Hom / hlwb / tus neeg mob / menyuam-astrocytoma-treament-pdq

Thaum Ntxov Ntxhuav Astrocytomas Kho (®) atTxoj Cai Kho Dua

Cov Lus Qhia Dav Dav Txog Dab Neeg Me Nyuam yaus Astrocytomas

QHOV TSEEM CEEB

• Astrocytoma thaum yau yog ib tus kab mob uas cov benign (noncancer) lossis malignant (mob qog nqaij hlav) ua rau cov nqaij hauv lub hlwb.

• Astrocytomas tej zaum yuav yog mob (tsis yog mob cancer) lossis mob hlwb (mob hlwb).

• Lub hauv nruab nrab cov hlab ntsha tswj ntau qhov haujlwm lub cev tseem ceeb.

• Cov ua kom muaj feem ntau ntawm cov hlav hlwb thaum yau tsis paub.

• Cov cim thiab tsos mob ntawm astrocytomas tsis zoo ib yam rau txhua tus menyuam.

• Kev kuaj uas kuaj xyuas lub hlwb thiab tus txha caj qaum yog siv los kuaj (pom) cov me nyuam astrocytomas.

• Astrocytomas menyuam yaus feem ntau kuaj thiab tshem tawm hauv kev phais mob.

• Qee yam cuam tshuam txog kev raug (mob rov qab) thiab txoj kev kho.

Astrocytoma thaum yau yog ib tus kab mob uas cov benign (noncancer) lossis malignant (mob qog nqaij hlav) ua rau cov nqaij hauv lub hlwb.

Astrocytomas yog qog uas pib hauv cov hlwb lub hnub qub hu ua astrocytes. Astrocyte yog ib hom ntawm glial cell. Glial cells tuav cov hlab ntsha hauv qhov chaw, nqa zaub mov thiab oxygen rau lawv, thiab pab tiv thaiv lawv los ntawm kab mob, xws li kis mob. Gliomas yog qog uas tsim los ntawm cov hlwb glial. Astrocytoma yog hom glioma.

Astrocytoma yog yam mob kheev pom muaj tseeb hauv cov me nyuam yaus. Nws tuaj yeem tsim nyob rau txhua qhov chaw hauv nruab nrab lub paj hlwb (lub hlwb thiab tus txha caj qaum).

Cov ntsiab lus xaus no yog hais txog kev kho qog uas pib astrocytes hauv lub hlwb (thawj cov qog ntshav). Metastatic hlav hlav ua npaws yog tsim los ntawm cov qog nqaij hlav cancer uas pib hauv lwm qhov ntawm lub cev thiab kis mus rau lub hlwb. Kev kho cov mob hlwb metastatic tsis tham txog ntawm no.

Kev mob qog tuaj yeem tshwm sim hauv cov menyuam yaus thiab cov neeg laus. Txawm li cas los xij, kev kho mob rau menyuam yaus yuav txawv dua li kev kho rau cov neeg laus. Saib cov lus qhia hauv hauv qab no rau cov lus qhia ntxiv txog lwm hom mob hlwb hauv cov menyuam yaus thiab cov neeg laus:

• Cov Menyuam Lub Hlwb Menyuam Hlav thiab Pob Ntse Sij Hawm Kev Kho Mob Txheej txheem cej luam

• Kev Kho Mob Loj Nruab Nrab Nruab Nrab Txheej Txheem

Astrocytomas tej zaum yuav yog mob (tsis yog mob cancer) lossis mob hlwb (mob hlwb).

Benign cov qog hlwb loj hlob thiab nias rau ntawm thaj chaw ze ntawm lub hlwb. Lawv tsis tshua kis mus rau lwm daim ntaub. Cov hlav hlav muaj hlav ntshav feem ntau yuav hlav sai thiab kis mus rau lwm cov leeg hlwb. Thaum cov qog loj tuaj rau hauv lossis nias ntawm thaj chaw ntawm lub hlwb, nws yuav nres qhov ntawd ntawm lub hlwb los ntawm kev ua haujlwm raws li nws yuav tsum ua. Ob qho tib si benign thiab malignant lub hlwb hlav tuaj yeem ua rau cov paib thiab cov tsos mob thiab yuav luag txhua tus xav tau kev kho mob.

Lub hauv nruab nrab cov hlab ntsha tswj ntau qhov haujlwm lub cev tseem ceeb.

Astrocytomas feem ntau muaj nyob rau cov chaw ntawm txoj hlab hlwb (CNS):

• Cerebrum: Qhov feem ntau ntawm lub paj hlwb, nyob rau saum toj taub hau. Cerebrum tswj kev xav, kev kawm, kev daws teeb meem, kev hais lus, kev xav, nyeem, sau thiab ua haujlwm dawb.

• Cerebellum: Qhov qis, nraub qaum ntawm lub paj hlwb (ze rau nruab nrab ntawm sab nraum qab ntawm lub taub hau). Cerebellum tswj kev txav, sib npaug, thiab kev sawv.

• Lub hlwb qia: Ntu uas txuas rau lub hlwb mus rau tus txha caj qaum, nyob rau hauv qhov qis ntawm lub paj hlwb (cia li saum toj sab nraum caj dab). Lub hlwb qia tswj ua pa, lub plawv dhia, thiab lub leeg thiab leeg nqaij siv hauv kev pom, hnov ​​lus, taug kev, tham, thiab noj mov.

• Hypothalamus: Thaj chaw nyob hauv nruab nrab ntawm lub hauv paus ntawm lub hlwb. Nws tswj lub cev kub, kev tshaib plab thiab nqhis dej.

• Visual pathway: Cov pab pawg ntawm cov leeg ntshav uas txuas lub qhov muag nrog lub hlwb.

• Txoj leeg nrob qaum: Qhov kab ntawm cov hlab ntsha uas khiav los ntawm lub hlwb qia nqes hauv plawv ntawm qhov nraub qaum. Nws yog them los ntawm peb txheej nyias ntawm daim ntaub hu ua daim nyias nyias. Lub leeg nraub qaum thiab daim nyias nyias muaj ib ncig ntawm lub pob txha caj qaum (cov pob txha qaum). Cov leeg pob txha pob txha nqa xov ntawm lub hlwb thiab lwm qhov hauv lub cev, xws li cov lus los ntawm lub hlwb kom cov leeg ua haujlwm lossis cov lus los ntawm daim tawv nqaij rau lub hlwb kom hnov ​​tau kov.

Anatomy ntawm lub hlwb. Thaj chaw supratentorial (sab qaum sab ntawm lub hlwb) muaj cov cerebrum, cov leeg ventricle thiab thib peb ventricle (nrog cerebrospinal kua qhia xiav), choroid plexus, lub caj pas pineal, hypothalamus, pituitary caj pas, thiab cov leeg. Lub posterior fossa / infratentorial thaj tsam (qhov qis dua sab qaum ntawm lub hlwb) muaj cov cerebellum, tectum, plaub ventricle, thiab lub hlwb qia (midbrain, pons, thiab medulla). Lub tentorium cais cov supratentorium los ntawm infratentorium (txoj cai vaj huam sib luag). Cov pob txha taub hau thiab pob txha caj qaum yog tiv thaiv lub hlwb thiab tus txha caj qaum (sab laug vaj huam sib luag).

