Txog-mob cancer / kho mob / kuaj mob-sim / mob pob qij ntshav-mob cancer
Cov Chaw Kho Mob Nkag Mus Kho Tus Kab Mob Qog Yooj Yim
Kev Hais Plaub 1-4 ntawm 4
Nivolumab thiab Ipilimumab hauv Kev Kho Mob Rau Cov Neeg Mob Nrog Cov Qog Tsis Menyuam
Kev sim qib II no tshawb nivolumab thiab ipilimumab hauv kev kho cov neeg mob qog ua hlav. Kev txhaj tshuaj tiv thaiv kab mob nrog monoclonal tiv thaiv kab mob, xws li nivolumab thiab ipilimumab, tuaj yeem pab lub cev tiv thaiv kab mob hauv lub cev tua cov kab mob cancer, thiab yuav cuam tshuam lub peev xwm ntawm cov qog ntshav kom loj hlob thiab kis tau. Qhov kev sim no sau npe cov neeg tuaj koom rau hauv cov pawg neeg hauv qab no raws li kev mob: 1. Lub qog ua mob rau cov leeg mob hauv lub qhov ntswg, hlab ntshav ntswg, mob hlab pas: A) Cov npluag qog cell carcinoma nrog cov kab mob hauv lub qhov ntswg txhaws, pob txha ntswg, thiab qhov ntswg thiab mob hauv lub plab (tsis suav nrog laryngeal, nasopharyngeal cancer [NPC] , thiab squamous cell carcinoma ntawm lub taub hau thiab caj dab [SCCHN]) B) Adenocarcinoma thiab hloov pauv ntawm qhov ntswg ntawm lub qhov ntswg, mob siab, thiab nasopharynx (kaw rau accrual 07/27/2018) 2. Lub qog ua haujlwm ntawm cov qog ua kua qaub ntshav (kaw rau accrual 03 / 20/2018) 3. Salivary gland hom qog ntawm lub taub hau thiab caj dab, daim di ncauj, txoj hlab nqos mov, lub plab, lub plab thiab lub ntsws, lub mis thiab lwm qhov chaw (kaw rau accrual) 4. Tsis ua rau mob nqaij hlav ntawm txoj hnyuv plab hnyuv (GI) kev cuam tshuam 5. Adenocarcinoma nrog cov hnyuv me (kaw rau accrual 05/10/2018) 6. Cem muaj cov kab mob cell carcinoma nrog cov kab mob sib txawv ntawm GI (plab hnyuv plab hnyuv, lub plab hnyuv, lub qhov quav, lub ntsws) (kaw rau accrual 10/17/2018) 7. Fibromixoma thiab qis qib mucinous adenocarcinoma (pseudomixoma peritonei) ntawm cov hnyuv tws thiab zes qe menyuam (kaw rau accrual 03/20/2018) 8. Cov mob qog nqaij hlav raum tsis txaus nrog rau lub cev ua pob ntawm leeg, mob ua paug ntawm cystadenocarcinoma lossis mob cystadenocarcinoma. Pancreatic adenocarcinoma tsis tau txais txiaj ntsig 9. Intrahepatic cholangiocarcinoma (kaw rau accrual 03/20/2018) 10. Cov kab mob cholangiocarcinoma tshwj xeeb thiab bile leeg mob qog (kaw rau kom ze ntawm 03/20/2018) 11. Sarcomatoid carcinoma ntawm mob ntsws 12. Bronchoalveolar carcinoma mob ntsws. Qhov xwm txheej no tam sim no tseem hu ua adenocarcinoma hauv situ, tsis tshua muaj qhov tsis zoo adenocarcinoma, mob qog nqaij hlav adenocarcinoma, lossis qog ua paug adenocarcinoma 13. Cov qog tsis muaj kabmob: A) Germ cell hlav ntawm zes qe menyuam B) Mullerian sib xyaw cov qog thiab adenosarcoma to accrual 03/30/2018) 14. Lub qog ua pob: A) Choriocarcinoma (kaw rau accrual) 15. Mob qog nqaij hlav hauv hlwb hloov dua li ntawm lub raum, lub plab, txoj hlab zis, los yog lub zais zis (kaw mus rau qhov muaj mob) 16. Lub qog ntshav ntawm lub cov noob qog thiab cov hlav ua qe: A) Seminoma thiab qog deev leeg mob cancer B) Cov pob qij txha tsis-seminomatous C) Teratoma nrog muaj qhov ua tau zoo (kaw rau accrual) 17.
