About-cancer/treatment/clinical-trials/thymoma-thymic-carcinoma
Cov chaw kuaj mob los kho Thymoma thiab Thymic Carcinoma
Kev Txom Nyem 1-12 ntawm 12
Carboplatin thiab Paclitaxel nrog lossis tsis muaj Ramucirumab hauv Kev Kho Mob Rau Cov Neeg Mob Nrog Kev Tshaj Lij Tshaj Plaws Hauv Ib Cheeb Tsam, Kev Rov Ua Dua, lossis Metastatic Thymic Cancer uas tsis tuaj yeem raug tshem tawm los ntawm Kev Kho Mob
Qhov kev sim qib II hauv kev sim no zoo li cas carboplatin thiab paclitaxel nrog lossis tsis muaj ramucirumab ua haujlwm hauv kev kho cov neeg mob qog nqaij hlav ntshav uas tau kis mus rau cov nqaij lossis cov qog ntshav (ze hauv zos), tau rov qab los (ib qho ntxiv), tau kis mus rau lwm qhov chaw hauv lub cev (metastatic) lossis tsis tuaj yeem raug tshem tawm los ntawm kev phais mob. Cov tshuaj siv hauv kev siv tshuaj kho mob, xws li carboplatin thiab paclitaxel, ua haujlwm nyob rau ntau txoj hauv kev los tiv thaiv kev loj hlob ntawm cov qog nqaij hlav, los ntawm tua cov qog hlwb, los ntawm kev txwv kom tsis txhob faib tawm, lossis txwv tsis pub kis mus rau. Cov tshuaj tiv thaiv monoclonal, xws li ramucirumab, tuaj yeem cuam tshuam kev muaj peev xwm ntawm cov qog ua kom loj hlob thiab kis tau. Tseem tsis tau paub yog tias muab cov carboplatin thiab paclitaxel nrog lossis tsis muaj ramucirumab yuav ua haujlwm zoo dua rau kev kho cov neeg mob qog nqaij hlav cancer.
Qhov chaw: 254 qhov chaw
Kev Tshawb Fawb Txog XmAb®20717 Hauv Cov Ntsiab Lus Nrog Xaiv Qiv Cov Pob Qij Qib Dua
Qhov no yog Ntu 1, ntau koob tshuaj, nce ntxiv koob tshuaj tiv thaiv kev kawm tshawb xyuas los txhais lub MTD / RD thiab kev tswj hwm ntawm XmAb20717, kom piav qhia txog kev nyab xeeb thiab tiv taus, soj ntsuam PK thiab tshuaj tiv thaiv kab mob, thiab ntsuas ua ntej ntsuas cov qog ua haujlwm ntawm XmAb20717 hauv cov ncauj lus nrog xaiv paub ntau yam khoom hlav.
Qhov chaw: 15 thaj chaw
Nivolumab thiab Vorolanib hauv Kev Kho Mob rau Cov Neeg Mob Uas Tsis Muaj Cov Nqaij Hlawv Mob Tsis Muaj Qhav Rau Mob thiab Tsis Ciav Thoracic Tumors
Theem I / II kev sim no kawm txog cov kev mob tshwm sim thiab qhov zoo tshaj plaws ntawm vorolanib thaum muab nrog nivolumab hauv kev kho mob rau cov neeg mob uas tsis mob qog nqaij hlav hauv hlwb tsawg thiab thoracic mob uas tsis teb rau kev kho mob (refractory). Kev txhaj tshuaj tiv thaiv kab mob nrog monoclonal tiv thaiv kab mob, xws li nivolumab, tuaj yeem pab lub cev tiv thaiv kab mob hauv lub cev tua cov kabmob, thiab yuav cuam tshuam lub peev xwm ntawm cov qog ntshav kom loj hlob thiab kis tau. Vorolanib yuav tso tseg txoj kev loj hlob ntawm cov qog ntshav los ntawm kev thaiv qee cov enzymes uas xav tau rau kev loj hlob ntawm tes. Kev muab nivolumab thiab vorolanib tuaj yeem ua haujlwm zoo dua rau kev kho mob rau cov neeg mob uas tsis yog mob ntsws me me hauv lub ntsws thiab cov qog thoracic.