Cov ua kom muaj feem ntau ntawm cov hlav hlwb thaum yau tsis paub.

Txhua yam uas ua rau koj muaj feem yuav kis tus mob yog hu ua kev pheej hmoo. Muaj qhov muaj feem yuav tsis txhais tau tias koj yuav muaj mob qog noj ntshav; tsis muaj yam txaus ntshai tsis txhais tau tias koj yuav tsis muaj mob qog noj ntshav. Tham nrog koj tus menyuam tus kws kho mob yog tias koj xav tias koj tus menyuam raug pheej hmoo. Cov kev pheej hmoo txaus ntshai rau astrocytoma suav nrog:

• Yav dhau los siv hluav taws xob kho rau lub hlwb.

• Muaj qee yam teeb meem hauv caj ces, xws li neurofibromatosis type 1 (NF1) lossis mob hnoos qeev.

Cov cim thiab tsos mob ntawm astrocytomas tsis zoo ib yam rau txhua tus menyuam.

Cov tsos mob thiab cov tsos mob nyob ntawm cov hauv qab no:

• Qhov twg cov qog ua nyob rau hauv lub hlwb lossis tus txha caj qaum.

• Qhov loj ntawm lub qog.

• Yuav sai npaum li cas cov qog hlob tuaj.

• Tus me nyuam lub hnub nyoog thiab kev loj hlob.

Cov qog ua tsis mob lossis cov tsos mob. Cov tsos mob thiab cov tsos mob yuav tshwm sim los ntawm me nyuam yaus astrocytomas lossis lwm yam mob. Nrog koj tus menyuam tus kws kho mob tham yog tias koj tus menyuam muaj tej yam hauv qab no:

• Thaum sawv ntxov mob taub hau lossis mob taub hau uas ploj mus tom qab ntuav.

• Xeev siab thiab ntuav.

• Teeb meem tsis pom kev, hnov ​​lus, thiab hais lus tsis tau.

• Poob ntawm kev tshuav thiab teeb meem taug kev.

• Ua phem sau ntawv lossis hais lus qeeb.

• Tsis muaj zog lossis hloov pauv ntawm qhov xav ntawm ib sab ntawm lub cev.

• Hnov tsaug zog txawv.

• Ntau dua lossis tsawg zog dua li ib txwm.

• Hloov ntawm tus kheej lossis tus cwj pwm.

• Qaug dab peg.

• Kev rog los sis rog tsis paub yog vim li cas.

• Nce qhov loj ntawm lub taub hau (hauv cov menyuam yaus).

Kev kuaj uas kuaj xyuas lub hlwb thiab tus txha caj qaum yog siv los kuaj (pom) cov me nyuam astrocytomas.

Cov ntawv xeem thiab txheej txheem hauv qab no yuav raug siv:

• Kev kuaj lub cev thiab keeb kwm: Kev kuaj lub cev kom kuaj xyuas cov cim ntawm kev noj qab haus huv. Qhov no suav nrog kev tshuaj xyuas cov cim ntawm tus kabmob, xws li mob pob lossis lwm yam uas zoo li txawv txawv. Cov keeb kwm ntawm tus neeg mob txoj kev noj qab haus huv thiab cov kab mob yav dhau los thiab kev kho mob tseem yuav raug coj los siv.

• Kev Tshawb Fawb (Neurological): Cov lus nug thiab ntsuas mus tshuaj xyuas lub hlwb, leeg hlwb, thiab lub paj hlwb ua haujlwm. Qhov kev kuaj xyuas kuaj ib tus neeg lub hlwb, kev sib koom ua ke, thiab kev muaj peev xwm taug kev ib txwm, thiab cov leeg nqaij, qhov zoo thiab tsis ua hauj lwm zoo npaum li cas. Qhov no kuj tseem yuav raug hu ua neuro neuro kuaj lossis qhov ntsuas ntawm neurologic.

• Kev soj ntsuam qhov muag pom: Qhov kev kuaj xyuas seb tus neeg lub zeem muag pom li cas (thaj chaw hauv cov khoom uas tuaj yeem pom). Qhov kev ntsuas no ntsuas ob lub zeem muag hauv nruab nrab (ntau npaum li cas tus neeg tuaj yeem pom thaum ntsia ncaj qha tom ntej) thiab pom kev sib luag (ntau npaum li cas ib tus neeg tuaj yeem pom hauv txhua lwm cov lus qhia thaum ntsia ncaj ncaj tom ntej). Lub qhov muag yuav kuaj ib zaug. Lub qhov muag tsis tau tshuaj ntsuam yog npog.

• MRI (sib nqus resonance duab) nrog gadolinium: Tus txheej txheem uas siv cov hlau nplaum, xov tooj cua voos, thiab lub koos pij tawj los ua cov duab ntawm cov ncauj lus kom ntxaws ntawm lub hlwb thiab tus txha caj qaum. Cov tshuaj hu ua gadolinium yog txhaj rau hauv cov leeg ntshav. Tus gadolinium sau ib puag ncig cov qog nqaij hlav cancer thiaj li ua rau lawv pom ci ntsa iab hauv daim duab. Tus txheej txheem no tseem hu ua nuclear sib nqus resonance imaging (NMRI). Qee lub sij hawm sib nqus resonance spectroscopy (MRS) tau ua thaum lub qub MRI scan los saib cov tshuaj pleev ib ce ntawm lub hlwb cov ntaub so ntswg.

Astrocytomas menyuam yaus feem ntau kuaj thiab tshem tawm hauv kev phais mob.

Yog tias cov kws kho mob xav tias yuav muaj hnub astrocytoma, tej zaum yuav kuaj ib qhov nqaij mus rau ib qhov nqaij coj los so. Rau cov qog hlav nyob rau hauv lub hlwb, ib feem ntawm pob txha taub hau raug tshem tawm thiab ib rab koob yog siv los tshem tawm cov ntaub so ntswg. Qee zaum, lub koob tau taw qhia los ntawm lub khoos phis tawm. Tus kws kho mob tawm tswv yim pom cov nqaij hauv qab lub tshuab tsom nrhiav cov qog nqaij hlav cancer. Yog tias pom cov kab mob qog noj ntshav, tus kws kho mob tuaj yeem tshem tawm cov qog ntshav ntau dua kom nyab xeeb thaum muaj kev phais tib yam. Vim tias nws tuaj yeem nyuaj los qhia qhov sib txawv ntawm ntau hom qog hlwb, koj yuav xav kom koj tus menyuam cov nqaij mos los soj ntsuam los ntawm tus kws saib xyuas mob uas muaj kev paub txog kev mob hlwb.

Craniotomy: Qhov qhib yog tsim hauv pob txha taub hau thiab ib ntu pob txha taub hau raug tshem tawm txhawm rau txhawm rau qhia qee feem ntawm lub hlwb.

