyav thaum lub sij hawm kuaj mob thiab thaum kho.

Cov kev kho mob xaiv nyob ntawm:

• Txawm hais tias lub hlwb mob leukemia tau pib los ntawm B lymphocytes lossis T lymphocytes.

• Seb tus menyuam puas muaj qhov phom sij-phom sij, pheej hmoo, lossis qhov phom sij – txhua tus.

• Lub hnub nyoog ntawm tus menyuam thaum lub sijhawm kuaj mob.

• Txawm hais tias muaj qee yam kev hloov pauv hauv cov chromosomes ntawm lymphocytes, xws li Philadelphia chromosome.

• Seb tus menyuam tau txais kev kho mob nrog cov tshuaj steroids ua ntej pib kev kho induction.

• Yuav kho sai npaum li cas thiab nws cov qog ntshav qog ua kom ntshav tsawg tsawg li thaum kho.

Txog kev mob qog uas rov mob ntxiv (rov qab los) tom qab kev kho mob, kev kwv yees thiab kev kho mob nyob ntawm seb:

• Ntev npaum li cas nws yog nyob nruab nrab ntawm lub sijhawm kuaj thiab thaum rov qab mob leukemia.

• Txawm hais tias mob leukemia rov qab los rau hauv cov leeg pob txha los yog lwm qhov hauv lub cev.

Cov Pab Pawg Muaj Feem Yuav Raug Me Nyuam Thaum Mob Hlwb Mob Hlwb Mob Qog Dawb Ntshav

QHOV TSEEM CEEB

• Hauv cov menyuam yaus TAG NRHO, cov feem phom sij raug siv los npaj kho mob.

• Rov huam mob thaum yau TXHUA tus mob cancer yog rov qab los tom qab nws kho zoo.

Hauv cov menyuam yaus TAG NRHO, cov feem phom sij raug siv los npaj kho mob.

Muaj peb qho kev pheej hmoo nyob hauv menyuam yaus TAG NRHO. Lawv tau piav raws li:

• Txoj kev pheej hmoo (qis): suav nrog cov menyuam hnub nyoog 1 txog rau 10 xyoo uas muaj cov ntshav dawb hauv tsawg tshaj li 50,000 / µL thaum lub sijhawm kuaj mob.

• Kev pheej hmoo siab: Muaj suav nrog cov menyuam yaus 10 xyoo thiab laus dua thiab / lossis cov menyuam yaus uas muaj cov qe ntshav dawb ntawm 50,000 / µL lossis ntau dua thaum lub sijhawm kuaj mob.

• Kev pheej hmoo siab heev: suav nrog cov menyuam yaus hnub nyoog qis dua 1, cov menyuam yaus uas muaj kev hloov pauv ntawm cov caj ces, cov menyuam yaus uas muaj qhov kev teb qeeb rau kev kho thaum xub thawj, thiab cov menyuam yaus uas muaj cov tsos mob leukemia tom qab thawj 4 lub lim tiam ntawm kev kho mob.

Lwm yam uas cuam tshuam rau cov pab pawg muaj xws li cov hauv qab no:

• Txawm hais tias lub hlwb mob leukemia tau pib los ntawm B lymphocytes lossis T lymphocytes.

• Txawm hais tias muaj qee yam hloov pauv hauv cov chromosomes lossis cov noob ntawm cov lymphocytes.

• Yuav sai npaum li cas thiab nws cov ntshav qog ntshav qis li cas poob rau tom qab kev kho mob thawj zaug.

• Seb puas muaj cov qe ntshav muaj nyob rau ntawm cov ntshav cerebrospinal thaum lub sijhawm kuaj mob.

Nws yog ib qho tseem ceeb kom paub cov pab pawg muaj feem yuav ua phiaj xwm kho. Cov menyuam yaus uas muaj feem ntau lossis feem ntau – muaj feem TXHUA feem ntau yuav tau txais cov tshuaj anticancer ntau dua thiab / lossis cov tshuaj tiv thaiv kab mob ntau dua li cov menyuam yaus uas muaj feem TXHUA TXHUA.

Rov huam mob thaum yau TXHUA tus mob cancer yog rov qab los tom qab nws kho zoo.

Mob leukemia tuaj yeem rov qab tuaj rau hauv cov ntshav thiab pob txha pob txha, mob hlwb, txha caj qaum, noob qes, lossis lwm qhov chaw ntawm lub cev.

Refractory thaum yau TXHUA mob cancer uas tsis teb rau kev kho mob.

Txoj Kev Kho Mob Cov Tswv Yim

QHOV TSEEM CEEB

• Muaj ntau ntau hom kev kho mob rau menyuam yaus cov mob qog ua kua ntshav dhia (TXHUA).

• Cov menyuam yaus nrog TXHUA tus menyuam yuav tsum tau npaj lawv li kev kho mob los ntawm pab kws khomob uas yog tus kws paub txog kev kho mob qog ntshav rau menyuam yaus.

• Kev kho mob rau cov menyuam yaus cov mob qog ua kua ntshav thiav ntshav yuav ua rau muaj kev phiv.

• Kev kho mob ntawm menyuam yaus TXHUA feem ntau muaj peb theem.

• Plaub hom kev kho mob raug siv:

• Kws khomob

• Kev siv hluav taws xob

• Siv tshuaj tua kabmob nrog qog cell hloov ntshav

• Cov hom phiaj kho

• Txoj kev kho yog muab los tua cov qog ntshav uas tau kis lossis yuav kis mus rau lub hlwb, tus txha nqaj qaum, lossis cov noob qes.

• Cov hom kev kho mob tshiab tau raug sim hauv qhov kev sim kho mob.

• Chimeric antigen receptor (CAR) Kev Kho Mob T-cell

• Cov neeg mob yuav xav txog kev sim kho mob.