Qhov chaw: 895 qhov chaw
Kev soj ntsuam kom nquag, Bleomycin, Carboplatin, Etoposide, lossis Cisplatin hauv kev kho mob rau cov menyuam yaus thiab cov neeg laus nrog Mob Qog Pob Tawb Qib Cov theem III no tshawb nrhiav seb kev soj ntsuam zoo li cas, bleomycin, carboplatin, etoposide, lossis cisplatin ua haujlwm hauv kev kho mob rau menyuam yaus thiab cov neeg mob qog nqaij hlav Cov. Kev soj ntsuam nquag yuav pab cov kws kho mob saib xyuas cov ncauj lus uas muaj cov qog ua qog qis qis tom qab lawv cov qog tawm. Cov tshuaj siv hauv kev siv tshuaj kho mob, xws li bleomycin, carboplatin, etoposide, thiab cisplatin ua haujlwm rau ntau txoj hauv kev los tiv thaiv kev loj hlob ntawm cov qog hlwb, los ntawm tua cov hlwb, los ntawm kev txwv kom tsis txhob faib tawm, los yog txwv tsis pub kis. Qhov chaw: 460 qhov chaw
Inotuzumab Ozogamicin thiab Kev Kho Mob Tom Qab Kev Kho Mob hauv Kev Kho Mob rau Cov Neeg Mob Hlob B-TXHUA, Kev sib xyaw ua ke Phenotype Acute Leukemia, thiab B-LLy
Kev sim qib III no seb puas yog inotuzumab ozogamicin ntxiv rau kev kho mob tom qab lub cev rau cov neeg mob uas muaj Kev Nyuaj Siab B-cell Acute Lymphoblastic Leukemia (B-TXHUA) txhim kho cov txiaj ntsig tau. Qhov kev sim no tseem kawm txog qhov tshwm sim ntawm cov neeg mob uas muaj phenotype sib xyaw ua kom tsis muaj mob (MPAL), thiab B-lymphoblastic lymphoma (B-LLy) thaum kho nrog TXHUA txoj kev kho mob tsis muaj inotuzumab ozogamicin. Inotuzumab ozogamicin yog cov tshuaj monoclonal antibody, hu ua inotuzumab, txuas nrog ib hom kev kho mob tshuaj lom hu ua calicheamicin. Inotuzumab txuas rau cov kabmob kheesxaws hauv txoj kev ua kom zoo thiab muab cov calicheamicin los tua lawv. Lwm yam tshuaj uas siv hauv kev siv tshuaj kho mob, xws li cyclophosphamide, cytarabine, dexamethasone, doxorubicin, daunorubicin, methotrexate, leucovorin, mercaptopurine, prednisone, thioguanine, vincristine, thiab pegaspargase ua haujlwm nyob rau ntau txoj hauv kev los tiv thaiv kev loj hlob ntawm cov qog nqaij hlav cancer, los ntawm tua cov qog hlwb, los ntawm kev txwv lawv kom faib, lossis los tiv thaiv lawv los ntawm kev sib kis. Qhov kev sim no tseem yuav soj ntsuam cov txiaj ntsig ntawm cov neeg mob uas muaj ntau qhov sib xyaw ua ke ntawm cov neeg mob ntshav (MPAL) thiab tshaj tawm B lymphoblastic lymphoma (B-LLy) thaum kho nrog kev pheej hmoo TXHUA kev kho mob. Lub hom phiaj tag nrho ntawm qhov kev kawm no yog nkag siab yog tias ntxiv inotuzumab ozogamicin rau tus txheej txheem ntawm kev saib xyuas kev kho mob ua kom muaj txiaj ntsig zoo lossis ua kom muaj txiaj ntsig zoo ntawm Qhov Muaj Peev Xwm Loj