Kev ntsuam xyuas hauv qab no tuaj yeem ua rau ntawm daim ntaub uas tau muab tshem tawm:

• Immunohistochemistry: Kev sim tshuaj uas siv tshuaj tiv thaiv kab mob los tiv thaiv qee yam antigens (ntaus cim) hauv cov qauv ntawm tus neeg mob lub cev. Cov tshuaj tiv thaiv kab mob feem ntau yog txuas nrog qhov enzyme lossis fluorescent zas. Tom qab cov tshuaj tiv thaiv txuas mus rau ib qho antigen tshwj xeeb hauv cov qauv ntaub so ntswg, cov enzyme lossis zas xim raug qhib, thiab cov antigen tuaj yeem pom hauv qab lub tshuab tsom. Hom kev kuaj ntshav no siv los pab kuaj mob qog nqaij hlav thiab pab qhia ib hom mob cancer los ntawm lwm hom mob cancer. Kev kuaj MIB-1 yog ib hom tshuaj tiv thaiv kabmob (immunohistochemistry) uas kuaj cov qog nqaij hlav rau cov antigen hu ua MIB-1. Qhov no yuav ua kom pom sai npaum li cas lub qog loj hlob tuaj.

Qee zaum cov qog hlav ua rau hauv qhov chaw uas ua rau lawv tshem tawm nyuaj. Yog tias tshem lub qog tuaj yeem ua rau mob hnyav ntawm lub cev, lub siab lossis lossis teeb meem kev kawm, yuav tsum tau kuaj ib lub cev thiab mam li siv tshuaj kho ntau dua tom qab kuaj.

Cov menyuam yaus uas muaj NF1 yuav ua tau lub astrocytoma qib qis hauv thaj chaw ntawm lub hlwb uas tswj kev pom kev thiab tsis xav siv me me. Yog tias cov qog tsis txuas ntxiv lossis cov tsos mob tsis tshwm sim, kev phais mob tshem tawm cov qog yuav tsis tas yuav tsum tau siv.

Qee yam cuam tshuam txog kev raug (mob rov qab) thiab txoj kev kho.

Qhov raug (sij hawm rov qab los) thiab kev xaiv kho nyob ntawm cov hauv qab no:

• Txawm hais tias lub qog noj ntshav qis los yog qib qis astrocytoma.

• Qhov twg cov qog tau tsim nyob rau hauv CNS thiab yog tias nws tau kis mus rau cov ntaub so ntswg ze lossis rau lwm qhov chaw ntawm lub cev.

• Yuav sai npaum li cas cov qog tau loj hlob.

• Tus menyuam hnub nyoog.

• Seb puas muaj mob hlwb nyob tom qab phais tas.

• Seb puas muaj kev hloov hauv qee cov noob caj noob ces.

• Seb tus menyuam puas muaj NF1 lossis mob ntsws txhaws txhaws.

• Seb tus me nyuam muaj mob diencephalic syndrome (ib qho mob uas ua rau nws loj hlob qeeb).

• Seb tus me nyuam puas mob ntshav txhaws (cerebrospinal kua siab nyob hauv pob txha taub hau siab) thaum lub sij hawm kuaj mob.

• Txawm hais tias astrocytoma nyuam qhuav tau kuaj mob lossis tau rov muaj dua (rov qab los).

Txog kev rov qab zoo astrocytoma, kev kuaj pom thiab kho yog nyob ntawm ntau npaum li cas lub sijhawm dhau los ntawm lub sijhawm kev kho mob tiav thiab lub sijhawm astrocytoma rov muaj dua.

Theem Cov Menyuam yaus Astrocytomas

QHOV TSEEM CEEB

• Qeb cov qog siv los npaj kho mob cancer.

• Tsawg-qib astrocytomas

• High-qib astrocytomas

• Tus MRI tau ua tom qab kev phais mob.

Qeb cov qog siv los npaj kho mob cancer.

Cov theem yog txheej txheem siv los tshawb pom muaj ntau npaum li cas cancer yog thiab yog tias mob cancer kis tau. Nws yog ib qho tseem ceeb uas yuav tsum paub txog theem kom thiaj li npaj tau kev kho mob.

Tsis muaj ib qho qauv kab ke rau me nyuam astrocytoma. Txoj kev kho yog raws li cov hauv qab no:

• Txawm tias lub qog noj qes dua los yog qib siab.

• Seb puas yog qhov hlav tshiab raug kuaj lossis rov ua dua tshiab (tau rov qab los tom qab kev kho mob).

Qeb ntawm qog qhia txog tias cov qog nqaij hlav hauv lub cev saib txawv li cas hauv lub tshuab tsom thiab kom sai npaum li cas lub qog yuav loj tuaj thiab kis mus.

Cov qhab nia hauv qab no yog siv:

Tsawg-qib astrocytomas

Qeb astrocytomas qis-tau qeeb qeeb thiab tsis tshua muaj kis mus rau lwm qhov ntawm lub hlwb thiab tus txha caj qaum lossis lwm qhov ntawm lub cev. Muaj ntau ntau hom qes astrocytomas. Tsawg-qib astrocytomas tuaj yeem yog:

• Qog I hlav qog – pilocytic astrocytoma, qog cell subependymal, los yog angiocentric glioma.

• Qib II qog – diffuse astrocytoma, pleomorphic xanthoastrocytoma, lossis choroid glioma ntawm peb lub ventricle.

Cov menyuam yaus tus mob neurofibromatosis type 1 yuav muaj ntau dua ib cov qog ntshav qis hauv lub hlwb. Cov menyuam yaus uas mob hlab hlwb txha muaj qhov txhawm rau txhawm rau txhawm txhawm txhawm rau txhawm rau txhawm rau txha caj qaum.

High-qib astrocytomas

High-qib astrocytomas tau nrawm nrawm thiab feem ntau kis tau hauv hlwb thiab leeg nrob qaum. Muaj ntau ntau hom astrocytomas-qib siab. Qeb kawm siab astrocytomas tuaj yeem yog:

• Qog III Qog – anaplastic astrocytoma lossis anaplastic pleomorphic xanthoastrocytoma.

• Qib IV hlav hlav – glioblastoma lossis diffuse midline hlav.

Astrocytomas Menyuam yaus feem ntau tsis kis mus rau lwm qhov ntawm lub cev.

Tus MRI tau ua tom qab kev phais mob.

Ib qho MRI (sib nqus resonance duab) yog ua nyob rau thawj ob peb hnub tom qab kev phais. Qhov no yog txhawm rau nrhiav pom mob qog npaum li cas, yog tias muaj, tseem tshuav sijhawm tom qab phais thiab npaj kho ntxiv.

Sab Hauv Thaum Yau Raug Astrocytomas

Ib qho rov qab cov me nyuam astrocytoma yog astrocytoma uas tau rov muaj dua (rov qab los) tom qab nws tau kho. Tus kabmob yuav rov los nyob ntawm thaj chaw qub uas yog qhov mob qog lossis lwm qhov ntawm lub cev. High-qib astrocytomas feem ntau rov tshwm sim tsis pub dhau 3 xyoo nyob rau hauv qhov chaw mob qog nqaij hlav thawj zaug lossis lwm qhov chaw hauv CNS.

Txoj Kev Kho Mob Cov Tswv Yim

QHOV TSEEM CEEB

• Muaj ntau txoj kev kho rau cov neeg mob uas muaj hnub nyoog astrocytoma.

• Cov menyuam yaus nrog astrocytomas yuav tsum muaj lawv cov kev npaj kho mob los ntawm pab pawg saib xyuas kev noj qab haus huv uas yog cov kws tshaj lij hauv kev kho cov qog hlwb thaum yau.