• Cov neeg mob tuaj yeem nkag mus kuaj mob ua ntej, sijhawm, lossis tom qab pib kho mob qog noj ntshav.

• Tej zaum yuav tau ua raws li kev ntsuam xyuas.

Muaj ntau ntau hom kev kho mob rau menyuam yaus cov mob qog ua kua ntshav dhia (TXHUA).

Muaj ntau hom kev kho mob rau cov menyuam yaus mob qog ntshav qog ntshav (TUB) Qee qhov kev kho mob yog tus qauv (cov kev kho mob tam sim no), thiab qee qhov raug sim hauv kev kuaj mob. Ib txoj kev kho mob hauv tsev kho mob yog txoj kev tshawb nrhiav uas pab txhawm rau txhim kho kev kho mob tam sim no lossis tau txais cov ntaub ntawv ntawm kev kho mob tshiab rau cov neeg mob cancer. Thaum kuaj pom tias cov kev kho tshiab zoo dua li kev kho mob, cov kev kho mob tshiab tuaj yeem dhau los ua cov qauv kev kho mob.

Vim tias mob qog noj ntshav rau menyuam yaus yog muaj tsawg, kev koom nrog kev sim tshuaj yuav tsum tau coj los xav. Qee qhov kev sim tshuaj sim tsuas yog qhib rau cov neeg mob uas tsis tau pib kho.

Cov menyuam yaus nrog TXHUA tus menyuam yuav tsum tau npaj lawv li kev kho mob los ntawm pab kws khomob uas yog tus kws paub txog kev kho mob qog ntshav rau menyuam yaus. Kev kho yuav raug saib xyuas los ntawm tus kws kho menyuam yaus, kws kho mob tshwj xeeb hauv kev kho menyuam yaus mob qog noj ntshav. Tus kws kho menyuam yaus ua haujlwm nrog lwm tus kws saib xyuas kev noj qab haus huv menyuam yaus uas yog tus kws tshaj lij hauv kev kho cov menyuam yaus mob qog ntshav thiab leej twg yog tus tshwj xeeb hauv qee yam tshuaj. Cov no yuav suav nrog cov kws tshwj xeeb hauv qab no:

• Kws kho mob hlwb.

• Hematologist.

• Kws tshuaj oncologist.

• Kws phais neeg mob hlwb.

• Kws phais hluav taws xob oncologist.

• Neurologist.

• Neeg muaj txuj ci.

• Kws ntsuas hluav taws xob.

• Kws saib xyuas neeg mob tshwj xeeb.

• Neeg ua hauj lwm pab neeg.

• Cov kws tshaj lij fab kev peem tsheej.

• Kws tshuaj sab laj.

• Tus me nyuam lub neej tshwj xeeb.

Kev kho mob rau cov menyuam yaus cov mob qog ua kua ntshav thiav ntshav yuav ua rau muaj kev phiv.

Yog xav paub txog cov kev mob tshwm sim uas pib thaum kho mob cancer, mus saib peb Nplooj Ntawv Sab Npab.

Kev tshuaj xyuas tas li niaj zaus yog ib qho tseem ceeb heev. Cov kev mob tshwm sim los ntawm kev kho mob cancer uas pib tom qab kho thiab txuas ntxiv rau lub hlis lossis xyoo yog hu ua kev mob lig.

Kev lig dhau los ntawm kev kho mob cancer tej zaum yuav muaj cov hauv qab no:

• Cov teeb meem hauv lub cev, suav nrog cov teeb meem hauv lub plawv, cov hlab ntsha, nplooj siab, lossis pob txha, thiab kev muaj lub cev tsis taus. Thaum dexrazoxane tau muab nrog cov kev siv tshuaj kho mob hu ua anthracyclines, qhov pheej hmoo ntawm cov teebmeem mob plawv lig tsawg dua.

• Hloov pauv hauv txoj kev xav, kev xav, kev xav, kev kawm, lossis kev nco. Cov menyuam yaus hnub nyoog qis dua 4 xyoos uas tau txais kev kho mob ntxhias rau lub hlwb muaj kev pheej hmoo siab dua los ntawm cov teebmeem no.

• Kab mob qog thib ob (hom qog nqaij hlav tshiab) lossis lwm yam mob, xws li mob qog hlwb, mob qog mob cancer, mob ntshav myeloid, thiab mob myelodysplastic.

Qee qhov cuam tshuam tom qab tuaj yeem kho lossis tswj tau. Nws yog ib qho tseem ceeb nrog kws kho mob tham nrog koj tus menyuam tus kws kho mob hais txog qhov tshwm sim tuaj yeem tshwm sim los ntawm qee qhov kev kho mob. Saib cov ntsiab lus hais txog Txoj Kev Pov Hwm Li Cas Rau Kev Kho Mob Kom Menyuam Khej Me.

Kev kho mob ntawm menyuam yaus TXHUA feem ntau muaj peb theem.

Kev kho mob ntawm menyuam yaus TXHUA YAM tau ua nyob rau hauv theem:

• Kev Tshawb Nrhiav Tawm: Qhov no yog thawj theem ntawm kev kho. Lub hom phiaj yog tua cov hlwb mob ntshav hauv cov ntshav thiab hlwb pob txha. Qhov no tso qhov leukemia rau hauv kev zam txim.

• Kev tswj / ua kom nruj: Qhov no yog theem ob ntawm kev kho. Nws pib thaum lub ntshav ntuag ntshav hauv kev kho mob. Lub hom phiaj ntawm kev sib koom ua ke / ua tiav ntau ntxiv yog los tua cov qog ntshav uas tseem nyob hauv lub cev thiab tuaj yeem ua rau rov huam dua.