Qhov chaw: 7 thaj chaw
Txoj kev tshawb ntawm SO-C101 thiab SO-C101 hauv Kev Sib xyaw Nrog Pembro hauv Cov Neeg Mob Loj Dua nrog Kev Tshaj Tawm / Metastatic Cov Pob Qij Qog
Ntau qhov chaw qhib-daim ntawv lo rau theem 1 / 1b kawm txog kev soj ntsuam kev nyab xeeb thiab kev ua tau zoo ntawm SO-C101 raws li kev kho mob hlwb thiab kev sib xyaw nrog pembrolizumab hauv cov neeg mob uas tau xaiv cov qib siab / metastatic cov qog nqaij hlav.
Qhov chaw: 2 thaj chaw
Kev Tshawb Xyuas sai thiab Kev Ntsuam Xyuas Cov Lus Teb ntawm Cov Txheej Txheem Tiv Thaiv Neoplastic hauv Pob Qog Tsis Txhaum (RARE CANCER) Kev Sim: RARE 1 Nilotinib thiab Paclitaxel
Keeb kwm yav dhau los: Cov neeg muaj mob qog nqaij hlav feem ntau muaj kev xaiv kho tsawg. Lub biology ntawm cov qog nqaij hlav tsis tshua muaj kev nkag siab zoo. Cov kws tshawb nrhiav xav nrhiav txoj kev kho zoo dua rau cov qog nqaij hlav no. Lawv xav kuaj 2 cov tshuaj uas, noj ib qho, tau pab cov neeg uas tsis mob qog nqaij hlav tsis tshua muaj mob. Lawv xav pom tias cov tshuaj ua ke no tuaj yeem ua rau mob qog nqaij hlav tsawg lossis tso tseg tsis txhob loj hlob. Lub Hom Phiaj: Xav paub yog nilotinib thiab paclitaxel yuav muaj txiaj ntsig zoo rau cov neeg muaj mob qog nqaij hlav tsawg. Kev Muaj Cai Tau Txais: Cov neeg muaj hnub nyoog 18 xyoo thiab laus dua uas muaj mob tsawg, mob cancer uas tau nce siab tom qab tau txais kev kho mob tus qauv, lossis qhov uas tsis muaj kev kho kom zoo. Tsim: Cov neeg koom yuav raug tshuaj ntsuam xyuas keeb kwm kev mob thiab kuaj lub cev. Lawv yuav muaj kev kuaj ntshav thiab kuaj zis. Lawv yuav muaj kev kuaj cev xeeb tub yog tias xav tau. Lawv yuav muaj cov electrocardiogram los kuaj xyuas lawv lub plawv. Lawv yuav muaj duab ntxaij mus ntsuas lawv cov qog. Cov neeg koom yuav rov ua cov ntawv ntsuam xyuas thaum qhov kev kawm. Cov neeg tuaj koom yuav tau txais nilotinib thiab paclitaxel. Cov tshuaj tau muab rau hauv 28-hnub mus ncig. Nilotinib yog tshuaj ntsiav uas noj qhov ncauj ob zaug ib hnub. Paclitaxel yuav muab rau cov leeg nruab nrog kab lossis nruab nrab kab ib zaug ib lub lim tiam rau thawj 3 lub lim tiam ntawm txhua lub voj voog. Cov neeg koom yuav khaws cov ntawv sau cia tshuaj. Lawv yuav taug qab thaum lawv noj tshuaj kawm thiab kev phiv uas lawv muaj. Cov neeg koom yuav tuaj yeem kuaj pob qog noj tawm los tau. Cov neeg tuaj koom tuaj yeem koom nrog txoj kev tshawb no kom txog thaum lawv cov kab mob phem dua lossis lawv muaj kev phiv tshuaj tsis zoo. Cov neeg tuaj koom yuav tau hu xov tooj rov qab txog 30 hnub tom qab noj cov tshuaj kawg ntawm cov tshuaj kawm. Cov neeg tuaj koom yuav tau txais nilotinib thiab