• Cov qog ntawm lub hlwb thaum yau yuav ua rau cov cim lossis cov tsos mob uas pib ua ntej kuaj mob qog ntshav thiab tau txuas ntxiv rau lub hlis lossis xyoo.

• Kev kho rau astrocytomas thaum yau ua rau muaj kev phiv.

• Rau hom kev kho mob yog siv:

• Kev phais mob

• Kev Soj Ntsuam

• Kev siv hluav taws xob

• Kws khomob

• Kev siv tshuaj ntau ntxiv nrog cov qog hloov qog

• Cov hom phiaj kho

• Cov hom kev kho mob tshiab tau raug sim hauv qhov kev sim kho mob.

• Lwm txoj kev kho tshuaj

• Kev Txhaj Tshuaj Tiv Thaiv

• Yog kua muaj ntau ncig lub hlwb thiab leeg nrob qaum, yeej ua tau ib txoj kev tso kua mis tso ntshav tawm.

• Cov neeg mob yuav xav txog kev sim kho mob.

• Cov neeg mob tuaj yeem nkag mus kuaj mob ua ntej, sijhawm, lossis tom qab pib kho mob qog noj ntshav.

• Tej zaum yuav tau ua raws li kev ntsuam xyuas.

Muaj ntau txoj kev kho rau cov neeg mob uas muaj hnub nyoog astrocytoma.

Kev kho mob sib txawv muaj rau cov menyuam yaus nrog astrocytomas. Qee qhov kev kho mob yog tus qauv (cov kev kho mob tam sim no), thiab qee qhov raug sim hauv kev kuaj mob. Ib txoj kev kho mob hauv tsev kho mob yog txoj kev tshawb nrhiav uas pab txhawm rau txhim kho kev kho mob tam sim no lossis tau txais cov ntaub ntawv ntawm kev kho mob tshiab rau cov neeg mob cancer. Thaum kuaj pom tias cov kev kho tshiab zoo dua li kev kho mob, cov kev kho mob tshiab tuaj yeem dhau los ua cov qauv kev kho mob.

Vim tias mob qog noj ntshav rau menyuam yaus yog muaj tsawg, kev koom nrog kev sim tshuaj yuav tsum tau coj los xav. Qee qhov kev sim tshuaj sim tsuas yog qhib rau cov neeg mob uas tsis tau pib kho.

Cov menyuam yaus nrog astrocytomas yuav tsum muaj lawv cov kev npaj kho mob los ntawm pab pawg saib xyuas kev noj qab haus huv uas yog cov kws tshaj lij hauv kev kho cov qog hlwb thaum yau.

Kev kho yuav raug saib xyuas los ntawm tus kws kho menyuam yaus, kws kho mob tshwj xeeb hauv kev kho menyuam yaus mob qog noj ntshav. Tus kws kho menyuam yaus ua haujlwm nrog lwm tus kws saib xyuas kev noj qab haus huv uas yog tus kws tshaj lij hauv kev kho cov menyuam yaus mob hlwb thiab tus kws tshaj lij hauv qee thaj chaw tshuaj. Cov no yuav suav nrog cov kws tshwj xeeb hauv qab no:

• Kws kho mob hlwb.

• Kev Kuaj Mob Tom Qab neurourgeon.

• Neurologist.

• Tus Tshuaj Neuropathologist.

• Neuroradiologist.

• Cov kws tshaj lij fab kev peem tsheej.

• Kws phais hluav taws xob oncologist.

• Endocrinologist.

• Kws tshuaj sab laj.

Cov qog ntawm lub hlwb thaum yau yuav ua rau cov cim lossis cov tsos mob uas pib ua ntej kuaj mob qog ntshav thiab tau txuas ntxiv rau lub hlis lossis xyoo.

Cov cim lossis cov tsos mob tshwm sim los ntawm cov qog yuav pib ua ntej kev kuaj mob. Cov tsos mob lossis cov tsos mob no yuav txuas ntxiv mus txog ntau hli lossis xyoo. Nws yog ib qho tseem ceeb kom tham nrog koj tus menyuam tus kws kho mob txog cov cim lossis cov tsos mob tshwm sim los ntawm cov qog uas yuav txuas ntxiv tom qab kho tas.

Kev kho rau astrocytomas thaum yau ua rau muaj kev phiv.

Yog xav paub txog cov kev mob tshwm sim uas pib thaum kho mob cancer, mus saib peb Nplooj Ntawv Sab Npab.

Cov kev mob tshwm sim los ntawm kev kho mob cancer uas pib tom qab kho thiab txuas ntxiv rau lub hlis lossis xyoo yog hu ua kev mob lig. Kev lig dhau los ntawm kev kho mob cancer tej zaum yuav muaj cov hauv qab no:

• Lub cev muaj teeb meem.

• Hloov pauv hauv txoj kev xav, kev xav, kev xav, kev kawm, lossis kev nco.

• Kab mob qog zaum ob (hom qog nqaij hlav tshiab).

Qee qhov cuam tshuam tom qab tuaj yeem kho lossis tswj tau. Nws yog ib qho tseem ceeb nrog kws kho mob tham nrog koj tus menyuam tus kws kho mob hais txog cov kev kho mob cancer yuav muaj rau koj tus menyuam. (Saib cov ntsiab lus hais txog Cov Kev Kho Mob Npaws Sij Hawm Rau Kev Mob Hlwb Me Nyuam Me kom paub ntau ntxiv.)

Rau hom kev kho mob yog siv:

Kev phais mob

Kev phais mob yog siv rau kev kuaj mob thiab kho tus me nyuam astrocytoma, raws li tau tham hauv tshooj Cov Lus Qhia General ntawm daim ntawv no. Yog tias cov qog nqaij hlav cancer nyob tom qab phais tas, kho ntxiv yog nyob ntawm:

• Qhov twg cov kabmob kheesxaws tseem nyob.

• Cov qeb ntawm cov qog.

• Lub hnub nyoog ntawm tus menyuam.

Tom qab tus kws kho mob tshem tawm tag nrho cov qog ntshav uas tuaj yeem pom lub sijhawm phais mob, qee tus neeg mob yuav tau txais kev kho mob lossis tshuaj tua hluav taws xob tom qab phais mob los tua txhua cov kab mob qog nqaij hlav uas tseem tshuav. Kev kho mob tom qab qhov kev phais mob, txhawm rau txo qis kev mob qog noj ntshav yuav rov qab tuaj, hu ua kev kho mob rau tom qab.

Kev Soj Ntsuam

Kev soj ntsuam yog saib zoo rau tus neeg mob lub sijhawm yam tsis tau muab kev kho kom txog thaum tus mob lossis cov tsos mob tshwm lossis hloov pauv. Tej zaum yuav siv kev soj ntsuam:

• Yog tias tus neeg mob tsis muaj cov tsos mob, xws li cov neeg mob neurofibromatosis type1.

• Yog tias cov qog ntshav tau me me thiab pom thaum muaj lwm yam mob txawv los kuaj lossis kho.

• Tom qab cov qog tshem tawm los ntawm kev phais kom txog thaum pom tshwm sim lossis cov tsos mob tshwm sim lossis hloov.