• Kev Txij Nkawm: Qhov no yog theem peb ntawm kev kho. Lub hom phiaj yog tua cov qog ntshav uas tseem tshuav uas yuav rov ua haujlwm thiab ua kom rov huam tuaj. Feem ntau qhov kev kho mob cancer tau muab rau hauv qis dua qis dua li cov tau siv thaum lub sijhawm kev kho mob induction thiab consolidation / intensification theem. Kev tsis noj tshuaj raws li kws kho mob tau hais tseg thaum kho kho yuav ua rau muaj feem ntau tus mob cancer yuav rov qab los. Qhov no tseem hu ua theem txuas ntxiv.

Plaub hom kev kho mob raug siv:

Kws khomob

Kev siv tshuaj kho mob yog kev kho mob cancer uas siv cov tshuaj los txwv kev loj hlob ntawm cov qog nqaij hlav cancer, los ntawm kev tua cov qog lossis txwv tsis pub faib. Thaum cov tshuaj tua kab mob noj los ntawm qhov ncauj lossis txhaj rau hauv txoj hlab ntshav lossis leeg, cov tshuaj nkag mus rau cov ntshav thiab tuaj yeem mus txog rau cov qog nqaij hlav ntshav thoob plaws lub cev (kev kho mob tshuaj thev naus laus zis). Thaum cov kws kho mob tso tshuaj rau ncaj qha mus rau cov kua dej cerebrospinal (intrathecal), ib qho khoom hauv nruab nrog cev, lossis lub cev lub cev xws li lub plab, cov tshuaj feem ntau cuam tshuam rau cov qog nqaij hlav cancer hauv thaj chaw ntawd (kev kho mob hauv cheeb tsam). Kev siv tshuaj sib xyaw ua ke yog kev kho mob siv ntau dua ib qho tshuaj anticancer.

Txoj hauv kev siv tshuaj kho mob yuav muab nyob ntawm pawg menyuam qhov phom sij. Cov menyuam yaus uas muaj kev phom sij TXHUA tau txais ntau cov tshuaj anticancer thiab ntau dua cov tshuaj anticancer ntau dua li cov menyuam yaus uas muaj feem TXHUA YAM. Kev siv tshuaj rau hauv nruab nrog cev yuav siv los kho cov menyuam yaus TXHUA YAM uas tau kis, lossis yuav kis mus rau lub hlwb thiab tus txha caj qaum.

Saib Cov Tshuaj Pom Zoo rau Mob Ntshav Siab Rau Tus Mob Qog Kom Zoo rau cov lus qhia ntxiv.

Kev siv hluav taws xob

Kev xoo hluav taws xob yog kev kho mob cancer uas siv hluav taws xob xoo hluav taws xob loj lossis lwm yam hluav taws xob tua ntau los tua cov qog nqaij hlav cancer lossis ua kom lawv loj tuaj. Muaj ob txoj kev kho hluav taws xob:

• Kev siv hluav taws xob sab nraud siv lub tshuab sab nraud lub cev xa hluav taws xob mus rau cov kabmob.

• Kev kho hluav taws xob sab hauv yog siv cov tshuaj pleev hluav taws xob kaw hauv cov koob, noob, xov hlau, lossis cov paws menyuam uas tso ncaj qha mus rau lossis ze ntawm cov qog nqaij hlav cancer.

Txoj hauv kev siv hluav taws xob kho yog muab nyob ntawm hom mob qog ntshav kho. Kev kho hluav taws xob sab nraud tuaj yeem siv kho menyuam yaus TXHUA tus uas tau kis, lossis kis mus rau lub hlwb, tus txha caj qaum, lossis noob qes. Nws kuj tseem siv tau los npaj cov pob txha pob txha rau pob khoom hauv lub cev.

Siv tshuaj tua kabmob nrog qog cell hloov ntshav

Kev siv tshuaj kho mob thiab qee zaum tag nrho lub cev tiv thaiv kabmob tau muab tua cov kabmob kheesxaws. Cov kab mob noj qab haus huv, suav nrog cov qe tsim cov ntshav, kuj raug rhuav tshem los ntawm kev kho mob qog noj ntshav. Kev hloov ntawm qia yog kev kho mob los hloov cov qe tsim cov qe ntshav. Cov qia hlwb (cov qe ntshav tsis txaus) raug tshem tawm los ntawm cov ntshav lossis pob txha mob ntawm tus neeg mob lossis tus neeg pub ntshav thiab raug khov thiab khaws cia. Tom qab tus neeg mob ua tiav kev kho mob tshuaj thiab tshuaj kho hluav taws xob, lub qia hlwb raug yaj thiab muab rov qab rau tus neeg mob los ntawm kev hla tshuaj. Cov qog ntshav qog ua kom loj hlob mus rau (thiab txum tim) lub cev cov ntshav.

Kev hloov cov qog ntawm tes yog tsis tshua siv los ua kev kho rau menyuam yaus thiab tub ntxhais hluas nrog TAG NRHO. Nws yog siv ntau dua li ib feem ntawm kev kho mob rau TXHUA tus mob rov qab (rov qab los tom qab kev kho mob).

Saib Cov Tshuaj Pom Zoo rau Mob Ntshav Siab Rau Tus Mob Qog Kom Zoo rau cov lus qhia ntxiv.

Qia cell hloov. (Kauj Ruam 1): Ntshav tau txais los ntawm cov leeg ntshav hauv caj npab ntawm tus neeg pub ntshav. Cov ntshav ntws dhau los ntawm lub tshuab uas tshem cov qia. Tom qab ntawd cov ntshav xa rov qab rau tus neeg pub ntshav los ntawm txoj hlab ntsha hauv lwm sab caj npab. (Kauj Ruam 2): Tus neeg mob tau txais tshuaj kho mob los tua cov qe tsim cov ntshav. Tus neeg mob yuav tau txais kev kho mob hluav taws xob (tsis qhia). (Kauj Ruam 3): Tus neeg mob tau txais cov qia hlwb los ntawm txoj raj tso rau hauv cov hlab ntshav hauv siab.