B-cell Mob Mob Ntshav Qab Zib Lymphoblastic (HR B-TAG). Thawj ntu ntawm txoj kev tshawb no suav nrog thawj ob ntu kev kho: Induction thiab Consolidation. Ntu no yuav sau cov ntaub ntawv hais txog kev mob qog ntshav, nrog rau cov tshwm sim ntawm kev kho mob thaum xub thawj, txhawm rau txheeb xyuas cov neeg mob ua cov pab pawg tom qab kho kom zoo. Ntawm ntu ob ntawm qhov kev tshawb fawb no, cov neeg mob yuav tau txais cov seem ntawm cov tshuaj khomob mus ib ntus (kho ib ntus I, ncua kev qhia ntxiv, kev saib xyuas ib ntus II, txij nkawm), nrog qee tus neeg mob randomized kom tau txais inotuzumab. Lwm lub hom phiaj ntawm txoj kev tshawb fawb no suav nrog kev tshawb xyuas seb puas kho ob tus txiv neej thiab poj niam tib lub sijhawm siv tshuaj kho mob ua kom tshwm sim rau cov txiv neej uas yav tas los kho dua ib xyoos ntxiv piv rau cov menyuam ntxhais, nrog rau kev soj ntsuam txoj hauv kev zoo tshaj plaws los pab cov neeg mob Siv tshuaj tua hluav taws. Thaum kawg, qhov kev kawm no yuav yog thawj zaug los soj ntsuam qhov tshwm sim ntawm cov kev kawm uas tau tshaj tawm B-cell Lymphoblastic Leukemia (B LLy) lossis Mixed Phenotype Acute Leukemia (MPAL) thaum kho nrog B-TXHUA kev kho mob. cov neeg mob yuav tau txais cov kev kho mob seem uas tseem tshuav (kev saib xyuas ib ntus I, kev ncua sijhawm ntev, kev saib xyuas ib ntus II, txij nkawm), nrog qee tus neeg mob randomized kom tau txais inotuzumab. Lwm lub hom phiaj ntawm txoj kev tshawb fawb no suav nrog kev tshawb xyuas seb puas kho ob tus txiv neej thiab poj niam tib lub sijhawm siv tshuaj kho mob ua kom tshwm sim rau cov txiv neej uas yav tas los kho dua ib xyoos ntxiv piv rau cov menyuam ntxhais, nrog rau kev soj ntsuam txoj hauv kev zoo tshaj plaws los pab cov neeg mob Siv tshuaj tua hluav taws. Thaum kawg, qhov kev kawm no yuav yog thawj zaug los soj ntsuam qhov tshwm sim ntawm cov kev kawm uas tau tshaj tawm B-cell Lymphoblastic Leukemia (B LLy) lossis Mixed Phenotype Acute Leukemia (MPAL) thaum kho nrog B-TXHUA kev kho mob. cov neeg mob yuav tau txais cov kev kho mob seem uas tseem tshuav (kev saib xyuas ib ntus I, kev ncua sijhawm ntev, kev saib xyuas ib ntus II, txij nkawm), nrog qee tus neeg mob randomized kom tau txais inotuzumab. Lwm lub hom phiaj ntawm txoj kev tshawb fawb no suav nrog kev tshawb xyuas seb puas kho ob tus txiv neej thiab poj niam tib lub sijhawm siv tshuaj kho mob ua kom tshwm sim rau cov txiv neej uas yav tas los kho dua ib xyoos ntxiv piv rau cov menyuam ntxhais, nrog rau kev soj ntsuam txoj hauv kev zoo tshaj plaws los pab cov neeg mob Siv tshuaj tua hluav taws. Thaum kawg, qhov