Kev siv hluav taws xob

Kev xoo hluav taws xob yog kev kho mob cancer uas siv hluav taws xob xoo hluav taws xob loj lossis lwm yam hluav taws xob tua ntau los tua cov qog nqaij hlav cancer lossis ua kom lawv loj tuaj. Muaj ob txoj kev kho hluav taws xob:

• Kev siv hluav taws xob sab nraud siv lub tshuab sab nraud lub cev xa hluav taws xob mus rau cov kabmob. Qee txoj hauv kev los muab kev ntsuas hluav taws xob tuaj yeem pab ua kom hluav taws xob txhawm rau ua kom cov nqaij mos noj qab haus huv nyob ze. Cov hluav taws xob kev kho mob suav nrog cov hauv qab no:

• Kev Kho Hluav Taws Xob (Conformal radiation therapy): Kev Kho Hluav Taws Xob (Conformal radiation therapy) yog ib hom kev kho hluav taws xob sab nraud uas siv lub khoos phis tawm los ua lub ntsej muag 3 daim duab (3-D) ntawm cov qog thiab ua cov duab hluav taws xob rau cov qog kom haum cov qog.

• Kev siv hluav taws xob ntau (IMRT): IMRT yog ib hom kev siv hluav taws xob sab nraud 3 txoj kev kho (3-D) sab nraud uas siv khoos phis tawm los ua cov duab ntawm qhov loj thiab cov qauv ntawm cov qog. Nyias cov nqaj ntawm cov hluav taws xob ntawm ntau qhov sib zog (qhov sib zog) tau tswj cov qog los ntawm ntau cov ces kaum.

• Txoj kev kho hluav taws xob (Stereotactic radiation therapy): Kev kho suab hluav taws xob yog hom kev kho hluav taws xob sab nraud. Lub taub hau nruj ua ke txuas nrog rau cov pob txha taub hau kom lub taub hau tseem nyob thaum kho hluav taws xob. Lub tshuab siv hluav taws xob ncaj qha rau ntawm cov qog. Qhov hno tag nrho ntawm cov hluav taws xob tau muab faib ua ob peb qho tshuaj me me dhau ob peb hnub. Cov txheej txheem no tseem hu ua stereotactic sab nraud-nqaj hluav taws xob kev kho thiab kev kho stereotaxic hluav taws xob.

• Proton nqaj hluav taws xob kev kho mob: Proton-beam kev kho yog ib hom kev siv hluav taws xob ntau, kho hluav taws xob sab nraud. Lub tshuab hluav taws xob tua hluav taws xob tsom cov kwj pov tseg (me me, pom, qhov zoo tshaj tawm) ntawm cov qog nqaij hlav cancer tua lawv.

• Kev kho hluav taws xob sab hauv yog siv cov tshuaj pleev hluav taws xob kaw hauv cov koob, noob, xov hlau, lossis cov paws menyuam uas tso ncaj qha mus rau lossis ze ntawm cov qog nqaij hlav cancer.

Txoj hauv kev siv hluav taws xob kho yog nyob ntawm seb hom qog thiab qhov twg cov qog tsim nyob rau hauv lub hlwb lossis tus txha caj qaum. Kev kho hluav taws xob sab nraud yog siv los kho astrocytomas thaum yau.

Kev ntsuas hluav taws xob rau lub hlwb tuaj yeem cuam tshuam kev loj hlob thiab kev loj hlob, tshwj xeeb tshaj yog cov menyuam yaus. Rau cov menyuam yaus hnub nyoog qis dua 3 xyoos, kev siv tshuaj kho mob yuav raug muab rau kev hloov kho, ncua lossis txo qhov xav tau hluav taws xob kho.

Kws khomob

Kev siv tshuaj kho mob yog kev kho mob cancer uas siv cov tshuaj los txwv kev loj hlob ntawm cov qog nqaij hlav cancer, los ntawm kev tua cov qog lossis txwv tsis pub faib. Thaum cov tshuaj tua kab mob noj los ntawm qhov ncauj lossis txhaj rau hauv txoj hlab ntshav lossis leeg, cov tshuaj nkag mus rau cov ntshav thiab tuaj yeem mus txog rau cov qog nqaij hlav ntshav thoob plaws lub cev (kev kho mob tshuaj thev naus laus zis). Thaum cov kws kho mob tso tshuaj rau ncaj qha mus rau cov kua dej ua kua tshuaj, ib qho khoom hauv nrog cev, lossis lub cev ua kom lub cev muaj xws li lub plab, cov tshuaj feem ntau cuam tshuam rau cov qog nqaij hlav cancer hauv cov chaw ntawd (thaj av tshuaj kho mob). Kev siv tshuaj kho hluav taws xob sib xyaw yog siv ntau dua ib qho tshuaj anticancer.

Txoj hauv kev siv tshuaj kho mob yuav muab nyob ntawm seb hom qog thiab qhov twg cov qog ntshav tsim nyob rau hauv lub hlwb lossis tus txha caj qaum. Kev siv tshuaj tiv thaiv kab ke hauv nruab nrab yog siv rau hauv kev kho mob ntawm cov menyuam yaus nrog astrocytoma. Kev siv tshuaj siab ntau yuav siv tau rau hauv kev kho mob rau cov menyuam yaus uas nyuam qhuav muaj tus kab mob astrocytoma tshiab khiv.

Kev siv tshuaj ntau ntxiv nrog cov qog hloov qog

Kev txhaj tshuaj siab ntau yog muab rau tua cov qog nqaij hlav cancer. Cov kab mob noj qab haus huv, suav nrog cov qe tsim cov ntshav, kuj raug rhuav tshem los ntawm kev kho mob qog noj ntshav. Kev hloov ntawm qia yog kev kho mob los hloov cov qe tsim cov qe ntshav. Cov qia hlwb (cov qe ntshav tsis txaus) raug tshem tawm los ntawm cov ntshav lossis pob txha mob ntawm tus neeg mob lossis tus neeg pub ntshav thiab raug khov thiab khaws cia. Tom qab tus neeg mob ua tiav kev kho mob tshuaj, cov qia hlwb raug thaws thiab muab rov qab rau tus neeg mob los ntawm kev hla tshuaj. Cov qog ntshav qog ua kom loj hlob mus rau (thiab txum tim) lub cev cov ntshav.

Rau cov qib astrocytoma uas tau rov qab los tom qab kev kho mob, kev siv tshuaj siab ntxiv nrog lub qog hloov qog siv yog tias tsuas muaj qee cov qog ntshav xwb.

Cov hom phiaj kho

Cov hom phiaj kho yog ib hom kev kho mob uas siv tshuaj los yog lwm yam tshuaj los txheeb xyuas thiab tua cov qe ntshav tshwj xeeb tsis yog ua mob rau cov leeg zoo li qub.

Nws muaj ntau ntau hom kev kho kom haum:

• Monoclonal antibody therapy siv cov tshuaj tiv thaiv kab mob hauv lub chaw kuaj ntshav, los ntawm ib hom kab mob tiv thaiv kab mob hauv lub cev, kom tsis txhob mob qog noj ntshav. Cov tshuaj tiv thaiv no tuaj yeem txheeb xyuas cov tshuaj ntawm qog nqaij hlav cancer lossis cov khoom qub uas tuaj yeem pab ua kom cov cell mob qog noj ntshav. Cov tshuaj tiv thaiv txuas rau cov tshuaj thiab tua cov qog nqaij hlav cancer, thaiv lawv qhov kev loj hlob, lossis txwv tsis pub kis mus rau lwm qhov. Cov kab mob monoclonal yog muab los ntawm kev lis ntshav mus rau hauv cov leeg ntshav. Lawv yuav raug siv nyob ib leeg lossis nqa tshuaj, co toxins, lossis khoom siv hluav taws xob ncaj qha mus rau qog nqaij hlav cancer.