Cov hom phiaj kho

Cov hom phiaj kho yog txoj kev kho mob uas siv tshuaj lossis lwm yam tshuaj los txheeb xyuas thiab tua cov kabmob kheesxaws tshwj xeeb yam tsis raug mob hauv hlwb. Nws muaj ntau ntau hom kev kho kom haum:

• Tyrosine kinase inhibitors (TKIs) yog cov hom phiaj kho tshuaj uas thaiv cov enzyme, tyrosine kinase, uas ua rau cov qia hlwb ua cov ntshav dawb ntau lossis cov ntshav tawg ntau dua li lub cev xav tau. Imatinib mesylate yog TKI siv rau hauv kev kho mob ntawm cov menyuam yaus nrog Philadelphia chromosome – positive TXHUA. Dasatinib thiab ruxolitinib yog TKIs uas tau kawm hauv kev kho mob tshiab uas muaj kev pheej hmoo siab TAG NRHO.

• Monoclonal antibody therapy yog kev kho mob qog noj ntshav uas siv cov tshuaj pleev rau hauv qhov chaw kuaj, los ntawm ib hom kab mob tiv thaiv kab mob hauv lub cev. Cov tshuaj tiv thaiv no tuaj yeem txheeb xyuas cov tshuaj ntawm qog nqaij hlav cancer lossis cov khoom qub uas tuaj yeem pab ua kom cov cell mob qog noj ntshav. Cov tshuaj tiv thaiv txuas rau cov tshuaj thiab tua cov qog nqaij hlav cancer, thaiv lawv qhov kev loj hlob, lossis txwv tsis pub nthuav tawm. Cov kab mob monoclonal yog muab los ntawm kev lis ntshav. Lawv yuav raug siv nyob ib leeg lossis nqa tshuaj, co toxins, lossis khoom siv hluav taws xob ncaj qha mus rau qog nqaij hlav cancer. Blinatumomab thiab inotuzumab yog cov tshuaj tiv thaiv kab mob monoclonal tau kawm hauv kev kho mob ntawm refractory thaum yau TXHUA.

• Proteasome inhibitor txoj kev kho yog ib hom kev kho mob uas cuam tshuam rau kev txiav txim ntawm cov proteasomes hauv qog hlwb. Proteasomes tshem tawm cov protein tsis tas yuav los ntawm lub cell. Thaum cov proteasomes raug thaiv, cov protein ua haujlwm hauv lub cell thiab tuaj yeem ua rau tus kabmob kheesxaws tuag. Bortezomib yog ib hom kev tiv thaiv proteasome inhibitor kho tau siv los kho mob rov zoo li tus me nyuam TXHUA.

Cov hom tshiab ntawm cov hom phiaj tshiab tseem tau muab coj los kawm hauv kev kho mob menyuam yaus TAG NRHO.

Saib Cov Tshuaj Pom Zoo rau Mob Ntshav Siab Rau Tus Mob Qog Kom Zoo rau cov lus qhia ntxiv.

Txoj kev kho yog muab los tua cov qog ntshav uas tau kis lossis yuav kis mus rau lub hlwb, tus txha nqaj qaum, lossis cov noob qes.

Kev kho los tua cov ntshav mob leukemia los yog tiv thaiv kom tsis txhob muaj cov kab mob ntshav siab rau lub hlwb thiab tus txha caj qaum (cov hlab hlwb hauv nruab nrab; CNS) yog hu ua CNS-Direct therapy. Kev siv tshuaj kho mob yuav siv los kho cov qog ntshav uas tau kis, lossis yuav kis mus rau lub hlwb thiab tus txha caj qaum. Vim tias cov tshuaj muaj kuab tshuaj ua kom zoo yuav tsis ncav cuag cov qog ntshav hauv CNS, cov hlwb tau nkaum hauv CNS. Kev siv tshuaj kho lub cev rau cov tshuaj lossis cov tshuaj kho mob kom ntau dua qub (rau hauv cov kua dej ua kom hlab ntshav) tuaj yeem mus txog rau cov ntshav muaj qog ntshav hauv CNS. Qee zaum kev kho hluav taws xob sab nraud rau lub hlwb kuj tseem tau muab.

Intrathecal kev siv tshuaj kho mob. Cov tshuaj anticancer tau txhaj rau hauv qhov chaw intrathecal, uas yog qhov chaw khaws cov tshuaj cerebrospinal kua (CSF, qhia xiav). Muaj ob txoj hauv kev los ua qhov no. Ib txoj kev, qhia nyob rau sab saum toj ntawm daim duab, yog txhaj cov tshuaj mus rau hauv Ommaya lub taub dej (lub thawv uas muaj cov dome uas tau tso rau hauv tawv taub hau thaum phais mob; nws tuav cov tshuaj thaum lawv ntws los ntawm lub raj me me rau hauv lub hlwb. )). Lwm txoj kev, qhia nyob rau hauv qab seem ntawm daim duab, yog kom txhaj cov tshuaj ncaj qha rau hauv CSF hauv ntu qis ntawm pob txha caj qaum, tom qab thaj chaw me me ntawm sab nraub qaum yog loog

Cov kev kho mob no tau ntxiv rau hauv kev kho mob uas tau siv los tua cov qog ntshav hauv lub cev. Txhua tus menyuam nrog TXHUA tau txais kev kho nrog CNS-raws kev kho mob txhawm rau ua kev kho mob thiab tiv thaiv kev mob kom zoo ntxiv thiab qee zaum thaum kho kho.

Yog tias cov hlwb mob leukemia kis mus rau cov noob qes, kev kho mob suav nrog kev txhaj tshuaj ntawm lub cev siab heev thiab qee zaum siv tshuaj tua hluav taws xob.

Cov hom kev kho mob tshiab tau raug sim hauv qhov kev sim kho mob.