paclitaxel. Cov tshuaj tau muab rau hauv 28-hnub mus ncig. Nilotinib yog tshuaj ntsiav uas noj qhov ncauj ob zaug ib hnub. Paclitaxel yuav muab rau cov leeg nruab nrog kab lossis nruab nrab kab ib zaug ib lub lim tiam rau thawj 3 lub lim tiam ntawm txhua lub voj voog. Cov neeg koom yuav khaws cov ntawv sau cia tshuaj. Lawv yuav taug qab thaum lawv noj tshuaj kawm thiab kev phiv uas lawv muaj. Cov neeg koom yuav tuaj yeem kuaj pob qog noj tawm los tau. Cov neeg tuaj koom tuaj yeem koom nrog txoj kev tshawb no kom txog thaum lawv cov kab mob phem dua lossis lawv muaj kev phiv tshuaj tsis zoo. Cov neeg tuaj koom yuav tau hu xov tooj rov qab txog 30 hnub tom qab noj cov tshuaj kawg ntawm cov tshuaj kawm. Cov neeg tuaj koom yuav tau txais nilotinib thiab paclitaxel. Cov tshuaj tau muab rau hauv 28-hnub mus ncig. Nilotinib yog tshuaj ntsiav uas noj qhov ncauj ob zaug ib hnub. Paclitaxel yuav muab rau cov leeg nruab nrog kab lossis nruab nrab kab ib zaug ib lub lim tiam rau thawj 3 lub lim tiam ntawm txhua lub voj voog. Cov neeg koom yuav khaws cov ntawv sau cia tshuaj. Lawv yuav taug qab thaum lawv noj tshuaj kawm thiab kev phiv uas lawv muaj. Cov neeg koom yuav tuaj yeem kuaj pob qog noj tawm los tau. Cov neeg tuaj koom tuaj yeem koom nrog txoj kev tshawb no kom txog thaum lawv cov kab mob phem dua lossis lawv muaj kev phiv tshuaj tsis zoo. Cov neeg tuaj koom yuav tau hu xov tooj rov qab txog 30 hnub tom qab noj cov tshuaj kawg ntawm cov tshuaj kawm. Paclitaxel yuav muab rau cov leeg nruab nrog kab lossis nruab nrab kab ib zaug ib lub lim tiam rau thawj 3 lub lim tiam ntawm txhua lub voj voog. Cov neeg koom yuav khaws cov ntawv sau cia tshuaj. Lawv yuav taug qab thaum lawv noj tshuaj kawm thiab kev phiv uas lawv muaj. Cov neeg koom yuav tuaj yeem kuaj pob qog noj tawm los tau. Cov neeg tuaj koom tuaj yeem koom nrog txoj kev tshawb no kom txog thaum lawv cov kab mob phem dua lossis lawv muaj kev phiv tshuaj tsis zoo. Cov neeg tuaj koom yuav tau hu xov tooj rov qab txog 30 hnub tom qab noj cov tshuaj kawg ntawm cov tshuaj kawm. Paclitaxel yuav muab rau cov leeg nruab nrog kab lossis nruab nrab kab ib zaug ib lub lim tiam rau thawj 3 lub lim tiam ntawm txhua lub voj voog. Cov neeg koom yuav khaws cov ntawv sau cia tshuaj. Lawv yuav taug qab thaum lawv noj tshuaj kawm thiab kev phiv uas lawv muaj. Cov neeg koom yuav tuaj yeem kuaj pob qog noj tawm los tau. Cov neeg tuaj koom tuaj yeem koom nrog txoj kev tshawb no kom txog thaum lawv cov kab mob phem dua lossis lawv muaj kev phiv tshuaj tsis zoo. Cov neeg tuaj koom yuav tau hu xov tooj rov qab txog 30 hnub tom qab noj cov tshuaj kawg ntawm cov tshuaj kawm.