Vascular endothelial kev loj hlob yam (VEGF) inhibitor txoj kev kho yog ib hom monoclonal antibody therapy:

• VEGF inhibitor kev kho: Cov qog nqaij hlav cancer ua cov tshuaj hu ua VEGF, uas ua rau cov hlab ntshav tshiab tsim (angiogenesis) thiab pab ua rau mob qog noj ntshav. VEGF inhibitors thaiv VEGF thiab nres cov ntshav tshiab ntawm kev tsim. Qhov no tuaj yeem tua cov kabmob kheesxaws vim tias lawv xav tau cov hlab ntsha tshiab kom loj tuaj. Bevacizumab yog VEGF inhibitor thiab angiogenesis inhibitor raug siv los kho menyuam yaus astrocytoma.

• Protein kinase inhibitors ua hauj lwm nyob rau hauv kev sib txawv. Muaj ntau hom protein kinase inhibitors.

• mTOR inhibitors txwv cov hlwb tsis sib faib thiab tuaj yeem tiv thaiv kev loj hlob ntawm cov hlab ntsha tshiab uas cov qog xav tau loj hlob. Everolimus thiab sirolimus yog mTOR inhibitors siv los kho cov menyuam yaus subependymal giant cell astrocytomas. mTOR inhibitors tseem tabtom kawm kho kho qis astrocytoma uas tau rov muaj dua.

• BRAF inhibitors thaiv cov protein uas xav tau rau txoj kev loj hlob ntawm tes thiab tuaj yeem tua cov qog noj ntshav. BRAF gene yog pom nyob hauv ib qho hloov pauv (hloov pauv) hauv qee qhov gliomas thiab thaiv nws yuav pab ua rau cov kab mob qog noj ntshav tsis loj hlob. BRAF inhibitor dabrafenib tab tom kawm los kho kho qis astrocytoma uas tau rov muaj dua. Lwm qhov BRAF inhibitors, suav nrog vemurafenib thiab trametinib, tab tom kawm hauv menyuam yaus.

• MEK inhibitors thaiv cov protein uas xav tau rau txoj kev loj hlob ntawm tes thiab tuaj yeem tua cov qog noj ntshav. MEK inhibitors xws li selumetinib tab tom kawm los kho tus mob qis astrocytoma uas tau rov muaj dua.

• PARP inhibitors thaiv cov enzyme hu ua PARP uas tau koom nrog ntau lub zog ntawm tes. Kev thaiv cov tshuaj PARP tuaj yeem pab ua kom cov cell mob qog noj ntshav los ntawm kev kho lawv cov DNA uas puas lawm, ua rau lawv tuag. Veliparib yog PARP inhibitor uas tau kawm ua ke nrog kev kho hluav taws xob thiab kev siv tshuaj kho mob los kho cov kab mob mali tshiab tshiab uas tsis muaj kev hloov pauv (hloov) hauv BRAF gene.

Mus Saib Cov Tshuaj Pom Zoo rau Kev Mob Hlwb Hlwb rau cov lus qhia ntxiv.

Cov hom kev kho mob tshiab tau raug sim hauv qhov kev sim kho mob.

Tshooj lus kawg piav txog kev kho mob uas tau kawm hauv kev sim tshuaj. Nws yuav tsis hais txog txhua txoj kev kho tshiab tau kawm. Cov ntaub ntawv hais txog kev sim kho mob muaj nyob rau ntawm NCI lub vev xaib.

Lwm txoj kev kho tshuaj

Lenalidomide yog ib hom tshuaj tiv thaiv angiogenesis inhibitor. Nws tiv thaiv kev loj hlob ntawm cov hlab ntsha tshiab uas xav tau los ntawm cov qog ua kom loj hlob.

Kev Txhaj Tshuaj Tiv Thaiv

Kev Siv Tshuaj Tiv Thaiv yog ib txoj kev kho mob uas siv tus neeg mob lub cev tiv thaiv kab mob cancer. Cov tshuaj uas tsim los ntawm lub cev lossis tsim hauv chav siv tshuaj yog siv los txhawb, ncaj qha, lossis rov kho lub cev lub cev los tiv thaiv tus mob qog nqaij hlav. Hom kev kho mob cancer no tseem hu ua biotherapy lossis biologic therapy.

• Kev siv tshuaj tiv thaiv kab mob hauv lub cev: PD-1 yog protein nyob rau saum npoo ntawm T cell uas pab ua kom lub cev tiv thaiv kab mob hauv lub tshev. Thaum PD-1 txuas mus rau lwm cov protein hu ua PDL-1 ntawm tus kabmob kheesxaws, nws tso tseg T cell los tua cov qog nqaij hlav cancer. PD-1 inhibitors txuas rau PDL-1 thiab tso cai rau T cell tua cov qog nqaij hlav cancer. PD-1 inhibitors tau kawm los kho cov qib siab astrocytoma uas tau rov muaj dua.

Kev siv tshuaj tiv thaiv kab mob. Kuaj xyuas cov protein, xws li PD-L1 ntawm cov qog hlwb thiab PD-1 ntawm T hlwb, pab ua kom lub cev tsis muaj zog hauv tshuaj xyuas. Kev khi ntawm PD-L1 rau PD-1 ua rau T hlwb los ntawm kev tua cov qog ntshav hauv lub cev (sab laug vaj huam sib luag). Kev thaiv cov ntawv cog lus ntawm PD-L1 rau PD-1 nrog kev tiv thaiv kab mob hauv lub cev tiv thaiv kab mob (tiv thaiv PD-L1 lossis anti-PD-1) tso cai rau T cell tua cov qog nqaij hlav hlwb (muaj vaj huam sib luag).

Yog kua muaj ntau ncig lub hlwb thiab leeg nrob qaum, yeej ua tau ib txoj kev tso kua mis tso ntshav tawm.

Cerebrospinal kua sib txawv yog ib txoj kev siv los tso kua dej uas tau tsim los ncig lub hlwb thiab tus txha caj qaum. Ib qho shunt (ntev, nyias lub raj) tso rau hauv lub ventricle (dej puv qhov chaw) ntawm lub hlwb thiab xov hauv qab daim tawv nqaij mus rau lwm qhov ntawm lub cev, feem ntau yog lub plab mog. Lub shunt nqa dej ntxiv kom deb ntawm lub hlwb thiaj li yuav nqus tau lwm qhov hauv lub cev.

Cerebrospinal kua dej (CSF) kev ua si. Ntxiv CSF raug tshem tawm los ntawm txoj hlab ntsha hauv lub hlwb los ntawm kev sib dhos (lub raj) thiab tawm mus rau hauv plab. Lub valve tswj cov dej ntws ntawm CSF.

Cov neeg mob yuav xav txog kev sim kho mob.