Tshooj lus kawg piav txog kev kho mob uas tau kawm hauv kev sim tshuaj. Nws yuav tsis hais txog txhua txoj kev kho tshiab tau kawm. Cov ntaub ntawv hais txog kev sim kho mob muaj nyob rau ntawm NCI lub vev xaib.

Chimeric antigen receptor (CAR) Kev Kho Mob T-cell

CAR T-cell txoj kev kho yog hom tshuaj tiv thaiv kev hloov pauv ntawm tus neeg mob lub hlwb T (ib hom kab mob tiv thaiv kab mob) yog li lawv yuav tawm tsam qee cov protein nyob rau ntawm qog nqaij hlav. T qog noj tau los ntawm tus neeg mob thiab cov receptors tshwj xeeb ntxiv rau lawv nto nyob hauv chav kuaj. Cov hloov pauv hauv hlwb yog hu ua chimeric antigen receptor (CAR) T cell. Lub hlwb T hlwb raug loj hlob hauv chav kuaj thiab muab rau tus neeg mob los ntawm kev ua txhaum. Cov hlwb T ua rau cov neeg mob cov ntshav ntau ntau thiab tua cov qog nqaij hlav cancer. Kev kho mob T-cell yog tau kawm hauv kev kho mob menyuam yaus TXHUA YAM tau rov ua mob dua (rov qab los) zaum ob.

Kev kho T-cell kho mob. Ib hom kev kho mob uas tus neeg lub hlwb T (ib hom mob tiv thaiv kab mob) tau hloov pauv hauv chav kuaj tshuaj vim li ntawd lawv yuav khi rau cov qog nqaij hlav cancer thiab tua lawv. Cov ntshav los ntawm cov leeg ntshav hauv tus neeg mob txhais caj npab ntws los ntawm lub raj xa mus rau lub tshuab apheresis (tsis qhia tawm), uas tshem tawm cov qe ntshav dawb, suav nrog T cell, thiab xa cov ntshav rov qab rau tus neeg mob. Tom qab ntawd, lub noob rau tshwj xeeb receptor hu ua chim chim antigen receptor (CAR) muab tso rau hauv T cell hauv chav kuaj. Ntau lab ntawm lub hlwb T hlwb raug loj hlob hauv chav kuaj thiab tom qab ntawd muab rau tus neeg mob los ntawm infusion. Cov hlwb T ua ke muaj peev xwm khi rau ib tus antigen ntawm cov kabmob kheesxaws thiab tua lawv.

Cov neeg mob yuav xav txog kev sim kho mob.

Txog qee tus neeg mob, koom nrog kev sim kho mob yuav yog txoj kev xaiv zoo tshaj plaws. Cov chaw kuaj mob yog ib feem ntawm cov txheej txheem tshawb mob qog noj ntshav. Cov chaw kho mob tau sim ua kom pom tias kev kho mob qog noj ntshav tshiab muaj kev nyab xeeb thiab zoo dua lossis zoo dua cov qauv tshuaj.

Ntau yam ntawm cov qauv kev kho mob qog noj ntshav niaj hnub no yog los ntawm cov kev tshawb fawb kab mob thaum ntxov. Cov neeg mob uas koom nrog kev sim kho mob tuaj yeem tau txais cov qauv kev kho mob lossis ua thawj zaug tau txais kev kho mob tshiab.

Cov neeg mob uas koom nrog kev sim kho mob kuj pab txhim kho txoj kev kho mob qog nqaij hlav yav tom ntej. Txawm hais tias kev sim tshuaj sim tsis ua rau muaj kev kho mob tshiab, lawv feem ntau teb cov lus nug tseem ceeb thiab pab txav kev tshawb fawb tom ntej.

Cov neeg mob tuaj yeem nkag mus kuaj mob ua ntej, sijhawm, lossis tom qab pib kho mob qog noj ntshav.

Qee qhov kev sim tshuaj tsuas yog suav nrog cov neeg mob uas tseem tsis tau txais kev kho mob. Lwm txoj kev sim sim cov kev kho mob rau cov neeg mob uas mob qog noj qab tsis tau zoo dua. Kuj tseem muaj cov kev sim tshuaj kuaj mob uas sim txoj kev tshiab los txwv qog noj ntshav kom tsis txhob mob ntxiv (rov qab los) lossis txo kev phiv los ntawm kev kho mob qog noj.

Cov chaw kuaj mob tau tshwm sim nyob rau ntau lub tebchaws. Cov ntaub ntawv hais txog kev sim kho mob uas tau txhawb nqa los ntawm NCI tuaj yeem nrhiav pom ntawm NCI cov chaw kuaj mob tshawb nrhiav lub vev xaib. Cov chaw kuaj mob txhawb nqa los ntawm lwm cov koomhaum tuaj yeem nrhiav pom ntawm ClinicalTrials.gov lub vev xaib.

Tej zaum yuav tau ua raws li kev ntsuam xyuas.

Qee qhov kev ntsuas mob uas tau ntsuas los kuaj mob qog noj ntshav lossis kom pom tias theem mob cancer yuav rov qab ua dua. Qee qhov kev ntsuas yuav rov ua qhov qub txhawm rau kom pom tias qhov kev kho mob ua haujlwm li cas. Cov kev txiav txim siab hais txog seb puas yuav txuas ntxiv, hloov, lossis tsum tsis mus kho yuav ua raws cov txiaj ntsig ntawm cov kev ntsuas no.

Qee qhov kev sim yuav txuas ntxiv ua ib zaug dhau ib zaug tom qab kho tas. Qhov tshwm sim ntawm cov kev sim no tuaj yeem qhia tau yog tias koj tus menyuam tus mob tau hloov lossis yog tus kabmob tau mob ntxiv (rov qab los). Qee qhov kev ntsuas no qee zaum hu ua kev kuaj mob rov qab lossis mus kuaj mob.