Qhov Chaw: Cov Tsev Kawm Ntawv Hauv Tebchaws ntawm Chaw Kuaj Mob Noj Qab Haus Huv, Bethesda, Maryland
Pembrolizumab thiab Sunitinib Malate hauv Kev Kho Cov Neeg Koom nrog Refractory Metastatic lossis Kev Tiv Thaiv Tsis Muaj Nqaij Hlawv
Kev sim qib II no paub txog pembrolizumab thiab sunitinib malate ua haujlwm li cas hauv kev kho cov neeg mob qog nqaij hlav cancer uas tau kis mus rau lwm qhov chaw hauv lub cev lossis tsis tuaj yeem raug tshem tawm los ntawm kev phais mob thiab tsis teb rau kev kho mob. Cov tshuaj tiv thaiv monoclonal, xws li pembrolizumab, tuaj yeem cuam tshuam kev muaj peev xwm ntawm cov qog ntshav hlav kom loj hlob thiab sib kis tau. Sunitinib malate tuaj yeem nres kev loj hlob ntawm cov qog ntshav los ntawm kev thaiv qee cov enzymes xav tau rau kev loj hlob ntawm tes. Muab pembrolizumab thiab sunitinib malate tuaj yeem ua haujlwm zoo dua los kho tus mob qog nqaij hlav cancer.
Qhov Chaw: Ohio Lub Tsev Kawm Ntawv Qib Siab Lub Chaw Kuaj Mob Cancer, Columbus, Ohio
Pembrolizumab Hauv Kev Kho Cov Neeg Koom nrog kev tsis tuaj yeem tiv thaiv kab mob qog lossis Thymic Cancer
Qeb no Kuv sim kawm txog ob sab thiab qhov zoo tshaj plaws ntawm pembrolizumab hauv kev kho cov neeg mob qog nqaij hlav cancer lossis thymic mob uas tsis tuaj yeem raug tshem tawm los ntawm kev phais mob. Kev txhaj tshuaj tiv thaiv kab mob nrog monoclonal tiv thaiv kab mob, xws li pembrolizumab, tuaj yeem pab lub cev tiv thaiv kab mob hauv lub cev tua cov kabmob, thiab yuav cuam tshuam lub peev xwm ntawm cov qog ua kom loj hlob thiab kis tau.
Qhov Chaw: MD Anderson Cancer Center, Houston, Texas
Selinexor hauv Kev Kho Cov Neeg Koom nrog Kev Qog Loj Thymic Epithelial Tumor
Kev sim qib II no tshawb nrhiav seb selinexor ua haujlwm zoo li cas hauv kev kho cov neeg koom nrog cov qog ua kom mob qog nqaij hlav mus rau lwm qhov chaw hauv lub cev. Selinexor tuaj yeem nres txoj kev loj hlob ntawm qog cov qog los ntawm kev thaiv qee cov protein uas xav tau rau kev loj hlob ntawm tes.
Qhov chaw: 2 thaj chaw
Bintrafusp Alfa (M7824) hauv Cov Teeb Meem nrog Thymoma thiab Thymic Carcinoma
Cov Neeg Tom Qab: Thymoma thiab thymic carcinoma yog cov kab mob ntawm thymus. Platinum-based chemotherapy yog txheej txheem kho rau cov kabmob no. Tab sis feem ntau, tus mob rov qab los tom qab kho tas. Cov kws tshawb nrhiav xav pom tias yam tshuaj tshiab muaj peev xwm pab tau. Lub Hom Phiaj: Los saib seb puas yog bintrafusp alfa (M7824) yog kev kho mob zoo rau thymoma thiab thymic carcinoma. Kev Tsim Nyog: Cov tib neeg hnub nyoog 18 thiab laus dua uas muaj mob thymoma lossis mob qog thiab lawv cov mob rov qab los yog ua tiav tom qab kho mob nrog tsawg kawg ib platinum-muaj cov tshuaj kho mob, lossis lawv tsis kam lees txoj kev kho qauv tsim: Cov neeg koom yuav raug kuaj raws