Txog qee tus neeg mob, koom nrog kev sim kho mob yuav yog txoj kev xaiv zoo tshaj plaws. Cov chaw kuaj mob yog ib feem ntawm cov txheej txheem tshawb mob qog noj ntshav. Cov chaw kho mob tau sim ua kom pom tias kev kho mob qog noj ntshav tshiab muaj kev nyab xeeb thiab zoo dua lossis zoo dua cov qauv tshuaj.

Ntau yam ntawm cov qauv kev kho mob qog noj ntshav niaj hnub no yog los ntawm cov kev tshawb fawb kab mob thaum ntxov. Cov neeg mob uas koom nrog kev sim kho mob tuaj yeem tau txais cov qauv kev kho mob lossis ua thawj zaug tau txais kev kho mob tshiab.

Cov neeg mob uas koom nrog kev sim kho mob kuj pab txhim kho txoj kev kho mob qog nqaij hlav yav tom ntej. Txawm hais tias kev sim tshuaj sim tsis ua rau muaj kev kho mob tshiab, lawv feem ntau teb cov lus nug tseem ceeb thiab pab txav kev tshawb fawb tom ntej.

Cov neeg mob tuaj yeem nkag mus kuaj mob ua ntej, sijhawm, lossis tom qab pib kho mob qog noj ntshav.

Qee qhov kev sim tshuaj tsuas yog suav nrog cov neeg mob uas tseem tsis tau txais kev kho mob. Lwm txoj kev sim sim cov kev kho mob rau cov neeg mob uas mob qog noj qab tsis tau zoo dua. Kuj tseem muaj cov kev sim tshuaj kuaj mob uas sim txoj kev tshiab los txwv qog noj ntshav kom tsis txhob mob ntxiv (rov qab los) lossis txo kev phiv los ntawm kev kho mob qog noj.

Cov chaw kuaj mob tau tshwm sim nyob rau ntau lub tebchaws. Cov ntaub ntawv hais txog kev sim kho mob uas tau txhawb nqa los ntawm NCI tuaj yeem nrhiav pom ntawm NCI cov chaw kuaj mob tshawb nrhiav lub vev xaib. Cov chaw kuaj mob txhawb nqa los ntawm lwm cov koomhaum tuaj yeem nrhiav pom ntawm ClinicalTrials.gov lub vev xaib.

Tej zaum yuav tau ua raws li kev ntsuam xyuas.

Qee qhov kev ntsuas mob uas tau ntsuas los kuaj mob qog noj ntshav lossis kom pom tias theem mob cancer yuav rov qab ua dua. (Saib Tshooj Lus Qhia dav dav rau cov npe ntawm cov ntawv kuaj.) Qee qhov kev sim yuav rov ua dua kom pom tias qhov kev kho mob ua haujlwm tau zoo npaum li cas. Cov kev txiav txim siab hais txog seb puas yuav txuas ntxiv, hloov, lossis tsum tsis mus kho yuav ua raws cov txiaj ntsig ntawm cov kev ntsuas no.

MRIs ib txwm yuav ua txuas ntxiv tom qab kev kho mob tas. Cov txiaj ntsig ntawm MRI tuaj yeem qhia tau yog tias koj tus menyuam tus mob tau hloov lossis yog astrocytoma tau rov muaj dua (rov qab los). Yog tias cov txiaj ntsig ntawm MRI qhia pom tias muaj ntau qhov hauv lub hlwb, kuaj cov nqaij mus kuaj seb puas muaj los ntawm cov qog hlwb tuag lossis yog tias cov qog nqaij hlav cancer nce tshiab.

Cov Kev Xaiv Kho rau Menyuam Yaus Astrocytomas

Hauv Tshooj Lus no

• Cov Ntseeg Tshiab Raug Kuaj Me Nyuam Qis-Qis Astrocytomas

• Rov Ntshaw Me Nyuam Yaus Qib-Astrocytomas

• Tshiab Tsim Tshuaj Kiag Me Nyuam Loj Qib Siab-Astrocytomas

• Rov Ntshaw Me Nyuam Me Qib High-Qib Astrocytomas

Yog xav paub txog cov kev kho mob uas teev rau hauv qab no, saib hauv Cov Lus Qhia Kev Xaiv Kev Xaiv.

Cov Ntseeg Tshiab Raug Kuaj Me Nyuam Qis-Qis Astrocytomas

Thaum kuaj cov qog ua ntej, kev kho mob rau cov menyuam yaus qib qis astrocytoma nyob ntawm seb qhov twg mob qog, thiab feem ntau yog phais mob. MRI ua tiav tom qab kev phais mob seb puas tshuav qog.

Yog tias cov qog ntshav tau raug tshem tawm tag nrho los ntawm kev phais mob, tsis tuaj yeem siv tshuaj kho ntxiv thiab tus menyuam yuav tau saib zoo kom pom seb puas muaj cov cim lossis tsos mob tshwm lossis hloov. Qhov no hu ua kev soj ntsuam.

Yog tias muaj qog tshuav tom qab phais, kev kho mob tuaj yeem suav nrog cov hauv qab no:

• Kev Soj Ntsuam.

• Kev phais ob mus tshem tawm cov qog.

• Kev kho hluav taws xob, uas tej zaum yuav suav nrog kev kho hluav taws xob, kev kho hluav taws xob ntau, kev siv tshuaj tua hluav taws xob, kev kho mob hluav taws xob, lossis kev kho hluav taws xob, thaum lub qog pib loj dua.

• Kev sib xyaw ua ke nrog tshuaj kho mob nrog lossis tsis siv tshuaj tua hluav taws xob.

• Kev sim kho mob rau cov hom phiaj kho nrog kev sib xyaw ntawm BRAF inhibitors (dabrafenib thiab trametinib) hauv cov neeg mob uas muaj kev hloov pauv hauv BRAF lub cev.

Muaj qee kis, kev tshuaj xyuas yog siv rau cov menyuam yaus uas muaj lub qhov muag pom kev glioma. Hauv lwm qhov xwm txheej, kev kho yuav suav nrog kev phais kom tshem tawm cov qog, kho hluav taws xob, lossis kev siv tshuaj kho mob. Lub hom phiaj ntawm txoj kev kho yog kom txuag tau lub zeem muag ntau li ntau tau. Qhov tshwm sim ntawm cov qog ntawm cov menyuam yaus lub zeem muag yuav ua raws nraim thaum kho.

Cov menyuam yaus neurofibromatosis type 1 (NF1) yuav tsis xav tau kev kho mob tshwj tsis yog lub qog loj tuaj lossis cov pa lossis cov tsos mob, xws li teeb meem tsis pom kev, tshwm sim. Thaum cov qog loj tuaj lossis cov paib lossis cov tsos mob tshwm sim, kev kho mob yuav suav nrog kev phais kom tshem tawm cov qog, kho hluav taws xob, thiab / lossis kev siv tshuaj kho mob.

Cov menyuam yaus uas mob hnoos qeev txha caj qaum yuav ua mob qog ua hlav nyob rau hauv lub hlwb hu ua subependymal giant cell astrocytomas (SEGAs). Kev siv hom phiaj nrog everolimus lossis sirolimus tuaj yeem siv los ntawm kev phais mob, kom qog cov qog.

Siv peb qhov kev tshawb nrhiav kab mob hauv tsev kho mob kom pom qhov NCI-txhawb nqa kev mob qog nqaij hlav uas pom zoo rau cov neeg mob. Koj tuaj yeem tshawb xyuas cov kev sim raws li hom mob cancer, hnub nyoog ntawm tus neeg mob, thiab qhov chaw uas sim kev sim. Cov ncauj lus dav dav txog kev sim kho mob kuj muaj.