Mob pob txha txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau lub sijhawm txhua theem ntawm kev kho mob kom pom tseeb tias kev kho mob ua haujlwm tau zoo npaum li cas.

Cov Kev Xaiv Kho rau Menyuam Yaus Kho Mob Ntshav Qab Zib Lem Cov Mob Ntshav Qab Zib

Hauv Tshooj Lus no

• Cov Koob Tshuaj Ntsuam Thaum Menyuam Yaus Tso Cia Li Mob Rau Cov Mob Ntshav Qab Zib Loj (Cov Qauv Ntsuas)

• Cov Koob Tshuaj Ntsuam Xyuas Thaum Menyuam Yaus Mob Mob Loj Cov Ntshav Qab Zib Lem Ntshav Qab Zib (Muaj Kev Nyuaj Siab)

• Cov Koob Tshuaj Ntsuam Thaum Menyuam Yaus Tso Cia Li Mob Ntshav Qab Zib (Mob Heev)

• Cov Koob Tshuaj Ntsuam Xyuas Thaum Menyuam Yaus Mob Mob Loj Cov Ntshav Qab Zib Lem (Cov Pab Pawg Tshwj Xeeb)

• T-cell thaum lub caij cov neeg cov ntshav tsis pom qab mob

• Cov Menyuam mos nrog TXHUA

• Cov menyuam hnub nyoog 10 xyoo thiab tshaj saud thiab cov hluas nrog TAG NRHO

• Philadelphia chromosome – zoo TXHUA

• Kho Chaw Thaum Menyuam Yaus Acute Lymphoblastic Leukemia

• Cov mob rov ua mob me thaum mob caj dab mob ntsws mob ntshav dawb

Yog xav paub txog cov kev kho mob uas teev rau hauv qab no, saib hauv Cov Lus Qhia Kev Xaiv Kev Xaiv.

Cov Koob Tshuaj Ntsuam Thaum Menyuam Yaus Tso Cia Li Mob Rau Cov Mob Ntshav Qab Zib Loj (Cov Qauv Ntsuas)

Cov kev kho mob ntawm cov qauv kev pheej hmoo rau cov menyuam yaus thaum mob lymphoblastic leukemia (TAG NRHO) thaum lub sijhawm tshem tawm, ua kom sib txuam / sib zog, thiab txij li cov sijhawm ib txwm suav nrog kev kho mob sib xyaw. Thaum cov menyuam yaus nyob rau hauv kev tshem tawm tom qab kev kho mob induction kev kho mob, ib txoj kev hloov qia cell siv qia hlwb los ntawm tus neeg pub. Thaum cov menyuam tsis nyob rau hauv kev zam txim tom qab kev tshem tawm induction txoj kev kho, kev kho ntxiv feem ntau yog tib txoj kev kho mob rau cov menyuam yaus uas muaj kev phom sij TXHUA.

Intrathecal kev siv tshuaj kho mob tau muab rau kev tiv thaiv cov mob hlwb leukemia mus rau lub hlwb thiab tus txha caj qaum.

Cov kev kho mob tau kawm hauv kev soj ntsuam kuaj mob rau cov txheej txheem pheej hmoo TXHUA suav nrog kev kho tshuaj tshiab.

Siv peb qhov kev tshawb nrhiav kab mob hauv tsev kho mob kom pom qhov NCI-txhawb nqa kev mob qog nqaij hlav uas pom zoo rau cov neeg mob. Koj tuaj yeem tshawb xyuas cov kev sim raws li hom mob cancer, hnub nyoog ntawm tus neeg mob, thiab qhov chaw uas sim kev sim. Cov ncauj lus dav dav txog kev sim kho mob kuj muaj.

Cov Koob Tshuaj Ntsuam Xyuas Thaum Menyuam Yaus Mob Mob Loj Cov Ntshav Qab Zib Lem Ntshav Qab Zib (Muaj Kev Nyuaj Siab)

Cov kev kho mob ntawm cov me nyuam muaj feem yuav mob siab ntsws mob ntshav siab ntsws (TXHUA) thaum lub sijhawm tshem tawm, sib sau ua ke / sib zog, thiab tswj cov theem ib txwm suav nrog kev kho mob sib xyaw. Cov menyuam yaus nyob rau hauv qhov kev pheej hmoo siab TXHUA pawg tau muab tshuaj ntau rau cov tshuaj anticancer thiab siab dua ntawm cov tshuaj anticancer, tshwj xeeb tshaj yog thaum sib koom ua ke / sib zog, ntau dua li cov menyuam yaus hauv pawg qauv.

Muab tshuaj rau hauv nruab nrog cev thiab tshuaj tua kabmob rau cov menyuam yaus txhawm rau muab kev tiv thaiv lossis kho kev sib kis ntawm cov ntshav muaj ntshav rau lub hlwb thiab tus txha caj qaum. Qee zaum siv hluav taws xob kho rau lub hlwb kuj tseem tau muab.

Cov kev kho mob tau kawm hauv kev soj ntsuam kuaj mob rau qhov muaj pheej hmoo TXHUA suav nrog kev kho cov tshuaj tua kab mob tshiab nrog lossis tsis tsom kho lossis hloov qia hlwb.

Siv peb qhov kev tshawb nrhiav kab mob hauv tsev kho mob kom pom qhov NCI-txhawb nqa kev mob qog nqaij hlav uas pom zoo rau cov neeg mob. Koj tuaj yeem tshawb xyuas cov kev sim raws li hom mob cancer, hnub nyoog ntawm tus neeg mob, thiab qhov chaw uas sim kev sim. Cov ncauj lus dav dav txog kev sim kho mob kuj muaj.