kev kawm no yuav yog thawj zaug los soj ntsuam qhov tshwm sim ntawm cov kev kawm uas tau tshaj tawm B-cell Lymphoblastic Leukemia (B LLy) lossis Mixed Phenotype Acute Leukemia (MPAL) thaum kho nrog B-TXHUA kev kho mob. Lwm lub hom phiaj ntawm txoj kev tshawb fawb no suav nrog kev tshawb xyuas seb puas kho ob tus txiv neej thiab poj niam tib lub sijhawm siv tshuaj kho mob ua kom tshwm sim rau cov txiv neej uas yav tas los kho dua ib xyoos ntxiv piv rau cov menyuam ntxhais, nrog rau kev soj ntsuam txoj hauv kev zoo tshaj plaws los pab cov neeg mob Siv tshuaj tua hluav taws. Thaum kawg, qhov kev kawm no yuav yog thawj zaug los soj ntsuam qhov tshwm sim ntawm cov kev kawm uas tau tshaj tawm B-cell Lymphoblastic Leukemia (B LLy) lossis Mixed Phenotype Acute Leukemia (MPAL) thaum kho nrog B-TXHUA kev kho mob. Lwm lub hom phiaj ntawm txoj kev tshawb fawb no suav nrog kev tshawb xyuas seb puas kho ob tus txiv neej thiab poj niam tib lub sijhawm siv tshuaj kho mob ua kom tshwm sim rau cov txiv neej uas yav tas los kho dua ib xyoos ntxiv piv rau cov menyuam ntxhais, nrog rau kev soj ntsuam txoj hauv kev zoo tshaj plaws los pab cov neeg mob Siv tshuaj tua hluav taws. Thaum kawg, qhov kev kawm no yuav yog thawj zaug los soj ntsuam qhov tshwm sim ntawm cov kev kawm uas tau tshaj tawm B-cell Lymphoblastic Leukemia (B LLy) lossis Mixed Phenotype Acute Leukemia (MPAL) thaum kho nrog B-TXHUA kev kho mob.
Qhov chaw: 189 qhov chaw
Kev nrawm lossis qauv BEP Kev Siv Tshuaj Kho Mob hauv Kev Kho Mob Cov Neeg Mob Nruab Nrab lossis Qis Tsis Zoo Kev Raug Ploj Kab Ntsig
Qhov kev sim rau qib III no kawm txog seb lub sijhawm teev ntshav sai sai npaum li cas ntawm bleomycin sulfate, etoposide phosphate, thiab cisplatin (BEP) kws kho mob ua haujlwm piv rau cov sijhawm ua haujlwm ntawm BEP kev kho tshuaj hauv kev kho cov neeg mob nruab nrab lossis qis qis cov kabmob qog uas tau kis mus rau lwm yam cov chaw hauv lub cev (metastatic). Cov tshuaj siv hauv kev siv tshuaj kho mob, xws li bleomycin sulfate, etoposide phosphate, thiab cisplatin ua haujlwm rau ntau txoj hauv kev los tiv thaiv kev loj hlob ntawm cov qog hlwb, los ntawm kev tua cov qog, los ntawm kev txwv kom tsis txhob faib tawm, los yog txwv tsis pub kis. Kev muab tshuaj BEP ua rau tshuaj lom neeg mob sai dua, lossis "ua kom ceev nrawm dua" tuaj yeem ua haujlwm zoo dua nrog cov kev mob tshwm sim tsawg dua hauv kev kho mob rau cov neeg mob cov neeg mob qog nruab nrab lossis tsis muaj kabmob txaus rau cov kabmob qog nqaij hlav ua piv rau cov qauv sijhawm.
Qhov chaw: 139 qhov chaw
Pab saib xyuas nws pib-rov ua dua tshiab