li nyias muaj nyias kev cai. Lawv li keeb kwm kev kho mob, tshuaj thiab kev kho mob yuav raug tshuaj xyuas. Lawv yuav muaj lub qog nqaij hlav tawm yog tias lawv tsis muaj cov qauv. Cov neeg koom yuav tau txais cov tshuaj kawm ib zaug hauv txhua 2 asthiv raws li txoj kev tso ntshav hla dej. Rau qhov no, ib lub raj yas me me tau tso rau hauv txoj hlua caj npab. Thaum kawm, cov neeg koom yuav muaj cov hauv qab no: Tshuaj ntsuam lub cev Kev soj ntsuam Lub cev nqaij daim tawv thiab lawv lub peev xwm los ua lawv cov kev ua ub no Ntshav thiab zis Ntsig ntsuas mob rau cov leeg (siv MRI) Kev Ntsuas Cov Ntsuas (siv MRI lossis CT) Kev kuaj lub plawv thiab lub ntsws Kev kuaj ntsuas cov thyroid caj pas. Cov neeg tuaj koom tej zaum yuav mob qog nqaij hlav. Qee qhov ntawm lawv cov ntshav thiab kuaj ntshav coj mus kuaj yuav raug siv rau kev sim cov gene. Cov neeg tuaj koom yuav siv cov tshuaj tshawb no kom txog thaum lawv tus mob hnyav zuj zus lossis lawv tsis tuaj yeem thev taus kev kho mob. Cov neeg tuaj koom yuav muaj rov qab mus ntsib 2 thiab 6 lub lis piam tom qab nres kev kho mob. Tom qab ntawv lawv yuav muaj sijhawm mus ntsib sijhawm ntev txhua 3 lub hlis. Cov no suav nrog kev thaij duab tsis zoo. Kev mus ntsib tau hauv xov tooj, nrog rau scans (yog tias xav tau) ua rau ntawm lawv tus kws kho mob lub chaw haujlwm. Qhov chaw nyob:
Abexinostat thiab Pembrolizumab hauv Kev Kho Mob Rau Cov Neeg Mob nrog MSI-Qib Loj hauv zos lossis Kev Ntsuas Zoo Tshaj Plaws
Qeb no Kuv sim kawm txog qhov zoo tshaj plaws thiab qhov tshwm sim ntawm abexinostat thiab nws zoo npaum li cas ua haujlwm nrog muab ua ke nrog pembrolizumab hauv kev kho cov neeg mob nrog microsatellite instability (MSI) cov qog ua haujlwm uas tau kis mus rau cov nqaij lossis cov qog ntshav (ze hauv zos) lossis lwm qhov chaw hauv lub cev (metastatic). Abexinostat yuav tso tseg txoj kev loj hlob ntawm cov qog ntshav los ntawm kev thaiv qee cov enzymes uas xav tau rau kev loj hlob ntawm tes. Kev txhaj tshuaj tiv thaiv kab mob nrog monoclonal tiv thaiv kab mob, xws li pembrolizumab, tuaj yeem pab lub cev tiv thaiv kab mob hauv lub cev tua cov kabmob, thiab yuav cuam tshuam lub peev xwm ntawm cov qog ua kom loj hlob thiab kis tau. Kev muab tshuaj abexinostat thiab pembrolizumab tuaj yeem ua haujlwm zoo dua rau kev kho cov neeg mob qog ua pob.
Chaw: UCSF Medical Center-Mount Xi-oos, San Francisco, California
Qhov ncauj TrkA Tus Neeg Kho Mob VMD-928 rau Kev Kho Tus Mob Loj Dua Cov Qog Pob Qij Loj lossis Lymphoma
Qhov no yog ntau tus sau, qhib-daim ntawv lo, Ntu 1 kawm ntawm qhov ncauj siv VMD-928 hauv cov neeg laus kawm nrog cov qog ua haujlwm lossis cov qog ntshav uas tau nce lossis tsis muaj kev cuam tshuam rau cov kev kho mob thiab uas tsis muaj qauv lossis muaj cov kev kho kom zoo nkauj.