Cov Koob Tshuaj Ntsuam Thaum Menyuam Yaus Tso Cia Li Mob Ntshav Qab Zib (Mob Heev)

Cov kev kho mob ntawm qhov mob nyhav childhood txaus ntshai menyuam yaus mob qog ntshav ntau (TXHUA) thaum lub sijhawm tshem tawm, sib sau ua ke / sib zog, thiab tswj cov theem ib txwm suav nrog kev siv tshuaj sib xyaw. Cov menyuam yaus nyob rau qhov kev pheej hmoo heev ALL TXHUA pawg tau muab cov tshuaj anticancer ntau dua li cov menyuam yaus hauv cov pab pawg uas muaj feem ntau. Nws tsis paub meej tias kev hloov qia ntawm tes thaum pib kho thawj zaug yuav pab tau tus menyuam nyob ntev li cas.

Muab tshuaj rau hauv nruab nrog cev thiab tshuaj tua kabmob rau cov menyuam yaus txhawm rau muab kev tiv thaiv lossis kho kev sib kis ntawm cov ntshav muaj ntshav rau lub hlwb thiab tus txha caj qaum. Qee zaum siv hluav taws xob kho rau lub hlwb kuj tseem tau muab.

Cov kev kho mob uas tau kawm hauv kev soj ntsuam kab mob kev phom sij rau qhov pheej hmoo heev include TXHUA suav nrog kev kho cov tshuaj siv tshuaj tshiab nrog lossis tsis tau kho.

Siv peb qhov kev tshawb nrhiav kab mob hauv tsev kho mob kom pom qhov NCI-txhawb nqa kev mob qog nqaij hlav uas pom zoo rau cov neeg mob. Koj tuaj yeem tshawb xyuas cov kev sim raws li hom mob cancer, hnub nyoog ntawm tus neeg mob, thiab qhov chaw uas sim kev sim. Cov ncauj lus dav dav txog kev sim kho mob kuj muaj.

Cov Koob Tshuaj Ntsuam Xyuas Thaum Menyuam Yaus Mob Mob Loj Cov Ntshav Qab Zib Lem (Cov Pab Pawg Tshwj Xeeb)

T-cell thaum lub caij cov neeg cov ntshav tsis pom qab mob

Kev kho mob ntawm T-cell thaum yau mob lymphoblastic leukemia (TAG NRHO) thaum lub sijhawm tshem tawm, muab tso ua ke / sib zog, thiab tswj cov theem ib txwm suav nrog kev kho mob sib xyaw. Cov menyuam yaus uas muaj T-cell TXHUA tseem muab cov tshuaj anticancer ntau dua thiab txhaj tshuaj ntau dua ntawm cov tshuaj anticancer dua cov menyuam yaus hauv cov pab pawg tshiab uas muaj cov cim soj ntsuam.

Muab tshuaj rau hauv nruab nrog cev thiab tshuaj tua kabmob rau cov leeg txhawm rau txhawm rau tiv thaiv kev kis mob ntawm cov qog ntshav ntshav mus rau lub hlwb thiab tus txha caj qaum. Qee zaum siv hluav taws xob kho rau lub hlwb kuj tseem tau muab.

Cov kev kho mob tau kawm nyob rau hauv kev sim kho mob rau T-cell TXHUA suav nrog cov tshuaj anticancer tshiab thiab kev kho cov tshuaj tua kab mob nrog lossis tsis tau kho hom phiaj.

Cov Menyuam mos nrog TXHUA

Kev kho mob ntawm menyuam mos nrog TXHUA thaum kev tshem tawm kev tso cia, sib ntxiv / sib zog, thiab txij nkawm thawm lub sijhawm ib txwm suav nrog kev siv tshuaj kho mob. Cov menyuam mos mob mob TXHUA tau muab cov tshuaj anticancer sib txawv thiab ntau dua koob tshuaj anticancer ntau dua li cov menyuam yaus 1 xyoos thiab laus dua hauv cov pab pawg pheej hmoo. Nws tsis paub meej tias kev hloov qia ntawm tes thaum pib kho thawj zaug yuav pab tau tus menyuam nyob ntev li cas.

Muab tshuaj rau hauv nruab nrog cev thiab tshuaj tua kabmob rau cov leeg txhawm rau txhawm rau tiv thaiv kev kis mob ntawm cov qog ntshav ntshav mus rau lub hlwb thiab tus txha caj qaum.

Cov kev kho mob tau kawm hauv kev sim kho mob rau cov menyuam mos nrog TXHUA suav nrog kev kho mob rau menyuam mos nrog qee yam hloov pauv gene.

Cov menyuam hnub nyoog 10 xyoo thiab tshaj saud thiab cov hluas nrog TAG NRHO

Cov kev kho mob ntawm TXHUA rau cov menyuam yaus thiab cov hluas (10 xyoo thiab laus dua) thaum muaj kev tshem tawm, ua kom nkag siab / sib zog, thiab txij li cov sijhawm ib txwm suav nrog kev kho mob sib xyaw. Cov menyuam yaus 10 xyoo thiab rov saud thiab cov hluas nrog TAG NRHO muaj cov tshuaj anticancer ntau dua thiab txhaj tshuaj ntau dua ntawm cov tshuaj anticancer ntau dua li cov menyuam yaus hauv cov pab pawg uas phom sij.

Muab tshuaj rau hauv nruab nrog cev thiab tshuaj tua kabmob rau cov leeg txhawm rau txhawm rau tiv thaiv kev kis mob ntawm cov qog ntshav ntshav mus rau lub hlwb thiab tus txha caj qaum. Qee zaum siv hluav taws xob kho rau lub hlwb kuj tseem tau muab.

Cov kev kho mob tau kawm hauv cov kev sim kho mob rau cov menyuam yaus 10 xyoo thiab laus dua thiab cov hluas nrog TAG NRHO suav nrog cov tshuaj tiv thaiv kab mob tshiab thiab kev kho cov tshuaj tua kab mob nrog lossis tsis tau kho hom phiaj.