Rov Ntshaw Me Nyuam Yaus Qib-Astrocytomas

Thaum qis astrocytoma rov qab los tom qab kho, feem ntau nws rov qab los qhov chaw uas cov qog ua ntej. Ua ntej yuav muab tshuaj kho mob qog nqaij hlav ntau, ntsuam xyuas qog, kuaj ib ce, los yog phais mob txhawm rau kuaj seb puas muaj mob qog nqaij hlav cancer thiab muaj ntau npaum li cas.

Kev kho kab mob astrocytoma hauv tsev me nyuam yaus pheej rov qab muaj xws li hauv qab no:

• Qhov kev phais thib ob kom tshem tawm cov qog, yog tias kev phais mob yog tib txoj kev kho mob thaum muab cov qog ntshav tau kuaj pom.

• Kev siv hluav taws xob mus rau qog tsuas yog, yog tias siv hluav taws xob tsis siv thaum tus hlav tau kuaj pom. Tej zaum yuav muab hluav taws xob rau kev sib txig sib luag.

• Kev siv tshuaj kho mob, yog tias cov qog rov mob dua qhov twg nws tsis tuaj yeem raug tshem tawm los ntawm kev phais mob lossis tus neeg mob tau kho mob hluav taws xob thaum cov qog ntshav tau kuaj pom thawj zaug.

• Cov hom phiaj kho nrog lub monoclonal antibody (bevacizumab) nrog lossis tsis muaj tshuaj kho.

• Kev kuaj mob hauv tsev kho mob uas kuaj pom ib qho piv txwv ntawm tus neeg mob qog mob rau qee yam hloov pauv gene. Hom kev hloov kho hom phiaj uas yuav muab rau tus neeg mob nyob ntawm hom kev hloov pauv ntawm gene.

• Kev sim tshuaj mob ntawm cov hom phiaj kho nrog BRAF inhibitor (dabrafenib), mTOR inhibitor (everolimus), lossis MEK inhibitor (selumetinib).

Siv peb qhov kev tshawb nrhiav kab mob hauv tsev kho mob kom pom qhov NCI-txhawb nqa kev mob qog nqaij hlav uas pom zoo rau cov neeg mob. Koj tuaj yeem tshawb xyuas cov kev sim raws li hom mob cancer, hnub nyoog ntawm tus neeg mob, thiab qhov chaw uas sim kev sim. Cov ncauj lus dav dav txog kev sim kho mob kuj muaj.

Tshiab Tsim Tshuaj Kiag Me Nyuam Loj Qib Siab-Astrocytomas

Kev kho cov me nyuam qib siab astrocytoma tuaj yeem suav nrog cov hauv qab no:

• Kev phais tawm mus tshem tawm cov qog, ua raws li kev siv tshuaj kho mob thiab / lossis kev siv hluav taws xob kho.

• Kev kuaj mob hauv kev kho tus mob tshiab.

• Kev sim tshuaj mob ntawm cov hom phiaj kho nrog PARP inhibitor (veliparib) ua ke nrog kev kho hluav taws xob thiab kev siv tshuaj kho mob los kho cov kab mob tshiab uas pom tias muaj cov kab mob glioma uas tsis muaj kev hloov pauv (hloov pauv) hauv BRAF gene.

Siv peb qhov kev tshawb nrhiav kab mob hauv tsev kho mob kom pom qhov NCI-txhawb nqa kev mob qog nqaij hlav uas pom zoo rau cov neeg mob. Koj tuaj yeem tshawb xyuas cov kev sim raws li hom mob cancer, hnub nyoog ntawm tus neeg mob, thiab qhov chaw uas sim kev sim. Cov ncauj lus dav dav txog kev sim kho mob kuj muaj.

Rov Ntshaw Me Nyuam Me Qib High-Qib Astrocytomas

Thaum high-qib astrocytoma rov tshwm sim tom qab kev kho mob, nws feem ntau rov qab los qhov twg cov qog ua ntej tsim. Ua ntej yuav muab tshuaj kho mob qog nqaij hlav ntau, ntsuam xyuas qog, kuaj ib ce, los yog phais mob txhawm rau kuaj seb puas muaj mob qog nqaij hlav cancer thiab muaj ntau npaum li cas.

Kev kho tus mob astrocytoma thaum yau dua tuaj yeem suav nrog cov hauv qab no:

• Kev phais kom tshem tawm cov qog.

• Kev siv tshuaj ntau ntxiv nrog cov qog hloov qog.

• Cov hom phiaj kho nrog BRAF inhibitor (vemurafenib lossis dabrafenib).

• Kev sim tshuaj rau cov tshuaj tiv thaiv kab mob nrog rau cov tshuaj tiv thaiv kab mob hauv lub cev.

• Kev kuaj mob hauv tsev kho mob uas kuaj pom ib qho piv txwv ntawm tus neeg mob qog mob rau qee yam hloov pauv gene. Hom kev hloov kho hom phiaj uas yuav muab rau tus neeg mob nyob ntawm hom kev hloov pauv ntawm gene.

• Kev sim kho mob rau cov hom phiaj kho nrog kev sib xyaw ntawm BRAF inhibitors (dabrafenib thiab trametinib) hauv cov neeg mob uas muaj kev hloov pauv hauv BRAF lub cev.

Siv peb qhov kev tshawb nrhiav kab mob hauv tsev kho mob kom pom qhov NCI-txhawb nqa kev mob qog nqaij hlav uas pom zoo rau cov neeg mob. Koj tuaj yeem tshawb xyuas cov kev sim raws li hom mob cancer, hnub nyoog ntawm tus neeg mob, thiab qhov chaw uas sim kev sim. Cov ncauj lus dav dav txog kev sim kho mob kuj muaj.

Yog Xav Paub Ntxiv Hais Txog Cov Menyuam Yaus Astrocytomas

Yog xav paub ntxiv txog astrocytomas thaum yau, saib cov hauv qab no:

• Hom Kab Mob Kuaj Mob Cancer

• Kev Kuaj Mob Hauv Hlwb Hlwb Menyuam (PBTC) Kev Tawm Tsam Dab Tsi

Yog xav paub ntau ntxiv txog kev mob qog noj ntshav thaum tseem yau thiab lwm yam kev qhia txog mob qog noj ntshav, saib cov hauv qab no:

• Txog Mob Cancer

• Kev Menyuam Kab Menyuam Kiag

• CureSearch rau Cov Menyuam Txoj Kev Mob Cancer

• Qhov Zoo Los Ntawm Txoj Kev Kho Mob Kheev Me Menyuam Thaum Ntxov

• Cov Hluas thiab Cov Hluas Hluas Muaj Mob Cancer

• Cov Menyuam Muaj Mob Cancer: Cov Lus Qhia rau Niam Txiv

• Mob Cancer rau Cov Menyuam thiab Cov Hluas

• Qib

• Kev Muaj Mob Cancer

• Cov Lus Nug Yuav Nug Koj Tus Kws Kho Mob txog Kab Mob Cancer

• Rau Cov Muaj Txoj Sia Nyob thiab Cov Saib Xyuas