Qhov chaw: Nroog ntawm Kev Cia Siab Kev Kuaj Mob Cancer Center, Duarte, California
Kev Tshawb Fawb Txog Kev Tshawb Xyuas Txog Kev Tshawb Xyuas Kev Nyab Xeeb thiab Kev Ntsuam Xyuas ntawm Avelumab (MSB0010718C) hauv Thymoma thiab Thymic Carcinoma Tom qab Kev Tshawb Nrhiav ntawm Platinum-based Chemotherapy
Keeb Kwm Tom Qab: Thymoma thiab thymic carcinoma yog cov qog nqaij hlav uas tshwm sim nyob rau hauv lub thymus caj pas. Platinum-based chemotherapy yog kev kho mob qauv rau lawv. Tab sis tsis yooj yim dua, tus kab mob rov qab thiab tib neeg xav tau kev kho mob ntau dua ntxiv tiv thaiv tus kabmob kheesxaws zuj zus. Cov tshuaj Avelumab tuaj yeem pab kev tiv thaiv kab mob ua rau mob qog noj ntshav. Lub Hom Phiaj: Txhawm rau tshuaj ntsuam yog tias avelumab muaj kev nyab xeeb thiab muaj kev tiv thaiv zoo, thiab muaj kev kho mob thim rov qab los yog kho thymoma thiab thymic carcinoma. Kev Tsim Nyog: Cov tib neeg hnub nyoog 18 xyoo thiab laus dua nrog thymoma lossis thymic carcinoma uas tau rov qab los yog ua tiav tom qab platinum-muaj tshuaj kho mob Tsim: Cov neeg koom yuav raug kuaj nrog: - Ntshav, zis, thiab kuaj plawv - Tshuaj Ntsuam Xyuas: Lawv dag hauv lub tshuab uas siv duab lub cev. - Kev kuaj mob lub cev - Keeb kwm kev mob - Kev kuaj me: ib rab koob tshem tawm ntawm cov qog tawm. Cov qauv tuaj yeem yog los ntawm cov txheej txheem yav dhau los, txawm hais tias nws yog ntshaw kom yauv mus kuaj dua ib qho tshiab. Cov neeg koom yuav muaj kev kho mob rau 2-lub hlis mus los. Lawv yuav ua mus ntxiv kom txog thaum cov kev mob tshwm sim tsis tuaj yeem thev lossis lawv cov kab mob zuj zus. Qhov mus ntsib ntawm lub sij hawm tom qab no yuav tsum ua raws txoj cai. Cov neeg mob uas tau txais kev kho mob lossis muaj kev ruaj khov nyob tom qab kev kho mob tsawg kawg 12 lub hlis yuav tau txais kev kho kom zoo mus ntxiv rau kev kho mob. - Txhua 2 lub lis piam: Cov neeg tuaj koom yuav tau txais avelumab los ntawm kev nqus ntshav hauv txoj leeg ntshav (IV). Lawv yuav tau txais diphenhydramine (benadryl) thiab acetaminophen (tylenol) los ntawm qhov ncauj lossis IV ua ntej tau txais avelumab kom txo qis kev pheej hmoo ntawm kev tawm tsam avelumab. Lawv yuav muaj ntshav, zis, thiab kuaj plawv tsis tseg. - Cov voj voog 4 thiab 7, tom qab ntawd txhua 6 lub lis piam: Kev soj ntsuam yuav ua kom mus nrhiav kev ua kom lub ntsws lossis loj dua ntawm cov qog. - Phaum 4: Cov neeg koom yuav muab ib lub sijhawm rau kev rho tawm me me. - 2-4 lub lis piam tom qab nres kev kho mob: Ntshav, zis, thiab kuaj lub plawv. Cov neeg koom yuav raug kuaj mob. - 10 lub lis piam tom qab txiav kev kho mob: Ntshav, zis, thiab kuaj lub plawv. - Txog 6 lub hlis tom qab tsum tsis kho kev kho mob, tom qab ntawd txhua 3 lub hlis: Cov neeg tuaj koom yuav muaj scans andcan tso cai kuaj cov keeb ntawm lawv cov ntshav thiab cov nqaij mos.
Qhov Chaw: Cov Tsev Kawm Ntawv Hauv Tebchaws ntawm Chaw Kuaj Mob Noj Qab Haus Huv, Bethesda, Maryland
Pab saib xyuas nws pib-rov ua dua tshiab