Philadelphia chromosome – zoo TXHUA

Kev kho mob ntawm Philadelphia chromosome – kev ua kom zoo thaum yau TXHUA lub sijhawm kev tshem tawm, nkag ua ke / ua kom nruj ntxiv, thiab cov theem txij nkawm tuaj yeem suav nrog cov hauv qab no:

• Kev siv tshuaj khomob sib ntxiv thiab lub hom phiaj kho nrog tyrosine kinase inhibitor (imatinib mesylate) nrog lossis tsis cia qia hloov qog siv qia hlwb los ntawm tus neeg pub.

Cov kev kho mob tau kawm nyob rau hauv kev sim kho mob rau Philadelphia chromosome – kev muaj menyuam yaus zoo TXHUA suav nrog kev kho tshiab ntawm cov hom phiaj kho (imatinib mesylate) thiab kev siv tshuaj ua ke nrog lossis tsis muaj hloov qia.

Siv peb qhov kev tshawb nrhiav kab mob hauv tsev kho mob kom pom qhov NCI-txhawb nqa kev mob qog nqaij hlav uas pom zoo rau cov neeg mob. Koj tuaj yeem tshawb xyuas cov kev sim raws li hom mob cancer, hnub nyoog ntawm tus neeg mob, thiab qhov chaw uas sim kev sim. Cov ncauj lus dav dav txog kev sim kho mob kuj muaj.

Kho Chaw Thaum Menyuam Yaus Acute Lymphoblastic Leukemia

Nws tsis muaj ib txoj hauv kev kho rau kev kho mob kom rov zoo li menyuam yaus thaum mob ntsws thiav ntshav siab ntsws (Txhua).

Kev kho mob ntawm refractory thaum yau TXHUA yam yuav suav nrog cov hauv qab no:

• Cov hom phiaj kho (blinatumomab lossis inotuzumab).

• Chimeric antigen receptor (CAR) Kev Kho Mob T-cell.

Cov mob rov ua mob me thaum mob caj dab mob ntsws mob ntshav dawb

Txoj kev kho mob rau cov me nyuam yaus mob los ua mob rau cov leeg ntshav (TUB DAWB) uas rov qab los ntawm cov hlwb pob txha tej zaum yuav muaj li hauv qab no:

• Kev kho tshuaj sib xyaw nrog lossis tsis tau tsom mus rau siv kho (bortezomib).

• Kev hloov ntawm qia ntawm tes, siv cov qia hlwb los ntawm kev pub.

Kev kho tus mob uas mob rov qab rau tus me nyuam cov mob ntshav thiav ntshav (TXHUA) uas rov qab sab sab pob txha tuaj yeem suav nrog cov hauv qab no:

• Kev siv tshuaj kho cov mob hlwb thiab tshuaj tua kabmob nrog kev kho mob hluav taws xob rau lub hlwb thiab / lossis tus txha caj qaum rau mob qog nqaij hlav uas rov qab rau lub hlwb thiab tus txha caj qaum xwb.

• Kev sib txuas ua ke ntawm cov tshuaj thiab hluav taws xob kho rau cov qog ntshav uas rov qab los hauv noob qes tsuas.

• Kev hloov qia rau qog nqaij hlav rau mob qog noj uas tau rov muaj tshwm sim hauv lub hlwb thiab / lossis tus txha nqaj qaum.

Qee qhov kev kho mob tau kawm hauv chaw soj ntsuam kuaj mob rau cov menyuam rov mob taus TXHUA suav nrog:

• Ib qho kev tswj hwm tshiab ntawm kev sib xyaw nrog kev siv tshuaj thiab kho lub hom phiaj (blinatumomab).

• Ib yam tshiab ntawm kev siv tshuaj khomob.

• Chimeric antigen receptor (CAR) Kev Kho Mob T-cell.

Siv peb qhov kev tshawb nrhiav kab mob hauv tsev kho mob kom pom qhov NCI-txhawb nqa kev mob qog nqaij hlav uas pom zoo rau cov neeg mob. Koj tuaj yeem tshawb xyuas cov kev sim raws li hom mob cancer, hnub nyoog ntawm tus neeg mob, thiab qhov chaw uas sim kev sim. Cov ncauj lus dav dav txog kev sim kho mob kuj muaj.

Yog Xav Paub Ntxiv Txog Cov Menyuam Yaus Mob Ntshav Qab Zib Lem Cov Mob Ntshav Qab Zib

Yog xav paub ntau ntxiv los ntawm National Cancer Institute txog kev mob qog ua ntshav rau menyuam yaus, saib cov hauv qab no:

• Sib Tham Tomography (CT) Kev Kuaj thiab Cancer

• Cov Tshuaj Pom Zoo rau Cov Mob Ntshav Qab Zib Mob Lymphoblastic

• Ntshav-Ua Rau Lub Cev Hloov Pauv

• Hom Kab Mob Kuaj Mob Cancer

Yog xav paub ntau ntxiv txog kev mob qog noj ntshav thaum tseem yau thiab lwm yam kev qhia txog mob qog noj ntshav, saib cov hauv qab no:

• Txog Mob Cancer

• Kev Menyuam Kab Menyuam Kiag

• CureSearch rau Cov Menyuam Txoj Kev Mob Cancer

• Qhov Zoo Los Ntawm Txoj Kev Kho Mob Kheev Me Menyuam Thaum Ntxov

• Cov Hluas thiab Cov Hluas Hluas Muaj Mob Cancer

• Cov Menyuam Muaj Mob Cancer: Cov Lus Qhia rau Niam Txiv

• Mob Cancer rau Cov Menyuam thiab Cov Hluas

• Qib

• Kev Muaj Mob Cancer

• Cov Lus Nug Yuav Nug Koj Tus Kws Kho Mob txog Kab Mob Cancer

• Rau Cov Muaj Txoj Sia Nyob thiab Cov Saib Xyuas